CN111184832A - Plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests and preparation method thereof - Google Patents

Plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests and preparation method thereof Download PDF

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Publication number
CN111184832A
CN111184832A CN202010112120.6A CN202010112120A CN111184832A CN 111184832 A CN111184832 A CN 111184832A CN 202010112120 A CN202010112120 A CN 202010112120A CN 111184832 A CN111184832 A CN 111184832A
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parts
nourishing
functions
protecting
lubricating
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阮海连
方荣如
方子喻
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Jiangxi Linfeng Pharmaceutical Co ltd
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Jiangxi Linfeng Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483—Gleditsia (locust)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

A plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests and a preparation method thereof are disclosed, wherein the raw materials for preparing active ingredients of the composition comprise: 10-25 parts of Chinese honeylocust pod, 12-25 parts of bletilla striata, 12-25 parts of Chinese gall, 13-25 parts of fructus cnidii, 18-28 parts of pomegranate bark, 8-18 parts of nardostachys chinensis, 13-23 parts of rhizoma kaempferiae, 8-18 parts of dragon bone, 18-35 parts of luffa stem, 18-35 parts of phyllanthus urinaria, 18-28 parts of persimmon bark, 8-18 parts of nano silver, 5-10 parts of lactobacillus, 3-10 parts of bifidobacterium, 2-9 parts of sodium chloride, 12-22 parts of carbomer and 2-8 parts of triethanolamine. The technical scheme of the invention can improve female vaginal relaxation, prevent and treat gynecological inflammation and maintain the functions of an ovary reproductive system.

Description

Plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests and preparation method thereof
Technical Field
The invention relates to a gynecological external medicine, in particular to a preparation formula with functions of contracting vagina, lubricating, nourishing and protecting the ovary and a preparation method thereof.
Background
Women are difficult to avoid after delivery, particularly after natural delivery, so that vaginal relaxation is caused, the sexual life quality is greatly reduced, and a plurality of couples have uncoordinated sexual life, thereby causing a plurality of social problems. In addition, after delivery, the vaginal orifice expands, the postpartum repair is not good, various pathogenic bacteria infection is easily caused, gynecological diseases are caused, the body health is influenced, and the family harmony is realized. Diseases of the reproductive system are gynecological diseases, and for example, vaginitis and the like are common diseases and frequently encountered diseases of women. However, many people lack due knowledge of gynecological diseases, lack of health care of the body, and various bad living habits and habits, so that the physiological health of the people is gradually improved, some female diseases are entangled and cannot be cured for a long time, and great inconvenience is brought to normal life and work.
At present, surgical and pharmaceutical methods are mainly used for improving vaginal relaxation. Wherein, the operation method is easy to cause complications and has great harm to human body; the existing medicine method comprises vaginal injection and medicine filling, and the method has the defects of quick response, short lasting medicine effect and harm to human bodies. The traditional Chinese medicines and western medicines for treating gynecological inflammation are more, and the embolism-type medicines of the western medicines have single effect and are easy to have drug resistance and irritation; some Chinese patent medicines have single function and insignificant effect.
Disclosure of Invention
The invention aims to provide a health care medicine which has reasonable and scientific raw material compatibility for preparing active ingredients of the medicine, can improve female vaginal relaxation, prevent and treat gynecological inflammation and maintain the functions of an ovary reproductive system.
The invention relates to a plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests and a preparation method thereof, and the technical scheme is realized as follows:
the medicine is prepared from the following active ingredients in parts by weight:
10-25 parts of Chinese honeylocust pod, 12-25 parts of bletilla striata, 12-25 parts of Chinese gall, 13-25 parts of fructus cnidii, 18-28 parts of pomegranate bark, 8-18 parts of nardostachys chinensis, 13-23 parts of rhizoma kaempferiae, 8-18 parts of dragon bone, 18-35 parts of luffa stem, 18-35 parts of phyllanthus urinaria, 18-28 parts of persimmon bark, 8-18 parts of nano silver, 5-10 parts of lactobacillus, 3-10 parts of bifidobacterium, 2-9 parts of sodium chloride, 12-22 parts of carbomer and 2-8 parts of triethanolamine.
