CN113262289A

CN113262289A - Traditional Chinese medicine composition and preparation for treating nasal sinusitis and preparation method thereof

Info

Publication number: CN113262289A
Application number: CN202110552588.1A
Authority: CN
Inventors: 潘震东; 黄适
Original assignee: Individual
Current assignee: Individual
Priority date: 2021-05-20
Filing date: 2021-05-20
Publication date: 2021-08-17

Abstract

The invention relates to a traditional Chinese medicine composition for treating nose and nasosinusitis, a preparation and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-40 parts of ephedra, 20-35 parts of peony, 9-15 parts of asarum, 20-50 parts of dried ginger, 25-35 parts of liquorice, 25-40 parts of cassia twig, 15-20 parts of schisandra chinensis, 30-35 parts of pinellia ternate, 18-25 parts of grifola, 18-35 parts of poria cocos, 15-20 parts of bighead atractylodes rhizome, 25-30 parts of rhizoma alismatis, 20-35 parts of biond magnolia flower and 20-40 parts of cocklebur fruit. The invention has scientific formula, combines the medicines together, has the functions of relieving exterior syndrome and dispelling cold, warming lung and resolving fluid retention, has the advantages of less side effect, clinical effect and the like, and can effectively treat nose and nasosinusitis.

Description

Traditional Chinese medicine composition and preparation for treating nasal sinusitis and preparation method thereof

Technical Field

The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating nasal sinusitis, a preparation and a preparation method thereof.

Background

The 5 academic teams in the united states, 2004, combined the clinical guidelines for the development of nose and sinusitis in the journal of otorhinolaryngology and Neck surgery (Otolaryngol Head cock surg.2004; 131: S1-S62) and proposed the following definitions: chronic nasal and sinusitis is a group of conditions characterized by inflammation of the mucous membranes of the nose and sinuses, with a duration of symptoms above 12 weeks. The expert group decided to use the term rhinosinusitis (rhinosinusitis) instead of the former concept of sinusitis. The expert group also emphasizes that the concept of nose and sinusitis is absolutely different from that of rhinitis, which is an inflammation mainly confined to the nasal cavity. Approximately 3100 million people in the united states suffer from the disease annually, with an increasing incidence of disease year by year, and evidence suggests that the incidence of nasal and nasal sinusitis in the united states exceeds that of arthritis and hypertension. According to incomplete statistics, in large cities in China, the allergic rhinitis of children reaches 30% -40%, the symptoms of the nose and the nasosinusitis are mild, severe and unpredictable all the year round, and due to the multifactorial nature of the nose and the nasosinusitis and the complex etiology, the etiology of each patient cannot be clearly indicated at present. Not only is the cause of the disease complex, chronic nasal and nasal sinusitis often coexists with other diseases, such as allergic rhinitis, nasal polyps, cystic fibrosis, asthma, etc., and thus it is also believed that nasal and nasal sinusitis is a syndrome, not simply a disease.

Marx (1949) combined 10 autopsy pathology reports of 1627 cases, and found that macroscopic sinusitis was present in about 43% of the cases (i.e., 698 cases). Although most cases of the disease are so-called 'terminal sinusitis' which may appear due to extremely poor resistance before death, the disease incidence rate is high, and the generation of sinusitis is proved to be closely related to the health condition of the organism. Nasal and nasal sinusitis can have adverse effects on the physiological functions of the ear, the nasopharynx, the larynx, the trachea, the bronchi, the lungs and the digestive tract, and can be manifested as systemic symptoms: bad appetite, dysphoria, general malaise, aversion to cold, fever, insomnia, constipation, listlessness or lethargy, etc., and respiratory tract and digestive system symptoms such as cough, diarrhea, etc. may appear in children case; local symptoms are also manifested: nasal obstruction, watery nasal discharge, dysosmia, epistaxis, dizziness, hypomnesis, local pain, headache and other symptoms.

The traditional method for treating nasal and nasosinusitis diseases mainly comprises conservative treatment and operative treatment, wherein the conservative treatment mainly uses vasoconstrictor nasal drops and corticosteroid hormone to improve nasal cavity ventilation and drainage, or replacement therapy, namely negative pressure suction is used to enable liquid medicine to enter nasal sinuses, but the effect is poor, and the nasal and nasosinusitis diseases are easy to recur; nasosinusitis treatment operations such as microwave, laser and the like usually need to completely peel off mucosa of maxillary sinus, so that tissues in nasal cavities are carbonized and scabbed, the nasal cavities are difficult to recover, and even normal functions of the nasal cavities are damaged; the traditional operation has large wound, the patient is painful, the recovery period is long, and the patient needs to be observed in hospital; the traditional operation can only treat a single disease species, and the pathological tissues are easy to remain in the operation, so that a plurality of patients suffering from nose and nasosinusitis still cannot be cured even after the operation is carried out for a plurality of times.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a traditional Chinese medicine composition and a preparation capable of effectively treating nose and nasosinusitis and a preparation method thereof.

