CN105998725A - Traditional Chinese medicine preparation for treating silicosis - Google Patents

Traditional Chinese medicine preparation for treating silicosis Download PDF

Info

Publication number
CN105998725A
CN105998725A CN201610334728.7A CN201610334728A CN105998725A CN 105998725 A CN105998725 A CN 105998725A CN 201610334728 A CN201610334728 A CN 201610334728A CN 105998725 A CN105998725 A CN 105998725A
Authority
CN
China
Prior art keywords
radix
chinese medicine
medicine preparation
lung
herba
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610334728.7A
Other languages
Chinese (zh)
Inventor
张华�
肖华
刘凤娟
谭瑞霞
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qingdao Central Hospital
Original Assignee
Qingdao Central Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qingdao Central Hospital filed Critical Qingdao Central Hospital
Priority to CN201610334728.7A priority Critical patent/CN105998725A/en
Publication of CN105998725A publication Critical patent/CN105998725A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • A61K36/428Trichosanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966Fritillaria, e.g. checker lily or mission bells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968Ophiopogon (Lilyturf)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969Polygonatum (Solomon's seal)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8984Dendrobium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation

Abstract

The invention provides a traditional Chinese medicine preparation for treating silicosis. The traditional Chinese medicine preparation is prepared from raw materials of radix glehniae, radix ginseng, radix ophiopogonis, fructus schisandrae chinensis, radix rehmanniae, herba dendrobii, rhizoma polygonati odorati, bulbus fritillariae thunbergii, fructus trichosanthis, folium eriobotryae (mixed-fried), radix asteris, flos farfarae, rhizoma pinelliae preparatum, radix angelicae sinensis, radix salviae miltiorrhizae, radix platycodonis, radix glycyrrhizae(raw), pheretima, pericarpium citri reticulatae, exocarpium citri grandis, poria, gecko, radix astragali(raw), cortex mori, hirudo, herba ephedrae(mixed-fried), placenta hominis, radix bupleuri, donkey-hide gelatin, apricot kernel, radix rubiae, herba cirsii, cortex lycii and radix cynanchi atrati. The traditional Chinese medicine preparation has the advantage of realizing treatment based on syndrome differentiation, overcomes the failure in distinguishing pattern of syndrome in the conventional western medicine, and effectively relieves symptom, delays progression of disease situation, prolongs patient's life and improves quality of patient's life.

