CN102614323B - Method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia - Google Patents

Method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia Download PDF

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CN102614323B
CN102614323B CN 201210117442 CN201210117442A CN102614323B CN 102614323 B CN102614323 B CN 102614323B CN 201210117442 CN201210117442 CN 201210117442 CN 201210117442 A CN201210117442 A CN 201210117442A CN 102614323 B CN102614323 B CN 102614323B
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陈祥胜
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Nantong Donghu International Travel Agency Co Ltd
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Abstract

The invention discloses a method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia. The atomized liquid comprises gleditsia fruit, loquat leaf, European hop flower, Chinese waxgourd semen, common bluebeard herb, platycodon root, red clover, whiteflower hogfennel root and borneol which serve as raw materials. The method is characterized by comprising the following steps of: (1) extracting the loquat leaf, the European hop flower and the common bluebeard herb by a supercritical fluid extraction method to obtain volatile oil; (2) crushing the gleditsia fruit and the borneol into superfine powder; (3) decocting the red clover, the whiteflower hogfennel root, the Chinese waxgourd semen and the platycodon root in water twice, filtering, mixing filtrates, and concentrating at the temperature of 80 DEG C until the relative density is 1.1 to obtain a water extracting solution; and (4) stirring the volatile oil obtained in the step (1), the superfine powder obtained in the step (2) and the water extracting solution obtained in the step (3) uniformly, standing at normal temperature for 12 hours, and filtering to obtain liquid medicine. Clinical experiments prove that the atomized liquid prepared by the method has an obvious treatment effect, and the hospital stays can be shortened.

Description

A kind of preparation method for the treatment of children's's ASP atomized liquid
Technical field
The present invention relates to nursing field in the institute, be specifically related to treat the preparation method of children's's ASP atomized liquid.
Background technology
ASP claims bronchiolitis again, is more common in children's below 2 years old, and is multiple with winter-spring season, is the common lower respiratory infection disease of infant.Main the causing a disease of ASP was virus originally, and RSV is the most common with respiratory syncytial virus.Rise and to show as cough after being ill, breathe heavily suppress, dyspnea, the extensive wheezing sound of pulmonary, severe patient generation cardiac insufficiency, respiratory failure.It breathes heavily outbreak basis and the pathological characteristics suppressed is airway inflammation and high response, mainly shows as inflammatory cell infiltration and epithelial cell damage based on eosinophilic granulocyte.Eosinophilic granulocyte is potent scorching preceding cell, and the cytokine IL-5 of activated T lymphocytes source property can make eosinophilic granulocyte increment and activation, discharges multiple toxic protein and inflammatory mediator, thereby causes airway epithelia damage and bronchial hyperreactivity.Also have data to show, the clinical and pathology of ASP has the performance of similar asthma.In ASP infant airway secretions and serum, find to have the peculiar inflammatory material of a large amount of similar asthma infants, as virus-specific IgE, histamine, arachidonic acid IL-4, IL-5, and these inflammatory materials can cause smooth muscle spasm, promote the secretion of air flue body of gland, increase the weight of myxedema, cause airway obstruction.Make airway epithelia impaired during respiratory tract infection, sensory nerve ending exposes, and causes the airway reactivity height, and macromolecular substances such as virus, antibacterial, chlamydia also constitute allergic basis as complete antigen effect body.Can infer that according to present result of study ASP is the clinical syndrome of infective inflammation and allergic inflammation and the complexity of depositing.
The present treatment of ASP is as long as for the routine treatment of relievining asthma, comprise application glucocorticoid, bronchodilator etc.But in fact have following problem: 1. etiological treatment deficiency was syncytial virus owing to cause a disease in airway inflammation reaction basis originally, and doctor trained in Western medicine is not at this viral specific drug at present; 2. the use of hormone uses hormone to have restriction on the clear and definite amount in the infant sufferer, and except the common adverse effect of hormone, children's's prolonged application hormone person because hormone has the effect of pair antigrowth hormone, can also cause that protein negative balance and then influence grow; 3. the life-time service of bronchodilator causes the reduction of beta 2 receptor sensitivity easily, causes the medicaments insensitive degree to descend.So at present clinically still lack effect certainly and the medicine of the treatment children's ASP that side effect is little.
