CN106138241B - A kind of Chinese medicine composition and preparation method thereof for relieving itching and eliminating swelling after bite by mosquitos - Google Patents
A kind of Chinese medicine composition and preparation method thereof for relieving itching and eliminating swelling after bite by mosquitos Download PDFInfo
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- CN106138241B CN106138241B CN201610700793.7A CN201610700793A CN106138241B CN 106138241 B CN106138241 B CN 106138241B CN 201610700793 A CN201610700793 A CN 201610700793A CN 106138241 B CN106138241 B CN 106138241B
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Abstract
The Chinese medicine composition and preparation method thereof that the invention discloses a kind of for relieving itching and eliminating swelling after bite by mosquitos, it is made of the bulk pharmaceutical chemicals of following parts by weight：30~80 parts of Radix Astragali, 1~10 part of cow-bezoar, 20~60 parts of Sculellaria barbata, 30~60 parts of Radix Glycyrrhizae, 30~70 parts of the fruit of summer cypress, 20~60 parts of kuh-seng, 30~60 parts of cortex cinnamomi, 20~60 parts of cloves.Chinese medicine composition prescription science provided by the invention, the Chinese materia medica preparation and floral water being prepared have no toxic side effect, with strong points using pure natural formula.The preparation for treating bite by mosquitos total effective rates 95% such as the floral water of the traditional chinese medicine composition of the invention preparation, itch caused by bite by mosquitos, hot pain symptom can be eliminated by averagely smearing 5 minutes, can eliminate within 30 minutes redness, and curative effect is reliable, quick.Adult, children can be used, securely and reliably.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, are specifically related to a kind of Chinese traditional medicine composition for relieving itching and eliminating swelling after bite by mosquitos
Object and preparation method thereof.
Background technique
Mosquito spp Insecta Diptera Dulicidae is a kind of fine winged insect with sucking mouth parts, and the female mosquito sucked blood is to step on
Remove from office the vector of the other pathogens such as heat, malaria, yellow fever, filariasis, encephalitis B.There are many Mosquito species, it is known that the world
On have more than 3000 kinds, China has found more than 300, mainly Anopheles sinensis Anopheleshyrcanus sinensis, light color
Culex Culex pipiens pallens and aedes albopictus Aedes albopictus three classes.
Mosquito bite dermatitis (Mosquito-bite dermatitis, MBD), is the allergic dermatitis as caused by bite by mosquitos
Disease is the main Types of insect dermatitis.Mosquito stabs skin by its mouthpart, and saliva or venom invade skin, into human body
Cause inflammatory reaction after skin, red and swollen, heat pain, itching occurs, it is serious anti-that one or two people locally generate bleb, hemorrhagic necrosis etc.
It answers.
Redness, heat pain and the Itching conditions that summer is difficult to avoid that by bite by mosquitos, but is occurred after bite by mosquitos
Quickly eliminate is still a problem.The drug for being currently used for bite by mosquitos relieving itching and eliminating swelling is mostly antiallergy, steroids Western medicine, such as benzene
Extra large Lamine, Compound Dexamethasone Acetate etc., long-time service can not only develop drug resistance, it is also possible to make surface of a wound pigmentation, and then cause the surface of a wound
The side effects such as atrophoderma, secondary infection, children need to be used with caution.Or with alkaline matter, neutralized such as suds, sodium bicarbonate or ammonium hydroxide
The acid venom of mosquito mitigates red and swollen, while biting place with scourings such as floral water come antipruritic, but effect is unobvious.
Floral water currently on the market is various, but its traditional raw material is dimethyl phthalate, alcohol, menthol, borneol, musk deer
Vanilla phenol, camphor, essence, alcohol and deionized water, except have the function of it is refrigerant, dispel in addition to miliaria, for worm caused by bite by mosquitos
It is little to sting dermatitis effects.Dimethyl phthalate contained by floral water have certain toxicity, in use, people by alimentary canal,
Respiratory tract absorbs the dimethyl phthalate of part, can not only induce the diseases such as asthma, long-time service can also carcinogenic, teratogenesis.Some liquid distilled from honeysuckle flowers or lotus leaves
Water is in order to achieve the effect that anti-inflammatory, usually addition salicylic acid compounds, but salicylic acid compounds permeability is excessively high, not only
Skin can be stimulated, can also to have dry skin.In addition, many floral water containing menthol, often cause people's skin
Irritability reaction.
Scytitis caused by bite by mosquitos belongs to " disliking sting " scope in traditional Chinese medicine.Motherland's medicine thinks to be venom
Invade skin, injure channels, channels stasis blocking, QI-blood circulation is unsmooth, it is strongly fragrant and change heat caused by.Main pathological change is poison, the stasis of blood, heat.
Treatment is worked as with anti-evil, the clearing heat and detoxicating, disperse blood stasis and dredge collateral of solid table, dispelling wind and arresting itching for the basic rules for the treatment of.
Documents：A kind of Chinese medicine composition, preparation, floral water and its application method (number of patent application：
201210315409.3) patent of invention discloses a kind of pure plant flowers Chinese medicine composition for mosquito-expelling and antipruritic, system
Agent and floral water and its application method.The Chinese medicine composition include Radix Salviae Miltiorrhizae, peppermint, cow-bezoar, safflower, honeysuckle, wild chrysanthemum,
Cortex dictamni, Radix Astragali, cloves, kuh-seng, Chinese trumpet creeper, purslane etc., the Chinese materia medica preparation and floral water master that thus composition is prepared
It is used for mosquito-expelling and antipruritic.The invention is applied to bite by mosquitos patient, and average 8 minutes antipruritic, could reduce swelling within 1 day, antipruritic and detumescence
Time is longer, it is therefore necessary to invent a kind of reduce swelling and antipruritic effect more preferably Chinese medicine composition.
