CN116115707B - Concentrated foam medicated bath liquid for preventing and treating cow hoof rot and preparation method thereof - Google Patents
Concentrated foam medicated bath liquid for preventing and treating cow hoof rot and preparation method thereof Download PDFInfo
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- CN116115707B CN116115707B CN202211632212.2A CN202211632212A CN116115707B CN 116115707 B CN116115707 B CN 116115707B CN 202211632212 A CN202211632212 A CN 202211632212A CN 116115707 B CN116115707 B CN 116115707B
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Abstract
The invention belongs to the technical field of veterinary disinfectant, and discloses a concentrated foam medicated bath liquid for preventing and treating cow foot rot, which is prepared from the following components in percentage by mass: 1-8% of polyhexamethylene biguanide hydrochloride, 1-2% of phthalic aldehyde, 12-20% of a traditional Chinese medicine extract, 5-10% of a cooling agent, 5-10% of a foaming agent, 1-3% of a foam stabilizer, 10-15% of an antifreezing agent, 1-3% of a pigment, 0.1-0.3% of a pH regulator and the balance of purified water; the traditional Chinese medicine extract is prepared from the following components in parts by weight: 3-5 parts of lotus leaf, 3-5 parts of dandelion, 2-3 parts of herba lycopi, 2-3 parts of radix semiaquilegiae, 1-2 parts of rhizoma bletillae and 1-2 parts of radix rehmanniae. The concentrated foam medicated bath liquid has the advantages of good visual hoof bath effect, high medicated bath liquid utilization rate, strong practicality, convenience, rapidness, low cost and the like.
Description
Technical Field
The invention belongs to the technical field of veterinary disinfectant, and relates to a concentrated foam medicated bath liquid for preventing and treating cow hoof rot and a preparation method thereof.
Background
Cow hoof rot is a highly contagious disease, and is caused by mixed infection of pathogenic bacteria such as clostridium necroseum and bacteroides pteronyssinus, and the like, so that skin between toes and deep soft tissues of the cow are suppurative and necrotic. The hoof rot of the dairy cows can cause various adverse consequences of premature elimination, delayed or stopped estrus, reduced milk yield, increased treatment cost and the like of the dairy cows, thereby causing huge economic loss to dairy farmers.
In actual production, cow breeders often do not actively take comprehensive precautions to prevent cow limb hoof problems or limb hoof diseases, and do not take therapeutic measures until the problems appear. At this time, the cows are already ill, the treatment process is complex, and the problem is difficult to solve. Therefore, precautions must be taken to avoid lameness and even paralysis of the cows, and the milk yield is suddenly reduced, so that the treatment cost of cow limb and hoof diseases is paid.
The hoof bath can play a double role in cleaning and sterilizing the hooves of cows, is an important hoof health care method, and can reduce the incidence rate of hoof diseases. The most common drugs used in traditional hoof baths are copper sulfate and formalin. However, copper sulfate causes heavy metal pollution to the environment, and formalin has carcinogenicity and irritation.
The concentrated foam medicated bath lotion is a novel hoof bath lotion and has the advantages of good adhesiveness and permeability, high cleaning and sterilizing efficiency, good observability and operability, convenient use, low cost and the like. The foam medicated bath liquid is contacted with the hooves of animals, and then the sterilization time is prolonged by the action modes of wetting, emulsifying, penetrating and the like, so that the deep cleaning and sterilization are completed. Moreover, the foam can be covered on the hooves of animals for a long time, and operators can clearly control the hoof bath process of the animals according to the covering condition of the foam, so that the observability is stronger. The cleaning and disinfecting of the hooves of animals are distinguished by the condition of adhering the medicated bath liquid foam to the hooves, so that the aim of visual medicated bath cleaning and disinfecting is fulfilled. When in use, a proper amount of concentrated solution is added into the hoof bath, 100-200 times of water is added, and ruminants walk through the hoof bath, thus the hoof rot can be prevented and treated.
Patent CN107837398A discloses a composite cow hoof bath lotion and a preparation method thereof, 5 parts of glutaraldehyde, 1 part of benzalkonium chloride, 1 part of copper sulfate, 1 part of zinc sulfate, 1 part of centella asiatica extract, 1 part of aluminum sulfate, 1 part of fatty alcohol-polyoxyethylene ether, 0.1 part of hydrochloric acid and 0.01 part of acid lake blue are mixed with 30 parts of deionized water, stirred for 2 hours and stood for 1 hour, thus obtaining the composite cow hoof bath lotion. The pH of the bath was 2.0. However, the composite cow hoof bath lotion contains copper sulfate which causes heavy metal pollution to the environment, does not contain components such as foaming agent, foam stabilizer, antifreezing agent and the like, is inconvenient to use and has no visual disinfection effect.
Patent CN108836938B discloses an environment-friendly composite foam hoof bath lotion and a preparation method thereof, and the bath lotion comprises the following components: 1 to 20 parts of glutaraldehyde, 1 to 20 parts of quaternary ammonium salt, 0.1 to 0.3 part of nano silver simple substance, 1 to 15 parts of foaming agent, 0.5 to 5 parts of foam stabilizer, 8 to 10 parts of polyol, 0.1 to 0.6 part of pigment and 10 to 30 parts of deionized water; the prepared foam hoof bath liquid is stable and not frozen in a low-temperature environment, is beneficial to the use and storage of the hoof bath liquid, contains sterilizing components which are retained for a longer time at the affected part, slowly infiltrates into the space between the toes of the animal, directly acts on the affected part, and effectively kills germs. However, glutaraldehyde in the prescription has stronger stimulation to eyes, skin and mucous membrane, and the simple substance of nano silver has higher cost.
