CN103920056B - Aerosol inhalation liquid for preventing postoperative tracheospasm and preparation method thereof - Google Patents
Aerosol inhalation liquid for preventing postoperative tracheospasm and preparation method thereof Download PDFInfo
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Abstract
The invention discloses aerosol inhalation liquid for preventing postoperative tracheospasm and a preparation method thereof to have the preventive effect of reducing operative lung related complications. The preparation method is characterized by comprising the following steps: (1) distilling coarse powder of piny flower, jasminum grandiflorum, shiraia bambusicola, root of prinos-like salacia, bark of himalayan coralbean, tetrapanax papyriferum, welsh-onion stalk and fruit of Japanese cinnamon respectively with water steam to extract volatile oil, and collecting and mixing dregs of a decoction for later use; (2) uniformly mixing stem of climbing entada, ivy glorybind herb root, bulbophyllum inconspicuum maxim, eulaliopsis binata and the dregs of the decoction obtained in the step 1, adding five times amount of water to decoct the mixture twice, one hour each time, merging the decoctions and standing, then adding 95% ethanol of 3-4 times of liquid to the decoctions, standing for 15 minutes, then centrifuging the solution at a speed of 3000rpm for 20 minutes, and taking and spray-drying the supernatant, thus obtaining an initial material; (3) spraying the volatile oil obtained in the step 1 into the initial material obtained in the step 2, mixing the volatile oil with the initial material uniformly, grinding the mixture, sieving the powder with a 100-mesh sieve, and subpackaging the powder, thus obtaining the aerosol inhalation liquid. Clinical experiments prove that the aerosol inhalation liquid has the characteristics of good curative effects and relatively high safety when used for protecting the lung in the perioperative period, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines is and in particular to a kind of Neulized inhalation liquid of prevention Post operation tracheospasm and preparation method thereof.
Background technology
Surgery During Perioperative Period lung preversation, refers on one's own initiative a variety of causes to be caused, the prevention and treatment of imminent injury of lung, to safeguard Pulmonary Function, promotes early recovery.
Postoperative pulmonary complications incidence rate highest is nosocomial pneumonia, but infection appropriate measures in recent years, efficiently control its mortality rate.Bronchospasm is one of obstruction of pulmonary ventilation of peri-operation period most serious, and common surgical procedures incidence rate is about 0.6% ~ 0.8%, and the incidence rate of Thoracic surgery is higher.And for having chronic obstructive pulmonary disease (COPD), asthma patients with history, the incidence rate of peri-operation period bronchospasm increases up to 10%, especially thoracic operation is up to 39.5%.Once there is serious bronchospasm in patient, especially in stage of surgery, such as process not in time, can cause severe depletion of oxygen and carbon dioxide accumulation, or even threat to life.In operation process, the operation such as Anesthesia medicine and tracheal intubation all can induce the generation of bronchospasm, and its mortality rate is up to 70%.
But bronchospasm the disease of non-orphaned, the existing pathophysiological change of air flue before this, in order to describe this pathological process, 2009《The common recognition of thoracic surgery peri-operation period lung preversation》Propose " high high-impedance state of reactivity " concept.The high high-impedance state of reactivity refers to：There is high risk factor（With）Patient, vagal tone increases, Airway inflammatory response leads to airway hyperreactivity, airway constriction and airway resistance increase, and causes a series of peri-operation period pulmonary complications.High high-impedance state of reactivity is the quantitative change process of a progressively evolution, in any one stage of this process, all can cause bronchospasm under risk factor effect.Even if not inducing bronchospasm, also can cause flow limitation, sputum inadequate drainage, leading to the peri-operation period pulmonary complications such as pulmonary atelectasis, pulmonary edema, pneumonia, respiratory failure or even adult respiratory distress syndrome (ARDS).Wherein, airway resistance is increased is the core of high high-impedance state of reactivity, is also the one of the main reasons causing peri-operation period pulmonary complication.
Content of the invention
The technical assignment of the present invention is for above the deficiencies in the prior art, provides Neulized inhalation liquid of prevention Post operation tracheospasm of a kind of curative effect affirmative and Small side effects and preparation method thereof.
The technical scheme that the present invention solves its technical problem is：The lung preversation medicine that a kind of peri-operation period uses is it is characterised in that be prepared from by the crude drug of following weight proportion：10 ~ 30 parts of Flos pini, 6 ~ 12 parts of Radix salaciae prinoidiss, 3 ~ 10 parts of Flos jasmini, 6 ~ 12 parts of Caulis Entadae, 3 ~ 10 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), 6 ~ 12 parts of Herba Bulbophylli inconspicui, 6 ~ 12 parts of Concretio silicea Bambusae seu schizostachyi, 6 ~ 12 parts of Fructus Gastrodiae, 6 ~ 12 parts of Cortex erythrinae, 1 ~ 5 part of Rhizoma eulatiopsis binatae, 3 ~ 10 parts of Fructus cinnamomi immaturus, 10 ~ 25 parts of Bulbus Allii Fistulosi.
