CN105746606A - Clinical laboratory indoor disinfector and preparation method thereof - Google Patents
Clinical laboratory indoor disinfector and preparation method thereof Download PDFInfo
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- CN105746606A CN105746606A CN201610095410.8A CN201610095410A CN105746606A CN 105746606 A CN105746606 A CN 105746606A CN 201610095410 A CN201610095410 A CN 201610095410A CN 105746606 A CN105746606 A CN 105746606A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
- A01N65/42—Aloeaceae [Aloe family] or Liliaceae [Lily family], e.g. aloe, veratrum, onion, garlic or chives
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Abstract
The invention relates to a clinical laboratory indoor disinfector and a preparation method thereof and belongs to the field of traditional Chinese medicine. The effective ingredients of the Chinese herba preparation is prepared from the following raw materials: barbados aloe, golden cypress, radix sophorae flavescentis, catalpa leaf, papaya, spinach beet, moutan bark, oriental wormwood, fructus kochiae, jasmine, coptis chinensis, honeysuckle flower, houttuynia cordata, radix bupleuri, creeping oxalis and Cherokee rose leaves. The herbs selected for the Chinese herba preparation are suitable in compatibility, and conform to the traditional Chinese medicine and modern medicine theories; the clinical laboratory indoor disinfector has the characteristics of clearing away heat and toxic materials, diminishing inflammation and resisting bacteria, easily dissolving in water, being high in stability and the like, has no stimulation to the skin of a human body, is high in stability, safe and free from toxic and side effects, can be widely applied to disinfection of a clinical laboratory indoor environment, and can be used for improving the working efficiency of the department of laboratory and ensuring the detection result accuracy, thereby being an ideal anti-resistant disinfectant worthy of popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly to a kind of clinical laboratory's indoor disinfectant and preparation method.
Background technology
Clinical laboratory is the bridge between clinical medicine and preclinical medicine, the subdiscipline such as including clinical chemistry, clinical microbiology, clinical immunology, hematology, osology and transfusion science, undertakes the detection work of various human bodies and the zoological specimens including ward, Emergency call patient, all kinds of health check-up and scientific research every day.
Clinical laboratory is the place that pathogenic microorganism compares concentration, it has concentrated the specimen such as the human body fluid of clinical departments room censorship, blood, respiratory secretions, gastrointestinal tract Excreta, being the key departments of Infection Prevention and control, reviewer is also one of emphasis personnel of monitoring of hospital infection.Therefore, the security protection of clinical laboratory staff is strengthened and the strict sterilization of environment is extremely important.
In prior art, the disinfectant of clinical laboratory's interior space, conventional method has chemical reagent sterilizing, ray sterilizing, dry heat sterilization, warm sterilizing and filtration sterilization and germ killing drugs suffocating sterilization.Although these a few class disinfection way play certain disinfective action, but thorough, pungent of easily sterilizing, the skin of easy damaged reviewer, instability, even can only play the effect purifying air, do not possess the effect to body-care, have a strong impact on the respiratory system of clinical laboratory personnel and the accuracy of sample survey result.
Therefore clinical laboratory indoor disinfectant must safely, effectively, have no side effect, and Chinese materia medica is as the traditional medicine of China, there is the advantages such as effect strong, instant effect, lasting medicine, and there is no dependency, drug resistance and toxic and side effects, soluble in water, stability is high, therefore select a kind of Chinese medicine preparation as clinical laboratory's indoor disinfectant, for checking the environment tool of section office to be of great significance.
Summary of the invention
The invention provides a kind of clinical laboratory's indoor disinfectant and preparation method；Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine is theoretical, there is heat-clearing and toxic substances removing, antiphlogistic antibacterial, soluble in water, stability high, and human body skin is non-stimulated, stability is high, safe without toxic side effect, can be widely applied to the sterilization of clinical laboratory's indoor environment, improve the work efficiency of clinical laboratory personnel, it is ensured that assay
Accuracy rate, is a kind of antibacterial disinfectant solution of the ideal being worthy to be popularized.
