CN103638234B - A kind of Chinese medicine composition, preparation and preparation method thereof for the treatment of tinnitus - Google Patents
A kind of Chinese medicine composition, preparation and preparation method thereof for the treatment of tinnitus Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, relate to a kind of treat tinnitus Chinese medicine composition, preparation, and preparation method thereof.Described Chinese medicine composition is made up of the crude drug of following weight: Rhizoma Acori Graminei 8 ~ 15 parts, Rhizoma Chuanxiong 8 ~ 15 parts, the Radix Astragali 20 ~ 30 parts, Radix Codonopsis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 15 ~ 30 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 15 parts, Fructus Liquidambaris 6 ~ 10 parts.Chinese medicine composition of the present invention method of Chinese medicinal conveniently can be prepared into any one and commonly uses oral formulations.Present composition compatibility is precise and appropriate, has opening the orifice and activating blood circulation, the function of vital energy benefiting and the kidney invigorating, confirm through clinical trial, the treatment for tinnitus patient is very effective, and symptom can be made to improve rapidly, majority can obtain healing, has no side effect, and is applicable to the tinnitus that a variety of causes causes.
Description
Technical field:
The present invention relates to technical field of Chinese medicines, particularly a kind of Chinese medicine composition, preparation and preparation method thereof for the treatment of tinnitus.
Background technology:
Tinnitus is a kind of symptom of auditory abnormality, with conscious in ear ring or intracranial ring for main manifestations, simultaneously extraneous normal without corresponding sound source or electricity irritation.Not yet completely clear for the etiology and pathogenesis of tinnitus at present, many general diseases and ear disease all can cause tinnitus.Tinnitus can of short duration or persistence exist, tinnitus adjoint vexed, anxiety is even depressed etc., and the normal physiology of patient and the psychology of giving causes very big puzzlement, clinical onset rate has the trend constantly risen in recent years.
Existing medical science lacks effective Diagnosis and Treat means to tinnitus, and some, for clinical a certain symptom treatment, often falls flat, and the effect of various Chinese and western drugs treatment tinnitus is not satisfied.
Summary of the invention:
The object of this invention is to provide a kind of Chinese medicine composition and compound preparation for the treatment of tinnitus, adopt this compound Chinese medicinal preparation, be used for the treatment of tinnitus symptom common clinically, fundamentally treat tinnitus, reach double effecting a permanent cure of taking stopgap measures, and possess the advantage that curative effect is high, cost is low, toxic and side effects is minimum.
Another object of the present invention is to provide the preparation method of medicine composite preparation in a kind of above-mentioned treatment tinnitus.
The present invention selects Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Puerariae, and Retinervus Luffae Fructus, Fructus Liquidambaris nine taste crude drug combine, and opening the orifice and activating blood circulation, vital energy benefiting and the kidney invigorating, effectively can treat tinnitus.
The present invention adds Rhizoma Wenyujin Concisum, Cortex Phellodendri, Semen Cuscutae, Fructus Rubi, Fructus Lycii again on the basis of above-mentioned nine taste crude drug compositionss, and the crude drug such as Rhizoma Cimicifugae, Radix Glycyrrhizae is assisted a ruler in governing a country, Bushen Tongluo, tying-in coordinating the actions of various ingredients in a prescription, makes the effect for the treatment of tinnitus more obvious.
The brief introduction of above-mentioned raw materials medicine medical material effect is as follows:
Rhizoma Acori Graminei: acrid in the mouth, hardship, temperature.Be included into the heart, stomach, liver three warp.Have expectorant to have one's ideas straightened out, hearing-improing and eyesight improving, removing dampness to restore normal function of the stomach, cold expelling eliminating impediment, effect such as antipruritic of drying.Cure mainly mental confusion due to phlegm, forgetful, the vexed pain of gastral cavilty distension, cold numbness general pain, polyhidrosis around the external genitals pruritus due to damp pathogen etc.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature.Return liver, gallbladder, heart channel.There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.[pharmacopeia essence want] Compendium of Material Medica is recorded: Rhizoma Chuanxiong can dampness, antidiarrheal dysentery, activating QI to alleviate the depression.Cure mainly menoxenia, amenorrhea dysmenorrhea, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Astragali: sweet in the mouth, warm in nature.Return lung, spleen, liver, kidney channel.There is the effect such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.Cure mainly the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Radix Codonopsis: sweet in the mouth, property is put down.Return lung, spleen channel.There is invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Cure mainly deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature.Classify the heart, Liver Channel.Have promoting blood circulation to remove obstruction in the collateral, removing heat from blood is subsided a swelling, the function that relieving restlessness clears away heart-fire.Cure mainly dysmenorrhea, amenorrhea, abdominal mass, blood stasis is had a pain carbuncle sore tumefacting virus, and dysphoria with smothery sensation is uneasy.
