CN105311415A - General-anesthesia-operation perioperative period atomization inhaling liquid - Google Patents
General-anesthesia-operation perioperative period atomization inhaling liquid Download PDFInfo
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- CN105311415A CN105311415A CN201510805771.2A CN201510805771A CN105311415A CN 105311415 A CN105311415 A CN 105311415A CN 201510805771 A CN201510805771 A CN 201510805771A CN 105311415 A CN105311415 A CN 105311415A
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Abstract
The invention discloses a general-anesthesia-operation perioperative-period atomization inhaling liquid. The atomization inhaling liquid aims at achieving the aim of interposing coughing after a general anesthesia operation. The general-anesthesia-operation perioperative-period atomization inhaling liquid is characterized by being prepared from pawpaws, prinsepia uniflora, japanese tripterospermum herbs, eggplant flowers, cipadessa baccifera, dendrobe, spiny raspberry roots, blumea clarkei, wallichiana, bittersweet fruit grass, semen lini and parmelia saxatilis. The clinical trial shows that the general-anesthesia-operation perioperative-period atomization inhaling liquid has the advantages that when coughing after the general anesthesia operation is interposed through the general-anesthesia-operation perioperative-period atomization inhaling liquid, the curative effect is good, safety is high; the general-anesthesia-operation perioperative-period atomization inhaling liquid is worthy of clinical application and popularizing.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of general anesthesia operation peri-operation period Neulized inhalation liquid.
Background technology
In recent years, general anesthesia is day by day perfect along with theory and technology, has been widely used in various breast, abdominal operation.In General anesthesia, patient adopts tracheal intubation to connect artificial respirator assisted ventilation, make patients with respiratory tract normal physiological function impaired, airway mucus mucociliary transport speed (MTR) reduces, and tube drawing back reflection causes respiratory secretions to increase then, mucilage secretion disorder and removing obstacles.Furthermore, intubate is for the stimulation of upper respiratory tract mucosa, and after tube drawing, mucosa presents high sensitiveness, cough easily occurs and waits general anesthesia sequela.In order to solve the problem, there is the postoperative use Neulized inhalation of clinical opinion at present, the medicine great majority used are ambroxol, its pharmacological action is into the secretion of pulmonary surfactant and airway fluids secretion, the mucopolysaccharide azelon of apoplexy due to phlegm is ruptured, promotes that glutinous expectorant dissolves, significantly reduce expectorant viscosity, strengthen bronchial mucosa ciliary movement, promote that sputum is discharged.But because ambroxol is only apophlegmatisant, there is no antitussive effect, postoperative upper respiratory tract mucosa the high quick reflex cough caused can not be controlled.And for general anesthesia operation postoperative patient frequently cough can cause incision pain even otch is hemorrhage.Relate in particular to the operation of respiratory system, then more easily there is post-operative complication in lung tissue, bronchus etc.If but used antitussive medicine, then bronchial secretion could be caused to be detained because of suppression coughre flex, cause pulmonary ventilation not enough, even segmental atelectasis, and then pulmonary infection occurs.
Therefore, how to avoid Balance anesthesia to occur cough symptom, have and can not raise postoperative atelectasis, incidence of pulmonary infection, become the important topic that general anesthesia operation peri-operation period is intervened.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of general anesthesia operation peri-operation period Neulized inhalation liquid, both can reduce post operative cough occurrence probability, reduces patient suffering, can not raise postoperative atelectasis, incidence of pulmonary infection again.
The technical scheme that the present invention solves its technical problem is: a kind of general anesthesia operation peri-operation period Neulized inhalation liquid, is characterized in that being prepared from by the crude drug of following weight proportion: Fructus Chaenomelis 10 ~ 30 parts, Rui core 3 ~ 12 parts, Flos Solani Melongenae 12 ~ 20 parts, Herba Blumeae clarkei 12 ~ 20 parts, sub-sieve Chinese toon 3 ~ 12 parts, Herba Dendrobii 12 ~ 20 parts, Herba Tripterospermi japonici 12 ~ 20 parts, Radix rubi pungentis 12 ~ 20 parts, Salix wallichiana 12 ~ 20 parts, Semen Lini 3 ~ 12 parts, Herba Solani Lyrati 1 ~ 5 part, Parmelia saxatilis Ach. 10 ~ 25 parts.
