CN102949662B - External traditional Chinese medicine preparation for treating female reproductive system inflammation and preparation method thereof - Google Patents

External traditional Chinese medicine preparation for treating female reproductive system inflammation and preparation method thereof Download PDF

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CN102949662B
CN102949662B CN201210419135.2A CN201210419135A CN102949662B CN 102949662 B CN102949662 B CN 102949662B CN 201210419135 A CN201210419135 A CN 201210419135A CN 102949662 B CN102949662 B CN 102949662B
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fructus
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CN102949662A (en
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马南行
李超
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马南行
李超
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Abstract

The invention provides an external traditional Chinese medicine preparation for treating female reproductive system inflammation and a preparation method thereof. The traditional Chinese medicine preparation consists of the following raw materials, by weight: 28-32 parts of Fructus Cnidii, 28-32 parts of Sophora flavescens, 28-32 parts of fructus kochiae, 28-32 parts of rose, 28-32 parts of zedoary, 28-32 parts of gallnut, 28-32 parts of raspberry, 13-17 parts of golden cypress, 13-17 parts of tuckahoe, and 13-17 parts of pepper. The external traditional Chinese medicine preparation for treating female reproductive system inflammation provided by the invention has good curative effects on vulvitis, vaginitis, trichomonas vaginitis, fungal vaginitis, senile vaginitis, cervical erosion, pelvic inflammation, and female sexual apathy. The invention has advantages of scientific components, carefully drug selection, easily available medicinal materials, mild drug properties, and no side effect.

