CN106259501A - A kind of operating room special sterilizing disinfectant solution and preparation method - Google Patents

A kind of operating room special sterilizing disinfectant solution and preparation method Download PDF

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CN106259501A
CN106259501A CN201610495777.9A CN201610495777A CN106259501A CN 106259501 A CN106259501 A CN 106259501A CN 201610495777 A CN201610495777 A CN 201610495777A CN 106259501 A CN106259501 A CN 106259501A
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herba
operating room
standby
disinfectant solution
solution
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孙奉生
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/34—Rosaceae [Rose family], e.g. strawberry, hawthorn, plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/86—Violaceae (Violet family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Abstract

The invention discloses a kind of operating room special sterilizing disinfectant solution and preparation method, belong to the field of Chinese medicines；The raw material of disinfection solution effective ingredient of the present invention consists of: Caulis te Folium Callicarpae Longissimae, Resina garciniae, poinsettia, Herba Centellae, Viola grypoceras A. Gray, Herba Houttuyniae, Cortex Magnoliae Officinalis, Herba Beronicastri brunoniani, Folium Pruni pseudocerasi, Flos Lonicerae, the Radix Aucklandiae, Cortex seu flos hibisci tiliacei, Herba Rostellulariae, Herba Euphorbiae Helioscopiae, Radix Achyranthis and Amaranthus mangostanus L.；Selected by disinfection solution of the present invention, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, to human body skin nonirritant, skin can be made to feel nice and cool smooth, can be widely applied to the sterilizing of operating room personnel's skin and medical space, and it is strong to have sterilizing power, effect is rapidly, good stability, has no side effect, non-corrosiveness, soluble in water, advantage with low cost, is a kind of preferably disinfection solution, and should be widely promoted application.

Description

A kind of operating room special sterilizing disinfectant solution and preparation method
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of operating room special sterilizing disinfectant solution and preparation method.
Background technology
Disinfectant solution in the market is varied, but great majority are both for human body antibacterial aspect and configure, it is impossible to Medical personnel itself and operating room are carried out omnibearing thorough disinfection, mainly eliminates a series of antibacterial and pathogen Such as staphylococcus aureus, escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, proteus vulgaris etc., carry for operating room For good environment.The sterilizing medicine that operating room uses is made up of chemicals mostly, and the chemicals of this kind is to people Body skin has serious zest, is unfavorable for the carrying out of operation, and have even can cause serious anaphylaxis, if sterilizing The most thorough, it is easy to make patient wound suppurate, the state of an illness of patient can be had a strong impact on.Therefore, a kind of disinfection solution opponent is found Art room staff and patient are very important.
Summary of the invention
The invention provides a kind of operating room special sterilizing disinfectant solution and preparation method；Medicine selected by disinfection solution of the present invention Material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, to human body skin nonirritant, skin can be made to feel nice and cool smooth, Can be widely applied to the sterilizing of operating room personnel's skin and medical space, and it is strong to have sterilizing power, effect is rapidly, stable Property good, have no side effect, non-corrosiveness, advantage soluble in water, with low cost, is a kind of preferably disinfection solution, is worth Wide popularization and application.
For achieving the above object, technical scheme is implemented as follows:
A kind of operating room special sterilizing disinfectant solution, makes raw material composition and the weight portion of described disinfection solution effective ingredient Number is:
Make described disinfection solution effective ingredient raw material composition and parts by weight be:
Make described disinfection solution effective ingredient raw material composition and parts by weight be:
Make described disinfection solution effective ingredient raw material composition and parts by weight be:
The preparation method of a kind of operating room special sterilizing disinfectant solution, comprises the following steps that:
(1) Caulis te Folium Callicarpae Longissimae, Folium Pruni pseudocerasi, Cortex seu flos hibisci tiliacei and Amaranthus mangostanus L. are cleaned, chopping, put into container, twist juice, filter impurity, stay juice Standby；
(2) Resina garciniae and Herba Houttuyniae are put into container, carry out pulverization process, grind into powder, obtain the fine powder of 180 mesh, standby；
(3) poinsettia is dried in the sun, put into slow fire parch in pot, dry in the air cool, carry out pulverization process, grind into powder, obtain Cross the fine powder of 200 mesh, standby；
(4) Herba Centellae, Cortex Magnoliae Officinalis, Herba Beronicastri brunoniani, Herba Rostellulariae and Herba Euphorbiae Helioscopiae are cleaned, put into container, add the distillation of 8～10 times amount Water, after soaking 5～6 hours, boils 3～4 hours, extracts；Again add 6～8 times amount distilled water, boil 2～3 hours, extract； Finally, add 4～6 times amount distilled water, heated and boiled 1～2 hours, extract；Merge three extracting solution, filter, obtain filtrate, standby With；
(5) Viola grypoceras A. Gray is cleaned, chopping, put into container, add Mel and stir, stand half an hour, be subsequently adding 3 The distilled water of times amount, stirs, and filters impurity, stays juice standby；
(6) Flos Lonicerae and Radix Achyranthis are cleaned, immerse 3 times amount 60% alcohol solution dipping 1～2 hours, heating carries Take 3 hours, reclaim ethanol, filter, obtain filtrate, standby；
(7) by Radix Aucklandiae cleaning, drying, mill with stone grinder, mill and add a small amount of water simultaneously, obtain extract, standby；
(8), after the juice obtained by above-mentioned steps (1)～(7), fine powder, filtrate and extract being mixed, 10-12 times is added The distilled water of amount, after stirring and dissolving is uniform, heated and boiled 0.5 hour, to less than 60 DEG C, stand 1 hour, filter, obtain filtrate, will Filtrate fill is sealed up for safekeeping, is described operating room special sterilizing disinfectant solution.