Further, the plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests is prepared from the following active ingredients in parts by weight:
15-20 parts of Chinese honeylocust fruit, 15-20 parts of bletilla striata, 15-20 parts of Chinese gall, 15-20 parts of fructus cnidii, 20-25 parts of pomegranate bark, 10-15 parts of nardostachys chinensis, 15-20 parts of rhizoma kaempferiae, 10-15 parts of dragon bone, 20-30 parts of luffa stem, 20-30 parts of phyllanthus urinaria, 20-25 parts of persimmon bark, 10-15 parts of nano silver, 7-9 parts of lactobacillus, 5-8 parts of bifidobacterium, 3-8 parts of sodium chloride, 15-20 parts of carbomer and 3-6 parts of triethanolamine.
Further, the plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests is prepared from the following active ingredients in parts by weight:
18 parts of Chinese honeylocust pod, 18 parts of bletilla striata, 18 parts of Chinese gall, 18 parts of common cnidium fruit, 22 parts of pomegranate bark, 12 parts of nardostachys chinensis, 18 parts of rhizoma kaempferiae, 12 parts of dragon bone, 25 parts of luffa stem, 25 parts of phyllanthus niruri, 22 parts of persimmon bark, 12 parts of nano-silver, 8 parts of lactobacillus, 6 parts of bifidobacterium, 5 parts of sodium chloride, 18 parts of carbomer and 5 parts of triethanolamine.
Furthermore, the plant probiotic composition with the functions of contracting vagina, lubricating, nourishing and protecting the ovary is in a gel paste form.
The invention also provides a preparation method of the preparation formula with functions of contracting vagina, lubricating, nourishing and protecting the ovary, which comprises the following steps:
(1) decocting fructus Gleditsiae Abnormalis, rhizoma Bletillae, Galla chinensis, fructus Cnidii, pericarpium Granati, radix Et rhizoma Nardostachyos, rhizoma Kaempferiae, Os Draconis, ramulus Luffae, herba Phyllanthi Urinariae, and pericarpium kaki with purified water for 2 times, extracting at low temperature, mixing filtrates, filtering, concentrating to obtain extract, diluting with ethanol, recovering ethanol, concentrating to obtain ethanol extract, diluting with purified water, standing, filtering to obtain filtrate A;
(2) soaking nano silver and carbomer in purified water for dissolving, and filtering to obtain filtrate B;
(3) adding the solution A into the solution B, stirring and mixing uniformly, adding lactobacillus, bifidobacterium and sodium chloride, stirring and dissolving fully, putting into a vacuumizing biological reaction kettle, keeping the temperature at 40 ℃ for 2 hours, cooling to 20 ℃, adding purified water to certain volume, stirring and mixing uniformly, cooling and vacuumizing, measuring the pH value, and adjusting the pH value to 5-7 by using triethanolamine; standing for 24 hours, and then sterilizing and subpackaging.
Further, in the step (1), the time for decocting the purified water is 2 hours each time, 8 times of the amount of the purified water is added for the first time, and 6 times of the amount of the purified water is added for the second time.
Further, in the step (1), the relative density of the extract obtained by concentration is 1.1-1.2, the temperature is 60 ℃, and the ethanol used for dilution and extraction is 95% ethanol which is 6 times of that used for dilution and extraction.
Further, the relative density of the alcohol paste obtained by concentration is 1.1-1.2, and the temperature is 60 ℃; diluting the alcohol paste with appropriate amount of purified water, and standing for 12 hr.
The botanical drug materials used in the present invention: the Chinese honeylocust pod, the bletilla striata, the gallnut, the common cnidium fruit, the pomegranate rind, the nardostachys chinensis bunge, the rhizoma kaempferiae, the keel, the luffa stem, the phyllanthus niruri and the persimmon rind have the functions of clearing away heat and toxic materials, diminishing inflammation, resisting ulcer, resisting diseases, nourishing yin and contracting vagina, have good treatment effects on vaginal dryness and laxity, and can enhance the pleasure of sexual life of couples. In the formula, Chinese honey locust is taken as a monarch drug, bletilla striata and Chinese gall are taken as ministerial drugs, and common cnidium fruit, pomegranate rind, nardostachys chinensis, rhizoma kaempferiae, dragon bone, luffa stem, phyllanthus niruri and persimmon rind are taken as assistants to enhance the efficacy. The recipe is scientific in compatibility and remarkable in clinical use effect.
