CN104839246A - Bacteriostatic disinfection liquid for clinical laboratory and preparation method thereof - Google Patents
Bacteriostatic disinfection liquid for clinical laboratory and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a bacteriostatic disinfection liquid for a clinical laboratory, wherein the bacteriostatic disinfection liquid is prepared by taking the following main raw materials by weight: 15-25 parts of white sandalwood, 10-20 parts of ligusticum chuanxiong, 4-12 parts of mint, 1-5 parts of Chinese prickly ash, 1-5 parts of cortex pseudolaricis, 10-20 parts of lavender, 5-9 parts of taxus chinensis, 3-8 parts of honeysuckle, 1-5 parts of purple perilla, 2-6 parts of lemongrass, 2-6 parts of flores chamomillae, 10-20 parts of lophatherum gracile, 6-12 parts of cortex moutan, 5-10 parts of folium artemisiae argyi, and 5-15 parts of artemisia apiacea. The bacteriostatic disinfection liquid has the characteristics of being simple in preparation method, convenient to use, convenient to carry and suitable for ward internal sterilization disinfection, has the efficacies of bacteriostasis, disinfection, heat clearing and lung moistening, takes local relatively common traditional Chinese medicinal materials as raw materials, and is low in cost.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of clinical laboratory antibacterial thimerosal and preparation method.
Background technology
Clinical laboratory is the bridge between clinical medicine and preclinical medicine, comprises the subdisciplines such as clinical chemistry, clinical microbiology, clinical immunology, hematology, osology and transfusion science.At present, inspection and the test of Klebsiella Pneumoniae (ATCC700603) and Neisseria gonorrhoeae (ATCC49226) is being carried out in control laboratory, because these two kinds of germs all have stronger contagiosity, if do not notice that the position such as hand easily via operator is transmitted, thus damage.
In prior art, the sterilization sterilizing in space in clinical laboratory ward, conventional method has chemical reagent sterilizing, ray sterilizing, hot air sterilization, warm sterilizing and filtration sterilization and germ killing drugs suffocating sterilization.Several mode is mainly used in public place and specific place above, and last a kind of mode then both can be used for public place, also can enter daily common people family.Along with the quality of the life of people is more and more higher, the requirement of people to domestic environment also progressively improves, general thimerosal can only play the effect purified air, and the effect do not possessed body-care, people can not be beneficial to health after breathing, along with going from bad to worse of present air quality, the requirement of people to air quality is more and more higher.Chinese patent (number of patent application is 200710157628.2) " a kind of for preventing thimerosal and the preparation technology thereof of influenza ", relate to and a kind ofly carried out medicine treated and prevent and preparation method thereof by fume smoking method, also can be used for the prevention of other lung heart and disease of immune system; It is mainly that mixed raw material becomes by the bulb of fritillary, calamus, rattletop, Golden Larch Bark, ramulus mori, almond, and the parts by weight of traditional Chinese medicine amounts of components used are: bulb of fritillary 1-4 part, calamus 3-7 part, rattletop 1-2 part, Golden Larch Bark 1-2 part, ramulus mori 2-6 part, almond 2-6 part; The object of this invention is to propose a kind of new medication, can not bring again painful uncomfortable simultaneously.And for example Chinese patent (number of patent application is 200310121763.3) " Chinese medicine cold-preventing germicidal thimerosal and thimerosal stove ", this thimerosal is that main component is equipped with eight Chinese medicine compositions such as rhizome of cyrtomium, wrinkled giant hyssop, calamus, frankincense, rhizoma atractylodis, peppermint and golden cypress with wormwood; Be used from the beginning of, seasonal febrile diseases popular in epidemic disease that the room hall purifies air, fragrant odour, property of medicine gas has significant sterilizing to suppress the effect of virus, focuses on preventing cold and upper respiratory infectious disease, produces refreshing effect to the mind, sterilizing sterilization is better than ultraviolet bactericidal action.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of clinical laboratory antibacterial thimerosal, there is sterilization, antibacterial effect, medicinal material medicine source of the present invention is easy to get, with low cost, selected medicinal material mostly be mild in medicine property and thing, convenient nursing personnel are to sterilization in clinical laboratory ward, and effect is lasting, does not have irritant smell, to human body without any injury.
