WO2021103777A1

WO2021103777A1 - Spraying agent for preventing and treating allergic asthma combined with allergic rhinitis in children and teenagers

Info

Publication number: WO2021103777A1
Application number: PCT/CN2020/116449
Authority: WO
Inventors: 赵天抒; 李华京; 王静
Original assignee: 垒途智能教科技术研究院江苏有限公司; 南京中垒科技发展有限公司
Priority date: 2019-11-25
Filing date: 2020-09-21
Publication date: 2021-06-03
Also published as: CN110917271A

Abstract

Disclosed is a spraying agent for preventing and treating allergic asthma combined with allergic rhinitis in children and teenagers. The spraying agent comprises pharmaceutical ingredients and auxiliary materials. The pharmaceutical ingredients comprise volatile oils and a traditional Chinese medicine extract, wherein the volatile oils comprise Annona squamosa seed volatile oil, Citri reticulatae pericarpium volatile oil, Aquilariae lignum resinatum volatile oil, Perillae fructus volatile oil, Lonicerae japonicae flos volatile oil and Borneolum syntheticum; and the traditional Chinese medicine extract is prepared from Sinapis alba, Chrysanthemi flos, Viticis fructus, Ampelopsis grossedentata, Puerariae lobatae radix, Scutellariae radix, Ephedrae herba preparata, fried Xanthii fructus, Polygoni cuspidati rhizoma et radix and Salviae miltiorrhizae radix et rhizoma.

Description

Spray for preventing and treating allergic asthma combined with allergic rhinitis in children and adolescents

Technical field

The invention specifically relates to a spray used for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents.

Background technique

Allergic rhinitis asthma (Combined Allergic Rhinitis and Asthma Syndrome.CARAS) refers to the simultaneous occurrence of clinical or subclinical upper respiratory tract allergy (allergic rhinitis) and lower respiratory tract allergic symptoms (asthma), both of which often coexist at the same time. The immunological and pathological changes of the upper and lower respiratory tracts of allergic rhinitis and asthma are allergic inflammation of the nasal mucosa and bronchial mucosa, respectively. Inflammation of nasal mucosa and bronchial mucosa is very similar in terms of pathogenic factors, genetic changes, local pathological changes, abnormal immune function and pathogenesis.

The incidence of allergic asthma combined with allergic rhinitis in children and adolescents is increased. Repeated attacks can damage lung function and aggravate airway damage. It has a serious impact on children's learning, daily activities and even growth and development, and it also brings heavy burden to family and society. burden.

The existing drugs are mainly treated with nasal hormones, oral or nasal antihistamines, etc., but the long-term effect is not very satisfactory, and the side effects of long-term use are relatively large.

Summary of the invention

The purpose of the present invention is to aim at the pathogenesis characteristics of children and adolescents with allergic asthma combined with allergic rhinitis, provide a portable and easy to use, can effectively improve the physical state of children with allergies, and can safely and effectively treat children with allergies Sprays for rhinitis and asthma.

In order to achieve the above objectives, the specific technical solutions adopted by the present invention are as follows:

A spray for the prevention and treatment of children and adolescents with allergic asthma and allergic rhinitis, which includes pharmaceutical ingredients and auxiliary materials; the pharmaceutical ingredients include volatile oil and Chinese medicine extracts: the volatile oil is made from the following raw materials:

Annona seed volatile oil, tangerine peel volatile oil, agarwood volatile oil, perilla volatile oil, honeysuckle volatile oil, borneol;

The Chinese medicine extract is prepared from the following raw materials:

White mustard seeds, chrysanthemum, vitex, Maoyan berry tea, kudzu root, scutellaria, dense ephedra, fried cocklebur, knotweed and salvia.

As a preferred solution, the above-mentioned spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents, which includes pharmaceutical ingredients and auxiliary materials;

The pharmaceutical ingredients include volatile oil and Chinese medicine extracts: the volatile oil is prepared from the following raw materials:

Annona seed volatile oil 3-12 parts, tangerine peel volatile oil 3-12 parts, agarwood volatile oil 1-6 parts, perilla volatile oil 2-8 parts, honeysuckle volatile oil 3-12 parts, borneol 1-3 parts;

The Chinese medicine extract is prepared from the following raw materials:

5-15 parts of white mustard seeds, 6-18 parts of chrysanthemum, 5-15 parts of vitex, 5-15 parts of Maoyanberry tea, 5-15 parts of kudzu root, 6-18 parts of scutellaria, 5-15 parts of dense ephedra, Stir-fried Xanthium spp. 3-9 parts, Polygonum cuspidatum 3-9 parts, and Salvia miltiorrhiza 3-9 parts.