Description

For treating the Chinese medicine preparation of pneumosilicosis
Technical field
The present invention relates to technical field of Chinese medicine, particularly relate to a kind of Chinese medicine preparation for treating pneumosilicosis.
Background technology
Pneumosilicosis, also known as silicosis, is a type most commonly seen in pneumoconiosis, is to suck a large amount of free titanium dioxide due to long-term Caused by silica soot, based on the disease of pulmonary's nodular fibrosis widely.Pneumosilicosis be most common in pneumoconiosis, progress is the fastest, Endanger a most serious type.The new patient of pneumoconiosis about the most promising 20,000 examples of China occurs, its principal pathogenetic feature is duty Industryization is distributed, i.e. the long-term dust such as sanitationman, miner, traffic police, teacher contact colony.Therefore, pneumoconiosis is as a kind of main Respiratory tract occupation disease, its preventing and treating is a large order.
By its cause of disease is analyzed, mainly by: 1, dust in air concentration, i.e. dissociate SiO2Content is at environment dust In free SiO2Content is the highest, and dust concentration is the biggest, then the harm caused is the biggest.Dust concentration is with mg/m3Represent, when in dust Free SiO2Content is relatively big, and dense (tens of even hundreds of mg/m3), after long-term suction, lung tissue forms silicon knot Joint;2, time of contact, the development of pneumosilicosis is a chronic process, is typically persistently sucking silicious dust 5~morbidity in 10 years, and have is up to More than 5~20 years.But persistently suck high concentration, the dust of high free silica content, can fall ill through 1~2 year, be referred to as speed Hair style pneumosilicosis;3, dust dispersity, dispersion is to represent that one of dust granules size is measured, with particle diameters various in dust The percentage composition of size represents.Ratio shared by little granule dust is bigger, then dispersion is the biggest.Dispersion size and grit There is substantial connection at aerial floating and its detention position in respiratory tract.Diameter is more than 10um powder dust particle in atmosphere Quickly settling, even if sucking also by nasal cavity vibrissa detention, discharging with blowing tears;The dust of below 10um, the overwhelming majority is by upper breathing The detention of road institute;The dust of below 5um, can enter alveolar;The dust of below 0.5um, because its gravity is little, not free settling, with expiration Discharge, therefore detention rate declines;And < dust of below 0.1um increases on the contrary because of brownian movement, detention rate;4, collective's state, people Body respiratory tract has a series of defence installation, the dust of suction, when first passing through nasal cavity, because of filter dirt effect and the nasal septum of vibrissa Bend and detention, generally suck the 30%~50% of Dust Capacity;Entering tracheobronchial dust, extreme portions can be by propping up The bifurcated of trachea tree, mucosal epithelium ciliary movement and detention are also discharged with expectorant;Part grit is huge by macrophage or alveolar spaces Phagocyte phagocytosis becomes dust cell, dust cell or the free grit not swallowed can enter hilar lymph node along lymphatic vessel.
The common pulmonary tuberculosis of its complication, pulmonary infection, chronic bronchitis and obstructive emphysema etc., severe patient even has Spontaneous pneumothorax occurs.
Unfortunately, doctor trained in Western medicine does not provide corresponding effective therapeutic modality for pneumosilicosis, patient's Progressive symmetric erythrokeratodermia or (with) permanent forfeiture muscle power, and ultimately result in maimed person or die from respiratory failure or die from other complication, doctor trained in Western medicine is only capable of After it is made a definite diagnosis, it is proposed that patient departs from dust work, take positive comprehensive control measures, especially for its complication, as Phthisical Drug therapy, carrys out mitigation symptoms with this, delays disease progression, raising patient's life-span, raising quality of life of patients.
The traditional Chinese medical science focuses on holistic approach in the diagnosis of disease, prevention, therapeutic process, uses determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs mode comprehensive Solve disease, pneumoconiosis is belonged to traditional Chinese medical science lung-QI stagnation syndrome category, is summarized as insufficiency of lung-QI, deficiency of lung-YIN, turbid phlegm obstructing in the lung, obstruction of collaterals by blood stasis four card Waiting, however as improvement, the raising of medical condition of material conditions, the lung-QI stagnation syndrome of single pattern of syndrome is more difficult to be seen, often deficiency and excess folder Miscellaneous pattern of syndrome, lungs deficiency of both QI and YIN, phlegm-turbidity and blood stasis blood internal resistance, therefore by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, give and supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, only Coughing Apophlegmatisant, verification treatment, Chinese medicine has the irreplaceable advantage of Western medicine in terms of preventing and treating pneumoconiosis.In particular with Modern medical techniques and the combination of Chinese medicine, many Chinese medicines and Chinese medicine extract be widely used in pneumoconiosis clinical research, In treatment, for clinical mitigation symptoms, disease progression, raising patient's life-span, raising quality of life of patients is delayed to bring Gospel.
Summary of the invention
The technical problem to be solved is to provide a kind of Chinese medicine preparation for treating pneumosilicosis, has determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs Advantage, overcome tradition Western medicine and cannot be distinguished by pattern of syndrome and carry out verification treatment, effective mitigation symptoms, delay disease progression, raising Patient's life-span, raising quality of life of patients.
For solving above-mentioned technical problem, the present invention provides a kind of Chinese medicine preparation for treating pneumosilicosis, and its crude drug includes Radix Glehniae, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae, Herba Dendrobii, Rhizoma Polygonati Odorati, Bulbus Fritillariae Thunbergii, Fructus Trichosanthis, Folium Eriobotryae (processed), Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Platycodonis, Radix Glycyrrhizae, Pheretima, Pericarpium Citri Reticulatae, Exocarpium Citri Grandis, Poria, Gecko, Radix Astragali, Cortex Mori, Hirudo, process Herba Ephedrae, Placenta Hominis, Radix Bupleuri, Colla Corii Asini, Semen Armeniacae Amarum, Radix Rubiae, Herba Cirsii, Cortex Lycii and Radix Cynanchi Atrati.
Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively Radix Glehniae 25g~35g, Radix Ginseng 15g~20g, wheat Door winter 25g~35g, Fructus Schisandrae Chinensis 10g~15g, Radix Rehmanniae 30g~35g, Herba Dendrobii 25g~35g, Rhizoma Polygonati Odorati 15g~20g, Bulbus Fritillariae Thunbergii 10g~15g, Fructus Trichosanthis 15g~20g, Folium Eriobotryae (processed) 10g~15g, Radix Asteris 15g~20g, Flos Farfarae 10g~20g, Rhizoma Pinelliae Preparatum 10g ~15g, Radix Angelicae Sinensis 20g~30g, Radix Salviae Miltiorrhizae 15g~20g, Radix Platycodonis 10g~15g, Radix Glycyrrhizae 15g~25g, Pheretima 5g~10g, Pericarpium Citri Reticulatae 15g~20g, Exocarpium Citri Grandis 10g~15g, Poria 25g~30g, Gecko 20g~30g, Radix Astragali 20g~30g, Cortex Mori 10g~ 20g, Hirudo 5g~8g, Herba Ephedrae (processed) 6g~10g, Placenta Hominis 10g~15g, Radix Bupleuri 10g~15g, Colla Corii Asini 10g~15g, Semen Armeniacae Amarum 6g ~10g, Radix Rubiae 10g~15g, Herba Cirsii 10g~15g, Cortex Lycii 10g~15g, Radix Cynanchi Atrati 10g~15g.
Wherein, in described Chinese medicine preparation, the weight of each crude drug is respectively Radix Glehniae 30g~35g, Radix Ginseng 15g~20g, wheat Door winter 30g~35g, Fructus Schisandrae Chinensis 10g~15g, Radix Rehmanniae 30g~35g, Herba Dendrobii 25g~30g, Rhizoma Polygonati Odorati 15g~20g, Bulbus Fritillariae Thunbergii 12g~15g, Fructus Trichosanthis 15g~20g, Folium Eriobotryae (processed) 10g~15g, Radix Asteris 15g~20g, Flos Farfarae 10g~15g, Rhizoma Pinelliae Preparatum 10g ~12g, Radix Angelicae Sinensis 25g~30g, Radix Salviae Miltiorrhizae 15g~20g, Radix Platycodonis 12g~15g, Radix Glycyrrhizae 20g~25g, Pheretima 5g~10g, Pericarpium Citri Reticulatae 15g~20g, Exocarpium Citri Grandis 10g~15g, Poria 25g~30g, Gecko 20g~25g, Radix Astragali 25g~30g, Cortex Mori 10g~ 15g, Hirudo 5g~8g, Herba Ephedrae (processed) 6g~9g, Placenta Hominis 10g~15g, Radix Bupleuri 12g~15g, Colla Corii Asini 10g~15g, Semen Armeniacae Amarum 6g~ 8g, Radix Rubiae 10g~15g, Herba Cirsii 10g~15g, Cortex Lycii 10g~15g, Radix Cynanchi Atrati 10g~12g.
Wherein, in described Chinese medicine preparation the weight of each crude drug be respectively Radix Glehniae 30g, Radix Ginseng 15g, Radix Ophiopogonis 30g, five Taste 10g, Radix Rehmanniae 30g, Herba Dendrobii 30g, Rhizoma Polygonati Odorati 20g, Bulbus Fritillariae Thunbergii 12g, Fructus Trichosanthis 15g, Folium Eriobotryae (processed) 15g, Radix Asteris 15g, coltsfoot Flower 15g, Rhizoma Pinelliae Preparatum 12g, Radix Angelicae Sinensis 25g, Radix Salviae Miltiorrhizae 15g, Radix Platycodonis 12g, Radix Glycyrrhizae 20g, Pheretima 10g, Pericarpium Citri Reticulatae 15g, Exocarpium Citri Grandis 10g, Poria 30g, Gecko 25g, Radix Astragali 25g, Cortex Mori 15g, Hirudo 8g, Herba Ephedrae (processed) 9g, Placenta Hominis 15g, Radix Bupleuri 12g, Colla Corii Asini 10g, Semen Armeniacae Amarum 8g, Radix Rubiae 15g, Herba Cirsii 15g, Cortex Lycii 15g, Radix Cynanchi Atrati 12g.
Wherein, described Chinese medicine preparation technique routinely add adjuvant make tablet, capsule, granule, the watered pill, micropill, Dispersible tablet, oral cavity disintegration tablet, pill or oral liquid.
Wherein, described Chinese medicine preparation is prepared as oral liquid.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, comprising:
The first step, take by weight Radix Glehniae, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae, Herba Dendrobii, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Pheretima, Pericarpium Citri Reticulatae, Exocarpium Citri Grandis, Gecko, Radix Astragali, Hirudo, Placenta Hominis, Radix Bupleuri, Semen Armeniacae Amarum, Cortex Lycii and Radix Cynanchi Atrati are cleaned respectively, pulverize, mixing Together, being subsequently added Colla Corii Asini, adding the determining alcohol mixing quality of medicinal material 8~10 times amount obtained relative to this step is 80% ~90% ethanol, heating and refluxing extraction 3 times, each 1~2 hour, united extraction liquid;The extracting solution decompression recycling ethanol of gained, Being concentrated into 0.5g crude drug/ml, be 1.5~4 with acid for adjusting pH, let cool, filter, on filtrate, resin volume is equivalent to crude drug medicinal liquid body The macroporous resin column of long-pending 2~4 times, first rinses with 1~1.5 times of cylinder hydrops, and water lotion discards, then the alcohol with 2~3 times of column volumes Concentration is 85~95% ethanol elution, collects eluent, and eluent is evaporated to extractum, 60 DEG C of vacuum drying, taking-up, powder Broken, it is thus achieved that powder;
Second step, cleans remainder crude drug component respectively, is mixed in proportion, and is preceded by stating 3-5 times of medical material gross weight Soak by water 2 hours, filter, filtering residue adds the soak by water 1.5 hours of 3-5 times of above-mentioned medical material gross weight again, filters, merging 2 decoction liquor, filter, and when being concentrated into 70 DEG C, relative density are 1.05, are cooled to room temperature, add dehydrated alcohol, make medicinal liquid Containing alcohol volume is 70%, stirs evenly, and stands 24 hours, takes supernatant, and after reclaiming ethanol, when being concentrated into 60 DEG C, relative density is 1.25 extractum;
The extractum mixing that 3rd step, the powder first step obtained and second step obtain, adds corresponding adjuvant, is prepared as Corresponding dosage form.
Wherein, when being prepared as oral liquid, described 3rd step is specially the powder and second first step obtained further The extractum mixing that step obtains, adds water to 500ml, and heated and stirred, to being completely dissolved, is subsequently added 3.0g steviosin, stirring so that it is Fully dissolving, after cooling, add ethyl hydroxybenzoate 0.5g, add water and adjust to 950ml, regulation pH value, to 6.6-7.0, stands 24 little Time;4800rpm is centrifuged 20 minutes, takes supernatant, and the adjustment total amount that adds water, to 1000ml, stirs evenly, subpackage, and 100 DEG C of flowing steams go out Bacterium 30 minutes.
Useful technique effect
The Chinese medicine preparation for treating pneumosilicosis that the present invention provides, has the advantage of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, overcomes tradition Western medicine Cannot be distinguished by pattern of syndrome carry out verification treatment, effective mitigation symptoms, delay disease progression, improve patient's life-span, improve patient life Quality.
Detailed description of the invention
The present invention provides a kind of Chinese medicine preparation for treating pneumosilicosis, its crude drug include Radix Glehniae, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae, Herba Dendrobii, Rhizoma Polygonati Odorati, Bulbus Fritillariae Thunbergii, Fructus Trichosanthis, Folium Eriobotryae (processed), Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Citri tangerinae Stalk, Radix Glycyrrhizae, Pheretima, Pericarpium Citri Reticulatae, Exocarpium Citri Grandis, Poria, Gecko, Radix Astragali, Cortex Mori, Hirudo, Herba Ephedrae (processed), Placenta Hominis, Radix Bupleuri, Ah Glue, Semen Armeniacae Amarum, Radix Rubiae, Herba Cirsii, Cortex Lycii and Radix Cynanchi Atrati.
