CN114342965A - Traditional Chinese medicine composition for repelling mosquitoes and preparation method thereof - Google Patents
Traditional Chinese medicine composition for repelling mosquitoes and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for repelling mosquitoes and a preparation method thereof, and relates to the technical field of pharmaceutical preparations. The traditional Chinese medicine composition for repelling mosquitoes comprises the following raw materials: perilla leaf, elsholtzia, mint, agastache rugosus, amomum cardamomum, lavender, dried orange peel, rosemary, fennel, lemongrass, clove, pepper and grassleaf sweelflag rhizome. The traditional Chinese medicine composition has good mosquito repelling effect, no side effect and low possibility of forming drug resistance. According to the preparation method, the raw materials are aged and crushed, so that volatile substances of the medicinal materials can volatilize conveniently, the volatile substances can repel or kill mosquitoes, the medicinal materials do not need to be in direct contact with the skin, the safety of the traditional Chinese medicine composition in use is improved, side effects are almost avoided, and meanwhile, the medicinal materials are natural components, so that the possibility of forming drug resistance is low.
Description
Technical Field
The invention relates to the technical field of medicinal preparations, in particular to a traditional Chinese medicine composition for repelling mosquitoes and a preparation method thereof.
Background
In summer, the high-temperature and damp-heat mosquitoes breed, people are easy to be bitten by the mosquitoes, the mosquitoes can stab the skin through the mouth organ, the saliva or the leachate of the venom contains a plurality of antigen components, the antigen components can generate allergic reaction with antibodies to cause inflammation after entering the skin of a human body, and the itching of an affected part is often caused by the inflammation. In order to relieve itching, people involuntarily grab the affected part, often resulting in skin scratching, and skin breakage is easy to cause infection. Besides the problems of blood absorption and disturbance to people, mosquitoes are also the transmission vectors of various infectious diseases such as yellow fever, malaria, encephalitis B, dengue fever and the like.
The existing various anthelmintic drugs are mostly prepared from chemical components, which not only have certain side effects, but also cause pollution to the environment. After some insect repellents are used for a long time, the mosquitoes or flying insects can generate drug resistance, so that the insect prevention effect is reduced.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for repelling mosquitoes, which has good mosquito repelling effect, no side effect and low possibility of forming drug resistance.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for repelling mosquitoes, which is characterized in that the raw materials are cured and crushed, so that volatile substances of the medicinal materials can be volatilized conveniently, the volatile substances can repel or kill mosquitoes, the medicinal materials do not need to be in direct contact with skin, the safety of the traditional Chinese medicine composition in use is improved, side effects are almost avoided, and meanwhile, the medicinal materials are all natural components, so that the possibility of forming drug resistance is low.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
The invention provides a traditional Chinese medicine composition for repelling mosquitoes, which comprises the following raw materials in parts by weight: 40-60 parts of perilla leaf, 45-55 parts of elsholtzia, 45-58 parts of mint, 35-50 parts of wrinkled gianthyssop herb, 35-45 parts of round cardamom, 25-35 parts of lavender, 5-15 parts of dried orange peel, 15-30 parts of rosemary, 15-25 parts of fennel, 45-60 parts of lemon grass, 10-20 parts of clove, 5-20 parts of pepper and 5-15 parts of grassleaf sweelflag rhizome.
The invention provides a preparation method of a traditional Chinese medicine composition for repelling mosquitoes, which comprises the following steps:
aging the raw materials at 70-80 deg.C for 5-10min, and pulverizing to particle size less than 1mm to obtain powder.
