CN103638234A - Traditional Chinese medicine composition for treating tinnitus, preparation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating tinnitus, preparation and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines and relates to a traditional Chinese medicine composition for treating tinnitus, a preparation and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients in parts by weight: 8-15 parts of grassleaf sweelflag rhizome, 8-15 parts of Szechuan lovage rhizome, 20-30 parts of membranous milkvetch root, 10-15 parts of pilose asiabell root, 15-30 parts of radix salviae miltiorrhizae, 10-20 parts of red paeony root, 10-20 parts of kudzuvine root, 10-15 parts of towel gourd vegetable sponge and 6-10 parts of beautiful sweetgum fruit. The traditional Chinese medicine composition provided by the invention can be prepared into any common oral preparation according to a conventional traditional Chinese medicine preparation method. The composition provided by the invention has precise and appropriate compatibility and has the functions of activating blood circulation, inducing resuscitation, benefiting qi and invigorating the kidneys, and clinical trials prove that the composition is very effective to treat patients with tinnitus, can rapidly improve symptoms and cure most of the patients, has no toxic or side effects and is suitable for treating tinnitus caused by various reasons.
Description
Technical field:
The present invention relates to technical field of Chinese medicines, particularly a kind of Chinese medicine composition for the treatment of tinnitus, preparation and preparation method thereof.
Background technology:
Tinnitus is a kind of symptom of auditory abnormality, and take conscious in ear ring or intracranial ring is main manifestations, simultaneously extraneous normal without corresponding sound source or electricity irritation.At present not yet completely clear for the etiology and pathogenesis of tinnitus, many general diseases and ear disease all can cause tinnitus.Tinnitus can be of short duration or persistence exist, that tinnitus is followed is vexed, anxiety is even depressed etc., and normal patient's physiology and the psychology of giving causes very big puzzlement, clinical onset rate has the trend of continuous rising in recent years.
Existing medical science lacks effectively diagnosis and treatment means to tinnitus, and some,, for clinical a certain symptom treatment, often falls flat, and the effect of various Chinese and western drugs treatment tinnitus is not satisfied.
Summary of the invention:
The object of this invention is to provide a kind of Chinese medicine composition and compound preparation for the treatment of tinnitus, adopt this compound Chinese medicinal preparation, be used for the treatment of clinically common tinnitus symptom, fundamentally treat tinnitus, reach double the effecting a permanent cure of taking stopgap measures, and possess the advantage that curative effect is high, cost is low, toxic and side effects is minimum.
Another object of the present invention is to provide the preparation method of medicine composite preparation in a kind of above-mentioned treatment tinnitus.
The present invention selects Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Puerariae, and Retinervus Luffae Fructus, Fructus Liquidambaris nine taste crude drug combinations, opening the orifice and activating blood circulation, vital energy benefiting and the kidney invigorating, can effectively treat tinnitus.
The present invention adds Rhizoma Wenyujin Concisum, Cortex Phellodendri, Semen Cuscutae, Fructus Rubi, Fructus Lycii on the basis of above-mentioned nine taste crude drug compositionss again, and the crude drug such as Rhizoma Cimicifugae, Radix Glycyrrhizae are assisted a ruler in governing a country, Bushen Tongluo, tying-in coordinating the actions of various ingredients in a prescription, and the effect that makes to treat tinnitus is more obvious.