Another object of the present invention is just to provide the preparation method of above-mentioned thimerosal.
Technical scheme of the present invention is:
The antibacterial thimerosal of clinical laboratory, takes off the primary raw material stating weight proportion and is prepared from:
Santalum album 15-25 part Ligusticum wallichii 10-20 part peppermint 4-12 part
Chinese prickly ash 1-5 part Golden Larch Bark 1-5 part lavender 10-20 part
Chinese yew 5-9 part honeysuckle 3-8 part purple perilla 1-5 part
Lemon-grass 2-6 part chamomile 2-6 part lophatherum gracile 10-20 part
Moutan bark 6-12 part tarragon 5-10 part sweet wormwood 5-15 part.
The antibacterial thimerosal of clinical laboratory, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from:
Santalum album 18-23 part Ligusticum wallichii 13-18 part peppermint 6-10 part
Chinese prickly ash 2-4 part Golden Larch Bark 2-4 part lavender 13-18 part
Chinese yew 6-8 part honeysuckle 5-7 part purple perilla 2-4 part
Lemon-grass 3-5 part chamomile 3-5 part lophatherum gracile 13-18 part
Moutan bark 8-10 part tarragon 6-9 part sweet wormwood 8-13 part.
The antibacterial thimerosal of clinical laboratory, more preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from:
Santalum album 20 parts of Ligusticum wallichiis 15 portions of peppermints 8 parts
Chinese prickly ash 3 parts of Golden Larch Barks 3 portions of lavenders 15 parts
Chinese yew 7 portions of honeysuckles 6 parts of purple perillas 3 parts
Lemon-grass 4 parts of chamomiles 4 portions of lophatherum graciles 15 parts
Moutan bark 9 portions of tarragons 8 portions of sweet wormwoods 10 parts.
The preparation method of above-mentioned thimerosal, step is as follows:
(1) Ligusticum wallichii, peppermint, Chinese prickly ash, Golden Larch Bark, tarragon and sweet wormwood are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 3-7 days, filter, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1-2 hour, volatile oil and water are together distilled, collect distillate, leave standstill 50-70 minute, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) Santalum album, lavender, Chinese yew, lemon-grass and chamomile is even with yellow rice wine spray, be placed on tile, little fire dries 10-20 minute slowly, cools and grinds to form smalls, crosses 80-120 mesh sieve;
(3) honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 30-40 DEG C, soak 20-40 minute, be heated to boiling, continue to filter after 20-40 minute, gained concentrating filter liquor obtains concentrate to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrate are mixed, fully stir into thick paste; Be placed in container by thick paste and dry 40-60 minute, obtain drying object, dry at temperature is 70-80 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
The preparation method of above-mentioned thimerosal, step (1) sealing is placed in shady and cool ventilation place and leaves standstill 4-6 days (preferred, sealing is placed in shady and cool ventilation place and leaves standstill 5 days).
The preparation method of above-mentioned thimerosal, step (1) filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.3-1.8 hour (preferred, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.5 hours).
The preparation method of above-mentioned thimerosal, step (2) little fire dries 13-18 minute (preferred, little fire dries 15 minutes slowly) slowly.
The preparation method of above-mentioned thimerosal, honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 33-38 DEG C by step (3), soak 25-35 minute (preferred, honeysuckle, purple perilla, lophatherum gracile and moutan bark to be added the warm water of 35 DEG C, soak 30 minutes).
The preparation method of above-mentioned thimerosal, step (3) is heated to boiling, continues to filter after 25-35 minute (preferred, to be heated to boiling, to continue to filter after 30 minutes).
The preparation method of above-mentioned thimerosal, thick paste is placed in container by step (4) dries 45-55 minute, obtains drying object, dry at temperature is 73-78 DEG C (preferred, thick paste is placed in container and dries 50 minutes, obtain drying object, dry at temperature is 75 DEG C).
Best using method: be the result for the treatment of making the present invention reach best, the thimerosal made, every day, get 40-60ml, be placed on heating plate, with alcolhol burner heating, being sprayed in clinical laboratory ward or being sprayed at clinical laboratory medical personnel all can have light delicate fragrance in one day with it, and fungistatic effect is fabulous.