Summary of the invention
Goal of the invention：Mosquito is efficiently and safely used for present invention aims to solve the deficiencies of the prior art, and provides a kind of a kind of
Bite the Chinese medicine composition and preparation method thereof of repellent antipruritic.Prescription of the present invention on the basis of existing technology, passes through a large amount of realities
Screening flavour of a drug are tested, choosing Sculellaria barbata, Radix Glycyrrhizae, the fruit of summer cypress, cortex cinnamomi is raw material, and full side is the section carried out based on traditional Chinese medical theory
Prescription, rather than the simple combination of effect flavour of a drug.Radix Astragali consolidates the anti-heresy of table in side, is monarch drug in a prescription；Cow-bezoar and Sculellaria barbata are clearing heat and detoxicating,
The fruit of summer cypress and kuh-seng antipyretic and itching-stopping are altogether ministerial drug；Cortex cinnamomi and cloves fragrance are walked to alter, and are altogether adjutant, Radix Glycyrrhizae tool hundred poisoning of druies of solution, as
Make medicine.The clearing heat and detoxicating, repellent antipruritic in full side.And the present invention using different extracting methods and is adopted according to each medicinal material property of prescription
With techniques such as macroporous resin purifications, the Chinese materia medica preparation and floral water being prepared are in the quick repellent antipruritic side for bite by mosquitos
Face significant effect, the experimental results showed that：Itch caused by bite by mosquitos, hot pain symptom can be eliminated for 5 minutes by averagely smearing, and 30 points
Clock can eliminate redness, have the advantages such as rapid-action, without side-effects, easy to use.
Technical solution：In order to achieve the goal above, the technical scheme adopted by the invention is as follows：
A kind of Chinese medicine composition for relieving itching and eliminating swelling after bite by mosquitos, it is made by the bulk pharmaceutical chemicals of following parts by weight：
30~80 parts of Radix Astragali, 1~10 part of cow-bezoar, 20~60 parts of Sculellaria barbata, 30~60 parts of Radix Glycyrrhizae, 30~70 parts of the fruit of summer cypress,
20~60 parts of kuh-seng, 30~60 parts of cortex cinnamomi, 20~60 parts of cloves.
Wherein cow-bezoar can be replaced with calculus bovis factitius or In vitro cultured Calculus Bovis.
Preferably, the above-described Chinese medicine composition for relieving itching and eliminating swelling after bite by mosquitos, it is by following heavy
The bulk pharmaceutical chemicals for measuring number are made：
50 parts of Radix Astragali, 6 parts of cow-bezoar, 40 parts of Sculellaria barbata, 50 parts of Radix Glycyrrhizae, 50 parts of the fruit of summer cypress, 40 parts of kuh-seng, 50 parts of cortex cinnamomi, fourth
It is 50 parts fragrant.
Preferably, the above-described Chinese medicine composition for relieving itching and eliminating swelling after bite by mosquitos, it is by following heavy
The bulk pharmaceutical chemicals for measuring number are made：
30 parts of Radix Astragali, 1 part of cow-bezoar, 20 parts of Sculellaria barbata, 30 parts of Radix Glycyrrhizae, 30 parts of the fruit of summer cypress, 20 parts of kuh-seng, 30 parts of cortex cinnamomi, fourth
It is 20 parts fragrant.
Preferably, the above-described Chinese medicine composition for relieving itching and eliminating swelling after bite by mosquitos, it is by following heavy
The bulk pharmaceutical chemicals for measuring number are made：
80 parts of Radix Astragali, 10 parts of cow-bezoar, 60 parts of Sculellaria barbata, 60 parts of Radix Glycyrrhizae, 70 parts of the fruit of summer cypress, 60 parts of kuh-seng, 60 parts of cortex cinnamomi, fourth
It is 60 parts fragrant.
Preferably, the above-described Chinese medicine composition for relieving itching and eliminating swelling after bite by mosquitos, the cow-bezoar
For natural ox gallstone or calculus bovis factitius.
Preparation method of the present invention for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, it includes following step
Suddenly：
A：Radix Astragali, Radix Glycyrrhizae and Sculellaria barbata are taken in parts by weight, and Radix Astragali, Radix Glycyrrhizae and three taste Chinese medicine of Sculellaria barbata are ground into slightly
Powder adds ethyl alcohol, and heating and refluxing extraction filters, combined extract, and filtrate concentration obtains medical fluid A；
B：The fruit of summer cypress and kuh-seng are taken in parts by weight, the fruit of summer cypress and kuh-seng are added water to cook, and are filtered, combined extract, it will
Filtrate decompression concentration, is cooled to room temperature, and ethyl alcohol is added, agitates by adding, makes to mix well, and stands, sediment is filtered out, by filtrate
Recycling ethyl alcohol is simultaneously concentrated into medicinal extract, and ethyl alcohol is added, and heating dissolves medicinal extract, dissolved solution is stood, sediment is filtered out, is obtained
To medical liquid B；
C：Upper large pore resin absorption column after the medical fluid A that step A is obtained and the medical liquid B that step B is obtained are mixed, standing adsorption
Afterwards, be washed with deionized water take off to eluent be it is colourless, discard eluent, being then eluted to eluent with the alcohol of low concentration C1~3 is
Light color discards eluent, then is eluted with the alcohol of high concentration C1~3, collects eluent, and eluent, which is recovered under reduced pressure, removes the alcohol of C1~3, dense
Contracting, obtains medical fluid C；
D：Cortex cinnamomi and cloves are taken in parts by weight, using extraction by steam distillation, obtain extractive of volatile oil；
E：The medical fluid C that step C is obtained and the extractive of volatile oil that step D is obtained are mixed, in parts by weight addition cow-bezoar,
Mix to get.