In order to realize the purpose of the invention, the invention provides a traditional Chinese medicine composition for treating nose and nasosinusitis, which comprises the following raw materials in parts by weight: 20-40 parts of ephedra, 20-35 parts of peony, 9-15 parts of asarum, 20-50 parts of dried ginger, 25-35 parts of liquorice, 25-40 parts of cassia twig, 15-20 parts of schisandra chinensis, 30-35 parts of pinellia ternate, 18-25 parts of grifola, 18-35 parts of poria cocos, 15-20 parts of bighead atractylodes rhizome, 25-30 parts of rhizoma alismatis, 20-35 parts of biond magnolia flower and 20-40 parts of cocklebur fruit.

Preferably, the traditional Chinese medicine composition for treating nose and nasosinusitis comprises the following raw materials in parts by weight: 30 parts of ephedra, 30 parts of Chinese herbaceous peony, 12 parts of asarum, 50 parts of dried ginger, 20 parts of liquorice, 30 parts of cassia twig, 12 parts of Chinese magnoliavine fruit, 30 parts of pinellia ternate, 18 parts of polyporus umbellatus, 18 parts of poria cocos, 18 parts of bighead atractylodes rhizome, 30 parts of rhizoma alismatis, 20 parts of biond magnolia flower and 20 parts of cocklebur fruit.

In order to realize the purpose of the invention, the invention also provides a preparation method of the traditional Chinese medicine decoction for treating nose and nasosinusitis, which comprises the following steps:

step A: first decocting, namely adding 150-180 g of the raw materials into 1000-4500 mL of water according to the total amount of the traditional Chinese medicine composition for treating nasal sinusitis according to the weight, carrying out first decoction, firstly decocting the raw materials with slow fire until decoction is boiled, then decocting the raw materials with strong fire for 10-15 min, and pouring out the decoction obtained by the first decoction;

and B: decocting for the second time: adding 1000-4500 mL of water again for second cooking, wherein the time of the second cooking is 1-2 hours; filtering the medicinal liquid;

and C: combining the decoction obtained by the first decoction and the second decoction by using a container with scales, concentrating and decocting, and concentrating to 120-150 mL;

step D: putting into a vessel while the solution is hot, and sealing with a rubber plug.

In order to realize the purpose of the invention, the invention also provides a traditional Chinese medicine decoction for treating nose and nasosinusitis, which is prepared by the preparation method.

In order to realize the aim of the invention, the invention also provides a preparation method of the oral paste for treating nose and nasosinusitis, which comprises the following steps:

step a: medicine soaking: according to the traditional Chinese medicine composition for treating the nose and the nasosinusitis, the raw materials are put into a container after being metered according to the total amount of 150-180 g, and then water is added into the container for soaking, wherein the water surface is 15-18 cm higher than the medicine surface, and the soaking time is about 18-20 hours;

step b: decocting: adding 4000mL of cold water into a container, boiling with strong fire, boiling with slow fire for about one hour, boiling with slow fire for 2.5-3.5 hours, wherein the medicinal liquid is gradually concentrated, and filtering the first medicinal liquid with gauze; repeating the above steps for three times, mixing the filtered decoctions, standing for precipitation, and filtering with four layers of gauze for 3 times;

step c: clear paste: decocting the decocted medicinal liquid on slow fire, evaporating for concentration, stirring with chopsticks or bamboo flat to prevent coking, gradually forming thick paste, dripping the concentrated medicinal liquid on dry paper with chopsticks or bamboo flat when it is hot, and stopping decocting when no water mark is found around the paste;

step d: collecting paste: adding adjuvants into the concentrated medicinal liquid, stirring until the gelatin block is completely melted, pouring into casserole, heating and stirring until the medicinal liquid drops to form line or column, adding precious fine material, and stirring to obtain soft extract;

step e: pouring the soft extract into a vessel quickly when the soft extract is hot.

The further technical proposal is that in the step b, the cocklebur fruit is fried in a steamed bun.

The further technical scheme is that in the step d, the auxiliary materials comprise at least one of sugar, glue and wine; the saccharide is at least one of flos Osmanthi Fragrantis Mel and xylitol, the gum is at least one of colla Corii Asini, colla Plastri Testudinis and colla Cornus Cervi, and the wine is yellow wine.

In order to realize the aim of the invention, the invention also provides an oral paste for treating nose and nasosinusitis, which is prepared by the preparation method.