Pneumosilicosis is the one of interstitial pulmonary fibrosis, is that Diffuse alveolar caused by dust is scorching and alveolar structure disorderly and Causing the disease of interstitial pulmonary fibrosis eventually, the sick position of silicotic fibrosis is at lung and relevant to multi viscera, in disease develops, many Weak with self, the poison experiencing metal and stone is evil, and heresy is hindered healthy energy, made deficiency of both QI and YIN, the most then blood stasis lung network, therefore in treatment, sick the most To get rid of evils, prolonged illness is then cloudy with tonification gas, and promoting blood circulation to remove obstruction in the collateral is main.Chinese medicine preparation of the present invention uses Radix Glehniae, Radix Ginseng, Mai Men Winter, Fructus Schisandrae Chinensis are monarch drug group, Radix Glehniae nourishing YIN and clearing away lung-heat, expelling phlegm for arresting cough, Radix Ginseng strongly invigorating primordial QI, YIN nourishing and the production of body fluid promoting, and Radix Ophiopogonis supports lung stomach The moon, pathogenic heat are promoted the production of body fluid, reduce phlegm preventing or arresting vomiting, and Fructus Schisandrae Chinensis is astringed the lung, and nourishing kidney is promoted the production of body fluid, and receive antiperspirant, arresting seminal emission, cure mainly the deficiency of the lung and breath with cough, and four medicines share altogether Play effect of supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid;It is clear that Chinese medicine preparation of the present invention adds Radix Rehmanniae, Herba Dendrobii, Rhizoma Polygonati Odorati YIN nourishing and the production of body fluid promoting, lung moistening Heat, wherein Radix Rehmanniae replenishing YIN and removing heat, the moon of kind invigorating the liver and kidney, lung kidney is mutual generation between metal and water, and the moon of the kidney invigorating can support the moon of lung, Herba Dendrobii stomach reinforcing Promote the production of body fluid, nourishing YIN and clearing away heat, Rhizoma Polygonati Odorati yin nourishing, moisturize, heat clearing away, promote the production of body fluid, cough-relieving, dry to not this cause of disease poison heresy impairing the lung, consumption of YIN caused by febrile disease, deficiency-heat Coughed well effect, simultaneously modern medicine study its have good therapeutical effect, in addition modern pharmacological research for tuberculosis Prove that Rhizoma Polygonati Odorati can reduce neutrophilic granulocyte activity, suppress it to discharge toxin, to reduce collagen in pulmonary interstitial cells and basement membrane Destruction, the most all medicines coordinate, assist monarch drug play YIN nourishing and the production of body fluid promoting, moistening lung and clearing heat altogether, for ministerial drug group;For patient because of the poison of metal and stone Evil impairing the lung, it is impossible to detoxify in lungs, when lung moistening expectoration is for wanting, and Chinese medicine preparation of the present invention adds lung moistening expectoration or activating QI to eliminate phlegm Medicine, such as Bulbus Fritillariae Thunbergii, Fructus Trichosanthis, Folium Eriobotryae (processed), Radix Asteris, Flos Farfarae, Pericarpium Citri Reticulatae, Exocarpium Citri Grandis, wherein reuses Bulbus Fritillariae Thunbergii removing heat-phlegm, dissipates Knot removing toxic substances, its removing toxic substances profit expectorant, the effect opening lung qi dispersing gas is notable, and Folium Eriobotryae (processed), Radix Asteris, Flos Farfarae three medicine are that nourishing the lung to arrest cough is conventional Medicine group, three medicines share lung heat clearing be combined into, lowering the adverse-rising QI to resolve phlegm, especially for primary disease occur development initial stage, mid-term, lung-heat phlegm dyspnea, Hemoptysis, epistaxis etc. have well verifies therapeutical effect, and wherein Folium Eriobotryae (processed) also coordinates special lung moistening dry, only with Cortex Mori, Radix Glehniae Cough with asthma, Radix Asteris and the Colla Corii Asini nourishing YIN and moistening the lung power that matches is strong, and Flos Farfarae and Pericarpium Citri Reticulatae, Exocarpium Citri Grandis match lung moistening, the preventing phlegm from forming and stopping coughing of regulating the flow of vital energy, for The dry patient itched of deficiency of YIN cough caused by dryness, throat, has effect that good lung moistening expectoration, cough-relieving are antipruritic;Chinese medicine preparation of the present invention uses Herba Ephedrae (processed), Semen Armeniacae Amarum, two medicines enter lung meridian, large intestine channel, with the use of having relieving cough and asthma, loosening bowel to relieve constipation, with aforementioned moistening the lung and resolving phlegm medicine Coordinating, treatment silicious dust deposition is not gone, and heat-transformation Tianjin of burning is expectorant, the expectorant plug stagnation of QI hinder occur in the lung pulse cough, cough up the diseases such as the viscous expectorant of white Shape, Cortex Mori eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema, in primary disease evolution, after lung injury, lung-heat cough with asthma, the edema of the face, little In the most unfavorable stage, there is preventative-therapeutic advantage, the generation of primary disease development by containing in initial stage poison heresy, healthy energy the most empty, gradually send out Generated deficiency of both QI and YIN, obstruction of collaterals by blood stasis, lung being a delicate viscus, gas consumption blood trouble makes lungs function damage more serious, Chinese medicine preparation of the present invention Adding Pheretima, Hirudo, two medicines are insect medicine, and property is walked to alter, kind removing blood stasis, eliminating mass of stimulating the menstrual flow, and enter lung with guiding drug, removing blood stasis promoting the circulation of blood, Improving because stopping in the poison blood stasis that causes of impairing the lung network, use Radix Salviae Miltiorrhizae, Radix Rubiae, Herba Cirsii to enter blood system, cooling blood for hemostasis, because of the poison damage of metal and stone Lungs QI and blood venation, causes outside blood arteries and veins, adds three medicines, plays clearing away heat and cooling blood altogether, effect that blood stasis dispelling stimulates the menstrual flow, and wherein Radix Rubiae is stopped blooding not Stay the stasis of blood, actually key medicine, add Cortex Lycii, Radix Cynanchi Atrati clearing away deficiency-heat, coordinate the monarch and his subjects' medicine group on the basis of replenishing YIN and removing heat, clear up and discharge and be reluctant to leave Deficiency-heat, two medicines have good therapeutical effect for the cough of primary disease complicated with pulmonary tuberculosis, expectoration, hemoptysis in addition, specially control asthenia tide Hot night sweat, lung-heat cough with asthma, spit blood, epistaxis, add Radix Angelicae Sinensis, Placenta Hominis, Colla Corii Asini nourshing blood and promoting blood circulation, strengthening the body resistance, when being classified as nourishing blood it Key medicine, cures mainly all cards of blood deficiency, also can invigorate blood circulation, and makes above-mentioned all medicines share, enriches blood and do not stay the stasis of blood, and blood stasis dispelling is not just being hindered, and modern pharmacology grinds Study carefully and show that Radix Angelicae Sinensis can improve microcirculation, alleviate bronchospasm and promote that inflammation absorbs, reduce macrophage release fibrous joints egg In vain, it is ensured that the gas exchange of blood between alveolar cell and tissue, improve anaerobic condition, and there is anti-radical action, Ke Yiyan Delaying or barrier fibers process, Placenta Hominis, Colla Corii Asini are the product that flesh and blood is in love, and its temperature gas supplementing Resina Draconis is special, nourish essence and blood power strong, wherein Placenta Hominis enters lung, the heart, kidney channel, and modern medicine study is thought, Placenta Hominis swashs containing protein, sugar, calcium, vitamin, immune factor, women Element, gravidity assisting ketone, steroid hormone, promoting sexual gland hormone, thyroliberin etc., to pulmonary tuberculosis, bronchial asthma, anemia etc. Also good effect, all medicines is had to share the effect playing Qingre Quyu, cooling blood for hemostasis, nourshing blood and promoting blood circulation altogether;Lung spleen is mothers and sons, Chinese medicine system of the present invention Agent uses Radix Astragali, Rhizoma Pinelliae Preparatum, Radix Glycyrrhizae, Poria, and Radix Astragali coordinates monarch drug Radix Ginseng strongly invigorating primordial QI, also can invigorating the spleen and replenishing QI, method half Summer is drying damp and strengthening spleen, helps spleen transporting, Radix Glycyrrhizae heat-clearing and toxic substances removing, invigorating the spleen and replenishing QI, simultaneously can be with coordinating the actions of various ingredients in a prescription, Poria invigorating the spleen and benefiting QI, profit Wet helping fortune, four medicines share the effect playing invigorating the spleen and benefiting QI, building up the spleen to supplement the lung altogether;One striking features of Chinese medicine preparation of the present invention is in treatment The when of primary disease, adding Gecko simply, Gecko tonifying the lung gas, Dingchuan is quenched the thirst, the same Radix Ginseng of merit, and tonifying YIN blood helps essence to hold up thin, and impairment of the lung caused by overstrain is coughed Coughing, drench drip person, all lung kidneys are disease, and labor pole then lung is suffered from a deficiency of the kidney and heat, therefore exopathogen is easily invaded, and internal evidence is held concurrently and sent out also.Clam Eriocheir sinensis belongs to the moon, can moisturizing On source, then lung kidney all be supported, and consumptive fever cough oneself remove;The convergence of vessels in the lung, regulating fluid apssage, under defeated bladder, normal lung-QI, thus drench drip Water channel is from leading to also, and all medicines share, and are adjuvant drug altogether;Chinese medicine preparation of the present invention uses Radix Bupleuri reconciling superficies and interior, Shugan Qingre, liter of regulating the flow of vital energy Sun, and the gas that Pericarpium Citri Reticulatae adjusts smooth the whole body, Radix Platycodonis opens lung qi dispersing gas, is again lung meridian guiding drug, and medicine carrying is up, for making medicine.All formulas are matched, pin The etiology and pathogenesis of primary disease is verified medication, there is good supplementing QI and nourishing YIN, blood circulation promoting and blood stasis dispelling, relieving cough and resolving phlegm effect, alleviate for clinic Symptom, delay disease progression, improve patient's life-span, improve quality of life of patients bring Gospel.
Further preferably, described Chinese medicine preparation is only prepared from by above-mentioned raw materials medicine.
In described Chinese medicine preparation, the weight of each crude drug is respectively Radix Glehniae 25g~35g, Radix Ginseng 15g~20g, Radix Ophiopogonis 25g~35g, Fructus Schisandrae Chinensis 10g~15g, Radix Rehmanniae 30g~35g, Herba Dendrobii 25g~35g, Rhizoma Polygonati Odorati 15g~20g, Bulbus Fritillariae Thunbergii 10g~ 15g, Fructus Trichosanthis 15g~20g, Folium Eriobotryae (processed) 10g~15g, Radix Asteris 15g~20g, Flos Farfarae 10g~20g, Rhizoma Pinelliae Preparatum 10g~15g, Radix Angelicae Sinensis 20g~30g, Radix Salviae Miltiorrhizae 15g~20g, Radix Platycodonis 10g~15g, Radix Glycyrrhizae 15g~25g, Pheretima 5g~10g, Pericarpium Citri Reticulatae 15g~ 20g, Exocarpium Citri Grandis 10g~15g, Poria 25g~30g, Gecko 20g~30g, Radix Astragali 20g~30g, Cortex Mori 10g~20g, water Trematodiasis 5g~8g, Herba Ephedrae (processed) 6g~10g, Placenta Hominis 10g~15g, Radix Bupleuri 10g~15g, Colla Corii Asini 10g~15g, Semen Armeniacae Amarum 6g~10g, Radix Rubiae 10g~15g, Herba Cirsii 10g~15g, Cortex Lycii 10g~15g, Radix Cynanchi Atrati 10g~15g.
Further preferably, in described Chinese medicine preparation the weight of each crude drug be respectively Radix Glehniae 30g~35g, Radix Ginseng 15g~ 20g, Radix Ophiopogonis 30g~35g, Fructus Schisandrae Chinensis 10g~15g, Radix Rehmanniae 30g~35g, Herba Dendrobii 25g~30g, Rhizoma Polygonati Odorati 15g~20g, Zhejiang Bulbus Fritillariae Uninbracteatae 12g~15g, Fructus Trichosanthis 15g~20g, Folium Eriobotryae (processed) 10g~15g, Radix Asteris 15g~20g, Flos Farfarae 10g~15g, Rhizoma Pinelliae Preparatum 10g~12g, Radix Angelicae Sinensis 25g~30g, Radix Salviae Miltiorrhizae 15g~20g, Radix Platycodonis 12g~15g, Radix Glycyrrhizae 20g~25g, Pheretima 5g~10g, old Skin 15g~20g, Exocarpium Citri Grandis 10g~15g, Poria 25g~30g, Gecko 20g~25g, Radix Astragali 25g~30g, Cortex Mori 10g ~15g, Hirudo 5g~8g, Herba Ephedrae (processed) 6g~9g, Placenta Hominis 10g~15g, Radix Bupleuri 12g~15g, Colla Corii Asini 10g~15g, Semen Armeniacae Amarum 6g ~8g, Radix Rubiae 10g~15g, Herba Cirsii 10g~15g, Cortex Lycii 10g~15g, Radix Cynanchi Atrati 10g~12g.
Most preferably, in described Chinese medicine preparation the weight of each crude drug be respectively Radix Glehniae 30g, Radix Ginseng 15g, Radix Ophiopogonis 30g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae 30g, Herba Dendrobii 30g, Rhizoma Polygonati Odorati 20g, Bulbus Fritillariae Thunbergii 12g, Fructus Trichosanthis 15g, Folium Eriobotryae (processed) 15g, Radix Asteris 15g, money Flos Farfarae 15g, Rhizoma Pinelliae Preparatum 12g, Radix Angelicae Sinensis 25g, Radix Salviae Miltiorrhizae 15g, Radix Platycodonis 12g, Radix Glycyrrhizae 20g, Pheretima 10g, Pericarpium Citri Reticulatae 15g, Exocarpium Citri Grandis 10g, Poria 30g, Gecko 25g, Radix Astragali 25g, Cortex Mori 15g, Hirudo 8g, Herba Ephedrae (processed) 9g, Placenta Hominis 15g, Radix Bupleuri 12g, Ah Glue 10g, Semen Armeniacae Amarum 8g, Radix Rubiae 15g, Herba Cirsii 15g, Cortex Lycii 15g, Radix Cynanchi Atrati 12g.
Each crude drug pharmacology is as follows:
Radix Glehniae: cold nature, sweet in the mouth, micro-hardship, there is nourishing YIN and clearing away lung-heat, effect of reinforcing stomach reg fluid, cure mainly lung-heat type cough, chronic cough The cards such as expectorant blood, calentura Tianjin wound are thirsty.
Radix Ginseng: sweet in the mouth, micro-hardship, slightly warm in nature, enters the heart, lung, spleen channel, has strongly invigorating primordial QI, using tonifying Qi reinforcing lungs, promoting the production of body fluid to quench thirst, calm the nerves The effects such as Fructus Alpiniae Oxyphyllae, both held up danger for emergency treatment of collapse good dose, also for treating the first key medicine of asthenia internal injury, the card of all insufficiency of vital energy and bloods all may be used Application, cure mainly that impairment caused by overstrain is deficient, food is told in lack of appetite, asthenia, regurgitation, stool lingering diarrhea, void cough with asthma rush, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizzy Dizzy headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency is multiple etc. demonstrate,proves.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature, enters the heart, lung, stomach warp, has the work that nourishing YIN and moistening the lung, preventing phlegm from forming and stopping coughing, heat clearing away are nourished heart With, be mainly used in pathogenic dryness impairing the lung or lung-dryness syndrome due to deficiency of YIN have the dry cough expectorant of heat to stick, chronic cough hemoptysis, dry pharynx dryness in the nasal cavity, lung abscess, thermal burn stomach-Yin or Dry mouth and throat caused by deficiency of stomach-Yin, red tongue lacks tongue, vague epigastralgia, and interior-heat is quenched one's thirst, and constipation due to dry stool, deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed And the heart-nutriment and the dysphoria and insomnia that causes, crimson tongue and dry wait card.
Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, enter lung, the heart, kidney channel, there is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the work of kidney calming With.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat disappears Yearningly, the card such as palpitation and insomnia.
Radix Rehmanniae: sweet in the mouth, hardship, cold in nature, enter the heart, liver, kidney channel, have clearing away heat and cooling blood, eliminating blood stasis to promote regeneration of blood, the effect of YIN nourishing and the production of body fluid promoting, It is mainly used in the Kidney-Yin cards being robbed such as fever of the body is thirsty of heat such as battalion point;Or calentura later stage continuous low fever;Chronic disease card belongs to the deficiency of YIN Interior-heat person;The thirst and drinking of accumulated heat in the lung and stomach, quenches one's thirst vexed, thirsty few Tianjin that stomach-Yin is injured;Under the having blood in stool of bleeding due to blood-heat, metrorrhagia Blood;Purple black grade of speckle of sending out of heat in blood poison Sheng is demonstrate,proved.
