CN109432240A - A kind of bamboo rat oil antipruritic powder poison cream and preparation method thereof - Google Patents
A kind of bamboo rat oil antipruritic powder poison cream and preparation method thereof Download PDFInfo
- Publication number
- CN109432240A CN109432240A CN201811545615.7A CN201811545615A CN109432240A CN 109432240 A CN109432240 A CN 109432240A CN 201811545615 A CN201811545615 A CN 201811545615A CN 109432240 A CN109432240 A CN 109432240A
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- bamboo rat
- antipruritic
- rat oil
- cream
- oil
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Abstract
本发明公开一种竹鼠油止痒散毒膏及其制备方法，属于中医药技术领域。该竹鼠油止痒散毒膏包括竹鼠油、至少一种止痒散毒中草药和至少一种稳定剂剂。其制备方法是止痒散毒中草药经过两次煎煮后，混合煎液，再加入竹鼠油、稳定剂混合后，充分乳化即得。本发明配方合理，制备方法简单，安全无毒副作用，无药物残留，无耐药性，生物利用度高，对于镇痛、消肿、止痒、蚊虫毒蜂叮咬效果显著。The invention discloses a bamboo rat oil anti-itching poisoning paste and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine. The bamboo rat oil anti-itching poisoning paste comprises bamboo rat oil, at least one anti-itching poisoning Chinese herbal medicine and at least one stabilizer. The preparation method is that the itch-relieving Chinese herbal medicine is decocted after being boiled twice, and then mixed with bamboo rat oil and stabilizer, and fully emulsified. The invention has reasonable formula, simple preparation method, safety, no toxic and side effects, no drug residue, no drug resistance, high bioavailability, and remarkable effect on analgesia, swelling, itching and mosquito biting.
Description
Technical field
The present invention relates to technical field of Chinese medicine, and in particular to a kind of bamboo rat oil antipruritic powder poison cream and preparation method thereof.
Background technique
Present people is compeled by life, and stress is generally bigger than normal, meets the eye on every side clamour, congestion and Lin Lin along with city
Total wink, as long as therefore the available free time, all want after leisurely idyllic life, but mosquito, poisonous wasp affect people
Enjoy the mood of " picking chrysanthemum by the east fence down, carefree and leisurely to see South Mountain ".
Mosquito is ubiquitous in nature, it both can directly bite skin and cause insect bite dermatitis, can also pass through it
Excrement, saliva etc. cause scytitis, are summer dermatology common disease diseases, the place of biting occur papule, wheal, edematous erythema,
Blister, papulo-vesicle, petechia ecchymosis etc., with it is different degrees of itch, tingling sensation, wherein most commonly seen with pruitus.Bee, which bites, is
Refer to and stabbed caused by skin as the telson of the bees class such as honeybee, wasp, hornet, scoliid tail portion, after stinging, the toxin in poison gland is logical
The skin of telson injection people is crossed, part has apparent cusalgia and itch immediately, there is small blutpunkte at sting, and it is red and swollen quickly, even
It blisters.
Chinese herbal medicine is China's tradition the most and naturally occurring medicinal material, and source resource is extremely abundant, price is relatively low
It is honest and clean, there is antibacterial, anti-inflammatory, removing toxic substances, detumescence, antipruritic and analgesic effect.The method five that processing mosquito, poisonous wasp are bitten at present spends eight
Door, has plenty of and is cleaned a wound with warm water, suds, salt water, has plenty of and smears ten thousand single caul-fats, safflower oil, cooling ointment, green medicine
Cream etc., but these methods, all can only be it is interim it is auxiliary rescue measure, none complete treatment method well, to make very much
People will restrain oneself 6-7 days pains and discomfort after being bitten by hornet and honeybee, or thousands of first high costs is spent to rescue to hospital
It controls.Therefore, developing effect, good, quick, without side-effects product is still the expectation of people, and the treatment standardized in time can
To avoid or reduce skin damage.
Summary of the invention
Present invention aim to address problems of the prior art, provide a kind of formula rationally, curative effect is obvious, preparation
Method is simply and without side-effects, and can effectively treat mosquito and Chinese herbal and crude drugs preparations that poisonous wasp is bitten.
