CN100409882C - Heat clearing and detoxicating drug for abating fever - Google Patents
Heat clearing and detoxicating drug for abating fever Download PDFInfo
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- CN100409882C CN100409882C CNB2005100982970A CN200510098297A CN100409882C CN 100409882 C CN100409882 C CN 100409882C CN B2005100982970 A CNB2005100982970 A CN B2005100982970A CN 200510098297 A CN200510098297 A CN 200510098297A CN 100409882 C CN100409882 C CN 100409882C
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Abstract
The invention discloses a medicinal composition for treating fever, which is prepared from raw materials including honeysuckle flower, capsule of weeping forsythia, plaster stone, clerodendroa cyrtophyllum, wild chrysanthemum flower, mentha, mulberry leaf, corktree bark, root bark of chinese wolf berry, reed rhizome, bitter apricot seed, baikal skullcap root, talcum, anemarrhena rhizome, pericarpium trichosanthis, stem pith of the ricepapr plant and cicada skin.
Description
Technical field
The present invention relates to a kind of fever-lowering medicament for clearing heat and detoxication, in particular to a kind of be the Chinese patent medicine of feedstock production with the Chinese herbal medicine.
Background technology
Flu is a common clinical, frequently-occurring disease.Influenza has also the time popular on a small scale.With regard to its clinical manifestation, most scholars think the flu of the traditional Chinese medical science, viral upper respiratory tract infection and the influenza that influenza seemingly belongs to doctor trained in Western medicine.Above-mentioned disease directly has influence on people's life, working and learning.At present for the fever that causes by a variety of causes, the various mould quasi drugss of the general employing of doctor trained in Western medicine, the treatment fever there is certain curative effect, hyperpyrexia adopts physics to force cooling, but to vehement because of interior-heat diseases caused by exogenous pathogenic factor, interior diplomacy, then treatment just acquires a certain degree of difficulty, and has an injection and brings mentally and physically misery for the patient, and the product toxic and side effects is bigger approximately for mould class, brings drug-induced disease easily.Physical temperature-lowering is controlled in table do not control.Though traditional Chinese medical science preparation is more, as Radix Bupleuri liver soothing soup, Green Dragon soup etc., the treatment fever there is curative effect preferably, need carry out dialectical opinion to control, debate the disease opinion and control, be difficult to gain the essentials.
Summary of the invention
Technical problem to be solved by this invention is to avoid above-mentioned deficiency of the prior art, and propose a kind of efficient, wide spectrum, safely, the fever-lowering medicament for clearing heat and detoxication that has no side effect.
Technical scheme provided by the present invention is: unit of weight is by gram, and it is the medicament of being made by following materials of weight proportions medicine: Flos Lonicerae 5-35, Fructus Forsythiae 5-35, Gypsum Fibrosum 5-35, Folium Isatidis 5-35, Flos Chrysanthemi 3-25, Herba Menthae 5-35, Folium Mori 3-25, Cortex Phellodendri 3-25, Cortex Lycii 5-35, Rhizoma Phragmitis 10-55, Semen Armeniacae Amarum 5-35, Radix Scutellariae 5-35, Talcum 5-35, Rhizoma Anemarrhenae 3-25, Fructus Trichosanthis 5-35, Medulla Tetrapanacis 1-15, Periostracum Cicadae 3-20.
Above-mentioned fever-lowering medicament for clearing heat and detoxication, unit of weight are by gram, and wherein the preferred weight proportioning of each raw material is: Flos Lonicerae 5-30, Fructus Forsythiae 5-30, Gypsum Fibrosum 5-30, Folium Isatidis 5-30, Flos Chrysanthemi 3-20, Herba Menthae 5-30, Folium Mori 3-20, Cortex Phellodendri 3-20, Cortex Lycii 5-30, Rhizoma Phragmitis 10-50, Semen Armeniacae Amarum 5-30, Radix Scutellariae 5-30, Talcum 5-30, Rhizoma Anemarrhenae 3-20, Fructus Trichosanthis 5-30, Medulla Tetrapanacis 1-10, Periostracum Cicadae 3-15.
