CN109464581A - A kind of composition and application thereof for alleviating Rhinitis Symptoms - Google Patents
A kind of composition and application thereof for alleviating Rhinitis Symptoms Download PDFInfo
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract
The invention discloses a kind of compositions for alleviating Rhinitis Symptoms, according to weight ratio meter, comprising: 8-15 parts of garlic extract;20-40 parts of lemon extract;1-5 parts of peppermint extracting solution;10-30 parts of distilled water.Composition provided by the invention one of at least has the advantage that 1. ingredient is simple, and main component garlic, lemon, peppermint are common food materials or medicinal material, and materials are convenient;2. preparation method is easy, user can be in self-control;3. directly being sucked by nasal cavity without using administrations such as oral or injections;4. alleviating Rhinitis Symptoms significant effect, without any adverse side effect;5. it is at low cost, it is suitble to large-scale promote.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, and in particular to a kind of composition and application thereof for alleviating Rhinitis Symptoms.
Background technique
Temperature cataclysm, nasal cavity have little time to adapt to the cataclysm of temperature, Yi Yinfa acute rhinitis;Undesirable living habit, often
Vibrissa is pulled out, picking the nose leads to nasal cavity skin injury and hair follicles damage and cause rhinitis;Inappropriate medication contains since collunarium waits drug quietly
There is nasal mucosa vessels contractile element, the slow poisoning reaction of schneiderian membrane can be caused;When work or living environment are in drying, powder
Dirt or noxious material pollution in the state of, such as vehicle exhaust, ornament materials and food additives etc., bronchia mucosal be stimulated and
Damage;Year, temperature rose year by year, and air-conditioning is popularized, and was the main reason for causing allergic rhinitis.
Rhinitis is a kind of relatively conventional illness, refers to schneiderian membrance or sub-mucosal tissues because of virus infection, germ infection, thorn
Swash object stimulation etc., schneiderian membrance or sub-mucosal tissues is caused to be damaged, caused acute or chronic inflammation usually causes runny nose, nose
Plug, patient with severe symptoms also generate the symptoms such as headache, dizziness, unsmooth breath, failure of memory.There are many drug of various treatment rhinitis,
But the effect is unsatisfactory for some drugs, or even also generates side effect, such as pharmacological dependence, nausea, hypogeusia etc. to body.
Doctor trained in Western medicine thinks that rhinitis is caused by virus infection, germ, and the treatment often taken is using antibiotic bactericidal antiphlogistic, hand
Art, laser etc., though can be quick, pain is big, palliative, and easy to recur and medical expense is high.
Chinese medicine thinks nose for key except lung, and lung opening at nose, lung qi then breathes plentifully tonneau, its pathogeny of rhinitis, nasosinusitis
At " lung ", mostly because of spleen and lung weakness, insufficiency of lung-QI,deficiency of lung-QI to weakened defensive QI, susceptible exopathogen.Spleen deficiency then be detained by transformation failure of spleen, phlegm wet, is stranded knot
Nose key, contamination sinus mucosa form nasosinusitis.Traditional Chinese medicine to treatment rhinitis curative effect it is reliable, toxic side effect is small, be fundamentally into
Row treatment.Traditional Chinese medicine for external application can be kept away by the potential toxicity of endo-medicine, and drug directly acts on nasal cavity, avoids laser,
Operation and plasma give nasal cavity bring wound, only need to smear medical fluid in nasal cavity, not take medicine, do not have an injection, drug action is obvious.
The Chinese medicine study report of many treatment rhinitis is disclosed at present, such as CN201110407550 discloses one kind and controls
Treat allergic rhinitis Chinese medicine composition, it is prepared from the following raw materials in parts by weight: 5~15 parts of Fermented Soybean, 1~5 part of peppermint,
1~5 part of asarum, 5~15 parts of zaocys dhumnade.CN201010264284 discloses a kind of for treating the Chinese traditional medicine composition of allergic rhinitis
Object, it is composed of the following components by weight: 5~28 parts of Flos Magnoliae Liliflorae, 5~25 parts of the root of Dahurain angelica, 4~27 parts of the achene of Siberian cocklebur, radix saposhnikoviae 3~26
Part, 10~25 parts of Radix Paeoniae Alba, 3~8 parts of ramulus cinnamomi, 5~20 parts of campanulaceae, 3~15 parts of Rhizoma Chuanxiong and 3~7 parts of calculus bovis factitius.These Chinese medicine systems
Agent to treatment rhinitis can play good action, but its complicated component, technically with there are still some shortcomings in cost.
