Summary of the invention
Technical assignment of the present invention is at above the deficiencies in the prior art, and the medicated tea of a kind of preparation method for the preparation of prevention upper respiratory tract infection is provided.
The technical scheme that the present invention solves its technical problem is: a kind of preparation method of preventing the upper respiratory tract infection medicated tea, described medicated tea crude drug is made up of Herba Caryopteridis Incanae, Herba Lysimachiae foenum-graeci, Flos Lonicerae, Folium Mori, Semen Armeniacae Amarum, Herba Dendrobii, Myriogyne minuta, Folium eucalypti globueli (Eucalyptus globulus Labill.), big Herba Swertiae heteranthae, tea, it is characterized in that, formed by following steps:
(1) Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Caryopteridis Incanae, Myriogyne minuta, Herba Dendrobii, Flos Lonicerae, Herba Lysimachiae foenum-graeci are ground into powder, cross 20 mesh sieves, mix, with supercritical carbon dioxide cyclic countercurrent extraction 1 ~ 6 hour, extracting pressure 5 ~ 40Mpa, 30 ~ 70 ℃ of extraction temperature get mixed volatilization oil;
(2) with Semen Armeniacae Amarum, Folium Mori, big Herba Swertiae heteranthae, tea, decocting in water extracts 2 times, and each 0.5 ~ 1 hour, merge extractive liquid, filtered, and is concentrated into relative density 1.05 ~ 1.2, stirs when being cooled to 40 ~ 50 ℃ to add step 1 gained mixed volatilization oil down, and mixing gets material just;
(3) step 2 gained is just expected drying and crushing, get granule.
Drying and crushing described in the above-mentioned steps 3 can be the cryogenic vacuum spray drying.
Drying and crushing described in the above-mentioned steps 3 also can be lyophilization, comminuting method.
Wherein said: Herba Caryopteridis Incanae is Verenaceae Herba Caryopteridis Incanae platymiscium Herba Caryopteridis Incanae herb or root.The nature and flavor suffering, temperature.But the merit dispelling wind to relieve the exterior syndrome, expelling phlegm for arresting cough, the silt pain relieving of loosing.
Herba Lysimachiae foenum-graeci, Primulaceae Lysimachia plant Herba Lysimachiae foenum-graeci herb.Nature and flavor are sweet, light, and are flat.But the merit heat clearing away, circulation of qi promoting, ascarid is driven in pain relieving.
Flos Lonicerae is the flower that Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or band are just opened, but the merit heat-clearing and toxic substances removing reaches eliminating evilly thoroughly, and dispelling wind-heat is kind removing summer-heat blood poison also.
Folium Mori are the dried leaves of moraceae plants Mulberry, but the merit dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, cooling blood for hemostasis.
Semen Armeniacae Amarum is the seed of rosaceous plant Fructus Pruni, wild apricot, Prunus armeniaca L.var.ansu Maxim., prunus mandshuricaKoehne, but the merit lung qi dispersing, loosening bowel to relieve constipation.
Herba Dendrobii is the fresh or dry stem of orchid dendrobium loddigesii Rolfe, Herba Dendrobii oculati, HERBA DENDROBII, Herba Dendrobii or Dendrobium nobile.Nature and flavor are sweet, are slightly cold.Return stomach, kidney channel.But the merit reinforcing stomach reg fluid, nourishing YIN and clearing away heat.
Myriogyne minuta is the dry herb of the annual herbelet of Myriogyne minuta.Nature and flavor are sweet, light, and are flat.Merit can sharp nine orifices, stuffy nose relieving gas.
Folium eucalypti globueli (Eucalyptus globulus Labill.) is the leaf of myrtle Eucalyptus globulus Labill.Toil, cold.But merit dispelling wind to relieve the exterior syndrome; Heat-clearing and toxic substances removing; Phlegm-eliminiating and qi-regulating; Killing parasites for relieving itching.
Big Herba Swertiae heteranthae is aristolochiaceae plant the become mildewed herb of Herba Asari or root, rhizome.The nature and flavor suffering; Temperature.But merit warming the lung to eliminate phlegm; Expelling wind and removing dampness; Regulating QI to relieve pain.
Tea is the bud-leaf of plant of theaceae tea.Cold nature, bitter but sweet flavor, GUIXIN, lung, stomach warp.The refresh oneself, relieving thirst and restlessness is reduced phlegm, and helps digestion diuresis, detoxifcation.In the kind of various tea, wherein the heat clearing away effect of green tea is better.