Compared with the prior art, the invention can obtain the following beneficial effects:

the traditional Chinese medicine composition for treating the nose and the nasosinusitis, the preparation and the preparation method thereof can effectively treat the nose and the nasosinusitis, the traditional Chinese medicine composition has scientific formula, the effects of relieving exterior syndrome and dispelling cold, warming lung and dissolving drinking, less side effects, remarkable clinical effect and the like, is suitable for treating the nose and the nasosinusitis symptoms such as allergic rhinitis, nasosinusitis, frontal sinusitis, nasal polyps, hypertrophy of nasal turbinates and the like, is particularly suitable for treating the chronic nose and the nasosinusitis, can improve the general symptoms caused by the nose and the nasosinusitis, for example, can quickly relieve the symptoms such as poor appetite, dysphoria, discomfort of the whole body, chilly sensation, fever, insomnia, constipation, listlessness or somnolence and the respiratory tract and digestive system symptoms such as cough, diarrhea and the like in children cases, and can also quickly relieve the local symptoms caused by the nose and the nasosinusitis such as nasal obstruction, watery nasal discharge, olfactory disturbance, epistaxis, dizziness, and the like, Hypomnesis, local pain and headache.

Detailed Description

The traditional Chinese medicine composition for treating the nose and the nasosinusitis is mainly prepared by compounding a plurality of pure natural plant herbal traditional Chinese medicines such as ephedra, peony, asarum, dried ginger, liquorice, cassia twig, schisandra chinensis, pinellia ternate, polyporus umbellatus, poria cocos, bighead atractylodes rhizome, rhizoma alismatis, magnolia flower, cocklebur fruit and the like, and can remarkably play a synergistic effect under a certain dosage proportion, so that the traditional Chinese medicine composition has a good treatment effect on the nose and the nasosinusitis, and the medicine properties are direct and rapid. Wherein, the conventional pharmacology and action of each component are as follows:

herba ephedrae: the herba Ephedrae is a wind-cold-dispersing medicine in Chinese medicinal materials, is a plant of Ephedra of Ephedraceae, and has a height of about 20-40 cm; the wood stem is short or creeping. Pungent, slightly bitter and warm in nature. It enters lung meridian and bladder meridian. The main effects are sweating and relieving exterior syndrome, dispersing lung qi and relieving asthma, and inducing diuresis to alleviate edema. The Chinese language of Yunnan herbal medicine: it is indicated for cough due to obstruction of nasal orifice, smelly smell, and lung cold. The book of the book Jing: "Fengsheng, Shanghai headache, Wen malaria". Releasing exterior and sweating, eliminating pathogenic heat, relieving cough and reversing qi, removing cold and heat, breaking hardness and accumulating. "

Peony: radix Paeoniae is also called as isolated and isolated grass, and is a perennial herb of Paeoniaceae and Paeonia. Relieving spasm, relieving pain, dredging channels, and promoting urination, and can be used for treating female abdominal pain, stomach spasm, giddiness, gout, and diuresis. Modern pharmacological research of Chinese herbaceous peony: radix Paeoniae Rubra has antipyretic, analgesic, tranquilizing, spasmolytic, anticonvulsive, and pathogenic microorganism resisting effects. The record of Shen nong Ben Cao Jing: the medicine has bitter taste and no toxicity, and is mainly used for treating pathogenic qi abdominal pain, removing blood arthralgia, breaking hardness, accumulating cold and heat, relieving hernia and pain, promoting urination and tonifying qi. Inhibiting various fungi and viruses, improving cardiopulmonary function, and inhibiting delayed allergy.

Asarum: the asarum is also called asarum, etc. Has the functions of relieving exterior syndrome, dispelling cold, expelling wind, relieving pain, dredging orifices, warming lung and transforming fluid retention. It can be used for treating wind-cold type common cold, headache, toothache, rheumatalgia, nasosinusitis, and cough due to lung cold. As a medicinal plant, Asarum sieboldii is listed as the superior product in Shen nong's herbal Jing (Shen nong's herbal Jing). The New plains of materia Medica: as used herein, xi Xin can be used in a small amount but not in a large amount, or can be used in combination but not alone. It is used for many purposes to cause qi exhaustion and pain, and used alone to cause exhaustion of qi and death. As the yang-tonifying herbs of Xian Zi also ascend but do not sink, they can warm the fire in the kidney but not the water in the kidney. In the case of fire-type inflammation, the herb is not suitable for use in ears because it warms fire and causes the fire to rise. Or ask: is it effective to have headache in the adverse reaction of the essence of the people with the action of the essence? The head is the head of the six positive, and the head is fresh and cool when the clear qi rises and the turbid qi falls; but the ascending of turbid qi and the descending of clear qi lead to deep and painful eyes . Asarum herb, herba asari is clear but not turbid, so it is good at descending turbid qi and ascending clear qi, so it is indicated for headache as well. However, pungent flavor and property of the powder should be supplemented with blood-tonifying herbs to make qi flow into blood without dispersing. "