Herba Dendrobii: latin name Dendrobii Caulis, cold nature, sweet in the mouth, returns stomach, kidney channel, has reinforcing stomach reg fluid, and YIN nourishing is clear The cards such as effect of heat, cures mainly cloudy impairment of body fluid and lose, xerostomia excessive thirst, and lack of appetite is retched, deficiency-heat after being ill, poor vision.
Rhizoma Polygonati Odorati: latin name Polygonati Odorati Rhizoma, sweet in the mouth, property is put down, is attached to the lung and stomach meridians, and has YIN nourishing profit Lung, effect of nourishing the stomach to promote the production of body fluid, cure mainly cough caused by dryness;Chronic cough;The dry throat and mouth of calentura the moon liquid consumption wound;Interior-heat is quenched one's thirst;Deficiency of YIN diseases caused by exogenous pathogenic factor;Dizzy Dizziness;Muscle arteries and veins spasm and pain etc. are demonstrate,proved.
Bulbus Fritillariae Thunbergii: bitter in the mouth, cold in nature, enter lung, heart channel, there is removing heat-phlegm, effect of powder detoxifcation, cure mainly cough due to pathogenic wind-heat, Lung abscess sore throat, scrofula, sore swollen toxin etc. is demonstrate,proved.
Fructus Trichosanthis: sweet in the mouth, micro-hardship, cold in nature, enter lung, stomach, large intestine channel, there is removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, the merit of loosening bowel to relieve constipation Effect, the cards such as cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.
Folium Eriobotryae: bitter, is slightly cold, returns lung, stomach warp, have clearing away lung-heat to relieve cough, effect of stopping nausea and vomiting by lowering the adverse flow of QI, and this product bitter cold can lung heat clearing Heat, fall lung qi, with cough-relieving, is usually used in treating cough due to lung-heat, abundant expectoration yellow skin, can drop gastric qi and preventing or arresting vomiting is inverse, for vomitting that gastric heat causes Inverse, treatment xerostomia is quenched one's thirst, lung-wind syndrome acne vulgaris, acne, " book on Chinese herbal medicine converges and says ": Folium Eriobotryae, pacifies gastric qi, moistens cardiopulmonary, and the medicine of nourishing the liver and kidney is also.Shen Front yard, hole is said: main vomitting is vomited regurgitation and told food incessantly, and peace gastric qi is also;Or QI rising in reverse order expectorant is stagnant and cough and waste peaceful, lung moistening gas is also;Or asthenic fire is tired And dry tongue mouth bath, foster kidney qi is also;Or pestilence summer-heat?And heat is thirsty puzzled, the cool motive is also.
Radix Asteris: bitter in the mouth, warm in nature, there is warming the lung, the therapeutic method to keep the adverse QI flowing downwards, expectorant, effect of cough-relieving.Curing mainly cough due to wind and cold's asthma, asthenia is coughed Vomiting bloody pus, sore throat, dysuria etc. is demonstrate,proved.
Flos Farfarae: acrid in the mouth, hardship, warm in nature, enter lung meridian, there is nourishing the lung to arrest cough, the effect of the expectorant therapeutic method to keep the adverse QI flowing downwards, be mainly used in various coughing Coughing asthma, excessive phlegm and sputum mixed with blood etc. are demonstrate,proved.
Rhizoma Pinelliae Preparatum: acrid in the mouth, warm in nature, returns spleen, stomach, lung meridian, has effect of drying dampness to eliminate phlegm, cures mainly abundant expectoration cough, and wind-phlegm is dizzy Dizzy, syncope due to accumulation of phlegm headache etc. is demonstrate,proved.
Radix Angelicae Sinensis: latin name angelicae sinensis radix, sweet in the mouth, pungent, bitter, warm in nature, return liver, the heart, spleen channel, have Replenishing and activating blood, regulating menstruation relieves the pain, effect of loosening bowel to relieve constipation, and the head curing mainly deficiency of heart-blood is giddy, fatigue and weakness, shortness of breath and palpitation, and Other syndrome of deficiency of blood;The sea of blood is hollow, the cold and deficiency of CHONG and REN meridians or the menoxenia of congestion retardance, measures the cards such as phase of spreading out less.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, GUIXIN, Liver Channel, there is promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, supports Effect of blood and tranquilizing mind, cures mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, and skin infection swells and ache, vexed not Sleep;Hepatosplenomegaly, angina pectoris etc. is demonstrate,proved.
Radix Platycodonis: bitter in the mouth, pungent, slightly warm in nature, enter lung meridian, there is expelling phlegm for arresting cough, and have lung qi dispersing, evacuation of pus effect, cure mainly: cough expectorant Many, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis etc. are demonstrate,proved.
Radix Glycyrrhizae: sweet in the mouth, property puts down, enters 12 warps, have a heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, and the effect of expelling phlegm for arresting cough is, and can spleen invigorating In with, relieving spasm to stop pain, it is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak;Contracture pain in abdomen can be alleviated, relax some medicine Strong and the toxicity of thing, alleviate medicine to the toxic and side effects of body or to gastrointestinal stimulate, by add Radix Glycyrrhizae can play benefit Gas neutralizes, and is in harmonious proportion the effect of each component.
Pheretima: salty in the mouth, cold in nature, to return liver, spleen, bladder warp, there is heat clearing away arresting convulsion, dredging collateral is relievingd asthma, and effect of diuresis cures mainly height Hot coma, arthralgia, numb limbs and tense tendons, hemiplegia, lung-heat cough with asthma, effect of edema oliguria.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, hardship;Return spleen, lung meridian, pungent dissipate logical temperature, fragrant odour, be longer than and regulate the flow of vital energy, can enter spleen lung, therefore both Can manage it and dissipate sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gather around stagnant, chest and diaphragm feeling of fullness and stagnation of QI in spleen and stomach, distension and fullness in the abdomen etc. for lung qi and demonstrate,prove.
Exocarpium Citri Grandis: acrid in the mouth, hardship, warm in nature.Return lung, spleen channel, there is cold expelling, dampness, promoting the circulation of QI, effect of expectorant.For wind and cold The cards such as cough, itching of the throat abundant expectoration, food stagnation are got sick from drinking too much wine, jailbird is vexed.
Poria: sweet in the mouth, light, property is put down, is entered spleen, lung, bladder, heart channel, have eliminating dampness and diuresis, the effect of spleen invigorating mind calming, mainly use In the edema of retention of water-damp, dysuria;The pyretic stranguria of damp-heat accumulation, the stagnation of the anorexia and loose stool of stagnation of dampness due to deficiency of the spleen, phlegm retention, epilepsy etc. Card.
Gecko: salty in the mouth, property is put down, is returned lung, kidney channel, has invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, effect of supporing yang benefit essence, cures mainly lung Kidney deficiency, dyspnea due to deficiency tachypnea, chronic cough hemoptysis, sexual impotence, seminal emission etc. are demonstrate,proved.
Radix Astragali: latin name astragali radix, sweet in the mouth, warm in nature, return lung, spleen channel, have tonification spleen soil, rise and lift yang-energy, Strengthening superficial resistance to stop perspiration, torr skin ulcer granulation promoting etc. acts on, and is mainly used in treating the weak anorexia and loose stool that deficiency of both the splenic and pulmonary QI is caused, shortness of breath and palpitation, middle gas The visceroptosis sinking, the metrorrhagia of QI failing to control blood has blood in stool, chronic diarrhea proctoptosis;The spontaneous sweating of exterior deficiency;Insufficiency of vital energy and blood, decline of YANG QI Micro-skin infection does not rises, difficulty in discharging of pus, burst do not hold back for a long time;And the edema of deficiency of vital energy mistake fortune, dysuria etc. is demonstrate,proved.
Cortex Mori: latin name mori cortex, sweet in the mouth, cold in nature, enter lung meridian, there is eliminating pathogen from the lung for relieving asthma, the work of inducing diuresis to remove edema With, for one of the common drug of eliminating the pathogens from the lung row water, it is mainly used in the strongly fragrant lung of pathogenic heat, dyspnea with rapid respiration and cough that QI rising in reverse order does not drops, excessive phlegm, yellow skin, expectorant Stopping in drink, the distension cough with dyspnea that breast sun is not declared, Lung Qi obstraction, steam do not walk to edema dyspnea with fullness of the chest, dysuria, function of gallbladder promoting, promote the production of body fluid, eliminating stagnation Deng card.
Hirudo: salty in the mouth, hardship, property is put down, is entered Liver Channel, have effect of removing blood stasis, for blood stasis amenorrhea, lump in the abdomen stomachache, storage The treatment of the diseases such as blood, traumatic blood stasis are had a pain, carbuncle erysipelas, Hirudo can eliminate and raise plaque tremulous pulse week, increases myocardial nutrition Blood flow, improves arrhythmia.
Herba Ephedrae: acrid in the mouth, micro-hardship, warm in nature, enter lung, bladder warp, there is diaphoresis cold expelling, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema, For affection of exogenous wind-cold, fever with aversion to cold, head, body pain, nasal obstruction, lossless, the exterior excess syndrome such as floating and tense pulse, the exterior tightened by pathogenic windcold, sluggishness of lung-QI institute The card of breathing with cough caused.
Placenta Hominis: sweet in the mouth, salty, warm in nature, there is the kidney invigorating and essence nourishing, the effect of invigorating qi and benefiting blood, for for deficiency of kidney-QI, essence and blood Void is lost, impotence and seminal emission, soreness of waist tinnitus, or infertile;Deficiency of both the lung and kidney, dyspnea and shortness of breath;Insufficiency of vital energy and blood, few food of becoming thin, fatigue and asthenia, or Puerperal, breast waited card less.
Radix Bupleuri: latin name bupleuri radix, for umbelliferae bupleurum or the dry root of Radix Bupeuri Scorzonerfolii., bitter in the mouth, property Be slightly cold, return Liver Channel, gallbladder meridian, have evacuation bring down a fever, effect of yang invigorating soothing liver-QI, for cold, fever, alternate attack of chill and fever, malaria, stagnation of liver-QI The stagnation of QI, sternal rib pain, proctoptosis, the cards such as uterus comes off, menoxenia.
Colla Corii Asini: sweet in the mouth, property are flat, enter lung, liver, kidney channel, have tonifying blood and arresting bleeding, nourshing Yin and drynsessmoistening prescription effect, can be used for various asthenia The shallow complexion of symptom, especially blood deficiency, thin and weak weak, the head is dizzy, palpitation and insomnia;Malnutritional anemia, platelet subtracts Few property purpura;Deficient property hemoptysis;Haematemesis hematuria is had blood in stool;The cough dry pharynx of lung-dryness syndrome due to deficiency of YIN, sputum mixed with blood;Pathogenic heat lingering, deficiency of YIN blood The symptom such as consumption, the spasm of muscles and vessels of stirring-up of pathogenic wind in the interior resulting from deficiency, tetany, Colla Corii Asini has the erythrocytic generation of promotion, increases blood calcium concentration, promotees Enter the effect of hemostasis, and contribute to strengthening the immunologic function of human body.
Semen Armeniacae Amarum: bitter in the mouth, warm in nature, enter lung, large intestine channel, there is expelling phlegm for arresting cough, relieving asthma, effect of intestine moistening.Cure mainly exogenous cough, Dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation etc. is demonstrate,proved.
Radix Rubiae: cold in nature, bitter in the mouth, return Liver Channel, effect: cooling blood for hemostasis;Blood circulation promoting and blood stasis dispelling, cures mainly: heat in blood is spat blood;Spit blood;Epistaxis; Hematuria;Have blood in stool;Metrorrhagia;Amenorrhea;Postpartum stagnation is suffered from abdominal pain;Traumatic injury;Rheumatic arthralgia;Jaundice;Carbuncle sore;Hemorrhoid swollen the most just.
Herba Cirsii: sweet in the mouth, hardship, cool in nature, GUIXIN, Liver Channel, there is cooling blood for hemostasis, effect of removing blood stasis to reduce swelling, for epistaxis, tell Blood, hematuria, to have blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus etc. is demonstrate,proved.
Cortex Lycii: latin name Lycii Cortex, cold in nature, sweet in the mouth, there is removing heat from blood except steaming, effect of lung heat clearing pathogenic fire reducing, cure mainly Deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis etc. are demonstrate,proved.
Radix Cynanchi Atrati: bitter in the mouth is salty, cold in nature, enter lung, stomach, kidney channel, there is the effect of clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, detoxification sore treatment, use In heating disease, especially it is suitable for the card such as fever due to yin deficiency, deficiency-heat in puerperal, also for pyretic stranguria, stranguria with blood, sore and toxic, laryngopharynx swelling and pain etc. Card.
Described Chinese medicine preparation technique routinely adds adjuvant and makes tablet, capsule, granule, the watered pill, micropill, dispersion Sheet, oral cavity disintegration tablet, pill or oral liquid, be preferably prepared to oral liquid.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, comprising:
The first step, take by weight Radix Glehniae, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae, Herba Dendrobii, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Pheretima, Pericarpium Citri Reticulatae, Exocarpium Citri Grandis, Gecko, Radix Astragali, Hirudo, Placenta Hominis, Radix Bupleuri, Semen Armeniacae Amarum, Cortex Lycii and Radix Cynanchi Atrati are cleaned respectively, pulverize, mixing Together, adding Colla Corii Asini further, being subsequently added the determining alcohol mixing quality of medicinal material 8~10 times amount obtained relative to this step is 80%~90% ethanol, heating and refluxing extraction 3 times, each 1~2 hour, united extraction liquid;The extracting solution recovered under reduced pressure second of gained Alcohol, is concentrated into 0.5g crude drug/ml, is 1.5~4 with acid for adjusting pH, lets cool, and filters, and on filtrate, resin volume is equivalent to crude drug medicine Liquid amasss the macroporous resin column of 2~4 times, first rinses with 1~1.5 times of cylinder hydrops, and water lotion discards, then with 2~3 times of column volumes Determining alcohol be 85~95% ethanol elution, collect eluent, eluent is evaporated to extractum, 60 DEG C of vacuum drying, taking-up, Pulverize, it is thus achieved that powder;
Second step, cleans remainder crude drug component respectively, is mixed in proportion, and is preceded by stating 3-5 times of medical material gross weight Soak by water 2 hours, filter, filtering residue adds the soak by water 1.5 hours of 3-5 times of above-mentioned medical material gross weight again, filters, merging 2 decoction liquor, filter, and when being concentrated into 70 DEG C, relative density are 1.05, are cooled to room temperature, add dehydrated alcohol, make medicinal liquid Containing alcohol volume is 70%, stirs evenly, and stands 24 hours, takes supernatant, and after reclaiming ethanol, when being concentrated into 60 DEG C, relative density is 1.25 extractum;