Raw material of the invention is all from Chinese herbal medicine, and science is configured to a kind of Chinese materia medica preparation treating mosquito bite and insect bite bee and biting, this
Chinese herbal and crude drugs preparations have antibacterial, anti-inflammatory, purging intense heat, removing toxic substances, detumescence, antipruritic and analgesia and other effects, are suitable for various mosquitoes and poisonous wasp
The effect for the treatment of of dermatitis caused by biting, has no toxic side effect, and reaches quickly easing pain, antipruritic, detoxification and detumescence.To realize this hair
Improving eyesight, used technical solution is as follows:
A kind of bamboo rat oil antipruritic powder poison cream, including following raw material:
1) bamboo rat oil；
2) at least one antipruritic powder poison Chinese herbal medicine；
3) at least one stabilizer.
Preferably, the antipruritic powder poison Chinese herbal medicine is cortex dictamni, Sculellaria barbata, peppermint, Siberian cocklebur grass, cicada slough, radix paeoniae rubra, prevents
Wind, kuh-seng, radices trichosanthis, semiaquilegia adoxoides, five color flower, Prunella vulgaris, wild chrysanthemum, branch and viola mandshurica it is one or more.
Preferably, the stabilizer is Glycerin, mixed triester with caprylic acid capric acid.
Preferably, the bamboo rat oil accounts for the mass percent of all raw materials not less than 20%.
Preferably, the bamboo rat oil accounts for the mass percent of all raw materials not less than 30%.
Preferably, the temperature agent accounts for the mass percent of all raw materials not less than 1%.
The present invention also provides a kind of preparation methods of bamboo rat oil antipruritic powder poison cream as previously discussed, comprising the following steps:
(1) each raw material is weighed；
(2) antipruritic powder poison Chinese herbal medicine is put into casserole, drinking water is added, after impregnating 20-30 minutes, added water and do not cross drug, it will
Casserole is placed on stove fire and decocts, and after boiling 40-50 minutes, medical fluid is poured out, and obtains first time medical fluid；
(3) warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, it is mixed with first time medical fluid
It closes, after natural cooling, after bamboo rat oil and stabilizer mixing is added, is boiled into paste, as a kind of Chinese medicine group agent bamboo rat cream.
Further, the present invention also provides a kind of bamboo rat oil antipruritic powder poison cream a kind of as previously discussed treats mosquito in preparation
It is applied in the drug that worm, poisonous wasp etc. swell and ache caused by biting.
(1) bamboo rat oil.Chinese medicine name, this product are Rodentia Rhizomyidae hoarybamboo rat, are inhabited under Chinese silvergrass clump or in bamboo grove.
It is food with bamboo shoots, Chinese silvergrass.Fat claims bamboo rat oil, can do medicine for external application.Scald, burn, mosquito or poisonous insect can be treated or poisonous insect bites
The caused diseases such as pain of itching are powerful to choose foreign matter, removing toxic substances, removing itching and pain of skin after smearing.It is used as medicine with fat.Major function solution
Malicious apocenosis, myogenic pain relieving.
(2) cortex dictamni, alias dittany bark, stereotyped writing ox, seguin argyreia herb, sheep fresh grass are Rutaceae herbaceos perennial shaggy-fruited dittany
With the root skin of Dictamnus angustifolius.Main product is in Liaoning, Hebei, Sichuan, Jiangsu and other places.Spring, two season of autumn excavate root, remove silt and thick
Skin strips root skin, is sliced, dry.It is raw to use.With the effect of heat-clearing and damp-drying drug, wind-dispelling is detoxified.Modern study, the volatilization of cortex dictamni
Oil has antitumaous effect in vitro.
(3) Sculellaria barbata is horse lamiaceae labiatae scutellaria herbaceos perennial.Sun plant plant height is grown thickly close up to 55 centimetres
Collection, Hua Fan is gorgeous, and the florescence is again long, is excellent with spending, also suitable flower bed edge and the plant of flower border for decorating meadow, hillside fields and roadside,
Potting is small and exquisite, can be displayed in balcony, windowsill, corridor, in front of the door, a variety of places such as pool side and garden it is ornamental.All herbal medicine, tool
There are the functions such as clearing heat and detoxicating, promoting blood circulation, swelling and pain relieving, anticancer.It is cold in nature sour, herb containing multivitamin, microelement and
The ingredients such as amino acid.There is the effect of removing pattogenic heat from the blood and toxic material from the body, removing blood stasis and acesodyne, detumescence and clearing heat and promoting diuresis.