9 parts of annona seed essential oil, 6 parts of tangerine peel essential oil, 3 parts of agarwood essential oil, 6 parts of perilla essential oil, 6 parts of honeysuckle essential oil, 1 part of borneol;

The Chinese medicine extract is prepared from the following raw materials:

10 parts of white mustard seeds, 18 parts of chrysanthemum, 10 parts of vitex, 15 parts of Maoyan berry tea, 15 parts of Pueraria lobata, 12 parts of scutellaria, 15 parts of dense ephedra, 6 parts of sauteed cocklebur, 6 parts of Polygonum cuspidatum, and 6 parts of Danshen .

The spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents of the present invention, wherein the auxiliary materials include ethanol, 1,3-propanediol, and purified water. The volume ratio of 1,3-propanediol and purified water is 1-2:1-2:10.

As a preferred solution, the above-mentioned spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents, wherein the weight percentage of the pharmaceutical ingredients is 5-15%.

The spray for the prevention and treatment of allergic asthma in children and adolescents combined with allergic rhinitis according to the present invention, the essential oil of annona seed, the essential oil of tangerine peel, the essential oil of agarwood, the essential oil of perilla and the essential oil of honeysuckle all adopt steam distillation or super Extracted by critical extraction method. When extracting by steam distillation, add 8 to 10 times the amount of water, use steam distillation device, extract for 2 hours, and collect the volatile oil.

In the spray used for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents of the present invention, the preparation method of the traditional Chinese medicine extract includes the following steps:

According to the weight ratio, take white mustard seeds, chrysanthemums, vitex seeds, Maoyan berry tea, kudzu root, scutellaria, dense ephedra, fried cocklebur, knotweed and salvia, add 6-15 times the total weight of the medicinal materials with water, and decoct Boil and extract 1 to 2 times, 1 to 1.5 hours each time, combine the extracts and concentrate to obtain.

Preferably, the preparation method of traditional Chinese medicine extract includes the following steps:

According to the weight ratio, take white mustard seeds, chrysanthemums, vines, Maoyan berry tea, kudzu root, scutellaria, fried cocklebur seeds, dense ephedra, knotweed and salvia, and add water 10 times the total weight of the medicinal materials for the first time. Decoction and extraction for 1.5 hours, add water 8 times the total weight of the medicinal material for the second time, decoction and extraction for 1 hour, combine the extracts, and concentrate to obtain.

The invention uses white mustard seeds after long-term tests, which are pungent, warm and non-toxic. Go nose. Mainly eliminates kidney evil qi, helps nine orifices, improves eyes and ears, warms the lungs, eliminates phlegm and promotes qi. It is used for cold phlegm, asthma and cough, chest pain, phlegm stagnation in the meridian, numbness and pain of joints, phlegm dampness flow, swollen syringe and poison.

Chrysanthemum belongs to lung and liver meridian. It has the effects of dispelling wind-heat, calming the liver and improving eyesight, clearing away heat and detoxification. Indications: wind-heat and cold, fever, headache, dim eyesight, clearing wind and heat, clearing liver and fire, clearing heat and detoxification, etc.

Vitex quinquefolia has a pungent, bitter taste and slightly cold in nature. Return to lung, bladder, liver meridian. Frivolity Shengsan This product can disperse wind, clear away heat from slight cold, frivolity ascends, mainly disperses the evil of the head and face, has the effect of dispelling wind and relieving pain, and is used to treat exogenous wind-heat, headache and dizziness.

