CN102247442B - Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof - Google Patents
Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition with mosquito repelling and itching relieving efficacies, and a preparation method thereof. The composition is prepared from raw medicines of, by weight: 30 to 50 parts of salvia miltiorrhiza, 15 to 25 parts of clove, 15 to 25 parts of radix astragali mongolici, 15 to 25 parts of honeysuckle flower, and 6 to 10 parts of wild dendranthema flower. According to the method provided by the present invention for preparing a Chinese herbal medicine extract, the extraction and separation method is simple, extraction rate of active components through ultrasonic and backflow extractions is high, product purity is high, and product quality is greatly improved. The traditional Chinese medicine components have functions of bacteria inhibiting, virus resisting, inflammation resisting, heat relieving, pain relieving, immune function regulating, sweat secretion inhibiting, skin soothing, and the like. Therefore, the extract have good efficacies as a mosquito repellant. The extract is widely applied in the preparation of ideal mosquito repelling floral water. As a result of experiments, the preparation has no toxic or side-effect, and is suitable for infants and children.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition with mosquito-expelling and antipruritic effect reaches the Chinese medicine for external application that is prepared by said composition.
Background technology
Human body skin is realized perspire by common sweat gland and special sweat gland.Common sweat gland is distributed in whole skin, and special sweat gland is called again scent gland, only is distributed in specific part.Common perspiration mainly contains salinity and a small amount of organic substance, and special perspiration contains lipoids and fatty acid.No matter be common perspiration or special perspiration, do not contain odoriferous substance during discharge, it just can generate the volatile chemical substance after only having the microorganism that is existed by skin surface to decompose.Typical stink with perspiration is by multiple compounds, causes such as the carbon carboxylic acid (C4～11) of saturated, unsaturated side chain and terminal unsaturation.Female mosquitoes need to be sucked blood and be laid eggs, educates ovum, and it has a sharp sense of smell, and the volatile matter such as the carbon dioxide that human body respiration and metabolism are produced and lactic acid is very responsive, can directly rush at the object of sucking blood outside 30m, Here it is mosquito bite people's main cause.Mosquito in order to prevent blood coagulation, after stining people and animals, can be injected some salivas at wound when biting, pathogen is just propagated thus.In the Asia, Africa and America, annually surpass 1,000,000 because of the female malaria mosquito bite dead number of being infected with malaria.Summer, mosquito bite had a strong impact on sleep, infant particularly, not only impact sleep, therefore PI various diseases is also paid close attention to by people extensively, at present to the product of the repellent of mosquito, mosquito repellent product on the market contains the chemosynthesis compositions such as diethyltoluamide more, skin there is very large zest, health is also had certain side effect, especially be not suitable for the baby and use.
Summary of the invention
The object of the invention is to propose that a kind of effectively bacteriostasis and sterilization, antiinflammatory are analgesic, the Chinese medicine composition of the skin of releiving, safe anophelifuge.
A further object of the present invention is to propose a kind of extracting method of above-mentioned Chinese medicine composition effective ingredient.
The 3rd purpose of the present invention is to propose to utilize the mosquito repellent of above-mentioned Chinese medicine extract preparation.
Invention thinking of the present invention is: according to the mechanism of anophelifuge, take the Chinese medical science theory as the basis, take skin health as aim, according to monarch, minister, the traditional Chinese medical science prescription thought helping, make, the Radix Salviae Miltiorrhizae of from the natural Chinese medicinal herb plant, selecting, Flos Caryophylli, the Radix Astragali, Flos Lonicerae, Flos Chrysanthemi Indici five tastes Chinese herbal medicine, carry out prescription and extract, the functional component that obtains can sweat secretion, bacteriostasis and sterilization, antiinflammatory be analgesic from suppressing, releive skin and abnormal smells from the patient anophelifuge aspect reach desirable safe repelling effect jointly.
The present invention selects Radix Salviae Miltiorrhizae, Flos Caryophylli, the Radix Astragali, Flos Lonicerae, the combination of Flos Chrysanthemi Indici five tastes Chinese herbal medicine, and each medicine synergism of distinguishing the flavor of effectively plays the effect of mosquito-expelling and antipruritic.The brief introduction of five tastes efficacy of drugs is as follows:
Radix Salviae Miltiorrhizae: nature and flavor are bitter, are slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Cure mainly: menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Flos Caryophylli: nature and flavor are hot, and temperature is returned bright, the shaoyin channel of lunar, the sufficient sun of hands.Effect: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.