(4) peppermint is Lamiaceae plant, that is, belongs to other drying herbs.It is born in by hill wetland river, rhizome grows wild ground more
Under, 2100 meters of height above sea levels are born in, but can also grow on 3500 meters of height above sea level more, are a kind of fragrance work for having extraordinary economic value
Object.Complete stool green gas fragrance.Leaf spends small lavender, lip shape, the granule fruit of Hua Houjie dark violet brown to life.Peppermint is that China is common
One of Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls the diseases such as influenza, headache, hot eyes, body heat, throat, gum swelling and pain.
External application can control neuralgia, pruitus, fash and eczema etc..
(5) Siberian cocklebur grass, other name Xi ear is real, ox louse, son of getting into bed recklessly, grey youth's kind, cotton mantis, grey son, Hu Cangzi, hungry louse,
Grey stalk, Siberian cocklebur puncture vine, grey prodigal, stout pale, wild eggplant, thorn, Indian Skullcap Herb, viscous certain herbaceous plants with big flowers.Fruit is sweating, diuresis, solution
Heat, medicine for dispelling toxin.There are antispastic, analgesic activity.Control myoneural paralysis, arthralgia, the diseases such as oedema.Stem, leaf mash painting scabies, wet
Disease, insect bite.
(6) cicada slough, holotype is hollow like cicada, slightly bent, surface yellowish-brown, translucent, glossy.There is Filamentous touching on head
Angle 1 is right, has broken more and has fallen, and compound eye is prominent, and neck apex is prominent, and tone is flourishing, and upper lip width is short, and lower lip is extended into tubulose.Chest back
Face is in cross sliver, and breach inward curl, back both sides has winglet 2 right；The outside of belly has 3 pairs of foot, by yellowish-brown fine, soft fur.Abdomen
Blunt circle, totally 9 section.Body is light, hollow, frangible.It is odorless, it is lightly seasoned.Function: dispelling wind-heat, promoting eruption relieving sore-throat, removing nebula for improving eyesight, expelling wind and relieving convulsion.
(7) radix paeoniae rubra is the dry root of ranunculaceae plant radix paeoniae rubra or river radix paeoniae rubra.Spring, two season of autumn excavation, remove rhizome, fibrous root and
Silt, this product is cylindrical, slightly bent, long 5~40cm, 0.5~3cm of diameter.Surface sepia, it is coarse, there are longitudinal furrow and wrinkle,
And having the hole skin of mark of fibrous root and lateral projection, some crusts are easy to fall off.Matter is hard and crisp, frangibility, section white powder or pink,
Skin zone is narrow, and the radial texture of woody part is obvious, and some has crack.Gas micro-perfume, it is mildly bitter flavor, sour and astringent., dry.Hardship, it is slightly cold.Return liver warp.
There is the effect of clearing heat and cooling blood, removing blood stasis and acesodyne, promoting blood circulation.
(8) radix saposhnikoviae is umbelliferae.It is born in grassland, dry hillside.Perennial herb.Stem Dan Sheng, dichotomous branch.Base is raw
2~3 times pinnation of leaf, final sliver lanceolar, the long 2~6.5cm of petiole；Acrogen simplifies, tool extension leaf sheath.Multiple umbrella shape flower
Sequence；Without phyllary, rare 1；Umbrella 5~9；Involucel piece 4~5；Bennet 4~9；Flower yellow.Diachenium square round shape width egg shape,
Flat, incline has wing；8~September of florescence, 9~October of fruiting period；Root cylinder or conico-acuminate, long 15~30cm, diameter 0.5~
2cm.It expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion and the effect of relieving convulsion, is used for cold headache, rheumatic arthralgia, rubella itch and tetanus.