For achieving the above object, the enforcement of technical scheme is as follows:
A kind of clinical laboratory indoor disinfectant, raw material composition and the parts by weight of making described disinfectant effective ingredient are:
44～74 portions of Cortex Phellodendris of Aloe, 39～69 parts of Folium catalpae ovatae of 41～71 parts of Radix Sophorae Flavescentiss 37～67 parts
34～64 portions of dishes of Fructus Caricae, 26～56 portions of Herba Artemisiae Scopariaes of 29～59 parts of Cortex Moutans 24～54 parts
22～52 portions of Fructus Gardeniaes of the Fructus Kochiae, 17～47 portions of Flos Loniceraes of 19～49 portions of Rhizoma Coptidis 15～45 parts
14～44 parts of Radix Bupleuri of Herba Houttuyniae, 9～39 parts of Folium Rosae Laevigataes of 10～40 parts of Herba Oxalidis Corniculataes 4～34 parts.
Make described disinfectant effective ingredient raw material composition and parts by weight be:
67 portions of Cortex Phellodendris of Aloe, 62 parts of Folium catalpae ovatae of 64 parts of Radix Sophorae Flavescentiss 60 parts
57 portions of dishes of Fructus Caricae, 50 portions of Herba Artemisiae Scopariaes of 52 parts of Cortex Moutans 48 parts
46 portions of Fructus Gardeniaes of the Fructus Kochiae, 40 portions of Flos Loniceraes of 42 portions of Rhizoma Coptidis 38 parts
37 parts of Radix Bupleuri of Herba Houttuyniae, 32 parts of Folium Rosae Laevigataes of 33 parts of Herba Oxalidis Corniculataes 27 parts.
Make described disinfectant effective ingredient raw material composition and parts by weight be:
60 portions of Cortex Phellodendris of Aloe, 55 parts of Folium catalpae ovatae of 57 parts of Radix Sophorae Flavescentiss 53 parts
50 portions of dishes of Fructus Caricae, 43 portions of Herba Artemisiae Scopariaes of 45 parts of Cortex Moutans 40 parts
39 portions of Fructus Gardeniaes of the Fructus Kochiae, 33 portions of Flos Loniceraes of 35 portions of Rhizoma Coptidis 31 parts
30 parts of Radix Bupleuri of Herba Houttuyniae, 25 parts of Folium Rosae Laevigataes of 26 parts of Herba Oxalidis Corniculataes 20 parts.
Make described disinfectant effective ingredient raw material composition and parts by weight be:
52 portions of Cortex Phellodendris of Aloe, 47 parts of Folium catalpae ovatae of 48 parts of Radix Sophorae Flavescentiss 46 parts
42 portions of dishes of Fructus Caricae, 34 portions of Herba Artemisiae Scopariaes of 37 parts of Cortex Moutans 33 parts
28 portions of Fructus Gardeniaes of the Fructus Kochiae, 26 portions of Flos Loniceraes of 27 portions of Rhizoma Coptidis 23 parts
22 parts of Radix Bupleuri of Herba Houttuyniae, 17 parts of Folium Rosae Laevigataes of 18 parts of Herba Oxalidis Corniculataes 12 parts.
The preparation method of a kind of clinical laboratory indoor disinfectant, comprises the following steps that:
(1) by Aloe, dish, Herba Houttuyniae and Herba Oxalidis Corniculatae decontamination, clean, be placed in container, smash strand juice to pieces, filter, obtain filtrate, standby；
(2) Cortex Phellodendri, Fructus Caricae, Cortex Moutan, Herba Artemisiae Scopariae, the Fructus Kochiae and Fructus Gardeniae decontamination are cleaned, be placed in container, add the distilled water immersion of 8～10 times amount after 4～6 hours, boil 3～4 hours, extract；Again add 5～7 times amount distilled water, boil 2～3 hours, extract；Finally, add 2～4 times amount distilled water, heated and boiled 1～2 hour, extract；Merge three extracting solution, filter, obtain filtrate, standby；
(3) Radix Sophorae Flavescentis, Rhizoma Coptidis and Radix Bupleuri are removed impurity, clean, section, drench into the Sucus Zingberis diluted a little with warm water, mix thoroughly, moistening, put the snail micro-stir-fry of interior slow fire, taking-up cools, and is placed in mortar and grinds into powder, obtains the fine powder of 120 orders, standby；
(4) by Folium catalpae ovatae, Flos Lonicerae and Folium Rosae Laevigatae decontamination, clean, dry, be placed in mortar and grind into powder, obtained the fine powder of 140 orders, standby；
(5) distilled water of 10～12 times amount is added with the fine powder of step (3), step (4) gained after step (1), the filtrate of step (2) gained being mixed, after stirring and dissolving is uniform, heated and boiled 0.5 hour, to less than 60 DEG C, stands 1 hour, filter, filtrate, filtrate fill is sealed up for safekeeping, 121 DEG C of pressure sterilizings 20 minutes, packaging, is described clinical laboratory's indoor disinfectant.