Above-mentioned fever-lowering medicament for clearing heat and detoxication, unit of weight are by gram, and wherein the optimum weight proportioning of each raw material is: Flos Lonicerae 5-28, Fructus Forsythiae 5-28, Gypsum Fibrosum 5-28, Folium Isatidis 5-28, Flos Chrysanthemi 3-19, Herba Menthae 5-28, Folium Mori 3-19, Cortex Phellodendri 3-19, Cortex Lycii 5-28, Rhizoma Phragmitis 10-45, Semen Armeniacae Amarum 5-28, Radix Scutellariae 5-28, Talcum 5-28, Rhizoma Anemarrhenae 3-19, Fructus Trichosanthis 5-28, Medulla Tetrapanacis 1-9, Periostracum Cicadae 3-14.
Above-mentioned fever-lowering medicament for clearing heat and detoxication, wherein, described medicament is solid preparation such as granule, effervescent tablet, capsule, oral liquid and injection.
The invention provides the preparation method of this fever-lowering medicament for clearing heat and detoxication granule: above ten seven flavor medicines, get Radix Scutellariae and in boiling water, decoct three times, each 0.5 hour, merge extractive liquid, filtered, and the filtrate adjust pH is extremely acid, and is incubated 15 minutes, filters, and filter residue and drying is standby; Fructus Forsythiae, Herba Menthae are extracted volatile oil with vapor distillation, and volatile oil is made the betacyclodextrin clathrate, and the water liquid after the distillation filters, and filtrate is concentrated into clear paste; Filtering residue and all the other Flos Loniceraes etc. 14 flavor medicines decoct with water twice, and each 1 hour, filter, filtrate is concentrated into clear paste, adds ethanol after cooling and makes and contain the alcohol amount and reach 60%, and cold preservation 24 hours filters; Decompression recycling ethanol also is concentrated into clear paste.
Above-mentioned clear paste is merged, and drying under reduced pressure (below 80 ℃) becomes dry extract, pulverizes, and sieves, and adds Radix Scutellariae dry extract, volatile oil betacyclodextrin clathrate and an amount of dextrin, mixing, and medicinal granule of the present invention is promptly made in packing.
Fever-lowering medicament for clearing heat and detoxication of the present invention shows that through pharmacological evaluation following advantage is arranged:
1, the antivirus action in vitro tests shows: medicine of the present invention all has inhibitory action in various degree to respiratory syncytial virus (RSV), parainfluenza virus I type (HVJ), herpesvirus I type, adenovirus 3,7 types.In vivo test shows, medicine of the present invention institute amount of reagent all has the obvious suppression effect to the pneumonia that the influenza virus infecting mouse causes, the lung exponential quantity obviously reduces, weight increase, and pathological examination results shows that pulmonary lesion obviously improves; High, middle dosage group has significant protective effect to the death of influenza virus infecting mouse, obviously prolongs the mice time-to-live.
2, bacteriostasis: medicine of the present invention all has in various degree inhibitory action to 6 kinds of antibacterials such as staphylococcus aureus of being tried.
3, refrigeration function medicine of the present invention rat that yeast is caused and the Typhoid Vaccine fervescence that causes rabbit all has the obvious suppression effect.
4, antiinflammatory action medicine of the present invention all can significantly suppress increasing of mouse peritoneal capillary permeability that acetic acid causes; Obviously alleviate Oleum Tiglii induced mice ear swelling, suppress chondrus ocellatus Holmes colloidality rat paw edema.
5, analgesic activity medicine of the present invention pain that chemistry and thermostimulation are brought out all has the obvious suppression effect.
6, to the immune phagocytic function that medicine of the present invention can improve the mice reticuloendothelial system, raising T lymphocyte rate of dyeing and the mouse antibodies haemolysis value of influencing.
7, acute toxicity test hereditary-less toxicity does not have " three cause " (carcinogenic, mutagenesis, teratogenesis shape) effect yet.Do not see toxic reaction.Give the mice medication to be equivalent to 263.5 times of clinical consumption, and observed continuously 7 days.Do not see the overt toxicity reaction.
More than test shows, medicine of the present invention all has the effect of tangible antiviral, antibacterial, analgesic, antiinflammatory, analgesia, raising immunity.
