WO2021251617A1

WO2021251617A1 - Crude drug composition for alleviating or treating rhinitis, pharmacopuncture solution of oriental medicine comprising same, injection comprising same, and pharmacopuncturing method using same

Info

Publication number: WO2021251617A1
Application number: PCT/KR2021/005102
Authority: WO
Inventors: 김성기
Original assignee: (주)오성내츄럴바이오; 김성기
Priority date: 2020-06-12
Filing date: 2021-04-22
Publication date: 2021-12-16
Also published as: KR102209883B1

Abstract

The present invention relates to a composition for alleviating and/or treating rhinitis and, more particularly, to a crude drug composition for alleviating and/or treating rhinitis consisting of natural herbal ingredients using a complex of several herbal ingredients, which may be provided in the form of a pharmacopuncture solution or injection of herbal medicine.

Description

Herbal composition for alleviating or treating rhinitis, herbal medicine containing same, injection containing same, and medicinal acupuncture method using same

The present invention relates to a herbal composition for alleviating or treating rhinitis using a complex herbal ingredient, and unlike the conventionally consumed rhinitis treatment, it is applied to acupuncture, an oriental medicine, and used as a medicinal acupuncture component of acupuncture, or by direct injection by injection. It relates to a novel herbal composition capable of alleviating rhinitis and/or innovative treatment.

Symptoms such as a clear runny nose, stuffy nose, and sneezing are called rhinitis or allergic rhinitis. In recent years, the number of rhinitis patients is increasing exponentially around the world, and Korea is no exception. In Korea, 4 out of 10 people suffer from rhinitis, and according to health information data in 2018, approximately 7 million people in Korea received hospital treatment. Rhinitis is a chronic disease that can not be treated well with both Western medicines and oriental medicine.

If you look at the known causes of rhinitis, the most common cause is allergy. Symptoms due to allergy are so common that 15% of Koreans suffer from it, and it is known that they are inherited from their children. If one parent is allergic, there is a 50% chance that the child will develop an allergy, and if both parents are allergic, the chance is 75%. If the allergen is tested and identified, drug treatment or immunotherapy can be performed.

Among non-allergic rhinitis, infectious rhinitis exists. This is a common cold, but it is said that the common cold is caused by a virus. Inside the nose, there is a space called the nasal cavity, which is caused by the virus inflaming the mucous membrane of the nasal passages. Infectious rhinitis is common enough that most people experience 1 or 2 times a year, but if it does not heal properly and persists for more than a month, it is called chronic infectious rhinitis. Should be.

Other causes of rhinitis include drug rhinitis. A topical nasal mucosal constrictor, known as a spray for nasal congestion, is a drug used when the nasal mucosa is swollen and blocked. It is a rhinitis that occurs as the blockage becomes more severe.

The treatment method is different depending on the cause of rhinitis, but the fundamental management method is similar. The best way to increase immunity is to increase resistance to the cause of rhinitis. Separately, rhinitis is treated and managed with the help of western or oriental treatment.

On the other hand, unlike generally known, the biggest cause of rhinitis is in the lungs, not the nose. The problem with rhinitis is a decrease in the local immunity of the lungs, not the overall immunity of the body. In other words, rhinitis is a local disease in which symptoms appear in the nose when the lungs become cold when the immunity of the lungs is weakened and the vaporization power is insufficient. This can be seen well by looking at the situation in which rhinitis is intensifying, and when you drink cold air, clear runny nose comes out more and you can see that the symptoms of rhinitis worsen.

To be more specific, when a human breathes, water is expelled along with air from the lungs in the body when exhaling. At this time, in people with normal lung immunity, 100% of the moisture in the lungs is vaporized and blown out of the body upon exhalation. The water that could not escape in this way starts to accumulate in the nasal passages or sinuses in the nose, and when the amount increases, it becomes water droplets and clear runny nose flows out of the nose. A kind of condensation-like phenomenon occurs in the nose.

On the other hand, if rhinitis is not treated in a timely manner, unvaporized moisture accumulates in the nasal sinuses, creating a favorable environment for bacteria to live. As a result, bacteria invade and a yellow runny nose flows, which is called sinusitis. In this case, you will experience both pains of rhinitis and sinusitis, and treatment is difficult and time-consuming because rhinitis and sinusitis must be treated together. If you treat only the symptoms that occur, it will only be good for a while at the time of treatment, and you will not be able to fundamentally cure the disease.