The extractum mixing that 3rd step, the powder first step obtained and second step obtain, adds corresponding adjuvant, is prepared as Corresponding dosage form.
When being prepared as oral liquid, described 3rd step is specially the powder first step obtained further and second step obtains Extractum mixing, add water to 500ml, heated and stirred, to being completely dissolved, is subsequently added 3.0g steviosin, stirring so that it is the most molten Solving, after cooling, add ethyl hydroxybenzoate 0.5g, add water and adjust to 950ml, regulation pH value, to 6.6-7.0, stands 24 hours; 4800rpm is centrifuged 20 minutes, takes supernatant, and the adjustment total amount that adds water, to 1000ml, stirs evenly, subpackage, 100 DEG C of flowing steam sterilizations 30 Minute.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 oral liquid 1
Weigh Radix Glehniae 30g, Radix Ginseng 15g, Radix Ophiopogonis 30g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae 30g, Herba Dendrobii 30g, Radix Angelicae Sinensis 25g, Radix Salviae Miltiorrhizae 15g, Pheretima 10g, Pericarpium Citri Reticulatae 15g, Exocarpium Citri Grandis 10g, Gecko 25g, Radix Astragali 25g, Hirudo 8g, Placenta Hominis 15g, Radix Bupleuri 12g, Semen Armeniacae Amarum 8g, Cortex Lycii 15g and Radix Cynanchi Atrati 12g clean respectively, pulverize, mix, and are subsequently added Colla Corii Asini 10g, add the alcohol of 3kg Concentration is 90% ethanol, heating and refluxing extraction 3 times, each 2 hours, united extraction liquid;The extracting solution decompression recycling ethanol of gained, Being concentrated into 0.5g crude drug/ml, be 3 with acid for adjusting pH, let cool, filter, on filtrate, resin volume is equivalent to crude drug medicine liquid volume 4 times Macroporous resin column, first rinse with 1.5 times of cylinder hydrops, water lotion discards, then is 90% ethanol with the determining alcohol of 3 times of column volumes Eluting, collects eluent, and eluent is evaporated to extractum, 60 DEG C of vacuum drying, takes out, and pulverizes, it is thus achieved that powder, by Rhizoma Polygonati Odorati 20g, Bulbus Fritillariae Thunbergii 12g, Fructus Trichosanthis 15g, Folium Eriobotryae (processed) 15g, Radix Asteris 15g, Flos Farfarae 15g, Rhizoma Pinelliae Preparatum 12g, Radix Platycodonis 12g, Radix Glycyrrhizae 20g, Poria 30g, Cortex Mori 15g, Herba Ephedrae (processed) 9g, Radix Rubiae 15g, Herba Cirsii 15g clean respectively, mixing, first add the soak by water 2 of 900g Hour, filtering, filtering residue adds the soak by water 1.5 hours of 900g again, filters, merges 2 decoction liquor, filtration, and is concentrated into 70 DEG C time relative density be 1.05, be cooled to room temperature, add dehydrated alcohol, making medicinal liquid containing alcohol volume is 70%, stirs evenly, and stands 24 hours, taking supernatant, after reclaiming ethanol, when being concentrated into 60 DEG C, relative density is the extractum of 1.25, previously obtained powder and Extractum mixes, and adds water to 500ml, and heated and stirred, to being completely dissolved, is subsequently added 3.0g steviosin, stirring so that it is fully dissolve, After cooling, adding ethyl hydroxybenzoate 0.5g, add water and adjust to 950ml, regulation pH value, to 7.0, stands 24 hours;4800rpm from The heart 20 minutes, takes supernatant, and the adjustment total amount that adds water, to 1000ml, stirs evenly, subpackage, 100 DEG C of flowing steam sterilizations 30 minutes.
Embodiment 2 oral liquid 2
Weigh Radix Glehniae 30g, Radix Ginseng 15g, Radix Ophiopogonis 30g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae 30g, Herba Dendrobii 25g, Radix Angelicae Sinensis 25g, Radix Salviae Miltiorrhizae 15g, Pheretima 5g, Pericarpium Citri Reticulatae 15g, Exocarpium Citri Grandis 10g, Gecko 20g, Radix Astragali 25g, Hirudo 5g, Placenta Hominis 10g, Radix Bupleuri 12g, Semen Armeniacae Amarum 6g, Cortex Lycii 10g and Radix Cynanchi Atrati 10g clean respectively, pulverize, mix, be subsequently added Colla Corii Asini 10g, add 3kg's Determining alcohol is 90% ethanol, heating and refluxing extraction 3 times, each 2 hours, united extraction liquid;The extracting solution recovered under reduced pressure second of gained Alcohol, is concentrated into 0.5g crude drug/ml, is 3 with acid for adjusting pH, lets cool, and filters, and on filtrate, resin volume is equivalent to crude drug medicine liquid volume The macroporous resin column of 4 times, first rinses with 1.5 times of cylinder hydrops, and water lotion discards, then is 90% with the determining alcohol of 3 times of column volumes Ethanol elution, collects eluent, and eluent is evaporated to extractum, 60 DEG C of vacuum drying, takes out, and pulverizes, it is thus achieved that powder, by jade Bamboo 15g, Bulbus Fritillariae Thunbergii 12g, Fructus Trichosanthis 15g, Folium Eriobotryae (processed) 10g, Radix Asteris 15g, Flos Farfarae 10g, Rhizoma Pinelliae Preparatum 10g, Radix Platycodonis 12g, raw sweet Grass 20g, Poria 25g, Cortex Mori 10g, Herba Ephedrae (processed) 6g, Radix Rubiae 10g, Herba Cirsii 10g clean respectively, and mixing first adds the decocting of 900g Boiling 2 hours, filter, filtering residue adds the soak by water 1.5 hours of 900g again, filters, merges 2 decoction liquor, filtration, and is concentrated into When 70 DEG C, relative density is 1.05, is cooled to room temperature, adds dehydrated alcohol, and making medicinal liquid containing alcohol volume is 70%, stirs evenly, quiet Putting 24 hours, take supernatant, after reclaiming ethanol, when being concentrated into 60 DEG C, relative density is the extractum of 1.25, previously obtained powder Mixing with extractum, add water to 500ml, heated and stirred, to being completely dissolved, is subsequently added 3.0g steviosin, stirring so that it is the most molten Solving, after cooling, add ethyl hydroxybenzoate 0.5g, add water and adjust to 950ml, regulation pH value, to 7.0, stands 24 hours;4800rpm Centrifugal 20 minutes, taking supernatant, the adjustment total amount that adds water, to 1000ml, stirs evenly, subpackage, 100 DEG C of flowing steam sterilizations 30 minutes.
Embodiment 3 oral liquid 3
Weigh Radix Glehniae 35g, Radix Ginseng 20g, Radix Ophiopogonis 35g, Fructus Schisandrae Chinensis 15g, Radix Rehmanniae 35g, Herba Dendrobii 30g, Radix Angelicae Sinensis 30g, Radix Salviae Miltiorrhizae 20g, Pheretima 10g, Pericarpium Citri Reticulatae 20g, Exocarpium Citri Grandis 15g, Gecko 25g, Radix Astragali 30g, Hirudo 8g, Placenta Hominis 15g, Radix Bupleuri 15g, Semen Armeniacae Amarum 8g, Cortex Lycii 15g and Radix Cynanchi Atrati 12g clean respectively, pulverize, mix, be subsequently added Colla Corii Asini 15g, add 3.5kg Determining alcohol be 90% ethanol, heating and refluxing extraction 3 times, each 2 hours, united extraction liquid;The extracting solution recovered under reduced pressure of gained Ethanol, is concentrated into 0.5g crude drug/ml, is 3 with acid for adjusting pH, lets cool, and filters, and on filtrate, resin volume is equivalent to crude drug medicinal liquid body The macroporous resin column of long-pending 4 times, first rinses with 1.5 times of cylinder hydrops, and water lotion discards, then with the determining alcohol of 3 times of column volumes is 90% ethanol elution, collects eluent, and eluent is evaporated to extractum, 60 DEG C of vacuum drying, takes out, and pulverizes, it is thus achieved that powder, By Rhizoma Polygonati Odorati 20g, Bulbus Fritillariae Thunbergii 15g, Fructus Trichosanthis 20g, Folium Eriobotryae (processed) 15g, Radix Asteris 20g, Flos Farfarae 15g, Rhizoma Pinelliae Preparatum 12g, Radix Platycodonis 15g, Radix Glycyrrhizae 25g, Poria 30g, Cortex Mori 15g, Herba Ephedrae (processed) 9g, Radix Rubiae 15g, Herba Cirsii 15g clean respectively, mixing, first add the water of 1kg Decocting 2 hours, filter, filtering residue adds the soak by water 1.5 hours of 1kg again, filters, merges 2 decoction liquor, filtration, and concentrates Being 1.05 to relative density when 70 DEG C, be cooled to room temperature, add dehydrated alcohol, making medicinal liquid containing alcohol volume is 70%, stirs evenly, Standing 24 hours, take supernatant, after reclaiming ethanol, when being concentrated into 60 DEG C, relative density is the extractum of 1.25, previously obtained powder End and extractum mix, and add water to 500ml, and heated and stirred, to being completely dissolved, is subsequently added 3.0g steviosin, stirring so that it is fully Dissolving, after cooling, add ethyl hydroxybenzoate 0.5g, add water and adjust to 950ml, regulation pH value, to 7.0, stands 24 hours; 4800rpm is centrifuged 20 minutes, takes supernatant, and the adjustment total amount that adds water, to 1000ml, stirs evenly, subpackage, 100 DEG C of flowing steam sterilizations 30 Minute.
Embodiment 4 toxicology detects
Rat acute toxicity test
Because the medicine that invention formulation treatment pneumosilicosis is used, more suitably administering mode is oral administration, therefore The toxicologic study of invention formulation uses gastric infusion mode to carry out.
Laboratory animal: cleaning grade Wistar rat, 40, male and female half and half.Test preposition animal in indoor adaptation environment 1 In week, freely ingest and take the photograph water, room temperature 24 ± 2 DEG C, relative humidity 40 ± 2%, illuminating light and shade round the clock and replace.
Experimental drug: oral liquid 1 gavage of the embodiment of the present invention 1 preparation, 3 times/day, making crude drug concentration is 0.95g/ Ml, 4 DEG C of preservations, standby, during use, constant temperature is to 24 DEG C.
Experimental technique: according to table of random number, rat is divided into matched group and experimental group, and (the gavage embodiment of the present invention 1 is made Standby oral liquid 1, is prepared as crude drug concentration 0.95g/ml, is equivalent to crude drug amount 57g/kg/d).Gavage amount is 20ml/kg, comparison Group gavage distilled water 20ml/kg.Successive administration 7 days, drug withdrawal is observed 3 days.Record rat body weight, take food, drinking-water situation, record fill The every reaction of rat after stomach, the every physiological reaction of phase rat between gavage, and death condition.
Result and conclusion: studied by acute toxicological experiment, observe situation after 7 days rat oral gavages, before gastric infusion, each group The weight of animals, take food, situation of drinking water no difference of science of statistics, after gastric infusion, each group rat body weight change, feed drinking-water situation, No difference of science of statistics., there is not death and other toxic reactions in behavioristics's Non Apparent Abnormality.This experimental group dosage (crude drug concentration 57g/kg/d), being 136.8 times of clinical adult medication, modern pharmacology is thought, tests for Acute toxicity, maximum resistance to Be equivalent to the clinical daily dosage of people more than 100 times by amount and animal without death, when occurring without overt toxicity response situation, this medicine is Safety.Verified by this acute toxicity test, non-toxic reaction, it can be assumed that, the medication of this clinical drug is safe.
Rat chronic toxicity test of the present invention
Being studied by acute toxicity test, be administered clinical human 136.8 times of invention formulation have no side effect, in clinic Pneumosilicosis treatment needs to carry out the most long-term treatment, it is therefore desirable to carry out long_term toxcity experimentation, verifies that it is with or without accumulation poison Property or the change of delayed toxicity, particularly internal organs.
The same acute toxicity test of laboratory animal, experimental drug.
Experimental technique: according to table of random number, is divided into matched group and high dose group (the gavage embodiment of the present invention 1 by rat Preparation oral liquid 1, be prepared as crude drug concentration 0.55g/ml, be equivalent to crude drug amount 33g/kg/d), low dose group (gavage this The oral liquid 1 of bright embodiment 1 preparation, is prepared as crude drug concentration 0.35g/ml, is equivalent to crude drug amount 21g/kg/d).Gavage amount is 20ml/kg, matched group gavage distilled water 20ml/kg.Successive administration 60 days, drug withdrawal is observed 14 days.Record rat body weight, feed, Drinking-water situation, the every reaction of rat after record gavage, the every physiological reaction of phase rat between gavage, and death condition.
Result and conclusion: in experiment, high low dosage is respectively 33g/kg/d, 21g/kg/d, corresponding adult intends consumption clinical day 79.2 times, 50.4 times, after successive administration 60d, by comparing every Testing index with matched group, such as general state, body weight, enter A no difference of science of statistics respectively organized by appetite, amount of drinking water.By each group of rat is carried out histopathology relative analysis, have no obvious Toxicity sensitive indicator and toxicity target organ.After drug withdrawal observes 2 weeks, the every Testing index of high and low dose group rat all belongs to normal, not See Delayed onset toxic reaction and cumulative toxicity reaction.Comprehensive each group long term toxicity test result, gavage mixture of the present invention is applied To rat without obvious toxic-side effects, clinical adult's plan dosage and be in safety range the course for the treatment of.Therefore corresponding Clinical practice 60d In the course for the treatment of, it is also in safety range.
Embodiment 5 clinical data
Physical data
All cases totally 186 example, is this institute Respiratory Medicine outpatient.It is randomly divided into treatment group and matched group, two groups Ratio 1: 1.In treatment group 93 example, male 53 examples, female 40 example: age 26~68 years old, average 36.84 ± 15.18 years old, the course of disease 33 months ~28 years, average 19.87 ± 14.51 years, in matched group 93 example, male 55 examples, female 38 example: age 27~69 years old, average 38.15 ± 15.17 years old, the course of disease 36 months~27 years, average 18.64 ± 13.84 years.The basic datas such as two groups of sexes, age, courses of disease compare No significant difference (P > 0.05), has comparability.
Inclusion criteria
Western medicine diagnose standard
With reference to People's Republic of China's Occupational sanitary standard " pneumoconiosis diagnostic criteria " (GBZ70-2009), Li Dehong Chief editor's " Occupational Therapist's training material ".
Pneumoconiosis X-ray rabat is by stages
(1) one phase pneumoconiosis: have the small opacities of overall closeness 1 grade, distribution is at least up to 2 Ge Fei districts;
(2) two phase pneumoconiosis: have the small opacities of overall closeness 2 grades, distribution is more than 4 Ge Fei districts;Or have the most intensive Spending the small opacities of 3 grades, distribution reaches 4 Ge Fei districts;
(3) three phase pneumoconiosis: have an one of following three performance:
1. having big shade to occur, its major diameter is not less than 20mm, and minor axis is not less than 1Omm;
2. having the small opacities of overall closeness 3 grades, distribution is more than 4 Ge Fei districts and has small opacities to assemble;
3. having the small opacities of overall closeness 3 grades, distribution is more than 4 Ge Fei districts and has big shade.
Tcm diagnosis standard