Description

A kind of Chinese medicine for outer use that is used for the treatment of female genital disease and preparation method thereof
Technical field
The external application Chinese medicine field that gynecological's compositions belongs to gynecological is nursed one's health in a kind of external that the present invention proposes, and is specifically related to a kind of Chinese medicine for outer use that is used for the treatment of female genital disease.
Background technology
Special construction due to female reproductive system, with the difference in daily physiological hygiene protection, very easily cause cross infection, cause the invasion and attack of the microorganism of curing the disease and cause inflammation in various degree, as vulvitis, vaginitis, trichomonal vaginitis, colpitis mycotica, senile vaginitis, cervical erosion, pelvic inflammation, female frigidity etc.At present this sick sickness rate rises year by year, and age of onset has trend in advance, and the feature that this type of disease is multiple, relapse rate is high, has caused serious impact to numerous women's healthy and quality of life.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine for outer use that is used for the treatment of female genital disease and preparation method thereof.
The Chinese medicine for outer use that is used for the treatment of female genital disease of the present invention, crude drug by following weight parts forms: Fructus Cnidii, Radix Sophorae Flavescentis, the Fructus Kochiae, Flos Rosae Rugosae, Rhizoma Curcumae, Galla Chinensis, each 28-32 part of Fructus Rubi, Cortex Phellodendri, Rhizoma Smilacis Glabrae, each 13-17 part of Pericarpium Zanthoxyli.
Preferably, described in be used for the treatment of the Chinese medicine for outer use of female genital disease, by the crude drug of following weight parts, formed: each 30 parts of Fructus Cnidiis, Radix Sophorae Flavescentis, the Fructus Kochiae, Flos Rosae Rugosae, Rhizoma Curcumae, Galla Chinensis, Fructus Rubi, each 15 parts of Cortex Phellodendris, Rhizoma Smilacis Glabrae, Pericarpium Zanthoxyli.
Wherein, the effect of Fructus Cnidii: have warming the kidney to invigorate YANG, dampness, dispels the wind, the effect of parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
The effect of Radix Sophorae Flavescentis: heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery; Discharging fresh blood stool; Jaundice; Dysuria; Edema; Leukorrhagia; Pudendal pruritus; Scabies; Leprosy; Skin pruritus; Noxious dampness skin infection.Pudendal pruritus under treatment belt.To women's leucorrhea with yellow discharge, and male's swelling of the vulva pudendal pruritus all has good therapeutical effect.
The effect of the Fructus Kochiae: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus, diuresis, clearing away damp-heat.Control dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, pudendum pruritus due to damp pathogen.
The effect of Flos Rosae Rugosae: promoting QI circulation for relieving depression, and blood, pain relieving.For stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, falls and flutters the pain of injury.There is strong liver and nourishing stomach, promoting blood flow to regulate menstruation, loosening bowel to relieve constipation, the effect of resolving stagnation for tranquilization, can chill out, balance endocrine, the gas of enriching blood, liver and stomach be had to the effect of conditioning, the emotion of releiving and have anti-inflammation and sterilization, allaying tiredness, improve body constitution, the effect of moist skin.
The function of Rhizoma Curcumae cures mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
Gallic effect: astringe the lung; Hidroschesis; Astringing intestine to stop diarrhea; Controlling nocturnal emission with astringent drugs; Hemostasis; Removing toxic substances chronic cough of deficiency lung; Spontaneous sweating; Chronic dysentery chronic diarrhea; Proctoptosis; Seminal emission; Nebulousurine; Various hemorrhage; Carbuncle furuncle.
The effect of Fructus Rubi: the liver and the kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, improving eyesight, impotence and premature ejaculation, emission and spermatorrhea, cold womb is infertile, and leukorrhagia is rare clearly, frequent micturition incontinence of urine, blurred vision is dark, early whitening of beard and hair.
The effect of Cortex Phellodendri: heat clearing away, dampness, pathogenic fire purging, removing toxic substances.Control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice, flaccidity is preesed, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.
The effect of Rhizoma Smilacis Glabrae: control syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, treats furuncle, carbuncle, scrofula, the limbs contracture due to syphilis and mercurialism, bones and muscles pain, removing toxic substances, dehumidifying, sharp joint.
The effect of Pericarpium Zanthoxyli: warming middle-JIAO to relieve pain; Dehumidifying antidiarrheal; Killing parasites for relieving itching.The coldness and pain in the epigastrium of main Deficiency and coldness of spleen and stomach; Ascarid stomachache; Vomiting is had loose bowels; Lung cold cough with asthma; Lung cold cough with asthma; Toothache due to dental caries; Pudendal pruritus leukorrhagia; Eczema skin pruritus.
The above-mentioned preparation method that is used for the treatment of the Chinese medicine for outer use of female genital disease, comprises the steps:
(1) by formula, take each crude drug, after grinding, sieving, by each crude drug fine powder mixing and stirring;
(2) in step (1) crude drug fine powder, add the alcoholic solution of 2-3 times of volume 60-80%, ultrasonic extraction;
(3) extracting solution that step (2) obtains reclaims ethanol extremely without alcohol taste, then through microfiltration hollow fiber microfiltration membrane machine and ultrafiltration hollow fiber ultrafiltration membrane machine, filters successively, removes the impurity in medicinal liquid, obtains pure medicinal liquid.
Beneficial effect of the present invention is:
The Chinese medicine for outer use that is used for the treatment of female genital disease of the present invention has good curative effect to vulvitis, vaginitis, trichomonal vaginitis, colpitis mycotica, senile vaginitis, cervical erosion, pelvic inflammatory disease, female frigidity etc.Chinese medicine preparation compatibility science of the present invention, selects YAOJING thin, and the property of medicine is gentle, can not have side effects.
The specific embodiment
Below in conjunction with the specific embodiment, the present invention is described in further detail, but do not form any limitation of the invention, and the change of the limited number of time that anyone does within the scope of the claims in the present invention, still in claim protection domain of the present invention.
Embodiment 1
A Chinese medicine for outer use that is used for the treatment of female genital disease, is comprised of the crude drug of following weight parts: each 30 parts of Fructus Cnidiis, Radix Sophorae Flavescentis, the Fructus Kochiae, Flos Rosae Rugosae, Rhizoma Curcumae, Galla Chinensis, Fructus Rubi, each 15 parts of Cortex Phellodendris, Rhizoma Smilacis Glabrae, Pericarpium Zanthoxyli.
Embodiment 2
A Chinese medicine for outer use that is used for the treatment of female genital disease, is comprised of the crude drug of following weight parts: each 28 parts of Fructus Cnidiis, Radix Sophorae Flavescentis, the Fructus Kochiae, Flos Rosae Rugosae, Rhizoma Curcumae, Galla Chinensis, Fructus Rubi, each 13 parts of Cortex Phellodendris, Rhizoma Smilacis Glabrae, Pericarpium Zanthoxyli.
Embodiment 3
A Chinese medicine for outer use that is used for the treatment of female genital disease, is comprised of the crude drug of following weight parts: each 28 parts of Fructus Cnidiis, Radix Sophorae Flavescentis, the Fructus Kochiae, Flos Rosae Rugosae, Rhizoma Curcumae, Galla Chinensis, Fructus Rubi, each 17 parts of Cortex Phellodendris, Rhizoma Smilacis Glabrae, Pericarpium Zanthoxyli.
Embodiment 4
A kind of Chinese medicine for outer use that is used for the treatment of female genital disease, crude drug by following weight parts forms: respectively 32 parts of 28 parts of Fructus Cnidiis, 30 parts of Radix Sophorae Flavescentiss, 30 parts of the Fructus Kochiae, 28 parts of Flos Rosae Rugosaes, Rhizoma Curcumae, Galla Chinensis, Fructus Rubies, 13 parts of Cortex Phellodendris, 15 parts of Rhizoma Smilacis Glabraes, 17 parts, Pericarpium Zanthoxyli.
Embodiment 5
A Chinese medicine for outer use that is used for the treatment of female genital disease, is comprised of the crude drug of following weight parts: each 32 parts of Fructus Cnidiis, Radix Sophorae Flavescentis, the Fructus Kochiae, Flos Rosae Rugosae, Rhizoma Curcumae, Galla Chinensis, Fructus Rubi, each 17 parts of Cortex Phellodendris, Rhizoma Smilacis Glabrae, Pericarpium Zanthoxyli.
The preparation method of the Chinese medicine for outer use that is used for the treatment of female genital disease of embodiment 1-4, comprises the steps:
In between GMP standard vehicle, by component ratio, take each crude drug, add in clean container, grind, with 400 mesh sieves, sieve, draw fine powder, then by material loading mix and blend, add the alcoholic solution of 2-3 times of volume 75%, with Chinese medicine extraction ultrasound wave thickener, carry out ultrasonic extraction, 40-80kHZ, temperature is 60-65 ℃, extracts 30min; Extracting solution reclaims ethanol extremely without alcohol taste through Rotary Evaporators, then staticly settle, via hole diameter is that the hollow fiber microfiltration membrane of 10 μ m and the hollow fiber ultrafiltration membrane of 0.02 μ m are filtered again, directly removes the starch in medicinal liquid, natural gum, pectin, lymphatic temperament, protein, antibacterial, virus waits macromole impurity, obtains pure concentrated medicament.
Also can adopt conventional method as required, compositions be made to the dosage forms such as cream, emulsion.
By after this product dilute with water, clean patient's pudendum, and by irrigator, the medicinal liquid after dilution is delivered to patient's vagina deep washing vagina, every day 1 time, within 7 days, be a course for the treatment of.Female vulva inflammation, vaginitis, trichomonal vaginitis, colpitis mycotica, senile vaginitis, cervical erosion, pelvic inflammatory disease, female frigidity etc. are had to good curative effect.
Clinical case:
Case 1: patient Ms Zhang, 40 years old, suffer from trichomonal vaginitis, obstinate, the medication of suiting the medicine to the illness is used the medicinal liquid of the embodiment of the present invention 1 and is cleaned pudendum after two courses for the treatment of, and symptom obviously slows down; Continue to use after 2 courses for the treatment of, pudendum sense of discomfort disappears, and exotocrine is normal, without infusorian, makes a definite diagnosis recovery from illness.
Case 2: patient Huang Nvshi, 42 years old, suffers from bacterial infection pelvic inflammatory disease, with symptoms such as lower abdominal pain heating, abdominal tenderness, inappetence, use the lotion of the embodiment of the present invention 1 and clean pudendum, after 1 curative effect, occur the improvement of clinical setting, as bring down a fever, abdominal tenderness or rebound tenderness alleviate.Continue to use after 1 week and again screen infection pathogen, make a definite diagnosis recovery from illness.
Case 3: patient's CHENNU scholar, 35 years old, suffer from colpitis mycotica, there is pruritus and pain in pudendum, or has burning sensation.Use the medicinal liquid of the embodiment of the present invention 2 after 2 courses for the treatment of, malaise symptoms makes moderate progress, and continues to use after 2 courses for the treatment of, makes a definite diagnosis recovery from illness.
Case 4: patient Tan Nvshi, 40 years old, suffer from cervicitis, main manifestations is leucorrhoea grow in quantity, is purulence, intermenstrual bleeding.Use the medicinal liquid of the embodiment of the present invention 5 after 2 courses for the treatment of, symptom is alleviated to some extent, continues to use after 3 courses for the treatment of, makes a definite diagnosis recovery from illness.