The pharmacological effect of each bulk drug is respectively:
Santalum album: santal is the pith part taking from sandalwood, the spices refined.During independent burning, smell is usually not good, if but mix with other spices, then can " to high point on the thing drawing fragrance.Because it enjoys Buddhist to praise highly with the mellow taste of dense history breath.Be described as " king of spices ".Santalum album also has medical value, can control pyreticosis.If external application for curing, can anti-inflammatory go to swell, conditioning skin quality.Delaying senility, is that Ancient Times in China treats dermopathic main Chinese medicinal materials period.
Ligusticum wallichii: the in vitro test Ligusticum wallichiis such as antibacterial action have inhibitory action to large intestine, dysentery, distortion, green pus, typhoid fever, paratyphosum Bacterium and comma bacillus etc.Ligusticum wallichii water logging agent (1:3) also has inhibitory action to some pathogenic dermatophyte in vitro.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, hypochondriac pain abdomen ache, arthritis muscle contraction, through closing, difficult labour, postpartum stasis blocking block pain, ulcer sores.For irregular menstruation, through closing dysmenorrhoea, lump in the abdomen is suffered from abdominal pain, the shouting pain of the chest side of body, tumbling and swelling, headache, arthralgia due to wind-dampness.
Peppermint: be a kind of fragrant crop having extraordinary economic worth.It is sweating antipyretic medicine, controls influenza, the disease such as headache, hot eyes, body heat, throat, gum swell and ache.
Chinese prickly ash: return spleen, stomach, kidney channel.Effect warming middle energizer to relieve pain, killing parasites to relieve itshing.Cure mainly for coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to enterositosis; External application: eczema, pruritus vulvae.
Golden Larch Bark: the organic acid of Golden Larch Bark, ethanol extract and benzene medicinal extract, the 10 kind pathomycetes common to China all have certain antibacterial action.Its consumption 0.1-1mg/ml, is namely had bactericidal action to permitting blue achorion, acrothesium floccosum, rust little gemma tinea bacterium, Microsporum gypseum and Candida albicans.Antibacterial action is the strongest with organic acid, and ethanol extract takes second place, and benzene medicinal extract again.
Moutan bark: bitter, pungent, is slightly cold, the thoughts of returning home, liver, kidney channel, has clearing heat and cooling blood, activates blood circulation and disperses blood clots, the effect such as reducing the asthenic fever, and thermal man's ying blood, febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, through closing dysmenorrhoea, falling and flutterring the pain of injury, carbuncle sore tumefacting virus.
Lavender: Lavender is the complex mixture of many dissimilar aromatic compounds composition, 30 Multiple components, main component linalool, bergamio, cineole, B-Luo Qin alkene (comprise cis and trans) to, acetic acid lavender ester, lavender alcohol, terpene-4-alcohol and camphor etc. 122182.Lavender has the activity of opposing various bacteria, and linalool is the antibacterial main component of Lavender, and it can suppress the growth of 17 kinds of bacteriums (comprising gram positive bacteria and gram-negative bacteria), 10 kinds of fungies.
Chinese yew: its extract of the main body of the medical value-secondary metabolism derivative-taxol of Chinese yew.Taxol is the antitumor activity composition separated from the bark of yewtree the earliest.Be one of best medicine for the treatment of Metastatic carcinoma in the ovary and breast cancer, also have lung cancer, cancer of the esophagus simultaneously and show curative effect, have obvious suppression to ephritis and parvovirus inflammation.The root of Chinese yew, stem, leaf can be used as medicine, can treat urine smooth, eliminate and swell and ache, for: diabetes, female irregular menstruation, blood volume increase have therapeutic action.Chinese yew also may be used for postpartum recuperating, has certain therapeutic action to women's illness.