The invention is innovatively added with Maoyan berry tea, which is a vine tea variety that grows and multiplies in the specific geographical and climatic environment of Zhangjiajie, and belongs to a deciduous vine (Vitis). After testing and identification, the plant contains a natural plant cream, the active ingredient is mainly flavonoids, containing flavonoid crude protein 12.8 ~ 13.8, the average content of total flavonoids is ≥6%, the highest detected content is 9.37%, which is all found so far Plants have the highest content of flavonoids, so they are called the "king of flavonoids" (flavonoids are known as "vascular scavengers" in medical circles, and they are the new favorite for the prevention of cardiovascular and cerebrovascular diseases). It is rich in 17 kinds of amino acids and 14 kinds of trace elements including potassium, calcium, iron, zinc and selenium. The main flavonoids of Maoyan Berry Tea, dihydroxymycin, has anti-bacterial and anti-inflammatory properties, clearing away heat and detoxification, relieving pain, reducing swelling, moistening throat and relieving cough, Improve human immunity, anti-allergic and other functions.

Pueraria lobata, sweet, pungent, and cold. It has the functions of relieving muscles and reducing fever, removing rash, producing body fluid to quench thirst, and promoting Yang to stop diarrhea. It is often used for symptoms of fever, strong nape and back pain, impervious measles, thirst due to fever, yin deficiency to reduce thirst, heat diarrhea and heat dysentery, spleen deficiency and diarrhea.

Scutellaria baicalensis is used for heat-clearing, detoxifying and dampness, mainly treating febrile diseases, for children's body heat, used for damp heat, chest tightness, thirst and unwilling to drink, etc.

Xanthium is pungent, bitter, warm in nature, and poisonous. Return to the lung meridian. It has the functions of dispersing wind, removing dampness, and relieving pain. Indications: dispersing wind-cold, clearing nose and orifices, and dispelling rheumatism.

Ephedra mainly contains ephedrine, which is warm in nature, pungent in taste and slightly bitter. It has the effects of sweating and dispelling cold, promoting lung and asthma, diuresis and swelling. It can treat cold, cold, chest tightness, cough, wind swelling, bronchial asthma and other diseases.

Polygonum cuspidatum has a slightly bitter taste, slightly cold in nature, and belongs to the liver, gallbladder and lung meridians. It has the German effect of eliminating dampness and relieving yellow, clearing heat and detoxification, dispelling blood stasis and relieving pain, relieving cough and resolving phlegm. It can be used for lung-heat cough, rheumatism arthralgia, carbuncle swelling and sore toxin, water and fire burns, amenorrhea, symptom and rash injuries.

Salvia miltiorrhiza contains tanshinone, which is a strong meridian, which has the equivalent functions of removing blood stasis, regenerating new life, and promoting blood circulation. The addition of salvia in the present invention can help promote blood circulation and has a better auxiliary effect on lung asthma and allergies.

The above formulas of various medicinal flavors are compatible with specific volatile oils, which can achieve the effects of dispelling wind and dehumidification, resuscitating, detoxifying, anti-allergic, promoting lung and asthma, promoting dampness and strengthening spleen, etc. It is very good for children and adolescents with allergic asthma and allergic rhinitis. Control effect.

Beneficial effects: According to the pathogenesis characteristics of children and adolescents with allergic asthma combined with allergic rhinitis, the present invention adopts the volatile oil components of the preferred composition and the preferred traditional Chinese medicine extract components, and has the functions of dispelling wind and resuscitation, relieving the lungs and relieving asthma, dispelling wind, and expelling evil spirits. , Detoxification, cooling blood and promoting blood circulation, etc., can relieve external evils, clear the lung orifices, and achieve the effect of clearing the nose orifices. It has a good anti-allergic asthma and rhinitis effect, and through volatile components and traditional Chinese medicine extracts Nasal spray is easier to absorb until the capillaries of the nose and lungs, and the effect is quicker.

Detailed ways

The present invention will be further clarified below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. After reading the present invention, those skilled in the art will understand various equivalent forms of the present invention. All modifications fall within the scope defined by the appended claims of this application.

In the following examples, the volatile oil of annona seed, the volatile oil of tangerine peel, the volatile oil of agarwood, the volatile oil of perilla, and the volatile oil of honeysuckle are all obtained by the following methods:

Take the dried annona seeds, tangerine peel, agarwood, perilla leaves or honeysuckle, respectively, and place them in a volatile oil extractor, add 10 times the amount of water, and use steam distillation to extract for 2 hours, and then collect the lychee seed volatile oil. , Tangerine peel volatile oil, agarwood volatile oil, perilla volatile oil, honeysuckle volatile oil.