Dried ginger: the dried ginger is named as Baijiang, Yujiang and dried ginger, and is pungent in flavor and hot in nature and enters spleen, stomach, kidney, heart and lung meridians. Has the functions of warming spleen and stomach for dispelling cold, restoring yang and promoting blood circulation, and warming lung and resolving fluid retention. Can be used for treating abdominal psychroalgia, emesis, diarrhea, cold limbs, slight pulse, cough and asthma due to cold fluid retention. Compendium of materia Medica: gan Jiang can induce blood to enter blood system and qi to enter qi system. It is indicated for blood deficiency because it can remove aversion to nourishment new skin and has the meaning of growing yin from yang. It is also indicated for hematemesis, epistaxis and bleeding with yin and yang deficiency, and it is also indicated for heat-induced syndrome.

Licorice root: the liquorice belongs to Papilionaceae, and the roots and the rhizomes of the liquorice are medicinal parts of the liquorice, so that the liquorice can tonify qi and strengthen the middle warmer, relieve spasm and pain, moderate medicine property, moisten lung and eliminate phlegm to stop cough.

Cassia twig: gui Zhi belongs to the order of Cinnamomum camphora and is produced mainly in Guangxi, Guangdong and Yunnan provinces. Has effects of inducing sweat, expelling pathogenic factors from muscles, warming and dredging channels, supporting yang, regulating qi, and lowering qi. It is commonly used for wind-cold type common cold, abdominal cold pain, amenorrhea due to blood cold, arthralgia, phlegm and fluid retention, edema and palpitation. The compendium of materia Medica records: it is indicated for all wind-cold-damp, spasm and pain of bone joints, relieving muscular and muscular open of the striae, inhibiting liver qi, supporting spleen and earth, and treating yin-deficiency syndrome. "

Schisandra chinensis: fructus Schisandrae is dried mature fruit of Schisandra chinensis of Magnoliaceae. It is known as Bei Wu Wei Zi. Sour and sweet in flavor and warm in nature. Has the functions of astringing, inducing astringency, benefiting vital energy, promoting the production of body fluid, invigorating kidney and calming heart. Can be used for treating chronic cough, asthma, nocturnal emission, enuresis, frequent micturition, chronic diarrhea, spontaneous perspiration, night sweat, thirst due to body fluid consumption, internal heat, diabetes, palpitation, and insomnia. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): for the qi-tonifying syndrome, the lung governs all qi, and the acid can be recovered and enter the lung to tonify the lung, so it can also tonify qi. It is mainly indicated for cough with adverse rising qi, qi deficiency will block up without returning to original qi, sour qi will be recovered, qi is returned to original qi, and cough with adverse rising qi is removed . It can be used for treating fatigue, emaciation, deficiency, yin deficiency, and male sperm. "

Pinellia ternata: ban Xia is named as ban Xia Feng, Zhi Ye Lao and san Zhang Jue. Pungent taste and warm nature, with the actions of drying dampness and resolving phlegm, checking adverse rise of qi and arresting vomiting, relieving stuffiness and dissipating nodulation. Can be used for treating damp phlegm and cold phlegm, cough, asthma, excessive phlegm, phlegm retention, dizziness, palpitation, wind phlegm, vertigo, phlegm syncope, headache, emesis, regurgitation, feeling of fullness in chest and epigastrium, and globus hystericus; it is indicated for abscess with phlegm nodule. The book Jing: the recipe mainly comprises typhoid fever, chills and fever, heart downward hardness, qi descending, sore throat, dizziness, chest distension, coughing and borborygmus, and hidroschesis. "

And (3) polyporus umbellatus: polyporus, also named as wild boar dung, anemone rhizome, hoelen and ganoderma. It enters heart, spleen, stomach, lung and kidney meridians. It can induce diuresis and remove dampness. It is indicated for dysuria, edema, diarrhea, stranguria with turbid urine and leukorrhagia.