The Radix Astragali: contain sucrose, glucuronic acid, astragalus polysaccharides A, B, C, D, lymphatic temperament, several amino acids, bitter principle, Radix Astragali saponin, choline, folic acid, flavane chemical compound and contain the various trace elements such as selenium, silicon, zinc, cobalt, copper, molybdenum.Nature and flavor: sweet, tepor.Return lung, spleen, liver, kidney channel.The Radix Astragali has benefiting QI for strengthening the superficies, arresting sweating admittedly to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Flos Lonicerae: sweet in the mouth; Cold.Return lung; The stomach warp.Effect: heat-clearing and toxic substances removing.The epidemic febrile disease heating; Toxic-heat and blood stasis; The carbuncle furuncle; Sore throat and multi-infection disease.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, suffering.Effect: heat-clearing and toxic substances removing; The dispelling wind suppressing the hyperactive liver.Cure mainly: furuncle; Carbuncle; Erysipelas; Eczema; Dermatitis; Anemopyretic cold; Laryngopharynx swelling and pain; Hypertension.
In the present invention prescription, Radix Salviae Miltiorrhizae has and improves that blood microcirculation, anti-inflammation detumescence are antipruritic, the effect of the skin of releiving; Flos Caryophylli, Flos Lonicerae play bacteriostasis and sterilization, anti-inflammatory and antalgic is antipruritic, abnormal smells from the patient is walked quickly and kept away mosquito effect; Flos Chrysanthemi Indici plays anti-inflammation, heat clearing away, abnormal smells from the patient and walks quickly and keeps away the effect of mosquito; The Radix Astragali mainly works skin sweat secretion, the effect of invigorating QI to consolidate the body surface resistance of suppressing.Chinese medicine of the five flavours is worked in coordination with onset, extracts the functional component obtain through specific process and has no side effect, can sweat secretion, bacteriostasis and sterilization, antiinflammatory are analgesic from suppressing, releive skin and abnormal smells from the patient anophelifuge aspect reach desirable safe repelling effect jointly.
Concrete technical scheme of the present invention is as follows:
A kind of Chinese medicine composition with mosquito-expelling and antipruritic effect, described compositions is made by the crude drug of following weight portion proportioning:
Radix Salviae Miltiorrhizae 30～50 weight portions, Flos Caryophylli 15～25 weight portions, the Radix Astragali 15～25 weight portions, Flos Lonicerae 15～25 weight portions, Flos Chrysanthemi Indici 6～10 weight portions.
Each crude drug optimum weight part ratio of described compositions is:
Radix Salviae Miltiorrhizae 40 weight portions, Flos Caryophylli 18 weight portions, the Radix Astragali 18 weight portions, Flos Lonicerae 18 weight portions, Flos Chrysanthemi Indici 6 weight portions.
A kind of Chinese medicine extract with mosquito-expelling and antipruritic effect, described extract are extracted through the conventional extracting method of Chinese materia medica by above-mentioned compositions and obtain.
A kind of preparation method of above-mentioned Chinese medicine composition, concrete steps are as follows:
(1) takes by weighing each crude drug according to said ratio;
(2) crude drug being added percent by volume is the ultrasonic pretreatment of 50%～80% ethanol, and the mass volume ratio of crude drug and ethanol (g/mL) is 1: 20～30, and ultrasonic pretreatment time is 30～50min;
Described ultrasonic pretreated ultrasonic frequency 50kHz, power 160W;
(3) ultrasonic pretreatment post-heating stirring and refluxing is extracted;
(4) be cooled to 45～50 ℃; Fine straining after the coarse filtration, gained filtrate is Chinese medicine extract of the present invention.
The percent by volume of ethanol is 60% in the described step (2), and the mass volume ratio of crude drug and ethanol (g/mL) is 1: 30, and ultrasonic pretreatment time is 30min.
Heated and stirred reflux, extract, in the described step (3): be heated to 45～60 ℃, stirring and refluxing is extracted 45～60min, reclaims extracting solution; Reflux, extract, for the second time, the mass volume ratio of crude drug and ethanol (g/mL) is 1: 20,45～60 ℃, stirring and refluxing is extracted 45～60min, stopped heating, collection extracted twice liquid.
Be cooled to 50 ℃ in the described step (4), the used gauze of coarse filtration is 100～200 orders, and fine straining is selected filter cake (800～1250 order) or 3～5 μ m filter paper filterings.