Summary of the invention
Based on this, being in the purpose of the present invention is to provide a kind of user can be made by oneself, and alleviation rhinitis significant in efficacy
The composition of symptom.
The purpose of the present invention is what is be achieved through the following technical solutions:
First aspect present invention provides a kind of composition for alleviating Rhinitis Symptoms, according to weight ratio meter, comprising: garlic is extracted
8-15 parts of liquid;20-40 parts of lemon extract;1-5 parts of peppermint extracting solution;10-30 parts of distilled water.
Garlic (scientific name: Garlic) is called garlic, garlic, giant garlic, calabash, only garlic, single clove garlic, is the system of garlic class plant
Claim.Semi-annual herbaceous plant, Liliaceae allium, is used as medicine with bulb.Nature and flavor: temperature, it is pungent, sweet.Function: middle benefit gas stomach invigorating, help digestion qi-regulating.
Garlic has all multiactions such as anti-inflammatory, sterilization, health care, and since it is a kind of food materials, will not generate drug
Any side effect can be used as the desirable material for eliminating rhinitis germ.But garlic taste is strong and has irritation, Huan Zheyi
As can not endure the irritation and abandon medication.
Lemon (scientific name: Citrus limon (L.) Burm.f.), Rutaceae citrus plant, lemon are also known as lemon fruit, foreign lemon
Female fruit of lemon, benefit etc..Because of the special acid of taste, therefore it can only be used as first-class seasoning, be used to modulation beverage dish, cosmetics and drug.
In addition, lemon is rich in vitamin C, energy preventing phlegm from forming and stopping coughing, stomach invigorating of promoting the production of body fluid.For bronchitis, pertussis, loss of appetite, vitamin
Lack, the symptoms such as heatstroke polydipsia, it is the jinx of " scurvy ".
Together peppermint, the Classification system popular name (Menthahaplocalyx Briq.) are Lamiaceae plant, i.e., " lunar caustic grass "
Belong to other drying herbs.Peppermint is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, control influenza, headache,
The diseases such as hot eyes, body heat, throat, gum swelling and pain.External application can control neuralgia, pruitus, fash and eczema etc..
Garlic extract described herein, lemon extract, peppermint extracting solution are respectively by garlic, lemon, peppermint
It squeezes the juice, as obtained by being centrifuged and/or filter.
Distilled water in the application can be replaced drainage is crossed obtained by Drinking Water Filtration.
In the specific embodiment of the present invention, according to weight ratio meter, the composition includes garlic extract 10-
12 parts;25-34 parts of lemon extract;2-4 parts of peppermint extracting solution;15-24 parts of distilled water.
In the specific embodiment of the present invention, according to weight ratio meter, the composition includes garlic extract 10
Part;30 parts of lemon extract;2 parts of peppermint extracting solution;20 parts of distilled water.
In the specific embodiment of the present invention, according to weight ratio meter, the garlic extract, lemon extract,
Peppermint extracting solution, the ratio of distilled water are 10:20-40:1-5:10-30, it is preferable that the garlic extract, lemon extract,
Peppermint extracting solution, the ratio of distilled water are 10:25-35:2-4:15-25.
In the specific embodiment of the present invention, according to weight ratio meter, the garlic extract, lemon extract,
Peppermint extracting solution, the ratio of distilled water are 10:30:2:20.
In the specific embodiment of the present invention, according to weight ratio meter, the composition is extracted by 8-15 portions of garlics
Liquid, 20-40 parts of lemon extracts, 1-5 parts of peppermint extracting solutions and 10-30 parts of distilled water compositions.
In the specific embodiment of the present invention, according to weight ratio meter, the composition is extracted by 10-12 portions of garlics
Liquid, 25-34 parts of lemon extracts, 2-4 parts of peppermint extracting solutions and 15-24 parts of distilled water compositions.
