LU500897B1

LU500897B1 - Traditional Chinese Medicine Compound Composition for Treating Hyperbolic Syndrome, and its Preparation Method and Application

Info

Publication number: LU500897B1
Application number: LU500897A
Authority: LU
Inventors: Yanchun Ma
Original assignee: Univ Heilongjiang Chinese Medicine
Priority date: 2021-11-24
Filing date: 2021-11-24
Publication date: 2022-05-24

Abstract

The invention discloses a traditional Chinese medicine compound composition for treating hyperbolic syndrome, which is prepared from Codonopsis pilosula, Atractylodes macrocephala Koidz., Folium Perillae, Pinellia ternata, Perilla frutescens, Citri Reticulatae Viride Pericarpium, Lindera aggregata, raw rhubarb, wine-processed rhubarb, peony bark, stir-baked Prunus persica, stir-stir-fried wax gourd kernel, Fructus Aurantii Immaturus, Fructus Aurantii, Curcuma phaeocaulis Valeton, Patrinia herb, Taraxacum mongolicum, mirabilite, Corydalis yanhusuo, Fructus Toosendan, Magnolia officinalis, fried Semen Trichosanthis, Massa Medicata Fermentata, malt, Radix Curcumae, Cimicifuga rhizome, Cinnamomum cassia Presl, Radix Paeoniae Alba, Korean pine bark, Angelica sinensis, ethyl acetate extracts of Rehmannia glutinosa and jujube, n-hexane extracts of cinnamon, pepper, Zanthoxylum bungeanum and fennel, glycerol extracts of peppermint and Smilax glabra. The traditional Chinese medicine formula of the invention is scientific and reasonable, has the effects of soothing the liver and regulating qi, broadening the intestines and promoting qi, nourishing blood and moistening the intestines, and strengthening the spleen.

Description

DESCRIPTION Traditional Chinese Medicine Compound Composition for Treating Hyperbolic Syndrome, and its Preparation Method and Application

TECHNICAL FIELD

[0001] The present invention relates to a traditional Chinese medicine compound composition, in particular to a traditional Chinese medicine compound composition for treating hyperbolic syndrome, its preparation method and application.

BACKGROUND

[0002] In recent years, some people who have been working at their desks for a long time, such as writers, university teachers, researchers in research institutes, self-employed bosses, journalists or editors, are prone to not only cervical spondylosis, but also an occupational disease called "hyperbolic syndrome". In human abdominal cavity, because the curved parts at the junction of ascending colon, descending colon and transverse colon are respectively below liver and spleen, they are called liver curvature and spleen curvature. When eating fast, feeling depressed, indigestion, or chronic inflammation of abdominal viscera, especially when working at your desk for too long, it is easy to cause intestinal dysfunction and stagnation of qi volume in liver and spleen. It leads to abdominal distension, discomfort, faint pain and other symptoms. Clinically, this disease is called liver curvature syndrome and spleen curvature syndrome, also known as "hyperbolic syndrome".

[0003] Diagnostic points of hyperbolic syndrome: (1) splenic flatulence is mainly discomfort, pain and constipation in the lower left chest or upper left abdomen; (2) liver curvature flatulence is mainly pain, discomfort, heartburn, belching, acid reflux and nausea in the right upper abdomen; (3) severe cases are mainly severe distension or severe pain, the degree of which is proportional to flatulence; after defecation or cleaning enema, flatulence disappears, and the pain is also relieved or disappeared; (4) abdominal pain can occur slowly or suddenly, with different duration. The short one can be relieved in a few minutes (commonly known as "Chest Pain" ), and the long one can have pain in both sides for several hours or a long time, and the pain has nothing to do with diet; (5)

physical examination shows that the upper abdomen 1s full, percussion showed drum sound, and there are no other positive signs; (6) abdominal X-ray fluoroscopy shows B- ultrasound, CT and duodenoscopy, and (7) pathological examination shows that the intestinal membrane is thick or the intestinal wall is in contracture state, which is about

11.5 cm thick; under the endoscope, the colonic mucosa shows chronic inflammatory changes, and some of the submucosa shows lymphocytes infiltrating serosal fibrous tissue hyperplasia and inflammatory cells infiltrating into seromuscular layer.

[0004] The most effective treatment for liver (spleen) syndrome is surgical treatment. At present, the most effective surgical treatment for liver (spleen) syndrome is as follows:

[0005] (1) simple operation of relaxing the splenic flexure of colon or side-to-side anastomosis of the splenic flexure of colon: because the ascending branch and descending branch of splenic flexure are seriously adhered to the lower pole of the spleen and the lower edge of the tail of pancreas, especially the elderly and infirm, they can't stand the larger operation, so the operation is incomplete, the residual lesions still remain after operation, the transverse colon is prolonged and dilated, the accumulated feces can't be discharged completely, and even systemic poisoning symptoms appear;

[0006] (2) more thorough proximal subtotal colectomy: proximal subtotal colectomy is feasible if splenomegaly syndrome combined with ascending colon, intestine and liver curvature and transverse colon dilatation and thickening; if the syndrome of liver (spleen) is complicated with prolonged dilatation and thickening of the transverse colon of the ascending colon and the middle and upper segment of the sigmoid colon of the descending colon, subtotal colectomy is feasible; if the syndrome of liver (spleen) is complicated with liver curvature of ascending colon and colon, redundant expansion and thickening of transverse colon, redundant expansion of descending colon and sigmoid colon, total colectomy is feasible.

[0007] However, postoperative complications are common: pelvic infection, colon torsion, functional intestinal obstruction, ischemic colitis, increased defecation frequency, fecal incontinence, constipation and abdominal distension, long-term low fever and low immunity. Stress ulcerative colitis, heart failure, renal failure, respiratory failure, urinary retention, etc.

[0008] In view of the above disadvantages of surgical treatment, it is necessary to design and develop a Chinese medicine compound composition with scientific and reasonable formula and effective treatment of liver (spleen) syndrome on the basis of the existing technology and according to the syndrome differentiation and treatment of traditional Chinese medicine compound composition.

SUMMARY

[0009] Objective of the invention: the objective of the invention is to overcome the serious complications caused by the existing surgical treatment methods, adopt the theory of syndrome differentiation and treatment, and through a large number of experiments, provide a medicine with scientific and reasonable proportion, low cost, convenient administration and good safety, which has the effects of soothing liver and regulating qi, relaxing intestine and promoting qi circulation, nourishing blood and moistening intestine, strengthening spleen and eliminating turbidity, eliminating phlegm and resolving hard mass, benefiting gallbladder and eliminating stagnation, and can effectively treat liver (spleen and spleen). Another objective of that present invention is to provide the preparation method and application of the traditional Chinese medicine compound composition.