The property of medicine of Chinese medicine used by the present invention is as follows:
Caulis te Folium Callicarpae Longissimae: acrid in the mouth, micro-hardship, warm in nature.Expelling wind and cold, dissipating blood stasis stops blooding, removing toxic substances and promoting subsidence of swelling.Main cough due to wind and cold, abdominal pain due to accumulation of cold, Rheumatic arthralgia, traumatic injury, interior traumatic hemorrhage, innominate toxic swelling.
Resina garciniae: sour in the mouth, puckery, cool in nature.Detumescence, removing toxic substances, hemostasis, parasite killing.Control swollen ulcer drug, stubborn dermatitis malignant boil, bleeding due to trauma, tooth Infantile malnutrition decayed tooth, burn.Modern medicine study confirms, the morellin that Resina garciniae is contained within has inhibitory action to staphylococcus aureus.
Poinsettia: bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Cure mainly upper respiratory tract infection, oral ulcer, pneumonia, breast Adenitis, enteritis, bacillary dysentery, urinary tract infection, furuncle carbuncle, eczema, traumatic injury, heat clearing away." Guangxi practicality Chinese herbal medicine newly selects " carries: " anti-inflammation.Control acute upper respiratory tract scorching, pneumonia, tonsillitis, oral ulcer, mastitis, chronic pelvic inflammatory disease, dysentery, abdomen Rush down, venom.”
Herba Centellae: bitter in the mouth, pungent, cold in nature；Return liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Cure mainly conjunctival congestion and swelling pain, damp and hot Jaundice, heatstroke diarrhoea, stranguria caused by urinary stone stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.Modern medicine study confirms, Herba Centellae water extract has The effect of anti-inflammation.
Viola grypoceras A. Gray: mildly bitter flavor, cool in nature.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, cooling blood for hemostasis.Cure mainly carbuncle sore, pharyngitis, acute mastitis, Acute conjunctivitis, knife injury is hemorrhage, and traumatic injury is had blood in stool, venom.
Herba Houttuyniae: acrid in the mouth, cold nature；Enter lung meridian.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome, be usually used in treat lung abscess, The disease such as cough due to lung-heat, sore swollen toxin.Modern pharmacological research shows, the multiple one-tenth such as the volatile oil that contains in Herba Houttuyniae, houttuynine sodium bisulfite Point, the various pathogens such as staphylococcus aureus, Diplococcus pneumoniae and influenza virus, leptospira etc. there are is stronger pressing down Make use, the phagocytic activity of leukocyte and macrophage can be strengthened, improve body immunity.Additionally, also radiation resistance and The effect of enhancing human body immunity function, and without any side effects.
Cortex Magnoliae Officinalis: bitter in the mouth, pungent, warm in nature；Enter spleen, stomach, lung, large intestine channel.Circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma.Cure mainly food Pneumatosis is stagnant, abdominal distention constipation, retention of dampness in middle-JIAO, and gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant stops up QI rising in reverse order, and fullness in the chest is breathed with cough.Modern medicine study confirms, Cortex Magnoliae Officinalis is to dysentery Shigella, escherichia coli, Bacillus typhi have stronger antibacterial action, to the antibacterial action of staphylococcus aureus than Rhizoma Coptidis, Huang A kind of reed mentioned in ancient books is higher.