Preferably, the preparation method for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, it is wrapped
Include following steps：
Step A：Radix Astragali, Radix Glycyrrhizae and Sculellaria barbata are taken in parts by weight, and Radix Astragali, Radix Glycyrrhizae and three taste of Sculellaria barbata are ground into slightly
Powder adds such as 30%~80% ethyl alcohol of volumetric concentration, and heating and refluxing extraction 1~3 time, each ethyl alcohol volumetric usage is medicinal material weight
4~10 times amount, 1~3 hour every time, filter and merge No. 1~3 extracting solution, be concentrated into 0.25~5g crude drug/mL medical fluid A；
Step B：The fruit of summer cypress and kuh-seng are taken in parts by weight, the fruit of summer cypress and kuh-seng are added water to cook 1~3 time, every time plus water
Volume is 2~10 times of medicinal material weight, 1~3 hour every time, filters and merges No. 1~3 extracting solution, filtrate decompression is concentrated
To the 1/3~1/2 of original volume, it is cooled to room temperature, the 60%-95% ethyl alcohol of 1~3 times of volume is added, agitates by adding, make sufficiently
Mix, stand 12~36 hours, filter out sediment, by filtrate recycling ethanol and be concentrated into 50 DEG C of relative densities be 1.20~1.40
Thick shape medicinal extract, add 20%~60% ethyl alcohol, heating dissolves medicinal extract, dissolved solution is stood 12~36 hours,
Sediment is filtered out, medical liquid B is obtained；
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water de-
To eluent be it is colourless, discard eluent, it is light color that the alcohol of the C1 for being then 5~30% with concentration~3, which is eluted to eluent, is discarded
Eluent, then the alcohol of C1~3 for being 40%~95% with concentration elute, and collect eluent, eluent decompression, and recycling removes C1~3
Alcohol is concentrated into 0.5~3g crude drug/mL medical fluid C；
Step D：Cortex cinnamomi, cloves are taken in parts by weight, the water of 8~15 times of volumes of medicinal material weight are added, using vapor
The way of distillation is extracted, and extractive of volatile oil is obtained；
Step E：The medical fluid C that step C is obtained and the extractive of volatile oil that step D is obtained are mixed, are added in parts by weight
Cow-bezoar, mix to get.
Preferably, the preparation method for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, it is wrapped
Include following steps：
Step A：Radix Astragali, Radix Glycyrrhizae and Sculellaria barbata are taken in parts by weight, and Radix Astragali, Radix Glycyrrhizae and three taste of Sculellaria barbata are ground into slightly
Powder, it is 50% ethyl alcohol that 8 times of amount volumetric concentrations, which are added, heating and refluxing extraction 3 times, 2 hours every time, filters and merge No. 3 extracting solutions,
It is concentrated into 2g crude drug/mL medical fluid A, it is spare；
Step B：The fruit of summer cypress and kuh-seng are taken in parts by weight, the fruit of summer cypress and kuh-seng are added water to cook 3 times, every time plus water volume
Amount is 10 times of medicinal material weight, 1.5 hours every time, filters and merges No. 3 extracting solutions, concentrate filtrate to the 1/ of original volume
3~1/4, it is cooled to room temperature, 95% ethyl alcohol of 3 times of volumes is added, agitates by adding, makes to mix well, stand 24 hours, filter out
Sediment by filtrate recycling ethanol and is concentrated into the thick shape medicinal extract that 55 DEG C of relative densities are 1.30~1.35, volumetric concentration is added
50% ethyl alcohol, heating dissolve medicinal extract, and dissolved solution is stood 24 hours, sediment is filtered out, obtains medical liquid B；
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water de-
To eluent be it is colourless, discard eluent, the ethanol elution for being then 20% with volumetric concentration to eluent is light color, discards and washes
De- liquid, then the ethanol elution for being 50% with volumetric concentration, collect eluent, eluent decompression, and recycling removes ethyl alcohol, is concentrated into 3g
Crude drug/mL medical fluid C；
Step D：Cortex cinnamomi, cloves are taken, the water that 10 times of volumes of medicinal material weight are added is obtained using extraction by steam distillation
To extractive of volatile oil；
Step E：The extractive of volatile oil that medical fluid C and step D are obtained mixes, and cow-bezoar is added, mix to get.
Preferably, the preparation method for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, it is special
Sign is：The alcohol of C1 described in step C~3 is methanol, ethyl alcohol or propyl alcohol.
Preferably, the preparation method for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, it is special
Sign is that the macroporous absorbent resin is D101, HPD100, AB-8 or X-5 macroporous absorbent resin.
Preferably, the preparation method for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, it is special
Sign is that pharmaceutically acceptable carrier is added in resulting Chinese medical extract, and Chinese materia medica preparation is made.
Preferably, the preparation method for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, it is special
Sign is that the Chinese materia medica preparation is the external preparation of liniment, ointment, gelling agent, spray or aerosol.
Preferably, above-described a kind of preparation side for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos
Method, resulting Chinese medical extract are added essence, are tuned into a certain concentration with second alcohol and water and are prepared into floral water.
The advantages of the present invention：
Radix Astragali energy supplementing Yuanyang in the traditional chinese medicine composition of the invention prescription is apt to mend ying, wei, qi, xue, fills space between skin and muscles, and wind dispelling fortune is malicious, Gu table
Anti- heresy is surgery man panacea.After bite by mosquitos, toxin invades skin surface, and human body can occur fierce confrontation, show as red
The reactions such as swollen, hot pain, itching, this is a kind of natural reaction of human body, is intended to for the foreign matters such as toxin being discharged except body.Radix Astragali can be bright
The aobvious this antagonism for reinforcing human body fleshy exterior helps quickly to remove toxin, has usually said " help " effect.Modern study
Show that Radix Astragali has the function of enhancing body specific immunity and nospecific immunity.
Cow-bezoar and Sculellaria barbata have effects that efficient heat-clearing, removing toxic substances, detumescence.Studies have shown that mosquito is stung in Sculellaria barbata external application
Wound has good detoxicating functions.