(9) wild chrysanthemum.Shape for composite family herbaceos perennial, wild chrysanthemum capitulum is similar to chrysanthemum, is in class ball
Shape, 0.3~1cm of diameter, brown color.Involucre is made of 4~5 layers of bract.Ligulate flower one is taken turns, yellow, shrinkage curling；Tubular flower is more
Number, buff.Body is light.Property bitter, acrid flavour, it is slightly cold.It is wild in the wildly band such as patana, Tian Bian, roadside.With color Huang without stalk,
Completely, toil, the non-standard-sized sheet person of flower are preferred.Wild chrysanthemum cold nature has dispelling wind and heat from the body, subdhing swelling and detoxicating.Leaf, flower and the herb of mother chrysanthemum enter
Medicine.Bitter, pungent, cool, clearing heat and detoxicating, wind-dispelling heat-dissipating dissipate the stasis of blood, improving eyesight, blood pressure lowering.Hypertension, hepatitis, dysentery, carbuncle furuncle is treated to treat
Sore has positive effect.
(10) branch.Also referred to as cape jasmine, Chinese medicine name, the major functions: Vexed, irascibility hot eyes, headache, damp and hot yellow infantile malnutrition due to digestive disturbances or intestinalparasites, stranguria,
Bloody flux hematuria, sore swollen toxin, sprains swelling and pain at aphthae.
(11) radices trichosanthis.Chinese medicine name is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and histone amino acids contains smallpox
Amyloid proteins is made of 19 kinds of amino acid, by the alkaline protein for the single polypeptide chain that 234 amino acid residues form.Also contain
There are 13 kinds of amino acid, such as citrulling, arginine, glutamic acid, aspartic acid.For clearing heat-fire class drug, specific effect is
Clearing heat-fire promotes the production of body fluid to quench thirst, apocenosis detumescence.Can clearing heat-fire and detoxify and detumescence and apocenosis is to treat sore, at the beginning of controlling sore
It rises, excessive noxious heat can not make to dissipate at purulence person, and winner can burst sore apocenosis purulence.
(12) kuh-seng, Chinese medicine name.For the dry root of leguminous plant kuh-seng, spring, the excavation of two season of autumn, root head and ramuscule are removed
Root, cleaning, drying, or fresh slices are taken advantage of, it is dry.It is bitter, trembles with fear.There are heat-clearing and damp-drying drug, desinsection, the function of diuresis.For hot dysentery, hematochezia,
Jaundice urodialysis, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, castor control trichomonas vaginitis outside.
(13) semiaquilegia adoxoides is the perennial herblet of Ranunculaceae Semiaquilegia, and root tuber is up to 2 centimetres, crust brownish black.Semiaquilegia adoxoides
Root tuber is used as medicine, sweet in flavor, and slight bitter, micro-pungent have the effects of clearing heat and detoxicating, swelling and pain relieving, diuresis, controls mazoitis, tonsillitis, carbuncle
The diseases such as swollen, scrofula, difficult urination.
(14) five color flower, alias five color flower, lantana, blusher flower, are the flower of plant lantana, whole year blooms.It is frequently grown
In 80-1500 meters of height above sea level of seashore sandy beach and open space.Root, leaf, flower are made medicinal, have clearing heat and detoxicating, eliminating stagnation to stop pain, wind-dispelling to stop
The benefits of itching.
(15) viola mandshurica, alias open country violet, light valve violet etc., perennial herb belong to Parietales, and Violaceae is for many years
Sward sheet, taste bitter, acrid, cold, converge to heart and liver channels.Herb hyoscine, clearing heat and detoxicating, the cool blood detumescence of energy, cures mainly furunculosis, carbuncle swells, scrofula
Scrofula, jaundice, dysentery, diarrhea, hot eyes, sore throat, venomous snake bite.
(16) Prunella vulgaris is herbaceos perennial, creeping rootstock, raw fibrous root on section.Stem is up to 30 centimetres, more points of base portion
Branch, lilac are grown in the wet thick grass of gully meadow bog or riverbank both sides, wasteland, roadside.Relieve inflammation or internal heat improving eyesight the effect of, mesh can be controlled
Red swelling and pain, headache etc..This product can heat-clearing remove irascibility and mass dissipating and swelling eliminating.