Honeysuckle: honeysuckle is described as clearing heat and detoxicating good medicine from ancient times.Its property sweet cold air fragrance, clear heat with drugs of sweet flavour and cold nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison, and for various febrile disease, as the disease such as body heat, dermexanthesis, spot, hot carbuncle carbuncle, abscess of throat, equal Be very effective, its effect is mainly clearing heat and detoxicating, cures mainly warm disease heating, toxic-heat and blood stasis, ulcer serious case of furuncle etc.Modern study proves, honeysuckle contains the pharmacological component such as chlorogenic acid, cyanidenon glycosides, stronger restraint is had to various pathogens and infection of the upper respiratory tract Causative virus etc. such as hemolytic streptococcus, tuberculosis stalk bacterium, in addition also can develop immunitypty, Robust speaker feature, protect liver, antitumor, anti-inflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary, hypertension etc. more than 40 with other medicines compatibility and plant illness.
Purple perilla: purple perilla can Pulvis Diaphoreticus cold with heresy of inducing sweat, again can promoting the circulation of qi wide in, separate strongly fragrant preventing or arresting vomiting, therefore doublely to chill table disease see symptoms of emesis uncomfortable in chest, use this product, be very suitable; Or the smooth symptom of the stagnation of the circulation of vital energy is had without table disease, also can be used for a surname logical.As join wrinkled giant hyssop, dried orange peel then induce sweat and in, join the tuber of pinellia, the bark of official magnolia and then separate strongly fragrant wide chest.For cold: purple perilla can fall apart exterior cold, sweating power is comparatively strong, for chill table disease, seeing aversion to cold, heating, the disease such as lossless, often joining ginger with using; Having the stagnation of the circulation of vital energy concurrently as shown disease, having to be equal to rhizoma cyperi, dried orange peel and using.For uncomfortable in chest, the diseases such as evil of vomitting: purple perilla is used for the taste stagnation of the circulation of vital energy, uncomfortable in chest, evils of vomitting, no matter with or without table disease, all can apply, be all get its promoting the circulation of qi wide in effect, clinical often and wrinkled giant hyssop compatibility apply.
Lemon-grass: for contracting wine, offer a sacrifice to gods or ancestors world ancestors, the Chu Guozhu Zhou Dynasty wraps Mao Zhigong, offers give all emperors with lemon-grass.Utilize part: blade is main, refinement essential oil then leaf sheath also can utilize.Lemon-grass be growth at semi-tropical a kind of cogongrass spices, natural in citrus scented, have and effect that stomach ventilation, restoring consciouness are promoted the sexual maturity.
Tarragon: warming channel for arresting bleeding, eliminating cold to stop pain; External application removing dampness to stop itchin.Cure mainly for spitting blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, menorrhalgia, blood under threatened abortion, few abdomen crymodynia, through cold uncomfortable, palace is cold infertile; Control pruitus outward.Vinegar Chinese mugwort charcoal warming channel for arresting bleeding is hemorrhage for deficient cold type.
Chamomile: chamomile essential oil is also popular health protection and pharmaceutical preparation.Effect of the helpful sleep of chamomile, alleviates inflammation and the pain symptom of patient, alleviates the insomnia caused by neurotic skin itch.Also there is a large amount of cultivation in China, in order to be used as medicine and tea making.The effect of chamomile and effect: mildly bitter flavor, Gan Xiang, improving eyesight, move back irascibility, Cure for insomnia, reduces blood pressure, can invigorate, refresh oneself.Strengthen memory, reduce cholesterol.Expelling phlegm and arresting coughing, can effectively alleviate bronchitis and asthma, the courbature that can releive headache, antimigraine or flu cause, in and hydrochloric acid in gastric juice, calm nerves helpful.Can eliminate the Ji Rou Acid pain caused by flu, can calm spirit, slow mood of relaxing, promote sleep quality, also can improve irritated skin.Helpful sleep, moist skin, prolonged constipation can be controlled, can eliminate anxiety, eye fatigue, moistening lung, health, and the indigestion that anxiety causes with anxiety can be treated, and to having a sleepless night, neuralgia and cramp, enterogastritis benefits all to some extent, alleviates headache.Chamomile tea hot drink also has good effect to flu! When mouthwash can alleviate toothache; Add in shampoo and can be hair and increase beautiful gloss; Loosen uneasy body and mind, drink in insomnia or the normal evening sending out nightmare, beyond thought side can be had to help ﹗, and it can also alleviate eye fatigue, and the cold tea bag brewed is applied eyes, more can help to remove dark eye circles.