Composition principle: the upper respiratory tract infection traditional Chinese medical science is referred to as " flu ", for exopathogen is invaded due to lung defends." element asks YIN YANG classification of natural phenomena big opinion " said: " lung controlling nose ... be nose at key ", nose is key outside the lung, the door of gas discrepancy, and department's olfactory sensation helps pronunciation, under lung system.Exopathogen is violated lung, and the nose key stands in the breach, so flu is seen nasal obstruction, watery nasal discharge sneeze more.Theory of Chinese medical science thinks, no matter the outer excessive heat of upper respiratory tract infection, or interior fire of making mostly is lung meridian and intimately meets with the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure and cause that prevention should be started with from expelling wind and clearing away heat.Select Herba Caryopteridis Incanae, big Herba Swertiae heteranthae expelling wind and cold pathogens in the prepared tea side of the present invention for use; Flos Lonicerae, Folium Mori, Folium eucalypti globueli (Eucalyptus globulus Labill.) dispelling wind-heat; Herba Lysimachiae foenum-graeci, Flos Lonicerae, Folium eucalypti globueli (Eucalyptus globulus Labill.), tea are at interior heat-clearing and toxic substances removing; And the Semen Armeniacae Amarum lung qi dispersing is arranged, the Herba Dendrobii nourishing YIN and clearing away heat.In addition, Herba Centipedae record in " book on Chinese herbal medicine converge speech ": " Herba Centipedae, sharp nine orifices; the medicine of stuffy nose relieving gas also, its acrid in the mouth is strong, its gas is hot smoked; its property liter looses, and can lead to lung meridian, on reach brains; the main phlegm dyspnea of event, gas-tight obstructed, the nasal polyp of having a stuffy nose; feeling of distension and oppression is unfavorable; go cataracta in the order, and in cold-evil, wind syndrome of head headache disease, all get the diffusing merit of hot temperature rise also." and Myriogyne minuta can also draw all medicines and go into lung meridian.Modern pharmacological research shows: the plain sodium of the main component Herba Caryopteridis Incanae of Herba Caryopteridis Incanae (blue plain sodium) has the obvious suppression effect at external (tube dilution method) to staphylococcus aureus and diphtheria corynebacterium, to typhoid fever, first type and paratyphoid B, green pus, large intestine, dysentery bacillus such as (Fu Shi) and Hemolytic streptococcus also have certain effect; Higher concentration is sterilization, and low concentration is antibacterial; The in vivo test proof has good effect to the mice infection of staphylococcus aureus, can make most of animals avoid death.Flos Lonicerae has antiinflammatory, anti-allergy action, and than the antibacterial action of wide range.Herba Lysimachiae foenum-graeci volatile oil has the effect of inhibition and inactivating influenza virus in Embryo Gallus domesticus.The eucalyptus oil that Folium eucalypti globueli (Eucalyptus globulus Labill.) proposes has inhibitory action to gram-positive bacterium, clostridium tetani and diphtheria corynebacterium toxin is had detoxicating adhesive in vitro, the internal energy anti-mycobacterium tuberculosis of test tube (H37Rv).Big Herba Swertiae heteranthae aqueous extract can suppress oxygen consumption and the succinic dehydrogenase activity thereof of staphylococcus aureus and Salmonella paratyphi, and this inhibitory action and Gram-reaction are irrelevant.
In sum, this product compound basis Chinese herb decoction opinion is administered opinion and is got in conjunction with the modern medicine and pharmacology result of study cooperates, and plays the effect of expelling wind and clearing away heat altogether, thereby can effectively reach the effect of prevention upper respiratory tract infection.
Compared with prior art, the present invention has following characteristics.
1. finished product of the present invention is the granule dosage form, takes after mixing it with water conveniently.
2. distinguish effective component extracting, the product better effects if, the effective dose volume is littler, and conservation, and cost is low.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, the crude drug weight proportion: 14 parts of Herba Caryopteridis Incanaes, 10 parts of Herba Lysimachiae foenum-graeci, 10 parts of Flos Loniceraes, 10 parts on Folium Mori, 6 parts in Semen Armeniacae Amarum, 14 parts of Herba Dendrobiis, 14 parts of Myriogyne minutas, 1 part of Folium eucalypti globueli (Eucalyptus globulus Labill.), 3 parts of big Herba Swertiae heteranthaes, 50 parts of black tea.