[0010] Technical scheme: in order to achieve the above objectives, the technical scheme adopted by the present invention is as follows:

[0011] A traditional Chinese medicine compound composition for treating hyperbolic syndrome is prepared from the following raw materials in parts by weight:

[0012] 10-30 parts of Codonopsis pilosula extract, 10-30 parts of Atractylodes macrocephala Koidz. extract, 10-20 parts of Folium Perillae and 10-20 parts of Pinellia ternata, 30-90 of parts Perilla frutescens, 20-40 parts of Citri Reticulatae Viride Pericarpium, 15-30 parts of Lindera aggregata, 5-10 parts of raw rhubarb, 10-15 parts of wine-processed rhubarb, 10-25 parts of peony bark, 10-15 parts of stir-baked Prunus persica, 10-25 parts of stir-fried wax gourd kernel, 10-25 parts of Fructus Aurantii Immaturus, 10-15 parts of Fructus Aurantii, 5-10 parts of Curcuma phaeocaulis Valeton, 10-25 parts of Patrinia herb, 10-25 parts of Taraxacum mongolicum, 1-10 parts of mirabilite, 1-25 parts of Corydalis yanhusuo, 1-5 parts of Fructus Toosendan, 1-15 parts of Magnolia officinalis, 10-35 parts of fried Semen Trichosanthis, 10-35 parts of Massa

Medicata Fermentata, 10-35 parts of malt, 5-35 parts of Radix Curcumae, 15-45 parts of Cimicifuga rhizome, 5-35 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 2-8 parts of Korean pine bark ethyl acetate extract, 2-8 parts of Angelica sinensis ethyl acetate extract, 2-8 parts of Rehmannia glutinosa ethyl acetate extract, 2-8 parts of jujube ethyl acetate extract, 2-8 parts of cinnamon n-hexane extract, 1-8 parts of pepper n-hexane extract. 1-8 parts of Zanthoxylum bungeanum n-hexane extract, 1-5 parts of fennel n-hexane extract, 1-5 parts of peppermint glycerol extract and 1-10 parts of Smilax glabra glycerol extract.

[0013] As a preferred scheme, the above-mentioned traditional Chinese medicine compound composition for treating hyperbolic syndrome is prepared from the following raw materials in parts by weight:

[0014] 10 parts of Codonopsis pilosula extract, 10 parts of Atractylodes macrocephala Koidz. extract, 10 parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 20 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 5 parts of raw rhubarb, 10 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir-baked Prunus persica, 15 parts of stir-stir-fried wax gourd kernel, 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 10 parts of Patrinia herb, 10 parts of Taraxacum mongolicum, 2 parts of mirabilite, 5 parts of Corydalis yanhusuo, 2 parts of Fructus Toosendan, 5 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 5 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 2 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 2 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n-hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n-hexane extract, 1 part of peppermint glycerol extract and 1 part of Smilax glabra glycerol extract.

[0015] As the preferred scheme, the above-mentioned traditional Chinese medicine compound composition for treating hyperbolic syndrome, the Codonopsis pilosula extract and the Atractylodes macrocephala Koidz. extract are prepared by the following methods: taking Codonopsis pilosula and Atractylodes macrocephala Koidz., respectively, adding

8-16 times of ethanol with a volume concentration of 10%, refluxing and extracting for 1- 3 times, each time for 30-120 minutes, combining the extracts, and concentrating to obtain extract.

[0016] As the preferred scheme, the above-mentioned traditional Chinese medicine compound composition for treating hyperbolic syndrome, the Korean pine bark ethyl acetate extract, the Angelica sinensis ethyl acetate extract, the Rehmannia glutinosa ethyl acetate extract and the jujube ethyl acetate extract are prepared by the following methods: respectively taking Korean pine bark, Angelica sinensis, Rehmannia glutinosa and jujube, crushing them with a 40 mesh sieve, and extracting them with 60% ethanol for 3 times, each time for 30 to 60 minutes; recovering the ethanol, then extracting them with n- hexane, dichloromethane and ethyl acetate, taking the ethyl acetate extract, and distilling them under reduced pressure to obtain the ethyl acetate extract.

[0017] As a preferred scheme, the above-mentioned traditional Chinese medicine compound composition for treating hyperbolic syndrome, the cinnamon n-hexane extract, pepper n-hexane extract, Zanthoxylum bungeanum n-hexane extract and fennel n-hexane extract are prepared by the following methods: crushing cinnamon, pepper, Zanthoxylum bungeanum and fennel respectively, sieving with a 40 mesh sieve, then refluxing and extracting with n-hexane for 1-3 times, each time for 30-60 minutes, recovering n- hexane, and obtaining the n-hexane extracts of cinnamon, pepper, Zanthoxylum bungeanum and fennel respectively.

[0018] As a preferred scheme, the above-mentioned traditional Chinese medicine compound composition for treating hyperbolic syndrome, the peppermint glycerol extract and Smilax glabra glycerol extract are prepared by the following methods: respectively taking peppermint and Smilax glabra, crushing with a 40 mesh sieve, and then ultrasonically extracting with 50% glycerol aqueous solution.

[0019] The preparation method of the traditional Chinese medicine compound composition for treating hyperbolic syndrome of the invention comprises the following steps:

[0020] (1) taking Folium Perillae, Pinellia ternata, Perilla frutescens, Citri Reticulatae Viride Pericarpium, Lindera aggregata, raw rhubarb, wine-processed rhubarb, peony bark, stir-baked Prunus persica, stir-stir-fried wax gourd kernel, Fructus Aurantii

Immaturus, Fructus Aurantii, Patrinia herb, Taraxacum mongolicum, mirabilite, Corydalis yanhusuo, Fructus Toosendan, Magnolia officinalis, fried Semen Trichosanthis, Massa Medicata Fermentata, malt, Radix Curcumae, Cimicifuga rhizome, Cinnamomum cassia Presl, and Radix Paeoniae Alba, pulverizing, sieving with 40 mesh sieve, and then adding 20%-40% volume ethanol for ultrasonic extraction for 2-3 times, 2-3 hours each time; after solid-liquid centrifugation, obtaining the supernatant, concentrating and obtaining the extract, which is used for standby;

[0021] (2) taking Korean pine bark, Angelica sinensis, Rehmannia glutinosa and jujube by weight, crushing them with 40 mesh sieve, first extracting them with 60% ethanol for 2-3 times, each time for 30-60 minutes, recovering the ethanol, then extracting them with n-hexane, dichloromethane and ethyl acetate in turn, taking the ethyl acetate extract, distilling under reduced pressure to obtain ethyl acetate extract, mixing with soluble edible starch and freeze-drying to obtain the extract;

[0022] (3) according to parts by weight, taking cinnamon, pepper, Zanthoxylum bungeanum and fennel, crushing them with a 40 mesh sieve, then reflux-extracting them with n-hexane for 1-3 times, each time for 30-60 minutes, and recovering the n-hexane to obtain n-hexane extracts of cinnamon, pepper, Zanthoxylum bungeanum and fennel,

[0023] (4) according to parts by weight, taking peppermint and Smilax glabra, crushing them with a 40 mesh sieve, and then ultrasonically extracting them with 50% glycerin aqueous solution of food grade to obtain glycerol extracts of peppermint and Smilax glabra,

[0024] (5) according to parts by weight, adding Codonopsis pilosula and Atractylodes macrocephala Koidz. with 10% ethanol for reflux extraction for 2-3 times, each time for 30-60 minutes, and concentrating the extract to obtain the extract;

[0025] (6) preparing the extract obtained in step (1), the freeze-dried powder obtained in step (2), the glycerol extracts of peppermint and Smilax glabra obtained in step (4), the extracts of Codonopsis pilosula and Atractylodes macrocephala Koidz. obtained in step (5) and pharmaceutically acceptable carriers into traditional Chinese medicine preparations. The n-hexane extracts of cinnamon, pepper, Zanthoxylum bungeanum and fennel obtained in step (3) are applied to navel.