Lophatherum gracile: lophatherum gracile has effect of clearing heat and relieving fidgetness, diuresis, be mainly used in treating in the heart disease heat, cough with dyspnea, haematemesis, hot malicious wind, only quench one's thirst, press borax poison, dissolving phlegm, control fanatical unhappiness, apoplectic aphasia in silence, pain head wind, only palpitation with fear, pestilence fan be vexed, kill small worm, heat extraction delays the diseases such as spleen.
Sweet wormwood: sweet wormwood decocting liquid has stronger bacteriostasis to Staphylococcus epidermidis, micrococcus catarrhalis, bacillus anthracis, diphtheria bacillus, also has certain inhibitory action to staphylococcus aureus, Pseudomonas aeruginosa, shigella dysenteriae, tuberculosis stalk bacterium etc.Sweet wormwood volatile oil, when 0.25% concentration, has bacteriostasis to all dermatophytes, when 1% concentration, has bactericidal action to all dermatophytes.Sweet wormwood have the effect of resisiting influenza virus.Sodium artesunate is to golden grape, shigella flexneri, bacillus anthracis, micrococcus catarrhalis, and A type and paratyphoid B stalk bacterium all have certain antibacterial action.Sitosterol in sweet wormwood and stigmasterol also have antivirus action.
Thimerosal of the present invention " more holistic ", both can to ward sterilization, can sterilize again, most importantly can breed by Antifungi, this is the large feature being different from pharmacotherapy, bulk drug of the present invention, to have antibacterial, antimycotic, sterilization, clearing lung-heat dispel hot merit effect drug regimen together, be prepared into thimerosal, and this thimerosal is prepared from according to traditional Chinese medicine principle completely, more safe and reliable, without any side effects, to skin without any stimulation, it can adopt water to heat or the mode of alcohol heating heats rear sprinkling, can be scentetd and improve IAQ in air, reduce some harmful substances in air, in addition, some such as can improve body immunity, antitumor, cancer-resisting, suppression virus, flu-prevention and upper respiratory disease, clearing heat and detoxicating, dampness elimination and in and the beneficiating ingredient such as protection cardiovascular system can enter oxygen diffusion, play antitumor, cancer-resisting and health-care effect preferably.
Embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the antibacterial thimerosal of clinical laboratory, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part):
Santalum album 15 parts of Ligusticum wallichiis 10 portions of peppermints 4 parts
Chinese prickly ash 1 part of Golden Larch Bark 1 portion of lavender 10 parts
Chinese yew 5 portions of honeysuckles 3 parts of purple perillas 1 part
Lemon-grass 2 parts of chamomiles 2 portions of lophatherum graciles 10 parts
Moutan bark 6 portions of tarragons 5 portions of sweet wormwoods 5 parts.
The preparation method of above-mentioned thimerosal, preparation process is as follows:
(1) Ligusticum wallichii, peppermint, Chinese prickly ash, Golden Larch Bark, tarragon and sweet wormwood are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 3 days, filter, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1 hour, volatile oil and water are together distilled, collect distillate, leave standstill 50 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) Santalum album, lavender, Chinese yew, lemon-grass and chamomile is even with yellow rice wine spray, be placed on tile, little fire dries 10-20 minute slowly, cools and grinds to form smalls, crosses 80 mesh sieves;
(3) honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 30 DEG C, soak 20 minutes, be heated to boiling, continue to filter after 20 minutes, gained concentrating filter liquor obtains concentrate to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrate are mixed, fully stir into thick paste; Be placed in by thick paste in container and dry 40 minutes, obtain drying object, dry at temperature is 70 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
embodiment 2the antibacterial thimerosal of clinical laboratory, takes off the primary raw material stating weight proportion and is prepared from (getting 5g for every part):
Santalum album 25 parts of Ligusticum wallichiis 20 portions of peppermints 12 parts
Chinese prickly ash 5 parts of Golden Larch Barks 5 portions of lavenders 20 parts
Chinese yew 9 portions of honeysuckles 8 parts of purple perillas 5 parts
Lemon-grass 6 parts of chamomiles 6 portions of lophatherum graciles 20 parts
Moutan bark 12 portions of tarragons 10 portions of sweet wormwoods 15 parts.
