CN105250614A - Method for preparing throat coughing atomization inhalation powder - Google Patents
Method for preparing throat coughing atomization inhalation powder Download PDFInfo
- Publication number
- CN105250614A CN105250614A CN201510803859.0A CN201510803859A CN105250614A CN 105250614 A CN105250614 A CN 105250614A CN 201510803859 A CN201510803859 A CN 201510803859A CN 105250614 A CN105250614 A CN 105250614A
- Authority
- CN
- China
- Prior art keywords
- semen
- parts
- radix
- cough
- throat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for preparing throat coughing atomization inhalation powder to solve the problem of laryngeal cough treatment. The method is characterized by comprising the following steps: (1) extracting volatile oils from pawpaws, wintercreeper, ailanthus altissima swingle, pseudodrynaria coronans, semen aesculi, cinnamomum camphora, solanum lyratum thunb, semen lini and resina liquidambaris coarse powder to obtain mixed volatile oil and medicinal dregs for later use; (2) uniformly mixing pyrola rotundifolia, tricyrtis root and semen euryales with the medicinal dregs obtained in the step (1), performing water extraction and alcohol precipitation, filtering to remove alcohol, performing ultrafiltration by a microporous membrane, concentrating and drying the filtrate to obtain a primary material; and (3) spraying the volatile oil obtained in the step (1) into the primary material obtained in the step (2), uniformly mixing, grinding, screening by a 100-mesh screen, and sterilizing. Clinical experiments prove that the throat coughing atomization inhalation powder has the characteristics of good curative effect and relatively high safety when being used for treating laryngeal cough, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of larynx and cough Neulized inhalation powder, preparation method thereof.
Background technology
Laryngeal cough, is called for short larynx and coughs, refer to the cough that bottleneck throat pathological changes causes.Clinical characters is: cough inducement is various, and what have coughs because of dry pharynx, and what have coughs because of itching throat, and what have coughs because sucking cold air, and what have coughs because speaking, and in paroxysmal cough, starts as intermittence, with the passing of time develops into persistent cough, recurrent exerbation.Its pathogeny is: bottleneck throat retropharyneal folliculosis, or with mucous gland pipe choking under larynx mucosa, mucus retention, many factors causes the neural Gao Min in laryngopharynx portion, and coughre flex pathologic strengthens.Mostly anti-inflammatory treatment is adopted in clinical treatment, but bad by effects of antibiotics, a little mitigation can only be played, and very obstinate, bring huge misery to patient.
Therefore, current larynx is coughed treatment and is mainly relied on Chinese medicine, existing pathogenesis complys with exopathogen invasion and attack, internal organs virtual loss etc. more, use is relieved inflammation or internal heat (lung-fire, heart-fire, stomach-fire), medicine that is nourshing Yin and drynsessmoistening prescription, smooth throat to stop cough is treated, but in fact because partial laryngeal coughs patient's not simple " cough caused by dryness ", dry pharynx, itching throat, cold air, speak etc. can cause cough, the pathology even had is shown as that mucus retention under larynx mucosa causes, and can not obtain good effect because " relieve inflammation or internal heat and moisturize " simply.Use antitussive medicine, sometimes central antitussive effect can be passed through in a short time, reduce coughre flex, reach antitussive object, but patient is recurrent exerbation in a week to two weeks often, its reason is that the mucosa infection swallowing rear wall does not improve, after antitussive medicine event resolves, coughre flex is replied, and symptom is staged a comeback.Especially for pediatric patient, uncontrollable coughre flex, slight bottleneck throat discomfort can bring out cough, and for child patient, has antitussive medicine and use contraindication.
At present clinical also have use Neulized inhalation to carry out treating, but current inhalable aerosol drug is lower respiratory tract mainly for object, for bottleneck throat mucosa, the bad local application's effect that causes of adhesive force due to inhalable aerosol drug is bad, but use mucosa attachment adjuvant, probably strengthen again throat membranes to stimulate, strengthen cough.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of larynx to cough Neulized inhalation powder, preparation method thereof, by using this inhalable aerosol drug both can alleviate laryngeal cough cough symptom, reducing patient suffering, can reduce relapse rate again.