Example 1

A spray for the prevention and treatment of children and adolescents with allergic asthma combined with allergic rhinitis, which includes pharmaceutical ingredients and auxiliary materials (ethanol:1,3-propanediol:purified water volume ratio 1:2:10); the pharmaceutical ingredients account for The weight percentage of the volatile oil is 8%; the pharmaceutical ingredients are made of volatile oil and traditional Chinese medicine extracts: the volatile oil is obtained by combining the following components:

Annona seed volatile oil 9g, tangerine peel volatile oil 6g, agarwood volatile oil 3g, perilla volatile oil 6g, honeysuckle volatile oil 6g, and borneol 1g;

The Chinese medicine extract is prepared from the following raw materials:

10g of white mustard seeds, 18g of chrysanthemum, 10g of vitex, 15g of Maoyan berry tea, 15g of kudzu root, 12g of scutellaria, 15g of dense ephedra, 6g of fried xanthium, 6g of knotweed and 6g of salvia.

The described Chinese medicine extracts are all prepared by the following methods:

According to the weight ratio, take 10g of white mustard seed, 18g of chrysanthemum, 10g of vitex, 15g of Maoyanberry tea, 15g of kudzu root, 12g of scutellaria, 15g of dense ephedra, 6g of fried cocklebur, 6g of knotweed and 6g of salvia. Add water 10 times the total weight of the medicinal materials, decoct and extract for 1.5 hours, add 8 times the total weight of the medicinal materials for the second time, decoct and extract for 1 hour, combine the extracts, and concentrate to obtain the extract.

Example 2

Annona seed volatile oil 3g, tangerine peel volatile oil 6g, agarwood volatile oil 1g, perilla volatile oil 6g, honeysuckle volatile oil 6g, borneol 1g;

The Chinese medicine extract is prepared from the following raw materials:

White mustard seeds 5g, chrysanthemum 18g, vitex 5g, Maoyan berry tea 5g, kudzu root 15g, scutellaria 12g, dense ephedra 15g, fried cocklebur 6g, polygonum cuspidatum 6g and salvia 6g.

According to the weight ratio, take 5g of white mustard seed, 18g of chrysanthemum, 10g of vitex, Maoyanberry tea 5g, kudzu root 15g, scutellaria 12g, dense ephedra 15g, fried cocklebur 6g, polygonum cuspidatum 6g and salvia 3g, for the first time Adding 10 times the total weight of the medicinal materials with water, decocting and extracting for 2 hours, adding 8 times the total weight of the medicinal materials for the second time, decocting and extracting for 1 hour, combining the extracts, and concentrating to obtain the extract.

Comparative Example 1

A spray for the prevention and treatment of children and adolescents with allergic asthma combined with allergic rhinitis, which includes pharmaceutical ingredients and auxiliary materials (ethanol:1,3-propanediol:purified water volume ratio 1:2:10); the pharmaceutical ingredients account for The weight percentage of is 8%; the pharmaceutical ingredient is volatile oil: the volatile oil is obtained by combining the following components:

Annona seed volatile oil 9g, tangerine peel volatile oil 6g, agarwood volatile oil 2g, perilla volatile oil 6g, honeysuckle volatile oil 6g, and borneol 1g.

Comparative Example 2

A spray for the prevention and treatment of children and adolescents with allergic asthma combined with allergic rhinitis, which includes pharmaceutical ingredients and auxiliary materials (ethanol:1,3-propanediol:purified water volume ratio 1:2:10); the pharmaceutical ingredients account for The weight percentage is 8%; the Chinese medicine extract is made from the following raw materials:

Example 3 Clinical observation experiment of allergic asthma combined with allergic rhinitis

(1) Selection of test cases for allergic asthma combined with allergic rhinitis: refer to the diagnostic criteria for allergic asthma and allergic rhinitis (diagnostic criteria for allergic asthma: refer to the "Guidelines for the Prevention and Treatment of Bronchial Asthma" formulated by the Asthma Group of the Respiratory Branch of the Chinese Medical Association (2008) "Selected 40 patients with allergic asthma and allergic rhinitis randomly divided into the treatment group of Example 1, Example 2 and the control group 1, the control group 2 control group. 40 patients with allergic asthma and allergic rhinitis, 22 males and females There were 18 cases, aged 3-15 years, with an average of 8±1.2 years old. There was no statistical difference in gender, age, and course of disease between the two groups.