Therefore, the concentrated foam medicated bath liquid for preventing and treating cow hoof rot, which has the advantages of good cleaning and sterilizing effects, convenient use and low cost, is developed, and has important significance in production practice of the breeding industry.
Disclosure of Invention
The invention aims to provide the concentrated foam medicated bath liquid for preventing and treating the cow hoof rot and the preparation method thereof, and the concentrated foam medicated bath liquid has the advantages of good visual hoof bath effect, high medicated bath liquid utilization rate, strong practicability, convenience, rapidness, low cost and the like.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
The invention provides a concentrated foam medicated bath liquid for preventing and treating cow foot rot, which is prepared from the following components in percentage by mass: 1 to 8 percent of polyhexamethylene biguanide hydrochloride, 1 to 2 percent of phthalic aldehyde, 12 to 20 percent of traditional Chinese medicine extract, 5 to 10 percent of cooling agent, 5 to 10 percent of foaming agent, 1 to 3 percent of foam stabilizer, 10 to 15 percent of antifreezing agent, 1 to 3 percent of pigment, 0.1 to 0.3 percent of pH regulator and the balance of purified water;
the traditional Chinese medicine extract is prepared from the following components in parts by weight: 3-5 parts of lotus leaf, 3-5 parts of dandelion, 2-3 parts of herba lycopi, 2-3 parts of semiaquilegia root, 1-2 parts of bletilla striata and 1-2 parts of dried rehmannia root.
In one embodiment, the cooling agent is a mixture of borneol and menthol.
In one technical scheme, the foaming agent is one of sodium laureth sulfate, sodium coco polyether sulfate or ammonium laureth sulfate.
In one embodiment, the foam stabilizer is one of cocamidopropyl betaine, lauropropyl betaine, cocamidopropyl amine oxide, or sodium cocamidopropionate.
In one embodiment, the antifreeze is glycerol.
In one technical scheme, the pigment is one of brilliant blue, gardenia blue or phycocyanin.
The invention also provides a preparation method of the concentrated foam medicated bath liquid for preventing and treating cow foot rot, which comprises the following steps:
Step 1: weighing the raw materials of the traditional Chinese medicine components according to the weight parts, adding 10 times of water to soak the raw materials of the traditional Chinese medicine components, decocting, and filtering decoction; decocting the residues with 10 times of water for 2 times, filtering the decoction, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol to reach ethanol content of 60%, stirring, and standing; collecting supernatant, recovering ethanol until no ethanol smell exists, and filtering to obtain Chinese medicinal extract;
Step 2: weighing the components in percentage by mass, adding purified water accounting for 30-40% of the total mass of the purified water into the traditional Chinese medicine extract, sequentially adding polyhexamethylene biguanide hydrochloride, phthalic dicarboxaldehyde, a foaming agent, a foam stabilizer, a cooling agent and an antifreezing agent, and uniformly stirring;
step 3: adding the rest purified water, pigment and pH regulator, regulating pH value to 3.5-6.5, and stirring to obtain concentrated foam medicated bath liquid for preventing and treating cow foot rot.
The medicinal bath lotion comprises the following components:
(1) The polyhexamethylene biguanide hydrochloride is a novel multipurpose bactericidal high molecular polymer, ionization can be generated in aqueous solution, the hydrophilic group part of the polyhexamethylene biguanide hydrochloride contains strong electropositivity, various bacteria and viruses which are usually electronegative are adsorbed, enter cell membranes, inhibit synthesis of liposome in the membranes, cause apoptosis of thalli, and achieve a good bactericidal effect. The polyhexamethylene biguanide hydrochloride has the characteristics of long-acting broad-spectrum killing and inhibiting various microorganisms, difficult generation of drug-resistant bacteria, low toxicity, no harm, no skin and mucous membrane irritation, no corrosion in surface treatment and the like.
(2) The phthalic dicarboxaldehyde is also called as a novel high-efficiency disinfectant OPA, can comprehensively replace glutaraldehyde, and has the following characteristics of 5:
1) Faster: the medicine is ready to use without activation, mixing or dilution; high-level disinfection is realized for 5 min; saving 50-75% time compared with glutaraldehyde; shortens the disinfection cycle period and improves the turnover rate.
2) Safer: no special ventilation device is needed; no OSHA allows for riot limits; no inhalation toxicity and mucous membrane toxicity; the wide use in the last decade has not been reported as acute toxicity, distortion and mutation.
3) More efficient: broad bactericidal efficacy; can kill 2% glutaraldehyde-tolerant Mycobacteria, especially Mycobacterium tortoise strains, in 5 minutes.
4) Milder: does not contain any surfactant; near neutral PH; wide material compatibility.
5) Longer lasting: at high load use, the average sustainable use disinfection cycle > glutaraldehyde (glutaraldehyde about 40 cycles).
(3) Borneol:
the main functions are as follows: promoting the flow of qi, inducing resuscitation, removing stagnated fire, removing nebula, improving eyesight, and relieving swelling and pain. For vomiting at middle wind gap, fever, coma, convulsion, epilepsy, phlegm-fan, deafness due to qi-obstruction, sore throat, aphtha, otitis media, carbuncle, hemorrhoids, nebula, enterobiasis. Channel tropism: enter heart and lung meridians. Sex taste: is bitter and cool.
1) Tang Ben Cao (Tang Ben Cao): pathogenic qi in the heart and abdomen, wind-dampness accumulation and deafness. Improving eyesight, removing conjunctival congestion and nebula. "
2) The preparation method comprises the following steps: "treating bone pain". "
3) Medical mirror about meeting ]: treating pain of limbs and joints. "
(4) Menthol:
The main functions are as follows: dispelling wind; clearing heat. Cold with wind-heat type; headache; conjunctival congestion; sore throat; tooth pain; itching of the skin. Sex taste: pungent taste; it is cool in nature.