The embodiment of the invention at least has the following beneficial effects:
in the invention, the perilla leaf has the effects of dispersing wind-cold, promoting qi circulation and regulating the middle warmer. Herba Moslae has effects of inducing sweat, relieving exterior syndrome, dispelling summerheat, and eliminating dampness. Herba Menthae has effects of dispelling pathogenic wind and heat, refreshing mind, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Agastache rugosus has the effects of relieving exterior syndrome, relieving summer-heat, removing dirt, regulating the middle warmer, resolving dampness and enlivening spleen. Bai Dou kou has the actions of resolving dampness, activating qi-flowing, warming middle energizer and arresting vomiting. Lavender has tranquilizing, antibacterial and spasmolytic effects. Pericarpium Citri Tangerinae has effects of regulating qi-flowing, regulating stomach, eliminating dampness and eliminating phlegm. Rosemary has the effects of tranquilizing and allaying excitement, harmonizing stomach and relieving pain. Fennel has the effects of dispelling cold, relieving pain, regulating qi and harmonizing stomach. The herba Cymbopogonis Citrari has effects of invigorating stomach, promoting diuresis, and resisting bacteria and virus. Flos Caryophylli has effects of warming middle energizer, lowering adverse qi, dispelling cold, and relieving pain. The pricklyash peel has the effects of sterilization and disinsection. Rhizoma Acori Graminei has effects of inducing resuscitation, eliminating dampness, regulating stomach function, tranquilizing mind, and improving intelligence. The medicinal materials are matched for use, the drug effects are mutually synergistic, the effects of killing insects and resisting bacteria, dispelling summer heat and eliminating dampness and calming and refreshing are better, the proportion of the medicinal materials is reasonable, and the mosquito-repellent effect of the traditional Chinese medicine composition is better.
According to the invention, through curing the raw materials, the medicinal properties of the medicinal materials are milder, the water content of the medicinal materials is reduced, the deterioration of the medicinal materials is avoided, and the service life of the traditional Chinese medicine composition is prolonged. Through crushing, volatile substances of the medicinal materials are better volatilized, the concentration of the volatile substances in the air is improved, and the mosquito repelling effect of the traditional Chinese medicine composition is better. Meanwhile, the medicinal materials do not need to be directly contacted with the skin, so that the safety of the traditional Chinese medicine composition in use is improved, almost no side effect exists, and meanwhile, the medicinal materials are all natural components, so that the possibility of forming drug resistance is low.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
A traditional Chinese medicine composition for repelling mosquitoes comprises the following raw materials in parts by weight: 40-60 parts of perilla leaf, 45-55 parts of elsholtzia, 45-58 parts of mint, 35-50 parts of wrinkled gianthyssop herb, 35-45 parts of round cardamom, 25-35 parts of lavender, 5-15 parts of dried orange peel, 15-30 parts of rosemary, 15-25 parts of fennel, 45-60 parts of lemon grass, 10-20 parts of clove, 5-20 parts of pepper and 5-15 parts of grassleaf sweelflag rhizome.
Perilla leaf, warm in nature and pungent in flavor, enters lung channel and spleen channel, and has the effects of relieving exterior syndrome, dispelling cold, promoting qi circulation and harmonizing stomach. Folium Perillae has tranquilizing and antipyretic effects; can inhibit the excitability membrane; can promote secretion of digestive juice and enhance gastrointestinal peristalsis; has the effects of relieving cough, eliminating phlegm and relieving asthma on the respiratory system, and has the double effects of stopping bleeding and resisting coagulation on the blood system; increase blood glucose; regulating organism immunity, and resisting mutagenesis; antimicrobial, having a broad spectrum of antimicrobial action; has slight inhibition effect on adenylate cyclase and strong xanthine oxidase inhibition effect; has remarkable antioxidation effect; also has antiinflammatory effect.
Herba Moslae, warm in nature and pungent in flavor, enters lung and stomach meridians, and has the effects of inducing sweat, relieving exterior syndrome, regulating the middle warmer and promoting diuresis. Herba Moslae has antipyretic and analgesic effects; has inhibitory effect on isolated intestine; can enhance the immunity of the organism; has strong broad-spectrum antibacterial effect and certain antiviral effect; the inhibitor has obvious inhibition effect on angiotensin receptor beta-hydroxy-beta-methylglutarate coenzyme A reductase in vitro, and may have the effects of reducing blood pressure and cholesterol; also has diuretic, antitussive and expectorant effects.
Mint is cool in nature and pungent in flavor, and has the effects of dispelling wind, dissipating heat, removing dirt and detoxifying. The main chemical component of the mint is menthol, and the menthol can be used for treating headache, neuralgia, pruritus and the like by local application; when applied to the skin, the skin feels cool firstly and then slightly pricked and burned, and the cool feeling is not caused by the reduction of the skin temperature but is caused by the stimulation of the cold receptors of nerve endings. The alcoholic solution of menthol has antiseptic effect. It has some therapeutic effects on respiratory inflammation, probably due to its enhanced secretion to remove mucus attached to the mucosa. Menthone is more irritating than menthol.