The preparation method of above-mentioned thimerosal, preparation process is as follows:
(1) Ligusticum wallichii, peppermint, Chinese prickly ash, Golden Larch Bark, tarragon and sweet wormwood are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 7 days, filter, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 2 hours, volatile oil and water are together distilled, collect distillate, leave standstill 70 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) Santalum album, lavender, Chinese yew, lemon-grass and chamomile is even with yellow rice wine spray, be placed on tile, little fire dries 20 minutes slowly, cools and grinds to form smalls, crosses 120 mesh sieves;
(3) honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 40 DEG C, soak 40 minutes, be heated to boiling, continue to filter after 40 minutes, gained concentrating filter liquor obtains concentrate to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrate are mixed, fully stir into thick paste; Be placed in by thick paste in container and dry 60 minutes, obtain drying object, dry at temperature is 80 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
embodiment 3the antibacterial thimerosal of clinical laboratory, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part):
Santalum album 18 parts of Ligusticum wallichiis 13 portions of peppermints 6 parts
Chinese prickly ash 2 parts of Golden Larch Barks 2 portions of lavenders 13 parts
Chinese yew 6 portions of honeysuckles 5 parts of purple perillas 2 parts
Lemon-grass 3 parts of chamomiles 3 portions of lophatherum graciles 13 parts
Moutan bark 8 portions of tarragons 6 portions of sweet wormwoods 8 parts.
The preparation method of above-mentioned thimerosal, preparation process is as follows:
(1) Ligusticum wallichii, peppermint, Chinese prickly ash, Golden Larch Bark, tarragon and sweet wormwood are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 4 days, filter, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.3 hours, volatile oil and water are together distilled, collect distillate, leave standstill 55 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) Santalum album, lavender, Chinese yew, lemon-grass and chamomile is even with yellow rice wine spray, be placed on tile, little fire dries 13 minutes slowly, cools and grinds to form smalls, crosses 90 mesh sieves;
(3) honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 33 DEG C, soak 25 minutes, be heated to boiling, continue to filter after 25 minutes, gained concentrating filter liquor obtains concentrate to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrate are mixed, fully stir into thick paste; Be placed in by thick paste in container and dry 45 minutes, obtain drying object, dry at temperature is 73 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
embodiment 4the antibacterial thimerosal of clinical laboratory, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part):
Santalum album 23 parts of Ligusticum wallichiis 18 portions of peppermints 10 parts
Chinese prickly ash 4 parts of Golden Larch Barks 4 portions of lavenders 18 parts
Chinese yew 8 portions of honeysuckles 7 parts of purple perillas 4 parts
Lemon-grass 5 parts of chamomiles 5 portions of lophatherum graciles 18 parts
Moutan bark 10 portions of tarragons 9 portions of sweet wormwoods 13 parts.
The preparation method of above-mentioned thimerosal, preparation process is as follows:
(1) Ligusticum wallichii, peppermint, Chinese prickly ash, Golden Larch Bark, tarragon and sweet wormwood are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 6 days, filter, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.8 hours, volatile oil and water are together distilled, collect distillate, leave standstill 65 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) Santalum album, lavender, Chinese yew, lemon-grass and chamomile is even with yellow rice wine spray, be placed on tile, little fire dries 18 minutes slowly, cools and grinds to form smalls, crosses 110 mesh sieves;
(3) honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 38 DEG C, soak 35 minutes, be heated to boiling, continue to filter after 35 minutes, gained concentrating filter liquor obtains concentrate to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrate are mixed, fully stir into thick paste; Be placed in by thick paste in container and dry 55 minutes, obtain drying object, dry at temperature is 78 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
embodiment 5the antibacterial thimerosal of clinical laboratory, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part):
Santalum album 20 parts of Ligusticum wallichiis 15 portions of peppermints 8 parts
Chinese prickly ash 3 parts of Golden Larch Barks 3 portions of lavenders 15 parts
Chinese yew 7 portions of honeysuckles 6 parts of purple perillas 3 parts
Lemon-grass 4 parts of chamomiles 4 portions of lophatherum graciles 15 parts
Moutan bark 9 portions of tarragons 8 portions of sweet wormwoods 10 parts.