It is the fruit of summer cypress and kuh-seng heat-clearing, antipruritic.After bite by mosquitos, fierce confrontation, table can occur for toxin intrusion body surface human body
It is now the reactions such as red and swollen, hot pain, itching, itching reaction therein is extremely to make us not pleasant, especially children and infant
Skin can be scratched because of violent itching, and secondary germ infects.The combination of the fruit of summer cypress and kuh-seng is with splendid and what is be exceedingly fast stops
Itch effect.
Cortex cinnamomi and cloves are rich in volatile oil, and fragrance is walked to alter, and have the function of promoting the above Drug Percutaneous Absorption, make each medicine
Active component quickly enters skin histology, and the effect of fast onset respectively achievees the purpose that quickly " antipruritic, removing toxic substances, detumescence ".
Radix Glycyrrhizae has effects that making hundred poisoning of druies conciliates hundred poisoning of druies, and applying in Chinese medicine compound prescription can coordinating the drug actions of a prescription.Modern pharmacology
Research points out that the effective component of Radix Glycyrrhizae removing toxic substances is glycyrrhizin, and glycyrrhizin is known as cortex hormone of aadrenaline sample anti allergic reaction, can
It absorbs poisonous substance to absorb to reduce, improves body to the tolerance of toxicant.
To sum up, the traditional chinese medicine composition of the invention consolidates the anti-heresy of table with Radix Astragali, is monarch drug in a prescription；Cow-bezoar and Sculellaria barbata are clearing heat and detoxicating, summer cypress
Son and kuh-seng antipyretic and itching-stopping, are altogether ministerial drug；Cortex cinnamomi and cloves fragrance are walked to alter, and are altogether adjutant, Radix Glycyrrhizae tool hundred poisoning of druies of solution, as making
Medicine.The clearing heat and detoxicating, repellent antipruritic in full side, can be used for the quick repellent antipruritic of bite by mosquitos.
Invention is purified according to prescription medicinal material property using different extracting methods and using techniques such as macroreticular resins,
The content for improving effective component, the Chinese materia medica preparation and floral water being prepared are in the quick repellent antipruritic side for bite by mosquitos
Face significant effect has the advantages such as rapid-action, without side-effects, easy to use.Through animal experiment research shows that floral water of the present invention
Cavy itch-threshold can be significantly improved.Clinical application indicate that floral water of the present invention treats bite by mosquitos total effective rate 95%, put down
Itch caused by bite by mosquitos can be eliminated by smearing 5 minutes, and hot pain symptom can eliminate redness in 30 minutes.And documents
Chinese medicine composition is antipruritic for bite by mosquitos average 8 minutes, just reduces swelling in 1 day, therefore the traditional chinese medicine composition of the invention is reduced swelling and stopped
Effect of itching has significant progress compared with documents Chinese medicine composition.
Specific embodiment
The present invention is furture elucidated combined with specific embodiments below, it should be understood that these embodiments be merely to illustrate the present invention and
It is not used in and limits the scope of the invention, after the present invention has been read, those skilled in the art are to various shapes of equal value of the invention
The modification of formula falls within the application range as defined in the appended claims.
Embodiment 1
1, Chinese medicine composition of the present invention for relieving itching and eliminating swelling after bite by mosquitos
Prescription：50 parts of Radix Astragali, 6 parts of cow-bezoar, 40 parts of Sculellaria barbata, 50 parts of Radix Glycyrrhizae, 50 parts of the fruit of summer cypress, 40 parts of kuh-seng, cortex cinnamomi 50
Part, 50 parts of cloves.
2, the preparation step of Chinese traditional medicine composition composition liniment：
Step A：40 part of three 50 parts of Radix Astragali, 50 parts of Radix Glycyrrhizae and Sculellaria barbata taste are ground into coarse powder, add 50% second of volumetric concentration
Alcohol, heating and refluxing extraction 3 times, each ethyl alcohol volumetric usage is 8 times of medicinal material weight, 2 hours every time, filters and merges 3 times
It is spare to be concentrated into 1.5g crude drug/mL medical fluid A for extracting solution；
Step B：50 parts of the fruit of summer cypress and 40 parts of medicine materical crude slice of kuh-seng are added water to cook 3 times, every time plus water body accumulated amount is medicinal material weight
10 times of amounts, 1.5 hours every time, filter and merge No. 3 extracting solutions, concentrate filtrate to the 1/3~1/4 of original volume, cooling
To room temperature, 95% ethyl alcohol of 3 times of volumes is added, agitates by adding, makes to mix well, stands 24 hours, filter out sediment, will filter
Liquid recycling ethyl alcohol is simultaneously concentrated into relative density as 1.30~1.35 (55 DEG C) pastes, and the heating of 50% ethyl alcohol, which is added, keeps medicinal extract molten
Dissolved solution is stood 24 hours, filters out sediment, obtain medical liquid B by solution.
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water de-
It is light color to eluent, discards eluent, the ethanol elution for being then 20% with concentration to eluent is light color, discards elution
Liquid, then the ethanol elution for being 50 ethyl alcohol % with concentration, collect eluent, eluent decompression, and recycling removes ethyl alcohol, it is raw to be concentrated into 3g
Medicine/mL medical fluid C；
Step D：50 parts of cortex cinnamomi, 50 parts of cloves are taken, using 10 times of amount water extraction by steam distillation, obtains volatile oil extracting
Object.
Step E：The extractive of volatile oil that medical fluid C and step D are obtained mixes, and is added 6 parts of cow-bezoar, mixes, packing to get
Liniment of the present invention.
Embodiment 2
1, Chinese medicine composition of the present invention for relieving itching and eliminating swelling after bite by mosquitos
Prescription：30 parts of Radix Astragali, 1 part of In vitro cultured Calculus Bovis, 20 parts of Sculellaria barbata, 30 parts of Radix Glycyrrhizae, 30 parts of the fruit of summer cypress, kuh-seng 20
Part, 30 parts of cortex cinnamomi, 20 parts of cloves.