Claims (4)

1. a Chinese medicine for outer use that is used for the treatment of female genital disease, it is characterized in that, crude drug by following weight parts forms: respectively 30 parts of Fructus Cnidii, Radix Sophorae Flavescentis, the Fructus Kochiae, Flos Rosae Rugosae, Rhizoma Curcumae, Galla Chinensis, Fructus Rubies, respectively 15 parts, Cortex Phellodendri, Rhizoma Smilacis Glabrae, Pericarpium Zanthoxyli.
2. the Chinese medicine for outer use that is used for the treatment of female genital disease according to claim 1, is characterized in that, described preparation can be cream, emulsion, water preparation.
3. the preparation method that is used for the treatment of the Chinese medicine for outer use of female genital disease claimed in claim 1, is characterized in that, comprises the steps:
(1) by formula, take each crude drug, after grinding, sieving, by each crude drug fine powder mixing and stirring;
(2) in step (1) crude drug fine powder, add the alcoholic solution of 2-3 times of volume 60-80%, ultrasonic extraction;
(3) extracting solution that step (2) obtains reclaims ethanol extremely without alcohol taste, more separated through secondary filter net filtration, removes the impurity in medicinal liquid, obtains pure medicinal liquid.
4. the preparation method that is used for the treatment of the Chinese medicine for outer use of female genital disease according to claim 3, is characterized in that, sieving described in step (1) referred to 400 mesh sieves.
CN201210419135.2A 2012-10-29 2012-10-29 External traditional Chinese medicine preparation for treating female reproductive system inflammation and preparation method thereof Active CN102949662B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103239676B (en) * 2013-04-22 2015-06-24 马南行 Topical pharmaceutical composition for preventing and treating bacterial vaginosis
CN103751587A (en) * 2013-12-31 2014-04-30 余姚市朗霞街道飞达冲件厂 Preparation method of medicine for treating senile vaginitis of workwomen in plastic making plants
CN108126162A (en) * 2018-02-26 2018-06-08 高俊山 A kind of bath steaming health care Chinese medicine bag

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CN1325111C (en) * 2004-07-08 2007-07-11 黄文峰 Traditional Chinese medicine composition for treating colpitis and cervicitis, prepn. method and quality standard therefor
CN1742938A (en) * 2005-09-23 2006-03-08 北京润德康医药技术有限公司 Lifukang medicine for vagina and preparing method thereof

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