The property of medicine of Chinese medicine used by the present invention is as follows:
Aloe: bitter in the mouth, cold in nature；Return liver, stomach, large intestine channel.Heat clearing away, relieving constipation, parasite killing.For constipation with heat retention, women's amenorrhea, pediatric epilepsy scared, infantile malnutrition with fever malnutrition due to parasitic infestation, tinea skin ulcer hemorrhoid complicated by anal fistula, atrophic rhinitis, scrofula." book on Chinese herbal medicine is new again " carries: " treating the liver fire, town liver-wind, clear away heart-fire heat, and relaxing vexation is slaked thirst and help produce saliva, hearing-improing and eyesight improving, and the tooth that disappears swells, and solves fire-toxin.”
Cortex Phellodendri: bitter in the mouth, cold in nature；Return kidney, bladder warp.Heat clearing and damp drying, pathogenic fire purging is except steaming, detoxification sore treatment.For damp-heat dysentery, jaundice leukorrhagia, pyretic stranguria beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat is passed out semen, sore swollen toxin, eczema pruritus." property of medicine opinion " carries: " main man's impotence.Control the inferior blood such as chicken and duck liver slice；And skin ulcer on man's stem, it is applied in bits end." modern medicine study confirmation, Cortex Phellodendri is contained within berberine, has antibacterial action, and staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium etc. is all effective.
Radix Sophorae Flavescentis: bitter in the mouth, cold in nature；GUIXIN, liver, stomach, large intestine, bladder warp.Heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema eczema, skin pruritus, scabies leprosy." the southern regions of the Yunnan Province book on Chinese herbal medicine " load: " removing heat from blood, relieving heat toxin, mange, impetigo poison.Treat skin pruritus, blood tinea corporis
Skin ulcer, naughty white scales, discharging fresh blood stool, have blood in stool.Pathogenic wind expelling, detumescence poison, expectorant poison.Modern medicine study confirms, tubercule bacillus is had inhibitory action by Radix Sophorae Flavescentis.
Folium catalpae ovatae: bitter in the mouth, cold in nature；GUIXIN, lung meridian.Heat-clearing and toxic substances removing, killing parasites for relieving itching.For fever of children, furuncle scabies.Modern medicine study confirms, staphylococcus aureus, escherichia coli, aerobacteria are had inhibitory action by Folium catalpae ovatae cooling bath, warm macerating liquid.
Fructus Caricae: sweet in the mouth, property is put down.Invigorating the stomach and promoting digestion, nourishes lactogenic, channels sootheing and network vessel quickening.For weakness of the spleen and stomach, inappetence, hypogalactia, Fengshi Guanjie pain, numb limbs and tense tendons, taste-blindness rate pain." south of the Five Ridges gather medicinal herbs record " load: " fruit juice, for anthelmintic and preservative." modern medicine study confirmation, carpaine is to tubercule bacillus slightly inhibitory action, and seed, fruit and root have certain antibacterial action.
Dish: sweet in the mouth, hardship, cold in nature；Return lung, kidney, large intestine channel.Heat-clearing and toxic substances removing, clots absorbing stops blooding.For time row calentura, hemorrhoid, measles without adequate eruption, spit blood, pyretic toxicity dysentery, amenorrhea stranguria with turbid discharge, traumatic injury, snakeworm hinder." occupying diet spectrum with breath " load: " relieving inflammation or internal heat and dispel the wind, parasite killing detoxifies, and washs dirt turbid, and rare variola, leukorrhagia stopping regulating menstruation, treating stranguria dysentery of controlling, children's married woman You Yi eats it.”