(17) Glycerin, mixed triester with caprylic acid capric acid.It is using the greases such as coconut oil or palm-kernel oil, litsea citrate oil as raw material, is hydrolyzed, divided
It evaporates, cut, obtain octanoic acid, capric acid and glycerine esterification, then colourless, tasteless transparency liquid is made in depickling, dehydration, decoloration,
Viscosity is the half of general vegetable oil.Freezing point is low, and oxidation stability is good.It is given birth to various solvents, grease, some oxidants, dimension
Element has good intersolubility.Its emulsibility, dissolubility, extensibility and lubricity are better than common grease, as there is special function
Diluent, emulsion stabilizer, solubilizer and the essence oil base of effect use, and are also used as the defoaming agent and preservative of food production.It produces
It is product colorless and odorless, transparent limpid, it has good stability, shelf-stable；It is widely used in food, cosmetics and pharmacy industry.
Beneficial effects of the present invention:
1, raw material of the present invention is the Chinese herbal medicine of " integration of drinking and medicinal herbs ", safe without toxic side effect, pollution-free, drug residue free, without drug resistance
Property, bioavilability is high, significant in efficacy.It is relatively simple to overcome bite by mosquitos class itching-relieving cream effect currently on the market, is mostly
Mosquito stings product, various for outdoor caste, all very big, the of the invention bamboo rat oil antipruritic powder of the risk bitten by mosquito, worm, bee
Malicious cream treat antipruritic, and significant effect for biting for the various insects such as a variety of mosquitos, worm, bee.
2, rationally, preparation method is simple, and product quality is more stable for formula, has anti-inflammatory, purging intense heat, removing toxic substances, detumescence, antipruritic
Skin can be sterilized, anti-inflammatory with analgesic function by the effect of Chinese herbal medicine, promote local microcirculation, exclude poison
Element, and it is nontoxic, it does not stimulate.
3, clinical application proves, has bitten significant curative effect to mosquito and poisonous wasp etc., and without side-effects, has been effectively ensured
The health of people.
Specific embodiment
The present invention program is described in further detail below with reference to embodiment, following the description is merely to explain this hair
It is bright, its content is not defined.Experimental method used in following embodiments is conventional side unless otherwise specified
Method, material as used in the following examples, reagent etc., is commercially available unless otherwise specified.
Embodiment 1 prepares a kind of a kind of bamboo rat oil antipruritic powder poison cream of bamboo rat oil antipruritic powder poison cream, and preparation includes following step
It is rapid:
(1) raw material is weighed according to following parts by weight: bamboo rat oil 50mL, cortex dictamni 5g, Sculellaria barbata 5g, peppermint 5g, Siberian cocklebur grass 5g, cicada
Slough off 5g, radix paeoniae rubra 5g, radix saposhnikoviae 5g, kuh-seng 5g, radices trichosanthis 5g, semiaquilegia adoxoides 10g, five color flower 10g, Prunella vulgaris 10g, wild chrysanthemum 10g, branch
10g, 10g parts of viola mandshurica and Glycerin, mixed triester with caprylic acid capric acid 2mL.
(2) by cortex dictamni, Sculellaria barbata, peppermint, Siberian cocklebur grass, cicada slough, radix paeoniae rubra, radix saposhnikoviae, kuh-seng, radices trichosanthis, semiaquilegia adoxoides, the five colors
Flower, Prunella vulgaris, wild chrysanthemum, branch and viola mandshurica are put into casserole, and drinking water is added, and after impregnating 20-30 minutes, add water no mistake
Casserole is placed on stove fire and decocts by drug, and after boiling 40-50 minutes, medical fluid is poured out, and obtains first time medical fluid；
(3) warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, it is mixed with first time medical fluid
Synthetic drug water decoction.Bamboo rat oil and Glycerin, mixed triester with caprylic acid capric acid raw material are added, paste is boiled into, is cooled to room temperature discharging, dress is clean
Container.