The brief introduction of above-mentioned raw materials medicine medical material effect is as follows:
Rhizoma Acori Graminei: acrid in the mouth, hardship, temperature.Be included into the heart, stomach, liver three warps.Have that expectorant is had one's ideas straightened out, hearing-improing and eyesight improving, removing dampness to restore normal function of the stomach, cold expelling eliminating impediment, the effect such as antipruritic of drying.Cure mainly mental confusion due to phlegm, forgetful, the vexed pain of gastral cavilty distension, cold numbness general pain, polyhidrosis around the external genitals pruritus due to damp pathogen etc.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, heart channel.There is blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.[pharmacopeia essence want] < < Compendium of Materia Medica > > records: Rhizoma Chuanxiong can dampness, antidiarrheal dysentery, activating QI to alleviate the depression.Cure mainly menoxenia, amenorrhea dysmenorrhea, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Astragali: sweet in the mouth, warm in nature.Return lung, spleen, liver, kidney channel.There are the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.Cure mainly the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Radix Codonopsis: sweet in the mouth, property is flat.Return lung, spleen channel.There is invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Cure mainly deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.Classify the heart, Liver Channel.There is promoting blood circulation to remove obstruction in the collateral, removing heat from blood detumescence, the function that relieving restlessness clears away heart-fire.Cure mainly dysmenorrhea, amenorrhea, abdominal mass, the blood stasis carbuncle sore tumefacting virus of having a pain, dysphoria with smothery sensation is uneasy.
Radix Paeoniae Rubra: sour in the mouth is bitter, cold nature.Return Liver Channel.Have and let out clearly liver-fire, removing blood stasis and activating blood flow, the function of pain relieving.Cure mainly menoxenia, the stagnant stomachache of the stasis of blood, amenorrhea note of the ancient Chinese abdominal mass, carbuncle sore tumefacting virus, arthralgia, pain in chest and hypochondrium.
Radix Puerariae: sweet in the mouth, pungent, property are flat.Return spleen, stomach warp.Deliver and bring down a fever, the function of promoting the production of body fluid to quench thirst." treat flesh induces sweat Radix Puerariae first and Radix Bupleuri takes second place ", sees < < Yaoxing Fu > >.Cure mainly: table disease fever without perspiration, rigidity pain on the head and nape, calentura is thirsty, quenches one's thirst, and macule is not saturating, diarrhea due to hypofunction of the spleen.
Retinervus Luffae Fructus: sweet in the mouth, property is flat.Return lung, stomach, Liver Channel.The effect that has heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, inducing diuresis to remove edema.Cure mainly muscles and bones aching, chest and hypochondrium, galactostasis, amenorrhea, painful and swollen testis, have blood in stool, the disease such as metrorrhagia.
Fructus Liquidambaris: bitter in the mouth, property is flat.Return liver, stomach warp.There are promoting the circulation of QI to relieve pain, the effect of promoting blood circulation to remove obstruction in the collateral, inducing diuresis to remove edema.Cure mainly limbs arthralgia pain, stomachache, rheumatic arthralgia, edema, distension, carbuncle, scabies eczema.
Rhizoma Wenyujin Concisum: bitter in the mouth, pungent, warm in nature.Return spleen, Liver Channel.The effect that has blood-activating and qi-promoting pain relieving, wind-damp dispelling profit arthralgia pain.Cure mainly amenorrhea lump in the abdomen, the twinge of the breast side of body, the traumatic injury of stagnation of QI and blood; The shoulder and back ache of anemofrigid-damp arthralgia, qi depression to blood stasis, blockage of main and collateral channels.
Cortex Phellodendri: bitter in the mouth, cold in nature.Return kidney, urinary bladder channel.There is the effect of rushing down kidney fire, clearing away damp-heat, solution sore.Cure mainly hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, jaundice, urine retention, stranguria with turbid discharge, leukorrhagia.The diseases such as foot swelling and pain in knee, carbuncle skin infection.
Semen Cuscutae: sweet in the mouth, warm in nature.Return spleen, liver, kidney channel.There is tonifying liver spleen kidney, controlling nocturnal emission with astringent drugs reducing urination, the effect of improving eyesight antidiarrheal.Cure mainly soreness of waist and knee joint, spermatorrhea, incontinence of urine, poor vision, spleen is suffered from a deficiency of the kidney and the disease such as is rushed down.
Fructus Rubi: sweet in the mouth, acid, warm in nature.Return liver, kidney channel.There is tonifying the kidney to consolidate the essence, the effect of supporing yang improving eyesight.Cure mainly sexual impotence, the seminal emission enuresis, frequent micturition, the dim-sighted grade of eyes disease.