Cortex Moutan: bitter in the mouth, pungent, cold nature；GUIXIN, liver, kidney channel.Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, fall and flutter the pain of injury.Staphylococcus albus, bacillus subtilis, escherichia coli, Bacillus typhi etc. are had stronger antibacterial action by Cortex Moutan.
Herba Artemisiae Scopariae: acrid in the mouth, hardship, cold nature；Return spleen, stomach, liver, gallbladder meridian.Clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus, infectious jaundice type hepatitis.
The Fructus Kochiae: acrid in the mouth, hardship, cold in nature；Return kidney, bladder warp.Diuresis, clearing away damp-heat.For dysuria, gonorrhea leukorrhagia, hernia rubella, sore scabies, pudendum pruritus due to damp pathogen." the southern regions of the Yunnan Province book on Chinese herbal medicine " load: " profit bladder urine accumulated heat, washes the wind of skin, treats married woman all through exopathogenic heat, clear profit fetal heat in pregnancy, damp-heat vaginal discharge." modern medicine study confirms, Fructus Kochiae water logging agent is to oidium schoenleinii, and the dermatophytes such as Microsporon audouini has inhibitory action.
Fructus Gardeniae: bitter in the mouth, cold in nature；GUIXIN, lung, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles, bruise pain, infectious hepatitis, traumatic injury, acute toothache." conventional Chinese herbal medicine handbook " load: " heat-clearing and toxic substances removing, removing heat from blood pathogenic fire purging.Controlling icterohepatitis, Semen Viciae fabae is yellow, the high heat of flu, bacillary dysentery, and oedema due to nephritis, epistaxis, dispute is raw
Skin ulcer, mastitis, sore swollen toxin.”
Rhizoma Coptidis: bitter in the mouth, cold in nature；GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomitting acid regurgitation, dysentery jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, and conjunctival congestion is had a toothache, and quenches one's thirst, and carbuncle furuncle, eczema eczema, auditory meatus is suppurated.Modern medicine study confirms, Hemolytic streptococcus, meningococcus, Diplococcus pneumoniae, vibrio cholera, anthrax bacillus and staphylococcus aureus are all had stronger bacteriostasis by Rhizoma Coptidis, dysentery bacterium, diphtheria corynebacterium, bacillus subtilis, viridans streptococci all there are is inhibitory action, pneumobacillus, bordetella pertussis, bacillus pestis, Brucella, clostridium tetani, bacillus perfringens, tubercule bacillus etc. is also effective.
Flos Lonicerae: sweet in the mouth, cold in nature；Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat." conventional Chinese herbal medicine handbook " load: " heat-clearing and toxic substances removing.Control fever caused by exogenous pathogens cough, enteritis, bacillary dysentery, measles, parotitis, septicemia, furuncle toxic swelling, appendicitis, trauma infection contamination, children's's hidradenitis suppurativa.Make herbal tea, heatstroke, flu and infectious intestinal disease can be prevented." modern medicine study confirmation; various bacteria (Bacillus typhi, Salmonella paratyphi, escherichia coli, Bacillus proteus, bacillus pyocyaneus, bordetella pertussis, vibrio cholera and staphylococcus, streptococcus, Diplococcus pneumoniae, meningococcus etc.) is all had inhibitory action by Flos Lonicerae.
Herba Houttuyniae: acrid in the mouth, cold nature；Return lung meridian.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea pyretic stranguria, carbuncle sore tumefacting virus.Modern medicine study confirms, the effective ingredient houttuynine sodium bisulfite micrococcus catarrhalis of Herba Houttuyniae, hemophilus influenza, streptococcus pneumoniae, staphylococcus aureus have obvious inhibiting effect.
Radix Bupleuri: bitter in the mouth, cold nature.Reconciling superficies and interior, soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official prolapses, proctoptosis." medicine origin " carries: " except asthenia dysphoria with smothery sensation, dismisses flesh heat, removes hectic fever in morning.”