Menthol can selectively stimulate cold receptors of human skin or mucous membrane to generate cold reflex and cold sense, and cause vasoconstriction of skin mucous membrane (in fact, skin remains normal); in addition, the blood vessels of deep tissues can also shrink, thereby producing a therapeutic effect. Can be used for external application to relieve inflammation, pain, itching, promote blood circulation, and relieve edema; the oral administration of the compound preparation can relieve local inflammation (sphagitis) and treat common cold, and has the effects of invigorating stomach and dispelling pathogenic wind.
(5) Glycerol:
The aqueous glycerol solution is the earliest and most conventional antifreeze. Glycerol has the advantage of being very toxic compared to other antifreeze agents such as propylene glycol. The glycerol can be used as an antifreezing agent and a moisturizing agent, can firmly lock water, forms a water film on the surface of skin, plays a role in moisturizing, and can also construct a protective film on the surface layer of the skin. Especially in winter, the glycerin can be used for rapidly nourishing and drying rough skin, so that the skin is relieved, moist and moist.
The traditional Chinese medicine extract of the invention is prepared from the following components:
(1) Folium Hibisci Mutabilis:
the main functions are as follows: clearing lung-heat and cooling blood; detoxify and detumescence. Cough due to lung heat; conjunctival congestion with swelling and pain; carbuncle and abscess; malignant sore; winding snake pill; impetigo herpetifomis; pyelonephritis; scalding by water and fire; venomous snake bite; traumatic injury. Sex taste: octyl; bitter; and (5) cooling. Channel tropism: a lung; the liver meridian.
1) Plum wine: the combined leaves of Hibiscus Mutabilis have the effects of smoothing qi, not cold or heat, slightly pungent and sliming and sticky nature, and are good at treating carbuncle and swelling. The name of the "Qing Lu san" and "Fu san" for treating sore and ulcer in recent past is also called Qing Gao, qing Lu san and Tie san. It is used to treat all kinds of carbuncles, malignant sores, etc. by treating them with honey, spreading them around the swelling area, leaving the head in the middle and changing the frequency of the dry process. The first person is cool and refreshing, and the pain is relieved. The already established one, pus and toxin are accumulated. The wearer is easy to astringe after pus is discharged. Or adding raw small red bean powder. ("outline of the invention
2) Huang Yuanyu: the cottonrose hibiscus has the effects of clearing and dissipating heat, and is good in treating sores and ulcers, and good in coating and drinking. ("Aronia herb solution
(2) Dandelion:
The main functions are as follows: clearing away heat and toxic materials, promoting urination and resolving hard mass. Can be used for treating acute mastitis, lymphadenitis, scrofula, furuncle, conjunctivitis, common cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection. Sex taste: bitter, sweet and cold. Channel tropism: enter the liver and stomach meridians.
1) The book of materia medica drawing channel: applied sore, it is indicated for malignant thorn and fox urine thorn.
2) Materia medica derived sense and complement: remove heat toxin, eliminate malignant tumor and tuberculosis, remove food toxin, and remove stagnation of qi.
3) Yunnan Ben Cao (materia Medica): applied on sores and toxic swelling, scabies and scabies, tinea and sores; dispelling wind, eliminating sore and toxic materials, and eliminating scrofula and tuberculosis; relieve hematochezia, treat five stranguria, uroschesis and promote urination.
4) Medicine codification: tonify spleen and stomach, purge fire, promote lactation and treat dysphagia.
5) Compendium mu Shiyi (compendium mu Yi): treat all venomous snake injuries.
6) Guangzhou army's manual of Chinese herbal medicine in common use: clear away heat and toxic materials, cool blood, induce diuresis, and promote lactation. It can be used for treating furuncle, skin ulcer, eye diseases, dyspepsia, constipation, snake and insect bite, and urinary tract infection.
7) Treating infantile malnutrition and furuncle: the dandelion is smashed and covered, and the juice is smashed and decocted with wine for taking sweat. ("outline of the invention
8) For many years, malignant sore and snake sting pyogenic infections: mashing herba Taraxaci, and sticking. ("first-aid square
(3) Herba Lycopi:
The main functions are as follows: promoting blood circulation to remove blood stasis; running water to reduce swelling; detoxify and cure carbuncle. Amenorrhea of housewives; dysmenorrhea; postpartum abdominal pain due to blood stasis; the abdominal mass and edema; traumatic injury; carbuncle, swelling and sore. Channel tropism: liver-tonifying; spleen meridian. Sex taste: bitter taste; octyl; slightly warm.
1) Ben Cao Jing Shu (materia Medica): herba Lycopi, bitter, with the actions of clearing heat, sweet, harmonizing blood, sour, entering liver, warming and activating nutrient-blood. With the assistance of spleen-tonifying herbs, fang Ji is used to treat ascites, edema of body surface and limbs, and water vapor in the condyle. It can also dispel heat and harmonize blood, and tonify qi in the middle energizer of Rihua (Rihua) and the drug property theory.
2) Materia medica Tongxuan (Xuan of materia Medica): herba Lycopi, fragrant, has effects of invigorating spleen, promoting qi, dredging liver, promoting blood circulation, and smoothing skin orifices, and is used as a female upper preparation.
3) Materia medica true: herba Lycopi, although it is a book with the wonderful effects of harmonizing blood and soothing spleen and growing and nourishing muscles, is a herb for treating spleen and promoting diuresis, liver and blood, and is characterized by nine orifices and orifices, joint energy, spleen and stomach energy, menstrual energy, edema and lumbodynia, postpartum blood stranguria and lumbago, hematemesis, epistaxis, eye pain, paralysis, carbuncle and toxicity and loss. In this respect, the book has the effect of soothing spleen and regulating blood, but it is also good at soothing spleen and regulating blood because of its effect of removing blood and removing blood. The flavor of tonifying qi and blood is same as that of tonifying qi, so that the stomach-qi is removed without damage to the healthy food.
