CN105311225A - Atomized liquid for treatment of children noninfectious coughing - Google Patents
Atomized liquid for treatment of children noninfectious coughing Download PDFInfo
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Abstract
The invention discloses atomized liquid for treatment of children noninfectious coughing to treat children noninfectious coughing. The atomized liquid is characterized by being prepared from pterospermum hetero-phyllum hance, euphorbia maculata, fresh gorgon euryale seeds, wintergreen, fruits of ailanthus altissima swingle, pseudodrynaria coronans, cinnamomum camphora, artemisia argyi, beautiful sweetgum resin, semen aesculi, solanum lyratum thumb and flax seeds. Clinical experiments prove that the atomized liquid for treatment of children noninfectious coughing has the advantages of being good in curative effect and high in safety performance.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to the non-infectious treatment of cough atomized liquid of a kind of child.
Background technology
All explicitly point out in " children chronic cough Clinics and Practices guide (revision in 2013) " and " 2013MIMS respiratory system disease guide ": cough is divided into infectious cough and non-infectious cough by the cause of disease (or cause of disease), so-called non-infectious cough has cough, pharyngeal malaise symptoms, but not there is respiratory tract infection, blood routine examination display leukocyte is not high, cough presents the feature of persistence, zest, paroxysmal cough more, and pulmonary's texture does not have substantial variation.This non-infectious cough mostly is non-infectious factor and produces stimulation to respiratory tract and cause cough, and antibiotic therapy is generally inoperative.Due to the change of living environment, the ratio of non-infectious cough is more and more higher, and haze, smog all can bring out non-infectious cough.The pathophysiological mechanism of non-infectious cough is still not very clear, generally believe neural with upper respiratory tract high quick relevant in recent years, and the pathologic basis of the neural Gao Min of upper respiratory tract mostly is bottleneck throat retropharyneal folliculosis, or with mucous gland pipe choking under larynx mucosa, mucus retention, excites high air flue to react.
The cough of current western medical treatment mostly is antibiotic anti-inflammatory treatment, coordinates antitussive medicine, but due to the factor of starting not be respiratory tract infection, therefore use effects of antibiotics bad, and due to abuse of antibiotics, easily bring out enteric flora disturbance.And the use of antitussive medicine, explicitly point out in the cough diagnosis and treatment guide that American Thoracic doctors'associations (ACCP) 2014 promulgate: antitussive and other OTC (over-the-counter) cough medicines should do not used to chronic cough infant (particularly young infant), because these medicines do not have clear and definite curative effect, and with significant complication and case fatality rate.Meanwhile, U.S.'s department of pediatrics association is also unequivocally opposed to and treats the children cough of any type with codeine and dextromethorphan.
Therefore, the non-infectious treatment of cough of current child mainly relies on Chinese medicine, existing pathogenesis complys with exopathogen invasion and attack, internal organs virtual loss etc. more, use is relieved inflammation or internal heat (lung-fire, heart-fire, stomach-fire), medicine that is nourshing Yin and drynsessmoistening prescription, smooth throat to stop cough is treated, but in fact due to " cough caused by dryness " that the non-infectious children with cough of Among Children is not simple, dry pharynx, itching throat, cold air, speak etc. can cause cough, the pathology even had is shown as that mucus retention under larynx mucosa causes, and can not obtain good effect because " relieve inflammation or internal heat and moisturize " simply.Use antitussive medicine, sometimes central antitussive effect can be passed through in a short time, reduce coughre flex, reach antitussive object, but infant is recurrent exerbation in a week to two weeks often, its reason is that the mucosa infection swallowing rear wall does not improve, after antitussive medicine event resolves, coughre flex is replied, and symptom is staged a comeback.At present clinical also have use Neulized inhalation to carry out treating, but current inhalable aerosol drug is lower respiratory tract mainly for object, for bottleneck throat mucosa, the bad local application's effect that causes of adhesive force due to inhalable aerosol drug is bad, but use mucosa attachment adjuvant, probably strengthen again throat membranes to stimulate, strengthen cough.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, a kind of child is provided to use inhalable aerosol drug preparation method, by using this inhalable aerosol drug both can alleviate the non-infectious cough symptom of child, reducing infants' pain, effectively can reduce recurrence again.