Herba Oxalidis Corniculatae: sour in the mouth, cold in nature.Clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis, subduing swelling and detoxicating.For dysentery, jaundice gonorrhea, leucorrhea with red and white discharge, measles is spitted blood, laryngopharynx swelling and pain, furuncle carbuncle, scabies haemorrhoids, proctoptosis, traumatic injury, burn.Tang Materia Medica carry: " the lame fistula of main malignant boil smash deposited it, kill all small worms." " food antipyretic yearningly." modern medicine study confirmation, staphylococcus aureus is had antibacterial action by Herba Oxalidis Corniculatae.
Folium Rosae Laevigatae: bitter in the mouth, property is put down；Return lung, heart channel.Heat-clearing and toxic substances removing, promoting blood circulation and hemostasis, leukorrhagia stopping.For carbuncle
Furuncle, scalds dysentery, amenorrhea metrorrhagia, leukorrhagia, wound hemorrhage." the SHENGCAO property of medicine standby will " load: " sterilization of reducing phlegm and internal heat.Wash chancre.”
The present invention compared with prior art, has the advantages that
Selected by Chinese medicine preparation of the present invention, medical material compatibility is suitable, meet Chinese medicine and modern medicine is theoretical, there is heat-clearing and toxic substances removing, antiphlogistic antibacterial, soluble in water, stability high, and human body skin is non-stimulated, stability is high, safe without toxic side effect, can be widely applied to the sterilization of clinical laboratory's indoor environment, improves the work efficiency of clinical laboratory personnel, ensure that the accuracy rate of assay, be a kind of antibacterial disinfectant solution of the ideal being worthy to be popularized.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Aloe 73g Cortex Phellodendri 70g Radix Sophorae Flavescentis 68g Folium catalpae ovatae 66g
Fructus Caricae 63g dish 58g Cortex Moutan 55g Herba Artemisiae Scopariae 53g
Fructus Kochiae 51g Fructus Gardeniae 48g Rhizoma Coptidis 46g Flos Lonicerae 44g
Herba Houttuyniae 43g Radix Bupleuri 39g Herba Oxalidis Corniculatae 38g Folium Rosae Laevigatae 33g.
The preparation method of Chinese medicine preparation of the present invention, comprises the following steps that:
(1) by Aloe, dish, Herba Houttuyniae and Herba Oxalidis Corniculatae decontamination, clean, be placed in container, smash strand juice to pieces, filter, obtain filtrate, standby；
(2) Cortex Phellodendri, Fructus Caricae, Cortex Moutan, Herba Artemisiae Scopariae, the Fructus Kochiae and Fructus Gardeniae decontamination are cleaned, be placed in container, add the distilled water immersion of 8～10 times amount after 4～6 hours, boil 3～4 hours, extract；Again add 5～7 times amount distilled water, boil 2～3 hours, extract；Finally, add 2～4 times amount distilled water, heated and boiled 1～2 hour, extract；Merge three extracting solution, filter, obtain filtrate, standby；
(3) Radix Sophorae Flavescentis, Rhizoma Coptidis and Radix Bupleuri are removed impurity, clean, section, drench into the Sucus Zingberis diluted a little with warm water, mix thoroughly, moistening, put the snail micro-stir-fry of interior slow fire, taking-up cools, and is placed in mortar and grinds into powder, obtains the fine powder of 120 orders, standby；
(4) by Folium catalpae ovatae, Flos Lonicerae and Folium Rosae Laevigatae decontamination, clean, dry, be placed in mortar and grind into powder, obtained the fine powder of 140 orders, standby；
(5) distilled water of 10～12 times amount is added with the fine powder of step (3), step (4) gained after step (1), the filtrate of step (2) gained being mixed, after stirring and dissolving is uniform, heated and boiled 0.5 hour, to less than 60 DEG C, stands 1 hour, filter, filtrate, filtrate fill is sealed up for safekeeping, 121 DEG C of pressure sterilizings 20 minutes, packaging, is described clinical laboratory's indoor disinfectant.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Aloe 67g Cortex Phellodendri 64g Radix Sophorae Flavescentis 62g Folium catalpae ovatae 60g
Fructus Caricae 57g dish 52g Cortex Moutan 50g Herba Artemisiae Scopariae 48g
Fructus Kochiae 46g Fructus Gardeniae 42g Rhizoma Coptidis 40g Flos Lonicerae 38g
Herba Houttuyniae 37g Radix Bupleuri 33g Herba Oxalidis Corniculatae 32g Folium Rosae Laevigatae 27g.