2, the preparation of the traditional chinese medicine composition of the invention ointment
Step A：20 part of three 30 parts of Radix Astragali, 30 parts of Radix Glycyrrhizae and Sculellaria barbata taste are ground into coarse powder, add 60% second of volumetric concentration
Alcohol heating and refluxing extraction 3 times, each ethanol consumption is 10 times of amounts, 1.5 hours every time, filters and merge No. 3 extracting solutions, is concentrated
It is spare to 3g crude drug/mL medical fluid A.
Step B：It by 30 parts and 2 parts of kuh-seng of the fruit of summer cypress, adds water to cook 3 times, each amount of water is 10 times of amount volumes, every time
1.5 hours, No. 3 extracting solutions are filtered and merged, the 1/3~1/4 of original volume is concentrated filtrate to, is cooled to room temperature, is added 3
95% ethyl alcohol of times volume, agitates by adding, makes to mix well, and stands 24 hours, filters out sediment, simultaneously by filtrate recycling ethanol
Being concentrated into relative density is 1.30~1.35 (55 DEG C) pastes, and the heating of 60% ethyl alcohol, which is added, dissolves medicinal extract, will be dissolved
Solution left standstill 24 hours, sediment is filtered out, medical liquid B is obtained；
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water de-
It is light color to eluent, discards eluent, it is light color that the ethyl alcohol alcohol for being then 20% with concentration, which is eluted to eluent, discards elution
Liquid, then the ethanol elution for being 50 ethyl alcohol % with concentration, collect eluent, eluent decompression, and recycling removes ethyl alcohol, it is raw to be concentrated into 3g
Medicine/mL medical fluid C；
Step D：30 parts of cortex cinnamomi, 20 parts of cloves are taken, using 8 times of amount water extraction by steam distillation, obtains volatile oil extracting
Object.
Step E：The extractive of volatile oil that medical fluid C and step D are obtained mixes, and is added 1 part of cow-bezoar, and ethyl hydroxy benzoate 1 is added
Part, 50 parts of lanolin and appropriate vaseline mix to get ointment of the present invention.
Embodiment 3
1, Chinese medicine composition of the present invention for relieving itching and eliminating swelling after bite by mosquitos
Prescription：80 parts of Radix Astragali, 10 parts of calculus bovis factitius, 60 parts of Sculellaria barbata, 60 parts of Radix Glycyrrhizae, 70 parts of the fruit of summer cypress, 60 parts of kuh-seng, meat
60 parts of osmanthus, 60 parts of cloves.
2, the preparation step of the traditional chinese medicine composition of the invention spray：
Step A：Radix Astragali, Radix Glycyrrhizae and three taste of Sculellaria barbata are ground into coarse powder, add 60% ethyl alcohol heating and refluxing extraction 3 times, often
Secondary ethanol consumption is 8 times of amounts, 2 hours every time, filters and merges No. 3 extracting solutions, be concentrated into 0.5g crude drug/mL medical fluid A.
Step B：The fruit of summer cypress and kuh-seng medicine materical crude slice are added water to cook 3 times, each amount of water be 10 times of amount volumes, 2 hours every time,
No. 3 extracting solutions are filtered and merged, the 1/3~1/4 of original volume is concentrated filtrate to, is cooled to room temperature, 3 times of volumes are added
95% ethyl alcohol, agitates by adding, and makes to mix well, and stands 24 hours, filters out sediment, by filtrate recycling ethanol and be concentrated into phase
It is 1.30~1.35 (55 DEG C) pastes to density, the heating of 50% ethyl alcohol, which is added, dissolves medicinal extract, and dissolved solution is stood
24 hours, sediment is filtered out, obtains medical liquid B.
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water de-
It is light color to eluent, discards eluent, it is light color that the ethyl alcohol alcohol for being then 30% with concentration, which is eluted to eluent, discards elution
Liquid, then be the ethanol elution of 60% ethyl alcohol with concentration, eluent, eluent decompression are collected, recycling removes ethyl alcohol, it is raw to be concentrated into 1g
Medicine/mL medical fluid C；
Step D：Cortex cinnamomi, cloves are taken, using 10 times of amount water extraction by steam distillation, obtains extractive of volatile oil.
Step E：The extractive of volatile oil that medical fluid C and step D are obtained mixes, and is added 10 parts of calculus bovis factitius, mixes, quantitative
It is divided in spray bottle, loads onto manual pump up to spray of the present invention.
Embodiment 4
The present invention-floral water preparation (one),
Prescription：50 parts of Radix Astragali, 6 parts of calculus bovis factitius, 40 parts of Sculellaria barbata, 50 parts of Radix Glycyrrhizae, 50 parts of the fruit of summer cypress, 40 parts of kuh-seng, meat
50 parts of osmanthus, 50 parts of cloves.
Preparation step：
Step A：40 part of three 50 parts of Radix Astragali, 50 parts of Radix Glycyrrhizae and Sculellaria barbata taste are ground into coarse powder, 30% ethyl alcohol is added to heat back
Stream extracts 3 times, and each ethanol consumption is 10 times of amounts, 2 hours every time, filters and merge No. 3 extracting solutions, and it is raw to be concentrated into 1.5g
Medicine/mL medical fluid A is spare.
Step B：It by 50 parts and 40 parts of kuh-seng medicine materical crude slice of the fruit of summer cypress, adds water to cook 3 times, each amount of water is 8 times of amount volumes, often
Secondary 2 hours, No. 3 extracting solutions are filtered and merged, the 1/3~1/4 of original volume is concentrated filtrate to, is cooled to room temperature, is added 3
90% ethyl alcohol of times volume, agitates by adding, makes to mix well, and stands 24 hours, filters out sediment, simultaneously by filtrate recycling ethanol
Being concentrated into relative density is 1.30~1.35 (55 DEG C) pastes, and the heating of 60% ethyl alcohol, which is added, dissolves medicinal extract, will be dissolved
Solution left standstill 24 hours, sediment is filtered out, medical liquid B is obtained.