As described above, rhinitis occurs when the immunity of the lungs is low, so it is important to know the cause of the decrease in the immunity of the lungs. The cause of the weakening of the immune system in the lungs is

First, because of the constitution, if the immune system of the lungs is low from birth, and a person born unable to adapt to the cold environment changes, the symptoms of rhinitis are more likely to be expressed than in a normal person.

Second, there is the development of air conditioning (air conditioning) culture. As the time spent inhaling the cold air conditioner in the room increases, the internal temperature of the lungs, which plays a crucial role in the immunity of the lungs, gradually decreases. In particular, if the symptoms of rhinitis are fixed, drinking cold or polluted air will act as a catalyst to make the symptoms worse.

While the present inventor was researching the field of application of natural herbal ingredients for rhinitis, he found out about the key cause of rhinitis and the optimal composition of natural herbal ingredients effective for alleviation and/or treatment of rhinitis, and found an effective method for applying it to the treatment of rhinitis. was completed. That is, the present invention is to provide a pharmaceutical composition for alleviating and treating rhinitis using a herbal complex extract, and an invention using the same.

In order to achieve the above object, the present invention is an effective extract obtained by distilling an extract obtained by extracting a herbal complex including ginseng, leaflet, hyeonggae, ephedra, haengin, jawan, sesin, poison ivy, windbreak, persimmon licorice as an extraction solvent. A first step of proposing a herbal composition for rhinitis alleviation or treatment comprising as an ingredient, and preparing a herbal complex including ginseng, lobules, hyeonggae, ephedra, passersby, jawan, sesin, poison ivy, windbreak, and licorice; a second step of preparing a mixed solution by adding the herbal complex to an extraction solvent and then stirring; Step 3 of heating the mixed solution to obtain a concentrated extract by distilling the mixed solution; We propose a method for preparing a herbal composition for alleviating or treating rhinitis, comprising performing a process comprising: filtering the concentrated extract to obtain the essence, and for alleviating or treating rhinitis obtained through such a composition and manufacturing method We propose an acupuncture method in which acupuncture is performed on white tiger blood and pulmonary blood transfusion, which is acupuncture points, with herbal acupuncture containing herbal composition, and injection solution containing herbal composition for alleviating or treating rhinitis.

The herbal composition for alleviating or treating rhinitis of the present invention is an herbal acupuncture solution for oriental herbal medicine or injection, unlike the existing rhinitis treatment agents that are absorbed and absorbed into the digestive tract by drinking. Side effects and tolerance do not occur at all, and the rhinitis improvement effect is quickly generated.

The herbal composition for alleviating or treating rhinitis of the present invention (hereinafter, referred to as "the present invention composition") comprises: 1 step of preparing a herbal complex; a second step of preparing a mixed solution after adding the herbal compound to an extraction solvent; Step 3 of heating and distilling the mixed solution to obtain a concentrated extract; and 4 steps of filtering the extract to obtain the essence; it can be prepared by performing a process comprising a.

First, the herbal compound in the first stage will be described.

The herbal complex includes ginseng, leaflet, hyeonggae, ephedra, passerby, jawan, sesin, poisonous, windbreak, and licorice.

Ginseng is the root of Panax ginseng C. A. Meyer of the Araliaceae family, with the fine root and cork layer removed. There are white ginseng (raw), red ginseng (steamed), and fine ginseng (fine root). In the present invention, dried white ginseng is used.

Leaflets are medicinal herbs made from the leaves of Perilla frutescens var. acuta KUDO., an annual herb belonging to the Lamiaceae family. The seeds are called soya, and they are widely cultivated in various places. The active ingredient contains about 0.5% of essential oil, among which perylaldehyde 55%, cumic acid, perill alcohol, and the like are contained. The taste is bitter and slightly bitter, and the weakness is warm. The medicinal effect is used for the symptoms of cough and rhinitis, which do not cause sweating due to a cold, and are sometimes accompanied by chills and fever. In particular, it is an essential drug for the symptoms of a cold with digestive disorders. In addition, it is comfortable while discharging gas to the outside when complaining of bloating due to a food disorder and poor digestion. It is a vomitus egg, which occurs a lot in summer, and is highly effective for symptoms of twisted limbs and frequent vomiting, and is used for indigestion caused by eating cold food or a full stomach. In addition, it is widely used for the symptoms of being hungry during pregnancy, breathing hard, and not being able to lie down well.