Fructus Lycii: sweet in the mouth, property are put down.Return liver, lung, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening, lung moistening, the effect of improving eyesight.Cure mainly gallbladder insufficiency of kidney-YANG, soreness of the waist and knees, cough due to consumptive disease, the vertigo, keratoconjunctivitis, the disease such as quench one's thirst.
Rhizoma Cimicifugae: sweet in the mouth, pungent, cold nature.Return lung, spleen, stomach warp.Have deliver, the effect of yang invigorating, rash removing toxic substances.Cure mainly headache due to pathogenic wind-heat, sinking of QI of middle-JIAO, macule such as does not go out at the disease.
Radix Glycyrrhizae: sweet in the mouth, property are put down.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong etc.
It is monarch drug that the compound Chinese medicinal preparation that the present invention treats tinnitus be take Rhizoma Acori Graminei, Rhizoma Chuanxiong opening the orifice and activating blood circulation, the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Puerariae benefiting QI for activating blood circulation are ministerial drug, Retinervus Luffae Fructus, Fructus Liquidambaris, Rhizoma Wenyujin Concisum, Cortex Phellodendri, Semen Cuscutae, Fructus Rubi, Fructus Lycii Bushen Tongluo are adjuvant drug, Rhizoma Cimicifugae, Radix Glycyrrhizae tying-in coordinating the actions of various ingredients in a prescription are for making medicine, and compatibility is precise and appropriate, has opening the orifice and activating blood circulation, the function of vital energy benefiting and the kidney invigorating, be used for the treatment of tinnitus, curative effect is reliable, significantly.
Concrete technical scheme of the present invention is:
The invention provides a kind of Chinese medicine composition for the treatment of tinnitus, comprise the crude drug of following weight portion proportioning:
8～15 parts of Rhizoma Acori Graminei, 8～15 parts of Rhizoma Chuanxiongs, 20～30 parts of the Radixs Astragali, 10～15 parts of Radix Codonopsis, 15～30 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Radix Puerariaes, 10～15 parts of Retinervus Luffae Fructuss, 6～10 parts of Fructus Liquidambaris.
Chinese medicine composition of the present invention, the crude drug of preferred following weight portion proportioning:
10 parts of Rhizoma Acori Graminei, 10 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Paeoniae Rubra, 15 parts of Radix Puerariaes, 10 parts of Retinervus Luffae Fructuss, 6 parts of Fructus Liquidambaris.
The present invention also provides a kind of Chinese medicine composition for the treatment of tinnitus, and it is to be made by the crude drug of following weight portion proportioning:
8～15 parts of Rhizoma Acori Graminei, 8～15 parts of Rhizoma Chuanxiongs, 20～30 parts of the Radixs Astragali, 10～15 parts of Radix Codonopsis, 15～30 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Radix Puerariaes, 10～15 parts of Retinervus Luffae Fructuss, 6～10 parts of Fructus Liquidambaris; 8～12 parts of Rhizoma Wenyujin Concisum, 8～12 parts of Cortex Phellodendris, 10～20 parts of Semen Cuscutae, 10～20 parts of Fructus Rubies, 10～15 parts of Fructus Lycii, 6～10 parts of Rhizoma Cimicifugaes, 6～10 parts, Radix Glycyrrhizae.
Above-mentioned Chinese medicine composition, the crude drug of preferred following weight portion proportioning:
10 parts of Rhizoma Acori Graminei, 10 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Paeoniae Rubra, 15 parts of Radix Puerariaes, 10 parts of Retinervus Luffae Fructuss, 6 parts of Fructus Liquidambaris, 10 parts of Rhizoma Wenyujin Concisum, 10 parts of Cortex Phellodendris, 15 parts of Semen Cuscutae, 15 parts of Fructus Rubies, 15 parts of Fructus Lycii, 6 parts of Rhizoma Cimicifugaes, 6 parts, Radix Glycyrrhizae.
The present invention also provides a kind of Chinese medicine extract for the treatment of tinnitus, and described extract is prepared through conventional Traditional Chinese medicine extraction method by above-mentioned any one Chinese medicine composition.
The purposes of described Chinese medicine extract in the compound Chinese medicinal preparation of preparation treatment tinnitus.