The People's Republic of China's traditional Chinese medicine industry standard " Chinese medical disease issued for 1994 with reference to State Administration of Traditional Chinese Medicine Standardization of diagnosis and curative effect " "guide to clinical practice with medical record" write of " Diagnostics of Chinese Medicine " and Qing Dynasty's doctor's YE Tian shi.Pneumoconiosis is returned by we Belong to traditional Chinese medical science lung-QI stagnation syndrome category, primary symptom: uncomfortable in chest, feel suffocated, cough, cough up phlegm, the pain over the chest and back, disease of holding concurrently: breathe hard, pant, sweating, spiritlessness and weakness.
Exclusion standard
The most all do not meet inclusive criteria, it is impossible to judge or the full person of observations;
2. merge severe cardiac, liver. the primary disease person such as kidney and blood system;
3. suffer from the disease patients such as severe digestive ulcer, diabetes, tuberculosis;
4. x-ray shows that obvious pulmonary infection, heating body temperature reach more than 38 DEG C persons;
5. to Chinese medicine allergy sufferers.
Reject case standard
1. after entering group, find that patient does not meets inclusive criteria or the person that meets exclusion standard;
2. during observing there is some serious Complications or the trend of deterioration in patient, need to add and use antibiotic;
With hormone or other treatment measure person;
3. patient compliance is poor, uses medicine not reach the 80% of ormal weight;
4. cannot adhere to therapist because of a variety of causes.
Therapeutic Method
All patients totally 186 examples are randomly divided into treatment group and matched group, take following therapeutic scheme respectively.
Treatment group: give and the oral liquid 1 of the embodiment of the present invention 1 preparation, 50ml/ time, 2 times/day, oral, taking medicine after meal sooner or later With, within 1 month, it is a course for the treatment of.
Matched group: pseudoephedrine hydrochloride solution is administered orally, and 10ml/ time, 3 times/day, 1 month be a course for the treatment of.
Observation index and the standard of curative effect evaluation
Cough symptom score
In the daytime cough symptom score and nocturnal cough's symptom score: 0 point, without cough;1 point: be interrupted of short duration cough;2 points: frequently Numerous cough slight effect routine work and life;3 points: frequently cough and have a strong impact on routine work and life.Two groups in controlling Each survey 1 time before and after treatment.
This special cough quality of life questionnaire (LCQ) scoring of laser
Scoring by the way of inquiry, 19 every all marks by 1~7 point, and the lowest score of life quality is more Low.Calculate total score (TS) and always divide equally (TMS), two groups of each survey 1 times before and after treatment.
Laboratory and auxiliary examination
1. gait test in 6 minutes;2. pulmonary function test
Safety detects
Observe the untoward reaction in therapeutic process, and detect routine blood test, routine urinalysis, stool routine examination, hepatic and renal function.
Curative effect determinate standard
1. control: symptom and sign disappears or substantially disappears, and other objective determination index is normal, therapeutic index >= 90%;
The most effective: sings and symptoms is obviously improved, other objective determination index is normal, therapeutic index >=60%;
The most effective: sings and symptoms has alleviated, but inconspicuous, other objective determination index has an improvement, and therapeutic index >= 30%;
The most invalid: sings and symptoms is without changing or increasing the weight of, and other objective determination index has no improvement, therapeutic index < 30%.
Note: therapeutic index computing formula (nimodipine method) is: therapeutic index=(integration after integration-treatment before treatment)/ Integration X100% before treatment
Statistical method
Use SPSS16.0 statistics software that data is processed.Enumeration data represents with rate (%), compares and adopt between group Use χ2Inspection;Measurement data is with mean ± standard deviationRepresent, between group, compare employing t inspection.
Result
Cough symptom score
Through the treatment of a course for the treatment of, cough symptom score in the daytime and nocturnal cough's symptom score the most all declines for two groups, control Treatment group declines relatively matched group and becomes apparent from, difference statistically significant (P < 0.05), is shown in Table 1.
1 liang of table group cough symptom score changes and compares
Note: compare between two groups*P < 0.05;Compare before and after treatment#P < 0.05.
LCQ marks
Through treatment in 2 weeks, two groups of LCQ scorings were improved, and treatment group TS and TMS raise and be relatively better than matched group, and difference has system Meaning (P < 0.05) learned by meter, is shown in Table 2.
The group LCQ scoring of 2 liang of table changes and compares
Note: compare between two groups*P < 0.05;Compare before and after treatment#P < 0.05.
Clinical efficacy
Through treatment in 2 weeks, treatment group Chinese medicine syndrome integral improvement rate was better than matched group, statistically significant (the P < of difference 0.05) 3, it are shown in Table.
3 liang of table group Clinical efficacy comparison
Group Number of cases Control Effective Effectively Invalid Total effective rate
Treatment group 93 23 34 33 3 96.77%*
Matched group 93 14 29 39 11 88.17%
Note: compare between two groups*P < 0.05.
Gait test in 6 minutes
Table gait test in 46 minutes
Note: compare between two groups*P < 0.05;Compare before and after treatment#P < 0.05
Pulmonary function test
Table 5 lung function
Note: compare between two groups*P < 0.05;Compare before and after treatment#P < 0.05
Untoward reaction
During treatment in 2 weeks, all patients are all without obvious adverse reaction, and Liver and kidney function, blood, urine and stool routine check all without bright Aobvious ANOMALOUS VARIATIONS.
By clinical and experimental study, Chinese medicine preparation of the present invention had well for stages such as silicotic's chronic fibrosis of lung Therapeutical effect, the improvement result for patient is better than matched group, illustrates that its clinical effectiveness is notable, it is adaptable to clinical application.
Embodiment 6 animal experiment study
Laboratory animal
Kunming mouse, Wistar rat, Japan large ear rabbit, male and female dual-purpose.
Instrument and reagent
Phenol red fasten extra large three Ai Si reagent company limiteies and produce;Oleum Terebinthinae is fastened perfumery, sea and is produced;Ammonia fastens seaization Work two factory produces;Dimethylbenzene (content > 99.0%) it is that Solution on Chemical Reagents in Shanghai company of Chinese Medicine (group) company produces;Injection Ampicillin is fastened extra large four medicine company limiteies and is produced.Medical Equipment Plant of Jiading District in Shanghai City of laryngeal spray system produces;Frontal mirror Fasten Hai Yiyongtingzhenqichang to produce;721 spectrophotometers are fastened sea the 3rd analytical tool factory and are produced;Hai Tian fastened by electronic balance Flat instrument plant produces;Shanghai Surgical Operation Equipment Factory of centrifuge system produces;Olympus optical microscope is produced by Japan.
Medicine
The oral liquid 1 of the embodiment of the present invention 1, being prepared as containing crude drug concentration is 0.55g/ml, slow pharynx oxazepan granule (lactose Type, every bag of 5g, suitable crude drug 3.6g);Guilong Medicine Co., Ltd., Shanxi produces, and faces the used time and is configured to distilled water the denseest Degree (every milliliter contains former medicine 0.38 gram) is for experiment.Aspirin: Shanghai nine good fortune pharmaceutcal corporation, Ltd produces.Face the used time to steam Distilled water is configured to 0.95% concentration for experiment.
Experimental technique
Antiinflammatory action is observed
Mice auricle swelling Inhibition test
Select body weight 23~25g mice, male and female dual-purpose, be randomly divided into two groups.Matched group gavage normal saline, invention group fills The oral liquid 1 of the stomach embodiment of the present invention 1 preparation, 0.1ml/10g body weight, for three days on end.1h after being administered for 4th day, wide in mouse right ear Positive and negative melted paraxylene 2, after 30min, mice is put to death in dislocation of cervical vertebra, cuts two ears along auricle baseline, punches at same position Device is laid auricle (diameter 9mm) and is weighed.Represent inflammatory swelling degree with the difference of two auricle weight, between organizing t inspection, and by with Lower formula obtains the inhibitory rate of intumesce of Chinese medicine preparation group of the present invention.Average swelling-the administration of inhibitory rate of intumesce (%)=matched group Organize average average swelling × 100% of swelling/matched group
Rat granuloma Inhibition test
Select body weight 130~160g male and healthy rat, divide 4 groups at random, respectively normal saline (NS) matched group, invention Group and aspirin (AS) group.Abdominal incision is made, in the subcutaneous each embedment 30 of both sides groin under ether light anaesthesia aseptic condition The aseptic cotton balls of ± 1mg 1, adds ampicillin 1mg/0.1ml with front each cotton balls, and 50 DEG C of baking ovens are done.Preoperative 1h and postoperative ig It is administered, continuous 7 days.Last is administered the neck that breaks of rat after 1h and puts to death, and peels off and takes out cotton balls granulation tissue, puts into 60 DEG C of oven dryings 4h.Weigh after taking-up, deduct raw cotton ball weight and be granuloma dry weight.Calculate and relatively respectively organize average granuloma weight/100g body Weight.
The observation of Chinese medicine preparation activating QI to eliminate phlegm effect of the present invention
The experiment of mice trachea PSP
Select body weight 25~30g healthy mice, be randomly divided into 2 groups.It is respectively saline control group, invention group.After administration 0.5h only injects 5% phenol red solution 0.5ml/, and after 0.5h, mice is put to death in dislocation of cervical vertebra, cuts off center skin, separates trachea, larynx Lower enter tracheal strips about 0.3cm with polish No. 7 syringe needle skewers, after ligation is fixing, draw 2.24mmol/L bicarbonate with 1ml syringe Sodium 0.5ml, lavation respiratory tract 3 times, inject color comparison tube by irrigating solution back and forth.Operate 3 times by upper method, rinse 9 times altogether.Merge lavation Liquid, is centrifuged off float, takes supernatant 721 spectrophotometric colo (wavelength 546mm).Standard curve checks in lavation Corresponding phenol red content (g) in liquid.Respectively group trachea section phenols contents.
Chronic pharyngitis animal model observation of curative effect
Body weight 2~2.5kg Japan large ear rabbit, male and female dual-purpose.It is randomly divided into normal group, modeling group and invention group.Set up Chronic pharyngitis animal model.Except normal group, other two groups of every days spray pharyngeal twice with 2.5% ammonia, pressing 3 times every time, the 8th day Pharyngeal submucosal injection Oleum Terebinthinae 0.3ml, and continue to spray ammonia to the 15th day.Modeling group and invention group every natural gift from the 1st day Other gavage distilled water and Chinese medicine preparation of the present invention, continuous 10 days.Normal group only gavage distilled water every day.Three treated animals were on 2nd Paraffin embedding, section, dyeing, take pharyngeal after om observation femoral artery sacrificed by exsanguination, medium-sized formalin is fixed, conventional right The histological appearance of each group sample is analyzed.Additionally, note observing animal appearance, activity, feed, periodically during Shi Yan Weigh, the next day perusal pharyngeal Mucosa Morphology of each treated animal, color and luster, secretions etc..
Result
The antiinflammatory action of Chinese medicine preparation of the present invention
The Chinese medicine preparation of the present invention impact on mice auricle swelling
Observing on the mice auricle swelling model made of dimethylbenzene, Chinese medicine preparation of the present invention substantially suppresses mouse ear Wide swelling, its inhibitory rate of intumesce reaches 49.69%.Result shows, Chinese medicine preparation of the present invention can substantially resist caused by dimethylbenzene little Mus auricle inflammatory edema.
The impact on mice auricle swelling of table 6 Chinese medicine preparation of the present invention
Group n Auricle swelling degree (mg) Inhibitory rate of intumesce (%)
Matched group 13 15.9±5.1
Invention group 13 7.9±4.3 50.31
The impact that rat granuloma is swollen by Chinese medicine preparation of the present invention
Observing on rat granuloma swells model, Chinese medicine preparation of the present invention substantially suppresses granuloma to grow, granuloma Suppression ratio exceedes aspirin group.
The impact that rat granuloma is swollen by table 7 Chinese medicine preparation of the present invention
Compare with matched group,*P < 0.05, compares with aspirin group,#P<0.05
The observation of Chinese medicine preparation activating QI to eliminate phlegm effect of the present invention
The Chinese medicine preparation of the present invention impact on mice trachea PSP
It was experimentally observed that at mice PSP, Chinese medicine preparation of the present invention makes phenols contents increase respectively, with reference to dispelling Expectorant medicine drug effect criterion, is effective to increase by 1 times than matched group.
The impact on mice trachea PSP of table 8 Chinese medicine preparation of the present invention
Group N Phenols contents (μm/ml) Excretion increases percentage ratio (%)
Matched group 10 2.7±0.8
Invention group 10 7.3±1.3 270.37*
Compare with matched group,*P<0.05
The Chinese medicine preparation of the present invention impact on rat plasma euglobulin lysis time (BLT)
Finding in rat plasma euglobulin lysis time test experience, Chinese medicine preparation of the present invention can substantially shorten ELT.
The impact on rat plasma euglobulin lysis time of table 9 Chinese medicine preparation of the present invention
Group n Euglobulin lysis time (is divided)
NS matched group 8 1201.4±10.1
Invention group 8 105.9±11.9*
Compare with matched group,*P<0.05
The Chinese medicine preparation of the present invention observation to treatment of chronic pharyngitis effect
Observing on rabbit chronic pharyngitis model, the modeling a few days, major part animal activity reduces, more, feed of drinking water Amount slightly reduces, and body weight slightly declines.Pharynx rear wall mucosa is congested, Mild edema.Injection Oleum Terebinthinae after 1~2 day, feed subtract greatly, individually Occurring panting or dyspnea, pharyngeal edema is obvious, general persistently spontaneous remission after 2~3 days.Chinese medicine preparation treatment group of the present invention Symptom is slightly light, recovers slightly fast, and mirror hypopharynx tissue morphologic observation result shows, Chinese medicine preparation treatment group inflammatory reaction of the present invention is light In matched group (table 10).
Table 10 each treated animal pharyngeal form compares
Compare with matched group,*P < 0.05, compares with modeling group,#P<0.05
By the experimentation of Chinese medicine preparation of the present invention, it has preferable therapeutical effect for pneumosilicosis chronic injury, right There is good improvement result in chronic inflammatory disease etc., establish laboratory basis for clinical experiment.
All above-mentioned primary these intellectual properties of enforcement, do not set this new product of enforcement limiting other forms And/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar execution feelings Condition.But, all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc. Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.

