CN104548024A - Externally-applied medicine for treating combined allergic rhinitis and asthma syndrome - Google Patents

Externally-applied medicine for treating combined allergic rhinitis and asthma syndrome Download PDF

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CN104548024A
CN104548024A CN201510003229.5A CN201510003229A CN104548024A CN 104548024 A CN104548024 A CN 104548024A CN 201510003229 A CN201510003229 A CN 201510003229A CN 104548024 A CN104548024 A CN 104548024A
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allergic rhinitis
medicine
asthma
asthma syndrome
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张丽美
李莹
陆永辉
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Shandong Academy of Chinese Medicine
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract

The invention discloses an externally-applied medicine for treating combined allergic rhinitis and asthma syndrome, and belongs to the technical field of traditional Chinese medicines. The medicine is prepared from the following raw medicines in parts by weight: 10 to 20 parts of cocklebur fruit, 10 to 14 parts of ligusticum, 10 to 15 parts of caulis spatholobi, 10 to 20 parts of asarum, 10 to 15 parts of wild pepper, 15 to 20 parts of codonopsis pilosula, 8 to 12 parts of divaricate saposhnikovia root, 8 to 12 parts of schizonepeta, 50 to 60 parts of semen brassicae, 15 to 20 parts of Sichuan cassia twig, 10 to 15 parts of ephedra, 15 to 20 parts of liquorice, and 100 to 150 parts of ginger. The externally-applied medicine has the advantages that raw medicines are reasonably mixed and are easily obtained, the cost is low, the preparation method is simple and convenient, the recurrence is avoided, the treatment effect is obvious, no toxic and side effects are caused, and the shortages of clinical medicines for treating allergic rhinitis and asthma syndrome can be overcome.

