CN105250622A - Traditional Chinese medicine capsules for treating endocrine dyscrasia and preparation method thereof - Google Patents
Traditional Chinese medicine capsules for treating endocrine dyscrasia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine capsules for treating endocrine dyscrasia and a preparation method thereof. The traditional Chinese medicine capsules are prepared from, by weight, 20-30 parts of leonurus, 15-25 parts of akebia fruits, 10-20 parts of Chinese dates, 10-20 parts of semen sesami nigrum, 8-16 parts of fructus crataegi cuneatae, 5-15 parts of agaric, 5-15 parts of white fungus, 5-15 parts of selaginella tamariscina, 4-12 parts of semen juglandis, 4-12 parts of semen allii tuberose, 2-8 parts of seeds of bird rape and 1-5 parts of China roses. The common traditional Chinese medicine materials are adopted as raw materials of the traditional Chinese medicine capsules, the formulation is scientific, preparation is easy, the curative effect is remarkable, no side effect exists, carrying is convenient, taking is convenient, cost is low, the effects of enriching blood and tonifying qi, reinforcing the kidney and regulating menstruation, soothing the liver-qi stagnation and nourishing yin and the stomach are achieved, and endocrine dyscrasia can be effectively treated.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicinal capsule for the treatment of endocrine disturbance and preparation method thereof.
Background technology
Hormonal system is many physiological activities such as participate in regulating the metabolic process of human body, growth promoter, reproduction old and feeble and biosis, and collaborative various ferment (biochemical enzymes) maintains the relative stability of human internal environment, to adapt to inside and outside change complicated and changeable.The various hormones of hormonal system secretion keep balance under normal circumstances, if made this balance break (certain hormonosis or very few) because of the factor of the aspects such as certain physiology, nutrition, emotion and environment, will cause endocrine disturbance.
May there is endocrine disturbance in women and male.Female endocrine dyscrasia generally there will be skin and worsens, short-tempered, endometriosis, menstrual blood volume are irregular, dysmenorrhea, menoxenia, fat, infertile, distending pain of the breast, cyclomastopathy, hirsutism, the symptoms such as poliosis senilism.Male endocrine imbalance generally there will be testis cryptorrhea pathological changes, adrenal gland diseases, thyroid disease, the symptoms such as hypophysis pathological changes, has a strong impact on genital orgnas,male and grows, even cause male sterility.
From doctor trained in Western medicine, the Therapeutic Principle of endocrine disturbance wants endocrine regulation exactly, makes endocrine again reach the mark of balance.And for the situation that each patient is different, have different Therapeutic Method.But western medical treatment endocrine disturbance needs Long-term taking medicine, side effect is large, and dependency is strong, cure rate is low.From the traditional Chinese medical science, endocrine disturbance is the performance of the deficiency of YIN, is to be retarded by silt by QI and blood caused.Congestion is detained in body, venation is obstructed, outer poison invasion human body, lochiostasis etc. all may cause that QI and blood is retarded by silt.Therefore, treat these diseases, will start with from endocrine regulation, make QI and blood unobstructed, make essence and blood nourish whole body, blood circulation promoting, comprehensive conditioning from inside to outside.
Summary of the invention
An object of the present invention overcomes the deficiencies in the prior art, provide a kind of prepare simple, evident in efficacy, have no side effect, be easy to carry, the Chinese medicinal capsule of the treatment endocrine disturbance of taking convenience.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is:
Treat an endocrine disturbance's Chinese medicinal capsule, take off the raw material of Chinese medicine stating weight proportion and be prepared from: Herba Leonuri 20-30 part, Fructus Akebiae 15-25 part, Fructus Jujubae 10-20 part, Semen Sesami Nigrum 10-20 part, Fructus Crataegi cuneatae 8-16 part, Auricularia 5-15 part, Tremella 5-15 part, Herba Selaginellae 5-15 part, Semen Juglandis 4-12 part, Semen Allii Tuberosi 4-12 part, Semen Brassicae Campestris 2-8 part, Flos Rosae Chinensis 1-5 part.