Chinese medicine of the present invention can be prepared from as follows：
（1）Flos pini, Flos jasmini, Concretio silicea Bambusae seu schizostachyi, Radix salaciae prinoidiss, Cortex erythrinae, Fructus Gastrodiae, Bulbus Allii Fistulosi, Fructus cinnamomi immaturus coarse powder are extracted volatile oil with vapor distillation respectively, and collects medicinal residues mixing for standby use；
（2）In Caulis Entadae, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Bulbophylli inconspicui, Rhizoma eulatiopsis binatae and step 1, gained medicinal residues mix plus 5 times of water yields, add water to cook 2 times, 1 hour every time, collecting decoction, standing；Then add the 95% of 3 ~ 4 times of medicinal liquids ethanol toward in decocting liquid, stand 15 minutes, be then centrifuged 20 minutes with 3000rpm, take supernatant, be spray-dried, draw just material；
（3）In expecting at the beginning of gained volatile oil sprays into step 2 gained in step 1, mix, pulverize, cross 100 mesh sieves, subpackage forms.
Wherein said：Flos pini, is pinaceae plant Pinus massoniana Lamb Pinus massoniana Lamb., Pinus tabulaeformis tabulaeformis Carr., Pinus densiflora Pinus densiflora Sieb.et
The pollen of Zucc, Pollen pini thunbergii Pinus thunbergii Parl etc..Nature and flavor are sweet；Warm in nature.Return liver；Stomach.Work(can wind-dispelling；QI invigorating；Removing dampness；Hemostasis.
Radix salaciae prinoidiss, are the root of Hippocrateaceae plant Salacia prinoides (Willd.) DC. Salacia prinoides (Willd.) DC..Nature and flavor are puckery；Temperature.Return liver；Kidney channel.Work(can dispelling wind and removing obstruction in the collateral；Restore menstrual flow and invigorate blood circulation.
Flos jasmini, is Oleaceae plants Flos jasmini Jasminu, the dry flower of grandiflorum L..Nature and flavor slight bitter；Mild-natured.Return liver warp.Work(can soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.
Caulis Entadae, is stem, the leaf of moraceae plants Radix Pachyrhizi Erosi banyan Ficus tikoua Bur..Nature and flavor bitter in the mouth；Cold in nature.Work(can clearing away heat-damp and promoting diuresis；Promoting blood circulation to remove obstruction in the collateral；Removing toxic substances and promoting subsidence of swelling.
Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), is herb or the root of dicotyledon scammonia section plant DAWANHUA Calystegia hederacea Wall..Property sweet and slightly bitter taste；Flat.Return liver；Kidney channel.Work(can spleen invigorating；Dampness removing；Regulating menstruation.
Herba Bulbophylli inconspicui, is orchid family Bulbophyllum platymiscium Herba Bulbophylli inconspicui Bulbophyllum inconspicuum Maxim., with all herbal medicine.Nature and flavor are sweet, light, cool.Work(can nourishing YIN and clearing away heat, preventing phlegm from forming and stopping coughing.
Concretio silicea Bambusae seu schizostachyi, is that Mycophyta Ascomycetes Rou Zuo section Concretio silicea Bambusae seu schizostachyi belongs to Fungus Zhuhuang Shiraia bambusicola Henn., is used as medicine with Stroma.Nature and flavor are light, put down.Work(can expelling wind and removing dampness, promoting blood circulation relax warp, cough-relieving.
Fructus Gastrodiae, is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth；Cold in nature.Work(can qi-restoratives subduing the wind syndrome.
Cortex erythrinae, is bark or the root bark of pulse family Erythrinae Arborescentiss Erythrina indica Lam..Nature and flavor are bitter, put down.Return liver and kidney channel.Work(can wind-damp dispelling, channels sootheing and network vessel quickening.Wind-damp dispelling, the meridian dredging, parasite killing.
Rhizoma eulatiopsis binatae, is the tender rhizome that grass intends Jin Mao.Work(can circulation of qi promoting removing blood stasis.
Fructus cinnamomi immaturus, are that the young okra fruit of canella Cortex Cinnamomi is real.Gas fragrance, taste is micro- sweet.Nature and flavor Wen Xingan, returns stomach.Work(can warming spleen and stomach for dispelling cold.