Description

A kind of external used medicine for the treatment of of allergic rhinitis-Asthma Syndrome
Technical field
The present invention relates to a kind of external used medicine for the treatment of of allergic rhinitis-Asthma Syndrome, belong to technical field of Chinese medicines.
Background technology
Rhinitis, asthma are respiratory system commonly encountered diseases, difficult disease, along with environmental pollution increases the weight of, suffer from rhinitis, asthma patient increasing, especially with child and adolescent patient in the majority.Allergic rhinitis-Asthma Syndrome is the new medical diagnosis title proposed in recent years, refers to the allergic conditions (asthma) of simultaneous clinical or subclinical upper respiratory tract allergy (allergic rhinitis) and lower respiratory tract, and both often simultaneously and deposit.Clinical symptoms mainly contain rhinocnesmus, sneeze again and again, flow clear nasal mucus, nasal obstruction, cough and pant.In Allergic Rhinitis, the sickness rate of asthma then can up to 20-40%, and even someone thinks that 60% allergic rhinitis may develop into asthma or with lower respiratory tract symptom.The Therapy characteristics of allergic rhinitis-Asthma Syndrome is that treatment cycle is long, easy recurrent exerbation etc., drastically influence the physical and mental health of patient, especially child is in growth promoter period, long-term trouble allergic rhinitis-Asthma Syndrome can cause General Symptoms, as weak, be off one's feed, body weight does not increase, growth retardation, organ dysfunction, children ' s intelligence development obstacle etc., has a strong impact on the growth and development of child.
At present, doctor trained in Western medicine to the Therapeutic Method of allergic rhinitis-Asthma Syndrome mainly comprise per nasal suck carry out the treatment of upper and lower respiratory tract combination with glucocorticoids, antihistamine drug treatment, allergen vaccine treatment etc.; The traditional Chinese medical science mainly with oral expelling wind and cold class Chinese medicine for main method, other also use some such as three nine-day periods after the winter solstices to paste or the external plaster Drug therapy of Dog-day paste classes, but such medication effect is unsatisfactory, and clinical applicability is poor.In addition, therefore disease is chronic disease, and Chinese and western medicine is all very long for medicine time, and side effect is obvious, especially to child and adolescent patient, takes medicine for a long time and has a strong impact on its growth promoter.
Summary of the invention
For above-mentioned prior art, the invention provides a kind of external used medicine for the treatment of of allergic rhinitis-Asthma Syndrome.We's compatibility is reasonable, and medical material is easy to get, with low cost, and manufacture method is easy, does not recur more, determined curative effect and without any side effects, overcomes clinical treatment allergic rhinitis, asthma without the drawback of specific medicament.
The present invention is achieved by the following technical solutions:
A kind of external used medicine for the treatment of of allergic rhinitis-Asthma Syndrome, it is characterized in that, it is made up of the crude drug of following weight portion: Fructus Xanthii 10-20 part, Rhizoma Ligustici 10-14 part, Caulis Spatholobi 10-15 part, Herba Asari 10-20 part, Pericarpium Zanthoxyli 10-15 part, Radix Codonopsis 15-20 part, Radix Saposhnikoviae 8-12 part, Herba Schizonepetae 8-12 part, Semen Sinapis Albae 50-60 part, Ramulus Cinnamomi 15-20 part, Herba Ephedrae 10-15 part, Radix Glycyrrhizae 15-20 part, Rhizoma Zingiberis Recens 100-150 part.
Preferably, the external used medicine of described treatment of allergic rhinitis-Asthma Syndrome, it is characterized in that, it is made up of the crude drug of following weight portion: Fructus Xanthii 15 parts, Rhizoma Ligustici 12 parts, Caulis Spatholobi 13 parts, Herba Asari 15 parts, 14 parts, Pericarpium Zanthoxyli, Radix Codonopsis 17 parts, Radix Saposhnikoviae 10 parts, Herba Schizonepetae 10 parts, Semen Sinapis Albae 55 parts, Ramulus Cinnamomi 16 parts, 12 parts, Herba Ephedrae, 16 parts, Radix Glycyrrhizae, 130 parts, Rhizoma Zingiberis Recens.
Preparation method and the using method of medicine of the present invention are as follows:
Preparation method: take formula ratio Fructus Xanthii, Rhizoma Ligustici, Caulis Spatholobi, Herba Asari, Pericarpium Zanthoxyli, Radix Codonopsis, Radix Saposhnikoviae, Herba Schizonepetae, Semen Sinapis Albae, Ramulus Cinnamomi, Herba Ephedrae, Radix Glycyrrhizae, and pulverizing grinds to form fine powder respectively, for subsequent use after mix homogeneously; Formula ratio Rhizoma Zingiberis Recens is cleaned chopping to add in juicer, beats juice for subsequent use.
Using method: get mixed-powder 15 grams, adds appropriate Rhizoma Zingiberis Recens juice mixing furnishing pureed and is divided into 6 balls, being sticked on big vertebra, Jianjing, Tan Zhong, feishu acupuncture point by a ball with adhesive plaster.Each acupuncture point one is pasted, and sticks simultaneously, each application time 6-8 hour, and pasted once every 7 days, general manifold card can be cured for 3-5 time.
The pharmacological action of medicine of the present invention is as follows:
Fructus Xanthii: bitter in the mouth, sweet, pungent, warm in nature; Return lung, Liver Channel; There is dispersing wind-cold, clearing the nasal passage, wind-damp dispelling, effect of pain relieving.Rhizoma Ligustici: acrid in the mouth, warm in nature; Return urinary bladder channel; Expelling wind and cold, removing damp and stopping pain.Herba Asari: pungent, temperature; GUIXIN, lung, kidney channel; There is the cold expelling that induces sweat, wind-expelling pain-stopping, sensible, effect of warming the lung to resolve fluid-retention.Caulis Spatholobi: bitter, micro-sweet, temperature; Return Liver Channel;
There is blood circulation promoting and enriching, effect of relaxing muscles and tendons and activating QI and blood in the collateral.Pericarpium Zanthoxyli: acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel; There is warming spleen and stomach for dispelling cold, stomach invigorating dehumidifying, pain relieving parasite killing, effect of regulating the flow of vital energy of detoxifying.Radix Codonopsis: property is put down, sweet in the mouth; Return spleen, lung meridian; There is effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Return bladder, lung, spleen, Liver Channel; There is expelling pathogenic wind from the body surface, removing dampness to relieve pain, effect of relieving convulsion.Herba Schizonepetae: acrid in the mouth, slightly warm in nature; Return lung, Liver Channel; There is the loose wind that induces sweat, rash, the effect of the skin ulcer that disappears.Semen Sinapis Albae: warm in nature, acrid in the mouth, peppery; Return lung meridian; There is warming the lung to eliminate phlegm, promoting the circulation of QI eliminating stagnation, effect of removing obstruction in the collateral to relieve pain.Ramulus Cinnamomi: acrid, sweet, warm; GUIXIN, lung, urinary bladder channel; There is relieving the exterior syndrome by diaphoresis, promoting the flow of QI-blood by warming the meridian, effect of activating YANG and prormoting functioning of QI.Herba Ephedrae: acrid in the mouth, micro-hardship, warm in nature; Return lung, bladder two warp; There is diaphoresis cold expelling, depressed lung-energy dispersing, effect of inducing diuresis to remove edema.Radix Glycyrrhizae: sweet in the mouth, gas is put down, and property is delayed; Enter spleen, stomach warp; Have and middle emergency, lung moistening, removing toxic substances, effect of coordinating the actions of various ingredients in a prescription.
The invention has the beneficial effects as follows: compatibility of drugs of the present invention is reasonable, raw material is easy to get, with low cost, manufacture method is simple, and clinical practice is convenient, determined curative effect and without any side effects, more do not recur after, without the need to prolonged administration of drugs, there is tonifying the lung spleen invigorating, QI invigorating dispeled the wind, dissipating phlegm and resolving masses, relieving cough and asthma, heat-clearing and toxic substances removing effect, be the good recipe for the treatment of of allergic rhinitis-Asthma Syndrome.
Detailed description of the invention
Below in conjunction with specific embodiment, content of the present invention is described in further detail.
Embodiment 1
The medicine of the present embodiment is made up of the crude drug of following weight: Fructus Xanthii 10g, Rhizoma Ligustici g, Caulis Spatholobi 10g, Herba Asari 10g, Pericarpium Zanthoxyli 10g, Radix Codonopsis 15g, Radix Saposhnikoviae 8g, Herba Schizonepetae 8g, Semen Sinapis Albae 50g, Ramulus Cinnamomi 15g, Herba Ephedrae 10g, Radix Glycyrrhizae 15g, Rhizoma Zingiberis Recens 100g.
The preparation method of said medicine is: take formula ratio Fructus Xanthii, Rhizoma Ligustici, Caulis Spatholobi, Herba Asari, Pericarpium Zanthoxyli, Radix Codonopsis, Radix Saposhnikoviae, Herba Schizonepetae, Semen Sinapis Albae, Ramulus Cinnamomi, Herba Ephedrae, Radix Glycyrrhizae, and pulverizing grinds to form fine powder respectively, for subsequent use after mix homogeneously; Formula ratio Rhizoma Zingiberis Recens is cleaned chopping to add in juicer, beats juice for subsequent use.
The using method of medicine of the present invention is: get mixed-powder 15 grams, adds appropriate Rhizoma Zingiberis Recens juice mixing furnishing pureed and is divided into 6 balls, being sticked on big vertebra, Jianjing, Tan Zhong, feishu acupuncture point by a ball with adhesive plaster.Each acupuncture point one is pasted, and sticks simultaneously, each application time 6-8 hour, pastes once every 7 days.
Embodiment 2
The medicine of the present embodiment is made up of the crude drug of following weight: Fructus Xanthii 20g, Rhizoma Ligustici 14g, Caulis Spatholobi 15g, Herba Asari 20g, Pericarpium Zanthoxyli 15g, Radix Codonopsis 20g, Radix Saposhnikoviae 12g, Herba Schizonepetae 12g, Semen Sinapis Albae 60g, Ramulus Cinnamomi 20g, Herba Ephedrae 15g, Radix Glycyrrhizae 20g, Rhizoma Zingiberis Recens 150g.
The preparation method of said medicine and using method are with embodiment 1.
Embodiment 3
The medicine of the present embodiment is made up of the crude drug of following weight: Fructus Xanthii 15g, Rhizoma Ligustici 12g, Caulis Spatholobi 13g, Herba Asari 15g, Pericarpium Zanthoxyli 14g, Radix Codonopsis 17g, Radix Saposhnikoviae 10g, Herba Schizonepetae 10g, Semen Sinapis Albae 55g, Ramulus Cinnamomi 16g, Herba Ephedrae 12g, Radix Glycyrrhizae 16g, Rhizoma Zingiberis Recens 130g.