Herba Beronicastri brunoniani: bitter in the mouth, cold in nature.Eliminating inflammation and expelling toxin, relieving cough and resolving phlegm, lowering the adverse-rising QI to subdue asthma, reducing swelling and alleviating pain.Cure mainly tonsillitis, stomach Burning pain, cystitis, mastitis, carbuncle sore tumefacting virus, dysentery, chronic tracheitis etc.." Xinhua's book on Chinese herbal medicine outline " carries: " bitter in the mouth, property Cold.There is anti-inflammation and sterilization, detoxify, dissipate swollen function.For tonsillitis, gastric heat pain, cystitis, mastitis, carbuncle sore tumefacting virus, red in vain Dysentery.”
Folium Pruni pseudocerasi: sweet-bitter flavor, warm in nature, nontoxic；Return liver, spleen, lung meridian.Warming middle-JIAO and strengthening the spleen, cough-relieving hemostasis, detoxify parasite killing.Main stomach Cold food amasss, diarrhoea, and cough is spitted blood, and skin infection swells carbuncle, snake bite and insect sting, trichomonas vaginitis." book on Chinese herbal medicine is the newest " carries: " nourishing the liver helps fire, spleen invigorating Appetizing, long-pending except gastral cavilty trembles with fear, and helps digestion brokenly stagnant.”
Flos Lonicerae: sweet in the mouth, micro-hardship, cold in nature；Return lung, stomach, the heart, large intestine channel.Heat clearing away is eliminating evil, dispelling wind-heat, removing summer-heat blood poison.Existing Showing for pharmacological research, the effective ingredient in Flos Lonicerae has antibacterial and antivirus action, to staphylococcus aureus, hemolytic Streptococcus, dysentery bacterium, Bacillus typhi, meningococcus, Diplococcus pneumoniae, bacillus pyocyaneus and influenza virus etc. have bright Aobvious inhibitory action, and immunologic function can be strengthened, antiinflammatory, antipyretic, inflammation there is is obvious inhibiting effect.
The Radix Aucklandiae: acrid in the mouth, hardship, warm in nature；Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Swollen for breast gastral cavity Bitterly, weight after dysentery, food stagnation does not disappears, anorexia.Modern medicine study confirms, volatile oil of Radix Aucklandiae 1: 3000 concentration can suppress hammer Bacterium, the golden yellow growth with Staphylococcus albus, faint with diphtheria corynebacterium effect to escherichia coli, this product decoct is except to paratyphoid fever 10 kinds of funguses such as first bacillus, oidium schoenleinii and Mongolia's mutation thereof are the most inhibited.
Cortex seu flos hibisci tiliacei: sweet in the mouth, light, cold nature；Return lung meridian.Clearing away lung-heat to relieve cough, removing toxic substances and promoting subsidence of swelling.Main cough due to lung-heat, furuncle swells and ache, Maninot esculenta crantz. Poisoning." Xinhua's book on Chinese herbal medicine outline " carry: " effect have bring down a fever, emesis, cough-relieving function, be used for cough bronchitis of having a fever；The outer edema of the dorsum of the foot Poison.”
Herba Rostellulariae: mildly bitter flavor, cold in nature.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, preventing the attack (or recurrence) of malaria.For cold, fever, malaria, laryngopharynx swelling and pain is little Youngster's infantile malnutrition, dysentery, enteritis, oedema due to nephritis, urinary system infection, chyluria；Ulcerative carbuncle furuncle and phyma, traumatic injury are controlled in external.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing, disappear stagnant dissipating blood stasis.Cure cold fever, laryngopharynx swelling and pain, infantile malnutrition, acute mastitis, hepatitis, Traumatic injury.”
Herba Euphorbiae Helioscopiae: acrid in the mouth, hardship, cool in nature；Return large and small intestinal, spleen channel.Row water expectorant, parasite killing detoxifies.Cure mainly edematous asthma, phlegm retention Breath with cough, malaria, bacillary dysentery, scrofula, tinea skin ulcer, Tuberculous flaccidity pipe, osteomyelitis.Essentials of Matea Medica carries: " cough-relieving, parasite killing." modern medicine Research confirms, during Herba Euphorbiae Helioscopiae high concentration decoct, can suppress the growth of tubercule bacillus.