The purposes of the Chinese medicine extract of said method preparation in preparation mosquito-expelling and antipruritic preparation.
A kind of external preparation with mosquito-expelling and antipruritic effect, it is to utilize on Chinese medicine extract that said method prepares and the pharmaceutics acceptable adjuvant to make.
Different according to the use approach, the present composition is made external preparation, such as external spraying agent, unguentum, liniment or distillate medicinal water etc.But be not limited to above-mentioned dosage form, can be according to known method in form of Chinese drug and the skin care item industrial circle, aforementioned pharmaceutical compositions is made various external preparation after by the known method degerming.
Preparation of the present invention, its usage and consumption are as follows:
Method: get respectively approximately 4g of mosquito-driving condensation dew, evenly be applied to baring skin, smear 1 time every 1h.
Consumption: mosquito-driving condensation dew approximately 4g/ time.
Beneficial effect of the present invention:
The method for preparing Chinese herbal medicine extract provided by the invention, extraction separation method is easy, and effective component extraction rate is high after the ultrasonic and reflux, extract,, and products obtained therefrom purity is higher, and product quality has had very large improvement.Since Chinese prescription itself have inhibitory anti-virus, antiinflammatory antipyretic-antalgic antipruritic, regulate immunologic function, suppress sweat secretion, the effect such as the skin function of releiving, therefore its extract has good effect as mosquito-repellent, have in the desirable mosquito repelling effect floral water in preparation, has extensive use, through experiment confirm, the present invention has no side effect to human body, and baby and child all can use.
Description of drawings
Fig. 1 is the repelling effect figure that laboratory test methods is measured 50% concentration extracting solution;
Fig. 2 is that field testing procedure is measured 50% concentration extracting solution and long-acting mosquito-driving frost usability comparison diagram;
Fig. 3 is that field testing procedure is measured 50% concentration extracting solution and long-acting mosquito-driving frost usability comparison diagram.
The specific embodiment
The used medical material of the present embodiment all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.
The preparation of embodiment 1 Chinese medicine extract of the present invention
(1) takes by weighing each crude drug according to following proportioning;
Radix Salviae Miltiorrhizae 20g, Flos Caryophylli 9g, Radix Astragali 9g, Flos Lonicerae 9g, Flos Chrysanthemi Indici 3g.
(2) crude drug being added percent by volume is the ultrasonic pretreatment of 60% ethanol, and the mass volume ratio of crude drug and ethanol (g/mL) is 1: 30, namely adds 1500mL ethanol, and ultrasonic pretreatment time is 30min; Described ultrasonic pretreated ultrasonic frequency 50kHz, power 160W;
(3) ultrasonic pretreatment post-heating stirring and refluxing is extracted; Be heated to 50 ℃, stirring and refluxing is extracted 60min, reclaims extracting solution; Reflux, extract, for the second time, the mass volume ratio of crude drug and ethanol (g/mL) is 1: 20,50 ℃, stirring and refluxing is extracted 60min, stopped heating, collection extracted twice liquid;
(4) be cooled to 45 ℃; Fine straining after the coarse filtration, the used gauze of coarse filtration is 200 orders, and fine straining is selected cake filtration (available from the sensible filter material device factory of Tianjin Dongli District, 800～1000 orders), and gained filtrate is Chinese medicine extract of the present invention.
The sucking filtration rear filtrate is measured pH value, solid content, and measurement result is: pH value is 6.0～7.0, solid content is 15～25%; 85 ℃ are incubated 30 minutes afterwards, and water-bath is cooled to room temperature, obtains product.Afterwards as required, can carry out subsequent operation, such as cask washing, sterilization, fill, code is beaten in vanning, warehouse-in.
The preparation of embodiment 2 Chinese medicine extract of the present invention
(1) takes by weighing each crude drug according to following proportioning;
Radix Salviae Miltiorrhizae 50g, Flos Caryophylli 25g, Radix Astragali 15g, Flos Lonicerae 15g, Flos Chrysanthemi Indici 10g.