A kind of Chinese medicinal capsule for the treatment of endocrine disturbance, preferred scheme, takes off the raw material of Chinese medicine stating weight proportion and is prepared from: Herba Leonuri 23-27 part, Fructus Akebiae 18-22 part, Fructus Jujubae 14-16 part, Semen Sesami Nigrum 14-16 part, Fructus Crataegi cuneatae 10-14 part, Auricularia 8-12 part, Tremella 8-12 part, Herba Selaginellae 8-12 part, Semen Juglandis 6-10 part, Semen Allii Tuberosi 6-10 part, Semen Brassicae Campestris 4-6 part, Flos Rosae Chinensis 2-4 part.
A kind of Chinese medicinal capsule for the treatment of endocrine disturbance, preferred scheme, takes off the raw material of Chinese medicine stating weight proportion and is prepared from: Herba Leonuri 25 parts, Fructus Akebiae 20 parts, 15 parts, Fructus Jujubae, Semen Sesami Nigrum 15 parts, Fructus Crataegi cuneatae 12 parts, 10 parts, Auricularia, 10 parts, Tremella, Herba Selaginellae 10 parts, Semen Juglandis 8 parts, Semen Allii Tuberosi 8 parts, Semen Brassicae Campestris 5 parts, Flos Rosae Chinensis 3 parts.
Another object of the present invention is to provide the preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance.
Treat a preparation method for the Chinese medicinal capsule of endocrine disturbance, step is as follows:
Step one: after Fructus Jujubae (pitted), Semen Sesami Nigrum, Semen Juglandis cleaning are dried, be placed in respectively in the hot pot of 40-50 DEG C, use slow fire parch, wait to fry to Fructus Jujubae and the micro-yellow of Semen Juglandis crust, Semen Sesami Nigrum has cracker, when having fragrance to overflow, take out, be ground into 80 object fine powders;
Step 2: by dry tremella, the dried Auricularia warm water soaking 5-15 minute of 30-40 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in fill concentration be the white sugar water of 40% container in soak 10 minutes, drain away the water;
Step 3: Herba Leonuri, Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Semen Allii Tuberosi, Semen Brassicae Campestris, Flos Rosae Chinensis are cleaned up, dry, after being crushed to 40 orders, adding raw material weight 2-6 times volume fraction is the ethanol of 85%-95%, soak 10-20min, ultrasonic temperature 40 DEG C, after extracting 20-40min under ultrasonic power 60W condition, obtain ethanol extract, under 60 DEG C of conditions, be evaporated to the extractum of relative density 1.20;
Step 4: by the Fructus Jujubae of step one, Semen Sesami Nigrum, Semen Juglandis fine powder, the Tremella that step 2 obtains, Auricularia are ground into 80-120 object fine powder, incapsulate and obtain capsule finished product after mixing.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance, step 2 is by dry tremella, the dried Auricularia warm water soaking 8-12 minute of 33-37 DEG C; Preferably, by dry tremella, the dried Auricularia warm water soaking 10 minutes of 35 DEG C.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance, it is the ethanol of 88%-92% that step 3 adds raw material weight 3-5 times volume fraction, soaks 14-16min, ultrasonic temperature 40 DEG C, after extracting 25-35min under ultrasonic power 60W condition, obtain ethanol extract; Preferably, adding raw material weight 4 times of volume fractions is the ethanol of 90%, soaks 15min, ultrasonic temperature 40 DEG C, after extracting 30min, obtains ethanol extract under ultrasonic power 60W condition.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance, step 4 dry, pulverize into 90-110 object fine powder at 53-57 DEG C; Preferably, at 55 DEG C, dry, pulverize into 100 object fine powders.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Leonuri: cold nature, bitter in the mouth, pungent.Return Liver Channel, heart channel, urinary bladder channel.Effect and effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.With controlling the dysmenorrhea of women's blood stasis, amenorrhea, blockage of menstruation, postpartum stagnation stomachache; Edema, dysuria etc.