Radix Achyranthis: become silted up resistance arthralgia pain, antiinflammatory diuresis.Control gonorrhea, hematuria, women's amenorrhea, lump in the abdomen, rheumatic arthritis, tinea pedis, dysentery Disease, malaria, diphtheria, carbuncle, traumatic injury." Chinese herbal medicine handbook is commonly used in Shanghai " carries: " diuresis of stimulating the menstrual flow, heat-clearing and toxic substances removing, only invigorate blood circulation Bitterly.Control tinea pedis swelling, arthritis, rheumatalgia, diphtheria, acute/chronic pharyngitis.”
Amaranthus mangostanus L.: sweet in the mouth, cold nature；Return large intestine, small intestine meridian.Heat-clearing and toxic substances removing, smoothening secretion.Cure mainly dysentery, constipation and anuresis, Serpentis Insect sting, sore." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " controls sphincter disturbance, changes worm and remove cold and heat, energy promoting blood circulation, removing blood stasis blood." modern medicine grinds Studying carefully confirmation, nalka hydro carbons in Amaranthus mangostanus L. extract, nalka alcohols, sterols are to staphylococcus aureus, Staphylococcus albus, grass Viridans streptococci, colibacillus, Pseudomonas aeruginosa and klebsiella bacillus have stronger antibacterial action.
The present invention compared with prior art, has the advantages that
Selected by disinfection solution of the present invention, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, to human body No skin irritation, can make skin feel nice and cool smooth, and the sterilization that can be widely applied to operating room personnel's skin and medical space disappears Poison, and it is strong to have sterilizing power, effect is rapid, and good stability has no side effect, and non-corrosiveness, soluble in water, with low cost is excellent Point, is a kind of preferably disinfection solution, and should be widely promoted application.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of disinfection solution effective ingredient of the present invention forms and weight is:
The preparation method of a kind of operating room special sterilizing disinfectant solution, comprises the following steps that:
(1) Caulis te Folium Callicarpae Longissimae, Folium Pruni pseudocerasi, Cortex seu flos hibisci tiliacei and Amaranthus mangostanus L. are cleaned, chopping, put into container, twist juice, filter impurity, stay juice Standby；
(2) Resina garciniae and Herba Houttuyniae are put into container, carry out pulverization process, grind into powder, obtain the fine powder of 180 mesh, standby；
(3) poinsettia is dried in the sun, put into slow fire parch in pot, dry in the air cool, carry out pulverization process, grind into powder, obtain Cross the fine powder of 200 mesh, standby；
(4) Herba Centellae, Cortex Magnoliae Officinalis, Herba Beronicastri brunoniani, Herba Rostellulariae and Herba Euphorbiae Helioscopiae are cleaned, put into container, add the distillation of 8～10 times amount Water, after soaking 5～6 hours, boils 3～4 hours, extracts；Again add 6～8 times amount distilled water, boil 2～3 hours, extract； Finally, add 4～6 times amount distilled water, heated and boiled 1～2 hours, extract；Merge three extracting solution, filter, obtain filtrate, standby With；
(5) Viola grypoceras A. Gray is cleaned, chopping, put into container, add Mel and stir, stand half an hour, be subsequently adding 3 The distilled water of times amount, stirs, and filters impurity, stays juice standby；
(6) Flos Lonicerae and Radix Achyranthis are cleaned, immerse 3 times amount 60% alcohol solution dipping 1～2 hours, heating carries Take 3 hours, reclaim ethanol, filter, obtain filtrate, standby；
(7) by Radix Aucklandiae cleaning, drying, mill with stone grinder, mill and add a small amount of water simultaneously, obtain extract, standby；
(8), after the juice obtained by above-mentioned steps (1)～(7), fine powder, filtrate and extract being mixed, 10-12 times is added The distilled water of amount, after stirring and dissolving is uniform, heated and boiled 0.5 hour, to less than 60 DEG C, stand 1 hour, filter, obtain filtrate, will Filtrate fill is sealed up for safekeeping, is described operating room special sterilizing disinfectant solution.Usage and dosage: behind Sterile surgery room, takes the present invention and kills Bacterium disinfectant solution 10～20ml, is placed in disinfecting container, adds the water of 3～5 times, is uniformly sprayed in operating room, opponent after stirring Art room carries out sterilizing.
Embodiment 2
The raw material of disinfection solution effective ingredient of the present invention forms and weight is:
The sterilizing liquid and preparation method thereof processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of disinfection solution effective ingredient of the present invention forms and weight is:
The sterilizing liquid and preparation method thereof processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of disinfection solution effective ingredient of the present invention forms and weight is:
The sterilizing liquid and preparation method thereof processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 5
The raw material of disinfection solution effective ingredient of the present invention forms and weight is:
The sterilizing liquid and preparation method thereof processing step of the present embodiment and usage and dosage are same as in Example 1.