Radix Paeoniae Rubra: sour in the mouth is bitter, cold nature.Return Liver Channel.Have and let out liver-fire clearly, removing blood stasis and activating blood flow, the function of pain relieving.Cure mainly menoxenia, the stagnant stomachache of the stasis of blood, amenorrhea note of the ancient Chinese abdominal mass, carbuncle sore tumefacting virus, arthralgia, pain in chest and hypochondrium.
Radix Puerariae: sweet in the mouth, pungent, property are put down.Return spleen, stomach warp.Deliver and bring down a fever, the function of promoting the production of body fluid to quench thirst." treat flesh induce sweat Radix Puerariae first and Radix Bupleuri takes second place ", see " Yaoxing Fu ".Cure mainly: table disease fever without perspiration, rigidity pain on the head and nape, calentura is thirsty, quenches one's thirst, and macule is not saturating, diarrhea due to hypofunction of the spleen.
Retinervus Luffae Fructus: sweet in the mouth, property is put down.Return lung, stomach, Liver Channel.There is effect of heat-clearing and toxic substances removing, promoting blood circulation to remove obstruction in the collateral, inducing diuresis to remove edema.Cure mainly muscles and bones aching, chest and hypochondrium, galactostasis, amenorrhea, painful and swollen testis, have blood in stool, the disease such as metrorrhagia.
Fructus Liquidambaris: bitter in the mouth, property is put down.Return liver, stomach warp.There are promoting the circulation of QI to relieve pain, effect of promoting blood circulation to remove obstruction in the collateral, inducing diuresis to remove edema.Cure mainly limbs arthralgia pain, stomachache, rheumatic arthralgia, edema, distension, carbuncle, scabies eczema.
Rhizoma Wenyujin Concisum: bitter in the mouth, pungent, warm in nature.Return spleen, Liver Channel.There is effect of blood-activating and qi-promoting pain relieving, wind-damp dispelling profit arthralgia pain.Cure mainly the amenorrhea lump in the abdomen of stagnation of QI and blood, the twinge of the breast side of body, traumatic injury; The shoulder and back ache of anemofrigid-damp arthralgia, qi depression to blood stasis, blockage of main and collateral channels.
Cortex Phellodendri: bitter in the mouth, cold in nature.Return kidney, urinary bladder channel.There is the effect of rushing down kidney fire, clearing away damp-heat, solution sore.Cure mainly hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, jaundice, urine retention, stranguria with turbid discharge, leukorrhagia.Disease such as foot swelling and pain in knee, carbuncle skin infection etc.
Semen Cuscutae: sweet in the mouth, warm in nature.Return spleen, liver, kidney channel.There is tonifying liver spleen kidney, controlling nocturnal emission with astringent drugs reducing urination, effect of improving eyesight antidiarrheal.Cure mainly soreness of waist and knee joint, spermatorrhea, incontinence of urine, poor vision, spleen is suffered from a deficiency of the kidney and the disease such as to be rushed down.
Fructus Rubi: sweet in the mouth, acid, warm in nature.Return liver, kidney channel.There is tonifying the kidney to consolidate the essence, effect of supporing yang improving eyesight.Cure mainly sexual impotence, the seminal emission enuresis, frequent micturition, eyes is dim-sighted waits disease.
Fructus Lycii: sweet in the mouth, property are flat.Return liver, lung, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening, lung moistening, effect of improving eyesight.Cure mainly gallbladder insufficiency of kidney-YANG, soreness of the waist and knees, cough due to consumptive disease, the vertigo, keratoconjunctivitis, the disease such as to quench one's thirst.
Rhizoma Cimicifugae: sweet in the mouth, pungent, cold nature.Return lung, spleen, stomach warp.Have deliver, yang invigorating, rash removing toxic substances effect.Cure mainly headache due to pathogenic wind-heat, sinking of QI of middle-JIAO, macule such as not to go out at the disease.
Radix Glycyrrhizae: sweet in the mouth, property are flat.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong etc.