Gleditsia sinensis pod: pungent taste and warm nature; it enters lung and large intestine meridians. Has effects of loosening bowel to relieve constipation, dispelling pathogenic wind, clearing heat, eliminating phlegm and resolving hard mass. Pharmacological research shows that the product has anti-inflammatory and antibacterial effects.
Bletilla striata: bitter and sweet, cool and enter lung meridian. Has the effects of tonifying lung, stopping bleeding, relieving swelling, promoting granulation, and healing sore. Can be used for treating female leukorrhagia and leukorrhagia. Pharmacological research shows that the composition has hemostatic and antibacterial effects, and can inhibit Staphylococcus aureus, Bacillus subtilis, Candida albicans, Trichophyton and human type tubercle bacillus.
Gallnut: sour, astringent, cold; it enters lung, large intestine and kidney meridians. Has the functions of astringing the lung; stopping sweating; astringing intestines; securing essence; hemostasis is carried out; and (4) detoxifying. Can be used for treating proctoptosis, spermatorrhea, whitish and turbid urine, metrorrhagia, carbuncle, swelling, sore, and furuncle. Pharmacological research shows that the compound has antibacterial effect, and in vitro tests show that the compound has obvious antibacterial or bactericidal effect on staphylococcus aureus, streptococcus, pneumococcus, typhoid fever, paratyphoid fever, dysentery, anthrax, diphtheria, pseudomonas aeruginosa and the like.
Fructus cnidii: pungent, bitter and warm herbs enter kidney meridian. Warming kidney and strengthening yang, drying dampness, dispelling wind and killing parasites. Can be used for treating cold womb, leukorrhagia due to cold-dampness, and lumbago due to damp arthralgia; externally treating vulvar eczema and pruritus vulvae of women; trichomonas vaginitis. Pharmacological research shows that the compound has the functions of resisting trichomonas, having sex hormone-like effect, delaying senility, inhibiting smooth muscle contraction, preventing and treating osteoporosis, calming, hypnotizing and the like.
Pomegranate rind: sour, astringent and warm, entering the large intestine meridian. Has effects of astringing intestine, stopping bleeding, and expelling parasites. Can be used for treating chronic diarrhea, chronic dysentery, hematochezia, rectocele, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to parasitic infestation, and scabies. The clinical application of the composition in treating various infectious inflammations shows that the composition has the effects of expelling parasites, resisting bacteria, fungi and viruses.
And (3) rhizoma nardostachyos: sweet and warm, entering spleen and stomach meridians. Has effects of regulating qi-flowing, relieving pain, resolving stagnation and activating spleen. Pharmacological research shows that the essential oil has the effects of tranquilizing the center and resisting arrhythmia, the volatile oil has weak antibacterial, wind-dispelling and spasmolytic effects, and no local irritation to skin and mucosa; the alcohol extract has blood pressure lowering and antiulcer effects.
And (3) rhizoma kaempferiae: pungent and warm herbs enter stomach meridian. Has the effects of warming middle energizer, promoting digestion and relieving pain. Pharmacological research shows that the compound has the functions of resisting cancer, inhibiting bacteria and stimulating smooth muscle contraction.
Keel: sweet, astringent and neutral, entering heart, liver, kidney and large intestine meridians. Has effects of tranquilizing, arresting sweating, promoting granulation, and healing sore. Can be used for treating neurasthenia, insomnia, dreaminess, night sweat, metrorrhagia, metrostaxis, and leukorrhagia. Pharmacological research shows that the composition has the effects of promoting blood coagulation, reducing permeability of blood vessel walls and inhibiting excitation of skeletal muscles.
Luffa stem: sweet and neutral. Has effects of dredging meridian passage, relieving cough and eliminating phlegm, and can be used for treating menoxenia. Pharmacological research finds that the traditional Chinese medicine composition has the effects of relieving cough, eliminating phlegm, resisting bacteria, relieving cough and relieving asthma.
Pearl grass: sweet in taste; cool in nature, dispelling wind and relieving cough; clear heat and promote diuresis, regulate middle warmer and benefit lung. Pharmacological studies show that the medicine can correct anemia of diabetics, reduce hyperphosphatemia and reduce hypercholesteremia.
Persimmon peel: astringent and mild in nature. It has effects in clearing away heat and toxic materials, and stopping bleeding; mainly descend blood.