The preparation method of above-mentioned thimerosal, preparation process is as follows:
(1) Ligusticum wallichii, peppermint, Chinese prickly ash, Golden Larch Bark, tarragon and sweet wormwood are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 5 days, filter, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.5 hours, volatile oil and water are together distilled, collect distillate, leave standstill 60 minutes, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) Santalum album, lavender, Chinese yew, lemon-grass and chamomile is even with yellow rice wine spray, be placed on tile, little fire dries 15 minutes slowly, cools and grinds to form smalls, crosses 100 mesh sieves;
(3) honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 35 DEG C, soak 30 minutes, be heated to boiling, continue to filter after 30 minutes, gained concentrating filter liquor obtains concentrate to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrate are mixed, fully stir into thick paste; Be placed in by thick paste in container and dry 50 minutes, obtain drying object, dry at temperature is 75 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
experimental example 1:the embodiment 5 gained clinical laboratory clinical practice of antibacterial thimerosal: with shigella dysenteriae, bacillus anthracis, tuberculosis stalk bacterium and Pseudomonas aeruginosa to the sterilization Simulation field test in clinical laboratory ward, get shigella dysenteriae, bacillus anthracis, tuberculosis stalk bacterium and Pseudomonas aeruginosa suspension respectively to drip and contaminate in the coating of polyfluortetraethylene pipe inside evenly, be placed in 37 DEG C of constant incubators dry, prepare bacterial carrier.Experimental group uses embodiment 5 products obtained therefrom, and control group uses other thimerosal.
With the product of gained of the present invention for bactericide, bactericidal effect result is as shown in table 1 below:
This thimerosal of table 1 is to the kill oncomelania of bacterium
Table 2 is other thimerosals kill oncomelania to bacterium
Result shows the kill oncomelania >5.89 of this product to the shigella dysenteriae contaminated on polyfluortetraethylene pipe, bacillus anthracis, tuberculosis stalk bacterium and Pseudomonas aeruginosa, shows that this product has good sterilization bactericidal effect.
The foregoing is only preferred embodiment of the present invention; not limit practical range of the present invention with this; those skilled in the art can without prejudice under spirit of the present invention and principle; make different changes and modification, but these change and modify and should be covered by within patent protection category that claims of the present invention defines.
Claims (10)
1. the antibacterial thimerosal of clinical laboratory, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
Santalum album 15-25 part Ligusticum wallichii 10-20 part peppermint 4-12 part
Chinese prickly ash 1-5 part Golden Larch Bark 1-5 part lavender 10-20 part
Chinese yew 5-9 part honeysuckle 3-8 part purple perilla 1-5 part
Lemon-grass 2-6 part chamomile 2-6 part lophatherum gracile 10-20 part
Moutan bark 6-12 part tarragon 5-10 part sweet wormwood 5-15 part.
2. the antibacterial thimerosal of clinical laboratory according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
Santalum album 18-23 part Ligusticum wallichii 13-18 part peppermint 6-10 part
Chinese prickly ash 2-4 part Golden Larch Bark 2-4 part lavender 13-18 part
Chinese yew 6-8 part honeysuckle 5-7 part purple perilla 2-4 part
Lemon-grass 3-5 part chamomile 3-5 part lophatherum gracile 13-18 part
Moutan bark 8-10 part tarragon 6-9 part sweet wormwood 8-13 part.
3. the antibacterial thimerosal of clinical laboratory according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from:
Santalum album 20 parts of Ligusticum wallichiis 15 portions of peppermints 8 parts
Chinese prickly ash 3 parts of Golden Larch Barks 3 portions of lavenders 15 parts
Chinese yew 7 portions of honeysuckles 6 parts of purple perillas 3 parts
Lemon-grass 4 parts of chamomiles 4 portions of lophatherum graciles 15 parts
Moutan bark 9 portions of tarragons 8 portions of sweet wormwoods 10 parts.