Tuckahoe, poria cocos: poria is also called Poria cocos, Poria peel and Poria cocos block, and is sweet and light in taste and neutral in nature. It enters heart, lung, spleen and kidney meridians. Has the effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart, and can be used for treating edema, oliguria, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia. The book materia Medica is as follows: the Chinese medicinal composition has the effects of inducing resuscitation and removing dampness, and inducing resuscitation and restoring heart and intelligence, and promoting the production of body fluid; removing dampness can expel water and dry spleen, strengthen middle-jiao and invigorate stomach; to treat epilepsy due to fright and thick intestine, it is indicated for phlegm and helps to descend. Because its taste is slightly sweet, it is said to tonify yang. But with less benefit and more profit. "

White atractylodes rhizome: warm in nature, sweet and bitter in taste. It enters spleen and stomach meridians. Has effects in invigorating spleen, invigorating qi, eliminating dampness, promoting diuresis, arresting sweating, and preventing miscarriage. They belong to the category of qi tonics under deficiency-tonifying herbs.

Rhizoma alismatis: rhizoma Alismatis is named as Shuizui, Ruyi flower, herba Asplenii Incisi. Has the effects of promoting diuresis, eliminating dampness, clearing heat, eliminating turbid pathogen and reducing blood fat. Can be used for treating dysuria, edema, abdominal distention, diarrhea, oliguria, phlegm retention, vertigo, pyretic stranguria, and hyperlipidemia. The book Ben Cao Hui Yan (treatise on materia Medica): the principal drugs of inducing diuresis. , commonly known as diuresis; danxi is also called as the action of benefiting the bladder and enveloping fire, if the bladder is enveloped with fire and is dysuria with retention and distention, fire purging will lead to water flow, while water flow will lead to fire lowering , so there is no conflict between water and fire. "

And (3) magnolia flower: flos Magnoliae is also named as flos Magnoliae and Magnolia liliflora. Has effects of dispelling pathogenic wind and cold, and relieving stuffy nose. It can be used for treating wind-cold type common cold, nasal obstruction, and nasosinusitis. Compendium of materia Medica: the lung opens into the nose, while the yangming stomach pulse goes upward around the nose, the brain is the house of spirit, and the nose is the orifice of the gate of life; when the middle-qi is deficient and the clear-yang is not ascending, the head is inclined and nine orifices are obstructed. The pungent flavor of Xin Yi can warm the middle energizer and treat head, face, eyes and nose diseases because it can help the stomach clear yang to move upward and go through the sky. "(this Jing Chang Shu": "the patient without the cold and heat of the five zang-organs and wind, headache and brain pain is the one who can not transform wind from yin on the yang icarius, but can not be treated by magnolia flower. The cold and heat in the five zang organs without wind and headache are the pathogens which are connected to the middle and the outer regions and do not pass through with yang-qi, and they are not treated by Xinyi. But wind-head and brain-pain are cold-heat in the five zang-organs, it is treated with Xin Yi. "

Fructus xanthil: cang Er Zi is distinguished by eight naked thorns, cang Lang Zi and Guangdong dialect are called Miscanthus sinensis (Rongman dementia). Belongs to Compositae and has effects of dispelling pathogenic wind, removing dampness and dredging orifices. Bitter, sweet and pungent in property and warm in nature. It enters lung and liver meridians. It can be used for treating wind-cold type common cold, nasosinusitis, rheumatalgia, rubella, pruritus, etc. The record of Shen nong Ben Cao Jing: the fructus xanthil is mainly used for treating wind-cold pain, rheumatism, periarthralgia, pain in limbs Luan, muscle and muscle wasting, knee pain and qi benefiting after long-term administration. "

The present invention will be described in further detail below by way of specific examples and comparative examples.

Example 1

The traditional Chinese medicine composition of the embodiment is prepared from the following raw materials in parts by weight: 15g of ephedra, 15g of peony, 6g of asarum, 25g of dried ginger, 10g of liquorice, 15g of cassia twig, 6g of schisandra chinensis, 15g of pinellia ternate, 9g of polyporus umbellatus, 9g of poria cocos, 9g of bighead atractylodes rhizome, 15g of rhizoma alismatis, 10g of biond magnolia flower and 10g of cocklebur fruit.

The preparation method of the traditional Chinese medicine composition for preparing the traditional Chinese medicine decoction comprises the following steps:

the method comprises the following steps: weighing the above materials, cleaning, pouring into a pot, and soaking in water for 30 min.

Step two: adding 1000-4500 mL of water for first cooking, firstly decocting with slow fire until the decoction is boiled, then decocting with strong fire for 10-15 min, and pouring out the decoction obtained by the first decoction.

Step three: and adding 1000-4500 mL of water again for second cooking, wherein the time of the second cooking is 1-2 hours by slow fire. Filtering the decoction.

Step four: and combining the decoction obtained by the first decoction and the second decoction by using a container with scales, concentrating and decocting, and concentrating to 120-150 mL.

Step five: putting into a vessel (such as a ceramic pot) while the solution is hot, and sealing with a rubber plug. The traditional Chinese medicine composition is decoction.