Nano silver: the nano silver has strong penetrating power, can fully contact and attack pathogens comprehensively, thereby exerting stronger biological effect, and has the advantages of high safety, wide antibacterial range, long lasting sterilization time and the like. The antibacterial property of the nano silver is far greater than that of the traditional silver ion bactericide in killing pathogenic bacilli, cocci and myceliums. The nano silver particles can kill pathogenic microorganisms such as bacteria, fungi, mycoplasma, chlamydia and the like. Broad-spectrum sterilization, lasting sterilization effect, capability of killing 650 bacteria and promoting wound healing, no drug resistance, rapidness and high efficiency. Has strong permeability, can rapidly permeate into subcutaneous 2mm for sterilization, and has good sterilization effect on deeper tissue infection caused by common bacteria, stubborn bacteria, drug-resistant bacteria and fungi. Fast and high efficiency, and can be combined with the cell wall/membrane of bacteria quickly to make enzyme lose activity and die. The sterilization rate reaches 100 percent; the minimum inhibitory concentration is 2 mg/kg.
And (3) lactobacillus: the vaginal lactobacillus is a very common medicine, the main component of the vaginal lactobacillus is the live lactobacillus, and the vaginal lactobacillus is very helpful for treating vaginal diseases caused by various bacteria.
Bifidobacteria: the bifidobacterium is used as a physiological beneficial bacterium and has the functions of biological barrier and lubrication and nutrition for human reproductive health.
The materials are matched, the drug effects complement each other, the vagina nursing and nursing functions are achieved synchronously, and the vagina nursing and nursing effects on killing vagina pathogenic bacteria, contracting vagina and lubricating vagina can be achieved really.
Compared with the prior art, the invention has the advantages that: fructus gleditsiae pod is used as a monarch drug, bletilla striata gallnut is used as a ministerial drug, fructus cnidii, pomegranate rind, rhizoma nardostachyos, rhizoma kaempferiae, keel, luffa stem, phyllanthus urinaria and persimmon rind are used as assistants to enhance the efficacy, the compatibility is scientific, the drug effects complement each other, a good synergistic effect can be generated, and the clinical use effects of shrinking yin and lubricating, nourishing and protecting the nest and preventing and treating gynecological inflammation are achieved; the preparation process is reasonable, the extraction raw material essence is adopted for concentration, and the content of the active ingredients is high. The production process is simple, and the production cost is reduced.
Detailed Description
In order that the objects, features, advantages and effects achieved by the present invention will be readily apparent and fully understood, specific embodiments of the present invention will be described.
The first embodiment is as follows:
a plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests is prepared from the following active ingredients in parts by weight: 15 parts of Chinese honeylocust pod, 15 parts of bletilla striata, 15 parts of Chinese gall, 15 parts of common cnidium fruit, 20 parts of pomegranate bark, 10 parts of nardostachys chinensis, 15 parts of rhizoma kaempferiae, 10 parts of dragon bone, 20 parts of luffa stem, 20 parts of phyllanthus niruri, 20 parts of persimmon bark, 10 parts of nano-silver, 7 parts of lactobacillus, 5 parts of bifidobacterium, 3 parts of sodium chloride, 15 parts of carbomer and 3 parts of triethanolamine.
The preparation method of the preparation comprises the following steps:
(1) decocting 15 parts of Chinese honeylocust fruit, 15 parts of bletilla striata, 15 parts of Chinese gall, 15 parts of common cnidium fruit, 20 parts of pomegranate bark, 10 parts of nardostachys root, 15 parts of kaempferia galangal, 10 parts of dragon bone, 20 parts of luffa stem, 20 parts of phyllanthus urinaria and 20 parts of persimmon bark with purified water for 2 times, 2 hours each time, adding 8 times of purified water for the first time and 6 times of purified water for the second time, extracting at low temperature, combining filtrates, filtering, concentrating to obtain an extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, diluting and extracting with 6 times of 95% ethanol, recovering ethanol, concentrating to obtain an alcohol extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, diluting the alcohol extract with a proper amount of purified water, standing for 12 hours, and filtering to obtain a filtrate A for later use;
(2) soaking 10 parts of nano silver and 15 parts of carbomer in purified water for dissolving, and filtering to obtain filtrate B for later use;
(3) adding the solution A into the solution B, stirring and mixing uniformly, adding 7 parts of lactobacillus, 5 parts of bifidobacterium and 3 parts of sodium chloride, stirring and dissolving fully, putting into a vacuumizing biological reaction kettle, keeping the temperature at 40 ℃ for 2 hours, cooling to 20 ℃, adding purified water to certain volume, stirring and mixing uniformly, cooling and vacuumizing, measuring the pH value, and adjusting the pH value by using 3 parts of triethanolamine; standing for 24 hours, and then sterilizing and subpackaging.