4. the preparation method of antibacterial thimerosal of the clinical laboratory according to any one of claim 1-3, is characterized in that: step is as follows:
(1) Ligusticum wallichii, peppermint, Chinese prickly ash, Golden Larch Bark, tarragon and sweet wormwood are smashed then add ethanol, sealing is placed in shady and cool ventilation place and leaves standstill 3-7 days, filter, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1-2 hour, volatile oil and water are together distilled, collect distillate, leave standstill 50-70 minute, distillate is cooled to room temperature, get upper strata fluid, obtain volatile oil stand-by;
(2) Santalum album, lavender, Chinese yew, lemon-grass and chamomile is even with yellow rice wine spray, be placed on tile, little fire dries 10-20 minute slowly, cools and grinds to form smalls, crosses 80-120 mesh sieve;
(3) honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 30-40 DEG C, soak 20-40 minute, be heated to boiling, continue to filter after 20-40 minute, gained concentrating filter liquor obtains concentrate to 1/2 of original volume;
(4) step (1) gained volatile oil and step (2) gained smalls and step (3) gained concentrate are mixed, fully stir into thick paste; Be placed in container by thick paste and dry 40-60 minute, obtain drying object, dry at temperature is 70-80 DEG C, a according to every 20g, add the distilled water of 100g, mixing is bottled and get final product.
5. the preparation method of thimerosal according to claim 4, is characterized in that: step (1) sealing is placed in shady and cool ventilation place and leaves standstill 4-6 days (preferred, sealing is placed in shady and cool ventilation place and leaves standstill 5 days).
6. the preparation method of thimerosal according to claim 4, is characterized in that: step (1) filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.3-1.8 hour (preferred, filter residue adds water boiled with high heat, changes slow fire and adds thermal distillation 1.5 hours).
7. the preparation method of thimerosal according to claim 4, is characterized in that: step (2) little fire dries 13-18 minute (preferred, little fire dries 15 minutes slowly) slowly.
8. the preparation method of thimerosal according to claim 4, it is characterized in that: honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 33-38 DEG C by step (3), soak 25-35 minute (preferably, honeysuckle, purple perilla, lophatherum gracile and moutan bark are added the warm water of 35 DEG C, soak 30 minutes).
9. the preparation method of thimerosal according to claim 4, is characterized in that: step (3) is heated to boiling, continues to filter after 25-35 minute (preferred, to be heated to boiling, to continue to filter after 30 minutes).
10. the preparation method of thimerosal according to claim 4, it is characterized in that: thick paste is placed in container by step (4) dries 45-55 minute, obtain drying object, it is dry (preferred at temperature is 73-78 DEG C, thick paste is placed in container and dries 50 minutes, obtain drying object, dry at temperature is 75 DEG C).
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105267462A (en) * | 2015-10-20 | 2016-01-27 | 陈会欣 | Sterilization and disinfection traditional Chinese medicine preparation for clinical laboratory staffs and method for preparing sterilization and disinfection traditional Chinese medicine preparation |
| CN105617316A (en) * | 2016-01-02 | 2016-06-01 | 韩凤霞 | Antibacterial disinfectant for clinical laboratory and preparation method |
| CN105746606A (en) * | 2016-02-22 | 2016-07-13 | 李向红 | Clinical laboratory indoor disinfector and preparation method thereof |
| CN106490041A (en) * | 2016-08-31 | 2017-03-15 | 耿会娟 | A kind of clinical laboratory antibacterial thimerosal and preparation method thereof |
| CN111973788A (en) * | 2020-08-27 | 2020-11-24 | 上海中医药大学 | Bacteriostatic formula containing vegetable oil and preparation method and application thereof |
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| CN105267462A (en) * | 2015-10-20 | 2016-01-27 | 陈会欣 | Sterilization and disinfection traditional Chinese medicine preparation for clinical laboratory staffs and method for preparing sterilization and disinfection traditional Chinese medicine preparation |
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| CN111973788A (en) * | 2020-08-27 | 2020-11-24 | 上海中医药大学 | Bacteriostatic formula containing vegetable oil and preparation method and application thereof |
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Application publication date: 20150819 |