The technical scheme that the present invention solves its technical problem is: a kind of larynx coughs Neulized inhalation powder, preparation method thereof, it is characterized in that being prepared from by the crude drug of following weight proportion: precipice Rhizoma Zingiberis Recens 12 ~ 20 parts, Herba pyrolae japonicae 12 ~ 20 parts, Fructus Chaenomelis 10 ~ 33 parts, Caulis Seu Folium Euonymi Fortunei 3 ~ 12 parts, Radix Tricyrtidis pilosae 12 ~ 20 parts, Semen Aesculi 12 ~ 20 parts, Radix Cinnamomi porrecti 12 ~ 20 parts, Fructus Ailanthi 3 ~ 12 parts, Semen Lini 3 ~ 12 parts, Resina Liquidambaris 10 ~ 25 parts, 12 ~ 20 parts, Gorgon fruit, Herba Solani Lyrati 1 ~ 5 part.
Chinese medicine of the present invention can be prepared from by following method:
(1) Fructus Chaenomelis, Caulis Seu Folium Euonymi Fortunei, Fructus Ailanthi, Radix Cinnamomi porrecti, precipice Rhizoma Zingiberis Recens, Semen Aesculi, Herba Solani Lyrati, Semen Lini, Resina Liquidambaris coarse powder are extracted volatile oil with vapor distillation respectively, obtain Mixed chaotic sequences and medicinal residues are for subsequent use;
(2) by gained medicinal residues mixing in Herba pyrolae japonicae, Radix Tricyrtidis pilosae, Gorgon fruit and step 1, add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill after filtered through gauze; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, airtight standing 48h, filter, through microporous membrane ultrafiltration after filtrate removing ethanol, filtrate concentrate drying, draws just material;
(3) sprayed into by gained volatile oil in step 1 during step 2 gained just expects, mixing, after pulverizing 100 mesh sieves, sterilizing formed.
Wherein said: Herba pyrolae japonicae is the dry herb of Pyrolaceae plant Herba pyrolae japonicae PyrolacallianthaH.Andres or ovum leaf Herba pyrolae japonicae PyroladecorataH.Andres; Nature and flavor are sweet, bitter, temperature; Return liver, kidney channel; Merit can tonify deficiency, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation;
Precipice Rhizoma Zingiberis Recens is fern Polypodiaceae precipice ginger precipice Rhizoma Zingiberis Recens Pseudodrynariacoronans(Wall.) Ching, is used as medicine with root stock.Nature and flavor are bitter, micro-puckery, temperature.Function cures mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.
Fructus Chaenomelis is rosaceous plant chaenomeles lagenaria Chaenomelesspeciosa(Sweet) the dry almost ripe fruit of Nakai.Nature and flavor acid, temperature.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.
Caulis Seu Folium Euonymi Fortunei is Celastraceae burning buss Caulis Seu Folium Euonymi Fortunei Euonymusfortunei(Turcz.) Hand.-Mazz., is used as medicine with stem, leaf.Nature and flavor are bitter, sweet.Function cures mainly: dissipating blood stasis stops blooding, relaxing muscles and tendons and activating QI and blood in the collateral.
Radix Tricyrtidis pilosae is the root of liliaceous plant pubescence Herba Tricyrtidis macropodae.Cure mainly traumatic injury.
Semen Aesculi is Hippocastanaceae plant Aesculus chinensis Bunge AesculuschinensisBge., Radix Aesculi AesculuschinensisBge.var.chekiangensis(HuetFang) dry mature seed of Fang or Aesculus AesculuswilsoniiRehd..Nature and flavor are sweet, temperature.Return liver, stomach warp.Regulating the flow of QI to ease the stomach, and stomach and alleviating pain.
Radix Cinnamomi porrecti, is the aiphyllium of canella Camphor tree, uses its branch and leaf; Nature and flavor are micro-pungent, temperature; Merit can warming middle-JIAO to relieve pain, ward off dirty and in, expelling wind and removing dampness;
Fructus Ailanthi is quassia ailanthus altissima (mill.) swingle Ailanthusaltissima(Mill.) fruit of Swingle.Nature and flavor: bitter, cool.Function cures mainly: clearing away heat and promoting diuresis, pain relieving, hemostasis.