(2) crude drug being added percent by volume is the ultrasonic pretreatment of 50% ethanol, and the mass volume ratio of crude drug and ethanol (g/mL) is 1: 20, namely adds 2300mL ethanol, and ultrasonic pretreatment time is 40min; Described ultrasonic pretreated ultrasonic frequency 50kHz, power 160W;
(3) ultrasonic pretreatment post-heating stirring and refluxing is extracted; Be heated to 45 ℃, stirring and refluxing is extracted 50min, reclaims extracting solution; Reflux, extract, for the second time, the mass volume ratio of crude drug and ethanol (g/mL) is 1: 30,45 ℃, stirring and refluxing is extracted 50min, stopped heating, collection extracted twice liquid;
(4) be cooled to 50 ℃; Fine straining after the coarse filtration, the used gauze of coarse filtration is 100 orders, and fine straining is selected 3～5 μ m filter paper filterings, and gained filtrate is Chinese medicine extract of the present invention.
The sucking filtration rear filtrate is measured pH value, solid content, and measurement result is: pH value is 6.0～7.0, solid content is 20～25%; 85 ℃ are incubated 30 minutes afterwards, and water-bath is cooled to room temperature, obtains product.Afterwards as required, can carry out subsequent operation, such as cask washing, sterilization, fill, code is beaten in vanning, warehouse-in.
The preparation of embodiment 3 Chinese medicine extract of the present invention
(1) takes by weighing each crude drug according to following proportioning;
Radix Salviae Miltiorrhizae 30g, Flos Caryophylli 15g, Radix Astragali 25g, Flos Lonicerae 25g, Flos Chrysanthemi Indici 8g.
(2) crude drug being added percent by volume is the ultrasonic pretreatment of 50% ethanol, and the mass volume ratio of crude drug and ethanol (g/mL) is 1: 25, namely adds 2575mL ethanol, and ultrasonic pretreatment time is 50min; Described ultrasonic pretreated ultrasonic frequency 50kHz, power 160W;
(3) ultrasonic pretreatment post-heating stirring and refluxing is extracted; Be heated to 60 ℃, stirring and refluxing is extracted 60min, reclaims extracting solution; Reflux, extract, for the second time, the mass volume ratio of crude drug and ethanol (g/mL) is 1: 25,60 ℃, stirring and refluxing is extracted 60min, stopped heating, collection extracted twice liquid;
(4) be cooled to 50 ℃; Fine straining after the coarse filtration, the used gauze of coarse filtration is 200 orders, and fine straining is selected 3～5 μ m filter paper filterings, and gained filtrate is Chinese medicine extract of the present invention.
The sucking filtration rear filtrate is measured pH value, solid content, and measurement result is: pH value is 6.0～7.0, solid content is 15～20%; 85 ℃ are incubated 30 minutes afterwards, and water-bath is cooled to room temperature, obtains product.Afterwards as required, can carry out subsequent operation, such as cask washing, sterilization, fill, code is beaten in vanning, warehouse-in.
The preparation of embodiment 4 mosquito-repellent perfumes of the present invention
Raw material and proportioning (mass percent):
Preparation method: mosquito-repellent perfume
| Title | Addition |
| Ethanol | 70.0％ |
| The Chinese medicine extract of embodiment 2 preparations | 10.0％ |
| Essence | 2.0％ |
| Trehalose | 1.0％ |
| Pantothenylol | 0.3％ |
| Sodium citrate | 0.2％ |
| Citric acid | 0.1％ |
| Antiseptic | 0.1％ |
| Deionized water | To 100 |
Technique:
1) the raw material dose and method according to embodiment 2 prepares Chinese medicine extract;
2) with stirring and dissolving behind the water-soluble post-heating to 80 of trehalose ℃, cool to the extract that adds pantothenylol and embodiment 1 preparation below 50 ℃;
3) temperature be down to add ethanol, essence, sodium citrate and citric acid below 45 ℃, antiseptic stirs and gets final product.
The preparation of embodiment 5 mosquito-driving condensation dews of the present invention
Mosquito-driving condensation dew: (can not add essence and antiseptic in the infant formula)
Technique:
1) the raw material dose and method according to embodiment 1 prepares Chinese medicine extract;
2) the AVC rear adding glycerol that is uniformly dispersed soluble in water, trehalose, α-mannan, allantoin are stirred, be heated to 80 ℃ after insulation 30min sterilization;
3) cool to adding pantothenylol and Chinese medicinal herb repellent liquid below 50 ℃;
4) temperature is down to and is added hyaluronate sodium, essence, antiseptic below 45 ℃ and stir and get final product.
The Chinese medicine extract efficacy test
1, laboratory test is measured
Test method is carried out measure of merit among the method employing GB/17322.10-1988.