The administration method of the decoction of the embodiment comprises the following steps: the decoction is administered orally, 1 dose per day, 9 o 'clock in the morning for the first time, 3 o' clock in the afternoon for the second time, 7 days as a treatment course, and 2-3 treatment courses are continuously administered. Typical cases are: after a certain amount of Liu is cured, male and people in 39 years old and Nanning city feel stuffy nose, insomnia, dysphoria and constipation repeatedly for more than 5 years, the symptoms disappear after the traditional Chinese medicine compound decoction is used for 3 courses of treatment according to the medicine using method. And when the rest of the Chinese medicinal decoction is used for 3 courses of treatment, symptoms disappear.

Comparative example 1

The traditional Chinese medicine composition of the comparative example comprises the following raw materials in parts by weight: 20g of ephedra, 20g of peony, 10g of asarum, 30g of dried ginger, 15g of liquorice, 18g of cassia twig, 8g of schisandra chinensis, 18g of pinellia ternate, 15g of biond magnolia flower and 15g of cocklebur fruit.

The preparation method of the traditional Chinese medicine decoction prepared from the traditional Chinese medicine composition in the comparative example comprises the following steps:

Step two: decocting for the first time: and (3) adding 1000-4500 mL of water after metering for primary cooking, firstly decocting with slow fire until the decoction is boiled, then decocting with strong fire for 10-15 min, and pouring out the decoction obtained by primary decoction.

Step three: and adding 1000-4500 mL of water again for second cooking, wherein the time of the second cooking is 1-2 hours. Filtering the decoction.

The medication method of the decoction of the comparative example comprises the following steps: the decoction is orally taken for administration, 1 dose is taken every day, the first time is taken at 9 o 'clock in the morning, the second time is taken at 3 o' clock in the afternoon, 7 days are taken as a treatment course, and 3-4 treatment courses are continuously taken. Typical cases are: after a certain Wang, a woman in 48 years old and Mashan county suffer from repeated nasal obstruction, headache and memory decline for 5 years, the symptoms are improved after the Chinese medicinal composition is used for 4 courses of treatment according to the administration method. Tan Yi (male, 27 years old, river pool city people), repeated nasal obstruction, snoring and running nose for half a year, and the symptoms are improved after the Chinese medicinal composition is used for 1 course of treatment according to the administration method.

Comparative example 2

The traditional Chinese medicine composition of the comparative example comprises the following raw materials in parts by weight: 18g of ephedra, 18g of peony, 12g of asarum, 30g of dried ginger, 12g of liquorice, 18g of cassia twig, 9g of schisandra chinensis, 18g of pinellia ternate, 12g of biond magnolia flower, 12g of cocklebur fruit and 10g of polyporus umbellatus.

The medication method of the decoction of the comparative example comprises the following steps: the decoction is orally taken for administration, 1 dose is taken every day, the first time is taken at 9 o 'clock in the morning, the second time is taken at 3 o' clock in the afternoon, 7 days are taken as a treatment course, and 3-4 treatment courses are continuously taken. Typical cases are: when a certain plum is in a certain age, female, 28 years old, people in Heilongjiang province, repeat nasal obstruction, insomnia and memory decline for 3 years, the symptoms are relieved after the Chinese medicinal composition is used for 4 courses of treatment according to the administration method. In a certain prescription, men and people of 53 years old in Nanning city repeatedly have nasal obstruction and running nose for 20 years, and the symptoms are improved and relieved after the Chinese medicinal composition is used for 3 courses of treatment according to the administration method.

The following tests were carried out on the Chinese medicinal decoction obtained in the above example 1, comparative example 1 and comparative example 2:

randomly screening 60 patients with nasal sinusitis, wherein the subjects are all patients with chronic nasal sinusitis for a long time, and then randomly dividing the patients into three groups: the first group totals 20 persons, wherein 11 men and 9 women are 20-50 years old; a second group of 20 people in total, wherein 8 men and 12 women are 21-50 years old; the third group totals 20 people, 13 men and 7 women, aged 25-55 years.

The test method comprises the following steps: the experiment lasts for 21 days (three treatment courses), and the subjects keep normal diet during taking the medicine, so that the medicine is not applicable to other medicines for treating nose and nasosinusitis. The first group of subjects took the traditional Chinese medicine according to the traditional Chinese medicine decoction prepared in example 1 every day, the second group of subjects took the traditional Chinese medicine according to the traditional Chinese medicine decoction prepared in comparative example 1 every day, and the third group of subjects took the traditional Chinese medicine according to the traditional Chinese medicine decoction prepared in comparative example 2 every day.