Semen Lini is the dry mature seed of flax family (Linaceae) linum Caulis et Folium Lini LinumusitatissimumL..Nature and flavor are sweet, tepor.Function cures mainly: loosening bowel to relieve constipation, nourishing blood to expel wind.For dryness of the intestine constipation; Old man's xerosis cutis Scaling, allergic dermatitis, skin pruritus; Skin infection eczema.
Resina Liquidambaris is the dry resin of Hamamelidaceae Plants Chinese sweet gum LiquidambarformosanaHance.Pungent, the micro-hardship of nature and flavor, flat.Return lung, spleen channel.Function cures mainly: promoting blood circulation and stopping pain, removing toxic substances, granulation promoting, removing heat from blood.
Gorgon fruit is the dry mature kernal of nymphaeaceae plant Gorgon euryale EuryaleferoxSalisb..Nature and flavor are sweet, puckery, flat.Gui Jing returns spleen, kidney channel.Function cures mainly: supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.
Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati SolanumlyratumThunb..Sweet in the mouth; Bitter; Cold in nature.Return liver; Gallbladder; Kidney channel.Merit can clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.
In prior art with " relieve inflammation or internal heat (lung-fire, heart-fire, stomach-fire), nourshing Yin and drynsessmoistening prescription " to effect a permanent cure, take stopgap measures with " smooth throat to stop cough ", but in fact because partial laryngeal coughs patient's not simple " cough caused by dryness ", dry pharynx, itching throat, cold air, speak etc. can cause cough, the pathology even had is shown as that mucus retention under larynx mucosa causes, and can not obtain good effect because " relieve inflammation or internal heat and moisturize " simply.Use antitussive medicine, sometimes central antitussive effect can be passed through in a short time, reduce coughre flex, reach antitussive object, but patient is recurrent exerbation in a week to two weeks often, its reason is that the mucosa infection of pharynx rear wall and air flue high sensitivity are not improved, after antitussive medicine event resolves, coughre flex is replied, and symptom is staged a comeback.
Compared with prior art, the present invention has following characteristics:
1, this prescription do not use relieve inflammation or internal heat, moisturize, antitussive medicine, mucus retention under coughing the visible retropharyneal folliculosis of pathology and larynx mucosa as can be seen from larynx, larynx is coughed not simple " dryness of the lung ", but steam forms at lung network skewness, therefore we reach the object reducing coughre flex sensitivity by warming YANG aproll, tracking lung network, thus reduce the generation of irritable cough;
2, in side with Herba pyrolae japonicae, precipice Rhizoma Zingiberis Recens for core, Herba pyrolae japonicae water extract can suppress the generation of skin-sensitizing antibodies in mice serum and house mouse spleen hemolytic cell, and precipice Rhizoma Zingiberis Recens can lead to lung network, and in order to reduce airway resistance, the two coordinates aproll, tracking lung network; Larynx for ammonia and Oleum Terebinthinae modeling coughs guinea pig model, Herba pyrolae japonicae, precipice Rhizoma Zingiberis Recens geometric ratio mixing water decocting liquid Neulized inhalation, (5min coughs number of times: medicine group 18.5 ± 8.2 effectively can to reduce guinea pig cough's frequency, model group 37.2 ± 10.8, the two compares, difference has statistical significance, P<0.05);