Agastache rugosus is slightly warm in nature and pungent in taste, enters lung channel, spleen channel and stomach channel, and has the effects of quickening qi, regulating the middle warmer, repelling dirt and dispelling dampness. The chemical component contains volatile oil, whose main component is methyl piperonyl alcohol, accounting for more than 80%, and contains anethole, anisaldehyde, limonene, p-methoxy cinnamaldehyde, etc. The herba Agastaches decoction has effect in inhibiting various pathogenic fungi such as Trichophyton schoenleinii, and the ether extract and alcohol extract can also inhibit various pathogenic fungi. The flavonoids in herba Agastaches have antiviral effect.
Fructus Amomi rotundus, warm in nature and pungent in flavor, enters lung and spleen channels, has effects of activating qi-flowing, warming stomach, resolving food stagnation, and relieving epigastric distention, and can be used for treating qi stagnation, dyspepsia, chest distress, abdominal distention, belching, dysphagia, vomiting, regurgitation, malaria.
Lavender is cool in nature and pungent in taste, has the effects of clearing heat, removing toxicity, dispelling wind and relieving itching, and is mainly used for treating headache, dizziness, mouth and tongue sores, throat red and swollen, scalds, rubella and scab. The lavender is called 'the king of all grass', has fresh and elegant fragrance and mild property, and is a plant which is acknowledged to have the effects of calming, soothing and hypnotizing; can relieve tension, calm mind, heal wound, remove scar, control oil, regenerate, diminish inflammation, and repair.
The dried orange peel is pungent in flavor, bitter in taste and warm in nature, enters spleen channels and lung channels, and has the effects of regulating qi, stimulating appetite, eliminating dampness and reducing phlegm. The pericarpium Citri Tangerinae can regulate digestive system; exciting heart, enhancing myocardial contraction force, inhibiting heart rate due to excessive dosage, and increasing coronary blood flow; has certain prevention effect on arteriosclerosis caused by high fat diet; relieving asthma and eliminating phlegm; the renal blood vessels are contracted, and the urine volume is reduced; inhibiting in vitro uterus, and relaxing uterus at high concentration; enhancing immune function; anti-inflammatory; the bleeding and blood coagulation time is shortened; can promote secretion of digestive juice such as saliva and gastric juice, and eliminate intestinal gas accumulation.
Rosemary has tranquilizing, refreshing and diuretic effects, and can be used for treating insomnia, palpitation, headache, dyspepsia, etc., and for treating trauma and arthritis; also has heart strengthening, metabolism promoting, and peripheral blood vessel blood circulation promoting effects; can also improve the disorders of language, vision and hearing, enhance attention, treat rheumatalgia, strengthen liver function, reduce blood sugar, be helpful for treating arteriosclerosis and recovering the activity of paralytic limbs.
Fennel is pungent, sweet and warm in flavor and has the functions of regulating qi, invigorating stomach, dispelling cold and relieving pain. The main components of the health food are protein, fat, dietary fiber, anethole, fenchone, anisaldehyde and the like. It can stimulate gastrointestinal nerve and blood vessels, promote saliva and gastric secretion, stimulate appetite, and promote digestion; also has effects of warming liver and kidney, warming stomach, and dispelling cold. Wherein, the anethole and the anisaldehyde have fragrance and good effect on expelling mosquitoes and ants.
Lemon grass is a herb with lemon aroma. The trace elements contained in the product have antiinflammatory, antibacterial, digestion promoting, and dyspepsia relieving effects. The fragrance of lemon grass has mosquito repelling effect.
Clove, pungent in taste, warm in nature, entering stomach, spleen and kidney meridians, has the effects of warming middle-jiao, lowering adverse qi, tonifying kidney and supporting yang, can inhibit bacteria, kill parasites, relieve pain and the like, and has the inhibition effect on various pathogenic fungi, cocci, streptococcus, bacilli such as pneumonia, dysentery, large intestine, typhoid fever and influenza viruses.
The pepper is mainly pepper leaves, is bitter in taste, cold in nature and non-toxic, has a good dispersing function, and can effectively clear heat and dissipate fire. The pricklyash leaves contain volatile vegetable oil, and can effectively sterilize, resist bacteria, kill insects and the like. Meanwhile, the pepper leaves also have the effects of promoting blood circulation by removing blood stasis and clearing and activating the channels and collaterals.