Bulbus Allii Fistulosi, is the cauloid of Liliaceae allium Herba Alii fistulosi, and work(can be delivered and activate yang, and detoxify parasite killing.
Composition principle：The pathologic basis of bronchospasm are " high high-impedance states of reactivity ", namely there is high risk factor（With）Patient, vagal tone increases, Airway inflammatory response leads to airway hyperreactivity, airway constriction and airway resistance increase, and causes a series of peri-operation period pulmonary complications.Wherein, airway resistance is increased is the core of high high-impedance state of reactivity, is also the one of the main reasons causing peri-operation period pulmonary complication.Do not have " airway resistance is increased " this concept in traditional medicine, inventor's clinical experience gained it is believed that " airway resistance is increased " its be pathogen be detained in lung network one kind performance.But, this " airway resistance is increased " is only the sign that symptom occurs, not originate factor, its induction basis is a kind of high reactive state producing under " high risk factor ", and the result of generation " airway resistance is increased " for common people, stress be caused, but there is patient's network QI-insufficiency of chronic obstructive pulmonary disease and asthma medical history, QI and blood in network stress be played not all right, then body fluid stays to gather and does not dissipate, and then becomes bronchospasm.Therefore its treatment, answer QI invigorating, dredging collateral to go forward side by side.
Compared with prior art, the invention has the characteristics that：
1st, prescription is unique：Flos pini, Radix salaciae prinoidiss are taken to be monarch in side, gas defended in fact by described Flos pini, Radix salaciae prinoidiss walk nutrient blood, the two cooperation, jointly reach the effect of activating qi and collateral.From Flos pini rather than ginseng stilbene etc QI invigorating medicine the reason be：Flos pini invigorating middle warmer is walked, and has the work(that row defends point, contributes to gain, dissipates the network gas that lung is defended；For chronic obstructive pulmonary disease rat open chest surgery model, Flos pini：Radix salaciae prinoidiss=2：Mixing decocting liquid under 1 ratio is compared with blank control group, and airway resistance substantially reduces, minute ventilation volume increases；
2nd, Flos jasmini, Caulis Entadae, Herba Bulbophylli inconspicui, Concretio silicea Bambusae seu schizostachyi is taken to be minister in side, Caulis Entadae, Concretio silicea Bambusae seu schizostachyi dampness removing promoting blood circulation to remove obstruction in the collateral, the minimizing of secretions in favourable Rhizoma Atractylodis Macrocephalae；Herba Bulbophylli inconspicui assists Flos pini YIN nourishing, and has clears phlegm, especially suitable chronic obstructive pulmonary disease patients with history.And the spasm that Flos jasmini can be caused with antagonism acetylcholine, there is Bronchial Relaxation effect；
3rd, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) dampness removing；Fructus Gastrodiae qi-restoratives；Cortex erythrinae dredging collateral is to alleviate pleura symptom；Rhizoma eulatiopsis binatae circulation of qi promoting removing blood stasis；Fructus cinnamomi immaturus metaplasia yang-energy in the heart；
4th, using corrigent：Fructus Gastrodiae also has the work(of using corrigent, prevents postoperative blood deficiency and circulation of qi promoting is too, absurd raw endogenous wind；
5th, Bulbus Allii Fistulosi is activated yang, and row is between the exterior and the interior it is adaptable to preoperative have chronic obstructive pulmonary disease patients with history；
6th, medicine material consumption of the present invention is groped to summarize to draw through inventor in a large number, and each raw material dosage is all to have preferable curative effect in following weight parts scope.
Specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion：20 parts of Flos pini, 10 parts of Radix salaciae prinoidiss, 6 parts of Flos jasmini, 10 parts of Caulis Entadae, 6 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), 10 parts of Herba Bulbophylli inconspicui, 10 parts of Concretio silicea Bambusae seu schizostachyi, 10 parts of Fructus Gastrodiae, 10 parts of Cortex erythrinae, 2 parts of Rhizoma eulatiopsis binatae, 6 parts of Fructus cinnamomi immaturus, 20 parts of Bulbus Allii Fistulosi.
The preparation method of embodiment 1 is：By Flos pini（Decoct a drug wrapped）, Radix salaciae prinoidiss, Flos jasmini, Caulis Entadae, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Bulbophylli inconspicui, Concretio silicea Bambusae seu schizostachyi, Fructus Gastrodiae, Cortex erythrinae, Rhizoma eulatiopsis binatae, Fructus cinnamomi immaturus, Bulbus Allii Fistulosi mixing and water adding decoct, filtrate is taken after 30 minutes, medicinal residues add water after continuation decocts 20 minutes and take filtrate, and filtrate merges twice, is divided into two parts and takes in the morning and evening.