3, Fructus Chaenomelis is used for Liver Channel disease originally, but inventor's clinical practice Fructus Chaenomelis decocting liquid Neulized inhalation, airway mucus can be alleviated generate, zoopery confirms, effectively can reduce the expression of rat model air flue mucin, MUC5AC albumen, and then minimizing mucus retention stimulates the cough caused for pharyngeal mucosa;
4, Caulis Seu Folium Euonymi Fortunei, Radix Tricyrtidis pilosae are in order to auxiliary monarch drug, strengthen its row and to fall apart ability;
5, Semen Aesculi, Radix Cinnamomi porrecti mean incubation yang-energy, and gas moves with sun, and helps Fructus Chaenomelis to disperse aqueous vapor, and Semen Aesculi also has the function of therapeutic method to keep the adverse QI flowing downwards improving inspiration by invigorating kidney-QI;
6, the volatile oil of Fructus Ailanthi decocting liquid and vapor extraction all presents comparatively highly acid, is conducive to the pH value of regulating drug, and the biological alkaline components of antagonism other drug is for the stimulation of mucosa, and therefore consumption is greater than conventional amount used;
7, Semen Lini can the excessive aproll band of gas of antagonism come impairment of body fluid;
8,8, the use meaning of Resina Liquidambaris and Gorgon fruit is all to increase bottleneck throat medicine adhesive force, and Resina Liquidambaris is micromolecule natural gum, is easy to ascension, can guide drugs adhere in bottleneck throat rapidly, and Tang Materia Medica records Resina Liquidambaris " acrid in the mouth is bitter, flat; nontoxic ", " working hard and putting down is Jin get Huo, with unboiled water ", nature and flavor are put down, then without the anxiety of cold and heat, also contain irritating compositions such as pinene unlike other resinae medicines, apply to Neulized inhalation, safe and reliable;
9, getting Herba Solani Lyrati in a small amount, is the meaning of using corrigent, the raw endogenous dryness to prevent warm drugs thing too.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: precipice Rhizoma Zingiberis Recens 15g, Herba pyrolae japonicae 15g, Fructus Chaenomelis 20g, Caulis Seu Folium Euonymi Fortunei 12g, Radix Tricyrtidis pilosae 15g, Semen Aesculi 15g, Radix Cinnamomi porrecti 15g, Fructus Ailanthi 12g, Semen Lini 12g, Resina Liquidambaris 20g, Gorgon fruit 15g, Herba Solani Lyrati 2g.
The preparation method of embodiment 1 is: precipice Rhizoma Zingiberis Recens, Herba pyrolae japonicae, Fructus Chaenomelis, Caulis Seu Folium Euonymi Fortunei, Radix Tricyrtidis pilosae, Semen Aesculi, Radix Cinnamomi porrecti, Fructus Ailanthi, Semen Lini, Resina Liquidambaris, Gorgon fruit, Herba Solani Lyrati mixing and water adding are decocted, filtrate is got after 33 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, use two layers of filtered through gauze again, gained filtrate 60 DEG C ~ 70 DEG C is concentrated into density 1.15, airtight standing 8h after concentrated solution cooling, filter, to obtain final product.
Embodiment 2, crude drug weight proportion: precipice Rhizoma Zingiberis Recens 12 parts, Herba pyrolae japonicae 12 parts, Fructus Chaenomelis 10 parts, Caulis Seu Folium Euonymi Fortunei 3 parts, Radix Tricyrtidis pilosae 12 parts, Semen Aesculi 12 parts, Radix Cinnamomi porrecti 12 parts, Fructus Ailanthi 3 parts, Semen Lini 3 parts, Resina Liquidambaris 10 parts, 12 parts, Gorgon fruit, Herba Solani Lyrati 1 part.
Embodiment 3, crude drug weight proportion: precipice Rhizoma Zingiberis Recens 15 parts, Herba pyrolae japonicae 15 parts, Fructus Chaenomelis 20 parts, Caulis Seu Folium Euonymi Fortunei 12 parts, Radix Tricyrtidis pilosae 15 parts, Semen Aesculi 15 parts, Radix Cinnamomi porrecti 15 parts, Fructus Ailanthi 12 parts, Semen Lini 12 parts, Resina Liquidambaris 20 parts, 15 parts, Gorgon fruit, Herba Solani Lyrati 2 parts.