Claims (8)

1. the Chinese medicine preparation being used for treating pneumosilicosis, it is characterised in that: crude drug includes Radix Glehniae, Radix Ginseng, Radix Ophiopogonis, the five tastes Son, Radix Rehmanniae, Herba Dendrobii, Rhizoma Polygonati Odorati, Bulbus Fritillariae Thunbergii, Fructus Trichosanthis, Folium Eriobotryae (processed), Radix Asteris, Flos Farfarae, Rhizoma Pinelliae Preparatum, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Radix Platycodonis, life Radix Glycyrrhizae, Pheretima, Pericarpium Citri Reticulatae, Exocarpium Citri Grandis, Poria, Gecko, Radix Astragali, Cortex Mori, Hirudo, Herba Ephedrae (processed), Placenta Hominis, Radix Bupleuri, Colla Corii Asini, Fructus Pruni Core, Radix Rubiae, Herba Cirsii, Cortex Lycii and Radix Cynanchi Atrati.
2. the Chinese medicine preparation for treating pneumosilicosis as claimed in claim 1, it is characterised in that: the weight of each crude drug is respectively Radix Glehniae 25g~35g, Radix Ginseng 15g~20g, Radix Ophiopogonis 25g~35g, Fructus Schisandrae Chinensis 10g~15g, Radix Rehmanniae 30g~35g, Herba Dendrobii 25g~35g, Rhizoma Polygonati Odorati 15g~20g, Bulbus Fritillariae Thunbergii 10g~15g, Fructus Trichosanthis 15g~20g, Folium Eriobotryae (processed) 10g~15g, Radix Asteris 15g~ 20g, Flos Farfarae 10g~20g, Rhizoma Pinelliae Preparatum 10g~15g, Radix Angelicae Sinensis 20g~30g, Radix Salviae Miltiorrhizae 15g~20g, Radix Platycodonis 10g~15g, raw sweet Grass 15g~25g, Pheretima 5g~10g, Pericarpium Citri Reticulatae 15g~20g, Exocarpium Citri Grandis 10g~15g, Poria 25g~30g, Gecko 20g~30g, Radix Astragali 20g~30g, Cortex Mori 10g~20g, Hirudo 5g~8g, Herba Ephedrae (processed) 6g~10g, Placenta Hominis 10g~15g, Radix Bupleuri 10g ~15g, Colla Corii Asini 10g~15g, Semen Armeniacae Amarum 6g~10g, Radix Rubiae 10g~15g, Herba Cirsii 10g~15g, Cortex Lycii 10g~15g, Radix Cynanchi Atrati 10g~15g.
3. the Chinese medicine preparation for treating pneumosilicosis as claimed in claim 1 or 2, it is characterised in that: the weight of each crude drug is divided Not Wei Radix Glehniae 30g~35g, Radix Ginseng 15g~20g, Radix Ophiopogonis 30g~35g, Fructus Schisandrae Chinensis 10g~15g, Radix Rehmanniae 30g~35g, Herba Dendrobii 25g~30g, Rhizoma Polygonati Odorati 15g~20g, Bulbus Fritillariae Thunbergii 12g~15g, Fructus Trichosanthis 15g~20g, Folium Eriobotryae (processed) 10g~15g, Radix Asteris 15g~20g, Flos Farfarae 10g~15g, Rhizoma Pinelliae Preparatum 10g~12g, Radix Angelicae Sinensis 25g~30g, Radix Salviae Miltiorrhizae 15g~20g, Radix Platycodonis 12g~ 15g, Radix Glycyrrhizae 20g~25g, Pheretima 5g~10g, Pericarpium Citri Reticulatae 15g~20g, Exocarpium Citri Grandis 10g~15g, Poria 25g~30g, Gecko 20g~25g, Radix Astragali 25g~30g, Cortex Mori 10g~15g, Hirudo 5g~8g, Herba Ephedrae (processed) 6g~9g, Placenta Hominis 10g~ 15g, Radix Bupleuri 12g~15g, Colla Corii Asini 10g~15g, Semen Armeniacae Amarum 6g~8g, Radix Rubiae 10g~15g, Herba Cirsii 10g~15g, Cortex Lycii 10g ~15g, Radix Cynanchi Atrati 10g~12g.
4. the Chinese medicine preparation for treating pneumosilicosis as described in claims 1 to 3, it is characterised in that: the weight of each crude drug is divided Wei Radix Glehniae 30g, Radix Ginseng 15g, Radix Ophiopogonis 30g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae 30g, Herba Dendrobii 30g, Rhizoma Polygonati Odorati 20g, Bulbus Fritillariae Thunbergii 12g, Fructus Trichosanthis 15g, Folium Eriobotryae (processed) 15g, Radix Asteris 15g, Flos Farfarae 15g, Rhizoma Pinelliae Preparatum 12g, Radix Angelicae Sinensis 25g, Radix Salviae Miltiorrhizae 15g, Radix Platycodonis 12g, Radix Glycyrrhizae 20g, Pheretima 10g, Pericarpium Citri Reticulatae 15g, Exocarpium Citri Grandis 10g, Poria 30g, Gecko 25g, Radix Astragali 25g, Cortex Mori 15g, Hirudo 8g, Herba Ephedrae (processed) 9g, Placenta Hominis 15g, Radix Bupleuri 12g, Colla Corii Asini 10g, Semen Armeniacae Amarum 8g, Radix Rubiae 15g, Herba Cirsii 15g, Cortex Lycii 15g, Radix Cynanchi Atrati 12g。
5. the Chinese medicine preparation for treating pneumosilicosis as described in Claims 1-4, it is characterised in that: described Chinese medicine preparation is by often Rule technique adds adjuvant and makes tablet, capsule, granule, the watered pill, micropill, dispersible tablet, oral cavity disintegration tablet, pill or oral liquid Body preparation.
6. the Chinese medicine preparation for treating pneumosilicosis as described in claim 1 to 5, it is characterised in that: prepared by described Chinese medicine preparation Become oral liquid.
7. the preparation method of Chinese medicine preparation described in claim 1 to 6, it is characterised in that including:
The first step, take by weight Radix Glehniae, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae, Herba Dendrobii, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Pheretima, Pericarpium Citri Reticulatae, Exocarpium Citri Grandis, Gecko, Radix Astragali, Hirudo, Placenta Hominis, Radix Bupleuri, Semen Armeniacae Amarum, Cortex Lycii and Radix Cynanchi Atrati are cleaned respectively, pulverize, are blended in one Rise, be subsequently added Colla Corii Asini, add relative to this step obtain mixing quality of medicinal material 8~10 times amount determining alcohol be 80%~ 90% ethanol, heating and refluxing extraction 3 times, each 1~2 hour, united extraction liquid;The extracting solution decompression recycling ethanol of gained is dense Being reduced to 0.5g crude drug/ml, be 1.5~4 with acid for adjusting pH, let cool, filter, on filtrate, resin volume is equivalent to crude drug medicine liquid volume The macroporous resin column of 2~4 times, first rinses with 1~1.5 times of cylinder hydrops, and water lotion discards, then pure and strong with 2~3 times of column volumes Degree is 85~95% ethanol elution, collects eluent, and eluent is evaporated to extractum, 60 DEG C of vacuum drying, takes out, pulverizing, Obtain powder;
Second step, cleans remainder crude drug component respectively, is mixed in proportion, and is preceded by stating the water of 3-5 times of medical material gross weight Decocting 2 hours, filter, filtering residue adds the soak by water 1.5 hours of 3-5 times of above-mentioned medical material gross weight, filtration again, merges 2 times Decoction liquor, filters, and when being concentrated into 70 DEG C, relative density is 1.05, is cooled to room temperature, adds dehydrated alcohol, makes medicinal liquid containing alcohol Volume is 70%, stirs evenly, and stands 24 hours, takes supernatant, and after reclaiming ethanol, when being concentrated into 60 DEG C, relative density is 1.25 Extractum;
The extractum mixing that 3rd step, the powder first step obtained and second step obtain, adds corresponding adjuvant, is prepared as corresponding Dosage form.
8. the preparation method of Chinese medicine preparation as claimed in claim 7, it is characterised in that: when being prepared as oral liquid, the described 3rd Step is specially the extractum mixing of the powder first step obtained and second step acquisition further, adds water to 500ml, and heated and stirred is extremely It is completely dissolved, is subsequently added 3.0g steviosin, stirring so that it is fully dissolve, after cooling, add ethyl hydroxybenzoate 0.5g, add water Adjusting to 950ml, regulation pH value, to 6.6-7.0, stands 24 hours;4800rpm is centrifuged 20 minutes, takes supernatant, and add water adjustment Total amount, to 1000ml, stirs evenly, subpackage, 100 DEG C of flowing steam sterilizations 30 minutes.
CN201610334728.7A 2016-05-19 2016-05-19 Traditional Chinese medicine preparation for treating silicosis Pending CN105998725A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610334728.7A CN105998725A (en) 2016-05-19 2016-05-19 Traditional Chinese medicine preparation for treating silicosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610334728.7A CN105998725A (en) 2016-05-19 2016-05-19 Traditional Chinese medicine preparation for treating silicosis