The present invention also provides a kind of compound Chinese medicinal preparation for the treatment of tinnitus, and described preparation is to be made by acceptable adjuvant on above-mentioned any one Chinese medicine composition and pharmaceutics.
Preparation of the present invention is preferably oral formulations.Described oral formulations can be decoction, pill, powder, granule, tablet, capsule, soft extract, drop pill, syrup or oral liquid.According to the difference of route of administration, the present composition also can be made into general external preparation, as unguentum etc.But be not limited to above-mentioned dosage form, can, according to the method that in field of traditional Chinese, oneself knows, after aforementioned pharmaceutical compositions is extracted by own perception method, according to clinical, need to make various different dosage forms.
The present invention also provides a kind of method of preparing the Chinese medicine composition of above-mentioned treatment tinnitus,
Comprise the following steps:
(1) choose any one crude drug in above-mentioned composition, clean, mix by weight ratio,
(2) crude drug is soaked to 30-40 minute according to a conventional method; The water yield was soaked powder;
(3) add medical material gross weight 6-10 decocting doubly and boil 3 times, each 30-50 minute;
(4) merge 3 decoction liquor, filter, and to be condensed into relative density be 1.15-1.35k
g/ m
3fluid extract;
Adopt conventional preparation technology, can be prepared into said dosage form on any pharmaceutics, as capsule, powder, oral liquid, granule, pill, soft extract.
Chinese medicine composition of the present invention can also be for the preparation for the treatment of in the medicine of tinnitus.
The present invention's herbal raw material medicine used all can be buied from Chinese medicine shop, and its specification meets national medical standard.Usage and dosage: dosage of the present invention depends on concrete dosage form, the factors such as patient age, body weight, health status.
Beneficial effect of the present invention:
Chinese medicine composition compatibility of the present invention is precise and appropriate, there is opening the orifice and activating blood circulation, the function of vital energy benefiting and the kidney invigorating, through clinical trial, confirm, very effective for the treatment of tinnitus patient, can make symptom improve rapidly, majority can obtain healing, have no side effect, be applicable to the tinnitus that a variety of causes causes, there is good prospect of the application and market prospect.
The specific embodiment:
Embodiment of the present invention medical material used, all purchased from Chinese Medicinal Materials Co, meets Pharmacopoeia of People's Republic of China standard.
Embodiment 1: the preparation of granule
According to following weight parts proportioning, take each crude drug:
Rhizoma Acori Graminei 8g, Rhizoma Chuanxiong 8g, Radix Astragali 25g, Radix Codonopsis 12g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 10g, Radix Puerariae 20g, Retinervus Luffae Fructus 15g, Fructus Liquidambaris 8g;
Clean, mix by weight ratio, crude drug is soaked 40 minutes according to a conventional method; The water yield was soaked powder; The decocting that adds 6 times of medical material gross weights boils 3 times, each 30 minutes; Merge 3 times decoction liquor, filter, and to be condensed into relative density be 1.15kg/m
3fluid extract; According to the preparation method of conventional granulates agent, concentrated fluid extract is dried, is ground into 100～120 object medicated powder, spray granulation, dry, subpackage.
Embodiment 2: the preparation of granule
According to following weight parts proportioning, take each crude drug:
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g;
Clean, mix by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The water yield was soaked powder; The decocting that adds 8 times of medical material gross weights boils 3 times, each 40 minutes; Merge 3 times decoction liquor, filter, and to be condensed into relative density be 1.20kg/m
3fluid extract; According to the preparation method of conventional granulates agent, concentrated fluid extract is dried, is ground into 100～120 object medicated powder, spray granulation, dry, subpackage.
Embodiment 3: the preparation of granule
According to following weight parts proportioning, take each crude drug:
Rhizoma Acori Graminei 15g, Rhizoma Chuanxiong 15g, Radix Astragali 20g, Radix Codonopsis 10g, Radix Salviae Miltiorrhizae 30g, Radix Paeoniae Rubra 20g, Radix Puerariae 10g, Retinervus Luffae Fructus 12g, Fructus Liquidambaris 10g.