Wherein said: Fructus Chaenomelis is rosaceous plant chaenomeles lagenaria Chaenomelesspeciosa(Sweet) the dry almost ripe fruit of Nakai.Nature and flavor acid, temperature.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.For arthralgia chiefly caused by damp pathogen contracture, the heavy pain of waist knee joint acid, convulsion of vomiting and diarrhoea, beriberi edema.Rui core is the drying and ripening pit of rosaceous plant Rui core PrinsepiaunifloraBatal. or tingia Folium Prinsepiae Utilis PrinsepiaunifloraBatal.var.serrataRehd..Nature and flavor are sweet, are slightly cold.Return Liver Channel.Function cures mainly: nourishing the liver to improve visual acuity, wind-dispelling heat-dissipating.For conjunctival congestion and swelling pain, red and fester on the palpebral margin, the dark photophobia of order.Flos Solani Melongenae is the flower of plant of Solanaceae eggplant SolanummelongenaL..Sweet in the mouth; Property is put down.Function cures mainly: sore; Pain relieving; Dampness removing.Herba Blumeae clarkei is herb or the root of feverfew Herba Blumeae clarkei BlumeaclarkeiHook.F..Bitter in the mouth; Micro-pungent; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing.Main laryngopharynx swelling and pain; Toothache due to stomach-fire; Diarrhea due to damp-heat; Scrofula tuberculosis; Venom.Sub-sieve Chinese toon, is Meliaceae sub-sieve Chinese toon CipadessabacciferaMiq., is used as medicine with root, leaf.Nature and flavor are bitter, cool.Function cures mainly: dispelling wind to relieve the exterior syndrome, preventing the attack (or recurrence) of malaria.Cure mainly malaria.Herba Dendrobii is the fresh or dry stem of orchid dendrobium loddigesii Rolfe DendrobiumloddigesiiRolfe., Herba Dendrobii oculati DendrobiumfimbriatumHook.var.oculatumHook., HERBA DENDROBII DendrobiumchrysanthumWall., Herba Dendrobii DendrobiumcandidumWall.exLindl. or Dendrobium nobile DendrobiumnobileLindl.; Nature and flavor are sweet, are slightly cold; Return stomach, kidney channel; Merit can reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Herba Tripterospermi japonici is gentianaceae plant high eyebrow Tripterospermum affine Tripterospermumcordatum(Marq.) herb of H.Smith.Acrid in the mouth; Bitter; Cool in nature.Return lung; Liver; Spleen channel.Function cures mainly: wind and heat dispersing; Invigorating spleen to remove dampness; Parasite killing.Main air heat cough; Jaundice; Rheumatic arthralgia; Ascariasis.Radix rubi pungentis, is Rosaceae Radix rubi pungentis RubuswilsoniiDuthie, is used as medicine with root.Bitter, puckery, cool.Function cures mainly: pain relieving, antiinflammatory, regulating menstruation.Salix wallichiana, is Salicaceae Salix wallichiana SalixwallichianaAnders., is used as medicine with root.Pungent, sour, puckery, cool.Function cures mainly: wind dispelling is antipyretic, dehumidifying.Cure mainly rheumatic arthritis.And wind syndrome of head pain can be controlled.Semen Lini is the dry mature seed of flax family (Linaceae) linum Caulis et Folium Lini LinumusitatissimumL..Nature and flavor are sweet, tepor.Function cures mainly: loosening bowel to relieve constipation, nourishing blood to expel wind.For dryness of the intestine constipation; Old man's xerosis cutis Scaling, allergic dermatitis, skin pruritus; Skin infection eczema.Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati SolanumlyratumThunb..Sweet in the mouth; Bitter; Cold in nature.Return liver; Gallbladder; Kidney channel.Merit can clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Parmelia saxatilis Ach., clock emulsion Stakactite dropstone falls apart and spatters as flower person.Nature and flavor are sweet; Temperature; Nontoxic.Function cures mainly: the kidney warming; Bone strengthening; Supporing yang.Main muscles and bones flaccidity is soft; Waist foot cold type of pain; Impotence and premature ejaculation.