Publications (1)

Publication Number Publication Date
CN105998725A true CN105998725A (en) 2016-10-12

Family

ID=57095948

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610334728.7A Pending CN105998725A (en) 2016-05-19 2016-05-19 Traditional Chinese medicine preparation for treating silicosis

Country Status (1)

Country Link
CN (1) CN105998725A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108014264A (en) * 2017-12-29 2018-05-11 缪荣明 It is a kind of to be used to treat oral traditional Chinese medicine preparation of silicosis and preparation method thereof
CN108030826A (en) * 2017-12-29 2018-05-15 缪荣明 A kind of Chinese medicinal capsule of auxiliary treatment silicosis and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102824568A (en) * 2011-06-19 2012-12-19 孙斌 Traditional Chinese medicine for treating silicosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102824568A (en) * 2011-06-19 2012-12-19 孙斌 Traditional Chinese medicine for treating silicosis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108014264A (en) * 2017-12-29 2018-05-11 缪荣明 It is a kind of to be used to treat oral traditional Chinese medicine preparation of silicosis and preparation method thereof
CN108030826A (en) * 2017-12-29 2018-05-15 缪荣明 A kind of Chinese medicinal capsule of auxiliary treatment silicosis and preparation method thereof

Similar Documents

Publication Publication Date Title
CN102772649A (en) Traditional Chinese medicine composition for treating chronic pharyngitis and preparation method thereof
CN104013868A (en) Traditional Chinese medicine composition for treating chronic obstructive pulmonary disease and preparation method thereof
CN103169883B (en) Traditional Chinese medicine for treating infantile jaundice
CN105998725A (en) Traditional Chinese medicine preparation for treating silicosis
CN105497723A (en) Traditional Chinese medicine preparation for treating bacterial pneumonia and preparation method thereof
CN104784549A (en) Traditional Chinese medicine for treating allergic rhinitis
CN104771578A (en) Traditional Chinese medicine for treating allergic rhinitis
CN103191331B (en) Traditional Chinese medicine composition for treating bronchial asthma in remission stage
CN101549059B (en) Medicament for treating bronchial asthma and preparation method thereof
CN103893737A (en) Medicament used for treating bronchial asthma and preparation method thereof
CN103182064A (en) Medicine for treating cough due to wind-cold evil and preparation method thereof
CN103393829B (en) Traditional Chinese medicine for treating pathogen wind impairing lung type cough
CN103028041B (en) Traditional Chinese medicine composition for treating acute nasosinusitis of children and preparation method of traditional Chinese medicine composition
CN104721573A (en) Traditional Chinese medicinal composition for treating phlegm-damp type chronic bronchitis
CN103191399A (en) Traditional Chinese medicine composition for treating bronchial asthma in acute-outbreak period
CN103893666B (en) A kind of medicine for the treatment of chronic bronchitis
CN103599253B (en) A kind of Chinese medicine composition being used for the treatment of old people&#39;s itch in winter
CN103041172B (en) Traditional Chinese medicine composition for curing chronic nasosinusitis and preparation method thereof
CN103041194B (en) Traditional Chinese medicine composition for curing chronic eczema and preparation method thereof
CN105749103A (en) Pharmaceutical preparation for treating narcolepsy and preparation method thereof
CN103212005B (en) Traditional Chinese medicine composition for treatment of wind-dryness cough
CN105233180A (en) Drug for treating internal hemorrhoid due to damp-heat pouring downward syndrome
CN101961453B