Summary of the invention
Technical assignment of the present invention is at above the deficiencies in the prior art, and a kind of atomized liquid preparation method is provided, for the preparation of the atomized liquid of effect treatment children's ASP sure and easy to use.
The technical scheme that the present invention solves its technical problem is: a kind of preparation method for preparing above-mentioned treatment children's ASP atomized liquid, and described atomized liquid is made by Fructus Gleditsia, Folium Eriobotryae, Flos lupuli (Flos Humuli Lupuli), Semen Benincasae, Herba Caryopteridis Incanae, Radix Platycodonis, Herba Trifolii Pratentis, Radix Peucedani, Borneolum Syntheticum; It is characterized in that its preparation method is:
(1) gets Folium Eriobotryae, Flos lupuli (Flos Humuli Lupuli), Herba Caryopteridis Incanae pulverizing, take the extraction of supercritical extraction method, get volatile oil;
(2) get Fructus Gleditsia, Borneolum Syntheticum pulverizing, cross 200 mesh sieves, get micropowder;
(3) get Herba Trifolii Pratentis, Radix Peucedani, Semen Benincasae, Radix Platycodonis and decoct with water 2 times, filter, merging filtrate, 80 ℃ are concentrated into relative density 1.1, get the water extract;
(4) volatile oil of step 1 gained, the micropowder of step 2 gained are added the water extract of step 3 gained, stir, leave standstill 12 hours after-filtration under the room temperature and get medicinal liquid.
Wherein said: Fructus Gleditsia is the fruit of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..The nature and flavor suffering, temperature.Return lung; Large intestine channel.But merit expelling phlegm for arresting cough; Have one's ideas straightened out to lead to and close; The parasite killing eliminating stagnation.
Folium Eriobotryae is the dried leaves of rosaceous plant Folium Eriobotryae Eriobotrya japonica (Thunb.) Lindl..The nature and flavor hardship is slightly cold.Attach to the lung and stomach meridians.But the merit clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.
Flos lupuli (Flos Humuli Lupuli) is the green fruit ear of the immaturity of Moraceae humulus plants Flos lupuli (Flos Humuli Lupuli) Humulus lupulus L..Bitter in the mouth; Slightly cool in nature.Return liver; The stomach warp.But merit invigorating the stomach and promoting digestion; Inducing diuresis to remove edema; Anti-consumptive disease antiinflammatory.
Semen Benincasae, the seed of Cucurbitaceae herbaceous plant Fructus Benincasae Benincasahispida (Thumb.) Cogn..Nature and flavor are sweet, and are cold.Return spleen, stomach, large intestine, small intestine meridian.The function lung heat clearing, reduce phlegm, evacuation of pus.
Herba Caryopteridis Incanae is Verenaceae Herba Caryopteridis Incanae platymiscium Herba Caryopteridis Incanae Caryopteris incana (Thunb.) Miq. herb or root.Suffering, temperature.But the merit dispelling wind to relieve the exterior syndrome, expelling phlegm for arresting cough, the silt pain relieving of loosing.
Radix Platycodonis is campanulaceae Platycodon grandiflouorum Platycodon grandiflorum(Jacq.) dry root of A.DC..Nature and flavor hardship, suffering, flat.Return lung meridian.But the merit lung qi dispersing, sore-throat relieving eliminates the phlegm, evacuation of pus.。
Herba Trifolii Pratentis is inflorescence and the wounded in the battle branch and leaf of leguminous plant Herba Trifolii Pratentis Trifolium pratense L..Sweet in the mouth; Bitter; Cold nature.Return lung meridian.But merit clearing and antitussive; Mass dissipating and swelling eliminating.