The technical scheme that the present invention solves its technical problem is: a kind of child uses inhalable aerosol drug preparation method, it is characterized in that being prepared from by the crude drug of following weight proportion: precipice Rhizoma Zingiberis Recens 12 ~ 20 parts, Herba pyrolae japonicae 12 ~ 20 parts, Folium Pterospermi Heterophylli 10 ~ 33 parts, Herba Euphorbiae supinae 3 ~ 12 parts, Semen Aesculi 12 ~ 20 parts, Radix Cinnamomi porrecti 12 ~ 20 parts, Herba Acroptili repentis 12 ~ 20 parts, Fructus Ailanthi 3 ~ 12 parts, Semen Lini 3 ~ 12 parts, Resina Liquidambaris 10 ~ 25 parts, 12 ~ 20 parts, Gorgon fruit, Herba Solani Lyrati 1 ~ 5 part.
Chinese medicine of the present invention can be prepared from by following method:
(1) Folium Pterospermi Heterophylli, Herba Euphorbiae supinae, Fructus Ailanthi, Herba Acroptili repentis, Radix Cinnamomi porrecti, Herba Solani Lyrati, Semen Lini coarse powder are extracted volatile oil with vapor distillation respectively, obtain Mixed chaotic sequences and medicinal residues are for subsequent use;
(2) by gained medicinal residues mixing in precipice Rhizoma Zingiberis Recens, Herba pyrolae japonicae, Semen Aesculi, Gorgon fruit, Resina Liquidambaris and step 1, add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill after filtered through gauze; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, airtight standing 48h, filter, through microporous membrane ultrafiltration after filtrate removing ethanol, filtrate concentrate drying, draws just material;
(3) sprayed into by gained volatile oil in step 1 during step 2 gained just expects, mixing, after pulverizing 100 mesh sieves, sterilizing formed.
Wherein said: Herba pyrolae japonicae is the dry herb of Pyrolaceae plant Herba pyrolae japonicae PyrolacallianthaH.Andres or ovum leaf Herba pyrolae japonicae PyroladecorataH.Andres; Nature and flavor are sweet, bitter, temperature; Return liver, kidney channel; Merit can tonify deficiency, kidney tonifying, expelling wind and removing dampness, promoting blood flow to regulate menstruation; Precipice Rhizoma Zingiberis Recens is fern Polypodiaceae precipice ginger precipice Rhizoma Zingiberis Recens Pseudodrynariacoronans(Wall.) Ching, is used as medicine with root stock.Nature and flavor are bitter, micro-puckery, temperature.Function cures mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.Folium Pterospermi Heterophylli is the leaf of Sterculiaceae plant Folium potentillae velutinae (Radix Potentillae Fulgentis) tree PterospermumheterophyllumHance or Radix Pterospermi lanceaefolii PterospermumlanceaefoliumRoxb..Nature and flavor are sweet; Light; Tepor.Return liver; Spleen channel.Function cures mainly: promoting blood circulation and hemostasis.Herba Euphorbiae supinae is the herb of euphorbia plant Herba Euphorbiae supinae.Nature and flavor are pungent, flat.Function cures mainly: hemostasis, clearing away damp-heat, lactogenesis.Herba Acroptili repentis is the aerial parts of feverfew Acroptilon repens Acroptilonrepens (L.) DC..Acrid in the mouth; Bitter; Cold in nature.Function cures mainly: wind-damp