The compound Chinese medicinal preparation that the present invention treats tinnitus with Rhizoma Acori Graminei, Rhizoma Chuanxiong opening the orifice and activating blood circulation for monarch drug, the Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Radix Puerariae benefiting QI for activating blood circulation are ministerial drug, Retinervus Luffae Fructus, Fructus Liquidambaris, Rhizoma Wenyujin Concisum, Cortex Phellodendri, Semen Cuscutae, Fructus Rubi, Fructus Lycii Bushen Tongluo are adjuvant drug, Rhizoma Cimicifugae, Radix Glycyrrhizae tying-in coordinating the actions of various ingredients in a prescription are for making medicine, and compatibility is precise and appropriate, has opening the orifice and activating blood circulation, the function of vital energy benefiting and the kidney invigorating, be used for the treatment of tinnitus, curative effect is reliable, significantly.
Concrete technical scheme of the present invention is:
The invention provides a kind of Chinese medicine composition for the treatment of tinnitus, comprise the crude drug of following weight:
Rhizoma Acori Graminei 8 ~ 15 parts, Rhizoma Chuanxiong 8 ~ 15 parts, the Radix Astragali 20 ~ 30 parts, Radix Codonopsis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 15 ~ 30 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 15 parts, Fructus Liquidambaris 6 ~ 10 parts.
Chinese medicine composition of the present invention, the crude drug of preferred following weight:
Rhizoma Acori Graminei 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Paeoniae Rubra 15 parts, Radix Puerariae 15 parts, Retinervus Luffae Fructus 10 parts, Fructus Liquidambaris 6 parts.
The present invention also provides a kind of Chinese medicine composition for the treatment of tinnitus, and it is made up of the crude drug of following weight:
Rhizoma Acori Graminei 8 ~ 15 parts, Rhizoma Chuanxiong 8 ~ 15 parts, the Radix Astragali 20 ~ 30 parts, Radix Codonopsis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 15 ~ 30 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 15 parts, Fructus Liquidambaris 6 ~ 10 parts; Rhizoma Wenyujin Concisum 8 ~ 12 parts, Cortex Phellodendri 8 ~ 12 parts, Semen Cuscutae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Fructus Lycii 10 ~ 15 parts, Rhizoma Cimicifugae 6 ~ 10 parts, 6 ~ 10 parts, Radix Glycyrrhizae.
Above-mentioned Chinese medicine composition, the crude drug of preferred following weight:
Rhizoma Acori Graminei 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Paeoniae Rubra 15 parts, Radix Puerariae 15 parts, Retinervus Luffae Fructus 10 parts, Fructus Liquidambaris 6 parts, Rhizoma Wenyujin Concisum 10 parts, Cortex Phellodendri 10 parts, Semen Cuscutae 15 parts, Fructus Rubi 15 parts, Fructus Lycii 15 parts, Rhizoma Cimicifugae 6 parts, 6 parts, Radix Glycyrrhizae.
The present invention also provides a kind of Chinese medicine extract for the treatment of tinnitus, and described extract is prepared through conventional Traditional Chinese medicine extraction method by above-mentioned any one Chinese medicine composition.
The purposes of described Chinese medicine extract in the compound Chinese medicinal preparation of preparation treatment tinnitus.
The present invention also provides a kind of compound Chinese medicinal preparation for the treatment of tinnitus, and described preparation is made up of acceptable adjuvant on above-mentioned any one Chinese medicine composition and pharmaceutics.
Preparation of the present invention is preferably oral formulations.Described oral formulations can be decoction, pill, powder, granule, tablet, capsule, soft extract, drop pill, syrup or oral liquid.According to the difference of route of administration, the present composition also can be made into general external preparation, as unguentum etc.But be not limited to above-mentioned dosage form, according to the method that in field of traditional Chinese, oneself knows, after aforementioned pharmaceutical compositions being extracted by own perception method, various different dosage form can be made according to clinical needs.
The present invention also provides a kind of method preparing the Chinese medicine composition of above-mentioned treatment tinnitus,
Comprise the following steps:
(1) choose any one crude drug in above-mentioned composition, clean, mix by weight ratio,
(2) crude drug is soaked 30-40 minute according to a conventional method; The dipped powder of the water yield;
(3) medical material gross weight 6-10 soak by water doubly 3 times are added, each 30-50 minute;
(4) merge 3 decoction liquor, filter, and to be condensed into relative density be 1.15-1.35k
g/ m
3fluid extract;
Adopt conventional fabrication process, said dosage form on any one pharmaceutics can be prepared into, as capsule, powder, oral liquid, granule, pill, soft extract.