Embodiment 2
A kind of bamboo rat oil antipruritic powder poison cream, preparation the following steps are included:
(1) raw material is weighed according to following parts by weight: bamboo rat oil 40mL, cortex dictamni 10g, Sculellaria barbata 5g, peppermint 10g, Siberian cocklebur grass
10g, cicada slough 5g, radix paeoniae rubra 10g, radix saposhnikoviae 10g, kuh-seng 10g, radices trichosanthis 10g, semiaquilegia adoxoides 10g, five color flower 10g, Prunella vulgaris 10g, mother chrysanthemum
Flower 10g, branch 10g, 10g parts of viola mandshurica and Glycerin, mixed triester with caprylic acid capric acid 2mL.
(2) by cortex dictamni, Sculellaria barbata, peppermint, Siberian cocklebur grass, cicada slough, radix paeoniae rubra, radix saposhnikoviae, kuh-seng, radices trichosanthis, semiaquilegia adoxoides, the five colors
Flower, Prunella vulgaris, wild chrysanthemum, branch and viola mandshurica are put into casserole, and drinking water is added, and after impregnating 20-30 minutes, add water no mistake
Casserole is placed on stove fire and decocts by drug, and after boiling 40-50 minutes, medical fluid is poured out, and obtains first time medical fluid；
(3) warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, it is mixed with first time medical fluid
Synthetic drug water decoction.Bamboo rat oil and Glycerin, mixed triester with caprylic acid capric acid raw material are added, paste is boiled into, is cooled to room temperature discharging, dress is clean
Container.
Embodiment 3
A kind of bamboo rat oil antipruritic powder poison cream, preparation the following steps are included:
(1) raw material is weighed according to following parts by weight: bamboo rat oil 40mL, cortex dictamni 8g, Sculellaria barbata 8g, peppermint 8g, Siberian cocklebur grass 8g, cicada
Slough off 8g, radix paeoniae rubra 8g, radix saposhnikoviae 8g, kuh-seng 8g, radices trichosanthis 8g, semiaquilegia adoxoides 10g, five color flower 10g, Prunella vulgaris 10g, wild chrysanthemum 10g, branch
10g, 10g parts of viola mandshurica and Glycerin, mixed triester with caprylic acid capric acid 2mL.
(2) by cortex dictamni, Sculellaria barbata, peppermint, Siberian cocklebur grass, cicada slough, radix paeoniae rubra, radix saposhnikoviae, kuh-seng, radices trichosanthis, semiaquilegia adoxoides, the five colors
Flower, Prunella vulgaris, wild chrysanthemum, branch and viola mandshurica are put into casserole, and drinking water is added, and after impregnating 20-30 minutes, add water no mistake
Casserole is placed on stove fire and decocts by drug, and after boiling 40-50 minutes, medical fluid is poured out, and obtains first time medical fluid；
(3) warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, it is mixed with first time medical fluid
Synthetic drug water decoction.Bamboo rat oil and Glycerin, mixed triester with caprylic acid capric acid raw material are added, paste is boiled into, is cooled to room temperature discharging, dress is clean
Container.
Application example:, will be real for the drug effect and safety index problem for further investigating bamboo rat oil antipruritic powder poison cream of the present invention
Apply example 1 preparation bamboo rat oil antipruritic powder poison cream carry out mouse experiment, respectively from skin sensibiligen, anti-inflammatory effects, analgesic effect,
The indexs such as antipruritic effect and clinical effectiveness are examined, as a result such as embodiment 4 to embodiment 8.
Embodiment 4
A kind of bamboo rat oil antipruritic powder poison cream prepared by embodiment 1 tests skin sensibiligen, as follows using step and effect:
(1) Kunming mouse 20 are taken, half male and half female, every weight about 20g is randomly divided into 2 groups.
(2) each back of mice two sides skin depilatory about 10cm2(account for about entire skin area 15%), one group of mouse are made
Skin injury group, another group is non-damaged group.One layer of ointment is applied in hair removal section, is observed continuously 7 days, and weigh.
(3) result.It is observed that two groups of mouse do not reveal any abnormalities reaction, skin, stool, breathing, four limbs activity,
Behavior etc. does not reveal any abnormalities phenomenon；Weight is in rising trend, does not decline.The plaster is to mouse external application without any
Acute toxic reaction occurs.