(3) Treatment method: The treatment group was sprayed with the sprays of Example 1 and Example 2 every day, 3 times a day, 2 ml each time. The control group 1 and the control group 2 were sprayed with the sprays of the control group 1 and the control group 2 respectively every day, 3 times a day, 2 ml each time. The treatment effect was evaluated after 3 months of medication.

(4) Evaluation of treatment effect: Observe the treatment effect after 1 month of treatment.

①Asthma control score: 25 points for complete asthma control, 20-24 points for good asthma control, and less than 20 points for uncontrolled asthma.

②Rhinitis symptom scoring standard: A. Refer to the allergic rhinitis scoring standard in "Allergic Rhinitis Handling Pocket Reference 2009" to evaluate the patient's symptoms.

B. RQLQ score scale: score before and after treatment.

③Detection of total serum IgE: fasting venous blood, test IgE content with kit.

④Evaluation index of the curative effect of allergic rhinitis: the improvement rate is calculated by [(total score before treatment-total score after treatment)/total score before treatment]*100%, among which, markedly effective ≥ 51%; effective ≤ 50%, ≥ 21%; Invalid ≤ 20%.

⑤Total effective rate: Effective: Asthma score is 20 points or more, meanwhile, allergic rhinitis curative effect evaluation index ≥51%; improvement: Asthma score is 20-24 points, and allergic rhinitis curative effect evaluation index ≤50%, ≥21% ; Invalid: Asthma <20 points, meanwhile, the evaluation index of curative effect of allergic rhinitis ≤20%.

(5) Results: The collected data is statistically analyzed using SPSS 18.0 software. The results of asthma control score and rhinitis symptom score are shown in Table 1, and the results of RQLQ score and serum total IgE index are shown in Table 2. The results show that Example 1 and Example 2 of the present invention have better efficacy in treating asthma and rhinitis compared to Examples 1 and 2 of the control group.

The effective rate of Example 1 of the present invention is 90%, and the effective rate of the treatment group of Example 2 is 80%, which is significantly higher than that of the control group 1 (effective rate of 20%) and control group 2 (effective rate of 30%). The specific results are shown in Table 3. .

Table 1 Comparison of asthma control score and rhinitis symptom score index between the two groups of patients before and after treatment (points,

)

**P<0.001 compared with before treatment, *P<0.05 compared with before treatment

Table 2 Comparison of RQLQ scores and serum total IgE indexes between the two groups of patients before and after treatment (points,

)

Table 3 Comparison of the total treatment effect of the two groups of patients (cases)

Group	Number of cases	effective	Get better	invalid	Total effective rate
Example 1	10	8	1	1	90%
Example 2	10	7	3	2	80%
Comparative Example 1	10	0	2	8	20%
Comparative Example 2	10	0	3	7	30%

.

The above clinical test results show that the spray provided by the present invention has a good therapeutic effect on allergic asthma combined with allergic rhinitis, and through comparative experiments, it is found that the present invention is effective in reducing the volatile oil of annon-apple seeds, scented volatile oil, and white mustard seeds. When the content of Cranberry and Maoyanberry tea, the therapeutic effect is reduced. When the spray dose is the same, when compared with a single volatile oil component or a single Chinese medicine extract component, when the volatile oil and the Chinese medicine extract are used together, it shows a more significant effect on the treatment of allergic asthma and allergic rhinitis, indicating that each component Supplement each other and play a synergistic role.

Example 4 Experimental observation on asthma model mice

(1) Reagents and experimental drugs

IL-5 and IL-13 kits were purchased from Hangzhou Lianke Biotechnology Co., Ltd.

Test drugs: Example 1, Example 2, Control Example 1 and Control Example 2, which were administered by spray;

(2) Experimental animals

km mice, 4-6 weeks old, female, SPF grade, provided by Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing.