The Chinese medicine preparation preparation method processing step of the present embodiment is identical with embodiment 1.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Aloe 60g Cortex Phellodendri 57g Radix Sophorae Flavescentis 55g Folium catalpae ovatae 53g
Fructus Caricae 50g dish 45g Cortex Moutan 43g Herba Artemisiae Scopariae 40g
Fructus Kochiae 39g Fructus Gardeniae 35g Rhizoma Coptidis 33g Flos Lonicerae 31g
Herba Houttuyniae 30g Radix Bupleuri 26g Herba Oxalidis Corniculatae 25g Folium Rosae Laevigatae 20g.
The Chinese medicine preparation preparation method processing step of the present embodiment is identical with embodiment 1.
Embodiment 4
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and weight is:
Aloe 52g Cortex Phellodendri 48g Radix Sophorae Flavescentis 47g Folium catalpae ovatae 46g
Fructus Caricae 42g dish 37g Cortex Moutan 34g Herba Artemisiae Scopariae 33g
Fructus Kochiae 28g Fructus Gardeniae 27g Rhizoma Coptidis 26g Flos Lonicerae 23g
Herba Houttuyniae 22g Radix Bupleuri 18g Herba Oxalidis Corniculatae 17g Folium Rosae Laevigatae 12g.
The Chinese medicine preparation preparation method processing step of the present embodiment is identical with embodiment 1.
Experimental section
Below the selection present invention is tested accordingly, prove effect of the present invention further.
One, soluble test
1, take clinical laboratory of the present invention indoor disinfectant 10ml and put in container, be subsequently adding distilled water, after stirring, filter.
2, after having filtered, filter paper is observed, without obvious residue on filter paper.
3, conclusion: clinical laboratory of the present invention indoor disinfectant is highly soluble in water, uses rear noresidue impurity to occur.
Two, toxicity test
1, acute oral test: choosing the healthy Kunming kind one-level mice 26 of quality 20～22g, male and female half and half, by clinical laboratory of the present invention indoor disinfectant per os gastric infusion, administration is observed 15 days, records the various performance of mice and death condition every day, calculates LD. value.
2, cumulative toxicity test: choose the healthy Kunming kind one-level rat 26 of quality 180～200g, male and female half and half, by clinical laboratory of the present invention indoor disinfectant per os gastric infusion, dosage tests the DL. value drawn according to acute oral, the 1st～6 day, is administered 0.1LD. every time, within every four hours later, it is incremented by 1.5 multiple doses, it is administered 30 days, and every four hours weigh once, calculate cumulative coefficient.
3, there is not death in result: no abnormality seen reaction after acute oral test mice perfusion, and after it is carried out dissection accordingly, tissue or internal organs have no and substantially have obvious abnormal change.
After cumulative toxicity test is administered 30 days, male and female mice all occurs without death condition, mice cumulative coefficient 5, the weak cumulative toxicity in position.
Three, Ocular irritation test
1, healthy white rabbit 6 is selected, weight 3～3.5kg, clinical laboratory of the present invention indoor disinfectant stock solution 0.1ml is instilled in rabbit conjunctiva of left eye capsule, with normal saline flushing after passive Guan Bi 4s, right eye instills normal saline as comparison.
2, rabbit 12 hours, 24 hours, 36 hours and 48 hours interior eyes localized variation are observed.
3, result: rabbit contamination group cornea and iris are normal, and conjunctiva has no edema, and having slight hyperemia, conjunctiva stimulation index is 1, by acute ocular stimulus intensity analytic intensity grade scale, belongs to nonirritant.
Four, irritation test
1, selecting healthy white rabbit 6, weight 3-3.5kg, by the depilation point of family's rabbit back spinal column both sides
Not Wei 3.0cm × 3.0cm, do not damage epidermis, after 24 hours, by clinical laboratory of the present invention for 0.2ml indoor disinfectant uniform application in the left side of baring skin, right side is not smeared as comparison, after 6 hours, by clean for skin wiping, observes dermoreaction, carries out stimulating scoring.