Radix Peucedani is the dry root of samphire Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn or RADIX PEUCEDANI Peucedanum decursivum Maxim..Nature and flavor hardship, suffering are slightly cold.Return lung meridian.The merit wind heat clearing away of can loosing, lowering the adverse-rising QI to resolve phlegm.
Borneolum Syntheticum is the processed goods of Dipterocarpaceae plant Borneolum Syntheticum resin, or is the product of being processed into that Camphora, Lignum Pini Nodi wet goods synthesize with chemical method.Hot, bitter, be slightly cold.GUIXIN, spleen, lung meridian.The merit refreshment of can having one's ideas straightened out, clearing away heat to alleviate pain.
Composition principle: Chinese medicine thinks that ASP belongs to the pathogen being excessive but vital QI weak type, is because due to the obstruction of lung-QI, gluing of phlegm and heat.Modern medicine thinks that the ASP main pathogen is respiratory syncytial virus, and main pathological change is respiratory tract obstruction, and ventilation and dysfunction of ventilation cause anoxia, acidosis.To get the Fructus Gleditsia acrid in the mouth warm in nature in the side, goes into lung and large intestine two warps, the special waking up the patient from unconsciousness by clearing away phlegm of merit, and the energy of relieving constipation is arranged, and make the exterior and the interior unobstructed, lung qi must fall, the genus symptomatic treatment in acute condition.Folium Eriobotryae, Semen Benincasae, Herba Trifolii Pratentis lung heat clearing.Herba Caryopteridis Incanae is dispeled the wind cold, the Radix Peucedani wind heat of loosing, and the two is all controlled from table, and can expelling phlegm for arresting cough.Reduce phlegm.Folium Eriobotryae pancake lung qi, the Radix Platycodonis lung qi dispersing eliminates the phlegm, and one opens one closes the middle mechanism of qi that recovers lung qi.Other has Flos lupuli (Flos Humuli Lupuli) diuresis antiinflammatory, and the gas that draws phlegm-damp is descending.Borneolum Syntheticum has the merit of waking up the patient from unconsciousness by clearing away heat.
And modern study shows that Fructus Gleditsia, Radix Platycodonis, Radix Peucedani contain the composition of Saponin class, and secretion that can reflexive promotion respiratory mucus produces phlegm-dispelling functions; Triacanthine (Triacanthin) contained in the Fructus Gleditsia has the effect of papaverine sample, can treat bronchial asthma etc.Flos lupuli (Flos Humuli Lupuli) volatile oil can suppress the growth of gram-positive bacterium, tulase and syncytial virus, to gram negative bacteria unrestraint effect, Flos lupuli (Flos Humuli Lupuli) preserved material and volatile oil have powerful spasmolysis to the rabbit bronchial smooth muscle, and can antagonism the convulsion effect that causes of acetylcholine, barium chloride, its spasmolysis is direct relaxing smooth muscle, and more than effect may be relevant with its main component .beta.-bitter acid .alpha.-bitter acid, isovaleric acid.Herba Caryopteridis Incanae stimulates ammonia and causes that the mice of chronic tracheitis has antitussive action.Herba Trifolii Pratentis has an effect that suppresses paramecium external, also usefully eliminates the phlegm, spasmolysis to be to control pertussis and bronchitis person; Its pollen has antibacterial action to some gram negative bacilli.In addition, experimental results show that Folium Eriobotryae has good anti-allergic effects, it can fall IgE level total in the serum, stablizes mast cell membrane, suppresses it and takes off granule and medium release, reduces the thick sputum degree, improves ventilatory function, plays the lowering the adverse-rising QI to subdue asthma effect.And play a driving role improving humoral immunization, eliminate oxygen-derived free radicals and suppress aspects such as flow of calcium ions.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 3 parts in Fructus Gleditsia, 9 parts of Folium Eriobotryaes, 15 parts of Flos lupuli (Flos Humuli Lupuli)s, 15 parts of Semen Benincasaes, 9 parts of Herba Caryopteridis Incanaes, 9 parts of Radix Platycodoniss, 10 parts of Herba Trifolii Pratentiss, 6 parts of Radix Peucedanis, 1 part of Borneolum Syntheticum.