The preparation method of said medicine and using method are with embodiment 1.
Clinical practice example
1. clinical data: select outpatient service accept allergic rhinitis-Asthma Syndrome patient 140 people for medical treatment, wherein man 65 example, female 75 example, the age 10-60 year, course of disease 3-10.Be divided into matched group and each 70 examples for the treatment of group at random, two groups of patients are at all no difference of science of statistics such as age, the course of disease, clinical manifestation.
2. diagnostic criteria: the relevant criterion in the allergic rhinitis diagnosis and treatment standard formulated in calendar year 2001 with reference to WHO and 08 edition " global asthma is prevented and treated and proposed " (GINA).
3. Therapeutic Method:
Treatment group: get mixed-powder 15 grams prepared by the embodiment of the present invention 3 during every patient treatment, add appropriate Rhizoma Zingiberis Recens juice mixing furnishing pureed and be divided into 6 balls, with adhesive plaster, a ball being sticked on big vertebra, Jianjing, Tan Zhong, feishu acupuncture point.Each acupuncture point one is pasted, and sticks simultaneously, each application time 6-8 hour, and pasted once every 7 days, general manifold card can be cured for 3-5 time; Three nine-day periods after the winter solstice that matched group patient adopts conventional formulation obtained pastes application treatment, and the acupuncture point of subsides is big vertebra, fei shu, cream Yu, Tan Zhong, Guan Yuan, often pastes 4-6 hour, pastes once every 7 days.Two groups for the treatment of cycle are 30 days.
4. curative effect determinate standard:
Cure: symptom and sign all disappear, follow up a case by regular visits to more than 1 year without recurrence;
Effective: symptom, sign have before comparatively treating and obviously alleviate;
Invalid: before and after treatment, symptom and sign is without significant change.
5. therapeutic outcome: the results are shown in Table 1.
Table 1 clinical treatment outcome
Case load Cure Effectively Invalid Total effective rate (%)
Treatment group 70 56 13 1 98.6
Matched group 70 48 17 5 92.9
Result as can be seen from table 1, treatment group total effective rate is better than matched group, the more existing medicine better efficacy of medicine of visible treatment of allergic rhinitis-Asthma Syndrome provided by the present invention, and its cure rate is 80%, improvement rate is 18.6%, and total effective rate can reach 98.6%.
6. model case
Case 1: Wang, man, 15 years old, in July, 2012 goes to a doctor in here, has told sneeze repeatedly, snivel, rubs nose and the symptom such as to rub one's eyes with the hands, after occur again panting, the symptom such as cough, bringing to the study of patient and have a strong impact on, is allergic rhinitis Asthma Syndrome after diagnosing.Stick after being introduced medicine of the present invention once after symptom obviously alleviate, after use twice continuously again, symptom all disappears, and follows up a case by regular visits in 2 years and does not recur.
Case 2: Cai so-and-so, female, 46 years old, in December, 2010 came here and goes to a doctor, and told calendar year 2001 to transfer allergic rhinitis to because of flu, after meeting cold air, symptom is more obvious, play sneeze morning repeatedly, nasal obstruction, watery nasal discharge are serious, once flu suppresses without long-acting hormone, substantially can not get well, the time has grown rear concurrent symptoms of asthma.Told rhinocnesmus, sneeze again and again, flow clear nasal mucus, nasal obstruction, cough and the symptom such as to pant, be diagnosed as allergic rhinitis Asthma Syndrome.After stick medicine of the present invention 4 times after, symptom all disappears, and follows up a case by regular visits to and does not recur more than a year.
Case 3: Lin, female, 28 years old, in October, 2013 went to a doctor in here, and patient suffers from allergic rhinitis more than 4 years, repeatedly nasal obstruction, rhinorrhea.Madly must sneeze battle array every morning to do, after voluntarily medication to fail to respond to any medical treatment fruit, recurrent exerbation, after 2 years, is still nasal mucus as clear water, severe nasal blockage, with headache, and after this starts to have slight asthma to occur, is often in flu state.After sticking medicine of the present invention 1 time, symptom obviously alleviates, and rear continuation use 2 times, patients symptomatic disappears entirely, follows up a case by regular visits to and does not recur so far.
Case 4: Liu, man, 58 years old, in JIUYUE, 2010 was come here and is gone to a doctor, and tells to suffer from and does not effect a radical cure in more than 10 years of allergic rhinitis, but in the recent period again along with the appearance of asthma, left uncomfortable in chest, there is song again, rhinitis, nasal obstruction, also constantly rhinorrhea, sneeze, also drops tears time serious, irritable cough.After sticking medicine of the present invention 2 times, transference cure is more than half, after continue again use 3 times, patients symptomatic all disappears, and follows up a case by regular visits to and does not recur for 3 years.