[0026] The preparation method of traditional Chinese medicine compound composition for treating hyperbolic syndrome of the present invention, the traditional Chinese medicine preparation is granule, tablet, capsule, oral liquid, dripping pill or soft capsule.

[0027] The application of the traditional Chinese medicine compound composition for treating hyperbolic syndrome provided by the invention in preparing medicines for treating hyperbolic syndrome.

[0028] The present invention has been optimized through a large number of experiments to obtain the best formula, in which Atractylodes macrocephala Koidz. has the functions of invigorating spleen, benefiting stomach, eliminating dampness, harmonizing the middle warmer and preventing miscarriage, and is mainly used for treating spleen- stomach qi weakness, anorexia, listlessness, asthenia, diarrhea, phlegm retention, edema, jaundice, dampness arthralgia, dysuria, dizziness, spontaneous perspiration and fetal gas anxiety. Atractylodes macrocephala Koidz. has hypoglycemic, diuretic, antibacterial, antitumor and anticoagulant effects.

[0029] In the compound prescription, the effect of Codonopsis pilosula is to tonify middle energizer, invigorate spleen and benefit lung. It is mainly used for treating spleen and lung weakness, shortness of breath, palpitation, anorexia, loose stool, asthma, cough and internal heat to quench thirst.

[0030] In the compound prescription, Perilla frutescens has the effect of dispelling cold and relieving exterior syndrome, regulating qi, and relieving pain. It is used for cold, headache, cough and abdominal distension. Citri Reticulatae Viride Pericarpium soothes liver and breaks qi, disperses stagnation and eliminates phlegm. Citri Reticulatae Viride Pericarpium 1s used to treat chest and hypochondriac epigastric pain, hernia, food accumulation, breast swelling, breast nucleus and chronic malaria, @ Atlas of Meteria Medica: "Citri Reticulatae Viride Pericarpium is mainly used for qi stagnation, ingestion, breaking accumulation knot and dysphagia syndrome."

[0031] Lindera aggregata is used to regulate qi and relieve pain, warm kidney and dispel cold. It can be used for abdominal pain, dyspnea, bladder deficiency and cold, enuresis and frequent urination, hernia and dysmenorrhea.

[0032] Raw rhubarb is used to purge excess heat, break up stagnation and remove blood stasis. Indications: constipation due to excess heat, food stagnation, abdominal pain, acute appendicitis, acute infectious hepatitis, amenorrhea due to blood stasis, toothache, epistaxis and acute conjunctivitis; for external use, burn, scald, suppurative skin disease, carbuncle, swelling and sore.

[0033] Wine-processed rhubarb 1s good at clearing up the scorched blood and dividing heat toxin. It can be used for swollen eyes and swollen gums.

[0034] Peony bark is used to clear away heat and cool blood, promote blood circulation and remove blood stasis. It can be used for treating fever, macula, hematemesis and epistaxis, night fever abating at dawn, no sweat, bone steaming, amenorrhea, dysmenorrhea, carbuncle, swelling and sore, traumatic pain.

[0035] Stir-baked Prunus persica (peeled) are used to promote blood circulation and remove blood stasis, moisten intestines and relieve constipation. It can be used for amenorrhea, dysmenorrhea, lump, traumatic injury, intestinal dryness and constipation.

[0036] Stir-stir-stir-fried wax gourd kernel is selected, and its efficacy and indications are clearing lung, eliminating phlegm and discharging pus. It is suitable for cough due to lung heat, pulmonary carbuncle, intestinal carbuncle and other diseases.

[0037] Fructus Aurantii Immaturus is selected to break Qi and eliminate accumulation; remove phlegm and ruffian. The main treatment is accumulation stagnation and internal stop; fullness, swelling and pain; stool secret knot; severe diarrhea; breast knot; gastroptosis; uterine prolapse; anal prolapse.

[0038] Fructus Aurantii is used for treating fullness of chest septum; hypocostal swelling pain; indigestion; abdominal distension; severe diarrhea; anal prolapse; uterine prolapse.

[0039] In the compound, Curcuma phaeocaulis Valeton has the functions of promoting Qi, breaking blood, eliminating accumulation and relieving pain. It is used for swelling and swelling masses, blood stasis, amenorrhea, food accumulation, swelling and pain;

[0040] Patrinia herb has the effects of clearing away heat and toxic materials, eliminating carbuncle and discharging pus, promoting blood circulation and removing blood stasis. It can be used for intestinal carbuncle, lung carbuncle, abscess, swelling and toxin, chest and abdominal pain caused by excess heat and blood stasis, postpartum blood stasis and abdominal pain, etc.

[0041] Taraxacum mongolicum, effective in clearing away heat and toxic materials, reducing swelling and resolving hard mass, inducing diuresis and stranguria. It can be used for furuncle, breast carbuncle, scrofula, red eyes, sore throat, lung carbuncle, intestinal carbuncle, damp-heat jaundice, stranguria and astringent pain.

[0042] Mirabilite is salty, slightly bitter and cold in nature. Mirabilite belongs to the stomach and large intestine. Mirabilite has the functions of purgation, heat clearing and softening hardness. It can be used for treating constipation due to heat accumulation, abdominal distension and pain, lump accumulation, carbuncle swelling, red eyes, aphtha, erysipelas, etc.

[0043] Corydalis yanhusuo has the effects of promoting blood circulation, benefiting qi and relieving pain. It can be used for chest pain, abdominal pain, amenorrhea, dysmenorrhea, postpartum stasis, and swelling and pain.

[0044] Fructus Toosendan, effective in soothing liver, activating qi, relieving pain and expelling insects. It can be used for chest and hypochondriac pain, abdominal pain, colic, and abdominal pain caused by insect infestation.

[0045] Magnolia officinalis has the effect of eliminating dampness and phlegm, and relieving fullness of qi. It can be used for damp stagnation injury, abdominal distension, constipation, phlegm, vomiting and diarrhea, food stagnation and qi stagnation, abdominal distension, constipation, phlegm, asthma and cough.

[0046] Fried Semen Trichosanthis, Semen Trichosanthis fried: "tonifying asthenia, dry mouth, moistening heart and lungs, treating hematemesis, intestinal wind diarrhea, red and white dysentery, hand wrinkles".

[0047] Massa Medicata Fermentata has the effect of strengthening spleen and stomach; digestion and accumulation. Massa Medicata Fermentata mainly treats stagnation; indigestion; epigastric fullness; loss of appetite; vomiting and diarrhea.