(3) Experimental method

(3.1) Modeling

The mice were randomly divided into 6 groups, normal group, model group, example 1, example 2, control group 1, and control group 2. After purchase, model group, example 1, example 2, control group 1 and control group 2 were intraperitoneally injected with 0.4ml OVA sensitizing solution (from OVA 2g, aluminum hydroxide gel 20ml, physiological saline 20ml on day 0 and day 7, respectively). Preparation) for sensitization, the normal group was intraperitoneally injected with the same amount of saline. And on the 14th day, the 5% OVA solution was sprayed and inhaled for 30 minutes for excitation, and continuously sprayed for 5 days, once a day, for 30 minutes each time. The mice in the normal group were atomized with the same amount of normal saline.

(3.1) Administration

Example 1, Example 2, the control group 1 and the control group 2 were all administered by atomized spray, 2 ml each time, 3 times a day, and sprayed continuously for 7 days.

(3.2) Experimental specimen collection

24 hours after the last nebulization (during the mice fasting without water), blood was taken from the eyeball after anesthesia, and then sacrificed by cervical dislocation. Four of them were taken with alveolar lavage fluid and stored at -80°C; the other four were cut from the right middle lung and fixed in 4% paraformaldehyde, and the remaining lung tissue was stored at -80°C for use.

(4) Experimental results

(4.1) Pulmonary pathological inflammation: Compared with the normal group, the bronchial tube wall of the model group is thickened, the alveolar wall is thickened, and the inflammatory cell infiltration is obvious in the model group. After the sprays of Example 1 and Example 2 of the present invention were administered, the lung tissue inflammation infiltration and luminal secretion of mice were significantly reduced, and the effect of Example 1 was better than that of Example 2, while the comparative examples 1 and 2 were less effective. Inflammation infiltration and luminal secretion of rat lung tissue were alleviated, but not obvious.

(4.2) The expression of IL-4, IL-5 and IL-13 inflammatory factors in alveolar lavage fluid.

The specific results are shown in Table 4. Compared with the normal group, the levels of IL-4, IL-13 and IL-5 in the model group were significantly increased. After the sprays of Examples 1 and 2 were given, IL-4, IL-13 and IL -5 levels were significantly reduced, and the difference was statistically significant (P<0.05). Comparative Examples 1 and 2 have a certain effect on reducing the levels of IL-13 and IL-5, but they are not statistically significant (P>0.05).

Table 4 The expression of IL-4, IL-5, IL-13 inflammatory factors in each group

组别Group	IL-5(pg/mL)IL-5(pg/mL)	IL-4(ng/mL)IL-4(ng/mL)	IL-13(pg/mL)IL-13(pg/mL)
正常组normal group	5353	23twenty three	4343
模型组Model group	138#138#	43#43#	68#68#
实施例1Example 1	6060	2626	4646
实施例2Example 2	6363	2727	4949
对照实施例1Comparative Example 1	8080	3737	6262
对照实施例2Comparative Example 2	7676	3535	5959

#Compared with normal group, *Compared with before treatment P＜0.05

Example 5

Case one

Yu ××, female, 7 years old

Main complaint: nasal itching and nasal congestion intercropped for 1 year.

History of present illness: The child has repeated nasal itching and nasal congestion in the past 2 years, sneezing in the morning, nasal itching, and nasal congestion, and coughing and asthma at night intensify, occasionally. Lack of sleep soundly, stools once every 1-2 days, dry.

Physical examination: the tonsils were swollen at II°, and lymphoid follicle hyperplasia was seen on the back wall of the pharynx. The tongue is dark red and the fur is white.

Diagnosis: Western medicine: Allergic rhinitis with asthma

Prescription: Use the spray of Example 1 to spray, 3 times a day, 2 mL each time.

After 4 weeks of continuous spray treatment, the patient will be re-diagnosed for nasal itching, nasal congestion, night cough and asthma, better than before, good appetite, bowel movements, and the tongue is dull and red.

Case two

Li ××, male, 6 and a half years old

Main complaint: itchy nose, sneezing with runny nose for more than 3 months, accompanied by night cough and asthma.

History of present illness: The child developed nasal itching, sneezing, and nighttime intermittent asthma and coughing, lack of sleep soundness, and dry stools.

Physical examination: breath sounds normal on auscultation of the lungs. The tongue is red and the fur is thin and white.