In the specific embodiment of the present invention, according to weight ratio meter, the composition by 10 parts of garlic extract,
30 parts of lemon extract, 2 parts of peppermint extracting solution, 20 parts of distilled water compositions.
In the specific embodiment of the present invention, according to weight ratio meter, the composition is extracted by 8-15 portions of garlics
Liquid, 20-40 parts of lemon extracts, 1-5 parts of peppermint extracting solutions and 10-30 parts of distilled water compositions, wherein the garlic extract,
Lemon extract, peppermint extracting solution, the ratio of distilled water are 10:20-40:1-5:10-30.Preferably, the garlic extract,
Lemon extract, peppermint extracting solution, the ratio of distilled water are 10:25-35:2-4:15-25.It is highly preferred that the garlic is extracted
Liquid, lemon extract, peppermint extracting solution, the ratio of distilled water are 10:30:2:20.
The preparation method of another aspect of the present invention offer above-mentioned composition comprising: garlic, lemon, peppermint are squeezed
The juice squeezed is filtered or is centrifuged to extract supernatant by juice.
Another aspect of the present invention provides purposes of the above-mentioned composition in the drug that Rhinitis Symptoms are alleviated in preparation.
In the specific embodiment of the present invention, the rhinitis is chronic and allergic rhinitis.
Chronic and allergic rhinitis, Chinese medicine are known as " allergic rhinitis ", are to be accumulate product by wind, wet, pyreticosis are evil and caused in nose key.
In the specific embodiment of the present invention, the drug be alleviate rhinitis caused by nasal obstruction, rhiocnesmus, more tears,
Smell decline, headache, dizzy drug.
In the specific embodiment of the present invention, the drug is administered in such a way that nasal cavity sucks.
The present invention one of at least has the advantage that:
The present invention provides a kind of composition, and 1. ingredient is simple for the composition, and main component garlic, lemon, peppermint are
Common food materials or medicinal material, materials are convenient;2. preparation method is easy, user can be in self-control;3. without using oral or note
It the administration such as penetrates, directly passes through nasal cavity sucking;4. alleviating Rhinitis Symptoms significant effect, without any adverse side effect;5. cost
It is low, it is suitble to large-scale promote.
Detailed description of the invention
Fig. 1 show the experimental result that composition provided in an embodiment of the present invention tests nasal cavity itch patient's using effect
Figure.
Fig. 2 show the experiment that composition provided in an embodiment of the present invention tests the unsmooth patient's using effect of nose breathing
Result figure.
Fig. 3 show composition provided in an embodiment of the present invention to the experimental result picture of sneezing test.
Fig. 4 show composition provided in an embodiment of the present invention to the experimental result picture for test of having a running nose.
Fig. 5 show composition provided in an embodiment of the present invention to the experimental result picture of throat impression test.
Specific embodiment
Unless otherwise defined, all technical and scientific terms used in the present invention have and technical field of the present invention
The normally understood identical meanings of those of ordinary skill.
Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear that institute
The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, originally
Field those of ordinary skill every other embodiment obtained without creative efforts, belongs to the present invention
The range of protection.
The selection of example 1 group polymer component
The application, which is intended to explore, inhibits using pure natural, common edible plants extracting solution or alleviates Rhinitis Symptoms.
Wherein based on garlic extract, select orange, lemon, peppermint extracting solution and its mix and tested, with configure can use
In the composition for alleviating Rhinitis Symptoms.Operating process is as follows:
1. choosing fresh garlic, orange, lemon, peppermint, it is crushed respectively, is squeezed the juice.
2. by the juicing prefiltration in step 1, such as removed garlic is miscellaneous using gauze, collects filtered fluid.
3. above-mentioned filtered fluid is centrifuged, 8000rpm, it is centrifuged 10min, takes supernatant spare.
4. testing garlic, orange, lemon, combination and proportion between peppermint.
Specific experiment step:
It chooses lemon, orange, peppermint and garlic and carries out proportion prediction, by hearing taste, smell is adjusted, Stepwise Screening proportion
In, the irritation taste of garlic on the one hand can be eliminated, its function and effect to patients with rhinitis is on the other hand tested.It screened
Journey, 5 parallel repetitions are at least arranged in each proportion, to guarantee the reliability of experimental result.