In prior art, Balance anesthesia is coughed, if use antitussive medicine, then bronchial secretion can be caused to be detained because of suppression coughre flex, cause pulmonary ventilation not enough, even segmental atelectasis, and then pulmonary infection occurs.But patient frequently cough can cause incision pain even otch is hemorrhage.Antitussive and postoperative Airway Complications become a pair implacable contradiction.
Compared with prior art, the present invention has following characteristics:
1, this prescription does not use antitussive medicine, but reaches the generation of minimizing respiratory mucus by evacuating aqueous vapor, thus reduces the generation of irritable cough;
2, side in Fructus Chaenomelis, Rui core for core, described Fructus Chaenomelis, Rui core are used for Liver Channel disease originally, but inventor's clinical practice Fructus Chaenomelis, this medicine of Rui core then can reduce because mucus stimulates the cough caused to carrying out Neulized inhalation, its mechanism is relevant to dispelling wind aproll, and zoopery also confirms, for open chest surgery rat model, Fructus Chaenomelis, Rui core 2:1 mixing water decocting liquid Neulized inhalation, can reduce the expression of air flue air flue mucin, MUC5AC albumen effectively;
3, after the dilution of Flos Solani Melongenae volatile oil, Neulized inhalation intervenes etherization Wistar rat (anesthesia 1 Neulized inhalation front 3d every day in advance, medicine group is the dilution of Flos Solani Melongenae volatile oil, model group is normal saline), the courageous and upright mucus occurrence probability of postoperative rat mouth and nose (medication group 58.33%, model group 16.67% can be reduced, the two compares P<0.05), its reason may be that Flos Solani Melongenae volatile oil component reduces respiratory mucosa sensitivity;
4, sub-sieve Chinese toon and Herba Blumeae clarkei can strengthen the evacuation effect of Rui core, and its intensity is apparently higher than other diaphoretic medicine;
5, the alkaloid component of Herba Dendrobii has slight central nervous excitation effect and antifatigue effect, is of value to postoperative tranquilizing the mind; Semen Lini coordinate with Herba Dendrobii can the excessive aproll band of gas of antagonism come impairment of body fluid;
6, Herba Tripterospermi japonici volatile oil component is conducive to increasing transdermal absorption factor;
7, Parmelia saxatilis Ach. means using corrigent, prevents medicine excessively cold and cool, and is not easy to post-operative recovery.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Fructus Chaenomelis 20g, Rui core 12g, Flos Solani Melongenae 15g, Herba Blumeae clarkei 15g, sub-sieve Chinese toon 12g, Herba Dendrobii 15g, Herba Tripterospermi japonici 15g, Radix rubi pungentis 15g, Salix wallichiana 15g, Semen Lini 12g, Herba Solani Lyrati 2g, Parmelia saxatilis Ach. 20g
The preparation method of embodiment 1 is: Fructus Chaenomelis, Flos Solani Melongenae, Rui core, Herba Tripterospermi japonici, sub-sieve Chinese toon, Herba Dendrobii, Radix rubi pungentis, Herba Blumeae clarkei, Salix wallichiana, Herba Solani Lyrati, Semen Lini, Parmelia saxatilis Ach. mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, use two layers of filtered through gauze again, gained filtrate 60 DEG C ~ 70 DEG C is concentrated into density 1.15, divide after concentrated solution cooling and add 95% ethanol 3 times, solution ethanol concentration is made to reach 75%, airtight standing 48h, filter, filtrate removing ethanol, uses G
4sintered glass funnel filter is to clear and bright, and sterilizing is preserved.