4) Book of changes: internal hemorrhage of women, apoplexy Yu Ji, ascites, edema of body, limb, edema of joints, impetigo, carbuncle, swelling and suppuration.
5) Lei Pao Zhi Lun (Lei's treatise on preparation of Lei's treatise on preparation of drugs): it can break blood and promote digestion.
6) Japanese Sunji (Japanese Subtu) grass: inducing resuscitation, li Guanmai, nourishing blood, removing blood stasis, relieving symptoms, removing obstruction in the abdomen, promoting granulation, and eliminating blood stasis, and can be used for treating nasal Hong Tuxie, headache, eye pain, women fatigue, emaciation, and husband facial jaundice.
7) Medicine codification: liver and spleen tonifying, qi and blood activating, and tendons and vessels benefiting. Mainly treats the human blood, regulates menstruation and removes blood stasis.
8) Ling nan gatherer: for snake bite, it can dispel toxin and sore.
(4) Radix semiaquilegiae seed:
The main functions are as follows: clearing heat, detoxicating, detumescence, resolving hard mass and promoting urination. For treating carbuncle, scrofula, furuncle, stranguria with turbid urine, cough due to lung deficiency, hernia, epilepsy, infantile convulsion, hemorrhoid, and traumatic injury. The venomous snake bites. Channel tropism: enter liver and stomach meridians. Sex taste: sweet, bitter and cold.
1) Yunnan Ben Cao (materia Medica): the traditional Chinese medicine can be used for treating sores and swelling, attacking carbuncles, expelling pus and relieving pain, treating scrofula, dissipating tuberculosis, treating women's milk knot, breast milk obstruction, red swelling and pain, acute mastitis, and breast rock hardness such as stone, and is taken or dispersed or crumbled.
2) Bai Cao mirror (Bai Cao mirror): clearing heat, treating carbuncle, furuncle, traumatic injury, mad dog injury, hernia, hemorrhoid and strain.
3) Original asking of materia medica: it is good at dispelling phlegm fire, eliminating scrofula and malignant sore and soaking in wine.
4) "Guiyang folk medicinal herbs": clear away heat and toxic materials. It is indicated for epilepsy and snake bite.
5) "Guizhou herbal medicine: arresting convulsion, relieving pain, relieving asthma and detoxicating.
6) Chinese herbal medicine of Shanxi: "treating snake and insect bite, traumatic injury, lithangiuria and xerosis cutis". "
(5) Rhizoma bletillae:
The main functions are as follows: astringing to stop bleeding, detumescence and promoting granulation. Can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin; tuberculosis hemoptysis, ulcer bleeding. Channel tropism: it enters lung, liver and stomach meridians. Sex taste: bitter, sweet, astringent and slightly cold.
1) Compendium, compendium: bai Ji is astringent and can astringe, so it can enter lung to stop bleeding and promote tissue regeneration to treat sores.
2) Ben Cao Jing Shu (materia Medica): bletilla striata, bitter in taste, capable of dispelling heat, pungent in flavor and resolving hard mass, and carbuncle all result from the failure of qi to descend from the interior of the meat; the carbuncles are also known to be caused by heat accumulation and blood stasis due to yin deficiency and muscle death. Pathogenic qi in the stomach, i.e. pathogenic heat; the heat of the blood system is generated when the prickly heat of the thief is not recovered, and the damp-heat hurts yin, which is also caused by entering the blood system to dispel heat, dissipate nodulation and remove putrefaction, so that the condition of being slow and not enough.
3) Materia medica Hui Yan: bletilla tuber, rhizoma bletillae, with the actions of astringing qi, resolving phlegm, stopping bleeding and resolving carbuncles are also indicated. This herb is extremely sticky and greasy, extremely astringent, bitter and cold in flavor and good at entering lung meridian. When the lung lobes are damaged and the patient is ill due to heat accumulation and blood stasis, the lung can be healed, the lung can be hidden and filled, carbuncles and swelling can be eliminated, the death muscles can be removed, the pus and blood can be clean, and the medicine has the wonderful effect of supporting old and promoting tissue regeneration. For example, the adverse flow of lung qi, phlegm with fire with blood, and coma in the lung orifices and the trachea belong to the body of the airway, which is the principle of straightening the lung-heat, and the adverse flow of qi, phlegm and serum with fire self-withdrawal are all the more so if the medicine is used, the body is sticky and sealed, which is not beneficial.
4) Materia medica warp hundred species of record (L): the bletilla striata has light and smooth smell, and the physique is smooth and extremely sticky, enters into the tendons and bones, can nourish and nourish the body smoothly, and is regulated with the healthy qi, so that the pathogenic factors can be eliminated.
5) Materia medica true: the rhizoma bletillae, the prescription book has the functions of entering the lung to stop bleeding and also has the functions of treating traumatic fracture, soup fire burn, malignant sore, carbuncle, abscess and carbuncle, and dead muscle of carbuncle, which are not similar to but not similar to those of the other, are not similar to those of the other, and are similar to those of the other? The bleeding stopping function is also called as astringent and astringent; for abscess, deep-rooted carbuncle and injury, it is also called pungent and energy-resolving powder. The medicine has the functions of astringing middle energizer, tonifying middle energizer, removing putrefaction, removing blood stasis and promoting tissue regeneration.