[0048] Malt has the effect of digestion, harmonizing the middle warmer and lending down abnomally ascending qi. Malt is used to treat food accumulation, abdominal distension, loss of appetite, vomiting and diarrhea, and breast distention.

[0049] Radix Curcumae, effective in promoting qi circulation and removing blood stasis, clearing heart-fire, relieving depression, benefiting gallbladder and relieving jaundice. It is used for amenorrhea, dysmenorrhea, chest and abdominal pain, tingling, fever, dizziness, epilepsy, jaundice and red urine.

[0050] Cimicifuga rhizome has the effect of releasing rash, clearing away heat and toxic materials, and raising yang spirit. It is used for wind-heat headache, toothache, aphtha, sore throat, impenetrable measles, and rash caused by yang poison; anorectal prolapse and uterine prolapse.

[0051] Cinnamomum cassia Presl, effective in sweating, relieving muscles, warming meridians and dredging meridians. It is used for treating wind-cold exterior syndrome, soreness of shoulder and back limbs, chest obstruction and phlegm retention, amenorrhea and abdominal pain.

[0052] Radix Paeoniae Alba has functions of nourishing blood, softening liver, relieving pain, astringing yin and sweating. It is used for treating chest and abdomen flank pain, diarrhea and abdominal pain, spontaneous sweating and night sweats, fever due to yin deficiency, irregular menstruation, metrorrhagia and leukorrhagia.

[0053]Korean pine bark can prolong life, nourish blood and moisten intestines.

[0054] Angelica sinensis, effective in enriching blood and blood, regulating menstruation and relieving pain, moistening dryness and smoothing intestines. It is used for treating irregular menstruation, amenorrhea abdominal pain, lump and collapse, metrorrhagia; headache due to blood deficiency, dizziness, paralysis; intestinal dryness and difficulty in defecation, and severe dysentery; carbuncle, sore, theft, falling injury.

[0055] Rehmannia glutinosa is effective in nourishing yin and blood. It is used for treating yin deficiency and blood deficiency, weak waist and knees, fatigue and cough, bone steaming, spermatorrhea, metrorrhagia, irregular menstruation, thirst, polydipsia, deafness and blurred vision.

[0056] Jujube has the functions of invigorating spleen and stomach, benefiting qi, promoting fluid production, harmonizing ying and wei and relieving poison. It is used for treating stomach deficiency, poor appetite, weak spleen, loose stool, deficiency of qi, blood and body fluid, disharmony between ying and wei, palpitation. Cinnamon supplements Yuanyang, warms the spleen and stomach, removes accumulated cold and dredges blood vessels. It can be used for the treatment of debilitation of the life gate fire, slight cold pulse of limbs, debility of dead yang, abdominal pain and diarrhea, cold hernia running to dolphin, cold pain of waist and knees, amenorrhea, abdominal pain, vaginal gangrene, dribbling, excessive yang, upper heat and lower cold.

[0057] Pepper, effective in warming middle warmer, dispelling cold, purging qi and eliminating phlegm. It can be used for vomiting due to stomach cold, diarrhea due to abdominal pain, inappetence and excessive phlegm due to epilepsy.

[0058] Zanthoxylum bungeanum has the effects of warming middle temperature and relieving pain, killing insects and relieving itching. It can be used for abdominal cold pain, vomiting and diarrhea, abdominal pain caused by worm accumulation and ascariasis; external treatment of eczema and pruritus.

[0059] fennel has the effects of activating qi and relieving pain, invigorating stomach and dispelling cold. Indications: Cold pain in stomach, cold pain in lower abdomen, dysmenorrhea, colic, testicular hydrocele, schistosomiasis.

[0060] Peppermint has the effect of dispelling wind, dissipating heat, removing filth and detoxifying. It can be used for treating exogenous wind-heat, headache, red eyes, sore throat, food stagnation, flatulence, mouth sores, toothache, furuncle and addiction rash.

[0061] Smilax glabra has the effects of detoxification, dehumidification and joint benefit. It can be used for treating syphilis, stranguria, muscle and bone contracture, beriberi, furuncle, carbuncle, swelling and scrofula.

[0062] The combination of the above medicines has good effects of soothing liver and regulating qi, relaxing intestine and activating qi, nourishing blood and moistening intestine, strengthening spleen and eliminating turbidity, eliminating phlegm and resolving hard mass, promoting gallbladder and resolving stagnation, and can be used for the treatment of hyperbolic syndrome (liver curvature and spleen curvature).

[0063] The application method of the traditional Chinese medicine compound composition for treating hyperbolic syndrome (liver curvature and spleen curvature) of the present invention includes the following steps:

[0064] Different forms of drugs made from Folium Perillae, Pinellia ternata, Perilla frutescens, Citri Reticulatae Viride Pericarpium, Lindera aggregata, raw rhubarb, wine- processed rhubarb, peony bark, stir-baked Prunus persica, stir-stir-fried wax gourd kernel, Fructus Aurantii Immaturus, Fructus Aurantii, Patrinia herb, Taraxacum mongolicum, mirabilite, Corydalis yanhusuo, Fructus Toosendan, Magnolia officinalis, fried Semen Trichosanthis, Massa Medicata Fermentata, malt, Radix Curcumae, Cimicifuga rhizome, Cinnamomum cassia Presl, Radix Paeoniae Alba, Korean pine bark,

Angelica sinensis, Rehmannia glutinosa, jujube, Atractylodes macrocephala Koidz. and Codonopsis pilosula extracts according to the invention are taken orally together.

[0065] The cinnamon, pepper, Zanthoxylum bungeanum and fennel n-hexane extracts prepared by the invention are placed in the navel of a patient, covered with a navel patch, and the burning moxa stick is used for moxibustion above the navel patch to promote the absorption of drugs through the navel.

[0066] The 50% glycerin aqueous solution of peppermint and Smilax glabra prepared by the present invention can be enema without reservation according to different cold syndrome and heat syndrome manifestations of patients.

[0067] When the extracts of the raw materials of the traditional Chinese medicine compound composition provided by the invention are made into oral liquid, the extracts of the raw materials are dissolved in distilled water, filtered, edible surfactants and emulsifiers are added, the pH value is adjusted, and the oral liquid is made.

[0068] When the extract of the raw material of the traditional Chinese medicine compound composition provided by the invention is made into tablets, the raw material and lactose (which is not suitable for diabetic patients) or corn starch, if necessary, are added with magnesium stearate as lubricant, mixed evenly, granulated, and then tabletted to make tablets.

[0069] When the extract of the raw material of the traditional Chinese medicine compound composition provided by the invention is made into tablets, the raw material and lactose (which is not suitable for diabetic patients) or corn starch, if necessary, are added with magnesium stearate as lubricant, evenly mixed, granulated and then encapsulated into capsules.

[0070] When the extract of the raw material of the traditional Chinese medicine compound composition provided by the invention is made into tablets, the raw material and lactose (which is not suitable for diabetic patients) or corn starch, if necessary, are added with magnesium stearate as lubricant, mixed evenly, granulated and made into granules.