Embodiment 2, the crude drug weight proportion: 1 part in Fructus Gleditsia, 6 parts of Folium Eriobotryaes, 10 parts of Flos lupuli (Flos Humuli Lupuli)s, 10 parts of Semen Benincasaes, 6 parts of Herba Caryopteridis Incanaes, 6 parts of Radix Platycodoniss, 15 parts of Herba Trifolii Pratentiss, 9 parts of Radix Peucedanis, 3 parts of Borneolum Syntheticums.
Embodiment 3, the crude drug weight proportion: 2 parts in Fructus Gleditsia, 8 parts of Folium Eriobotryaes, 12 parts of Flos lupuli (Flos Humuli Lupuli)s, 12 parts of Semen Benincasaes, 8 parts of Herba Caryopteridis Incanaes, 8 parts of Radix Platycodoniss, 12 parts of Herba Trifolii Pratentiss, 8 parts of Radix Peucedanis, 2 parts of Borneolum Syntheticums.
The preparation process of embodiment 1 ~ 3 is as follows:
(1) gets Folium Eriobotryae, Flos lupuli (Flos Humuli Lupuli), Herba Caryopteridis Incanae pulverizing, take the extraction of supercritical extraction method, get volatile oil;
(2) get Fructus Gleditsia, Borneolum Syntheticum pulverizing, cross 200 mesh sieves, get micropowder;
(3) get Herba Trifolii Pratentis, Radix Peucedani, Semen Benincasae, Radix Platycodonis and decoct with water 2 times, filter, merging filtrate, 80 ℃ are concentrated into relative density 1.1, get the water extract;
(4) volatile oil of step 1 gained, the micropowder of step 2 gained are added the water extract of step 3 gained, stir, leave standstill 12 hours after-filtration under the room temperature and get medicinal liquid.
Effective combination of said medicine is coordinated mutually, effectively reach the purpose for the treatment of children's ASP, and side effect is less, and dosage form is easy to use rapid-action.The above results is that clinical data proves that fully interrelated data is as follows, wherein studies drug use and is the crude drug weight proportion among the embodiment 3.
1 object and method.
1.1 object: be in October, 2010 ~ 2011 year JIUYUE in my institute children's's ASP 70 examples of being in hospital, infant meets all that " pediatrics is about the ASP diagnostic criteria, and typing all can be discussed the standard of formulation with reference to 1987 year's harvest.3 months ~ 1 years old infant age, 8 months mean aves, have typical ASP clinical manifestation, complication such as apnea depletion, heart failure, and except disease such as congenital heart disease, foreign body in bronchus, pulmonary tuberculosis.The equal nutriture of each case is good, and blood glucose, blood fat and hepatic and renal function are all in normal range.
1.2 method.
1.2.1 ordinary circumstance: infant is divided into 2 groups at random: 39 examples are organized in treatment, male 20 examples, women 19 examples; Matched group 31 examples, male 17 examples, women 14 examples.2 groups of case loads, sex, age, course of disease comparing difference not statistically significant (P〉0.05), have comparability.
1.2.2 Therapeutic Method: matched group gives conventional therapy, keeps airway patency, infection, spasmolytic, eliminates the phlegm, processing such as cough-relieving.The treatment group adds with proportioning raw materials and preparation method gained atomized liquid 10ml in the embodiment of the invention 3 on the conventional therapy basis, adds normal saline 20ml, and the face shield that atomizes sucks.Every day 1 ~ 2 time, the courses for the treatment of 3 ~ 5 d.
1.2.3 observation of curative effect: observe and record respectively organize case breathe heavily suppress, cough, wheezing sound and length of stay.
1.2.4 safety evaluatio: all carry out monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after the medication.
1.2.5 statistical analysis: carry out statistical analysis with SPSS 11.0, the gained data are represented with mean ± standard deviation, row t check.P＜0.05 expression has the significance meaning.