Chinese medicine composition of the present invention can also for the preparation of in the medicine for the treatment of tinnitus.
The present invention's herbal raw material medicine used all can be buied from Chinese medicine shop, and its specification meets national medical standards.Usage and dosage: dosage of the present invention depends on concrete dosage form, the factors such as patient age, body weight, health status.
Beneficial effect of the present invention:
Chinese medicine composition compatibility of the present invention is precise and appropriate, there is opening the orifice and activating blood circulation, the function of vital energy benefiting and the kidney invigorating, confirm through clinical trial, the treatment for tinnitus patient is very effective, and symptom can be made to improve rapidly, majority can obtain healing, have no side effect, be applicable to the tinnitus that a variety of causes causes, there is good prospect of the application and market prospect.
Detailed description of the invention:
Embodiment of the present invention medical material used, all purchased from Chinese Medicinal Materials Co, meets Pharmacopoeia of People's Republic of China standard.
Embodiment 1: the preparation of granule
Each crude drug is taken according to following weight parts proportioning:
Rhizoma Acori Graminei 8g, Rhizoma Chuanxiong 8g, Radix Astragali 25g, Radix Codonopsis 12g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 10g, Radix Puerariae 20g, Retinervus Luffae Fructus 15g, Fructus Liquidambaris 8g;
Clean, mix by weight ratio, crude drug is soaked 40 minutes according to a conventional method; The dipped powder of the water yield; Add the soak by water 3 times of medical material gross weight 6 times, each 30 minutes; Merge 3 decoction liquor, filter, and to be condensed into relative density be 1.15kg/m
3fluid extract; The conveniently preparation method of granule, by the drying of concentrated fluid extract, is ground into 100 ~ 120 object medicated powder, spray granulation, dry, subpackage.
Embodiment 2: the preparation of granule
Each crude drug is taken according to following weight parts proportioning:
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g;
Clean, mix by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The dipped powder of the water yield; Add the soak by water 3 times of medical material gross weight 8 times, each 40 minutes; Merge 3 decoction liquor, filter, and to be condensed into relative density be 1.20kg/m
3fluid extract; The conveniently preparation method of granule, by the drying of concentrated fluid extract, is ground into 100 ~ 120 object medicated powder, spray granulation, dry, subpackage.
Embodiment 3: the preparation of granule
Each crude drug is taken according to following weight parts proportioning:
Rhizoma Acori Graminei 15g, Rhizoma Chuanxiong 15g, Radix Astragali 20g, Radix Codonopsis 10g, Radix Salviae Miltiorrhizae 30g, Radix Paeoniae Rubra 20g, Radix Puerariae 10g, Retinervus Luffae Fructus 12g, Fructus Liquidambaris 10g.
Each crude drug is cleaned, mixes by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The dipped powder of the water yield; Add the soak by water 3 times of medical material gross weight 10 times, each 50 minutes; Merge 3 decoction liquor, filter, and to be condensed into relative density be 1.3kg/m
3fluid extract; The conveniently preparation method of granule, by the drying of concentrated fluid extract, is ground into 100 ~ 120 object medicated powder, spray granulation, dry, subpackage.
The preparation of embodiment 4 granule
Each crude drug is taken according to following proportioning,
Rhizoma Acori Graminei 8g, Rhizoma Chuanxiong 8g, Radix Astragali 25g, Radix Codonopsis 12g, Radix Salviae Miltiorrhizae 15g, Radix Paeoniae Rubra 10g, Radix Puerariae 20g, Retinervus Luffae Fructus 15g, Fructus Liquidambaris 8g, Rhizoma Wenyujin Concisum 12g, Cortex Phellodendri 8g, Semen Cuscutae 20g, Fructus Rubi 10g, Fructus Lycii 12g, Rhizoma Cimicifugae 8g, Radix Glycyrrhizae 10g.
Each crude drug is cleaned, mixes by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The dipped powder of the water yield; Add the soak by water 3 times of medical material gross weight 6 times, each 30 minutes; Merge 3 decoction liquor, filter, and to be condensed into relative density be 1.15kg/m
3thick paste; The conveniently preparation method of granule, by the drying of concentrated fluid extract, is ground into 100 ~ 120 object medicated powder, spray granulation, dry, subpackage.