2, result: rabbit baring skin reacts there are no erythema and edema, and skin wound repair integrated value is 0, control sides skin no abnormality seen, by skin wound repair standards of grading, reaction integral mean value is 0, and disinfectant solution of the present invention is to no skin irritation.
Five, stability test
Take clinical laboratory of the present invention indoor disinfectant 50ml, after placing 90 days under 37 DEG C of conditions, for staphylococcus aureus is sterilized, before its killing effect and storage, compare no significant difference.
Six, bacteriostatic test
Below clinical laboratory of the present invention indoor disinfectant is carried out bacteriostatic experiment:
1, experimental strain:
Select the strain that laboratory is representative, staphylococcus aureus and bacillus pyocyaneus.
2, bacterium culture medium:
Nutrient agar and nutrient broth medium.
3, experiment classification:
Bacteriostatic experiment divides experimental group and matched group, and experimental group selects clinical laboratory of the present invention indoor disinfectant, and matched group selects lysol.
4, specific experiment step:
(1) preparation of bacterium solution: above two strain is inoculated in respectively on two agar culture mediums, cultivating 24 hours at 37 DEG C, from above-mentioned agar culture medium, picking colonies typical is inoculated in two fresh nutrient broth mediums respectively respectively, under synthermal, cultivate 24 hours, standby；
(2) take clinical laboratory of the present invention indoor disinfectant and each 30ml of lysol, be respectively placed in cut-back tank, it is diluted respectively 25 times, above two diluent solution is split in two containers respectively, is placed under aseptic condition, standby；
(3) above-mentioned steps (1) is supported through nutrition broth cultivation the aseptic nutrient meat of experimental strain of 24 hours
Soup dilutes 50 times respectively, and every kind of strain is sub-packed in two culture dishs, respectively labelling matched group and experimental group；
(4) dilute solution of the Liang Fen clinical laboratory of the present invention indoor disinfectant of above-mentioned steps (2) gained being respectively dropped into experimental group culture dish, two parts of lysol dilute solutions are respectively dropped into matched group culture dish.
5, experimental observation is measured:
Above-mentioned experiment is observed, observes two groups of strains and measure strain revolution mark concrete outcome.
6, after observation is measured, above-mentioned culture dish is placed under aseptic condition and stands two days, after liquid volatilizees completely, follow the tracks of it has been observed that matched group bacterium colony continues breeding, and experimental group bacterium colony is unchanged.
7, experimental result:
The sterilizing ability of experimental group clinical laboratory of the present invention indoor disinfectant is much larger than the sterilizing ability of matched group disinfectant solution, and all kinds of strain can be suppressed to continue breeding.
Claims (5)
1. clinical laboratory's indoor disinfectant, it is characterised in that: make described disinfectant effective ingredient raw material composition and parts by weight be:
44～74 portions of Cortex Phellodendris of Aloe, 39～69 parts of Folium catalpae ovatae of 41～71 parts of Radix Sophorae Flavescentiss 37～67 parts
34～64 portions of dishes of Fructus Caricae, 26～56 portions of Herba Artemisiae Scopariaes of 29～59 parts of Cortex Moutans 24～54 parts
22～52 portions of Fructus Gardeniaes of the Fructus Kochiae, 17～47 portions of Flos Loniceraes of 19～49 portions of Rhizoma Coptidis 15～45 parts
14～44 parts of Radix Bupleuri of Herba Houttuyniae, 9～39 parts of Folium Rosae Laevigataes of 10～40 parts of Herba Oxalidis Corniculataes 4～34 parts.
2. a kind of clinical laboratory according to claim 1 indoor disinfectant, it is characterised in that: raw material composition and the parts by weight of making described disinfectant effective ingredient are:
67 portions of Cortex Phellodendris of Aloe, 62 parts of Folium catalpae ovatae of 64 parts of Radix Sophorae Flavescentiss 60 parts
57 portions of dishes of Fructus Caricae, 50 portions of Herba Artemisiae Scopariaes of 52 parts of Cortex Moutans 48 parts
46 portions of Fructus Gardeniaes of the Fructus Kochiae, 40 portions of Flos Loniceraes of 42 portions of Rhizoma Coptidis 38 parts
37 parts of Radix Bupleuri of Herba Houttuyniae, 32 parts of Folium Rosae Laevigataes of 33 parts of Herba Oxalidis Corniculataes 27 parts.