Rhizoma Acori Graminei, slightly warm in nature, pungent and bitter in taste, enters heart and stomach meridians, and has effects of inducing resuscitation, eliminating phlegm, regulating qi-flowing, promoting blood circulation, dispelling pathogenic wind, and eliminating dampness. The product mainly contains volatile oil, and safrole in the volatile oil has the effect of expelling parasites.
The folium Perillae has effects of dispelling pathogenic wind and cold, activating qi-flowing and regulating stomach. Herba Moslae has effects of inducing sweat, relieving exterior syndrome, dispelling summerheat, and eliminating dampness. Herba Menthae has effects of dispelling pathogenic wind and heat, refreshing mind, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Agastache rugosus has the effects of relieving exterior syndrome, relieving summer-heat, removing dirt, regulating the middle warmer, resolving dampness and enlivening spleen. Bai Dou kou has the actions of resolving dampness, activating qi-flowing, warming middle energizer and arresting vomiting. Lavender has tranquilizing, antibacterial and spasmolytic effects. Pericarpium Citri Tangerinae has effects of regulating qi-flowing, regulating stomach, eliminating dampness and eliminating phlegm. Rosemary has the effects of tranquilizing and allaying excitement, harmonizing stomach and relieving pain. Fennel has the effects of dispelling cold, relieving pain, regulating qi and harmonizing stomach. The herba Cymbopogonis Citrari has effects of invigorating stomach, promoting diuresis, and resisting bacteria and virus. Flos Caryophylli has effects of warming middle energizer, lowering adverse qi, dispelling cold, and relieving pain. The pricklyash peel has the effects of sterilization and disinsection. Rhizoma Acori Graminei has effects of inducing resuscitation, eliminating dampness, regulating stomach function, tranquilizing mind, and improving intelligence. The medicinal materials are matched for use, the drug effects are mutually synergistic, the effects of killing insects and resisting bacteria, dispelling summer heat and eliminating dampness and calming and refreshing are better, the proportion of the medicinal materials is reasonable, and the mosquito-repellent effect of the traditional Chinese medicine composition is better.
In this embodiment, the Chinese medicinal composition further includes, in parts by weight: 20-30 parts of honeysuckle, 10-20 parts of cacumen biotae and 5-15 parts of folium artemisiae argyi.
The honeysuckle flower, sweet and cold, entering lung, stomach and heart channels, has the effects of clearing away heat and toxic materials and dispelling wind and heat, also has stronger anti-pathogenic microorganism effects, and has inhibitory effects on various pathogenic bacteria such as staphylococcus aureus, hemolytic streptococcus, escherichia coli, dysentery bacillus, typhoid bacillus and the like. The cacumen biotae is cold in nature, bitter and astringent in taste, enters lung channels, liver channels and spleen channels, has the effects of cooling blood, stopping bleeding, reducing phlegm and relieving cough, contains volatile substances with special fragrance, and has the effect of repelling mosquitoes. Folium Artemisiae Argyi contains volatile oil, and has effects of warming channels, stopping bleeding, dispelling cold, and relieving pain.
The honeysuckle, the perilla leaves, the clove, the elsholtzia and the agastache are matched for use, so that the effects of resisting bacteria, dispelling summer heat, eliminating dampness, inducing sweat and relieving exterior syndrome can be further improved, and the effects of repelling mosquitoes can be further improved by matching the cacumen biotae, the amomum cardamomum, the dried orange peel, the rosemary and the fennel. The folium artemisiae argyi, the lavender, the lemon grass, the pepper and the rhizoma acori graminei are matched for use, so that the effects of clearing heat and dispelling cold and calming the nerves and restoring consciousness can be further improved. The combination of the traditional Chinese medicine composition and the traditional Chinese medicine composition can ensure that the mosquito-repellent effect and the antibacterial effect of the traditional Chinese medicine composition are better.
A preparation method of a traditional Chinese medicine composition for repelling mosquitoes comprises the following steps:
aging the raw materials at 70-80 deg.C for 5-10min, and pulverizing to particle size less than 1mm to obtain powder.