6) Ben Cao Zhengyi (materia Medica): bai Ji (rhizoma Bletillae), ben Jing (book of meridian), fu Ling (carbuncle, malignant sore, abscess, cellulitis), and Shang Ying Ji (miscellaneous records) are externally applied and mixed with drugs. Bitter and pungent taste and cold nature, so it can dispel carbuncle and swelling due to blood heat; is sticky and greasy, and can treat dead muscle of cellulite; being bitter and pungent, it can kill parasites, so it is also the key herb for relieving swelling and promoting tissue regeneration besides Bai Xuan and Jie Sheng. For pathogenic qi in stomach, bitter and cold herbs can remove heat in the ears. However, the thief has slow and undeveloped miliaria, and is not dared to strengthen the solution. For lung abscess, it is bitter and cold in nature and can tonify lung and stomach, and when the flame is extreme, it can be used for tonifying and clearing both the bad smell and smell of phlegm, and it is also suitable for both winter and fragrant solomonseal rhizome.
7) Drug Property theory (L): for excessive heat, it is indicated for flaccidity of yin and yang, and for facial eruption, muscle slip.
8) Tang Ben Cao (Tang Ben Cao): the hands and feet are cracked and chewed for coating.
9) Japanese Sunji (Japanese Subtu) grass: stopping convulsion, blood evil, epilepsy, conjunctival congestion, tuberculosis, scrofula, intestinal wind, hemorrhoids and fistula, knife and arrow sore, warm malaria, bloody dysentery, shang Huochuang, promoting granulation, relieving pain and wind arthralgia.
10 Main herb figure channel: for the treatment of the non-cure of golden sore and abscess, it is used in the recipe.
(6) Radix rehmanniae:
the main functions are as follows: clear heat and cool blood, nourish yin and promote the production of body fluid. Can be used for treating pyretic diseases, deep-red tongue, polydipsia, yin deficiency, internal heat, bone steaming, internal heat, diabetes, hematemesis, epistaxis, and macula. Channel tropism: it enters heart, liver and kidney meridians. Sex taste: sweet and cold.
1) Treating traumatic fracture: mashing radix rehmanniae, ironing and heating, and is easy for people day and night. If blood is collected, it is treated with needles. ("sanitary easy simple square
2) Treating injury of limb, broken tendons and bones, but with skin connected: grinding radix rehmanniae into juice, taking with wine, and continuously treating one month's tendons and skin; and pestle and smash, stir-fry the heat-sealing damage. ("sanitary easy simple square
3) To dredge channels, tonify deficiency, strengthen feet and knees, moisten skin: juice is extracted from radix rehmanniae, and radix Achyranthis bidentatae is processed into powder two by two. The medicine is added, stirred uniformly, decocted in a silver stone device, and can be made into pills, such as phoenix tree seed big pill. Every time thirty pills are taken, the wine is taken before eating. ("Puji Fang
Compared with the prior art, the invention has the following advantages:
1. the concentrated foam medicated bath liquid consists of a disinfectant, a compound traditional Chinese medicine hoof care agent, a cooling agent, a foaming agent, a foam stabilizer, an antifreezing agent, pigment, a pH regulator and purified water, and has the advantages of good visual hoof bath effect, high utilization rate of the medicated bath liquid, strong practicability, convenience, rapidness, low cost and the like.
2. The disinfectant in the prescription of the invention comprises polyhexamethylene biguanide hydrochloride and phthalic aldehyde, has strong sterilization and disinfection capability, is safe and non-irritating to human and livestock, and achieves the purpose of preventing and treating ruminant hoof rot.
3. The traditional Chinese medicine extract in the prescription of the invention is derived from cottonrose hibiscus leaves, dandelion, herba lycopi, semiaquilegia root, rhizoma bletillae and radix rehmanniae. The medicines are found in the Chinese herbal medicine, so that the medicine is safe and effective. The hibiscus leaves and dandelion have the effects of clearing away heat and toxic materials; herba Lycopi and radix Semiaquilegiae; bletilla striata, dried rehmannia root, radix rehmanniae, and the like, and has the effects of stopping bleeding and promoting tissue regeneration; the medicines are combined, and the purposes of clearing heat and detoxicating, detumescence and expelling pus, stopping bleeding and promoting tissue regeneration are achieved, so that the aim of treating both symptoms and root causes is fulfilled, the ruminant hoof rot is prevented and treated, hoof health care is performed, and the income of farmers is increased.
4. The cooling agent in the prescription of the invention comprises borneol and menthol, not only can bring cool and comfortable feeling to the hooves of ruminants, but also has the effects of aromatic corrosion prevention and dirt removal.
5. The foaming agent and the foam stabilizer in the prescription can lead the foam of the medicated bath liquid to be fine and rich, have strong adhesive force and double penetration, and increase the contact time of the medicated bath liquid with the hooves and pathogenic microorganisms of ruminants, thereby realizing more efficient and thorough cleaning and disinfection effects; the pigment makes the foam more visual, and the medicated bath process is easier to control; the antifreezing agent ensures that the medicated bath liquid is not easy to freeze in winter in the north, and is more convenient to use.
Drawings
FIG. 1 is a chart showing the foaming force test of the foam bath foam of examples 1, 4, 7 to 8 and comparative example 4 according to the present invention.
Detailed Description
The following examples are illustrative of the present invention and are not intended to limit the scope of the invention. The technical means used in the examples are conventional means well known to those skilled in the art unless otherwise indicated. The test methods in the following examples are conventional methods unless otherwise specified.