Clinical drug trial of the present invention is as follows:
1, includes the case standard in
(1) meets the Western medicine diagnose standard.
(2) meet the tcm syndrome diagnostic criteria.
(3) fell ill back 48 hours in.
(4) 3～65 years old age
2, diagnostic criteria
(1) Western medicine diagnose standard: (Chen Haozhu chief editor: practical internal medicine. the 10th edition, the People's Health Publisher)
(1) the popular contact history of flu is arranged.
(2) based on local symptom, General Symptoms can have or be not obvious.
1. local symptom: sneeze, nasal obstruction, watery nasal discharge,, cough sometimes, pharyngalgia, hoarseness, shed tears.
2. General Symptoms: fever with aversion to cold, general malaise, headache and dizziness, extremity aching pain in waist and back.
(3) hemogram: how normal numeration of leukocyte is or on the low side.
(2) tcm syndrome diagnostic criteria:
The interior-heat diseases caused by exogenous pathogenic factor: disease is seen that heating slight chill, headache, malasia, sweating are not smooth, thirsty, is had a stuffy nose, swallows red pain, cough, tongue fur BOHUANG, tongue tip side of red or yellow fur red tongue, floating and rapid pulse or loud.
(3) symptom scalar quantization standard: edit: " new Chinese medicine clinical research guideline " (trying), Beijing: Chinese Medicine science and technology publishing house,, 58 pages in 2002 with reference to the Zheng Xiao cornel.
3, Therapeutic Method: oral medicinal granule of the present invention every day three times, a 1-2 bag, every bag 6 gram was taken 2-3 days.
4, efficacy assessment standard:
Clinical recovery: treat in three days, bring down a fever fully, body temperature reaches normally, the clinical symptoms complete obiteration.
Produce effects: treat in three days, bring down a fever fully, body temperature reaches normally, and clinical symptoms is most of to disappear.
Effectively: treat in three days, bring down a fever not exclusively, body temperature descends, but than normal body temperature height, clinical symptoms partly disappears.
Invalid: clinical symptoms does not have improvement.
5, therapeutic outcome:
Treat 32 routine influenza patients with medicinal granule of the present invention, the result: 16 examples of fully recovering (50.00%), produce effects 8 examples (25.00%), effective 6 examples (18.75%), invalid 2 examples (6.25%); Total more rate 75% that shows; Total effective rate 93.25%.Onset time of wherein on average bringing down a fever is 8.56 hours; It is 26.14 hours that mean body temperature is reduced to normal time.Do not see obvious adverse effect and toxic and side effects in the therapeutic process, illustrate that this medicine takes safer.
Flu is a common clinical, frequently-occurring disease.The cause of disease of medicine indication of the present invention, pathogenesis are felt the heresy of wind heat again for have interior-heat, defend the symptom of showing the discord Lung Qi obstraction so disease just is visible wind heat, as: heating slight chill, headache, malasia, nasal obstruction, the red pain of pharynx, cough etc.; The symptom of visible again qifen fever: as heating, sweating, thirstyly very wait.Control suitable heat-clearing and toxic substances removing, the clearly then all diseases of heat are from disappearing.
Heat-clearing and toxic substances removing febrifuge of the present invention is to analyze the prescription composition, in conjunction with the flavour of a drug of each flavour of a drug in therapeutic process, effect, pharmacological action and effective site, the Chinese patent medicine preparation of on the basis of craft screening and clinical principium application, establishing, this product has fully kept the effective ingredient of medicine, dwindled taking dose, function cures mainly: be used for the heating slight chill that the interior-heat diseases caused by exogenous pathogenic factor cause, headache, malasia, sweating, thirsty, nasal obstruction, swallow red pain, cough, the yellow fur red tongue, floating and rapid pulse or loud, heat clearing away, detoxifcation, bring down a fever, cure mainly upper respiratory tract infection, viral influenza, influenza etc., have efficient, broad spectrum activity, safety, have no side effect, and taking convenience, better stability of preparation helps producing, store and carry.