Fructus Akebiae: cold in nature, bitter in the mouth.Return Liver Channel, gallbladder meridian, stomach warp, urinary bladder channel.Effect and effect: depressed liver-energy dispersing and QI regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Belong to QI regulating medicine.Food, lumbago, hypochondriac pain, hernia, dysmenorrhea, uterine prolapse, excessive thirst, ureteral calculus is not thought by treating the liver peratodynia, gastric heat.
Fructus Jujubae: warm in nature, sweet in the mouth.Return spleen channel, stomach warp, heart channel.Effect and effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Belong to the Qi-tonifying drug of qi-restoratives medicine subordinate classification.With controlling insufficiency of the spleen lack of appetite, qi-blood-body fluid deficiency, weak loose stool, married woman are dirty dry.There is physical strength reinforcing, resisting fatigue, tranquillizing and allaying excitement, protect the liver, increase leukocyte cAMP, strengthen the functions such as immunity and antiallergic action.
Semen Sesami Nigrum: property is put down, sweet in the mouth.Return Liver Channel, kidney channel, large intestine channel.Effect and effect: invigorating the liver and kidney, benefiting essence-blood, intestine moistening are dry.With controlling dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation, deficiency of the liver and kindey, migratory arthralgia, paralysis, married woman's breast less.
Fructus Crataegi cuneatae: slightly warm in nature, sour in the mouth, sweet.Return spleen channel, stomach warp, Liver Channel.Effect and effect: removing food stagnancyization is stagnant, dispelling the stagnated QI dissipating blood stasis.For meat stagnation, children's's infantile dyspepsia, abdominal distention, dysentery, has loose bowels, dysmenorrhea, and postnatal blood stasis is suffered from abdominal pain, hernia, hyperlipidemia.
Auricularia: property is put down, sweet in the mouth.Return lung meridian, spleen channel, large intestine channel, Liver Channel.Effect and effect: benefiting qi and nourishing blood, nourishing the lung to arrest cough, hemostasis, blood pressure lowering, anticancer.Cure mainly Qi and blood deficiency, chronic cough of deficiency lung, spitting of blood, epistaxis, dysentery, bleeding hemorrhoids, woman uterine bleeding, hypertension, retinal hemorrhage, cervical cancer, cancer of vagina, traumatic pain.
Tremella: property is put down, sweet in the mouth.Return lung meridian, stomach warp, kidney channel.Effect and effect: the effects such as the lung moistening and production of body fluid promoting, tonifying-Yin and nourishing-stomach, QI invigorating and blood regulating, benefit marrow heart tonifying, clearing away lung-heat, Ji kidney are dry, looks improving and the skin nourishing.With controlling cough due to lung-heat, dryness of the lung dry cough, chronic cough itching of the throat, the disease such as costalgia and lung abscess, consumptive lung disease, menoxenia, gastritis, constipation and hematochezia hindered by cough with blood-flecked phlegm, chronic cough network.
Herba Selaginellae: property is put down, acrid in the mouth.Return Liver Channel, heart channel.Effect and effect: blood circulation promoting and blood stasis dispelling, hemostasis.For women's amenorrhea, dysmenorrhea, leprosy abdominal mass, gastral cavity abdomen stasis of blood pain, traumatic injury, congestive edema, multiple hemorrhage, burn due to hot liquid or fire.
Semen Juglandis: warm in nature, sweet in the mouth.Return kidney channel, lung meridian, large intestine channel.Effect and effect: temperature compensation lung kidney, asthma-relieving phlegm-reducing, intestine moistening arresting seminal emission.With controlling soreness of the waist and knees, deficiency and coldness is breathed with cough, sexual impotence of passing out semen, constipation.
Semen Allii Tuberosi: warm in nature, acrid in the mouth, sweet.Return kidney channel, Liver Channel.Effect and effect: temperature compensation Liver and kidney, tonifying YANG controlling nocturnal emission with astringent drugs.Treatment seminal emission, soreness of waist and knee joint, enuresis frequent micturition, nebulousurine leukorrhagia.