The attack test: growing * wide * it is high that experimenter's arm exposes 4cm * 4cm skin area in order to put into 300 examination worms in the mosquito cage of 40cm * 30cm * 30cm, and remainder tightly covers.Arm stretched in the mosquito cage place 2min, the mosquito number that record comes to stop falling,＞30 persons be that attack is qualified, this testing crew and this cage mosquito can be used for repellent and test.
Repellency test: select the qualified experimenter of attack, respectively expose as mentioned above the skin area of 4cm * 4cm on its both hands arm, wherein an arm is made as blank, does not do any smearing; Another arm expose portion is pressed 1.5mg/cm
2Dosage evenly smear repellant.After smearing 2h, arm is stretched into 2min in the qualified mosquito cage of attack, observe and to have or not mosquito to come to suck blood, per hour test afterwards 1 time, make repellant and lost efficacy as long as have mosquito to come to suck blood namely to declare.The effective protecting time (h) of record repellant.A prescription repeated trials 10 times.
Effective Vate of Protection (%)=[(matched group is on average stung thorn number-test group and on average stung the thorn number)/matched group is on average stung the thorn number] * 100
Laboratory test results is seen Fig. 1.As shown in Figure 1, Chinese medicine extract of the present invention (embodiment 1 preparation) concentration Effective Vate of Protection＞80% 50% time, average repellent effect is at 12h.Illustrate that Chinese medicine extract provided by the invention has very good repellent worm effect.
2, field trial is measured
The method is carried out according to the method that provides such as Publication about Document: Wang Jun, and Zhao Fan etc., 22 kinds of prescription repellant repelling effects are observed, Chinese media biology and control magazine, 2010,21 (3): 245-247.
Specimen and grouping: (1) blank group: blank condensation (replacing repellant with water); (2) positive controls: long-acting mosquito-driving frost; (3) sampling test group: the Chinese medicine extract of 50% concentration of volume percent is according to the method for embodiment 5 and the mosquito-driving condensation dew of consumption preparation.Wherein, the long-acting mosquito-driving frost consists of carbomer 0.6%, hydroxypropyl emthylcellulose 0.2%, ethanol 30%, dimethyl phthalate 10%, Icaridin 20%, water-soluble silicon oil 5%, diisopropylamine 0.4%, deionized water 33.8%.
The test grouping, every group of 10 people (wherein 1 people is responsive body constitution), test specimen is distributed to the experimenter at random, and the experimenter all wears the robe trousers, and the left lower limb bottom of s trouser leg has been drawn, get respectively approximately 4g of mosquito-driving condensation dew, evenly be applied to the following ankle joint of left lower limb knee joint with the upper part, keep the coating position always exposed, every 1h intensive place of mosquito in outdoor grove 15min that stands, observe at any time the mosquito bite situation, the time bitten in record.Annotate: the average guard time of blank group is 0.1h.
Evaluation methodology: take time that biting for the 1st time appears in exposed part as record index, adopt the method for the comprehensive gradings such as guard time, comfort [good (2), general (1), uncomfortable (0)], ease of use [good (2), general (1), uncomfortable (0)], untoward reaction [(1) is arranged, without (0)] to estimate.
Effective Vate of Protection (%)=[(matched group is on average stung thorn number-test group and on average stung the thorn number)/matched group is on average stung the thorn number] * 100.Statistical disposition adopts the t check to carry out statistical analysis.
This experimental result is shown in Fig. 2,3, and as seen from the figure, this extracts of Chinese herbal medicine effective protecting time, Effective Vate of Protection and use comfort and convenient are also more desirable than positive controls, but the two difference not statistically significant.50% concentration extracting solution can keep the Effective Vate of Protection more than 90%, and the repellent time is 10h, proves that Chinese medicine extract provided by the invention has the ability of stronger mosquito repellent.The experimenter is all without allergic symptom, and allergic symptom does not occur the experimenter of responsive body constitution yet.Mosquito-expelling and antipruritic extract of the present invention is pure plant component, and the condensation character of preparation is gentle, has no irritating odor, and is fit to baby, anemia of pregnant woman and old people and uses.Extract of the present invention can be used for preparing the mosquito repellent products such as floral water, especially is used for preparing mosquito-driving condensation dew with desirable repelling effect or floral water etc.
Claims (9)
1. the Chinese medicine composition with mosquito-expelling and antipruritic effect is characterized in that, described compositions is made by the crude drug of following weight portion proportioning:
Radix Salviae Miltiorrhizae 30～50 weight portions, Flos Caryophylli 15～25 weight portions, the Radix Astragali 15～25 weight portions, Flos Lonicerae 15～25 weight portions, Flos Chrysanthemi Indici 6～10 weight portions.