Example 1
Taking 1kg of foam medicated bath liquid as an example, weighing the following components in percentage by mass:
The preparation steps of the concentrated foam medicated bath liquid are as follows:
Step 1: weighing the following traditional Chinese medicine component raw materials in parts by weight: 150g of hibiscus leaves, 250g of dandelion, 110g of herba lycopi, 100g of semiaquilegia root, 50g of rhizoma bletillae and 100g of dried rehmannia root, adding 10 times of water to soak the traditional Chinese medicine component raw materials, decocting and filtering the decoction; decocting the residues with 10 times of water for 2 times, filtering the decoction, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol to reach ethanol content of 60%, stirring, and standing; collecting supernatant, recovering ethanol until no ethanol smell exists, and filtering to obtain Chinese medicinal extract;
step 2: adding purified water accounting for 35 percent of the total mass of the purified water into the traditional Chinese medicine extract, sequentially adding polyhexamethylene biguanide hydrochloride, phthalic dicarboxaldehyde, a foaming agent, a foam stabilizer, a cooling agent and an antifreezing agent according to the mass percent, and uniformly stirring; step 3: adding the rest purified water, pigment and pH regulator by mass percent, regulating the pH value to 4.5, and uniformly stirring to obtain the concentrated foam medicated bath liquid for preventing and treating cow foot rot.
Example 2
Taking 1kg of foam medicated bath liquid as an example, weighing the following components in percentage by mass:
The procedure for the preparation of the concentrated foam medicated bath was as described in example 1.
Example 3
Taking 1kg of foam medicated bath liquid as an example, weighing the following components in percentage by mass:
The procedure for the preparation of the concentrated foam medicated bath was as described in example 1.
Example 4
Taking 1kg of foam medicated bath liquid as an example, weighing the following components in percentage by mass:
The preparation steps of the concentrated foam medicated bath liquid are as follows:
step 1: weighing the following traditional Chinese medicine component raw materials in parts by weight: 150g of hibiscus leaves, 250g of dandelion, 125g of herba lycopi, 125g of semiaquilegia root, 60g of rhizoma bletillae and 90g of dried rehmannia root, adding 10 times of water to soak the traditional Chinese medicine component raw materials, decocting and filtering the decoction; decocting the residues with 10 times of water for 2 times, filtering the decoction, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol to reach ethanol content of 60%, stirring, and standing; collecting supernatant, recovering ethanol until no ethanol smell exists, and filtering to obtain Chinese medicinal extract;
Step 2: weighing the components of the foam medicated bath lotion according to the mass percentage, adding purified water accounting for 30-40% of the total mass of the purified water into the traditional Chinese medicine extract, sequentially adding polyhexamethylene biguanide hydrochloride, phthalic dicarboxaldehyde, a foaming agent, a foam stabilizer, a cooling agent and an antifreezing agent, and uniformly stirring;
Step 3: adding the rest purified water, pigment and pH regulator, adjusting pH to 4, and stirring to obtain concentrated foam medicated bath liquid for preventing and treating cow hoof rot.
Example 5
The composition and the amount of the foam medicated bath liquid in this example are the same as those in example 4, except that the amounts of the components used for preparing the traditional Chinese medicine extract are different, and the preparation steps of the concentrated foam medicated bath liquid are as follows:
Step 1: weighing the following traditional Chinese medicine component raw materials in parts by weight: 180g of hibiscus leaves, 210g of dandelion, 100g of herba lycopi, 130g of semiaquilegia root, 85g of rhizoma bletillae and 95g of radix rehmanniae, adding 10 times of water to soak the traditional Chinese medicine component raw materials, decocting and filtering the decoction; decocting the residues with 10 times of water for 2 times, filtering the decoction, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol to reach ethanol content of 60%, stirring, and standing; collecting supernatant, recovering ethanol until no ethanol smell exists, and filtering to obtain Chinese medicinal extract;
Step 2: weighing the components of the foam medicated bath lotion according to the mass percentage, adding purified water accounting for 30-40% of the total mass of the purified water into the traditional Chinese medicine extract, sequentially adding polyhexamethylene biguanide hydrochloride, phthalic dicarboxaldehyde, a foaming agent, a foam stabilizer, a cooling agent and an antifreezing agent, and uniformly stirring;
Step 3: adding the rest purified water, pigment and pH regulator, adjusting pH to 4, and stirring to obtain concentrated foam medicated bath liquid for preventing and treating cow hoof rot.
Example 6
The composition and the dosage of the foam medicated bath liquid in the embodiment are the same as those of the foam medicated bath liquid in the embodiment 4, except that the dosage of each component in the traditional Chinese medicine extract is different, and the preparation steps of the concentrated foam medicated bath liquid are as follows:
Step 1: weighing the following traditional Chinese medicine component raw materials in parts by weight: 225g of hibiscus leaf, 200g of dandelion, 125g of herba lycopi, 100g of semiaquilegia root, 75g of rhizoma bletillae and 75g of dried rehmannia root, adding 10 times of water to soak the traditional Chinese medicine component raw materials, decocting and filtering the decoction; decocting the residues with 10 times of water for 2 times, filtering the decoction, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol to reach ethanol content of 60%, stirring, and standing; collecting supernatant, recovering ethanol until no ethanol smell exists, and filtering to obtain Chinese medicinal extract;
Step 2: weighing the components of the foam medicated bath lotion according to the mass percentage, adding purified water accounting for 30-40% of the total mass of the purified water into the traditional Chinese medicine extract, sequentially adding polyhexamethylene biguanide hydrochloride, phthalic dicarboxaldehyde, a foaming agent, a foam stabilizer, a cooling agent and an antifreezing agent, and uniformly stirring;
Step 3: adding the rest purified water, pigment and pH regulator, adjusting pH to 4, and stirring to obtain concentrated foam medicated bath liquid for preventing and treating cow hoof rot.
Example 7
Taking 1kg of foam medicated bath liquid as an example, the foam medicated bath liquid of the embodiment comprises the following components in percentage by mass:
The procedure for the preparation of the concentrated foam medicated bath was as described in example 1.