Embodiment 4, crude drug weight proportion: precipice Rhizoma Zingiberis Recens 20 parts, Herba pyrolae japonicae 20 parts, Fructus Chaenomelis 33 parts, Caulis Seu Folium Euonymi Fortunei 12 parts, Radix Tricyrtidis pilosae 20 parts, Semen Aesculi 20 parts, Radix Cinnamomi porrecti 20 parts, Fructus Ailanthi 12 parts, Semen Lini 12 parts, Resina Liquidambaris 25 parts, 20 parts, Gorgon fruit, Herba Solani Lyrati 5 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Fructus Chaenomelis, Caulis Seu Folium Euonymi Fortunei, Fructus Ailanthi, Radix Cinnamomi porrecti, precipice Rhizoma Zingiberis Recens, Semen Aesculi, Herba Solani Lyrati, Semen Lini, Resina Liquidambaris coarse powder are extracted volatile oil with vapor distillation respectively, obtain Mixed chaotic sequences and medicinal residues are for subsequent use;
(2) by gained medicinal residues mixing in Herba pyrolae japonicae, Radix Tricyrtidis pilosae, Gorgon fruit and step 1, add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill after filtered through gauze; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, airtight standing 48h, filter, through microporous membrane ultrafiltration after filtrate removing ethanol, filtrate concentrate drying, draws just material;
(3) sprayed into by gained volatile oil in step 1 during step 2 gained just expects, mixing, after pulverizing 100 mesh sieves, sterilizing formed.
The efficient combination of said medicine, coordinates mutually, effectively reach the effect played laryngeal cough treatment, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: be diagnosed as laryngeal cough in May, 2012 ~ in May, 2015 and the age be greater than 14 years old patient 96 example, wherein male patient is 59 examples, women's sufferer is 37 examples, age is between 14 ~ 65 years old, mean age is 41.2 years old, the course of disease 0.1 ~ 5 month, wherein has patient 78 example of recurrent exerbation medical history.Diagnosis basis is with reference to " modern Chinese medicine clinical diagnostics ": 1. clinical manifestation is for very itch in burst larynx portion and bring out paroxysmal dry cough, notably coughs and feels sick, in seriality, spastic; 2. auscultation of lung is without exception, and rabat, routine blood test, erythrocyte sedimentation rate etc. check performance all without exception; 3. lower respiratory infection, tuberculosis, tumor etc. are got rid of.
1.1.2 divide into groups: be divided into matched group 32 example, liquid group 33 example and powder group 31 example.Compare in sex, age, the course of disease, severity Scaling, cough integration etc. before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 inhalable aerosol drug is selected: matched group uses sore-throat relieving atomization mixture (prescription: Herba Menthae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Fructus Arctii, Periostracum Cicadae, Semen Sterculiae Lychnophorae, Radix Ophiopogonis, Radix Platycodonis, Fructus Schisandrae Chinensis) with " relieve inflammation or internal heat, moisturize, antitussive " effect according to list of references; Liquid group is with the embodiment of the present invention 1 gained Neulized inhalation liquid, and each using dosage is equivalent to crude drug amount 40g; Powder group is with gained sterile powder in the embodiment of the present invention 3, and each using dosage is equivalent to crude drug amount 40g.
1.2.2 Therapeutic Method: three groups of patients all adopt Treated by Inhalation of Ultrasonic Spray 14d, and concrete atomization method is: by medicine physiological saline solution and standardize solution is 20ml, carries out Neulized inhalation, treats 1 every day, each 20min.Three groups of patients initially all do not use antitussive medicine, after 2 days as when the scoring of cough integration is 3, add with pentoxyverine citrate sheet 25mg, every day 3 times." cough integration " (coughscore) standards of grading are comply with " 2013MIMS respiratory system disease guide ".
1.2.3 clinical efficacy judges: " the Chinese medical disease Standardization of diagnosis and curative effect " issued with reference to management board of national institute of traditional Chinese medicine, 1. fully recovers: after treatment, dry pharynx is itched, to be coughed and pharyngeal sign all disappears, and is pharyngeally subject to former bringing out after stimulation also without coughing fit; 2. effective: after treatment, dry pharynx is itched, to be coughed and pharyngeal sign all disappears, pharyngeal be subject to former bring out stimulation after can bring out cough; 3. take a turn for the better: the rear dry pharynx for the treatment of is itched, cough and pharyngeal sign obviously alleviates; 4. invalid: the rear dry pharynx for the treatment of is itched, cough and pharyngeal sign is not improved.