Embodiment 2, crude drug weight proportion: Fructus Chaenomelis 10 parts, Rui core 3 parts, Flos Solani Melongenae 12 parts, Herba Blumeae clarkei 12 parts, sub-sieve Chinese toon 3 parts, Herba Dendrobii 12 parts, Herba Tripterospermi japonici 12 parts, Radix rubi pungentis 12 parts, Salix wallichiana 12 parts, Semen Lini 3 parts, Herba Solani Lyrati 1 part, Parmelia saxatilis Ach. 10 parts.
Embodiment 3, crude drug weight proportion: Fructus Chaenomelis 20 parts, Rui core 12 parts, Flos Solani Melongenae 15 parts, Herba Blumeae clarkei 15 parts, sub-sieve Chinese toon 12 parts, Herba Dendrobii 15 parts, Herba Tripterospermi japonici 15 parts, Radix rubi pungentis 15 parts, Salix wallichiana 15 parts, Semen Lini 12 parts, Herba Solani Lyrati 2 parts, Parmelia saxatilis Ach. 20 parts
Embodiment 4, crude drug weight proportion: Fructus Chaenomelis 30 parts, Rui core 12 parts, Flos Solani Melongenae 20 parts, Herba Blumeae clarkei 20 parts, sub-sieve Chinese toon 12 parts, Herba Dendrobii 20 parts, Herba Tripterospermi japonici 20 parts, Radix rubi pungentis 20 parts, Salix wallichiana 20 parts, Semen Lini 12 parts, Herba Solani Lyrati 5 parts, Parmelia saxatilis Ach. 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Fructus Chaenomelis, Rui core, Flos Solani Melongenae, sub-sieve Chinese toon, Herba Dendrobii, Herba Solani Lyrati, Herba Tripterospermi japonici, Semen Lini coarse powder are extracted volatile oil with vapor distillation respectively, obtain Mixed chaotic sequences and medicinal residues are for subsequent use;
(2) by gained medicinal residues mixing in Radix rubi pungentis, Salix wallichiana, Herba Blumeae clarkei, Parmelia saxatilis Ach. and step 1, add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill after filtered through gauze; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, airtight standing 48h, filter, through microporous membrane ultrafiltration after filtrate removing ethanol, filtrate concentrate drying, draws just material;
(3) sprayed into by gained volatile oil in step 1 during step 2 gained just expects, mixing, after pulverizing 100 mesh sieves, sterilizing formed.
The efficient combination of said medicine, coordinates mutually, effectively reach the effect played and intervene general anesthesia operation post operative cough, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: intend in May, 2011 ~ in May, 2013 in descending adult patients 112 example of choosing date for operation of general anesthesia (intubate inhalation anesthesia), wherein male patient is 69 examples, and women's sufferer is 43 examples, 18 ~ 69 years old age, 47.4 ± 5.5 years old mean age.Surgery location is respectively cardiothoracic surgery 71 example, abdominal operation 34 example, limb operation 7 example.Get rid of heart and lung diseases, have smoking history, respiratory system allergies, asthma medical history or chronic laryngopharyngeal diseases history, be in acute stage respiratory tract disease, the respiratory tract infection in nearly 2 weeks and other can affect the situation of lung ventilation function.
1.1.2 divide into groups: be divided into matched group 37 example, liquid dosage form group 38 example and powder formulation group 37 example.Compare in sex, age, modus operandi etc. before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 medicament selection: matched group adopts Mucosolvan injection, and 15mg is each; Liquid dosage form group is with the embodiment of the present invention 1 gained Neulized inhalation liquid, and each using dosage is equivalent to crude drug amount 40g; Powder formulation group is with gained sterile powder in the embodiment of the present invention 3, and each using dosage is equivalent to crude drug amount 40g.