[0071] The traditional Chinese medicine compound composition provided by the invention has the efficacies of soothing liver and regulating qi, relaxing intestine and activating qi, nourishing blood and moistening intestine, strengthening spleen and eliminating turbidity, eliminating phlegm and resolving hard mass, promoting gallbladder function and resolving stagnation, and can be used for preparing drugs for treating liver (spleen) flexure syndrome.

[0072] Beneficial effects: Compared with the prior art, the traditional Chinese medicine compound composition provided by the invention has the following advantages:

[0073] According to the basic theory of traditional Chinese medicine based on syndrome differentiation and treatment, the prescription of traditional Chinese medicine provided by the invention is scientific and reasonable in proportion, and strict in medication. Experimental results show that the traditional Chinese medicine compound provided by the invention has good effects of dispersing stagnated liver qi, relaxing intestine circulation, nourishing blood and moistening intestine, invigorating spleen and eliminating turbidity, eliminating phlegm and resolving hard masses, and promoting gallbladder and resolving stagnation. It has a good therapeutic effect on liver curvature and spleen curvature syndrome, with high cure rate, low adverse reactions and good clinical medication safety.

[0074] The preparation method of the traditional Chinese medicine compound composition provided by the invention is reasonable in the whole process design, the best extraction process is screened out according to the physical and chemical properties of each medicine taste, and different extraction and separation methods are adopted for different raw materials, so that the extracted extract has the advantages of high content of active ingredients, stronger pharmacological activity, less impurities, low adverse reactions and the like, and can be conveniently prepared into various clinical preparations and is convenient to take.

DESCRIPTION OF THE INVENTION

[0075] The present invention will be further illustrated with specific examples. It should be understood that these examples are only used to illustrate the present invention and not to limit its scope. After reading the present invention, various equivalent modifications of the present invention by those skilled in the art will fall within the scope defined by the appended claims of this application.

[0076] Embodiment 1

[0077] 1. A traditional Chinese medicine compound composition for treating hyperbolic syndrome (liver curvature and spleen curvature) is prepared from the following medicines in parts by weight: 10 parts of Codonopsis pilosula extract, 10 parts of Atractylodes macrocephala Koidz. extract, 10 parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 20 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 5 parts of raw rhubarb, 10 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir-baked Prunus persica (peeled), 15 parts of stir-stir-fried wax gourd kernel, 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 10 parts of Patrinia herb, 10 parts of Taraxacum mongolicum, 2 parts of mirabilite, 5 parts of Corydalis yanhusuo, 2 parts of Fructus Toosendan, 5 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 5 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 2 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 2 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n- hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n- hexane extract, 1 part of peppermint glycerol extract and 1 part of Smilax glabra

[0078] 2. The preparation method of the traditional Chinese medicine compound composition for treating hyperbolic syndrome (liver curvature and spleen curvature) of the present invention comprises the following steps:

[0079] Firstly, the above-mentioned Codonopsis pilosula, Atractylodes macrocephala Koidz., Folium Perillae, Pinellia ternata, Perilla frutescens, Citri Reticulatae Viride Pericarpium, Lindera aggregata, raw rhubarb, wine-processed rhubarb, peony bark, stir- baked Prunus persica (peeled), stir-stir-fried wax gourd kernel, Fructus Aurantii Immaturus, Fructus Aurantii, Curcuma phaeocaulis Valeton, Patrinia herb, Taraxacum mongolicum, mirabilite, Corydalis yanhusuo, Fructus Toosendan, Magnolia officinalis, fried Semen Trichosanthis, Massa Medicata Fermentata, malt, Radix Curcumae, Cimicifuga rhizome, Cinnamomum cassia Presl, Radix Paeoniae Alba, Korean pine bark, Angelica sinensis, Rehmannia glutinosa, jujube are selected and cleaned respectively and dried in a drying oven with a drying temperature of 45 to 55°C.

[0080] Take Folium Perillae, Pinellia ternata, Perilla frutescens, Citri Reticulatae Viride Pericarpium, Lindera aggregata, raw rhubarb, wine-processed rhubarb, peony bark, stir- baked Prunus persica, stir-stir-fried wax gourd kernel, Fructus Aurantii Immaturus, Fructus Aurantii, Patrinia herb, Taraxacum mongolicum, mirabilite, Corydalis yanhusuo, Fructus Toosendan, Magnolia officinalis, fried Semen Trichosanthis, Massa Medicata Fermentata, malt, Radix Curcumae, Cimicifuga rhizome, Cinnamomum cassia Presi, Radix Paeoniae Alba according to the above weight parts, crush them and pass through 40 mesh sieve, then add 20%-40% ethanol for ultrasonic extraction for 3 times, 2 hours each time. After solid-liquid centrifugation, obtain the supernatant, concentrate and obtain the extract for later use.

[0081] According to the above parts by weight, Codonopsis pilosula and Atractylodes macrocephala Koidz. are added with 10% ethanol by volume for reflux extraction twice, each time for 60 minutes, and the extract is concentrated to prepare Codonopsis pilosula and Atractylodes macrocephala Koidz. with 10% ethanol for extraction and concentration into liquid medicine.

[0082] According to the above parts by weight, Korean pine bark, Rehmannia glutinosa, Angelica sinensis and jujube are crushed into powder by a crusher, sieved by a 40 mesh sieve, and the large pieces after sieving continue to be crushed; after crushing, 95% ethanol is used for ultrasonic extraction and concentration to obtain extract; after the extract is made into water suspension, petroleum ether, dichloromethane and ethyl acetate are used for extraction in turn; and the ethyl acetate extract is mixed with soluble starch, freeze-dried and then put into glass bottle and sealed at 4°C for storage.

[0083] According to the above parts by weight, the n-hexane extracts of cinnamon, pepper, Zanthoxylum bungeanum and fennel are prepared by crushing medicinal materials, directly extracting the powder obtained by sieving with 40 mesh sieve with n- hexane, and recovering n-hexane to obtain a semi-liquid and semi-solid paste, and put the paste in a glass sealed bottle and keep it away from light and low temperature; when the patient uses the paste, apply the umbilicus and stick moxibustion on the navel.

[0084] The glycerol extracts of peppermint and 1 part of Smilax glabra according to the above parts by weight is directly extracted by edible glycerin solution with 50% volume concentration, concentrated to one third of the original volume, sealed at 4°C and stored away from light, and then directly connected to the patient for retention enema.

[0085] Embodiment 2

[0086] For patients with hyperbolic syndrome, in addition to common abdominal pain, constipation, abdominal distension, and signs obtained from barium meal and B- ultrasound examination, for patients with liver qi stagnation, it can be seen clinically that they are grumpy, easy to provoke, or depressed and unhappy, so the number of drugs for soothing liver and breaking Qi should be increased. The traditional Chinese medicine compound composition is made of the following: 10 parts of Codonopsis pilosula 10% ethanol extract, 10 parts of Atractylodes macrocephala Koidz. 10% ethanol extract, 10 parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 40 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 5 parts of raw rhubarb, 10 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir- baked Prunus persica (peeled), 15 parts of stir-stir-fried wax gourd kernel, 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 10 parts of Patrinia herb, 10 parts of Taraxacum mongolicum, 2 parts of mirabilite, 5 parts of Corydalis yanhusuo, 2 parts of Fructus Toosendan, 5 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 5 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 4 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 2 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n-hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n-hexane extract, 1 part of peppermint glycerol extract and 1 part of Smilax glabra

[0087] The preparation method is the same as Embodiment 1.