Embodiment 5
A kind of bamboo rat oil antipruritic powder poison cream prepared by embodiment 1 is as follows using step and effect to anti-inflammatory effect test:
(1) Kunming mouse 20 are taken, half male and half female is randomly divided into 2 groups.
(2) the hard of hearing portion's skin depilatory about 4cm of each mouse2, about 37 DEG C of warm medical fluid 0.5ml are applied in hair removal section, 2 times a day, even
It is 3 days continuous.30min after the last administration is uniformly applied to the left auricular concha two of mouse with dimethylbenzene 0.1ml and then causes inflammation, auris dextra do not apply as pair
According to.30 minutes execution animals after cause is scorching, mouse ears homalographic auricle is cut off, weigh immediately with diameter 6mm punch.
(3) two ear weight differences are swelling, compared with physiological saline group.The result shows that a kind of bamboo rat oil antipruritic powder poison cream energy
It is obvious to inhibit auricular concha acute inflammation (being shown in Table 1) caused by dimethylbenzene.
Table 1. is to mouse inflammatory effect test result
| Group | n | Swelling (mg) | Inhibiting rate |
| Physiological saline | 10 | 15.3±3.3 | / |
| Bamboo rat oil antipruritic powder poison cream | 10 | 5.8±3.9 | 62.1% |
Embodiment 6
A kind of bamboo rat oil antipruritic powder poison cream prepared by embodiment 1 tests analgesic effect, as follows using step and effect:
(1) mouse is chosen.Take Kunming kind female mice 30, every weight about 20g；Adjust ultra thermostat keep temperature constant
55 ± 0.5 DEG C, mouse is placed in porcelain jar, tank mouth lid transparency cover, licks metapedes as pain reaction index to observe mouse, record
The aitiogenic time is normal pain threshold (about 25 DEG C of room temperature).Mouse 20 of the pain threshold within 10-30s is selected to be only used as trying
Mouse is tested, is randomly divided into 2 groups.
(2) pain threshold measures.Test is divided into 2 groups, and one group is bamboo rat oil antipruritic powder poison cream group, and another group is blank control.
The double metapedes of bamboo rat oil antipruritic powder poison cream group mouse are applied medicinal lotion or ointment cream 2 times, every time after the absorption of applied medical fluid, then are applied next time, are then put
Enter in porcelain jar；Blank control group applies 0.4ml physiological saline.It is primary respectively to survey the small white mouse threshold of pain by 15min, 30min, 60min after medication,
If be put into after medication in porcelain jar 60 seconds it is still reactionless, i.e., small white mouse is taken out, so as not to the time it is too long foot is scalded, the threshold of pain
It can be calculated by 60 seconds.
(3) result.Compared according to measured value and changed between the change of administration front and back and group, and is averaged after calculating threshold of pain increase rate (%)=medicine
Average value × 100% (the results are shown in Table 2) before average value/medicine before pain threshold-medicine.The result shows that bamboo rat oil antipruritic powder poison cream can be big
Amplitude improves mouse pain threshold, there is good analgesic effect.
Table 2. influences test result to mouse pain threshold
Embodiment 7
A kind of bamboo rat oil antipruritic powder poison cream prepared by embodiment 1 tests antipruritic effect, as follows using step and effect:
(1) cavy is chosen.Cavy 20 are chosen, is lost hair or feathers to instep behind the cavy right side, area is about 1cm2, it is randomly divided into 2 groups, every group
10.
(2) antipruritic threshold value determination.Blank control group cavy smears 50 μ L physiological saline；Positive controls uniformly smear 50 μ L
Bamboo rat oil antipruritic powder poison cream.After smearing cavy is right daily 2 times, delivery time 30min, successive administration 6d at instep depilation.
After last dose 30min, respectively at instep depilation behind the emery cloth scratch cavy right side, scratch degree is not hurt true with damaging epidermis
Skin, slight oozing of blood are degree, and area is about 1cm2.0.01% histamine phosphate, 50 μ L is dripped in the surface of a wound, it is hereafter incremented by successively every 3min
0.01% concentration is 50 μ L every time, until cavy later licks right metapedes.When occurring later licking metapedes with cavy to
The histamine phosphate total amount given is itch-threshold, records and compare the itch-threshold of each group.