Claims (2)

1. the external used medicine for the treatment of of allergic rhinitis-Asthma Syndrome, it is characterized in that, it is made up of the crude drug of following weight portion: Fructus Xanthii 10-20 part, Rhizoma Ligustici 10-14 part, Caulis Spatholobi 10-15 part, Herba Asari 10-20 part, Pericarpium Zanthoxyli 10-15 part, Radix Codonopsis 15-20 part, Radix Saposhnikoviae 8-12 part, Herba Schizonepetae 8-12 part, Semen Sinapis Albae 50-60 part, Ramulus Cinnamomi 15-20 part, Herba Ephedrae 10-15 part, Radix Glycyrrhizae 15-20 part, Rhizoma Zingiberis Recens 100-150 part.
2. the external used medicine for the treatment of of allergic rhinitis-Asthma Syndrome according to claim 1, it is characterized in that, it is made up of the crude drug of following weight portion: Fructus Xanthii 15 parts, Rhizoma Ligustici 12 parts, Caulis Spatholobi 13 parts, Herba Asari 15 parts, 14 parts, Pericarpium Zanthoxyli, Radix Codonopsis 17 parts, Radix Saposhnikoviae 10 parts, Herba Schizonepetae 10 parts, Semen Sinapis Albae 55 parts, Ramulus Cinnamomi 16 parts, 12 parts, Herba Ephedrae, 16 parts, Radix Glycyrrhizae, 130 parts, Rhizoma Zingiberis Recens.
CN201510003229.5A 2015-01-06 2015-01-06 Externally-applied medicine for treating combined allergic rhinitis and asthma syndrome Pending CN104548024A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105664090A (en) * 2016-01-20 2016-06-15 赵世明 Traditional Chinese medicine combination for treating allergic rhinitis
CN110917271A (en) * 2019-11-25 2020-03-27 垒途智能教科技术研究院江苏有限公司 Spray for preventing and treating allergic asthma combined allergic rhinitis of children and teenagers

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CN110917271A (en) * 2019-11-25 2020-03-27 垒途智能教科技术研究院江苏有限公司 Spray for preventing and treating allergic asthma combined allergic rhinitis of children and teenagers

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