Semen Brassicae Campestris: property is put down, acrid in the mouth, sweet.Return Liver Channel, large intestine channel.Effect and effect: blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, loosening bowel to relieve constipation.Cure mainly prolonged lochia, abdominal pain due to blood stasis, dysmenorrhea, discharging fresh blood stool, dysentery, Fengshi Guanjie swells and ache, carbuncle erysipelas, acute mastitis, constipation, adhesive ileus.
Flos Rosae Chinensis: warm in nature, sweet in the mouth.Return Liver Channel.Effect and effect: promoting blood flow to regulate menstruation, dispersing the stagnated live-QI to relieve the stagnation of QI.The menoxenia caused with controlling depression of liver-QI, dysmenorrhea, amenorrhea, chest and abdomen swelling and pain, traumatic injury, blood stasis are swollen and ache, swollen ulcer drug and scrofula etc.
The Chinese medicinal capsule scientific formulation for the treatment of endocrine disturbance provided by the invention, prepare simple, evident in efficacy, have no side effect, be easy to carry, taking convenience.In addition, excellent results of the present invention also shows:
1, Chinese medicinal capsule of the present invention adopts common Chinese medicine material as raw material, and mostly be mild in medicine property and thing, with low cost, even if life-time service also can not increase the burden on economy and health to user.
2, the formula of Chinese medicine composition of the present invention meets Chinese medicine " overall conditioning, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs " principle completely, there is blood yiqi, regulating menstruation of reinforcing the kidney, dispersing the stagnated live-QI to relieve the stagnation of QI, tonifying-Yin and nourishing-stomach effect, effectively can treat endocrine disturbance.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat an endocrine disturbance's Chinese medicinal capsule, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 20 parts, Fructus Akebiae 15 parts, 10 parts, Fructus Jujubae, Semen Sesami Nigrum 10 parts, Fructus Crataegi cuneatae 8 parts, 5 parts, Auricularia, 5 parts, Tremella, Herba Selaginellae 5 parts, Semen Juglandis 4 parts, Semen Allii Tuberosi 4 parts, Semen Brassicae Campestris 2 parts, Flos Rosae Chinensis 1 part.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance, step is as follows:
Step one: after Fructus Jujubae (pitted), Semen Sesami Nigrum, Semen Juglandis cleaning are dried, be placed in respectively in the hot pot of 40 DEG C, use slow fire parch, wait to fry to Fructus Jujubae and the micro-yellow of Semen Juglandis crust, Semen Sesami Nigrum has cracker, when having fragrance to overflow, taking-up, is ground into 80 object fine powders;
Step 2: by dry tremella, the dried Auricularia warm water soaking 5 minutes of 30 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, is placed in fill in container that concentration is the white sugar water of 40% and soaks 10 minutes, drain away the water;
Step 3: Herba Leonuri, Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Semen Allii Tuberosi, Semen Brassicae Campestris, Flos Rosae Chinensis are cleaned up, dry, after being crushed to 40 orders, adding raw material weight 2 times of volume fractions is the ethanol of 85%, soak 10min, ultrasonic temperature 40 DEG C, after extracting 20min under ultrasonic power 60W condition, obtain ethanol extract, under 60 DEG C of conditions, be evaporated to the extractum of relative density 1.20;
Step 4: by the Fructus Jujubae of step one, Semen Sesami Nigrum, Semen Juglandis fine powder, the extractum of the Tremella that step 2 obtains, Auricularia and step 3 mixes, and stirs into thick paste, dry, pulverize into 80 object fine powders, incapsulate and obtain capsule finished product after mixing at 50 DEG C.