Each crude drug is cleaned, mixed by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The water yield was soaked powder; The decocting that adds 10 times of medical material gross weights boils 3 times, each 50 minutes; Merge 3 times decoction liquor, filter, and to be condensed into relative density be 1.3kg/m
3fluid extract; According to the preparation method of conventional granulates agent, concentrated fluid extract is dried, is ground into 100～120 object medicated powder, spray granulation, dry, subpackage.
The preparation of embodiment 4 granules
According to following proportioning, take each crude drug,
Rhizoma Acori Graminei 8g, Rhizoma Chuanxiong 8g, Radix Astragali 25g, Radix Codonopsis 12g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 10g, Radix Puerariae 20g, Retinervus Luffae Fructus 15g, Fructus Liquidambaris 8g, Rhizoma Wenyujin Concisum 12g, Cortex Phellodendri 8g, Semen Cuscutae 20g, Fructus Rubi 10g, Fructus Lycii 12g, Rhizoma Cimicifugae 8g, Radix Glycyrrhizae 10g.
Each crude drug is cleaned, mixed by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The water yield was soaked powder; The decocting that adds 6 times of medical material gross weights boils 3 times, each 30 minutes; Merge 3 times decoction liquor, filter, and to be condensed into relative density be 1.15kg/m
3thick paste; According to the preparation method of conventional granulates agent, concentrated fluid extract is dried, is ground into 100～120 object medicated powder, spray granulation, dry, subpackage.
The preparation of embodiment 5 granules
According to following proportioning, take each crude drug, standby;
Rhizoma Acori Graminei 15g, Rhizoma Chuanxiong 15g, Radix Astragali 20g, Radix Codonopsis 10g, Radix Salviae Miltiorrhizae 30g, Radix Paeoniae Rubra 20g, Radix Puerariae 10g, Retinervus Luffae Fructus 12g, Fructus Liquidambaris 10g, Rhizoma Wenyujin Concisum 8g, Cortex Phellodendri 12g, Semen Cuscutae 10g, Fructus Rubi 20g, Fructus Lycii 10g, Rhizoma Cimicifugae 10g, Radix Glycyrrhizae 8g.
Each crude drug is cleaned, mixed by weight ratio, crude drug is soaked 40 minutes according to a conventional method; The water yield was soaked powder; The decocting that adds 8 times of medical material gross weights boils 3 times, each 40 minutes; Merge 3 times decoction liquor, filter, and to be condensed into relative density be 1.2kg/m
3thick paste; According to the preparation method of conventional granulates agent, concentrated fluid extract is dried, is ground into 100～120 object medicated powder, spray granulation, dry, subpackage.
The preparation of embodiment 6 granules
According to following proportioning, take each crude drug, standby;
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g, Rhizoma Wenyujin Concisum 10g, Cortex Phellodendri 10g, Semen Cuscutae 15g, Fructus Rubi 15g, Fructus Lycii 15g, Rhizoma Cimicifugae 6g, Radix Glycyrrhizae 6g.
Each crude drug is cleaned, mixed by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The water yield was soaked powder; The decocting that adds 10 times of medical material gross weights boils 3 times, each 50 minutes; Merge 3 times decoction liquor, filter, and to be condensed into relative density be 1.3kg/m
3fluid extract; According to the preparation method of conventional granulates agent, concentrated fluid extract is dried, is ground into 100～120 object medicated powder, spray granulation, dry, subpackage.
The preparation of embodiment 7 capsules
According to following proportioning, take each crude drug, standby;
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g, Rhizoma Wenyujin Concisum 10g, Cortex Phellodendri 10g, Semen Cuscutae 15g, Fructus Rubi 15g, Fructus Lycii 15g, Rhizoma Cimicifugae 6g, Radix Glycyrrhizae 6g.