Example two:
a plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests is prepared from the following active ingredients in parts by weight: 20 parts of Chinese honeylocust pod, 20 parts of bletilla striata, 20 parts of Chinese gall, 20 parts of common cnidium fruit, 25 parts of pomegranate bark, 15 parts of nardostachys chinensis, 20 parts of rhizoma kaempferiae, 15 parts of dragon bone, 30 parts of luffa stem, 30 parts of phyllanthus niruri, 25 parts of persimmon bark, 15 parts of nano-silver, 9 parts of lactobacillus, 8 parts of bifidobacterium, 8 parts of sodium chloride, 20 parts of carbomer and 6 parts of triethanolamine.
The preparation method of the preparation comprises the following steps:
(1) decocting fructus Gleditsiae Abnormalis 20 parts, rhizoma Bletillae 20 parts, Galla chinensis 20 parts, fructus Cnidii 20 parts, pericarpium Granati 25 parts, rhizoma Nardostachyos 15 parts, rhizoma Kaempferiae 20 parts, Os Draconis 15 parts, ramulus Luffae 30 parts, herba Phyllanthi 30 parts, and exocarpium kaki 25 parts with purified water for 2 times, 2 hr each time, adding 10 times of purified water for the first time and 8 times of purified water for the second time, extracting at low temperature, mixing filtrates, filtering, concentrating to obtain extract with relative density of 1.1-1.2 and temperature of 60 deg.C, diluting with 6 times of 95% ethanol, recovering ethanol, concentrating to obtain ethanol extract with relative density of 1.1-1.2 and temperature of 60 deg.C, diluting with appropriate amount of purified water, standing for 12 hr, and filtering to obtain filtrate A;
(2) soaking and dissolving 15 parts of nano silver and 20 parts of carbomer in purified water, and filtering to obtain filtrate B for later use;
(3) adding the solution A into the solution B, stirring and mixing uniformly, adding 9 parts of lactobacillus, 8 parts of bifidobacterium and 8 parts of sodium chloride, stirring and dissolving fully, putting into a vacuumizing biological reaction kettle, keeping the temperature at 40 ℃ for 2 hours, cooling to 20 ℃, adding purified water to certain volume, stirring and mixing uniformly, cooling and vacuumizing, measuring the pH value, and adjusting the pH value to 5-7 by using triethanolamine; standing for 24 hours, and then sterilizing and subpackaging.
Example three:
a plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests is prepared from the following active ingredients in parts by weight: 18 parts of Chinese honeylocust pod, 18 parts of bletilla striata, 18 parts of Chinese gall, 18 parts of common cnidium fruit, 22 parts of pomegranate bark, 12 parts of nardostachys chinensis, 18 parts of rhizoma kaempferiae, 12 parts of dragon bone, 25 parts of luffa stem, 25 parts of phyllanthus niruri, 22 parts of persimmon bark, 12 parts of nano-silver, 8 parts of lactobacillus, 6 parts of bifidobacterium, 5 parts of sodium chloride, 18 parts of carbomer and 5 parts of triethanolamine.
The preparation method of the preparation comprises the following steps:
(1) decocting 18 parts of Chinese honeylocust pod, 18 parts of bletilla striata, 18 parts of Chinese gall, 18 parts of common cnidium fruit, 22 parts of pomegranate bark, 12 parts of nardostachys root, 18 parts of kaempferia galangal, 12 parts of dragon bone, 25 parts of luffa stem, 25 parts of phyllanthus urinaria and 22 parts of persimmon bark with purified water for 2 times, 2 hours each time, adding 9 times of purified water for the first time and 7 times of purified water for the second time, extracting at low temperature, combining filtrates, filtering, concentrating to obtain an extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, diluting and extracting with 6 times of 95% ethanol, recovering ethanol, concentrating to obtain an alcohol extract with the relative density of 1.1-1.2 and the temperature of 60 ℃, diluting the alcohol extract with a proper amount of purified water, standing for 12 hours, and filtering to obtain a filtrate A for later use;
(2) soaking and dissolving 12 parts of nano silver and 18 parts of carbomer in purified water, and filtering to obtain filtrate to obtain solution B for later use;
(3) adding the solution A into the solution B, stirring and mixing uniformly, adding 8 parts of lactobacillus, 6 parts of bifidobacterium and 5 parts of sodium chloride, stirring and dissolving fully, putting into a vacuumizing biological reaction kettle, keeping the temperature at 40 ℃ for 2 hours, cooling to 20 ℃, adding purified water to certain volume, stirring and mixing uniformly, cooling and vacuumizing, measuring the pH value, and adjusting the pH value to 5-7 by using triethanolamine; standing for 24 hours, and then sterilizing and subpackaging.