embodiment 2treat an endocrine disturbance's Chinese medicinal capsule, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 30 parts, Fructus Akebiae 25 parts, 20 parts, Fructus Jujubae, Semen Sesami Nigrum 20 parts, Fructus Crataegi cuneatae 16 parts, 15 parts, Auricularia, 15 parts, Tremella, Herba Selaginellae 15 parts, Semen Juglandis 12 parts, Semen Allii Tuberosi 12 parts, Semen Brassicae Campestris 8 parts, Flos Rosae Chinensis 5 parts.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance, step is as follows:
Step one: after Fructus Jujubae (pitted), Semen Sesami Nigrum, Semen Juglandis cleaning are dried, be placed in respectively in the hot pot of 50 DEG C, use slow fire parch, wait to fry to Fructus Jujubae and the micro-yellow of Semen Juglandis crust, Semen Sesami Nigrum has cracker, when having fragrance to overflow, taking-up, is ground into 80 object fine powders;
Step 2: by dry tremella, the dried Auricularia warm water soaking 15 minutes of 40 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, is placed in fill in container that concentration is the white sugar water of 40% and soaks 10 minutes, drain away the water;
Step 3: Herba Leonuri, Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Semen Allii Tuberosi, Semen Brassicae Campestris, Flos Rosae Chinensis are cleaned up, dry, after being crushed to 40 orders, adding raw material weight 2-6 times volume fraction is the ethanol of 95%, soak 20min, ultrasonic temperature 40 DEG C, after extracting 40min under ultrasonic power 60W condition, obtain ethanol extract, under 60 DEG C of conditions, be evaporated to the extractum of relative density 1.20;
Step 4: by the Fructus Jujubae of step one, Semen Sesami Nigrum, Semen Juglandis fine powder, the extractum of the Tremella that step 2 obtains, Auricularia and step 3 mixes, and stirs into thick paste, dry, pulverize into 120 object fine powders, incapsulate and obtain capsule finished product after mixing at 60 DEG C.
embodiment 3treat an endocrine disturbance's Chinese medicinal capsule, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 23 parts, Fructus Akebiae 18 parts, 14 parts, Fructus Jujubae, Semen Sesami Nigrum 14 parts, Fructus Crataegi cuneatae 10 parts, 8 parts, Auricularia, 8 parts, Tremella, Herba Selaginellae 8 parts, Semen Juglandis 6 parts, Semen Allii Tuberosi 6 parts, Semen Brassicae Campestris 4 parts, Flos Rosae Chinensis 2 parts.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance, step is as follows:
Step one: after Fructus Jujubae (pitted), Semen Sesami Nigrum, Semen Juglandis cleaning are dried, be placed in respectively in the hot pot of 42 DEG C, use slow fire parch, wait to fry to Fructus Jujubae and the micro-yellow of Semen Juglandis crust, Semen Sesami Nigrum has cracker, when having fragrance to overflow, taking-up, is ground into 80 object fine powders;
Step 2: by dry tremella, the dried Auricularia warm water soaking 8 minutes of 33 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, is placed in fill in container that concentration is the white sugar water of 40% and soaks 10 minutes, drain away the water;
Step 3: Herba Leonuri, Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Semen Allii Tuberosi, Semen Brassicae Campestris, Flos Rosae Chinensis are cleaned up, dry, after being crushed to 40 orders, adding raw material weight 3 times of volume fractions is the ethanol of 88%, soak 14min, ultrasonic temperature 40 DEG C, after extracting 25min under ultrasonic power 60W condition, obtain ethanol extract, under 60 DEG C of conditions, be evaporated to the extractum of relative density 1.20;
Step 4: by the Fructus Jujubae of step one, Semen Sesami Nigrum, Semen Juglandis fine powder, the extractum of the Tremella that step 2 obtains, Auricularia and step 3 mixes, and stirs into thick paste, dry, pulverize into 90 object fine powders, incapsulate and obtain capsule finished product after mixing at 53 DEG C.