dispelling; Relieving heat toxin.Main rheumatic arthritis; Carbuncle sore tumefacting virus.Semen Aesculi is Hippocastanaceae plant Aesculus chinensis Bunge AesculuschinensisBge., Radix Aesculi AesculuschinensisBge.var.chekiangensis(HuetFang) dry mature seed of Fang or Aesculus AesculuswilsoniiRehd..Nature and flavor are sweet, temperature.Return liver, stomach warp.Regulating the flow of QI to ease the stomach, and stomach and alleviating pain.Radix Cinnamomi porrecti, is the aiphyllium of canella Camphor tree, uses its branch and leaf; Nature and flavor are micro-pungent, temperature; Merit can warming middle-JIAO to relieve pain, ward off dirty and in, expelling wind and removing dampness; Fructus Ailanthi is quassia ailanthus altissima (mill.) swingle Ailanthusaltissima(Mill.) fruit of Swingle.Nature and flavor: bitter, cool.Function cures mainly: clearing away heat and promoting diuresis, pain relieving, hemostasis.Semen Lini is the dry mature seed of flax family (Linaceae) linum Caulis et Folium Lini LinumusitatissimumL..Nature and flavor are sweet, tepor.Function cures mainly: loosening bowel to relieve constipation, nourishing blood to expel wind.For dryness of the intestine constipation; Old man's xerosis cutis Scaling, allergic dermatitis, skin pruritus; Skin infection eczema.Resina Liquidambaris is the dry resin of Hamamelidaceae Plants Chinese sweet gum LiquidambarformosanaHance.Pungent, the micro-hardship of nature and flavor, flat.Return lung, spleen channel.Function cures mainly: promoting blood circulation and stopping pain, removing toxic substances, granulation promoting, removing heat from blood.Gorgon fruit is the dry mature kernal of nymphaeaceae plant Gorgon euryale EuryaleferoxSalisb..Nature and flavor are sweet, puckery, flat.Gui Jing returns spleen, kidney channel.Function cures mainly: supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, damp eliminating leukorrhagia stopping.Herba Solani Lyrati is the herb of plant of Solanaceae Herba Solani Lyrati SolanumlyratumThunb..Sweet in the mouth; Bitter; Cold in nature.Return liver; Gallbladder; Kidney channel.Merit can clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.
In prior art with " relieve inflammation or internal heat (lung-fire, heart-fire, stomach-fire) moisturizes " to effect a permanent cure, take stopgap measures with " smooth throat to stop cough ", but in fact due to " cough caused by dryness " that the non-infectious children with cough of Among Children is not simple, dry pharynx, itching throat, cold air, speak etc. can cause cough, the pathology even had is shown as that mucus retention under larynx mucosa causes, and can not obtain good effect because " relieve inflammation or internal heat and moisturize " simply.Use antitussive medicine, sometimes central antitussive effect can be passed through in a short time, reduce coughre flex, reach antitussive object, but infant is recurrent exerbation in a week to two weeks often, its reason is that the mucosa infection swallowing rear wall does not improve, after antitussive medicine event resolves, coughre flex is replied, and symptom is staged a comeback.