The preparation of embodiment 5 granule
Each crude drug is taken according to following proportioning, for subsequent use;
Rhizoma Acori Graminei 15g, Rhizoma Chuanxiong 15g, Radix Astragali 20g, Radix Codonopsis 10g, Radix Salviae Miltiorrhizae 30g, Radix Paeoniae Rubra 20g, Radix Puerariae 10g, Retinervus Luffae Fructus 12g, Fructus Liquidambaris 10g, Rhizoma Wenyujin Concisum 8g, Cortex Phellodendri 12g, Semen Cuscutae 10g, Fructus Rubi 20g, Fructus Lycii 10g, Rhizoma Cimicifugae 10g, Radix Glycyrrhizae 8g.
Each crude drug is cleaned, mixes by weight ratio, crude drug is soaked 40 minutes according to a conventional method; The dipped powder of the water yield; Add the soak by water 3 times of medical material gross weight 8 times, each 40 minutes; Merge 3 decoction liquor, filter, and to be condensed into relative density be 1.2kg/m
3thick paste; The conveniently preparation method of granule, by the drying of concentrated fluid extract, is ground into 100 ~ 120 object medicated powder, spray granulation, dry, subpackage.
The preparation of embodiment 6 granule
Each crude drug is taken according to following proportioning, for subsequent use;
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g, Rhizoma Wenyujin Concisum 10g, Cortex Phellodendri 10g, Semen Cuscutae 15g, Fructus Rubi 15g, Fructus Lycii 15g, Rhizoma Cimicifugae 6g, Radix Glycyrrhizae 6g.
Each crude drug is cleaned, mixes by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The dipped powder of the water yield; Add the soak by water 3 times of medical material gross weight 10 times, each 50 minutes; Merge 3 decoction liquor, filter, and to be condensed into relative density be 1.3kg/m
3fluid extract; The conveniently preparation method of granule, by the drying of concentrated fluid extract, is ground into 100 ~ 120 object medicated powder, spray granulation, dry, subpackage.
The preparation of embodiment 7 capsule
Each crude drug is taken according to following proportioning, for subsequent use;
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g, Rhizoma Wenyujin Concisum 10g, Cortex Phellodendri 10g, Semen Cuscutae 15g, Fructus Rubi 15g, Fructus Lycii 15g, Rhizoma Cimicifugae 6g, Radix Glycyrrhizae 6g.
Each crude drug is cleaned, mixes by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The dipped powder of the water yield; Add the soak by water 3 times of medical material gross weight 10 times, each 50 minutes; Merge 3 decoction liquor, filter, and to be condensed into relative density be 1.15kg/m
3thick paste;
The conveniently operational approach of capsule, the fluid extract of obtained mix homogeneously is concentrated, adds pharmaceutic adjuvant, by component mix homogeneously, granulate, adopt conventional capsule preparation method to fill and make capsule.
The preparation of embodiment 8 oral liquid
Each crude drug is taken according to following proportioning, for subsequent use;
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g, Rhizoma Wenyujin Concisum 10g, Cortex Phellodendri 10g, Semen Cuscutae 15g, Fructus Rubi 15g, Fructus Lycii 15g, Rhizoma Cimicifugae 6g, Radix Glycyrrhizae 6g.
Each crude drug is cleaned, mixes by weight ratio, crude drug is soaked 40 minutes according to a conventional method; The dipped powder of the water yield; Add the soak by water 3 times of medical material gross weight 10 times, each 50 minutes; Merge 3 decoction liquor, filter, and to be condensed into relative density be 1.35kg/m
3fluid extract;
The conveniently preparation method of oral liquid, concentrates the fluid extract of mix homogeneously, alcohol settling 1-2 time, filters, concentrated, and aqueous precipitation filters, subpackage sterilizing; After inspection, packed products, makes oral liquid.
The preparation of embodiment 9 decoction
Each crude drug is taken according to following proportioning, for subsequent use;
Rhizoma Acori Graminei 10g, Rhizoma Chuanxiong 10g, Radix Astragali 30g, Radix Codonopsis 15g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 15g, Radix Puerariae 15g, Retinervus Luffae Fructus 10g, Fructus Liquidambaris 6g, Rhizoma Wenyujin Concisum 10g, Cortex Phellodendri 10g, Semen Cuscutae 15g, Fructus Rubi 15g, Fructus Lycii 15g, Rhizoma Cimicifugae 6g, Radix Glycyrrhizae 6g.