Experimental section
Below disinfection solution of the present invention for selection is tested accordingly, prove disinfection solution of the present invention further Effect.
One, soluble test
1, take disinfection solution 10ml of the present invention and put in container, be subsequently adding distilled water, after stirring, filter.
2, after having filtered, filter paper is observed, without obvious residue on filter paper.
3, conclusion: disinfection solution of the present invention is highly soluble in water, uses rear noresidue impurity to occur.
Two, toxicity test
1, acute oral test: choose the healthy Kunming kind one-level mice 20 of quality 18-20g, male and female half and half, incite somebody to action this Invention disinfection solution per os gastric infusion, is administered and observes 10 days, record the various performance of mice and death condition every day, calculates LD. it is worth.
2, cumulative toxicity test: choose the healthy Kunming kind one-level rat 20 of body weight 160-180g, male and female half and half, incite somebody to action this Invention disinfection solution per os gastric infusion, dosage is tested the DL. value drawn, the 1-4 days, is given every time according to acute oral Medicine 0.1LD., is incremented by 1.5 multiple doses, is administered 20 days, and every four hours weigh once, calculate cumulative coefficient for later every four hours.
3, there is not death, solves it accordingly in result: no abnormality seen reaction after acute oral test mice perfusion After cuing open, tissue or internal organs show no obvious abnormalities change；After cumulative toxicity test is administered 15 days, mice all sends out male and female without death condition Raw, mice cumulative coefficient 5, the weak cumulative toxicity in position.
Three, irritation test
1, healthy white rabbit 4 is selected, body weight 2.5-3.0kg, the depilation of family's rabbit back spinal column both sides is respectively 3.0cm × 3.0cm, does not damage epidermis, after 24 hours, by the stock solution uniform application of disinfectant solution of the present invention for 0.2ml on a left side for baring skin Side, right side is not smeared as comparison, after 4 hours, skin wiping is clean, observes dermoreaction, carries out stimulating scoring.
2, result: rabbit baring skin there are no erythema and edema reaction, and skin wound repair integrated value is 0, control sides Skin no abnormality seen, by skin wound repair standards of grading, reaction integral mean value is 0, and disinfectant solution of the present invention is non-stimulated to skin Property.
Four, stability test
Take disinfection solution 50ml of the present invention, after placing 90 days under the conditions of 37 DEG C, for staphylococcus aureus is entered No significant difference is compared before row sterilization, its killing effect and storage.
Five, bacteriostatic test
Below disinfection solution of the present invention is carried out bacteriostatic experiment:
1, experimental strain:
Select the strain that laboratory is representative, staphylococcus aureus, escherichia coli and bacillus pyocyaneus.
2, bacterium culture medium:
Nutrient agar and nutrient broth medium.
3, experiment classification:
Bacteriostatic experiment divides experimental group and matched group, and experimental group selects disinfection solution of the present invention, and matched group selects hypochlorous acid Disinfectant solution.
4, specific experiment step:
(1) preparation of bacterium solution: be inoculated in respectively on three agar culture mediums by above-mentioned three kinds of strains, cultivates 24 at 37 DEG C Hour, during from above-mentioned agar culture medium, picking colonies typical is inoculated in three fresh nutrient broth mediums respectively respectively, Under synthermal, cultivate 18 hours, standby；
(2) take disinfectant solution of the present invention and each 50ml of hypochlorous acid disinfectant solution, be respectively placed in cut-back tank, it is diluted respectively 30 times, above two diluent solution is contained in container respectively, is placed under aseptic condition, standby；
(3) above-mentioned steps (1) is supported the experimental strain of 18 hours through nutrition broth cultivation the dilutest with aseptic nutrient broth Releasing 50 times, every kind of strain is sub-packed in two culture dishs, respectively labelling matched group and experimental group；
(4) dilute solution of the disinfection solution of the present invention of above-mentioned steps (2) gained is respectively dropped into experimental group culture dish, Hypochlorous acid disinfectant solution dilute solution is respectively dropped into matched group culture dish.
5, experimental observation is measured:
Above-mentioned experiment is observed, observes three groups of strains and measure strain revolution mark concrete outcome.
6, after observation is measured, it is placed in above-mentioned culture dish under aseptic condition standing two days, treats that medicament volatilizees completely After, follow the tracks of it has been observed that matched group bacterium colony continues breeding, and experimental group bacterium colony is unchanged.