Compared with prior art, the present invention has following characteristics:
1, this prescription do not use relieve inflammation or internal heat, moisturize, antitussive medicine, mucus retention under the visible retropharyneal folliculosis of child's non-infectious cough pathology and larynx mucosa, " dryness of the lung " that the non-infectious cough of child is not simple, but steam forms at lung network skewness, therefore we reach the object reducing coughre flex sensitivity by aproll of invigorating blood circulation, tracking lung network, thus reduce the generation of irritable cough;
2, in side with Herba pyrolae japonicae, precipice Rhizoma Zingiberis Recens for core, Herba pyrolae japonicae water extract can suppress the generation of skin-sensitizing antibodies in mice serum and house mouse spleen hemolytic cell, and precipice Rhizoma Zingiberis Recens can lead to lung network, and in order to reduce airway resistance, the two coordinates aproll, tracking lung network; For the non-infectious cough model of Cavia porcellus of ammonia and Oleum Terebinthinae modeling, Herba pyrolae japonicae, precipice Rhizoma Zingiberis Recens geometric ratio mixing water decocting liquid Neulized inhalation, (5min coughs number of times: medicine group 18.5 ± 8.2 effectively can to reduce guinea pig cough's frequency, model group 37.2 ± 10.8, the two compares, difference has statistical significance, P<0.05);
3, Folium Pterospermi Heterophylli, Herba Euphorbiae supinae all belong to promoting blood circulation and hemostasis medicine, but it is with being intended to by mucus retention under blood circulation rate alleviation larynx mucosa under increase mucosa in this prescription, reach the object of aproll of invigorating blood circulation, and above-mentioned two medicines have the merit of invigorating blood circulation, without hemorrhage anxiety, be particularly suitable for Neulized inhalation mucosa local and use;
4, Semen Aesculi, Radix Cinnamomi porrecti, Herba Acroptili repentis act as tracking lung network, Semen Aesculi, Radix Cinnamomi porrecti incubation yang-energy, gas moves with sun, and helps Folium Pterospermi Heterophylli to disperse aqueous vapor, and Herba Acroptili repentis is cold in nature, prevents yang-energy from containing very much and raw endogenous fire;
5, the volatile oil of Fructus Ailanthi decocting liquid and vapor extraction all presents comparatively highly acid, is conducive to the pH value of regulating drug, and the biological alkaline components of antagonism other drug is for the stimulation of mucosa, and therefore consumption is greater than conventional amount used;
6, Semen Lini can the excessive aproll band of gas of antagonism come impairment of body fluid;
7, the use meaning of Resina Liquidambaris and Gorgon fruit is all to increase bottleneck throat medicine adhesive force, and Resina Liquidambaris is micromolecule natural gum, is easy to ascension, can guide drugs adhere in bottleneck throat rapidly, and Tang Materia Medica records Resina Liquidambaris " acrid in the mouth is bitter, flat; nontoxic ", " working hard and putting down is Jin get Huo, with unboiled water ", nature and flavor are put down, then without the anxiety of cold and heat, also contain irritating compositions such as pinene unlike other resinae medicines, apply to Neulized inhalation, safe and reliable;
8, getting Herba Solani Lyrati in a small amount, is the meaning of using corrigent, the raw endogenous dryness to prevent warm drugs thing too.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: precipice Rhizoma Zingiberis Recens 15g, Herba pyrolae japonicae 15g, Folium Pterospermi Heterophylli 20g, Herba Euphorbiae supinae 12g, Semen Aesculi 15g, Radix Cinnamomi porrecti 15g, Herba Acroptili repentis 15g, Fructus Ailanthi 12g, Semen Lini 12g, Resina Liquidambaris 20g, Gorgon fruit 15g, Herba Solani Lyrati 2g.
The preparation method of embodiment 1 is: precipice Rhizoma Zingiberis Recens, Herba pyrolae japonicae, Folium Pterospermi Heterophylli, Herba Euphorbiae supinae, Herba Acroptili repentis, Semen Aesculi, Radix Cinnamomi porrecti, Fructus Ailanthi, Semen Lini, Resina Liquidambaris, Gorgon fruit, Herba Solani Lyrati mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, use two layers of filtered through gauze again, gained filtrate 60 DEG C ~ 70 DEG C is concentrated into density 1.15, airtight standing 8h after concentrated solution cooling, filter, to obtain final product.
Embodiment 2, crude drug weight proportion: precipice Rhizoma Zingiberis Recens 12 parts, Herba pyrolae japonicae 12 parts, Folium Pterospermi Heterophylli 10 parts, Herba Euphorbiae supinae 3 parts, Semen Aesculi 12 parts, Radix Cinnamomi porrecti 12 parts, Herba Acroptili repentis 12 parts, Fructus Ailanthi 3 parts, Semen Lini 3 parts, Resina Liquidambaris 10 parts, 12 parts, Gorgon fruit, Herba Solani Lyrati 1 part.