(3) result.Compared according to measured value and changed between the change of administration front and back and group, and put down after calculating itch-threshold increase rate (%)=medicine
Equal itch-threshold value-comparison mean value/comparison mean value × 100% (the results are shown in Table 3).The result shows that bamboo rat oil antipruritic powder poison cream
Mouse itch-threshold value can be increased substantially, there is good antipruritic effect.
Table 3. is on the antipruritic influence test result of mouse
Embodiment 8
A kind of bamboo rat oil antipruritic powder poison cream of preparation is clinically applied, as follows using step and effect:
1. object.Sting 69 of mosquito, show as red swelling of the skin, there is macula.12 of poisonous wasp sting, show as severe pain, itch, quilt
Skin enlargement at sting.
2. therapeutic scheme.Smear bamboo rat oil antipruritic powder poison cream, 3 times a day, successive administration 3-5d.
3. treatment results.What mosquito stung, the same day is antipruritic, red and swollen disappearance in the 3rd day.Poisonous wasp sting, pain, gargalesthesia disappear within the 2nd day
It loses, cures within the 5th day.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For member, the invention may be variously modified and varied.It is done within the spirit and principles of the present invention it is any modification, etc.
With replacement, improvement etc., should be included within scope of the invention.
Claims (8)
1. a kind of bamboo rat oil antipruritic powder poison cream, which is characterized in that including following raw material:
1) bamboo rat oil；
2) at least one antipruritic powder poison Chinese herbal medicine；
3) at least one stabilizer.
2. bamboo rat oil antipruritic powder poison cream according to claim 1, which is characterized in that the antipruritic powder poison Chinese herbal medicine is shaggy-fruited dittany
Skin, Sculellaria barbata, peppermint, Siberian cocklebur grass, cicada slough, radix paeoniae rubra, radix saposhnikoviae, kuh-seng, radices trichosanthis, semiaquilegia adoxoides, five color flower, Prunella vulgaris, wild chrysanthemum, branch
Son is one or more with viola mandshurica.
3. bamboo rat oil antipruritic powder poison cream according to claim 1, which is characterized in that the stabilizer is Glycerin, mixed triester with caprylic acid capric acid.
4. bamboo rat oil antipruritic powder poison cream according to claim 1, which is characterized in that the bamboo rat oil accounts for the quality of all raw materials
Percentage is not less than 20%.
5. bamboo rat oil antipruritic powder poison cream according to claim 4, which is characterized in that the bamboo rat oil accounts for the quality of all raw materials
Percentage is not less than 30%.
6. bamboo rat oil antipruritic powder poison cream according to claim 1, which is characterized in that the stabilizer accounts for the quality of all raw materials
Percentage is not less than 1%.
7. a kind of preparation method of bamboo rat oil antipruritic powder poison cream as claimed in claim 1 or 2, which is characterized in that including following step
It is rapid:
(1) each raw material is weighed；
(2) antipruritic powder poison Chinese herbal medicine is put into casserole, drinking water is added, after impregnating 20-30 minutes, added water and do not cross drug, it will
Casserole is placed on stove fire and decocts, and after boiling 40-50 minutes, medical fluid is poured out, and obtains first time medical fluid；
(3) warm water is added in casserole, is carried out second and is decocted, after boiling 30 minutes, pours out medical fluid, it is mixed with first time medical fluid
It closes, after natural cooling, after bamboo rat oil and stabilizer mixing is added, is boiled into paste, as a kind of Chinese medicine group agent bamboo rat cream.
8. a kind of bamboo rat oil antipruritic powder poison cream a kind of as claimed in any one of claims 1 to 6 is in preparation treatment mosquito, poisonous wasp etc.
It is applied in the drug to swell and ache caused by biting.
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| WO2022265414A1 (en) * | 2021-06-15 | 2022-12-22 | 이정호 | Therapeutic agent for bug bite and skin disease, comprising extracts of viola mandshurica and saxifraga stolonifera as active ingredients |
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| CN105816611A (en) * | 2016-04-15 | 2016-08-03 | 福建万亿店中店电子商务有限责任公司 | External use essential oil containing bamboo rat oil |
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