1. testing the proportion between garlic and orange
Garlic is tested from orange according to different proportions, specific experiment processes result is as shown in table 1.
Proportioning test between 1 garlic of table and orange
Ratio/title | Garlic | Orange | Distilled water | Taste removal effect |
1:2 | 1 | 2 | 0 | It is garlicky very big |
1:3 | 1 | 3 | 0 | It is garlicky very big |
1:2:1 | 1 | 2 | 1 | It is garlicky very big |
1:3:2 | 1 | 3 | 2 | Still have garlicky |
1:2:2 | 1 | 2 | 2 | Still have garlicky |
1:3:1 | 1 | 3 | 1 | Still have garlicky |
By above-mentioned table 1 it is found that orange is less desirable for the taste removal effect of garlic.
2. testing the proportion between garlic and lemon
Garlic is tested from lemon according to different proportions, specific experiment process and the results are shown in Table 2.
Proportioning test between 2 garlic of table and lemon
Ratio/title | Garlic | Lemon | Distilled water | Taste removal effect |
1:2 | 1 | 2 | 0 | Still have garlicky |
1:3 | 1 | 3 | 0 | Still have garlicky |
1:2:1 | 1 | 2 | 1 | Garlicky reduction |
1:3:2 | 1 | 3 | 2 | Garlicky reduction |
1:2:2 | 1 | 2 | 2 | There is improvement |
1:3:1 | 1 | 3 | 1 | There is improvement |
By above-mentioned table 2 it is found that lemon can improve the taste of garlic.
3. testing the proportion between garlic and peppermint
Garlic is tested from peppermint according to different proportions, specific experiment process and the results are shown in Table 3.
As shown in Table 3, peppermint can also improve the taste of garlic.
Present inventor test garlic and orange, lemon, peppermint proportion during find, removing garlic
In irritation taste tests, distilled water also plays crucial effect, compared with distilled water is not added, distilled water is added, then garlic
Irritating taste can significantly reduce.
By above-mentioned experiment, orange is eliminated, using lemon, peppermint, distilled water and garlic as the raw material of composition.
The preparation of 2 composition of embodiment
Using garlic, lemon, peppermint and distilled water as component, composition is prepared.According to weight ratio meter, each composition it is specific
Ingredient and content such as the following table 4:
The specific ingredient and content of each composition of table 4
Example | Garlic (part) | Lemon | Peppermint | Distilled water | Taste removal effect |
1 | 8 | 40 | 1 | 10 | Complete taste removal |
2 | 15 | 20 | 5 | 30 | Complete taste removal, slightly fragrance |
3 | 12 | 34 | 4 | 24 | Basic taste removal |
4 | 10 | 25 | 3 | 14 | Basic taste removal |
5 | 10 | 30 | 2 | 20 | Complete taste removal, it is savory |
Each composition of offer in above 5 examples, irritating taste of garlic are substantially all and can remove.It will be upper
The composition provided in 5 examples is provided, is supplied to patients with rhinitis in use, patient can receive its taste, and to patient
Rhinitis situation all there is certain curative effect.Wherein, especially the most obvious with the therapeutic effect in example 5.In order to further really
Determine the ratio between garlic, lemon, peppermint and distilled water, inventor tests the proportion between them based on example 5
Influence to treatment patient's rhinitis.
3 garlic of embodiment, lemon, peppermint different proportion proportion
Garlic, lemon, peppermint are tested according to different proportion proportion, based on 10 parts of garlic, adjustment lemon, thin
The ratio of lotus and distilled water and garlic, specific experiment process and the results are shown in Table 5.
Proportioning test between 5 garlic of table and lemon, peppermint
As shown in Table 5, when garlic and lemon, peppermint and distilled water mix, it is irritating garlic can be eliminated
Taste or even the fragrance of some lemons or peppermint.Above-mentioned experimental result proves distilled water to the irritation for eliminating garlic again
Taste plays an important role.According to above-mentioned experimental result, selects the composition in serial number A, B, C, D and proportion to carry out rhinitis and control
Treat test.