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water de-
It is light color to eluent, discards eluent, it is light color that the ethyl alcohol alcohol for being then 40% with concentration, which is eluted to eluent, discards elution
Liquid, then the ethanol elution for being 80% with concentration, collect eluent, eluent decompression, and recycling removes ethyl alcohol, it is raw to be concentrated into 0.5g
Medicine/mL medical fluid C；
Step D：50 parts of cortex cinnamomi, 50 parts of cloves are taken, using 10 times of amount water extraction by steam distillation, obtains volatile oil extracting
Object.
Step E：The extractive of volatile oil that medical fluid C and step D are obtained mixes, and is added 6 parts of cow-bezoar, mixes, then flavoring essence,
Second alcohol and water adjusts concentration and is configured to required volumes of formulation to get floral water of the present invention.
Embodiment 5
The present invention-floral water preparation (two),
Prescription：80 parts of Radix Astragali, 10 parts of cow-bezoar, 60 parts of Sculellaria barbata, 60 parts of Radix Glycyrrhizae, 70 parts of the fruit of summer cypress, 60 parts of kuh-seng, cortex cinnamomi 60
Part, 60 parts of cloves.
Preparation step：
Step A：60 part of three 80 parts of Radix Astragali, 60 parts of Radix Glycyrrhizae and Sculellaria barbata taste are ground into coarse powder, 55% ethyl alcohol is added to heat back
Stream extract 2 times, each ethanol consumption be 8 times amount, 2 hours every time, filter and merge No. 2 extracting solutions, be concentrated into 1.0g crude drug/
ML medical fluid A is spare.
Step B：70 parts and 60 parts of kuh-seng medicine materical crude slice of the fruit of summer cypress are added water to cook 2 times, each amount of water is 8 times of amount volumes, often
Secondary 2 hours, No. 2 extracting solutions are filtered and merged, the 1/3~1/4 of original volume is concentrated filtrate to, is cooled to room temperature, is added 3
80% ethyl alcohol of times volume, agitates by adding, makes to mix well, and stands 24 hours, filters out sediment, simultaneously by filtrate recycling ethanol
Being concentrated into relative density is 1.30~1.35 (55 DEG C) pastes, and the heating of 60% ethyl alcohol, which is added, dissolves medicinal extract, will be dissolved
Solution left standstill 24 hours, sediment is filtered out, medical liquid B is obtained.
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water de-
It is light color to eluent, discards eluent, it is light color that the ethyl alcohol alcohol for being then 30% with concentration, which is eluted to eluent, discards elution
Liquid, then the ethanol elution for being 90% with concentration, collect eluent, eluent decompression, and recycling removes ethyl alcohol, it is raw to be concentrated into 1.0g
Medicine/mL medical fluid C；
Step D：60 parts of cortex cinnamomi, 60 parts of cloves are taken, using 8 times of amount water extraction by steam distillation, obtains volatile oil extracting
Object.
Step E：The extractive of volatile oil that medical fluid C and step D are obtained mixes, and is added 10 parts of cow-bezoar, mixes, then flavoring
Essence, second alcohol and water adjust concentration and are configured to required volumes of formulation to get floral water of the present invention.
Embodiment 6
The test of the traditional chinese medicine composition of the invention floral water antipruritic effect
1, test method：Reference《Study of tcm new drug guide》, bureau of drug policy & administration of the Ministry of Public Health, 2003.
2, test material：Cavy 30, half male and half female, 200-350 grams of weight.Histamine phosphate.Positive control：Certain commercially available product
Board antipruritus toilet water.Test sample：The resulting floral water finished product of the embodiment of the present invention 4.
3, experimental result
Floral water of the present invention is improved the effect of cavy itch-threshold, has compared with blank control group and positive controls significant
Sex differernce (P ﹤ 0.01 or P ﹤ 0.05).
The different groups of table 1 cause to itch the influence of reaction to histamine phosphate
Note：Compared with blank control group；△P ﹤ 0.01；Compared with positive controls；* P ﹤ 0.05
Embodiment 7
The traditional chinese medicine composition of the invention floral water treats mosquito bite observation of curative effect
1, object and grouping are observed：Subject 80.It is randomly divided into treatment group and control group.Treatment group 40, male 16,
Female 24；Age 1~55 years old.Control group 40, male 14, female 26；Age 1~60 years old.Two groups the age, gender, etc. side
Face no significant difference (P ﹥ 0.05), is comparable.
2, clinical symptoms：There is small red pimple in mosquito position of biting, red and swollen, bulge.Local itch unbearably, there is hot pain.
3, test material
(1) test sample：Floral water prepared by the embodiment of the present invention 4
(2) reference substance：The floral water that existing 201210315409.3 embodiment 6 of number of patent application is prepared
4, application method：Treatment group and control group are applied to using floral water of the present invention, certain brand antipruritus toilet water respectively
Mosquito bite position, 3~4 times.
5, criterion of therapeutical effect：It is effective：Clinical symptoms disappear within 30 minutes, and red dot redness disappears, local scratchiness and heat
Pain disappears；Effectively：Clinical symptoms disappear or substantially reduced substantially in 60 minutes, and red dot disappears substantially, and red and swollen bulge is obvious
It reduces, local scratchiness and heat pain are substantially reduced.In vain：Clinical symptoms do not improve within 4 hours, and red dot does not disappear, red
Swollen bulge is without improvement, and local scratchiness and heat pain are without improvement.