Embodiment 2, crude drug weight proportion：10 parts of Flos pini, 6 parts of Radix salaciae prinoidiss, 3 parts of Flos jasmini, 6 parts of Caulis Entadae, 3 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), 6 parts of Herba Bulbophylli inconspicui, 6 parts of Concretio silicea Bambusae seu schizostachyi, 6 parts of Fructus Gastrodiae, 6 parts of Cortex erythrinae, 1 part of Rhizoma eulatiopsis binatae, 3 parts of Fructus cinnamomi immaturus, 10 parts of Bulbus Allii Fistulosi.
Embodiment 3, crude drug weight proportion：20 parts of Flos pini, 10 parts of Radix salaciae prinoidiss, 6 parts of Flos jasmini, 10 parts of Caulis Entadae, 6 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), 10 parts of Herba Bulbophylli inconspicui, 10 parts of Concretio silicea Bambusae seu schizostachyi, 10 parts of Fructus Gastrodiae, 10 parts of Cortex erythrinae, 2 parts of Rhizoma eulatiopsis binatae, 6 parts of Fructus cinnamomi immaturus, 20 parts of Bulbus Allii Fistulosi.
Embodiment 4, crude drug weight proportion：30 parts of Flos pini, 12 parts of Radix salaciae prinoidiss, 10 parts of Flos jasmini, 12 parts of Caulis Entadae, 10 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), 12 parts of Herba Bulbophylli inconspicui, 12 parts of Concretio silicea Bambusae seu schizostachyi, 12 parts of Fructus Gastrodiae, 12 parts of Cortex erythrinae, 5 parts of Rhizoma eulatiopsis binatae, 10 parts of Fructus cinnamomi immaturus, 25 parts of Bulbus Allii Fistulosi.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from as follows：
（1）Flos pini, Flos jasmini, Concretio silicea Bambusae seu schizostachyi, Radix salaciae prinoidiss, Cortex erythrinae, Fructus Gastrodiae, Bulbus Allii Fistulosi, Fructus cinnamomi immaturus coarse powder are extracted volatile oil with vapor distillation respectively, and collects medicinal residues mixing for standby use；
（2）In Caulis Entadae, Herba Bulbophylli inconspicui, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Rhizoma eulatiopsis binatae and step 1, gained medicinal residues mix plus 5 times of water yields, add water to cook 2 times, 1 hour every time, collecting decoction, standing；Then add the 95% of 3 ~ 4 times of medicinal liquids ethanol toward in decocting liquid, stand 15 minutes, be then centrifuged 20 minutes with 3000rpm, take supernatant, be spray-dried, draw just material；
（3）In expecting at the beginning of gained volatile oil sprays into step 2 gained in step 1, mix, pulverize, cross 100 mesh sieves, subpackage forms.
During use, take 10g Neulized inhalation medication powder, add 50 DEG C of normal saline or water purification 40ml, carry out atomizing face mask suction.2 times a day.
The efficient combination of said medicine, coordinates mutually, activating qi and collateral, effectively reaches the purpose of peri-operation period lung preversation, and side effect is less.The above results fully prove, relevant information is as follows for clinical data.
1 object and method.
1.1 object.
1.1.1 case selection：In June, 2012 ~ 2014 year January operation patients and previously have high-risk, slight or moderate chronic obstructive pulmonary disease patients with history 98, wherein man 69, female 29；Age 22 ~ 78（45.77±9.31）Year.The past smoking history>2 years patients 48, asthma medical history 14.Art formula：Pulmonary surgery 48, operation on chest wall 22, esophageal surgery 18, repair of diaphragmatic hernia 5, other 5.
1.1.2 packet：Patient is randomly divided into matched group 32, decoction group 31 and atomization group 35.Three groups of patients compare in sex, age, art formula, medical history, no significant difference（P>0.05）, there is comparability.
1.1.3 chronic obstructive pulmonary disease (COPD) was divided into for five phases according to symptom and FEV1/FVC：High-risk：Moderate muscle power has symptom, normal pulmonary function；Slightly：Slightly muscle power has symptom, FEV1 ＞ 80%；Moderate：Light activity has symptom, 50% ＜ FEV1 ＜ 80%；Severe：Asymptomatic during rest, slightly dynamic have symptom, 30% ＜ FEV1 ＜ 50%；Severity：Exhale and decline or decline in the heart right side, FEV1 ＜ 30%.