And (3) test results: after the three courses of treatment were completed, the subjects were observed and the results are shown in table 1 below. Wherein "cure" in table 1 means that no symptoms of nasal sinusitis appear within 6 months after the medicament is stopped; "symptom relief" means that after the medicine is stopped, nasal obstruction, rhinorrhea and other nasal and nasal sinusitis symptoms still exist in the morning, and the symptoms are aggravated in cold air and rainy days; by "symptom not significantly alleviated" is meant that no significant clinical effect is seen or symptoms of nasal and nasal sinusitis remain. And the subject was subjected to CT review, the results of which are shown in table 2 below. Wherein "cure" in table 2 means that after the drug is stopped, the nasal CT flat scan and enhancement are reviewed after 3 months to show that no nose and nasosinusitis exist; the symptom relieving means that after the medicine is stopped, the CT flat scan and the enhancement of the nasal part are rechecked after 3 months to show that the nose and the nasosinusitis still exist in a certain nasal sinus; the 'symptom is not obviously relieved' means that the nasal CT flat scan and the enhancement are rechecked after 3 months after the medicine is stopped, so that the nasosinusitis still exists.

TABLE 1 Pre-and post-experimental rhinitis symptoms in Subjects

Grouping	Total number of tested persons	The number of people cured	Symptom relief	The number of people who do not have significant relief of symptoms
					First group	20	19	1	0
Second group	20	10	5	5
					Third group	20	13	6	1

Table 2 shows statistics of nasal CT flat scan and enhanced display results before and after experiment of subjects

Grouping	Total number of tested persons	The number of people cured	Symptom relief	The number of people who do not have significant relief of symptoms
					First group	20	18	2	0
Second group	20	9	6	5
					Third group	20	11	7	2

Example 2

The preparation method of the oral paste prepared from the traditional Chinese medicine composition of the embodiment is as follows:

the method comprises the following steps: preparing auxiliary materials: saccharides: flos Osmanthi Fragrantis Mel (oral paste for diabetes patients can be replaced by xylitol); and (3) glue: colla Corii Asini, colla Plastri Testudinis, and colla Cornus Cervi; wine: yellow wine. The use amount of the auxiliary materials such as saccharides, gums and the like can be selected according to the requirement. The points of attention for paste collection: for people with deficiency of yin and blood, colla Corii Asini and colla Plastri Testudinis can be used; colla Cornus Cervi can be used for treating yang deficiency; for deficiency of both yin and yang, colla Plastri Testudinis and colla Cornus Cervi can be used; mel can be used for patients with constipation; sugar is avoided for diabetic patients, and xylitol can be used to replace sugar; the patients with liver diseases can not be soaked with yellow wine. The standard of the paste formula is no burnt odor, peculiar smell and sugar-free crystal precipitation. The colla Corii Asini or other jelly must be smashed before being added into the paste, and soaked in yellow wine for dissolving.

Step two: medicine soaking: the traditional Chinese medicine composition is fully put into an earthen pot, and then a proper amount of warm water is added into the earthen pot for soaking, wherein the water is generally 15-18 cm higher than the medicine surface, and the soaking time is about 18-20 hours.

Step three: decocting: decocting the composition with fire (fructus Xanthii wrapped decocting), adding 4000mL cold water into a casserole container, boiling with strong fire, boiling with slow fire for about one hour, turning to slow fire to boil for about three hours, wherein the decoction is gradually concentrated, filtering the first decoction with gauze, repeating the above steps for three times, mixing the filtered decoctions, standing for precipitation, and filtering with four layers of gauze for 3 times to reduce impurities in the liquid medicine as much as possible.

Step four: clear paste: decocting the decocted medicinal liquid on slow fire, evaporating for concentration, stirring with chopsticks or bamboo flat to prevent coking, gradually forming thick paste, and dripping the concentrated medicinal liquid on dry paper with chopsticks or bamboo flat when it is hot until no water mark is seen around the paste. This is called clear paste.

Step five: collecting paste: adding adjuvants into the concentrated medicinal liquid, stirring until the gum blocks are completely melted, pouring into casserole, and stirring until the medicinal liquid drops to form line or column. For example, the paste is obtained by adding colla Corii Asini, colla Plastri Testudinis, colla Cornus Cervi, and appropriate amount of Mel into the thick paste, decocting with slow fire, and stirring with chopsticks. If other fine and noble materials exist, then adding the noble fine materials, and fully stirring to obtain the soft extract.

Step six: and (3) storage: the storage container is preferably a porcelain jar or a glass bottle, and the soft extract can be quickly poured into a special container which is cleaned and disinfected in advance. One material for the earthen jar and one material for the glass bottle, and 4-6 bottles. The pot and pot which can not be used for metal can be stored to avoid causing chemical reaction. The action of subpackaging the soft extract is required to be fast, otherwise, the viscous soft extract is easy to be condensed together, and the storage environment needs to be cool and dry (such as a refrigerator). One ointment formula is prepared for 4 weeks without much time for mildewing.