1.2.4 statistical analysis: SPSS18.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of patient's antitussive medicine service conditions compare: the antitussive medicine utilization rate in three groups of patient treatment procedure is respectively matched group 59.38%(19/32), liquid group 33.33%(11/33), powder group 32.26%(10/31), difference has statistical significance (χ
2=4.43, P<0.05; χ
2=4.66, P<0.05).Result shows, liquid group, powder composing prescription case when not losing quality of life, can reduce antitussive medicine utilization rate.
2.2 3 groups of Clinical efficacy comparisons: see the following form,
| Group | Number of cases | Recovery from illness | Effective | Take a turn for the better | Invalid | Total effective rate | Cure rate | Cure-remarkable-effectiveness rate |
| Matched group | 32 | 7 | 10 | 11 | 4 | 87.50% | 21.88% | 53.13% |
| Liquid group | 33 | 15 | 12 | 5 | 1 | 96.97% | 45.45% | 81.82% |
| Powder group | 31 | 14 | 11 | 5 | 1 | 96.77% | 45.16% | 80.65% |
After treatment 14d, the total effective rate of liquid group, powder group is higher than matched group, and difference does not have statistical significance (P>0.05).Cure rate and cure-remarkable-effectiveness rate liquid group, powder group are then apparently higher than matched group (cure rate: χ
2=4.03, P<0.05; χ
2=3.84, P<0.05; Cure-remarkable-effectiveness rate: χ
2=6.12, P<0.05; χ
2=5.37, P<0.05).Proved invents the beneficial effect that medicine that two kinds of embodiments obtain has good effect, not easily brings out.
In 2.3 3 months, relapse rate compares: all follow-up of patients three months, and relapse rate is respectively matched group 21.88%(7/32), liquid group 3.03%(1/33), powder group 3.23%(1/31), difference has statistical significance (χ
2=5.35, P<0.05; χ
2=4.94, P<0.05).Result shows, liquid group, powder composing prescription case can effectively reduce larynx and cough relapse rate.
2.4 untoward reaction and toleration: during medication and after drug withdrawal, three groups of patient temperatures, breathing, blood pressure, pulse ratio comparatively there was no significant difference (P > 0.05), also all occur without the obvious heart, liver, kidney untoward reaction and symptoms of asthma.
3. conclusion.
This result of study shows, use the beneficial effect that liquid group of the present invention and powder group have good effect, not easily recur, can obvious relieving cough symptom, and have no adverse reaction, illustrate that medicine prepared by the inventive method has the advantage that curative effect is affirmed, safety is high in treatment laryngeal cough.
Claims (1)
1. a larynx coughs Neulized inhalation powder, preparation method thereof, it is characterized in that, crude drug is precipice Rhizoma Zingiberis Recens, Herba pyrolae japonicae, Fructus Chaenomelis, Caulis Seu Folium Euonymi Fortunei, Gorgon fruit, Fructus Ailanthi, Radix Tricyrtidis pilosae, Radix Cinnamomi porrecti, Resina Liquidambaris, Semen Aesculi, Herba Solani Lyrati, Semen Lini, and preparation method is made up of following steps:
(1) Fructus Chaenomelis, Caulis Seu Folium Euonymi Fortunei, Fructus Ailanthi, precipice Rhizoma Zingiberis Recens, Semen Aesculi, Radix Cinnamomi porrecti, Herba Solani Lyrati, Semen Lini, Resina Liquidambaris coarse powder are extracted volatile oil with vapor distillation respectively, obtain Mixed chaotic sequences and medicinal residues are for subsequent use;
(2) by gained medicinal residues mixing in Herba pyrolae japonicae, Radix Tricyrtidis pilosae, Gorgon fruit and step 1, add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill after filtered through gauze; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, airtight standing 48h, filter, through microporous membrane ultrafiltration after filtrate removing ethanol, filtrate concentrate drying, draws just material;
(3) sprayed into by gained volatile oil in step 1 during step 2 gained just expects, mixing, after pulverizing 100 mesh sieves, sterilizing formed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510803859.0A CN105250614A (en) | 2015-11-20 | 2015-11-20 | Method for preparing throat coughing atomization inhalation powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510803859.0A CN105250614A (en) | 2015-11-20 | 2015-11-20 | Method for preparing throat coughing atomization inhalation powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250614A true CN105250614A (en) | 2016-01-20 |