Each crude drug is cleaned, mixes by weight ratio, crude drug is soaked 30 minutes according to a conventional method; The dipped powder 2 ~ 3cm of the water yield is advisable, and decocts with water 3 times, boils with high heat to use slow fire again instead and decoct 30 ~ 40 minutes, merges 3 decoction liquor, filters medicinal residues and takes concoction and get final product.
The present invention treats tinnitus clinical trial and interpretation of result
1 data and method
1.1 object of study
Object of study is selected from the tinnitus patient that PLA General Hospital was accepted for medical treatment year August in August, 2007 to 2013, totally 160 examples, wherein female patient 72 example, male 88 example; Age be 25-67 year not etc., average (43.4 ± 7.8) year.160 routine patients are divided into matched group and experimental group at random, and often organize 80 examples, two groups of patients without significant significant difference (P>0.05), have comparability in sex, age and coincident with severity degree of condition etc.
1.2 Tinnitus volume classifications
0 grade: without tinnitus; 1 grade: Tinnitus volume is minimum, seemingly have like nothing; 2 grades: Tinnitus volume is slight, but certainly can listen and obtain; 3 grades: moderate amplitude, there is minimal effect to work and life; 4 grades: tinnitus is sound comparatively, take sb's mind off sth, affect Working Life; 5 grades: tinnitus is very loud, severe jamming life and work and rest; 6 grades: tinnitus is sound extremely, be difficult to stand.
1.3 screening criteria
Inclusive criteria: 1. two groups of patients all meet the diagnostic criteria of tinnitus in " ear,nose & throat therapeutics " and " Otorhinolaryngology of TCM "; 2. Tinnitus volume all should be greater than II level; 3. this research of voluntary participation, and sign Informed Consent Form.
Exclusion standard: 1. tinnitus person caused by wound, tumor and systemic disease; 2. the tinnitus person that causes such as acute and chronic otitis media and Nervous and Mental Factors; 3. gestation or women breast-feeding their children; 4. the tinnitus patient of severe cardiac cerebrovascular disease, liver, kidney and disease of hematopoietic system is associated with; 5. the patient of other clinical trial is participated in nearly 3 months.
1.4 method
1. matched group: this group patient gives flunarizine hydrochloride prolixity capsule 5mg, takes, every day 1 time before sleeping after meal.Vitamin B12 once a day, an intramuscular injection 0.5mg;
2. experimental group: often organize medicine composite preparation decoction (water decoction) in patient oral the present invention, every day potion, 1 dose of 200ml, point 2 to 3 decoction being taken warmly.Within 14 days, be a course for the treatment of, totally 2 courses for the treatment of, treatment terminates rear observe the curative effect.
1.5 criterion of therapeutical effect
Parameters for observation on effect is with reference to " new Chinese medicine treatment tinnitus guideline of clinical investigations ": 1. effective: tinnitus symptom disappears completely or only occurs once in a while under night and quiet environment, audition substantially to return to when not falling ill state or without obvious dysaudia, maintains more than two weeks and do not recur; 2. effective: tinnitus symptom is slightly alleviated, show effect in being transferred to by persistence only occurs under quiet environment or only under noisy environment; 3. invalid: tinnitus and situation and before taking medicine without obviously changing, also even there is deterioration without changing in sign.Total effective rate=1.+2..
1.6 statistical procedures
This research adopts SPSS17.0 statistics software, and adopt X 2 test, P<0.05 is that difference has statistical significance.
2 results
2.1 efficacy result
After the treatment of 3 courses for the treatment of, effective 15 examples of matched group patient, effective 36 examples, invalid 29 examples, total effective rate 63.8%; Effective 28 examples of experimental group patient, effective 37 examples, invalid 15 examples, total effective rate 81.3%.The total effective rate (81.3%) of experimental group and obvious effective rate (35.0%) are apparently higher than the total effective rate (63.8%) of matched group and obvious effective rate (18.8%), and the inefficiency (18.8%) that difference all has statistical significance (P<0.05) experimental group is starkly lower than matched group (36.3%), its difference also has significant statistical significance (P<0.05).In table 1.
Table l two groups of patients after curative treatment's contrasts
Note: * represents to compare with matched group have significant significant difference, P<0.05
Result shows, compound Chinese medicinal preparation of the present invention has significant curative effect to treatment tinnitus patient.