[0088] Embodiment 3

[0089] For patients suffering from hyperbolic syndrome, in addition to common abdominal pain, constipation, abdominal distension, and signs obtained from barium meal and B-ultrasound examination, for the patients with weak temper and deficiency of both qi and blood, it can be seen clinically that they are emaciated, short of breath, pale face,

and unappealing claw nails, so the number of drugs for strengthening the spleen and nourishing blood should be increased. The traditional Chinese medicine compound composition is made of the following: 15 parts of Codonopsis pilosula 10% ethanol extract, 15 parts of Atractylodes macrocephala Koidz. 10% ethanol extract, 10 parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 40 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 5 parts of raw rhubarb, 10 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir- baked Prunus persica (peeled), 15 parts of stir-stir-fried wax gourd kernel, 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 10 parts of Patrinia herb, 10 parts of Taraxacum mongolicum, 2 parts of mirabilite, 5 parts of Corydalis yanhusuo, 2 parts of Fructus Toosendan, 5 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 5 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 4 parts of Korean pine bark ethyl acetate extract, 4 parts of Angelica sinensis ethyl acetate extract, 4 parts of Rehmannia glutinosa ethyl acetate extract, 4 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n-hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n-hexane extract, 1 part of peppermint glycerol extract and 1 part of Smilax glabra

[0090] The preparation method is the same as Embodiment 1.

[0091] Embodiment 4

[0092] For patients suffering from hyperbolic syndrome, in addition to common abdominal pain, constipation, abdominal distension, and signs obtained from barium meal and B-ultrasound examination, for the patients with weak temper and deficiency of both qi and blood, it can be seen clinically that patients with anorexia, loose stool, favor to warmth and relieved by pressing, cold pain in abdomen, favor to hot water, get warm will alleviate and get cold will aggravate should increase the number of drugs for warming and tonifying spleen and yang. The compound traditional Chinese medicine compound composition is prepared from the following components: 10 parts of Codonopsis pilosula 10% ethanol extract, 10 parts of Atractylodes macrocephala Koidz. 10% ethanol extract, parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 20 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 5 parts of raw rhubarb, 10 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir- baked Prunus persica (peeled), 15 parts of stir-stir-fried wax gourd kernel, 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 10 parts of Patrinia herb, 10 parts of Taraxacum mongolicum, 2 parts of mirabilite, 5 parts of Corydalis yanhusuo, 2 parts of Fructus Toosendan, 5 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 5 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 2 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 2 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 4 parts of cinnamon n-hexane extract, 4 parts of pepper n-hexane extract, 4 parts of Zanthoxylum bungeanum n-hexane extract, 4 parts of fennel n-hexane extract, 1 part of peppermint glycerol extract and 1 part of Smilax glabra glycerol extract.

[0093] The preparation method is the same as Embodiment 1.

[0094] Embodiment 5

[0095] For patients suffering from hyperbolic syndrome, in addition to common abdominal pain, constipation, abdominal distension, and signs obtained from barium meal and B-ultrasound examination, for the patients with large intestine fluid deficiency, it can be seen clinically that patients with hair intolerance, weak body, perennial constipation and more serious constipation after defecation with Phenolphthalein tablets and senna leaves should increase the number of drugs for warming and relaxing bowels. The traditional Chinese medicine compound composition is prepared from the following components: 10 parts of Codonopsis pilosula 10% ethanol extract, 10 parts of Atractylodes macrocephala Koidz. 10% ethanol extract, 10 parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 20 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 5 parts of raw rhubarb, 10 parts of wine-processed rhubarb, 15 parts of peony bark, 25 parts of stir-baked Prunus persica (peeled), 25 parts of stir-stir-fried wax gourd kernel, 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 10 parts of Patrinia herb, 10 parts of Taraxacum mongolicum, 2 parts of mirabilite, 5 parts of Corydalis yanhusuo, 2 parts of Fructus Toosendan, 5 parts of Magnolia officinalis, 15 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 5 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 2 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 4 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n-hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n-hexane extract, 1 part of peppermint glycerol extract and 1 part of Smilax glabra glycerol extract.

[0096] The preparation method is the same as Embodiment 1.

[0097] Embodiment 6

[0098] For patients suffering from hyperbolic syndrome, in addition to common abdominal pain, constipation, abdominal distension, and signs obtained from barium meal and B-ultrasound examination, for the patients with dry excrement, Shangrao spirit, delirium, burning sensation of large intestine, tenesmus, it can be seen clinically that they have abdominal pain, vague consciousness and burning anus, so we should increase the number of drugs for pressing down the hot knot, promoting diuresis, patting turbidity, awakening the mind and inducing resuscitation. The traditional Chinese medicine compound composition is prepared from the following: 10 parts of Codonopsis pilosula 10% ethanol extract, 10 parts of Atractylodes macrocephala Koidz. 10% ethanol extract, parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 20 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 15 parts of raw rhubarb, 5 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir- baked Prunus persica (peeled), 15 parts of stir-stir-fried wax gourd kernel, 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 10 parts of Patrinia herb, 15 parts of Taraxacum mongolicum, 10 parts of mirabilite, 5 parts of Corydalis yanhusuo, 2 parts of Fructus Toosendan, 15 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 5 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 2 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 2 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n-hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n-hexane extract, 4 parts of peppermint glycerol extract and 4 parts of Smilax glabra glycerol extract.

[0099] The preparation method is the same as Embodiment 1.

[0100] Embodiment 7

[0101] For patients suffering from hyperbolic syndrome, in addition to common abdominal pain, constipation, abdominal distension, and signs obtained from barium meal and B-ultrasound examination, in view of the stagnation of damp-heat in the gallbladder, the turning of liquid into stone, clinically visible abdominal pain, tenderness and rebound pain at McBurney's point, we should increase the number of drugs for clearing damp-heat and promoting gallbladder digestion. The compound traditional Chinese medicine compound composition is prepared from the following components: 10 parts of Codonopsis pilosula 10% ethanol extract, 10 parts of Atractylodes macrocephala Koidz. 10% ethanol extract, 10 parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 20 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 15 parts of raw rhubarb, 5 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir-baked Prunus persica (peeled), 15 parts of stir-stir-fried wax gourd kernel. 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 15 parts of Patrinia herb, 15 parts of Taraxacum mongolicum, 6 parts of mirabilite, 5 parts of Corydalis yanhusuo, 10 parts of Fructus Toosendan, 15 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 15 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 10 parts of Radix Paeoniae Alba, 2 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 2 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n- hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n- hexane extract, 4 parts of peppermint glycerol extract and 4 parts of Smilax glabra glycerol extract.

[0102] The preparation method is the same as Embodiment 1.