Embodiment 3, crude drug weight proportion: precipice Rhizoma Zingiberis Recens 15 parts, Herba pyrolae japonicae 15 parts, Folium Pterospermi Heterophylli 20 parts, Herba Euphorbiae supinae 12 parts, Semen Aesculi 15 parts, Radix Cinnamomi porrecti 15 parts, Herba Acroptili repentis 15 parts, Fructus Ailanthi 12 parts, Semen Lini 12 parts, Resina Liquidambaris 20 parts, 15 parts, Gorgon fruit, Herba Solani Lyrati 2 parts.
Embodiment 4, crude drug weight proportion: precipice Rhizoma Zingiberis Recens 20 parts, Herba pyrolae japonicae 20 parts, Folium Pterospermi Heterophylli 33 parts, Herba Euphorbiae supinae 12 parts, Semen Aesculi 20 parts, Radix Cinnamomi porrecti 20 parts, Herba Acroptili repentis 20 parts, Fructus Ailanthi 12 parts, Semen Lini 12 parts, Resina Liquidambaris 25 parts, 20 parts, Gorgon fruit, Herba Solani Lyrati 5 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Folium Pterospermi Heterophylli, Herba Euphorbiae supinae, Fructus Ailanthi, Radix Cinnamomi porrecti, precipice Rhizoma Zingiberis Recens, Semen Aesculi, Herba Solani Lyrati, Semen Lini, Resina Liquidambaris coarse powder are extracted volatile oil with vapor distillation respectively, obtain Mixed chaotic sequences and medicinal residues are for subsequent use;
(2) by gained medicinal residues mixing in Herba pyrolae japonicae, Herba Acroptili repentis, Gorgon fruit and step 1, add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill after filtered through gauze; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, airtight standing 48h, filter, through microporous membrane ultrafiltration after filtrate removing ethanol, filtrate concentrate drying, draws just material;
(3) sprayed into by gained volatile oil in step 1 during step 2 gained just expects, mixing, after pulverizing 100 mesh sieves, sterilizing formed.
The efficient combination of said medicine, coordinates mutually, effectively reach the effect played the non-infectious treatment of cough of child, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: in May, 2012 ~ in May, 2015, main suit was cough, and got rid of respiratory tract infection, the age, wherein male patient was 51 examples, and women's sufferer is 30 examples, and the mean age is 8.4 ± 1.3 years old, the course of disease 3 days ~ 1 month infant 81 example of 3 ~ 14 years old.Enter to organize sufferer clinical manifestation for paroxysmal cough, without expectorant or few expectorant; Auscultation of lung is without exception, and rabat, routine blood test, erythrocyte sedimentation rate etc. check performance all without exception; Get rid of tuberculosis, tumor etc.
1.1.2 divide into groups: be divided into matched group 27 example, liquid group 29 example and powder group 25 example.Compare in sex, age, the course of disease, cough integration etc. before three groups of infant treatments, no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 inhalable aerosol drug is selected: matched group uses sore-throat relieving atomization mixture (prescription: Herba Menthae, Radix Scrophulariae, the Rhizoma Anemarrhenae, Fructus Arctii, Periostracum Cicadae, Semen Sterculiae Lychnophorae, Radix Ophiopogonis, Radix Platycodonis, Fructus Schisandrae Chinensis) with " relieve inflammation or internal heat, moisturize, antitussive " effect according to list of references; Liquid group is with the embodiment of the present invention 1 gained Neulized inhalation liquid; Powder group is with gained sterile powder in the embodiment of the present invention 3.Within 10 ~ 14 years old, each using dosage is equivalent to crude drug amount 30g, within 6 ~ 10 years old, reduces by half, within 3 ~ 6 years old, reduces by half again.
1.2.2 Therapeutic Method: three groups of infants all adopt Treated by Inhalation of Ultrasonic Spray 7d, and concrete atomization method is: by medicine physiological saline solution and standardize solution is 15ml, carries out Neulized inhalation, treats 1 every day, each 15min.Three groups of infants initially all do not use antitussive medicine, and after 2 days as when the scoring of cough integration is 3, add with licorice mixture, within every year old, each 1ml(maximal dose is 10ml), every day 3 ~ 4 times.。" cough integration " (coughscore) standards of grading are comply with " 2013MIMS respiratory system disease guide ".