Diagnosis: Western medicine: Allergic rhinitis combined with asthma.

After 4 weeks of continuous spray treatment: the child got up in the morning, sneezing, nasal itching, and coughing alleviated, runny nose was not obvious, sleep soundly, two bowel movements, red tongue, thin coating.

Claims

A spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents, which is characterized in that it includes pharmaceutical ingredients and auxiliary materials;

The pharmaceutical ingredients include volatile oil and Chinese medicine extracts: the volatile oil is prepared from the following raw materials:

Annona seed volatile oil, tangerine peel volatile oil, agarwood volatile oil, perilla volatile oil, honeysuckle volatile oil, borneol;

The Chinese medicine extract is prepared from the following raw materials:

White mustard seeds, chrysanthemum, vitex, Maoyan berry tea, kudzu root, scutellaria, dense ephedra, fried cocklebur, knotweed and salvia.
The spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents according to claim 1, characterized in that it comprises pharmaceutical ingredients and auxiliary materials;

The pharmaceutical ingredients include volatile oil and Chinese medicine extracts: the volatile oil is prepared from the following raw materials:

Annona seed volatile oil 3-12 parts, tangerine peel volatile oil 3-12 parts, agarwood volatile oil 1-6 parts, perilla volatile oil 2-8 parts, honeysuckle volatile oil 3-12 parts, borneol 1-3 parts;

The Chinese medicine extract is prepared from the following raw materials:

5-15 parts of white mustard seeds, 6-18 parts of chrysanthemum, 5-15 parts of vitex, 5-15 parts of Maoyan berry tea, 5-15 parts of kudzu root, 6-18 parts of scutellaria, 5-15 parts of dense ephedra, Stir-fried Xanthium spp. 3-9 parts, Polygonum cuspidatum 3-9 parts, Salvia miltiorrhiza 3-9 parts.
The spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents according to claim 2, characterized in that:

It includes pharmaceutical ingredients and excipients;

The pharmaceutical ingredients include volatile oil and Chinese medicine extracts: the volatile oil is prepared from the following raw materials:

9 parts of annona seed essential oil, 6 parts of tangerine peel essential oil, 3 parts of agarwood essential oil, 6 parts of perilla essential oil, 6 parts of honeysuckle essential oil, 1 part of borneol;

The Chinese medicine extract is prepared from the following raw materials:

10 parts of white mustard seeds, 18 parts of chrysanthemum, 10 parts of vitex, 15 parts of Maoyan berry tea, 15 parts of Pueraria lobata, 12 parts of scutellaria, 15 parts of dense ephedra, 6 parts of fried cocklebur, 6 parts of Polygonum cuspidatum, 6 parts of Danshen .
The spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents according to any one of claims 1 to 3, wherein the auxiliary materials include ethanol, 1,3-propanediol, and purified water.
The spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents according to any one of claims 1 to 3, characterized in that the essential oil of annona seed, essential oil of tangerine peel, essential oil of agarwood, essential oil of perilla And honeysuckle volatile oil is obtained by steam distillation or supercritical extraction.
The spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents according to any one of claims 1 to 3, characterized in that the preparation method of the Chinese medicine extract comprises the following steps:

According to the weight ratio, take white mustard seeds, chrysanthemums, vitex seeds, Maoyan berry tea, kudzu root, scutellaria ephedra, sauteed cocklebur, knotweed and salvia, add 6-15 times the total weight of the medicinal materials in water, and decoct Extract 1 to 2 times, 1 to 1.5 hours each time, combine the extracts and concentrate to obtain.
The spray for the prevention and treatment of allergic asthma combined with allergic rhinitis in children and adolescents according to claim 6, characterized in that the preparation method of the Chinese medicine extract comprises the following steps:

According to the weight ratio, take white mustard seeds, chrysanthemums, vitex seeds, Maoyan berry tea, kudzu root, scutellaria, dense ephedra, fried cocklebur, knotweed and salvia, and add water 10 times the total weight of the medicinal materials for the first time. Decoction and extraction for 1.5 hours, add 8 times the total weight of the medicinal material for the second time with water, decoction and extraction for 1 hour, combine the extracts, and concentrate to obtain.