2 results.
2.1 the treatment group is being breathed heavily the curative effect of suppressing, cough, wheezing sound regression time and length of stay and matched group compare, and difference has statistical significance (P＜0., 01).See the following form.
Group The example number Breathe heavily and suppress Cough Wheezing sound Length of stay
The treatment group 39 2.0±1.1 5.3±2.1 3.1±1.4 7.0±1.7
Matched group 31 3.7±1.8 7.1±2.8 5.1±1.0 8.5±2.2
The t value ? 4.8 3.0 6.7 3.2
The P value ? <0.01 <0.01 <0.01 <0.01
2.2 untoward reaction: the vital sign of infant (blood pressure, heart rate, body temperature, breathing), physical examination, blood biochemical analysis, electrocardiogram and routine urinalysis Non Apparent Abnormality during treating.
3. conclusion.
This paper 39 routine ASP infants suck with the atomized liquid atomizing of preparation method preparation of the present invention, and the result shows that observation group's therapeutic effect obviously is better than matched group, and the hospital stays shortens.In using atomization process, do not find untoward reaction, safer, be worth applying clinically.

Claims (3)

1. preparation method for preparing above-mentioned treatment children's ASP atomized liquid, it is characterized in that described atomized liquid crude drug weight proportion: 3 parts in Fructus Gleditsia, 9 parts of Folium Eriobotryaes, 15 parts of Flos lupuli (Flos Humuli Lupuli)s, 15 parts of Semen Benincasaes, 9 parts of Herba Caryopteridis Incanaes, 9 parts of Radix Platycodoniss, 10 parts of Herba Trifolii Pratentiss, 6 parts of Radix Peucedanis, 1 part of Borneolum Syntheticum; Its preparation method is:
(1) gets Folium Eriobotryae, Flos lupuli (Flos Humuli Lupuli), Herba Caryopteridis Incanae pulverizing, take the extraction of supercritical extraction method, get volatile oil;
(2) get Fructus Gleditsia, Borneolum Syntheticum pulverizing, cross 200 mesh sieves, get micropowder;
(3) get Herba Trifolii Pratentis, Radix Peucedani, Semen Benincasae, Radix Platycodonis and decoct with water 2 times, filter, merging filtrate, 80 ℃ are concentrated into relative density 1.1, get the water extract;
(4) volatile oil of step 1 gained, the micropowder of step 2 gained are added the water extract of step 3 gained, stir, leave standstill 12 hours after-filtration under the room temperature and get medicinal liquid.
2. preparation method for preparing above-mentioned treatment children's ASP atomized liquid, it is characterized in that described atomized liquid crude drug weight proportion: 1 part in Fructus Gleditsia, 6 parts of Folium Eriobotryaes, 10 parts of Flos lupuli (Flos Humuli Lupuli)s, 10 parts of Semen Benincasaes, 6 parts of Herba Caryopteridis Incanaes, 6 parts of Radix Platycodoniss, 15 parts of Herba Trifolii Pratentiss, 9 parts of Radix Peucedanis, 3 parts of Borneolum Syntheticums; Its preparation method is:
(1) gets Folium Eriobotryae, Flos lupuli (Flos Humuli Lupuli), Herba Caryopteridis Incanae pulverizing, take the extraction of supercritical extraction method, get volatile oil;
(2) get Fructus Gleditsia, Borneolum Syntheticum pulverizing, cross 200 mesh sieves, get micropowder;
(3) get Herba Trifolii Pratentis, Radix Peucedani, Semen Benincasae, Radix Platycodonis and decoct with water 2 times, filter, merging filtrate, 80 ℃ are concentrated into relative density 1.1, get the water extract;
(4) volatile oil of step 1 gained, the micropowder of step 2 gained are added the water extract of step 3 gained, stir, leave standstill 12 hours after-filtration under the room temperature and get medicinal liquid.