Example 8
Taking 1kg of foam medicated bath liquid as an example, the foam medicated bath liquid of the embodiment comprises the following components in percentage by mass:
The procedure for the preparation of the concentrated foam medicated bath was as described in example 1.
Comparative example 1
The mass percent of polyhexamethylene biguanide hydrochloride was reduced from 8% to 0.1% compared to example 8, otherwise the same as in example 8.
Comparative example 2
In comparison with example 8, the components for preparing the Chinese medicinal extract lacked the cotton rose leaves, and the other components were the same as in example 8.
Comparative example 3
In comparison with example 8, the fraction from which the herbal extract was prepared lacks the semiaquilegia root, otherwise identical to example 8.
Comparative example 4
The mass percent of sodium laureth sulfate foaming agent is reduced from 10% to 1% compared with example 8, and the other steps are the same as in example 8.
Experimental example 1 acute oral toxicity test of mice
The test basis is as follows: disinfection technical Specification (2002 edition) 2.3.1.
Sample treatment and dosage preparation: the foam medicated bath products of examples 1, 4, and 7-8 were 100-fold diluted with the application liquid.
Test animals: kunming mice, clean grade, body weight 18 g-22 g,80, male and female halves. Provided by the department of medicine laboratory animal center of the university of western security traffic, laboratory animal pass number: 937.
The administration mode is as follows: the test substance is orally administrated at a dose of 20mL/kg by taking a dose early the next day after being fasted overnight (free drinking water).
The experimental steps are as follows: 80 mice (male and female halves) were given a gastric lavage dose of 5000mg/kg body weight at a time, and the death and poisoning were recorded after 14 days of observation.
Results: 80 mice (male and female halves) showed no obvious poisoning symptoms during the 14 day observation period, no death, and no obvious abnormality in general anatomy. The results are shown in Table 1.
TABLE 1 results of acute oral toxicity test of foam medicated bath
Results: the foam medicated bath liquid of the invention is diluted 100 times to apply the liquid to the acute oral LD 50 of mice which is more than 5000mg/kg body weight. According to the acute oral toxicity grading standard, the application liquid of the product prepared by the invention belongs to the actual non-toxic grade for acute oral toxicity of mice.
Experimental example 2: one-time complete skin irritation test
The test basis is as follows: disinfection technical Specification (2002 edition) 2.3.3.
Sample treatment and dosage preparation: examples 1,4, and 7-8 foam medicated bath products.
Test animals: new Zealand exempts, common grade, 12 male rabbits, weight 2.0 kg-3.0 kg, by Shaanxi Jun line biotechnology limited commonly provided, pass number: 61003200000478.
The test operation steps are as follows: the hairs on two sides of the spine of the back of an animal are removed by a pet trimmer 2 hours before the test, the hair removal range is about 3cm multiplied by 3cm respectively, the skin is checked to be intact, 0.5mL of a test object is directly coated on the hair removal skin on one side of a rabbit on the next day, the coating area is 2.5cm multiplied by 2.5cm, then 4 layers of gauze and a layer of sulfuric acid paper are covered on the test object, and the test object is fixed by using a non-irritating adhesive tape: the other side served as a blank, and after 4 hours the residual test object was removed with warm water. Skin irritation responses were observed and scored 1h, 24h, 48h after removal of the test subjects, respectively. The results are shown in Table 2.
TABLE 2 reaction of the products of example 1, example 4, examples 7-8 to one skin irritation of rabbits
Conclusion: the average integral of the skin irritation response of the products of examples 1, 4 and 7-8 to the rabbit once is 0, and the products of examples 1, 4 and 7-8 are non-irritating according to the skin irritation intensity grading standard.
Experimental example 3: the concentrated foam medicated bath liquid of the invention can prevent cow hoof rot
650 Cows with uniform ages and weights and healthy hooves are selected in a dairy farm, the cows are randomly divided into 13 groups, 50 cows in each group are added into hoof baths in a control group, the concentrated foam medicinal bath liquid and 150 times of water are added into the hoof baths in other groups, hoof baths are carried out for 4 times per week, and the hoof rot disease rate of the cows in each group is counted after 12 weeks of use.
Table 3 statistics of the treatment of swine fever with different veterinary drug particles
| Group of | Milk cow (head) | Cow (head) with foot rot disease | Susceptibility to foot rot |
| Example 1 | 50 | 1 | 2％ |
| Example 2 | 50 | 2 | 4％ |
| Example 3 | 50 | 1 | 2％ |
| Example 4 | 50 | 1 | 2％ |
| Example 5 | 50 | 2 | 4％ |
| Example 6 | 50 | 1 | 2％ |
| Example 7 | 50 | 1 | 2％ |
| Example 8 | 50 | 2 | 4％ |
| Comparative example 1 | 50 | 9 | 18％ |
| Comparative example 2 | 50 | 8 | 16％ |
| Comparative example 3 | 50 | 6 | 12％ |
| Comparative example 4 | 50 | 5 | 10％ |
| Control group | 50 | 11 | 22％ |
The result shows that the control effect on the ruminant hoof rot is not greatly different by mobilizing the proportion of each active ingredient in the protection range. However, if the proportion of disinfectant or the proportion of traditional Chinese medicine extract or the proportion of certain auxiliary materials is reduced at will, the prevention and treatment effect on ruminant hoof rot will be poor. The concentrated foam medicated bath liquid consists of disinfectant, chinese medicine extract, cooling agent, foaming agent, foam stabilizer, antifreezing agent, pigment, pH regulator and purified water, and has obvious prevention and treatment effect on ruminant hoof rot and can effectively reduce the incidence rate of hoof rot.