Through curing the raw materials, the medicine properties of the medicinal materials are milder, the water content of the medicinal materials is reduced, the deterioration of the medicinal materials is avoided, and the service time of the traditional Chinese medicine composition is prolonged. When the raw materials are cured at 70-80 deg.C for 5-10min, the medicinal properties are optimal, and the application time is longest. Through crushing, volatile substances of the medicinal materials are better volatilized, the concentration of the volatile substances in the air is improved, and the mosquito repelling effect of the traditional Chinese medicine composition is better. Meanwhile, the medicinal materials do not need to be directly contacted with the skin, so that the safety of the traditional Chinese medicine composition in use is improved, almost no side effect exists, and meanwhile, the medicinal materials are all natural components, so that the possibility of forming drug resistance is low. When the particle size is less than 1mm, the volatile substances in the medicinal materials have the best volatilization effect.
In the embodiment, the powder is further bagged, and each bag is 20-30g to prepare the sachet.
The traditional Chinese medicine composition is prepared into the sachet, the method is simple and rapid, the sachet can be prepared by local materials, the use is convenient, the sachet is suitable for large-scale production, the active ingredients of the medicinal materials are not lost, the fragrance of the medicinal materials is naturally diffused, and the mosquito repelling effect can be further enhanced. After the mosquito repellent is used, the replacement is convenient, the residual medicinal materials can be recycled to be made into balm or mosquito repellent liquid, the utilization rate of the medicinal materials can be further improved, and the waste of the medicinal materials is avoided.
Also comprises adding ethanol into the powder, performing microwave extraction for 30-50min, concentrating the extractive solution, and solidifying. The mass ratio of the ethanol to the powder is (2-5): 1. concentrating to obtain extract with relative density of 1-1.25. Curing at 1-5 deg.C for 10-15 min.
The effective components in the medicinal materials can be separated out by extracting the powder with ethanol, and the effective components in the medicinal materials can be dissolved out to the maximum extent by adopting microwave extraction for 30-50 min. Wherein, the mass ratio of ethanol to powder is (2-5): when 1, the effect of precipitating the active ingredient is best. Concentration can further improve the concentration of effective components, so that the mosquito and insect repelling effect is better. After being cured, the coating is more convenient to carry and use.
After concentrating and before solidifying, heating and melting natural beeswax to obtain a solution, adding the extract into the solution, and stirring and mixing for 5-10 min. The mass ratio of the natural beewax to the extract is (0.1-1.5) to 1.
The natural beeswax is used as a curing agent for curing, so that the operation is simple and the curing time is short. The hardness of the ointment is more suitable for use under the condition of the proportion of the natural beewax and the extract. When the ointment is used, the volatile substances of the ointment can be used for repelling mosquitoes, and the ointment can also be smeared on clothes or skin to achieve the effect of repelling mosquitoes. The paste prepared by the method can increase the using method of the traditional Chinese medicine composition, and is more convenient to use in different environments or under different conditions.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A traditional Chinese medicine composition for repelling mosquitoes comprises the following raw materials: 50g of perilla leaf, 50g of elsholtzia, 50g of mint, 40g of wrinkled gianthyssop herb, 40g of round cardamom fruit, 30g of lavender, 10g of dried orange peel, 20g of rosemary, 20g of fennel, 50g of lemon grass, 10g of clove, 10g of pepper and 10g of grassleaf sweelflag rhizome.
A preparation method of a traditional Chinese medicine composition for repelling mosquitoes comprises the following steps:
aging at 75 deg.C for 8min, pulverizing to particle size less than 1mm to obtain powder, and bagging the powder with 25g per bag to obtain sachet.
Example 2
A traditional Chinese medicine composition for repelling mosquitoes comprises the following raw materials: 40g of perilla leaf, 45g of elsholtzia, 45g of mint, 35g of wrinkled gianthyssop herb, 35g of amomum cardamomum, 25g of lavender, 5g of dried orange peel, 15g of rosemary, 15g of fennel, 45g of lemon grass, 10g of clove, 5g of pepper and 5g of grassleaf sweelflag rhizome.
A preparation method of a traditional Chinese medicine composition for repelling mosquitoes comprises the following steps:
aging at 70 deg.C for 5min, pulverizing to particle size less than 1mm to obtain powder, adding ethanol into the powder, microwave extracting for 30min, concentrating the extractive solution, and solidifying. The mass ratio of ethanol to powder is 2: 1.
example 3
A traditional Chinese medicine composition for repelling mosquitoes comprises the following raw materials: 60g of perilla leaf, 55g of elsholtzia, 58g of mint, 50g of wrinkled gianthyssop herb, 45g of amomum cardamomum, 35g of lavender, 15g of dried orange peel, 30g of rosemary, 25g of fennel, 60g of lemon grass, 20g of clove, 20g of pepper and 15g of grassleaf sweelflag rhizome.