6, experimental result：
Test result shows the floral water treatment mosquito bite total effective rate 95% that the present invention is prepared, 5 minutes average
Itch disappears, red and swollen disappearance in 30 minutes.Control group floral water total effective rate is 77.5%, and two groups relatively have significant difference (P ﹤
0.05), above the experimental results showed that the present invention provide Chinese medicine composition prepared by floral water treatment due to mosquito bites red dot,
Red and swollen bulge and itch, heat pain have good curative effect, and effect is better than commercially available common floral water.Two groups of therapeutic effects, which compare, sees
Table 2：
2 two groups for the treatment of mosquito bite Clinical efficacy comparisons of table
Note：Compared with blank control group；*P ﹤ 0.05
7, safety evaluatio
(1) skin irritation test：Present composition floral water without skin irritation, also has no during the test
There are whole body or local adverse reaction.
(2) skin allergy test：Present composition floral water is to human skin substantially without sensitization.
8, curative effect explanation
The experimental results showed that, traditional Chinese medicine composition for treating group total effective rate provided by the invention is 95%, hence it is evident that is better than above
Control group, has many advantages, such as rapid-action, and relieving itching and eliminating swelling effect is good.
Typical case
1, permitted certain, female, 6 years old.Before this product is not used, after mosquito bite, the place of biting will appear redness, bulge, itch
Etc. symptoms, itch is hard to bear, is unable to bear scratching and grab, red and swollen bulge just can gradually subside after two days.Make within 10 minutes after mosquito bite
The liniment being prepared with the embodiment of the present invention 1, itch subside after 4 minutes, and red and swollen, bulge is subsided after ten minutes.It carries,
It is used for multiple times, antipruritic and detumescence is significant in efficacy.
2, Xue, male, 50 years old.Before this product is not used, after mosquito bite, the place of biting will appear redness, bulge, itch
Etc. symptoms, red and swollen area is larger, just can gradually subside after 3 days.It is prepared using the embodiment of the present invention 2 within 30 minutes after mosquito bite
Obtained ointment, itch subside after five minutes, and red and swollen, bulge is subsided after twenty minutes.By being used for multiple times, reduce swelling and antipruritic treatment
Effect is significant.
3, Lee, male, 10 years old.Before this product is not used, after mosquito bite, the place of biting will appear redness, bulge, itch
Etc. symptoms, red and swollen area is larger, just can gradually subside after 3 days.It is prepared using the embodiment of the present invention 5 within 20 minutes after mosquito bite
Obtained spray, itch subside after 4 minutes, and red and swollen, bulge is subsided after twenty minutes.By being used for multiple times, reduce swelling and antipruritic treatment
Effect is significant.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (11)
1. a kind of Chinese medicine composition for relieving itching and eliminating swelling after bite by mosquitos, which is characterized in that it by following parts by weight original
Expect that medicine is made：
30~80 parts of Radix Astragali, 1~10 part of cow-bezoar, 20~60 parts of Sculellaria barbata, 30~60 parts of Radix Glycyrrhizae, 30~70 parts of the fruit of summer cypress, kuh-seng
20~60 parts, 30~60 parts of cortex cinnamomi, 20~60 parts of cloves, wherein manually cow-bezoar or In vitro cultured Calculus Bovis replace cow-bezoar.
2. the Chinese medicine composition according to claim 1 for relieving itching and eliminating swelling after bite by mosquitos, which is characterized in that it is under
The bulk pharmaceutical chemicals of column parts by weight are made：
50 parts of Radix Astragali, 6 parts of cow-bezoar, 40 parts of Sculellaria barbata, 50 parts of Radix Glycyrrhizae, 50 parts of the fruit of summer cypress, 40 parts of kuh-seng, 50 parts of cortex cinnamomi, cloves 50
Part.
3. the Chinese medicine composition according to claim 1 for relieving itching and eliminating swelling after bite by mosquitos, which is characterized in that it is under
The bulk pharmaceutical chemicals of column parts by weight are made：
30 parts of Radix Astragali, 1 part of cow-bezoar, 20 parts of Sculellaria barbata, 30 parts of Radix Glycyrrhizae, 30 parts of the fruit of summer cypress, 20 parts of kuh-seng, 30 parts of cortex cinnamomi, cloves 20
Part.
4. the Chinese medicine composition according to claim 1 for relieving itching and eliminating swelling after bite by mosquitos, which is characterized in that it is under
The bulk pharmaceutical chemicals of column parts by weight are made：
80 parts of Radix Astragali, 10 parts of cow-bezoar, 60 parts of Sculellaria barbata, 60 parts of Radix Glycyrrhizae, 70 parts of the fruit of summer cypress, 60 parts of kuh-seng, 60 parts of cortex cinnamomi, cloves 60
Part.
5. the described in any item preparation methods for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos of Claims 1 to 4,
It is characterized in that, it includes the following steps：
Step A：Radix Astragali, Radix Glycyrrhizae and Sculellaria barbata are taken in parts by weight, and Radix Astragali, Radix Glycyrrhizae and three taste of Sculellaria barbata are ground into coarse powder, added
Enter 30%~80% ethyl alcohol of volumetric concentration, heating and refluxing extraction 1~3 time, each ethyl alcohol volumetric usage be medicinal material weight 4~
10 times of amounts, 1~3 hour every time, filter and merge No. 1~3 extracting solution, be concentrated into 0.25~5g crude drug/mL medical fluid A；
Step B：The fruit of summer cypress and kuh-seng are taken in parts by weight, the fruit of summer cypress and kuh-seng are added water to cook 1~3 time, every time plus water volume
Amount is 2~10 times of medicinal material weight, 1~3 hour every time, filters and merges No. 1~3 extracting solution, concentrate filtrate to original
The 1/3~1/2 of volume, is cooled to room temperature, and the 60%-95% ethyl alcohol of 1~3 times of volume is added, agitates by adding, and makes sufficiently mixed
It is even, 12~36 hours are stood, sediment is filtered out, by filtrate recycling ethanol and is concentrated into 50 DEG C of relative densities as 1.20~1.40
Thick shape medicinal extract adds 20%~60% ethyl alcohol, and heating dissolves medicinal extract, dissolved solution is stood 12~36 hours, filter
Except sediment, medical liquid B is obtained；
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water and take off to washing
De- liquid be it is colourless, discard eluent, it is light color that the alcohol of the C1 for being then 5~30% with concentration~3, which is eluted to eluent, discards elution
Liquid, then the alcohol of C1~3 for being 40%~95% with concentration elute, and collect eluent, eluent decompression, recycling removes the alcohol of C1~3, dense
It is reduced to 0.5~3g crude drug/mL medical fluid C；
Step D：Cortex cinnamomi, cloves are taken in parts by weight, the water of 8~15 times of volumes of medicinal material weight are added, using steam distillation
Method is extracted, and extractive of volatile oil is obtained；
Step E：The medical fluid C that step C is obtained and the extractive of volatile oil that step D is obtained are mixed, in parts by weight addition cow-bezoar,
Mix to get.