Experimental example 4: foaming force and foam stabilizing performance test
After foam formation, the surface is adhered, and organic biological films on the surface of the object are decomposed through complex physical and chemical actions such as wetting, infiltration, emulsification, suspension, deflocculation, dispersion and solubilization and the like, and the adhesion force between objects and the surface tension between solid and liquid are reduced; meanwhile, bacteria and viruses on the surface and in the gaps are killed and disinfected by the disinfecting component. The foaming power of the concentrated foam medicated bath liquid for preventing and treating ruminant hoof rot has a key effect on the sterilization effect.
The concentrated foam medicated bath products for preventing and treating ruminant hoof rot of examples 1,4, 7-8 and comparative example 4 were diluted 200 times to reach the use concentration, and the foaming power test was performed according to GB/T13173-2021 surfactant detergent test method, the results of which are shown in FIG. 1.
As can be seen from fig. 1, the foaming forces and foam stabilizing properties of examples 1, 4 and 7 to 8 are not greatly different; the foaming power and foam stabilizing performance of comparative example 4 were significantly lowered. Therefore, the foaming agent has important influence on the foaming force and the foam stabilizing performance.
The above-mentioned embodiments are merely preferred embodiments of the present invention, which are not intended to limit the scope of the present invention, and other embodiments can be easily made by those skilled in the art through substitution or modification according to the technical disclosure in the present specification, so that all changes and modifications made in the principle of the present invention shall be included in the scope of the present invention.
Claims (7)
1. The concentrated foam medicated bath liquid for preventing and treating cow hoof rot is characterized by comprising the following components in percentage by mass: 1-8% of polyhexamethylene biguanide hydrochloride, 1-2% of phthalic aldehyde, 12-20% of a traditional Chinese medicine extract, 5-10% of a cooling agent, 5-10% of a foaming agent, 1-3% of a foam stabilizer, 10-15% of an antifreezing agent, 1-3% of a pigment, 0.1-0.3% of a pH regulator and the balance of purified water;
the traditional Chinese medicine extract is prepared from the following components in parts by weight: 3-5 parts of lotus leaf, 3-5 parts of dandelion, 2-3 parts of herba lycopi, 2-3 parts of semiaquilegia root, 1-2 parts of rhizoma bletillae and 1-2 parts of radix rehmanniae;
The preparation method of the traditional Chinese medicine extract comprises the following steps: weighing the raw materials of the traditional Chinese medicine components according to the weight parts, adding 10 times of water to soak the raw materials of the traditional Chinese medicine components, decocting, and filtering decoction; decocting the residues with 10 times of water for 2 times, filtering the decoction, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol to reach ethanol content of 60%, stirring, and standing; collecting supernatant, recovering ethanol until no ethanol smell is present, and filtering to obtain the final product.
2. The concentrated foam medicated bath solution for preventing and treating cow hoof rot of claim 1, wherein the cooling agent is a mixture of borneol and menthol.
3. The concentrated foam medicated bath for preventing and treating cow hoof rot of claim 1, wherein the foaming agent is one of sodium laureth sulfate, sodium coco polyether sulfate, or ammonium laureth sulfate.
4. The concentrated foam medicated bath for controlling cow hoof rot of claim 1, wherein the foam stabilizer is one of cocamidopropyl betaine, lauropropyl betaine, cocamidopropyl amine oxide, or sodium cocamidopropionate.
5. The concentrated foam medicated bath for preventing and treating cow hoof rot of claim 1, wherein the antifreeze is glycerol.
6. The concentrated foam medicated bath for preventing and treating cow hoof rot of claim 1, wherein the pigment is one of brilliant blue, gardenia blue or phycocyanin.
7. The preparation method of the concentrated foam medicated bath liquid for preventing and treating cow hoof rot of any one of claims 1-6, which is characterized by comprising the following steps:
Step 1: weighing the raw materials of the traditional Chinese medicine components according to the weight part of claim 1, adding 10 times of water to soak the raw materials of the traditional Chinese medicine components, decocting and filtering decoction; decocting the residues with 10 times of water for 2 times, filtering the decoction, and mixing filtrates; concentrating the filtrate under reduced pressure to obtain extract, adding ethanol to reach ethanol content of 60%, stirring, and standing; collecting supernatant, recovering ethanol until no ethanol smell exists, and filtering to obtain Chinese medicinal extract;
Step 2: weighing the components in percentage by mass as claimed in claim 1, adding purified water accounting for 30-40% of the total mass of the purified water into the traditional Chinese medicine extract, sequentially adding polyhexamethylene biguanide hydrochloride, phthalic dicarboxaldehyde, a foaming agent, a foam stabilizer, a cooling agent and an antifreezing agent, and uniformly stirring;
step 3: adding the rest purified water, pigment and pH regulator, regulating pH value to 3.5-6.5, and stirring to obtain concentrated foam medicated bath liquid for preventing and treating cow foot rot.
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| CN111265562A (en) * | 2020-04-15 | 2020-06-12 | 河南省康星药业股份有限公司 | Hoof bath liquid for daily prevention of hoof diseases of animals and preparation method and application thereof |
| CN111407789A (en) * | 2020-04-15 | 2020-07-14 | 河南省康星药业股份有限公司 | Foam type bath lotion for daily prevention and treatment of animal hooves as well as preparation method and application thereof |
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| CN111265562A (en) * | 2020-04-15 | 2020-06-12 | 河南省康星药业股份有限公司 | Hoof bath liquid for daily prevention of hoof diseases of animals and preparation method and application thereof |
| CN111407789A (en) * | 2020-04-15 | 2020-07-14 | 河南省康星药业股份有限公司 | Foam type bath lotion for daily prevention and treatment of animal hooves as well as preparation method and application thereof |
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| Title |
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| 国内外兽用消毒剂的研究现状与发展趋势;邱梅 等;中国兽药杂志;第45卷(第06期);43-47.60 * |
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