The composition is taken as a formula: the ointment formula can be taken all the year round, and is best in autumn and winter. The medicine is taken twice a day, one spoon (about 30 g) is taken each time, and the medicine is taken with warm boiled water or directly taken by mouth. The ointment is used for the first time, half of the ointment is used for the first time, and the ointment is taken within 15 minutes after meals. After one week, the dosage is adjusted to the usual dosage. For patients with good spleen and stomach function, it can be taken before meal; for those with poor spleen and stomach function, it is taken within 15 minutes after meal. In the process of taking, the paste is not suitable for eating greasy and spicy products, the seafood is rarely used, and strong tea, coffee and the like are not drunk, so that the absorption of the paste formula is not influenced. Radish is not suitable for taking while taking the paste formula. If it is taken after mixing with water, it will precipitate slightly (as powder), and is administered after stirring. Typical cases are: after a certain Wang, a woman in 48 years old and Mashan county suffer from repeated nasal obstruction, headache and memory decline for 5 years, the symptoms are improved after the Chinese medicinal composition is used for 4 courses of treatment according to the administration method. Tan Yi (male, 27 years old, river pool city people), repeated nasal obstruction, snoring and running nose for half a year, and the symptoms are improved after the Chinese medicinal composition is used for 1 course of treatment according to the administration method. In a certain range, women of 36 years old, Guilin people, nasal obstruction, watery nasal discharge, dizziness and sleepiness for 3 years, and the symptoms disappear after the Chinese medicinal composition is used for 4 weeks according to the administration method.

Finally, it should be emphasized that the above-described embodiments are merely preferred examples of the invention, which is not intended to limit the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The traditional Chinese medicine composition for treating nasal sinusitis is characterized by comprising the following raw materials in parts by weight: 20-40 parts of ephedra, 20-35 parts of peony, 9-15 parts of asarum, 20-50 parts of dried ginger, 25-35 parts of liquorice, 25-40 parts of cassia twig, 15-20 parts of schisandra chinensis, 30-35 parts of pinellia ternate, 18-25 parts of grifola, 18-35 parts of poria cocos, 15-20 parts of bighead atractylodes rhizome, 25-30 parts of rhizoma alismatis, 20-35 parts of biond magnolia flower and 20-40 parts of cocklebur fruit.

2. The traditional Chinese medicine composition for treating nose and nasosinusitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 30 parts of ephedra, 30 parts of Chinese herbaceous peony, 12 parts of asarum, 50 parts of dried ginger, 20 parts of liquorice, 30 parts of cassia twig, 12 parts of Chinese magnoliavine fruit, 30 parts of pinellia ternate, 18 parts of polyporus umbellatus, 18 parts of poria cocos, 18 parts of bighead atractylodes rhizome, 30 parts of rhizoma alismatis, 20 parts of biond magnolia flower and 20 parts of cocklebur fruit.

3. The preparation method of the traditional Chinese medicine decoction for treating the nose and the nasosinusitis is characterized by comprising the following steps:

step A: first decocting, namely adding 150-180 g of the raw materials into 1000-4500 mL of water according to the total amount of 150-180 g of the traditional Chinese medicine composition for first decocting, firstly decocting with slow fire until decoction is boiled, then decocting with strong fire for 10-15 min, and pouring out the decoction obtained by the first decocting;

4. A Chinese medicinal decoction for treating nasal sinusitis, which is prepared by the preparation method according to claim 3.

5. The preparation method of the oral paste for treating the nose and the nasosinusitis is characterized by comprising the following steps:

step a: medicine soaking: the traditional Chinese medicine composition for treating nasal sinusitis according to claim 1 or 2, wherein the raw materials are put into a container after being metered according to the total amount of 150-180 g, and then are added with water for soaking, wherein the water surface is 15-18 cm higher than the medicine surface, and the soaking time is about 18-20 hours;

6. The method according to claim 5, wherein in step b, the cocklebur fruit is fried.

7. The method according to claim 5, wherein in the step d, the auxiliary material includes at least one of a sugar, a gum, and an alcoholic beverage; the saccharide is at least one of flos Osmanthi Fragrantis Mel and xylitol, the gum is at least one of colla Corii Asini, colla Plastri Testudinis and colla Cornus Cervi, and the wine is yellow wine.

8. An oral paste for the treatment of nasal and nasal sinusitis, characterized by being prepared by the preparation method according to any one of claims 5 to 7.