6. the described in any item preparation methods for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos of Claims 1 to 4,
It is characterized in that, it includes the following steps：
Step A：Radix Astragali, Radix Glycyrrhizae and Sculellaria barbata are taken in parts by weight, and Radix Astragali, Radix Glycyrrhizae and three taste of Sculellaria barbata are ground into coarse powder, added
Entering 8 times of amount volumetric concentrations is 50% ethyl alcohol, heating and refluxing extraction 3 times, 2 hours every time, filters and merge No. 3 extracting solutions, is concentrated
It is spare to 2g crude drug/mL medical fluid A；
Step B：The fruit of summer cypress and kuh-seng are taken in parts by weight, the fruit of summer cypress and kuh-seng are added water to cook 3 times, and every time plus water body accumulated amount is
10 times of medicinal material weight 1.5 hours every time, filter and merge No. 3 extracting solutions, concentrate filtrate to original volume 1/3~
1/4, it is cooled to room temperature, 95% ethyl alcohol of 3 times of volumes is added, agitates by adding, makes to mix well, stand 24 hours, it is heavy to filter out
Starch by filtrate recycling ethanol and is concentrated into the thick shape medicinal extract that 55 DEG C of relative densities are 1.30~1.35, volumetric concentration is added
50% ethyl alcohol, heating dissolve medicinal extract, and dissolved solution is stood 24 hours, sediment is filtered out, obtains medical liquid B；
Step C：Will medical fluid A and medical liquid B mix after upper large pore resin absorption column, after standing adsorption, be washed with deionized water and take off to washing
De- liquid be it is colourless, discard eluent, the ethanol elution for being then 20% with volumetric concentration to eluent is light color, discards elution
Liquid, then the ethanol elution for being 50% with volumetric concentration, collect eluent, eluent decompression, and recycling removes ethyl alcohol, it is raw to be concentrated into 3g
Medicine/mL medical fluid C；
Step D：Cortex cinnamomi, cloves are taken, the water that 10 times of volumes of medicinal material weight are added is waved using extraction by steam distillation
Hair oil extract；
Step E：The extractive of volatile oil that medical fluid C and step D are obtained mixes, and cow-bezoar is added, mix to get.
7. the preparation method according to claim 5 or 6 for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, special
Sign is：The alcohol of C1 described in step C~3 is methanol, ethyl alcohol or propyl alcohol.
8. the preparation method according to claim 5 or 6 for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, special
Sign is that the macroporous absorbent resin is D101, HPD100, AB-8 or X-5 macroporous absorbent resin.
9. the preparation method according to claim 5 or 6 for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, special
Sign is that pharmaceutically acceptable carrier is added in resulting Chinese medical extract, and Chinese materia medica preparation is made.
10. the preparation method according to claim 9 for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos, feature
It is, the Chinese materia medica preparation is the external preparation of liniment, ointment, gelling agent, spray or aerosol.
11. the preparation method according to claim 5 or 6 for the Chinese medicine composition of relieving itching and eliminating swelling after bite by mosquitos,
It is characterized in that, essence is added in resulting Chinese medical extract, is tuned into a certain concentration with second alcohol and water and is prepared into floral water.
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| CN106859962A (en) * | 2017-01-23 | 2017-06-20 | 安徽绿莹彩龙艾绒制药有限公司 | A kind of medicine moxa-moxibustion of moxibustion bite by mosquitos |
| CN109125163B (en) * | 2017-08-25 | 2022-07-22 | 伽蓝（集团）股份有限公司 | Glacier water composite extract of gentian, emblic leafflower fruit and artemisia integrifolia as well as preparation method and application thereof |
| CN111658714A (en) * | 2020-06-04 | 2020-09-15 | 青岛瑞思德生物科技有限公司 | Traditional Chinese medicine composition for relieving itching and diminishing swelling after mosquito bites |
| CN111588672A (en) * | 2020-06-30 | 2020-08-28 | 河北农业大学 | Edible itching-relieving emulsion for mosquito bites and preparation method thereof |
| CN114917161A (en) * | 2022-06-07 | 2022-08-19 | 栾云鹏 | Composition for relieving itching and pain after mosquito bites and preparation method and application thereof |
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| CN1056771C (en) * | 1996-12-09 | 2000-09-27 | 梅景升 | External application tincture named |
| CN1121231C (en) * | 2001-07-06 | 2003-09-17 | 徐章印 | Quick-acting mosquito-repellent antipruritic liquid and its preparing process |
| CN102247442B (en) * | 2011-06-13 | 2013-04-03 | 北京华夏众芳生物科技有限公司 | Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof |
| CN102784340B (en) * | 2012-08-09 | 2013-12-25 | 陈俊梅 | Traditional Chinese medicine composition for treating children eczema |
| CN103655718B (en) * | 2012-08-30 | 2015-02-18 | 北京妙心堂医药科技有限公司 | Traditional Chinese medicine composition, preparation, and floral water and application method thereof |
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