3. preparation method for preparing above-mentioned treatment children's ASP atomized liquid, it is characterized in that described atomized liquid crude drug weight proportion: 2 parts in Fructus Gleditsia, 8 parts of Folium Eriobotryaes, 12 parts of Flos lupuli (Flos Humuli Lupuli)s, 12 parts of Semen Benincasaes, 8 parts of Herba Caryopteridis Incanaes, 8 parts of Radix Platycodoniss, 12 parts of Herba Trifolii Pratentiss, 8 parts of Radix Peucedanis, 2 parts of Borneolum Syntheticums; Its preparation method is:
(1) gets Folium Eriobotryae, Flos lupuli (Flos Humuli Lupuli), Herba Caryopteridis Incanae pulverizing, take the extraction of supercritical extraction method, get volatile oil;
(2) get Fructus Gleditsia, Borneolum Syntheticum pulverizing, cross 200 mesh sieves, get micropowder;
(3) get Herba Trifolii Pratentis, Radix Peucedani, Semen Benincasae, Radix Platycodonis and decoct with water 2 times, filter, merging filtrate, 80 ℃ are concentrated into relative density 1.1, get the water extract;
(4) volatile oil of step 1 gained, the micropowder of step 2 gained are added the water extract of step 3 gained, stir, leave standstill 12 hours after-filtration under the room temperature and get medicinal liquid.
CN 201210117442 2012-04-20 2012-04-20 Method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia Active CN102614323B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103768408B (en) * 2014-01-30 2016-02-10 于守水 A kind of medicine preventing and treating anal and intestinal disease postoperative pain
CN103735868B (en) * 2014-01-30 2016-01-13 李磊 A kind of preparation method of anal and intestinal disease postoperative bag
CN103751489B (en) * 2014-01-30 2016-04-13 于宗光 A kind of preparation method for the treatment of the postoperative pain medication of neurosurgery
CN103948826A (en) * 2014-05-04 2014-07-30 侯向青 Aerosol inhalation solution used in preoperative period and preparation method thereof
CN104940621A (en) * 2015-05-27 2015-09-30 张传连 TCM atomizing agent for treating ventilator-associated pneumonia and nursing method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1686479A (en) * 2005-05-20 2005-10-26 北京正大绿洲医药科技有限公司 Loquat drip pill for treating cough and its preparation method
CN102327502A (en) * 2011-08-29 2012-01-25 刘晓娜 Chinese medicament capsule for treating tracheitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1686479A (en) * 2005-05-20 2005-10-26 北京正大绿洲医药科技有限公司 Loquat drip pill for treating cough and its preparation method
CN102327502A (en) * 2011-08-29 2012-01-25 刘晓娜 Chinese medicament capsule for treating tracheitis

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
任国华.小儿喘憋性肺炎的中医药治疗进展.《实用医技杂志》.2006,(第18期),第3202-第3204页.
兰香草挥发油化学成分的研究;陈红梅等;《井冈山师范学院学报》;20040630;第25卷(第6期);第5-8页 *
刘岩等.红车轴草的研究进展.《中草药》.2007,第38卷(第5期),附5-附8.
刘玉梅.啤酒花的化学成分及药理作用研究进展.《食品科学》.2009,第30卷(第23期),第521-527页.
啤酒花的化学成分及药理作用研究进展;刘玉梅;《食品科学》;20091215;第30卷(第23期);第521-527页 *
小儿喘憋性肺炎的中医药治疗进展;任国华;《实用医技杂志》;20061031(第18期);第3202页-3204页 *
曲柏超.浅谈冰片的药理研究与临床应用.《药物研究》.2012,(第2期),第30-31页.
浅谈冰片的药理研究与临床应用;曲柏超;《药物研究》;20120229(第2期);第30-31页 *
红车轴草的研究进展;刘岩等;《中草药》;20070531;第38卷(第5期);附5-附8 *
陈红梅等.兰香草挥发油化学成分的研究.《井冈山师范学院学报》.2004,第25卷(第6期),第5-8页.

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