embodiment 4treat an endocrine disturbance's Chinese medicinal capsule, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 27 parts, Fructus Akebiae 22 parts, 16 parts, Fructus Jujubae, Semen Sesami Nigrum 16 parts, Fructus Crataegi cuneatae 14 parts, 12 parts, Auricularia, 12 parts, Tremella, Herba Selaginellae 12 parts, Semen Juglandis 10 parts, Semen Allii Tuberosi 10 parts, Semen Brassicae Campestris 6 parts, Flos Rosae Chinensis 4 parts.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance, step is as follows:
Step one: after Fructus Jujubae (pitted), Semen Sesami Nigrum, Semen Juglandis cleaning are dried, be placed in respectively in the hot pot of 48 DEG C, use slow fire parch, wait to fry to Fructus Jujubae and the micro-yellow of Semen Juglandis crust, Semen Sesami Nigrum has cracker, when having fragrance to overflow, taking-up, is ground into 80 object fine powders;
Step 2: by dry tremella, the dried Auricularia warm water soaking 12 minutes of 37 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, is placed in fill in container that concentration is the white sugar water of 40% and soaks 10 minutes, drain away the water;
Step 3: Herba Leonuri, Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Semen Allii Tuberosi, Semen Brassicae Campestris, Flos Rosae Chinensis are cleaned up, dry, after being crushed to 40 orders, adding raw material weight 5 times of volume fractions is the ethanol of 92%, soak 16min, ultrasonic temperature 40 DEG C, after extracting 35min under ultrasonic power 60W condition, obtain ethanol extract, under 60 DEG C of conditions, be evaporated to the extractum of relative density 1.20;
Step 4: by the Fructus Jujubae of step one, Semen Sesami Nigrum, Semen Juglandis fine powder, the extractum of the Tremella that step 2 obtains, Auricularia and step 3 mixes, and stirs into thick paste, dry, pulverize into 110 object fine powders, incapsulate and obtain capsule finished product after mixing at 57 DEG C.
embodiment 5treat an endocrine disturbance's Chinese medicinal capsule, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): Herba Leonuri 25 parts, Fructus Akebiae 20 parts, 15 parts, Fructus Jujubae, Semen Sesami Nigrum 15 parts, Fructus Crataegi cuneatae 12 parts, 10 parts, Auricularia, 10 parts, Tremella, Herba Selaginellae 10 parts, Semen Juglandis 8 parts, Semen Allii Tuberosi 8 parts, Semen Brassicae Campestris 5 parts, Flos Rosae Chinensis 3 parts.
The preparation method of the Chinese medicinal capsule of above-mentioned treatment endocrine disturbance, step is as follows:
Step one: after Fructus Jujubae (pitted), Semen Sesami Nigrum, Semen Juglandis cleaning are dried, be placed in respectively in the hot pot of 45 DEG C, use slow fire parch, wait to fry to Fructus Jujubae and the micro-yellow of Semen Juglandis crust, Semen Sesami Nigrum has cracker, when having fragrance to overflow, taking-up, is ground into 80 object fine powders;
Step 2: by dry tremella, the dried Auricularia warm water soaking 10 minutes of 35 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, is placed in fill in container that concentration is the white sugar water of 40% and soaks 10 minutes, drain away the water;
Step 3: Herba Leonuri, Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Semen Allii Tuberosi, Semen Brassicae Campestris, Flos Rosae Chinensis are cleaned up, dry, after being crushed to 40 orders, adding raw material weight 4 times of volume fractions is the ethanol of 90%, soak 15min, ultrasonic temperature 40 DEG C, after extracting 30min under ultrasonic power 60W condition, obtain ethanol extract, under 60 DEG C of conditions, be evaporated to the extractum of relative density 1.20;
Step 4: by the Fructus Jujubae of step one, Semen Sesami Nigrum, Semen Juglandis fine powder, the extractum of the Tremella that step 2 obtains, Auricularia and step 3 mixes, and stirs into thick paste, dry, pulverize into 100 object fine powders, incapsulate and obtain capsule finished product after mixing at 55 DEG C.
experimental example:the II clinical trial phase of this medicine, according to State Food and Drug Administration's Clinical Researches of New Drugs official written reply requirement, according to " Good Clinical " and " technical requirement of study of tcm new drug ", in conjunction with clinical experience and relevant document, formulate clinical trial protocol, take NO. 5 People's Hospital, Jinan City as research unit, II clinical trial phase is carried out to the Chinese medicinal capsule of the treatment endocrine disturbance in the embodiment of the present invention 5, observe case 200 example altogether, wherein treatment group 100 example, matched group 100 example, result shows: the Chinese medicinal capsule that the present invention treats endocrine disturbance has blood yiqi, to reinforce the kidney regulating menstruation, dispersing the stagnated live-QI to relieve the stagnation of QI, effect of tonifying-Yin and nourishing-stomach, total effective rate is 98%, cure rate is 92%, and the effective percentage of western medicine group only has 78%, Chinese medicinal capsule of the present invention is compared with western medicine group, obviously have with low cost, onset is rapid, treating both the principal and secondary aspects of a disease, the feature had no side effect, for treatment, endocrine disturbance has good effect.