A preparation method of a traditional Chinese medicine composition for repelling mosquitoes comprises the following steps:
aging at 80 deg.C for 10min, pulverizing to particle size less than 1mm to obtain powder, adding ethanol into the powder, microwave extracting for 50min, concentrating the extractive solution, and solidifying. The mass ratio of ethanol to powder is 5: 1.
example 4
A traditional Chinese medicine composition for repelling mosquitoes comprises the following raw materials: 50g of perilla leaf, 50g of elsholtzia, 50g of mint, 40g of wrinkled gianthyssop herb, 40g of round cardamom fruit, 30g of lavender, 10g of dried orange peel, 20g of rosemary, 20g of fennel, 50g of lemon grass, 10g of clove, 10g of pepper and 10g of grassleaf sweelflag rhizome.
A preparation method of a traditional Chinese medicine composition for repelling mosquitoes comprises the following steps:
aging at 75 deg.C for 8min, pulverizing to particle size less than 1mm to obtain powder, adding ethanol into the powder, microwave extracting for 40min, concentrating the extractive solution, and solidifying. The mass ratio of ethanol to powder is 3: 1.
example 5
A traditional Chinese medicine composition for repelling mosquitoes comprises the following raw materials: 45g of perilla leaf, 52g of elsholtzia, 48g of mint, 45g of wrinkled gianthyssop herb, 38g of amomum cardamomum, 27g of lavender, 9g of dried orange peel, 22g of rosemary, 23g of fennel, 55g of lemon grass, 14g of clove, 14g of pepper, 7g of rhizoma acori graminei, 20g of honeysuckle, 10g of cacumen biotae and 5g of folium artemisiae argyi.
A preparation method of a traditional Chinese medicine composition for repelling mosquitoes comprises the following steps:
aging the raw materials at 72 deg.C for 7min, pulverizing to particle size less than 1mm to obtain powder, adding ethanol into the powder, microwave extracting for 35min, concentrating the extractive solution to obtain extract with relative density of 1.1, and solidifying the extract at 1 deg.C for 10 min. Wherein the mass ratio of the ethanol to the powder is 4: 1.
example 6
A traditional Chinese medicine composition for repelling mosquitoes comprises the following raw materials: 45g of perilla leaf, 52g of elsholtzia, 48g of mint, 45g of wrinkled gianthyssop herb, 38g of amomum cardamomum, 27g of lavender, 9g of dried orange peel, 22g of rosemary, 23g of fennel, 55g of lemon grass, 14g of clove, 14g of pepper, 7g of rhizoma acori graminei, 30g of honeysuckle, 20g of cacumen biotae and 15g of folium artemisiae argyi.
A preparation method of a traditional Chinese medicine composition for repelling mosquitoes comprises the following steps:
aging the raw materials at 72 deg.C for 7min, pulverizing to particle size less than 1mm to obtain powder, adding ethanol into the powder, microwave extracting for 35min, concentrating the extractive solution to obtain extract with relative density of 1.1, heating natural Cera flava to melt to obtain solution, adding the extract into the solution, stirring and mixing for 8min, and curing at 5 deg.C for 15 min. Wherein the mass ratio of the ethanol to the powder is 4: 1, the mass ratio of the natural beewax to the extract is 0.1: 1.
Example 7
The difference between the example and the example 1 is that 30g of honeysuckle, 20g of cacumen biotae and 15g of folium artemisiae argyi are added to the raw materials, and the rest is the same as the example 1.
Results of the experiment
1. Component detection
The contents of menthol, safrole, anethole and anisaldehyde in the paste of the embodiments 2 to 6 of the invention are detected by High Performance Liquid Chromatography (HPLC), and the specific results are as follows:
TABLE 1 paste ingredient test results
As can be seen from table 1, the pastes of examples 2 to 6 of the present invention all contained menthol, safrole, anethole and anisaldehyde, and the content of each ingredient was the largest in example 6. In examples 2 to 4, the raw materials and the paste were prepared in the same steps but with different amounts of the raw materials and different operating conditions, and it was found that the paste had a higher content of the active ingredient in the raw materials and operating conditions of example 4. In contrast, in example 6, the content of each active ingredient was the highest, i.e., the extraction rate of the active ingredient was the best, in the preparation steps and the preparation conditions of example 6, compared with examples 2 to 5.