Other names for Hyeonggae are Gaso, Sign, and Kanggae. Hungae Schizonepeta tenuifolia Briq, a plant from the family Lamiaceae. Or dried out plants of Nepeta japonica Maxim. planted everywhere. When the flowers bloom in the summer, cut the outpost and dry it in the shade with good ventilation. The taste is spicy and bitter, and the nature is warm. Acts on menopause and liver cirrhosis. It causes sweating, removes wind and cold, and removes blood clots. The charred will stop the bleeding. In pharmacological experiments, it was found that the decoction exhibits a weak antipyretic action, an action to promote sweat secretion, an action to speed up blood circulation in the skin, an antispasmodic action, a digestive action, and an antibacterial action.

Ephedra is the dried outpost of the ephedra family plants, Pulma Hwang [Cho Ephedra] Ephedra sinica Stapf., Horsetail Ephedra [Purpose Ephedra] Ephedra equisetina Bge. In the fall, cut unwooden outposts and dry them in the shade. The taste is spicy and bitter, and the nature is warm. It acts on menopause, cystoscopy, heart and colon. It causes sweating, soothes rhinitis, and promotes urination. The component ephedrine relaxes bronchial smooth muscle, increases blood pressure, and induces sweating. In addition, it promotes gastric juice and salivation, and also acts as mydriatic.

The passer-by is from the Prunus apricot tree Prunus armeniaca var. Dried seeds of ansu Maxim. and wild apricot P. mandshurica Koehne. Apricots and wild apricots grow in the mountains and fields of various parts of our country. Pick ripe fruits, peel them, peel off the hard skins, and soak them in boiling water to remove the seed skins. The taste is bitter and sweet, and the nature is warm. Acts on menopause and colonoscopy. It stops coughing, soothes rhinitis, makes feces come out well, sweats, and detoxifies. It has been found in experiments that the component amygdalin exhibits an anti-inflammatory action.

Jawan is the dried root of Aster tataricus L. fil., a plant in the Asteraceae family. It grows widely in the mountains of various places. In autumn, dig up the roots, cut off the stems, wash them in water and dry them in the sun. The taste is bitter and bitter, and the nature is warm. Acts on menopause It removes phlegm, stops coughing, and promotes good urine output. In pharmacological experiments, expectorant action, antipyretic action, anticancer action, and antibacterial action were found. The expectorant action is shown by the saponin component, and the diuretic action by the quercetin component. It is used for coughing and shortness of breath with sputum, and for inability to urinate. It can also be used for acute bronchitis and lung abscesses.

Sesin is a medicinal herb that has been dried from the roots of Jognifolia. The name “Seshin” comes from the fact that the root is extremely thin and has a very spicy taste. The two incense names were called Sesim, and they were also called God and Secho. Aphid is a perennial herbaceous plant belonging to the Rataceae family. The rhizome has many nodes, and two leaves come out and spread out from the end of the main stem. The leaves are heart-shaped, 5-10 cm wide, and the edges are flat. The flowers are reddish-purple, and when the leaves are about to come out, they come out one by one between the leaves. The fruit is berry-like, has an inflorescence lobe at the end, and contains about 20 seeds. The roots are collected from May to July and dried in the shade. Weakness is mild and the taste is spicy. Efficacy: When the nose is blocked by a cold or runny nose continues to flow, secretions are continuously discharged from the throat area, and sweating is difficult, pathogens are discharged outside the body. It is also essential when the fever is severe due to a cold, and the headache is severe and unbearable. It also acts as an antitussive when coughing heavily while excreting a large amount of phlegm due to chronic bronchitis or bronchiectasis.

It is also referred to as the dumplings. It is 1.5m high and has some hairs all over except for flowers. It is called solitary, meaning it does not move in the wind. The young shoots in early spring are edible, and after the leaves die in the fall, cover with soil so that the young shoots can grow longer. The root is medicinal, and it is widely used for muscle pain, paralysis of the lower body, headache, and paralysis of the body. It is distributed in the mountainous regions of East Asia.