model case:
Case 1: normal XX, female, 32 years old, height: 1.59 meters, body weight: 48 kilograms.Patient's readme: marry 4 years, infertile, menarche 14 years old, menstrual cycle 36-40 days, menstrual period 5-7 days, through amount in, have clot, premenstrual often have lower abdomen bearing down, through period coldness of the body with chills.Lower abdomen drops, lumbago, arthritis and cool.Do gonadal hormone six inspection: lactotropin and androgen higher, ultrasound diagnosis prompting follicular dysplasia (slowly) is done in menstruation 13-17 days, be diagnosed as the endocrine disturbance caused by asthenia of both the spleen and kidney, insufficiency of vital energy and blood, take Chinese medicinal capsule of the present invention 20 days, abdominal pain in menstruation alleviates, and clot disappears, after continuing to take 1 month, malaise symptoms disappears completely, pays a return visit after 1 year, conceived.
Case 2: horse XX, female, 28 years old, tubal patency, menstrual cycle was irregular, and 5 days menstrual periods, color is red, without clot, drowsiness, constipation, and urine is turned to be yellow, and premenstrual distending pain of the breast, extremity fine hair is dense, retracted nipple, and red tongue tongue white edge has indentation, and deep pulse is fine and smooth.B ultrasonic diagnostic impression: the little follicular development of right ovary, left folliculus ovarii Luteinized.Be diagnosed as endocrine disturbance, take Chinese medicinal capsule of the present invention 10 days, the suitable symptoms such as drowsiness, constipation, urine alleviate, and after taking 1 month, next time, the eumenorrhea, continued to take after treatment in 1 month, recovery from illness.
Case 3: yellow XX, man, 21 years old, facial small pox multiple half a year, energy was not concentrated, hypomnesis, sleep reduce, easily tired; Ability to work declines; Dizzy nervous, cold extremities; Muscle minimizing, lipotrophy, psychological need go down.Be diagnosed as: endocrine disturbance.Take Chinese medicinal capsule first quarter moon of the present invention, facial small pox is clearly better, and sleep is improved; After continuing to take first quarter moon, facial small pox and other symptom disappear completely, cure.
Claims (10)
1. treat an endocrine disturbance's Chinese medicinal capsule, it is characterized in that: take off the raw material of Chinese medicine stating weight proportion and be prepared from: Herba Leonuri 20-30 part, Fructus Akebiae 15-25 part, Fructus Jujubae 10-20 part, Semen Sesami Nigrum 10-20 part, Fructus Crataegi cuneatae 8-16 part, Auricularia 5-15 part, Tremella 5-15 part, Herba Selaginellae 5-15 part, Semen Juglandis 4-12 part, Semen Allii Tuberosi 4-12 part, Semen Brassicae Campestris 2-8 part, Flos Rosae Chinensis 1-5 part.
2. the Chinese medicinal capsule for the treatment of endocrine disturbance according to claim 1, is characterized in that: take off the raw material of Chinese medicine stating weight proportion and be prepared from: Herba Leonuri 23-27 part, Fructus Akebiae 18-22 part, Fructus Jujubae 14-16 part, Semen Sesami Nigrum 14-16 part, Fructus Crataegi cuneatae 10-14 part, Auricularia 8-12 part, Tremella 8-12 part, Herba Selaginellae 8-12 part, Semen Juglandis 6-10 part, Semen Allii Tuberosi 6-10 part, Semen Brassicae Campestris 4-6 part, Flos Rosae Chinensis 2-4 part.