The specific embodiment
Embodiment 1
Press following proportioning weighting raw materials (gram):
Flos Lonicerae 35, Fructus Forsythiae 34, Gypsum Fibrosum 35, Folium Isatidis 35, Flos Chrysanthemi 18, Herba Menthae 10, Folium Mori 18, Cortex Phellodendri 25, Cortex Lycii 10, Rhizoma Phragmitis 45, Semen Armeniacae Amarum 5, Radix Scutellariae 8, Talcum 25, the Rhizoma Anemarrhenae 5, Fructus Trichosanthis 20, Medulla Tetrapanacis 2, Periostracum Cicadae 4.
Medicine production method of the present invention is as follows:
Get Radix Scutellariae and decoct in boiling water three times, each 0.5 hour, merge extractive liquid, filtered, and the filtrate adjust pH is extremely acid, and is incubated 15 minutes, filters, and filter residue and drying is standby; Fructus Forsythiae, Herba Menthae are extracted volatile oil with vapor distillation, and volatile oil is made the betacyclodextrin clathrate, and the water liquid after the distillation filters, and filtrate is concentrated into clear paste; Filtering residue and all the other Flos Loniceraes etc. 14 flavor medicines decoct with water twice, and each 1 hour, filter, filtrate is concentrated into clear paste, adds ethanol after cooling and makes and contain the alcohol amount and reach 60%, and cold preservation 24 hours filters; Decompression recycling ethanol also is concentrated into clear paste.
Above-mentioned clear paste is merged, and drying under reduced pressure (below 80 ℃) becomes dry extract, pulverizes, and sieves, and adds Radix Scutellariae dry extract, volatile oil betacyclodextrin clathrate and an amount of dextrin, mixing, and packing, every bag 6 gram is promptly made medicinal granule of the present invention.
Embodiment 2
Press following proportioning weighting raw materials (gram):
Flos Lonicerae 30, Fructus Forsythiae 28, Gypsum Fibrosum 30, Folium Isatidis 32, Flos Chrysanthemi 15, Herba Menthae 15, Folium Mori 12, Cortex Phellodendri 20, Cortex Lycii 18, Rhizoma Phragmitis 50, Semen Armeniacae Amarum 10, Radix Scutellariae 15, Talcum 30, the Rhizoma Anemarrhenae 8, Fructus Trichosanthis 25, Medulla Tetrapanacis 1, Periostracum Cicadae 10.
Medicine production method of the present invention is with the production method among the embodiment 1.
Embodiment 3
Press following proportioning weighting raw materials (gram):
Flos Lonicerae 25, Fructus Forsythiae 26, Gypsum Fibrosum 25, Folium Isatidis 26, Flos Chrysanthemi 25, Herba Menthae 30, Folium Mori 5, Cortex Phellodendri 24, Cortex Lycii 30, Rhizoma Phragmitis 35, Semen Armeniacae Amarum 20, Radix Scutellariae 20, Talcum 10, the Rhizoma Anemarrhenae 15, Fructus Trichosanthis 35, Medulla Tetrapanacis 5, Periostracum Cicadae 3.
Medicine production method of the present invention is with the production method among the embodiment 1.
Embodiment 4
Press following proportioning weighting raw materials (gram):
Flos Lonicerae 15, Fructus Forsythiae 16, Gypsum Fibrosum 20, Folium Isatidis 15, Flos Chrysanthemi 15, Herba Menthae 30, Folium Mori 10, Cortex Phellodendri 15, Cortex Lycii 25, Rhizoma Phragmitis 20, Semen Armeniacae Amarum 25, Radix Scutellariae 26, Talcum 20, the Rhizoma Anemarrhenae 25, Fructus Trichosanthis 5, Medulla Tetrapanacis 9, Periostracum Cicadae 14.
Medicine production method of the present invention is with the production method among the embodiment 1.
Embodiment 5
Press following proportioning weighting raw materials (gram):
Flos Lonicerae 10, Fructus Forsythiae 9, Gypsum Fibrosum 15, Folium Isatidis 8, Flos Chrysanthemi 6, Herba Menthae 20, Folium Mori 25, Cortex Phellodendri 7, Cortex Lycii 20, Rhizoma Phragmitis 55, Semen Armeniacae Amarum 35, Radix Scutellariae 28, Talcum 5, the Rhizoma Anemarrhenae 18, Fructus Trichosanthis 10, Medulla Tetrapanacis 15, Periostracum Cicadae 12.