Windbreak means that it blocks the wind, and it is a very important medicine in the treatment of wind diseases. The word folding screen has a similar meaning and is used as a pseudonym, and because of the strong scent of flowers, it has been compared to orchids or mugwort. The windbreak is cylindrical, and the lower part is slightly thin. The outer surface is light brown, and the upper part of the rhizome has densely spheroid-shaped vertical folds, and some brown hair-like residues of leaf sheaths are attached. The root has many longitudinal wrinkles and fine root marks. There are a lot of fine hairs like a brush on the head of the brain, and there are radial patterns. It has a peculiar smell, and the weakness is spicy, sweet, and warm. Windbreak is effective for all types of wind sickness, including external headache, chills, fever, generalized pain, and sore throat. It is used for joint pain in the extremities of wind and cold, tetanus, muscle spasms, hemiplegia due to stroke, paralysis pain, itching of the skin, and ringworm. As pharmacological actions, antipyretic, anti-inflammatory, antispasmodic, immune activation, anti-allergy, anti-ulcer, antibacterial, and skin-improving bacteria suppression have been reported.

Persimmon vinegar is used by adding honey to raw licorice and stir-frying it over a fire. it is medicine

The amount of herbal ingredients in the herbal complex in step 1 used for preparing the composition of the present invention is per 100 parts by weight of ginseng, 90 to 110 parts by weight of leaflets, 90 to 110 parts by weight of hyeonggae, 90 to 110 parts by weight of ephedra, 90 to 110 parts by weight of passersby. It is recommended to use parts by weight, 90 to 110 parts by weight of chawan, 60 to 70 parts by weight of sesame, 60 to 60 parts by weight of poison, 60 to 70 parts by weight of windbreak, and 30 to 40 parts by weight of persimmon vinegar.

Next, step 2 is a step of preparing a mixed solution by adding the herbal compound of step 1 to the extraction solvent and sufficiently stirring at 25 to 30 ° C. In this case, 4 liters to 6 liters of the extraction solvent per 1 kg of the herbal complex are used. It is preferable to use 4.5 liters to 5.5 liters of the extraction solvent per 1 kg of the herbal complex, and more preferably, about 5 liters of the extraction solvent per kg of the herbal complex. At this time, if the amount of extraction solvent used is less than 3 liters, the amount of extraction solvent used is too small, and the extraction solvent evaporates too quickly during distillation in step 3, which may make it difficult to extract the active ingredient. It takes too long and there may be uneconomic problems, so it is better to use it within the above range. In this case, it is preferable to use distilled water as the extraction solvent.

Next, step 3 is a process of heating a mixed solution in which the herbal compound and the extraction solvent are mixed to extract the active extract ingredients in the herbal compound, and distilling the solvent to prepare a concentrated extract. Heating and distillation are the volume of the mixed solution It is preferable to perform so that Equation 1 below is satisfied.

[Equation 1]

15% ≤ {(volume of mixed solution before heating-volume of extract after heating)/volume of mixed solution before heating*100%} ≤ 20%, preferably 16.5% ≤ {(volume of mixed solution before heating-volume of extract after heating)/ Volume of mixed solution before heating*100%} ≤ 20.0%

At this time, the heating temperature is preferably 75 ~ 90 ℃, preferably heating to 80 ~ 85 ℃, if the heating temperature exceeds 90 ℃, the ethanol component evaporates too quickly, the active ingredient may not be sufficiently extracted, heating If the temperature is less than 75 ℃, there may be a problem in that the extraction of the active ingredient is rather difficult, and the process for preparing the extract through distillation is too long.

Next, step 4 is a process of obtaining the essence from the concentrated extract by filtering the extract concentrated in step 3 in a general way.

The herbal composition for alleviating or treating rhinitis of the present invention prepared in this way is applied as an herbal medicinal solution or injection, and is administered directly through the skin rather than orally, thereby relieving rhinitis faster and more effectively than conventional oral rhinitis treatment drugs and/or can be treated

In addition, the herbal medicinal solution and/or injection solution may further include a lubricant, emulsifier, suspending agent, preservative, etc. harmless to the human body.

And, to give a preferred example of acupuncture using the herbal composition for alleviating or treating rhinitis of the present invention, the composition is used as an oriental medicinal acupuncture solution, and the oriental medicinal acupuncture injection device is filled with the oriental medicinal acupuncture solution, followed by acupuncture with excellent effect on rhinitis Acupuncture can be performed by injecting the herbal composition into the seat, cheondol.

Hereinafter, the present invention will be described in more detail through examples. These examples are for illustrating the present invention, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not to be construed as being limited by these examples.