[0103] Embodiment 8

[0104] For patients suffering from hyperbolic syndrome, in addition to common abdominal pain, constipation, abdominal distension, and signs obtained from barium meal and B-ultrasound examination, aiming at the cough caused by the obstruction of fu- organs-qi, the cough caused by the upward reverse movement of qi, and the vomiting caused by stomach qi upward reversal, it is necessary to add the amount of drugs for calming down the down-qi, eliminating phlegm and relieving cough, promoting qi circulation and stopping vomiting. The compound traditional Chinese medicine compound composition is prepared from the following components: 10 parts of Codonopsis pilosula 10% ethanol extract, 10 parts of Atractylodes macrocephala Koidz. 10% ethanol extract, 15 parts of Folium Perillae, 10 parts of Pinellia ternata, 35 parts of Perilla frutescens, 20 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 15 parts of raw rhubarb, 5 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir-baked Prunus persica (peeled), 15 parts of stir-stir-fried wax gourd kernel. 10 parts of Fructus Aurantii Immaturus, 10 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 15 parts of Patrinia herb, 15 parts of Taraxacum mongolicum, 2 parts of mirabilite, 5 parts of Corydalis yanhusuo, 6 parts of Fructus Toosendan, 15 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 15 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 25 parts of Cinnamomum cassia Presl, 20 parts of Radix Paeoniae Alba, 2 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 2 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n- hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n- hexane extract, 4 parts of peppermint glycerol extract and 4 parts of Smilax glabra glycerol extract.

[0105] The preparation method is the same as Embodiment 1.

[0106] Embodiment 9 Clinical trials

[0107] 1. Clinical cases: Among 87 patients suffering from liver (spleen) curvature syndrome, 2 patients aged 21-9 years, accounting for 2.29%; 57 cases (65.51%) aged from 30 to 56 years old; 28 cases (32.18%) are aged from 7 to 83 years.

[0108] 2. Drug to be tested: the traditional Chinese medicine compound composition prepared in Embodiment 1 of the present invention.

[0109] 87 patients suffering from liver (spleen) curvature syndrome took the traditional Chinese medicine compound composition prepared in Embodiment 1 of the present invention. Twice a day, 4 cases (4.59%) were cured after 8-12 days of treatment, 38 cases (43.67%) recovered in 13-21 days. 13 cases (14.94%) recovered in 29 days, and 21 cases (24.13%) recovered in 30-36 days; taking the medicine can relieve symptoms, and 8 patients were the same as the original after stopping taking the medicine for 2 days; these patients were cured within half a year after taking the Chinese medicine composition intermittently, accounting for 9.19%; because 3 patients were unwilling to insist on taking medicine, the drug use was ineffective, and the clinical symptoms disappeared after surgical treatment. However, after 5 years' follow-up, the patient's immunity 1s low, one patient coughs all the year round, one patient often suffers from insomnia after hand operation, and one patient is accompanied by intestinal adhesion after operation. Specific evaluation of curative effect before and after treatment is shown in Table 1:

[0110] Table 1 87 patients with liver (spleen) curvature syndrome before and after treatment

Some patients were accompanied by cough, vomiting caused by biliary calculus, yellow-green vomit.

colon are | reduced, reduced, but it slightly, similar to | was moderately to | normal significantly severely intestinal tract. | different from dilated, normal colon. distended and accumulated feces, accompanied by the long and tortuous transverse colon, and the middle part drops to the pelvic cavity in a big "un shape. B- Some patients | After taking | After taking | It is the same ultrasonography | have unsmooth | Chinese the Chinese | as before of gallbladder gallbladder medicine medicine treatment after wall and | Paishi Paishi taking Chinese gallstones Decoction, the | Decoction, the | medicine stones big stones | Paishi disappeared. decreased and | Decoction. the small stones disappeared.

[0112]

[0113] The results of the above clinical experiments show that the traditional Chinese medicine compound composition provided by the invention adopts the theory of syndrome differentiation and treatment, combines the pathogenesis of liver (spleen) curvature syndrome, screens out the best component ratio through a large number of experiments, and optimizes the best preparation process through a large number of experiments. The traditional Chinese medicine compound composition provided by the invention has the advantages of soothing the liver, regulating qi, relaxing the intestine and promoting qi circulation, nourishing blood and moistening the intestine, strengthening the spleen to eliminate turbidity, eliminating phlegm and resolving hard masses. It has a good therapeutic effect on liver curvature and spleen curvature syndrome, with high cure rate, low adverse reactions and good clinical medication safety.

[0114] The above is only the preferred embodiment of the present invention, and it should be pointed out that for ordinary technicians in the technical field, without departing from the principles and concepts of the present invention, several improvements and embellishments can be made, which should also be regarded as the protection scope of the present invention.

Claims

1. A traditional Chinese medicine compound composition for treating hyperbolic syndrome, which is characterized in that it is prepared from the following raw materials in parts by weight: 10-30 parts of Codonopsis pilosula extract, 10-30 parts of Atractylodes macrocephala Koidz. extract, 10-20 parts of Folium Perillae and 10-20 parts of Pinellia ternata, 30-90 of parts Perilla frutescens, 20-40 parts of Citri Reticulatae Viride Pericarpium, 15-30 parts of Lindera aggregata, 5-10 parts of raw rhubarb, 10-15 parts of wine-processed rhubarb, 10-25 parts of peony bark, 10-15 parts of stir-baked Prunus persica, 10-25 parts of stir-fried wax gourd kernel, 10-25 parts of Fructus Aurantii Immaturus, 10-15 parts of Fructus Aurantii, 5-10 parts of Curcuma phaeocaulis Valeton, 10-25 parts of Patrinia herb, 10-25 parts of Taraxacum mongolicum, 1-10 parts of mirabilite, 1-25 parts of Corydalis yanhusuo, 1-5 parts of Fructus Toosendan, 1-15 parts of Magnolia officinalis, 10-35 parts of fried Semen Trichosanthis, 10-35 parts of Massa Medicata Fermentata, 10-35 parts of malt, 5-35 parts of Radix Curcumae 15-45 parts of Cimicifuga rhizome, 5- 35 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 2-8 parts of Korean pine bark ethyl acetate extract, 2-8 parts of Angelica sinensis ethyl acetate extract, 2-8 parts of Rehmannia glutinosa ethyl acetate extract, 2-8 parts of jujube ethyl acetate extract, 2-8 parts of cinnamon n-hexane extract, 1-8 parts of pepper n-hexane extract, 1-8 parts of Zanthoxylum bungeanum n-hexane extract, 1-5 parts of fennel n-hexane extract, 1-5 parts of peppermint glycerol extract and 1-10 parts of Smilax glabra glycerol extract.