Each crude drug is cleaned, mixed by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The water yield was soaked powder; The decocting that adds 10 times of medical material gross weights boils 3 times, each 50 minutes; Merge 3 times decoction liquor, filter, and to be condensed into relative density be 1.15kg/m
3thick paste;
According to the operational approach of conventional capsule,, the fluid extract of the mix homogeneously making is concentrated, add pharmaceutic adjuvant, by component mix homogeneously, granulate, adopt conventional capsule preparation method to fill and make capsule.
The preparation of embodiment 8 oral liquids
According to following proportioning, take each crude drug, standby;
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g, Rhizoma Wenyujin Concisum 10g, Cortex Phellodendri 10g, Semen Cuscutae 15g, Fructus Rubi 15g, Fructus Lycii 15g, Rhizoma Cimicifugae 6g, Radix Glycyrrhizae 6g.
Each crude drug is cleaned, mixed by weight ratio, crude drug is soaked 40 minutes according to a conventional method; The water yield was soaked powder; The decocting that adds 10 times of medical material gross weights boils 3 times, each 50 minutes; Merge 3 times decoction liquor, filter, and to be condensed into relative density be 1.35kg/m
3fluid extract;
According to the preparation method of conventional oral liquid, the fluid extract of mix homogeneously is concentrated, and ethanol precipitation 1-2 time, filters, concentrated, and aqueous precipitation filters subpackage sterilizing; After check, packed products, makes oral liquid.
The preparation of embodiment 9 decoctions
According to following proportioning, take each crude drug, standby;
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g, Rhizoma Wenyujin Concisum 10g, Cortex Phellodendri 10g, Semen Cuscutae 15g, Fructus Rubi 15g, Fructus Lycii 15g, Rhizoma Cimicifugae 6g, Radix Glycyrrhizae 6g.
Each crude drug is cleaned, mixed by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The water yield was soaked powder 2～3cm and was advisable, and decocted with water 3 times, boiled with high heat to use slow fire instead again and decoct 30～40 minutes, merged 3 times decoction liquor, filtered medicinal residues and took concoction and get final product.
The present invention treats tinnitus clinical trial and interpretation of result
1 data and method
1.1 object of study
Object of study is selected from the tinnitus patient that PLA General Hospital was accepted for medical treatment year August in August, 2007 to 2013, totally 160 examples, female patient 72 examples wherein, male's 88 examples; Age be 25-67 year not etc., average (43.4 ± 7.8) year.160 routine patients are divided into matched group and experimental group at random, every group of 80 examples, two groups of patients without significant significant difference (P>0.05), have comparability at aspects such as sex, age and coincident with severity degree of conditions.
1.2 Tinnitus volume classifications
0 grade: without tinnitus; 1 grade: Tinnitus volume is minimum, seemingly have like nothing; 2 grades: Tinnitus volume is slight, but certainly can listen and obtain; 3 grades: moderate amplitude, has minimal effect to work and life; 4 grades: tinnitus is louder, take sb's mind off sth, affect Working Life; 5 grades: tinnitus is very loud, severe jamming life and work and rest; 6 grades: tinnitus is extremely loud, endurable.
1.3 screening criteria
Inclusive criteria: 1. two groups of patients all meet the diagnostic criteria of tinnitus in < < ear,nose & throat therapeutics > > and < < Otorhinolaryngology of TCM > >; 2. Tinnitus volume all should be greater than II level; 3. this research of voluntary participation, and sign Informed Consent Form.
Exclusion standard: 1. by tinnitus person due to wound, tumor and systemic disease; 2. the tinnitus person that acute and chronic otitis media and Nervous and Mental Factors etc. cause; 3. gestation or women breast-feeding their children; 4. be associated with the tinnitus patient of severe cardiac cerebrovascular disease, liver, kidney and disease of hematopoietic system; 5. the patient who participates in other clinical trial in nearly 3 months.
1.4 method
1. matched group: this group patient gives the flunarizine hydrochloride capsule 5mg that tremnbles, clothes before sleeping after meal, every day 1 time.Vitamin B12 once a day, an intramuscular injection 0.5mg;
2. experimental group: medicine composite preparation decoction (water decoction) in every group of oral the present invention of patient, every day potion, 1 dose of 200ml, minute 2 to 3 decoction being taken warmly.Within 14 days, be a course for the treatment of, totally 2 courses for the treatment of, treatment finishes rear observe the curative effect.