7, experimental result:
The sterilizing ability of experimental group disinfectant solution of the present invention is much larger than the sterilizing ability of matched group disinfectant solution, and can suppress All kinds of strains continue breeding.

Claims (5)

1. an operating room special sterilizing disinfectant solution, it is characterised in that: make the raw material group of described disinfection solution effective ingredient Become and parts by weight be:
A kind of operating room special sterilizing disinfectant solution the most according to claim 1, it is characterised in that: make described sterilizing The raw material of liquid effective ingredient forms and parts by weight are:
A kind of operating room special sterilizing disinfectant solution the most according to claim 1, it is characterised in that: make described sterilizing The raw material of liquid effective ingredient forms and parts by weight are:
A kind of operating room special sterilizing disinfectant solution the most according to claim 1, it is characterised in that: make described sterilizing The raw material of liquid effective ingredient forms and parts by weight are:
5. the preparation method of operating room special sterilizing disinfectant solution as described in any one of Claims 1 to 4, it is characterised in that: Comprise the following steps that:
(1) Caulis te Folium Callicarpae Longissimae, Folium Pruni pseudocerasi, Cortex seu flos hibisci tiliacei and Amaranthus mangostanus L. are cleaned, chopping, put into container, twist juice, filter impurity, stay juice standby；
(2) Resina garciniae and Herba Houttuyniae are put into container, carry out pulverization process, grind into powder, obtain the fine powder of 180 mesh, standby；
(3) poinsettia is dried in the sun, put into slow fire parch in pot, dry in the air cool, carry out pulverization process, grind into powder, obtained 200 Purpose fine powder, standby；
(4) Herba Centellae, Cortex Magnoliae Officinalis, Herba Beronicastri brunoniani, Herba Rostellulariae and Herba Euphorbiae Helioscopiae are cleaned, put into container, add the distilled water of 8～10 times amount, After soaking 5～6 hours, boil 3～4 hours, extract；Again add 6～8 times amount distilled water, boil 2～3 hours, extract；? After, add 4～6 times amount distilled water, heated and boiled 1～2 hours, extract；Merge three extracting solution, filter, obtain filtrate, standby；
(5) Viola grypoceras A. Gray is cleaned, chopping, put into container, add Mel and stir, stand half an hour, be subsequently adding 3 times amount Distilled water, stir, filter impurity, stay juice standby；
(6) Flos Lonicerae and Radix Achyranthis are cleaned, immerse 3 times amount 60% alcohol solution dipping 1～2 hours, heating extraction 3 is little Time, reclaim ethanol, filter, obtain filtrate, standby；
(7) by Radix Aucklandiae cleaning, drying, mill with stone grinder, mill and add a small amount of water simultaneously, obtain extract, standby；
(8), after the juice obtained by above-mentioned steps (1)～(7), fine powder, filtrate and extract being mixed, 10-12 times amount is added Distilled water, after stirring and dissolving is uniform, heated and boiled 0.5 hour, to less than 60 DEG C, stand 1 hour, filter, obtain filtrate, by filtrate Fill is sealed up for safekeeping, is described operating room special sterilizing disinfectant solution.
CN201610495777.9A 2016-06-21 2016-06-21 A kind of operating room special sterilizing disinfectant solution and preparation method Withdrawn CN106259501A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107802565A (en) * 2017-12-21 2018-03-16 李冬梅 A kind of composite vegetables extractive and its application in cosmetics preservative
CN108812711A (en) * 2018-05-25 2018-11-16 合肥奇呗数字科技有限公司 A kind of preparation method improving sterilizing rate high efficient air purifier
CN108849993A (en) * 2018-08-07 2018-11-23 沂南县迎辉农业开发有限公司 A kind of biological agent and preparation method for preventing and treating mulberry tree powdery mildew

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107802565A (en) * 2017-12-21 2018-03-16 李冬梅 A kind of composite vegetables extractive and its application in cosmetics preservative
CN108812711A (en) * 2018-05-25 2018-11-16 合肥奇呗数字科技有限公司 A kind of preparation method improving sterilizing rate high efficient air purifier
CN108849993A (en) * 2018-08-07 2018-11-23 沂南县迎辉农业开发有限公司 A kind of biological agent and preparation method for preventing and treating mulberry tree powdery mildew

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Address after: 518000 Shenzhen People's Hospital, Shenzhen, Guangdong, 1017 East Gate North Road, Luohu District.

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Application publication date: 20170104