[실시예][Example]

실시예 1 : 비염 완화 및/또는 치료용 생약 조성물 제조Example 1: Preparation of herbal composition for alleviation and/or treatment of rhinitis

(1) 생약 복합물의 준비(1) Preparation of herbal complexes

Per 100 parts by weight of ginseng, 90-110 parts by weight of leaflets, 90-110 parts by weight of Hyeonggae, 90-110 parts by weight of ephedra, 90-110 parts by weight of ginseng, 90-110 parts by weight of jawan, 60-70 parts by weight of ginseng, 60 parts by weight of poison The mixture was prepared in a ratio of ~ 60 parts by weight, 60 to 70 parts by weight of windbreak, and 30 to 40 parts by weight of persimmon vinegar.

(2) 진액 제조(2) Preparation of extract

A mixed solution was prepared by mixing 5 liters of distilled water per 1 kg of the herbal complex. Next, the mixed solution was stirred and heated to 80 to 82° C., and the mixture was heated and distilled until the volume of the mixed solution satisfies Equation 1 below to obtain a concentrated extract.

[Equation 1]

17.5% ≤ ≤ {(volume of mixed solution before heating - volume of extract after heating)/volume of mixed solution before heating*100%} ≤ 18.0%

Next, the concentrated extract was filtered to prepare a herbal composition for alleviating and/or treating rhinitis, which is the essence.

제조예 1 : 주사제의 제조Preparation Example 1: Preparation of injection

The herbal composition prepared in Example 1 was mixed with sterile physiological saline (N/S) (Lot No.: 12062, source: JW Pharmaceutical) and diluted to a concentration of 35% by volume to prepare an injection.

실험예 1 : 약침 시술을 통한 비염 완화 효과 측정Experimental Example 1: Measurement of rhinitis relief effect through medicinal acupuncture treatment

It was prepared without dilution of the herbal composition prepared in Example 1 as a medicinal acupuncture liquid for oriental medicinal acupuncture. In addition, acupuncture was performed on 10 patients with rhinitis using the herbal acupuncture solution, and acupuncture was performed on the acupuncture point, Baekhohyeol. Pharmacupuncture acupuncture was performed 3 times a week for 3 weeks, and it was checked whether the patient's rhinitis was alleviated or not, and the results are shown in Table 1 below.

구분division	1주차1 week	2주차2nd week	3주차3 weeks
매우 완화very relaxed	33	55	88
완화ease	33	33	22
약간 완화slightly relieved	44	22	00
변화없음no change	00	00	00

Through the above experiment, it was confirmed that rhinitis could be alleviated to a significant extent through acupuncture using acupuncture with oriental medicinal acupuncture of the present invention. It is expected to be able to treat rhinitis.

Claims

A herbal medicine for relieving or treating rhinitis, containing as an active ingredient the extract obtained by distilling an extract obtained by extracting a herbal complex including ginseng, leaflet, hyeonggae, ephedra, ginseng, jawan, sessin, poison ivy, persimmon, persimmon and licorice as an extractant. composition.
According to claim 1,

The crude drug complex is per 100 parts by weight of ginseng, 90 to 110 parts by weight of leaflets, 90 to 110 parts by weight of Hyeonggae, 90 to 110 parts by weight of ephedra, 90 to 110 parts by weight of passersby, 90 to 110 parts by weight of Jawan, 60 to 70 parts by weight of Seshin. A herbal composition for alleviating or treating rhinitis comprising parts, 60-60 parts by weight of poison, 60-70 parts by weight of windbreak, and 30-40 parts by weight of persimmon vinegar.
According to claim 1,

The extraction solvent is distilled water, and 4 liters to 6 liters per 1 kg of the herbal complex are used. A herbal composition for alleviating or treating rhinitis.
Step 1 of preparing a herbal complex including ginseng, leaflet, hyeonggae, ephedra, haengin, jawan, sesin, sookhwal, windbreak, licorice;

a second step of preparing a mixed solution by adding the herbal complex to an extraction solvent and then stirring;

Step 3 of heating the mixed solution to obtain a concentrated extract by distilling the mixed solution;

A method of preparing a herbal composition for alleviating or treating rhinitis, comprising performing a process comprising a; 4 step of filtering the concentrated extract to obtain the essence.
[Claim 4] An herbal medicinal solution comprising the herbal composition for alleviating or treating rhinitis according to any one of claims 1 to 3.
An injection comprising the herbal composition for alleviating or treating rhinitis according to any one of claims 1 to 3.
A medicinal acupuncture method in which acupuncture is performed on white tiger blood or pulmonary blood transfusion, which is an acupuncture point, with oriental medicinal acupuncture applied with the herbal medicinal acupuncture solution of claim 5.