Treatment of 4 subject composition of embodiment to rhinitis
The composition chosen in serial number A, B, C and D gives heavier, slight, the seasonal breaking-out of rhinitis in household and friend respectively
12 patients use, the use of the time is 1 month (PLSCONFM), and records impression and effect after patient's use.
Use step: in use, the left nose hole of participant is pinned, and nostril spray clear water of turning right, every one minute nostril of turning right
Spray composition.The right nostril of participant is pinned, and sprays clear water in nostril of turning left, sprayed composition in nostril of turning left every one minute.Sense
By control curative effect, the results are shown in Table 6 for experiment.
Treatment condition of table 6A, B, C, D different ratio to 12 patients
As can be seen from Table 6, above-mentioned composition is particularly evident compared with the therapeutic effect of severe one to rhinitis, controls compared with less serious case
Therapeutic effect needs just show for a long time;Composition has significant suppression to mitigating rhinostegnosis, uncomfortable in chest, abundant expectoration, dizzy brain and rise etc.
Effect processed.Smell by the composition that it is in B, to patients with rhinitis can be restored, it is seen then that garlic, lemon, peppermint and distillation
The optimal proportion of water is 10:30:2:20.
The application of 5 composition of embodiment alleviation Rhinitis Symptoms
The patient with rhinitis and volunteer 50 are chosen, using the composition of serial number B in embodiment 4, according to: it pins
One nostril of participant sprays clear water toward his/her another nostril, sprayed the mode of composition again every one minute, carry out to according to the facts
It tests, and fills in record sheet, it is each primary daily morning and evening, one month by a definite date.
The record sheet being collected into is for statistical analysis according to the different symptoms of rhinitis, experimental result such as Fig. 1-Fig. 5.
Fig. 1 is the test result figure that the composition of serial number B tests nasal cavity itch.From fig. 1, it can be seen that suffering from the 50 of rhinitis
In people, wherein 46 people's nasal cavities no longer itch, other 4 people, although nasal cavity itch does not improve completely, symptom obviously subtracts
Gently.
Test result figure of the composition to nose breathing blocking test that Fig. 2 is serial number B.As can be seen from Figure 2, rhinitis is suffered from
50 people in, wherein 44 people's nasal cavities are unimpeded, can normally breathe with the nose, by its be at night, never again because unsmooth breath and
Influence sleep quality;Other 6 people, although symptom is substantially reduced without improving completely.
Test result figure of the composition that Fig. 3 is serial number B to sneezing patient's test.As can be seen from Figure 3, with rhinitis
In 50 people, wherein 22 people are without sneezing symptom, other suffer from 28 people of sneezing symptom, are alleviated, sneezing
Number significantly reduces, or even sneezing is caused due to rhinitis.
Fig. 4 is the test result figure that the composition of serial number B tests rhinorrhea patient.As can be seen from Figure 4, with rhinitis
In 50 people, wherein 45 people stop having a running nose, other patients continue to have a running nose or without nasal mucus.
Test result figure of the composition that Fig. 5 is serial number B to the throat impression test of patients with rhinitis.As can be seen from Figure 5, suffer from
Have in 50 people of rhinitis, wherein 12 people do not have the symptom of throat pain, other 38 people have the symptom of throat pain.Use sequence
After number for the composition of B, in 38 patients with throat pain, 34 patient's throats are clearly better, or even no longer pain,
Only 4 people's effects are less obvious.
The comparison of the composition of 6 the application of embodiment and existing drug therapy patients with rhinitis
Treatment method: the composition of the example 1-5 in embodiment 2 is respectively adopted as therapeutic agent, every time into nasal cavity
Spray 100mg, each primary daily morning and evening.Using the therapeutic agent as a control group of compound furacilin nasal drops in the market, with 7 days for one
Secondary, 4 times as a treatment course, treats 2 courses for the treatment of respectively.
Treatment object: 300 outpatient service patients with rhinitis, wherein male 192, women 108, age distribution was at 18-60 years old
Between, the course of disease was at 6 months~20 years.300 patients are randomly divided into six groups, every group of 50 people.
Diagnostic symptom is main are as follows: intermittence is alternately had a stuffy nose, hyposphresia, more with symptoms such as headache, giddies
Tears are often mucus or glutinous purulence, and majority are easily tired, easily hair flu, failure of memory, nasal decongestion, concha hypertrophy etc..