3. the Chinese medicinal capsule for the treatment of endocrine disturbance according to claim 1, is characterized in that: take off the raw material of Chinese medicine stating weight proportion and be prepared from: Herba Leonuri 25 parts, Fructus Akebiae 20 parts, 15 parts, Fructus Jujubae, Semen Sesami Nigrum 15 parts, Fructus Crataegi cuneatae 12 parts, 10 parts, Auricularia, 10 parts, Tremella, Herba Selaginellae 10 parts, Semen Juglandis 8 parts, Semen Allii Tuberosi 8 parts, Semen Brassicae Campestris 5 parts, Flos Rosae Chinensis 3 parts.
4. a preparation method for the Chinese medicinal capsule of the treatment endocrine disturbance according to any one of claim 1-3, is characterized in that: step is as follows:
Step one: after Fructus Jujubae (pitted), Semen Sesami Nigrum, Semen Juglandis cleaning are dried, be placed in respectively in the hot pot of 40-50 DEG C, use slow fire parch, wait to fry to Fructus Jujubae and the micro-yellow of Semen Juglandis crust, Semen Sesami Nigrum has cracker, when having fragrance to overflow, take out, be ground into 80 object fine powders;
Step 2: by dry tremella, the dried Auricularia warm water soaking 5-15 minute of 30-40 DEG C, go root clear water to rinse well, be cut into the block of small rice grain size, be placed in fill concentration be the white sugar water of 40% container in soak 10 minutes, drain away the water;
Step 3: Herba Leonuri, Fructus Akebiae, Fructus Crataegi cuneatae, Herba Selaginellae, Semen Allii Tuberosi, Semen Brassicae Campestris, Flos Rosae Chinensis are cleaned up, dry, after being crushed to 40 orders, adding raw material weight 2-6 times volume fraction is the ethanol of 85%-95%, soak 10-20min, ultrasonic temperature 40 DEG C, after extracting 20-40min under ultrasonic power 60W condition, obtain ethanol extract, under 60 DEG C of conditions, be evaporated to the extractum of relative density 1.20;
Step 4: by the Fructus Jujubae of step one, Semen Sesami Nigrum, Semen Juglandis fine powder, the extractum of the Tremella that step 2 obtains, Auricularia and step 3 mixes, and stirs into thick paste, dry at 50-60 DEG C, be ground into 80-120 object fine powder, incapsulate after mixing and obtain capsule finished product.
5. a kind of preparation method for the treatment of the Chinese medicinal capsule of endocrine disturbance according to claim 4, is characterized in that: step 2 is by the warm water soaking 8-12 minute of dry tremella, dried Auricularia 33-37 DEG C.
6. a kind of preparation method for the treatment of the Chinese medicinal capsule of endocrine disturbance according to claim 5, is characterized in that: step 2 is by dry tremella, the dried Auricularia warm water soaking 10 minutes of 35 DEG C.
7. a kind of preparation method for the treatment of the Chinese medicinal capsule of endocrine disturbance according to claim 4, it is characterized in that: it is the ethanol of 88%-92% that step 3 adds raw material weight 3-5 times volume fraction, soak 14-16min, ultrasonic temperature 40 DEG C, after extracting 25-35min under ultrasonic power 60W condition, obtain ethanol extract.
8. a kind of preparation method for the treatment of the Chinese medicinal capsule of endocrine disturbance according to claim 7, it is characterized in that: it is the ethanol of 90% that step 3 adds raw material weight 4 times of volume fractions, soak 15min, ultrasonic temperature 40 DEG C, after extracting 30min under ultrasonic power 60W condition, obtain ethanol extract.
9. a kind of preparation method for the treatment of the Chinese medicinal capsule of endocrine disturbance according to claim 4, is characterized in that: step 4 dry, pulverize into 90-110 object fine powder at 53-57 DEG C.
10. a kind of preparation method for the treatment of the Chinese medicinal capsule of endocrine disturbance according to claim 9, is characterized in that: step 4 dry, pulverize into 100 object fine powders at 55 DEG C.
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| CN105995279A (en) * | 2016-05-28 | 2016-10-12 | 孙明香 | Health beverage for regulating irregular menstruation of female and preparation method of health beverage |
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| CN104524440A (en) * | 2014-12-16 | 2015-04-22 | 唐珍丽 | Pill for conditioning female endocrine disorder and preparation method of pill |
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