The first test example:
1. a subject: 60 female patients with one or more of the following symptoms were symptomatically diagnosed: pruritus vulvae, restless sitting and lying, frequent micturition, odynuria, abnormal leucorrhea, and vaginal discharge as white floccule or thick slag-like discharge; the age is 28-50 years old; there are no serious primary diseases and mental diseases of heart, blood vessel, liver and kidney.
2. The test method comprises the following steps: clinical observations
Each patient was administered 5ml once in the morning and at night, intravaginally with one of the formulations of examples 1-3, for a 90-day trial period. During observation, the subject needs to maintain reasonable dietary structure and work and rest system, and other non-observed medicines are forbidden.
3. The curative effect standard is as follows:
and (3) curing: disappearance or substantial disappearance of symptoms, signs;
the effect is shown: the symptoms and physical signs are obviously changed;
the method has the following advantages: symptoms and physical signs are all improved;
and (4) invalidation: symptoms and physical signs are not obviously improved.
4. As a result:
result categories Cure of disease Show effect Is effective Invalidation Total effective rate
Number of 55 3 2 0 100％
And (4) conclusion: after 90 days, the feedback symptoms of 60 tested persons disappear or are obviously improved, and the effective rate reaches 100 percent according to the treatment result.
Test example two
1. A subject: 20 volunteer women are selected as a subject in an outpatient department of obstetrics and gynecology, and the subject has symptoms of vaginal relaxation and poor muscle elasticity due to production or age problems; the aged 35-49 years old, and has no serious primary diseases such as cardiovascular disease, liver disease, kidney disease, etc. and psychosis disease.
2. The test method comprises the following steps: clinical observations
The symptoms of the subjects before and after the test were recorded, the natural conditions were checked by a gynecologist, and the subjects were washed externally with the formulation of example three, once in the morning and at night, 5ml each time, and the course of the test was 90 days.
3. Evaluation criteria
The effect is shown: the vagina shrinks obviously and becomes narrow and restores the elasticity of muscles;
the method has the following advantages: vaginal contraction narrows or restores muscle tone;
and (4) invalidation: the vagina contracts to be uniform or the muscle elasticity is unchanged before and after the experiment.
4. Results
Result categories Show effect Is effective Invalidation Total effective rate
Number of 17 2 1 95％
The preparation obtained by the third embodiment of the invention has obvious effect on solving the problems of vaginal relaxation and poor muscle elasticity, and the effective rate is 95%.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (8)

1. A plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests is characterized by being prepared from the following active ingredients in parts by weight:
10-25 parts of Chinese honeylocust pod, 12-25 parts of bletilla striata, 12-25 parts of Chinese gall, 13-25 parts of fructus cnidii, 18-28 parts of pomegranate bark, 8-18 parts of nardostachys chinensis, 13-23 parts of rhizoma kaempferiae, 8-18 parts of dragon bone, 18-35 parts of luffa stem, 18-35 parts of phyllanthus urinaria, 18-28 parts of persimmon bark, 8-18 parts of nano silver, 5-10 parts of lactobacillus, 3-10 parts of bifidobacterium, 2-9 parts of sodium chloride, 12-22 parts of carbomer and 2-8 parts of triethanolamine.
2. The plant probiotic composition with the functions of contracting vagina, lubricating, nourishing and protecting nests as claimed in claim 1, is characterized by being prepared from the following active ingredients in parts by weight:
15-20 parts of Chinese honeylocust fruit, 15-20 parts of bletilla striata, 15-20 parts of Chinese gall, 15-20 parts of fructus cnidii, 20-25 parts of pomegranate bark, 10-15 parts of nardostachys chinensis, 15-20 parts of rhizoma kaempferiae, 10-15 parts of dragon bone, 20-30 parts of luffa stem, 20-30 parts of phyllanthus urinaria, 20-25 parts of persimmon bark, 10-15 parts of nano silver, 7-9 parts of lactobacillus, 5-8 parts of bifidobacterium, 3-8 parts of sodium chloride, 15-20 parts of carbomer and 3-6 parts of triethanolamine.