1.5 criterion of therapeutical effect
Parameters for observation on effect is treated tinnitus guideline of clinical investigations > > with reference to < < new Chinese medicine: 1. effective: tinnitus symptom disappears completely or only under night and quiet environment, occurs once in a while, audition returns to state or the obvious dysaudia of nothing while not falling ill substantially, maintains two weeks and does not recur above; 2. effective: tinnitus symptom is slightly alleviated, outbreak is only transferred to and under noisy environment, being occurred under quiet environment or only by persistence; 3. invalid: tinnitus and situation and take medicine before without obviously changing, also without changing, even there is deterioration in sign.Total effective rate=1.+2..
1.6 statistical procedures
This research adopts SPSS17.0 statistics software, adopts X 2 test, and P<0.05 is that difference has statistical significance.
2 results
2.1 efficacy result
After the treatment of 3 courses for the treatment of, effective 15 examples of matched group patient, effective 36 examples, invalid 29 examples, total effective rate 63.8%; Effective 28 examples of experimental group patient, effective 37 examples, invalid 15 examples, total effective rate 81.3%.The total effective rate of experimental group (81.3%) and obvious effective rate (35.0%) are apparently higher than total effective rate (63.8%) and the obvious effective rate (18.8%) of matched group, and the inefficiency (18.8%) that difference all has statistical significance (P<0.05) experimental group is starkly lower than matched group (36.3%), and its difference also has significant statistical significance (P<0.05).In Table 1.
Comparison of therapeutic after two groups of patient treatments of table l
Note: * represents relatively have significant significant difference, P<0.05 with matched group
Result shows, compound Chinese medicinal preparation of the present invention has significant curative effect to treatment tinnitus patient.
Claims (10)
1. a Chinese medicine composition for the treatment of tinnitus, is characterized in that, it is to be made by the crude drug of following weight portion proportioning:
8～15 parts of Rhizoma Acori Graminei, 8～15 parts of Rhizoma Chuanxiongs, 20～30 parts of the Radixs Astragali, 10～15 parts of Radix Codonopsis, 15～30 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Radix Puerariaes, 10～15 parts of Retinervus Luffae Fructuss, 6～10 parts of Fructus Liquidambaris.
2. Chinese medicine composition according to claim 1, is characterized in that, it is to be made by the crude drug of following weight portion proportioning:
10 parts of Rhizoma Acori Graminei, 10 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Paeoniae Rubra, 15 parts of Radix Puerariaes, 10 parts of Retinervus Luffae Fructuss, 6 parts of Fructus Liquidambaris.
3. a Chinese medicine composition for the treatment of tinnitus, is characterized in that, it is to be made by the crude drug of following weight portion proportioning:
8～15 parts of Rhizoma Acori Graminei, 8～15 parts of Rhizoma Chuanxiongs, 20～30 parts of the Radixs Astragali, 10～15 parts of Radix Codonopsis, 15～30 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Radix Puerariaes, 10～15 parts of Retinervus Luffae Fructuss, 6～10 parts of Fructus Liquidambaris; 8～12 parts of Rhizoma Wenyujin Concisum, 8～12 parts of Cortex Phellodendris, 10～20 parts of Semen Cuscutae, 10～20 parts of Fructus Rubies, 10～15 parts of Fructus Lycii, 6～10 parts of Rhizoma Cimicifugaes, 6～10 parts, Radix Glycyrrhizae.
4. treat according to claim 3 the Chinese medicine composition of tinnitus, it is characterized in that, it is to be made by the crude drug of following weight portion proportioning:
10 parts of Rhizoma Acori Graminei, 10 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 15 parts of Radix Codonopsis, 20 parts of Radix Salviae Miltiorrhizaes, 15 parts of Radix Paeoniae Rubra, 15 parts of Radix Puerariaes, 10 parts of Retinervus Luffae Fructuss, 6 parts of Fructus Liquidambaris, 10 parts of Rhizoma Wenyujin Concisum, 10 parts of Cortex Phellodendris, 15 parts of Semen Cuscutae, 15 parts of Fructus Rubies, 15 parts of Fructus Lycii, 6 parts of Rhizoma Cimicifugaes, 6 parts, Radix Glycyrrhizae.