3. a kind of clinical laboratory according to claim 1 indoor disinfectant, it is characterised in that: raw material composition and the parts by weight of making described disinfectant effective ingredient are:
60 portions of Cortex Phellodendris of Aloe, 55 parts of Folium catalpae ovatae of 57 parts of Radix Sophorae Flavescentiss 53 parts
50 portions of dishes of Fructus Caricae, 43 portions of Herba Artemisiae Scopariaes of 45 parts of Cortex Moutans 40 parts
39 portions of Fructus Gardeniaes of the Fructus Kochiae, 33 portions of Flos Loniceraes of 35 portions of Rhizoma Coptidis 31 parts
30 parts of Radix Bupleuri of Herba Houttuyniae, 25 parts of Folium Rosae Laevigataes of 26 parts of Herba Oxalidis Corniculataes 20 parts.
4. a kind of clinical laboratory according to claim 1 indoor disinfectant, it is characterised in that: raw material composition and the parts by weight of making described disinfectant effective ingredient are:
52 portions of Cortex Phellodendris of Aloe, 47 parts of Folium catalpae ovatae of 48 parts of Radix Sophorae Flavescentiss 46 parts
42 portions of dishes of Fructus Caricae, 34 portions of Herba Artemisiae Scopariaes of 37 parts of Cortex Moutans 33 parts
28 portions of Fructus Gardeniaes of the Fructus Kochiae, 26 portions of Flos Loniceraes of 27 portions of Rhizoma Coptidis 23 parts
22 parts of Radix Bupleuri of Herba Houttuyniae, 17 parts of Folium Rosae Laevigataes of 18 parts of Herba Oxalidis Corniculataes 12 parts.
5. the preparation method of the clinical laboratory's indoor disinfectant as described in any one of claim 1-4, it is characterised in that: comprise the following steps that:
(1) by Aloe, dish, Herba Houttuyniae and Herba Oxalidis Corniculatae decontamination, clean, be placed in container, smash strand juice to pieces, filter, obtain filtrate, standby；
(2) Cortex Phellodendri, Fructus Caricae, Cortex Moutan, Herba Artemisiae Scopariae, the Fructus Kochiae and Fructus Gardeniae decontamination are cleaned, be placed in container, add the distilled water immersion of 8～10 times amount after 4～6 hours, boil 3～4 hours, extract；Again add 5～7 times amount distilled water, boil 2～3 hours, extract；Finally, add 2～4 times amount distilled water, heated and boiled 1～2 hour, extract；Merge three extracting solution, filter, obtain filtrate, standby；
(3) Radix Sophorae Flavescentis, Rhizoma Coptidis and Radix Bupleuri are removed impurity, clean, section, drench into the Sucus Zingberis diluted a little with warm water, mix thoroughly, moistening, put the snail micro-stir-fry of interior slow fire, taking-up cools, and is placed in mortar and grinds into powder, obtains the fine powder of 120 orders, standby；
(4) by Folium catalpae ovatae, Flos Lonicerae and Folium Rosae Laevigatae decontamination, clean, dry, be placed in mortar and grind into powder, obtained the fine powder of 140 orders, standby；
(5) distilled water of 10～12 times amount is added with the fine powder of step (3), step (4) gained after step (1), the filtrate of step (2) gained being mixed, after stirring and dissolving is uniform, heated and boiled 0.5 hour, to less than 60 DEG C, stands 1 hour, filter, filtrate, filtrate fill is sealed up for safekeeping, 121 DEG C of pressure sterilizings 20 minutes, packaging, is described clinical laboratory's indoor disinfectant.
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| CN107279199A (en) * | 2017-06-21 | 2017-10-24 | 合肥华盖生物科技有限公司 | A kind of indoor disinfectant and preparation method thereof |
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| CN110025691A (en) * | 2019-04-30 | 2019-07-19 | 龙岩学院 | A kind of compound houttuynia cordata preparation and preparation method and application |
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Application publication date: 20160713 |