2. Chinese medicine composition according to claim 1 is characterized in that, described compositions is made by the crude drug of following weight portion proportioning:
Radix Salviae Miltiorrhizae 40 weight portions, Flos Caryophylli 18 weight portions, the Radix Astragali 18 weight portions, Flos Lonicerae 18 weight portions, Flos Chrysanthemi Indici 6 weight portions.
3. the Chinese medicine extract with mosquito-expelling and antipruritic effect is characterized in that, described extract is extracted through the conventional extracting method of Chinese materia medica by claim 1 or 2 described compositionss and obtains.
4. the preparation method of a claim 1 or 2 described Chinese medicine compositions is characterized in that, concrete steps are as follows:
(1) proportioning according to claim 1 or 2 takes by weighing each crude drug;
(2) crude drug being added percent by volume is the ultrasonic pretreatment of 50%～80% ethanol, and the mass volume ratio g/mL of crude drug and ethanol is 1:20～30, and ultrasonic pretreatment time is 30～50min; Described ultrasonic pretreated ultrasonic frequency 50kHz, power 160W;
(3) ultrasonic pretreatment post-heating stirring and refluxing is extracted: be heated to 45～60 ℃, stirring and refluxing is extracted 45～60min, reclaims extracting solution; Reflux, extract, for the second time, the mass volume ratio g/mL of crude drug and ethanol is 1:20～30,45～60 ℃, stirring and refluxing is extracted 45～60min, stopped heating, collection extracted twice liquid;
(4) be cooled to 45～50 ℃; Filter, gained filtrate is Chinese medicine extract.
5. the preparation method of Chinese medicine composition according to claim 4 is characterized in that, the percent by volume of ethanol is 60% in the described step (2), and the mass volume ratio g/mL of crude drug and ethanol is 1:30, and ultrasonic pretreatment time is 30min.
6. the preparation method of Chinese medicine composition according to claim 4 is characterized in that, is cooled to 50 ℃ in the described step (4), filters: 100～200 orders filter first, again with filter cake or 3～5 μ m filter paper filterings.
7. the purposes of the Chinese medicine extract that any one prepares in the claim 4 to 6 in preparation mosquito-expelling and antipruritic preparation.
8. purposes according to claim 7 is characterized in that, described preparation is spray, unguentum, liniment or distillate medicinal water.
9. external preparation with mosquito-expelling and antipruritic effect, it is to utilize on the described method of any one prepares in the claim 4 to 6 Chinese medicine extract and the pharmaceutics acceptable adjuvant to make.
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| CN103655718B (en) * | 2012-08-30 | 2015-02-18 | 北京妙心堂医药科技有限公司 | Traditional Chinese medicine composition, preparation, and floral water and application method thereof |
| CN102846517B (en) * | 2012-09-26 | 2013-09-11 | 王强 | Traditional Chinese medicine composition capable of removing miliaria and relieving itching as well as cosmetic containing traditional Chinese medicine composition |
| CN105326746A (en) * | 2015-11-20 | 2016-02-17 | 陈倚华 | Mosquito repellent for children and preparation method of mosquito repellent |
| CN106138241B (en) * | 2016-08-22 | 2018-11-20 | 雷允上药业集团有限公司 | A kind of Chinese medicine composition and preparation method thereof for relieving itching and eliminating swelling after bite by mosquitos |
| CN107232187A (en) * | 2017-06-23 | 2017-10-10 | 骆琦 | Careless plant mosquito-repellent spray liquid of one kind hundred and preparation method thereof |
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| CN102068498A (en) * | 2010-11-26 | 2011-05-25 | 新时代健康产业（集团）有限公司 | Chinese medicinal composition with acne treatment and anti-inflammation effects, preparation and preparation method thereof |
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| CN102068498A (en) * | 2010-11-26 | 2011-05-25 | 新时代健康产业（集团）有限公司 | Chinese medicinal composition with acne treatment and anti-inflammation effects, preparation and preparation method thereof |
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Effective date of registration: 20160324 Address after: 101200, No. 3, M2-5 District, Hing Valley Economic Development Zone, Pinggu District, Beijing Patentee after: Beijing Orient Miao Sen bio tech ltd Address before: 100048 Beijing City, Haidian District, office building No. 21 room 1017 Patentee before: Beijing Huaxia Zhongfang Biological Technology Co.,Ltd. |