2. The traditional Chinese medicine compound composition for treating hyperbolic syndrome according to claim 1, which is characterized in that it is made of the following raw materials in parts by weight: parts of Codonopsis pilosula extract, 10 parts of Atractylodes macrocephala Koidz. extract, 10 parts of Folium Perillae, 10 parts of Pinellia ternata, 30 parts of Perilla frutescens, 20 parts of Citri Reticulatae Viride Pericarpium, 20 parts of Lindera aggregata, 5 parts of raw rhubarb, 10 parts of wine-processed rhubarb, 15 parts of peony bark, 15 parts of stir-baked Prunus persica, 15 parts of stir-stir-fried wax gourd kernel, 15 parts of Fructus Aurantii Immaturus, 15 parts of Fructus Aurantii, 5 parts of Curcuma phaeocaulis Valeton, 10 parts of Patrinia herb, 10 parts of Taraxacum mongolicum, 2 parts of mirabilite, 5 parts of Corydalis yanhusuo, 2 parts of Fructus Toosendan, 5 parts of Magnolia officinalis, 10 parts of fried Semen Trichosanthis, 10 parts of Massa Medicata Fermentata, 10 parts of malt, 5 parts of Radix Curcumae, 5 parts of Cimicifuga rhizome, 5 parts of Cinnamomum cassia Presl, 5-35 parts of Radix Paeoniae Alba, 2 parts of Korean pine bark ethyl acetate extract, 2 parts of Angelica sinensis ethyl acetate extract, 2 parts of Rehmannia glutinosa ethyl acetate extract, 2 parts of jujube ethyl acetate extract, 1 part of cinnamon n-hexane extract, 1 part of pepper n-hexane extract, 1 part of Zanthoxylum bungeanum n-hexane extract, 1 part of fennel n-hexane extract, 1 part of peppermint glycerol extract and 1 part of Smilax glabra glycerol extract.

3. The traditional Chinese medicine compound composition for treating hyperbolic syndrome according to claim 1 or 2, which is characterized in that, the Codonopsis pilosula extract and Atractylodes macrocephala Koidz. extract are prepared by the following methods: taking Codonopsis pilosula and Atractylodes macrocephala Koidz., respectively, adding 10% ethanol for reflux extraction for 1-3 times, each time for 30-120 minutes, combining the extracts, and concentrating to obtain extract.

4. The traditional Chinese medicine compound composition for treating hyperbolic syndrome according to claim 1 or 2, which is characterized in that, the Korean pine bark ethyl acetate extract, the Angelica sinensis ethyl acetate extract, the Rehmannia glutinosa ethyl acetate extract and the jujube ethyl acetate extract are prepared by the following methods: respectively taking Korean pine bark, Angelica sinensis, Rehmannia glutinosa and jujube, crushing them with a 40 mesh sieve, and extracting them with 60% ethanol for 3 times, each time for 30 to 60 minutes; recovering the ethanol, then extracting them with n-hexane, dichloromethane and ethyl acetate, taking the ethyl acetate extract, and distilling them under reduced pressure to obtain the ethyl acetate extract.

5. The traditional Chinese medicine compound composition for treating hyperbolic syndrome according to claim 1 or 2, which is characterized in that cinnamon n-hexane extract, pepper n-hexane extract, Zanthoxylum bungeanum n-hexane extract and fennel n- hexane extract are prepared by the following methods: crushing cinnamon, pepper, Zanthoxylum bungeanum and fennel respectively, sieving with a 40 mesh sieve, then refluxing and extracting with n-hexane for 1-3 times, each time for 30-60 minutes,

recovering n-hexane, and obtaining the n-hexane extracts of cinnamon, pepper, Zanthoxylum bungeanum and fennel respectively.

6. The traditional Chinese medicine compound composition for treating hyperbolic syndrome according to claim 1 or 2, which is characterized in that, the peppermint glycerol extract and Smilax glabra glycerol extract are prepared by the following methods: respectively taking peppermint and Smilax glabra, crushing and sieving with a 40 mesh sieve, then ultrasonically extracting with 50% glycerol aqueous solution for 1-3 times, each time for 30-120 minutes, combining the extracts, and concentrating to obtain extract.

7. A preparation method of traditional Chinese medicine compound composition for treating hyperbolic syndrome according to claim 1 or 2, which comprises the following steps: (1) according to the weight parts of claim 1 or 2, taking Folium Perillae, Pinellia ternata, Perilla frutescens, Citri Reticulatae Viride Pericarpium, Lindera aggregata, raw rhubarb, wine-processed rhubarb, peony bark, stir-baked Prunus persica, stir-stir-fried wax gourd kernel, Fructus Aurantii Immaturus, Fructus Aurantii, Patrinia herb, Taraxacum mongolicum, mirabilite, Corydalis yanhusuo, Fructus Toosendan, Magnolia officinalis, fried Semen Trichosanthis, Massa Medicata Fermentata, malt, Radix Curcumae, Cimicifuga rhizome, Cinnamomum cassia Presl, and Radix Paeoniae Alba, pulverizing, sieving with 40 mesh sieve, and then adding 20%-40% volume ethanol for ultrasonic extraction for 2-3 times, 2-3 hours each time; after solid-liquid centrifugation, obtaining the supernatant, concentrating and obtaining the extract, which is used for standby; (2) according to the weight parts of claim 1 or 2, taking Korean pine bark, Angelica sinensis, Rehmannia glutinosa and jujube by weight, crushing them with 40 mesh sieve, first extracting them with 60% ethanol for 2-3 times, each time for 30-60 minutes, recovering the ethanol, then extracting them with n-hexane, dichloromethane and ethyl acetate in turn, taking the ethyl acetate extract, distilling under reduced pressure to obtain ethyl acetate extract, mixing with soluble edible starch and freeze-drying to obtain the extract, (3) taking cinnamon, pepper, Zanthoxylum bungeanum and fennel according to the weight parts of claim 1 or 2, crushing and sieving with a 40 mesh sieve, then reflux-

extracting them with n-hexane for 1-3 times, each time for 30-60 minutes, and recovering the n-hexane to obtain n-hexane extracts of cinnamon, pepper, Zanthoxylum bungeanum and fennel; (4) according to the parts by weight of claim 1 or 2, taking peppermint and Smilax glabra, crushing them with a 40 mesh sieve, and then ultrasonically extracting them with 50% glycerin aqueous solution of food grade to obtain glycerol extracts of peppermint and Smilax glabra, (5) according to the parts by weight of claim 1 or 2, adding Codonopsis pilosula and Atractylodes macrocephala Koidz. with 10% ethanol for reflux extraction for 2-3 times, each time for 30-60 minutes, and concentrating the extract to obtain the extract; (6) preparing the extract obtained in step (1), the freeze-dried powder obtained in step (2), the glycerol extracts of peppermint and Smilax glabra obtained in step (4), the extracts of Codonopsis pilosula and Atractylodes macrocephala Koidz. obtained in step (5) and pharmaceutically acceptable carriers into traditional Chinese medicine preparations; the n-hexane extracts of cinnamon, pepper, Zanthoxylum bungeanum and fennel obtained in step (3) are applied to navel.

8. The preparation method of traditional Chinese medicine compound composition for treating hyperbolic syndrome according to claim 1 or 2, which is characterized in that the traditional Chinese medicine preparation is granule, tablet, capsule, oral liquid or dripping pill.

9. An application of the traditional Chinese medicine compound composition for treating hyperbolic syndrome according to claim 1 or 2 in preparing medicine for treating hyperbolic syndrome.