1.2.2 aerosol inhalation method: patient all starts to adopt atomization inspiration treatment in preoperative 3d: by medicine physiological saline solution and standardize solution is 20mL, treats 2 every day, each 15 ~ 20min.All take conventional therapy and nursing after all operation in patients, comprise antibiotic use.Adopt above-mentioned aerosol inhalation method and dosage to carry out treatment 5d simultaneously.
1.2.3 observation index: postoperative 24 hours cough integrations, a situation arises and medication related reactions for postoperative 5d pulmonary complication.Described " cough integration " (coughscore), standards of grading are comply with " 2013MIMS respiratory system disease guide ".
1.2.4 statistical analysis: SPSS18.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of postoperative 24 hours cough integral contrasts: see the following form,
| Group | Number of cases | 0 point | 1 point | 2 points | 3 points |
| Matched group | 37 | 11 | 8 | 16 | 2 |
| Liquid dosage form group | 38 | 20 | 10 | 7 | 1 |
| Powder formulation group | 37 | 21 | 9 | 5 | 2 |
Result shows, and liquid dosage form group, powder formulation group cough incidence (47.37%, 43.24%) are starkly lower than matched group (70.27%), and difference has statistical significance (χ
2=4.05, P>0.05; χ
2=5.51, P>0.05), middle severe cough (integration>=2 point) incidence rate, liquid dosage form group, powder formulation group cough incidence (21.05%, 18.92%) are starkly lower than matched group (48.65%), and difference has statistical significance (χ
2=5.07, P>0.05; χ
2=7.31, P>0.01).
2.1 3 groups of postoperative 5d air flue related complications compare: see the following form,
| Group | Number of cases | Pulmonary atelectasis | Pulmonary infection | Acute ventilatory dysfunction | Asthma |
| Matched group | 37 | 2 | 2 | 1 | 0 |
| Liquid dosage form group | 38 | 1 | 1 | 1 | 0 |
| Powder formulation group | 37 | 1 | 1 | 0 | 0 |
After treating 1 course for the treatment of, comparative result display (matched group 13.51%, liquid dosage form group 7.89%, powder formulation group 5.41%) between Airway Complications incidence rate group, no significant difference (χ
2=0.62, P>0.05; χ
2=1.42, P>0.05), the medicine that confirmation embodiment of the present invention obtains can't increase the generation of the postoperative air flue related complication of general anesthesia operation.
2.2 untoward reaction and toleration: during medication, three groups of patient temperatures, breathing, blood pressure, pulse ratio comparatively there was no significant difference (P > 0.05), also all occur without the obvious heart, liver, kidney untoward reaction and symptoms of asthma.
3. conclusion.
This result of study shows, use liquid dosage form group of the present invention and powder formulation group effectively can reduce Balance anesthesia cough incidence and symptom degree, and the incidence rate of postoperative Airway Complications compared with matched group without notable statistics difference, also have no adverse reaction, illustrate that medicine prepared by the inventive method has the advantage that curative effect is affirmed, safety is high in the prevention of general anesthesia operation post operative cough.
Claims (1)
1. a general anesthesia operation peri-operation period Neulized inhalation liquid, is characterized in that being prepared from by the crude drug of following weight proportion: Fructus Chaenomelis 10 ~ 30 parts, Rui core 3 ~ 12 parts, sub-sieve Chinese toon 3 ~ 12 parts, Herba Dendrobii 12 ~ 20 parts, Radix rubi pungentis 12 ~ 20 parts, Flos Solani Melongenae 12 ~ 20 parts, Herba Blumeae clarkei 12 ~ 20 parts, Salix wallichiana 12 ~ 20 parts, Herba Tripterospermi japonici 12 ~ 20 parts, Semen Lini 3 ~ 12 parts, Herba Solani Lyrati 1 ~ 5 part, Parmelia saxatilis Ach. 10 ~ 25 parts.
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Cited By (1)
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Application publication date: 20160210 |