2. Clinical trial
70 subjects were selected and randomized into 7 groups of 10 subjects each. Groups 1-7 correspond to the mosquito repellent prepared using examples 1-7 of the present invention. Wherein 1 group and 7 groups respectively wear the sachet on the body, and 2-6 groups respectively carry the ointment on the body, and keep the ointment to be volatilized freely in the air. 1-7 groups of testers wait for 1 hour in places with more mosquito accumulation respectively, and the mosquito prevention effect of the testers is investigated after 1 hour, and the investigation result is as follows:
TABLE 2 mosquito test results
The effect is shown: mosquitoes hardly have the biting condition; the method has the following advantages: mosquitoes have a few bites; and (4) invalidation: mosquitoes bite normally.
As can be seen from Table 2, the sachets or pastes prepared in the embodiments 1-7 of the invention have good anti-mosquito effect. Example 1 compared with example 7, the addition of honeysuckle, cacumen biotae and folium artemisiae argyi can improve the mosquito-repellent effect of the sachet. Example 6 compared with example 7, the traditional Chinese medicine composition has better mosquito-repellent effect after being prepared into paste. Example 6 compared with examples 2 to 5, the addition of raw materials and the addition of preparation steps can further improve the anti-mosquito effect.
In conclusion, the traditional Chinese medicine composition for repelling mosquitoes in the embodiment of the invention has good mosquito repelling effect, no side effect and low possibility of forming drug resistance. According to the preparation method disclosed by the invention, through curing the raw materials, the medicinal properties of the medicinal materials are milder, the water content of the medicinal materials is reduced, the medicinal materials are prevented from going bad, and the service life of the traditional Chinese medicine composition is prolonged. Through crushing, volatile substances of the medicinal materials are better volatilized, the concentration of the volatile substances in the air is improved, and the mosquito repelling effect of the traditional Chinese medicine composition is better. Meanwhile, the medicinal materials do not need to be directly contacted with the skin, so that the safety of the traditional Chinese medicine composition in use is improved, almost no side effect exists, and meanwhile, the medicinal materials are all natural components, so that the possibility of forming drug resistance is low.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for repelling mosquitoes is characterized by comprising the following raw materials in parts by weight: 40-60 parts of perilla leaf, 45-55 parts of elsholtzia, 45-58 parts of mint, 35-50 parts of wrinkled gianthyssop herb, 35-45 parts of round cardamom, 25-35 parts of lavender, 5-15 parts of dried orange peel, 15-30 parts of rosemary, 15-25 parts of fennel, 45-60 parts of lemon grass, 10-20 parts of clove, 5-20 parts of pepper and 5-15 parts of grassleaf sweelflag rhizome.
2. The traditional Chinese medicine composition for repelling mosquitoes as claimed in claim 1, further comprising, in parts by weight: 20-30 parts of honeysuckle, 10-20 parts of cacumen biotae and 5-15 parts of folium artemisiae argyi.
3. A method for preparing the traditional Chinese medicine composition for repelling mosquitoes as claimed in claim 2, which comprises the following steps: aging the raw materials at 70-80 deg.C for 5-10min, and pulverizing to particle size less than 1mm to obtain powder.
4. The method of claim 3, further comprising bagging the powder in 20-30g bags to form sachets.
5. The preparation method according to claim 3, further comprising adding ethanol to the powder, performing microwave extraction for 30-50min, and concentrating and solidifying the extract.
6. The production method according to claim 5, wherein the mass ratio of the ethanol to the powder is (2-5): 1.
7. the process according to claim 5, wherein the concentration is carried out to obtain an extract having a relative density of 1 to 1.25.
8. The method according to claim 5, wherein the curing is carried out at 1 to 5 ℃ for 10 to 15 min.
9. The preparation method according to claim 5, further comprising heating and melting natural beeswax to obtain a solution after concentrating and before solidifying, adding the extract into the solution, and stirring and mixing for 5-10 min.
10. The preparation method according to claim 9, wherein the mass ratio of the natural beeswax to the extract is (0.1-1.5): 1.
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| CN116036184A (en) * | 2023-01-12 | 2023-05-02 | 广东药科大学 | Traditional Chinese medicine mosquito-repellent pharmaceutical composition and extraction method and application thereof |
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