Claims (8)
1. treat a Chinese medicine composition for tinnitus, it is characterized in that, it is made up of the crude drug of following weight:
Rhizoma Acori Graminei 8 ~ 15 parts, Rhizoma Chuanxiong 8 ~ 15 parts, the Radix Astragali 20 ~ 30 parts, Radix Codonopsis 10 ~ 15 parts, Radix Salviae Miltiorrhizae 15 ~ 30 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 15 parts, Fructus Liquidambaris 6 ~ 10 parts; Rhizoma Wenyujin Concisum 8 ~ 12 parts, Cortex Phellodendri 8 ~ 12 parts, Semen Cuscutae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Fructus Lycii 10 ~ 15 parts, Rhizoma Cimicifugae 6 ~ 10 parts, 6 ~ 10 parts, Radix Glycyrrhizae.
2. treat the Chinese medicine composition of tinnitus according to claim 1, it is characterized in that, it is made up of the crude drug of following weight:
Rhizoma Acori Graminei 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Astragali 30 parts, Radix Codonopsis 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Paeoniae Rubra 15 parts, Radix Puerariae 15 parts, Retinervus Luffae Fructus 10 parts, Fructus Liquidambaris 6 parts, Rhizoma Wenyujin Concisum 10 parts, Cortex Phellodendri 10 parts, Semen Cuscutae 15 parts, Fructus Rubi 15 parts, Fructus Lycii 15 parts, Rhizoma Cimicifugae 6 parts, 6 parts, Radix Glycyrrhizae.
3. treat a Chinese medicine extract for tinnitus, it is characterized in that, described extract is prepared through conventional Traditional Chinese medicine extraction method by the Chinese medicine composition in claim 1 to 2 described in any one.
4. the purposes of Chinese medicine extract according to claim 3 in the compound Chinese medicinal preparation of preparation treatment tinnitus.
5. treat a compound Chinese medicinal preparation for tinnitus, described preparation is made up of acceptable adjuvant on Chinese medicine composition described in any one in claim 1 to 2 and pharmaceutics.
6. the compound Chinese medicinal preparation for the treatment of tinnitus according to claim 5, it is characterized in that, described preparation is that oral formulations comprises decoction, pill, powder, granule, tablet, capsule, soft extract, drop pill, syrup or oral liquid.
7. prepare a method for the Chinese medicine composition of any one treatment tinnitus in claim 1 to 2, comprise the following steps:
(1) choose any one crude drug in claim 1 to 2, clean, mix by weight ratio;
(2) crude drug is soaked 30-40 minute according to a conventional method; The dipped powder of the water yield;
(3) medical material gross weight 6-10 soak by water doubly 3 times are added, each 30-50 minute;
(4) merge 3 decoction liquor, filter, and to be condensed into relative density be 1.15-1.35kg/m
3fluid extract;
Adopt conventional fabrication process, can be made into said capsule, powder, oral liquid, granule, pill or unguentum on any one pharmaceutics.
8. the purposes of the Chinese medicine composition described in claim 1 to 2 any one in preparation treatment tinnitus medicine.
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| CN105853759B (en) * | 2015-01-20 | 2019-12-06 | 上海市嘉定区中医医院 | Traditional Chinese medicine composition, extract thereof, preparation method thereof and application thereof |
| CN105596692A (en) * | 2015-12-24 | 2016-05-25 | 马天宝 | Composition for relieving presbycusis and tinnitus and preparation method of composition |
| CN113476544A (en) * | 2021-08-16 | 2021-10-08 | 张家港市中医医院 | A Chinese medicinal composition for treating tinnitus and deafness |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101194983A (en) * | 2006-12-29 | 2008-06-11 | 周宣岩 | Dropping pills for treating sudden deafness and method for preparing the same |
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| CN101194983A (en) * | 2006-12-29 | 2008-06-11 | 周宣岩 | Dropping pills for treating sudden deafness and method for preparing the same |
Non-Patent Citations (3)
| Title |
|---|
| 中西医结合治疗突发性耳聋56例;宋伟等;《西藏医药杂志》;20080615;第29卷(第02期);15-16 * |
| 活血聪耳汤配合西药治疗突发性耳聋45例;张秀芳;《陕西中医》;20091105;第30卷(第11期);1511 * |
| 郭连澍治疗突发性聋的经验;刘文书;《河北中医》;20081028;第30卷(第10期);1013-1014 * |
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