5. a Chinese medicine extract for the treatment of tinnitus, is characterized in that, described extract is prepared through conventional Traditional Chinese medicine extraction method by the Chinese medicine composition described in any one in claim 1 to 4.
6. the purposes of Chinese medicine extract claimed in claim 5 in the compound Chinese medicinal preparation of preparation treatment tinnitus.
7. treat a compound Chinese medicinal preparation for tinnitus, described preparation acceptable adjuvant on Chinese medicine composition described in any one in claim 1 to 4 and pharmaceutics is made.
8. the compound Chinese medicinal preparation for the treatment of tinnitus according to claim 7, is characterized in that, described preparation is that oral formulations comprises decoction, pill, powder, granule, tablet, capsule, soft extract, drop pill, syrup or oral liquid.
9. a method of preparing the Chinese medicine composition of any one treatment tinnitus in claim 1 to 4, comprises the following steps:
(1) choose any one crude drug in claim 1 to 4, clean, mix by weight ratio;
(2) crude drug is soaked to 30-40 minute according to a conventional method; The water yield was soaked powder;
(3) add medical material gross weight 6-10 decocting doubly and boil 3 times, each 30-50 minute;
(4) merge 3 decoction liquor, filter, and to be condensed into relative density be 1.15-1.35kg/m
3fluid extract;
Adopt conventional preparation technology, can be made into said dosage form on any pharmaceutics, as prepare capsule, powder, oral liquid, granule, pill, unguentum.
10. the Chinese medicine composition described in claim 1 to 4 any one is treated the purposes in tinnitus medicine in preparation.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105596692A (en) * | 2015-12-24 | 2016-05-25 | 马天宝 | Composition for relieving presbycusis and tinnitus and preparation method of composition |
| CN105853759A (en) * | 2015-01-20 | 2016-08-17 | 上海市嘉定区中医医院 | Traditional Chinese medicine composition, its extract product, its preparation, preparation method and application thereof |
| CN113476544A (en) * | 2021-08-16 | 2021-10-08 | 张家港市中医医院 | A Chinese medicinal composition for treating tinnitus and deafness |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194983A (en) * | 2006-12-29 | 2008-06-11 | 周宣岩 | Dropping pills for treating sudden deafness and method for preparing the same |
-
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194983A (en) * | 2006-12-29 | 2008-06-11 | 周宣岩 | Dropping pills for treating sudden deafness and method for preparing the same |
Non-Patent Citations (3)
| Title |
|---|
| 刘文书: "郭连澍治疗突发性聋的经验", 《河北中医》, vol. 30, no. 10, 28 October 2008 (2008-10-28), pages 1013 - 1014 * |
| 宋伟等: "中西医结合治疗突发性耳聋56例", 《西藏医药杂志》, vol. 29, no. 02, 15 June 2008 (2008-06-15), pages 15 - 16 * |
| 张秀芳: "活血聪耳汤配合西药治疗突发性耳聋45例", 《陕西中医》, vol. 30, no. 11, 5 November 2009 (2009-11-05), pages 1511 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853759A (en) * | 2015-01-20 | 2016-08-17 | 上海市嘉定区中医医院 | Traditional Chinese medicine composition, its extract product, its preparation, preparation method and application thereof |
| CN105853759B (en) * | 2015-01-20 | 2019-12-06 | 上海市嘉定区中医医院 | Traditional Chinese medicine composition, extract thereof, preparation method thereof and application thereof |
| CN105596692A (en) * | 2015-12-24 | 2016-05-25 | 马天宝 | Composition for relieving presbycusis and tinnitus and preparation method of composition |
| CN113476544A (en) * | 2021-08-16 | 2021-10-08 | 张家港市中医医院 | A Chinese medicinal composition for treating tinnitus and deafness |
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