Family
ID=55090742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510803859.0A Pending CN105250614A (en) | 2015-11-20 | 2015-11-20 | Method for preparing throat coughing atomization inhalation powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105250614A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107969732A (en) * | 2017-12-13 | 2018-05-01 | 江西中烟工业有限责任公司 | Biological composition and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095824A (en) * | 2006-06-29 | 2008-01-02 | 牛全道 | Pharynx-cleaning detoxicating capsule |
| JP2008069113A (en) * | 2006-09-14 | 2008-03-27 | Orient Cancer Therary:Kk | Orally ingestive preparation |
| CN103751508A (en) * | 2014-01-07 | 2014-04-30 | 燕锦虎 | Medicine for oral care in perioperative period and preparation method of medicine |
-
2015
- 2015-11-20 CN CN201510803859.0A patent/CN105250614A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095824A (en) * | 2006-06-29 | 2008-01-02 | 牛全道 | Pharynx-cleaning detoxicating capsule |
| JP2008069113A (en) * | 2006-09-14 | 2008-03-27 | Orient Cancer Therary:Kk | Orally ingestive preparation |
| CN103751508A (en) * | 2014-01-07 | 2014-04-30 | 燕锦虎 | Medicine for oral care in perioperative period and preparation method of medicine |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107969732A (en) * | 2017-12-13 | 2018-05-01 | 江西中烟工业有限责任公司 | Biological composition and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102100856A (en) | Nano traditional Chinese medicine for treating bronchial asthma and preparation technology | |
| CN101138613A (en) | Traditional Chinese medicine for treating acute bronchitis of children | |
| CN102357181B (en) | Traditional Chinese medicine composition for treating cough and preparation method thereof | |
| CN106539908A (en) | A kind of Chinese medicine composition for treating allergic rhinitises and skin allergy | |
| CN105250614A (en) | Method for preparing throat coughing atomization inhalation powder | |
| CN103405722B (en) | Chinese herba preparation for preventing and treating infantile cough | |
| CN105395782A (en) | Preparation method of aerosol inhalation medicine for treating chronic obstructive pulmonary disease | |
| CN101229338B (en) | Heat cough oral liquid | |
| CN105267578A (en) | Atomized liquid for treating laryngeal cough | |
| CN105106601A (en) | Medicinal preparation for treating acute nasopharyngitis | |
| CN105250613A (en) | Medicine for treating chronic obstructive pulmonary disease in stable phase | |
| CN110917271A (en) | Spray for preventing and treating allergic asthma combined allergic rhinitis of children and teenagers | |
| CN104857414A (en) | Medicine composite for treating chronic simple rhinitis | |
| CN104435957A (en) | Preparation method of Chinese medicinal preparation for treating lung abscess | |
| CN104758442B (en) | It is a kind of to prevent and treat compound Chinese medicinal preparation of bronchial astehma and preparation method thereof | |
| CN103948827A (en) | Medicinal composition for aerosol inhalation in preoperative period | |
| CN105362708A (en) | Preparation method of aerosol inhalation medicine used in general anesthesia perioperative period | |
| CN103948826A (en) | Aerosol inhalation solution used in preoperative period and preparation method thereof | |
| CN105311415A (en) | General-anesthesia-operation perioperative period atomization inhaling liquid | |
| CN108143944A (en) | A kind of Chinese medicine composition for treating cold | |
| CN105311224A (en) | Method for preparing children aerosol inhalation medicine | |
| CN105311225A (en) | Atomized liquid for treatment of children noninfectious coughing | |
| CN105031282A (en) | Medicine used for treating infantile hip joint dropsy and preparation method thereof | |
| CN105031586A (en) | Traditional Chinese medicine preparation for treating cough and preparation method thereof | |
| CN105168860A (en) | Traditional Chinese medicine composite for treating infantile asthma and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160120 |