1.2.3 clinical efficacy judges: " the Chinese medical disease Standardization of diagnosis and curative effect " issued with reference to management board of national institute of traditional Chinese medicine, 1. fully recovers: after treatment, itching throat, cough all disappear, also without coughing fit after induction (have a joke induction, exercise induced); 2. effective: after treatment, itching throat, cough all disappear, and induction can bring out cough; 3. take a turn for the better: after treatment, itching throat, cough obviously alleviate; 4. invalid: after treatment, itching throat, cough are not improved.
1.2.4 statistical analysis: SPSS18.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of infant antitussive medicine service conditions compare: the antitussive medicine utilization rate in three groups of infant therapeutic processes is respectively matched group 29.63%(8/27), liquid group 6.9%(2/29), powder group 8.00%(2/25), difference has statistical significance (χ
2=4.92, P<0.05; χ
2=3.91, P<0.05).Result shows, liquid group, powder composing prescription case when not losing quality of life, can reduce antitussive medicine utilization rate.
2.2 3 groups of Clinical efficacy comparisons: after three groups of infants reject the case using antitussive medicine, Clinical efficacy comparison sees the following form,
| Group | Number of cases | Recovery from illness | Effective | Take a turn for the better | Invalid | Total effective rate | Cure rate |
| Matched group | 19 | 2 | 7 | 8 | 2 | 89.47% | 10.53% |
| Liquid group | 27 | 16 | 2 | 7 | 2 | 92.59% | 59.26% |
| Powder group | 23 | 11 | 7 | 4 | 1 | 95.65% | 47.83% |
After treatment 7d, the total effective rate of liquid group, powder group is higher than matched group, and difference does not have statistical significance (P>0.05).Cure rate comparative liquid group, powder group are then apparently higher than matched group (cure rate: χ
2=11.12, P<0.01; χ
2=6.67, P<0.01).Proved invents the beneficial effect that medicine that two kinds of embodiments obtain has good effect, not easily brings out.
In 2.3 3 months, relapse rate compares: all infants follow up a case by regular visits to three months, and relapse rate is respectively matched group 33.33%(9/27), liquid group 6.90%(2/29), powder group 8.00%(2/25), difference has statistical significance (χ
2=6.19, P<0.05; χ
2=4.99, P<0.05).Result shows, liquid group, powder composing prescription case effectively can reduce the non-infectious cough relapse rate of child in a short time.
2.4 untoward reaction and toleration: during medication and after drug withdrawal, three groups of infants all occur without the obvious heart, liver, kidney untoward reaction and symptoms of asthma.
3. conclusion.
This result of study shows, use the beneficial effect that liquid group of the present invention and powder group have good effect, not easily recur, can obvious relieving cough symptom, and have no adverse reaction, illustrate that medicine prepared by the inventive method has the advantage that curative effect is affirmed, safety is high in the non-infectious cough for the treatment of child.
Claims (1)
1. the non-infectious treatment of cough atomized liquid of child, is characterized in that being prepared from by the crude drug of following weight proportion: precipice Rhizoma Zingiberis Recens 12 ~ 20 parts, Herba pyrolae japonicae 12 ~ 20 parts, Folium Pterospermi Heterophylli 10 ~ 33 parts, Herba Euphorbiae supinae 3 ~ 12 parts, Semen Aesculi 12 ~ 20 parts, Radix Cinnamomi porrecti 12 ~ 20 parts, Herba Acroptili repentis 12 ~ 20 parts, Fructus Ailanthi 3 ~ 12 parts, Semen Lini 3 ~ 12 parts, Resina Liquidambaris 10 ~ 25 parts, 12 ~ 20 parts, Gorgon fruit, Herba Solani Lyrati 1 ~ 5 part.
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Application publication date: 20160210 |