Treatment standard: recovery from illness, symptom all disappear, and nasal cavity checks normal;Effectively, nasal obstruction, runny nose symptom mitigate, local volume
Sign improves.
Treatment results: as shown in table 7.
7 comparative test of table
Project | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Control |
Patient populations | 50 | 50 | 50 | 50 | 50 | 50 |
Recovery from illness number | 44 | 45 | 44 | 46 | 47 | 26 |
Cure rate | 88% | 90% | 88% | 92% | 94% | 52% |
Efficiently individual quantity | 49 | 49 | 50 | 49 | 50 | 37 |
It is efficient | 98% | 98% | 100% | 98% | 100% | 74% |
As can be seen from Table 7, the therapeutic effect of composition provided by the present application is much better than compound furacilin nasal drops.
In conclusion the composition provided in the embodiment of the present application can improve the symptom of patients with rhinitis, to reduction
Nasal mucus, alleviation nasal cavity itch, alleviation rhinostegnosis, reduction sneeze etc. all have good curative effect, in patient's throat pain
Aspect also has significant curative effect.And the raw material of the composition in the application derives from the food materials in daily life, no
It is only from a wealth of sources, without any side effect, and according to preparation method provided herein, using juice extractor, gauze and
Water filter membrane etc. can be prepared, easy to operate, be suitable for any family.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, made any modification, equivalent replacement etc. be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of composition for alleviating Rhinitis Symptoms, which is characterized in that according to weight ratio meter, comprising:
8-15 parts of garlic extract;20-40 parts of lemon extract;1-5 parts of peppermint extracting solution;10-30 parts of distilled water.
2. composition as described in claim 1, which is characterized in that according to weight ratio meter, including 10-12 parts of garlic extract;
25-34 parts of lemon extract;2-4 parts of peppermint extracting solution;15-24 parts of distilled water.
3. composition as claimed in claim 2, which is characterized in that according to weight ratio meter, including 10 parts of garlic extract;Lemon
30 parts of extracting solution;2 parts of peppermint extracting solution;20 parts of distilled water.
4. composition as described in claim 1, which is characterized in that according to weight ratio meter, the garlic extract, lemon is extracted
Liquid, peppermint extracting solution, the ratio of distilled water are 10:20-40:1-5:10-30.
5. composition as claimed in claim 4, which is characterized in that according to weight ratio meter, the garlic extract, lemon is extracted
Liquid, peppermint extracting solution, the ratio of distilled water are 10:30:2:20.
6. composition as described in claim 1, which is characterized in that according to weight ratio meter, the composition is by 8-15 portions of garlics
Extracting solution, 20-40 parts of lemon extracts, 1-5 parts of peppermint extracting solutions and 10-30 parts of distilled water compositions.
7. composition as described in claim 1, which is characterized in that according to weight ratio meter, the composition is by 10-12 portions of garlics
Extracting solution, 25-34 parts of lemon extracts, 2-4 parts of peppermint extracting solutions and 15-24 parts of distilled water compositions.
8. composition as described in claim 6, which is characterized in that according to weight ratio meter, the garlic extract, lemon is mentioned
Liquid, peppermint extracting solution are taken, the ratio of distilled water is 10:20-40:1-5:10-30.
9. purposes of the composition of any of claims 1-8 in the drug that Rhinitis Symptoms are alleviated in preparation.
10. purposes as claimed in claim 9, which is characterized in that the drug is nasal obstruction caused by alleviating rhinitis, rhiocnesmus, more
Tears, smell decline, headache, dizzy drug.
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CN201910047179.9A CN109464581A (en) | 2019-01-18 | 2019-01-18 | A kind of composition and application thereof for alleviating Rhinitis Symptoms |
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CN108014175A (en) * | 2017-11-30 | 2018-05-11 | 陈炳坤(天津)生物技术有限公司 | A kind of plant composition for being used to alleviate Rhinitis Symptoms |
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US20230190681A1 (en) * | 2021-12-16 | 2023-06-22 | Hector Gonzales | Topical Ointment Composition, Methods Of Use, And Methods Of Preparation |
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