3. The plant probiotic composition with the functions of contracting vagina, lubricating, nourishing and protecting nests as claimed in claim 2, is characterized by being prepared from the following active ingredients in parts by weight:
18 parts of Chinese honeylocust pod, 18 parts of bletilla striata, 18 parts of Chinese gall, 18 parts of common cnidium fruit, 22 parts of pomegranate bark, 12 parts of nardostachys chinensis, 18 parts of rhizoma kaempferiae, 12 parts of dragon bone, 25 parts of luffa stem, 25 parts of phyllanthus niruri, 22 parts of persimmon bark, 12 parts of nano-silver, 8 parts of lactobacillus, 6 parts of bifidobacterium, 5 parts of sodium chloride, 18 parts of carbomer and 5 parts of triethanolamine.
4. The plant probiotic composition with the functions of contracting vagina, lubricating, nourishing and protecting nests as claimed in any one of claims 1 to 3, wherein the formulation is cream.
5. A method for preparing the formulation of any one of claims 1-3 for vagina-contracting, lubrication, and nidus-nourishing and nidus-protecting, comprising the steps of:
(1) decocting fructus Gleditsiae Abnormalis, rhizoma Bletillae, Galla chinensis, fructus Cnidii, pericarpium Granati, radix Et rhizoma Nardostachyos, rhizoma Kaempferiae, Os Draconis, ramulus Luffae, herba Phyllanthi Urinariae, and pericarpium kaki with purified water for 2 times, extracting at low temperature, mixing filtrates, filtering, concentrating to obtain extract, diluting with ethanol, recovering ethanol, concentrating to obtain ethanol extract, diluting with purified water, standing, filtering to obtain filtrate A;
(2) soaking nano silver and carbomer in purified water for dissolving, and filtering to obtain filtrate B;
(3) adding the solution A into the solution B, stirring and mixing uniformly, adding lactobacillus, bifidobacterium and sodium chloride, stirring and dissolving fully, putting into a vacuumizing biological reaction kettle, keeping the temperature at 40 ℃ for 2 hours, cooling to 20 ℃, adding purified water to certain volume, stirring and mixing uniformly, cooling and vacuumizing, measuring the pH value, and adjusting the pH value to 5-7 by using triethanolamine; standing for 24 hours, and then sterilizing and subpackaging.
6. The preparation method of the formulation with functions of contracting vagina, lubricating, nourishing and protecting the ovary as claimed in claim 5, wherein: in the step (1), the time for decocting the purified water is 2 hours each time, 8 times of the amount of the purified water is added for the first time, and 6 times of the amount of the purified water is added for the second time.
7. The preparation method of the formulation with functions of contracting vagina, lubricating, nourishing and protecting the ovary as claimed in claim 6, wherein: in the step (1), the relative density of the extract obtained by concentration is 1.1-1.2, the temperature is 60 ℃, and the ethanol used for dilution and extraction is 95% ethanol which is 6 times of that used for dilution and extraction.
8. The preparation method of the formulation with functions of contracting vagina, lubricating, nourishing and protecting the ovary as claimed in claim 7, wherein: the relative density of the alcohol paste obtained by concentration is 1.1-1.2, and the temperature is 60 ℃; diluting the alcohol paste with appropriate amount of purified water, and standing for 12 hr.
CN202010112120.6A 2020-02-24 2020-02-24 Plant probiotic composition with functions of contracting vagina, lubricating, nourishing and protecting nests and preparation method thereof Pending CN111184832A (en)

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Publication number Priority date Publication date Assignee Title
CN112316017A (en) * 2020-11-19 2021-02-05 陕西康乐实业有限公司 Gynecological antibacterial gel and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN1939518A (en) * 2006-10-12 2007-04-04 胡木明 Herbal curing liquid for female monthly period and daily use with vagina contraction, sterilizing and antipruritic functions

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CN1939518A (en) * 2006-10-12 2007-04-04 胡木明 Herbal curing liquid for female monthly period and daily use with vagina contraction, sterilizing and antipruritic functions

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Application publication date: 20200522