Preparation method is as follows:
(1) Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Caryopteridis Incanae, Myriogyne minuta, Herba Dendrobii, Flos Lonicerae, Herba Lysimachiae foenum-graeci are ground into powder, cross 20 mesh sieves, mix, with supercritical carbon dioxide cyclic countercurrent extraction 6 hours, extracting pressure 40Mpa, 70 ℃ of extraction temperature get mixed volatilization oil;
(2) with Semen Armeniacae Amarum, Folium Mori, big Herba Swertiae heteranthae, tea, decocting in water extracts 2 times, and each 1 hour, merge extractive liquid, filtered, and is concentrated into relative density 1.2, stirs when being cooled to 50 ℃ to add step 1 gained mixed volatilization oil down, is mixed into material just;
(3) step 2 gained is just expected the pulverizing of cryogenic vacuum spray drying, get granule.
Embodiment 2, the crude drug weight proportion: 14 parts of Herba Caryopteridis Incanaes, 10 parts of Herba Lysimachiae foenum-graeci, 10 parts of Flos Loniceraes, 10 parts on Folium Mori, 6 parts in Semen Armeniacae Amarum, 14 parts of Herba Dendrobiis, 14 parts of Myriogyne minutas, 1 part of Folium eucalypti globueli (Eucalyptus globulus Labill.), 3 parts of big Herba Swertiae heteranthaes, 50 parts of green tea.
Preparation method is as follows:
(1) Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Caryopteridis Incanae, Myriogyne minuta, Herba Dendrobii, Flos Lonicerae, Herba Lysimachiae foenum-graeci are ground into powder, cross 20 mesh sieves, mix, with supercritical carbon dioxide cyclic countercurrent extraction 5 hours, extracting pressure 30Mpa, 60 ℃ of extraction temperature get mixed volatilization oil;
(2) with Semen Armeniacae Amarum, Folium Mori, big Herba Swertiae heteranthae, green tea, decocting in water extracts 2 times, and each 1 hour, merge extractive liquid, filtered, and is concentrated into relative density 1.1, stirs when being cooled to 45 ℃ to add step 1 gained mixed volatilization oil down, is mixed into material just;
(3) step 2 gained is just expected lyophilization, pulverizing, get granule.
Embodiment 3, the crude drug weight proportion: 20 parts of Herba Caryopteridis Incanaes, 16 parts of Herba Lysimachiae foenum-graeci, 16 parts of Flos Loniceraes, 16 parts on Folium Mori, 10 parts in Semen Armeniacae Amarum, 20 parts of Herba Dendrobiis, 20 parts of Myriogyne minutas, 2 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 5 parts of big Herba Swertiae heteranthaes, 200 parts of Ramulus et Folium Mussaendae Pubescentis.
Preparation method is as follows:
(1) Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Caryopteridis Incanae, Myriogyne minuta, Herba Dendrobii, Flos Lonicerae, Herba Lysimachiae foenum-graeci are ground into powder, cross 20 mesh sieves, mix, with supercritical carbon dioxide cyclic countercurrent extraction 1 hour, extracting pressure 5Mpa, 30 ℃ of extraction temperature get mixed volatilization oil;
(2) with Semen Armeniacae Amarum, Folium Mori, big Herba Swertiae heteranthae, tea, decocting in water extracts 2 times, and each 0.5 hour, merge extractive liquid, filtered, and is concentrated into relative density 1.05, stirs when being cooled to 40 ℃ to add step 1 gained mixed volatilization oil down, is mixed into material just;
(3) step 2 gained is just expected the pulverizing of cryogenic vacuum spray drying, get granule.
Embodiment 4, the crude drug weight proportion: the crude drug weight proportion: 20 parts of Herba Caryopteridis Incanaes, 16 parts of Herba Lysimachiae foenum-graeci, 16 parts of Flos Loniceraes, 16 parts on Folium Mori, 10 parts in Semen Armeniacae Amarum, 20 parts of Herba Dendrobiis, 20 parts of Myriogyne minutas, 2 parts of Folium eucalypti globueli (Eucalyptus globulus Labill.)s, 5 parts of big Herba Swertiae heteranthaes, 200 parts of green tea.
Preparation method is as follows:
(1) Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Caryopteridis Incanae, Myriogyne minuta, Herba Dendrobii, Flos Lonicerae, Herba Lysimachiae foenum-graeci are ground into powder, cross 20 mesh sieves, mix, with supercritical carbon dioxide cyclic countercurrent extraction 1 hour, extracting pressure 5Mpa, 30 ℃ of extraction temperature get mixed volatilization oil;
(2) with Semen Armeniacae Amarum, Folium Mori, big Herba Swertiae heteranthae, tea, decocting in water extracts 2 times, and each 0.5 hour, merge extractive liquid, filtered, and is concentrated into relative density 1.05, stirs when being cooled to 40 ℃ to add step 1 gained mixed volatilization oil down, is mixed into material just;
(3) step 2 gained is just expected lyophilization, pulverizing, get granule.