1.2 method.
1.2.1 Therapeutic Method：Matched group adopts conventional thoracic surgery preoperative care, including cleaning respiratory tract and expectoration., respectively on the basis of matched group, first three sky of Rhizoma Atractylodis Macrocephalae starts following intervention stratege for decoction group and atomization group：Decoction group with gained decoction oral in the embodiment of the present invention 1,2 times/d；Atomization group, to add with the proportioning raw materials in the embodiment of the present invention 3 and preparation method gained Neulized inhalation medication powder 10g, adds 50 DEG C of normal saline or water purification 40ml, mixes, carries out atomizing face mask suction.2 times a day.All cases are preoperative to be avoided taking anticholinergic agentses.
1.2.2 observation index：Respiratory system related complication situation；Hospital stayss.
1.2.3 statistical analysis：SPSS 13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ2Inspection.
2 results
2.1 3 groups of respiratory system related complication situations compare：See table,
| Group | Number of cases | Pulmonary infection | Pulmonary atelectasis | Bronchospasm | Other |
| Matched group | 32 | 11 | 3 | 11 | 1 |
| Decoction group | 31 | 6 | 1 | 4 | 1 |
| Atomization group | 35 | 7 | 1 | 4 | 0 |
Pulmonary infection and pulmonary atelectasis incidence rate, decoction group and atomization group are less than matched group, but difference is not statistically significant.
Decoction group and atomization group bronchospasm incidence rate are all significantly lower than matched group（χ2=4.00, P<0.05；χ2=4.53, P<0.05）.
2.2 3 groups of hospital stayss compare：The matched group hospital stayss are 18.16 ± 6.11d, and decoction group is 13.51 ± 4.45d, and atomization group is 14.01 ± 4.74d, and decoction group and atomization group are significantly shorter than matched group（P<0.05）.
A situation arises for 2.3 3 groups of Patient drug's related reactions：Three groups all obvious medicine related reactions.
3. conclusion.
This result of study shows; decoction group and atomization group using the present invention can effectively reduce postoperative bronchospasm incidence rate; and the hospital stayss are less than matched group, illustrate that the pharmaceutical composition of the inventive method preparation has the advantage that curative effect is affirmed, safety is higher in terms of peri-operation period lung preversation.
Claims (2)
1. a kind of preparation method of the Neulized inhalation liquid of prevention Post operation tracheospasm, it is characterized in that, crude drug is 10 ~ 30 parts of Flos pini, 6 ~ 12 parts of Radix salaciae prinoidiss, 3 ~ 10 parts of Flos jasmini, 6 ~ 12 parts of Caulis Entadae, 3 ~ 10 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), 6 ~ 12 parts of Herba Bulbophylli inconspicui, 6 ~ 12 parts of Concretio silicea Bambusae seu schizostachyi, 6 ~ 12 parts of Fructus Gastrodiae, 6 ~ 12 parts of Cortex erythrinae, 1 ~ 5 part of Rhizoma eulatiopsis binatae, 3 ~ 10 parts of Fructus cinnamomi immaturus, 10 ~ 25 parts of Bulbus Allii Fistulosi；It is made up of following steps：
（1）Flos pini, Flos jasmini, Concretio silicea Bambusae seu schizostachyi, Radix salaciae prinoidiss, Cortex erythrinae, Fructus Gastrodiae, Bulbus Allii Fistulosi, Fructus cinnamomi immaturus coarse powder are extracted volatile oil with vapor distillation respectively, and collects medicinal residues mixing for standby use；
（2）In Caulis Entadae, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Bulbophylli inconspicui, Rhizoma eulatiopsis binatae and step 1, gained medicinal residues mix plus 5 times of water yields, add water to cook 2 times, 1 hour every time, collecting decoction, standing；Then add the 95% of 3 ~ 4 times of medicinal liquids ethanol toward in decocting liquid, stand 15 minutes, after centrifugation, take supernatant, be spray-dried, draw just material；
（3）In expecting at the beginning of gained volatile oil sprays into step 2 gained in step 1, mix, pulverize, cross 100 mesh sieves, subpackage forms.
2. according to claim 1 a kind of prevention Post operation tracheospasm Neulized inhalation liquid preparation method it is characterised in that its parameter of noncentricity be 3000rpm, 20 minutes.
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| WO2006004658A2 (en) * | 2004-06-29 | 2006-01-12 | Amgen Inc. | Furanopyrimidines |
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| CN103656325A (en) * | 2013-12-31 | 2014-03-26 | 张翠荣 | Incision nursing substance for treating post-operation incision sensory discomfort |
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