Embodiment 5, the crude drug weight proportion: 16 parts of Herba Caryopteridis Incanaes, 12 parts of Herba Lysimachiae foenum-graeci, 12 parts of Flos Loniceraes, 12 parts on Folium Mori, 8 parts in Semen Armeniacae Amarum, 16 parts of Herba Dendrobiis, 16 parts of Myriogyne minutas, 1 part of Folium eucalypti globueli (Eucalyptus globulus Labill.), 4 parts of big Herba Swertiae heteranthaes, 100 parts of green tea.
Preparation method is as follows:
(1) Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Caryopteridis Incanae, Myriogyne minuta, Herba Dendrobii, Flos Lonicerae, Herba Lysimachiae foenum-graeci are ground into powder, cross 20 mesh sieves, mix, with supercritical carbon dioxide cyclic countercurrent extraction 3 hours, extracting pressure 20Mpa, 50 ℃ of extraction temperature get mixed volatilization oil;
(2) with Semen Armeniacae Amarum, Folium Mori, big Herba Swertiae heteranthae, tea, decocting in water extracts 2 times, and each 1 hour, merge extractive liquid, filtered, and is concentrated into relative density 1.1, stirs when being cooled to 45 ℃ to add step 1 gained mixed volatilization oil down, is mixed into material just;
(3) step 2 gained is just expected the pulverizing of cryogenic vacuum spray drying, get granule.
Embodiment 6, the crude drug weight proportion: 16 parts of Herba Caryopteridis Incanaes, 12 parts of Herba Lysimachiae foenum-graeci, 12 parts of Flos Loniceraes, 12 parts on Folium Mori, 8 parts in Semen Armeniacae Amarum, 16 parts of Herba Dendrobiis, 16 parts of Myriogyne minutas, 1 part of Folium eucalypti globueli (Eucalyptus globulus Labill.), 4 parts of big Herba Swertiae heteranthaes, 100 parts of oolong teas.
Preparation method is as follows:
(1) Folium eucalypti globueli (Eucalyptus globulus Labill.), Herba Caryopteridis Incanae, Myriogyne minuta, Herba Dendrobii, Flos Lonicerae, Herba Lysimachiae foenum-graeci are ground into powder, cross 20 mesh sieves, mix, with supercritical carbon dioxide cyclic countercurrent extraction 3 hours, extracting pressure 20Mpa, 50 ℃ of extraction temperature get mixed volatilization oil;
(2) with Semen Armeniacae Amarum, Folium Mori, big Herba Swertiae heteranthae, tea, decocting in water extracts 2 times, and each 1 hour, merge extractive liquid, filtered, and is concentrated into relative density 1.1, stirs when being cooled to 45 ℃ to add step 1 gained mixed volatilization oil down, is mixed into material just;
(3) step 2 gained is just expected lyophilization, pulverizing, get granule.
Effective combination of above-mentioned medicated tea is coordinated mutually, effectively reach the purpose of prevention upper respiratory tract infection, and side effect is less.The above results is that clinical data proves that fully interrelated data is as follows, wherein studies medicated tea and uses and be the crude drug weight proportion among the embodiment 5.
1 object and method.
1.1 the healthy artificial samples of object picked at random 40 example, male's 22 examples wherein, women's 18 examples, age span 15 ~ 87 years old, 45.11 ± 19.24 years old mean age.
1.2 method.
1.2.1 research method: 40 routine samples are divided into observation group and blank group at random, and every group of 20 examples, the two age, sex ratio have comparability (P〉0.05).Wherein, medicated tea of the present invention is taken by observation group, every day 6g, morning, decoction being taken at a draught was taken 3 months continuously.
1.2.2 evaluation index: observe and record observation group and blank group 3 months in the ill situation of upper respiratory tract infection.
1.2.3 safety evaluatio: all carry out monitorings such as blood, urine, stool routine, liver, renal function, electrocardiogram before and after observation group is observed.
1.2.4 statistical analysis: carry out statistical analysis with SPSS 13.0, P<0.05 expression has the significance meaning.
2 results.
2.1 the ill situation of upper respiratory tract infection: in 3 months, the blank group has ill case 13 examples, 19 times; Observation group has ill case 4 examples, 4 times.Two groups relatively, and its difference has tangible statistical significance (P<0.01).
2.2 untoward reaction: the vital sign of observation group's sample (blood pressure, heart rate, body temperature, breathing), physical examination, blood biochemical analysis, electrocardiogram and routine urinalysis Non Apparent Abnormality during treating.
3. conclusion: the prompting of this result of study, the present invention prevents upper respiratory tract infection to have good effect and the higher characteristics of safety, is worth clinical practice, popularization.