Medicine production method of the present invention is with the production method among the embodiment 1.
Embodiment 6
Press following proportioning weighting raw materials (gram):
Flos Lonicerae 6, Fructus Forsythiae 6, Gypsum Fibrosum 9, Folium Isatidis 9, Flos Chrysanthemi 5, Herba Menthae 15, Folium Mori 22, Cortex Phellodendri 6, Cortex Lycii 28, Rhizoma Phragmitis 10, Semen Armeniacae Amarum 28, Radix Scutellariae 35, Talcum 15, the Rhizoma Anemarrhenae 19, Fructus Trichosanthis 15, Medulla Tetrapanacis 13, Periostracum Cicadae 15.
Medicine production method of the present invention is with the production method among the embodiment 1.
Claims (4)
1. fever-lowering medicament for clearing heat and detoxication, it is characterized in that: unit of weight is by gram, and it is the medicament of being made by following materials of weight proportions medicine:
Flos Lonicerae 5-35, Fructus Forsythiae 5-35, Gypsum Fibrosum 5-35, Folium Isatidis 5-35, Flos Chrysanthemi 3-25, Herba Menthae 5-35, Folium Mori 3-25, Cortex Phellodendri 3-25, Cortex Lycii 5-35, Rhizoma Phragmitis 10-55, Semen Armeniacae Amarum 5-35, Radix Scutellariae 5-35, Talcum 5-35, Rhizoma Anemarrhenae 3-25, Fructus Trichosanthis 5-35, Medulla Tetrapanacis 1-15, Periostracum Cicadae 3-20.
2. fever-lowering medicament for clearing heat and detoxication according to claim 1, unit of weight are by gram, and wherein the weight proportion of each material medicine is: Flos Lonicerae 5-30, Fructus Forsythiae 5-30, Gypsum Fibrosum 5-30, Folium Isatidis 5-30, Flos Chrysanthemi 3-20, Herba Menthae 5-30, Folium Mori 3-20, Cortex Phellodendri 3-20, Cortex Lycii 5-30, Rhizoma Phragmitis 10-50, Semen Armeniacae Amarum 5-30, Radix Scutellariae 5-30, Talcum 5-30, Rhizoma Anemarrhenae 3-20, Fructus Trichosanthis 5-30, Medulla Tetrapanacis 1-10, Periostracum Cicadae 3-15.
3. fever-lowering medicament for clearing heat and detoxication according to claim 1, unit of weight are by gram, and wherein the weight proportion of each material medicine is: Flos Lonicerae 5-28, Fructus Forsythiae 5-28, Gypsum Fibrosum 5-28, Folium Isatidis 5-28, Flos Chrysanthemi 3-19, Herba Menthae 5-28, Folium Mori 3-19, Cortex Phellodendri 3-19, Cortex Lycii 5-28, Rhizoma Phragmitis 10-45, Semen Armeniacae Amarum 5-28, Radix Scutellariae 5-28, Talcum 5-28, Rhizoma Anemarrhenae 3-19, Fructus Trichosanthis 5-28, Medulla Tetrapanacis 1-9, Periostracum Cicadae 3-14.
4. according to each described fever-lowering medicament for clearing heat and detoxication of claim 1 to 3, it is characterized in that: described medicament is solid preparation, oral liquid or injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100982970A CN100409882C (en) | 2005-09-06 | 2005-09-06 | Heat clearing and detoxicating drug for abating fever |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100982970A CN100409882C (en) | 2005-09-06 | 2005-09-06 | Heat clearing and detoxicating drug for abating fever |
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| CN1927351A CN1927351A (en) | 2007-03-14 |
| CN100409882C true CN100409882C (en) | 2008-08-13 |
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| CNB2005100982970A Expired - Fee Related CN100409882C (en) | 2005-09-06 | 2005-09-06 | Heat clearing and detoxicating drug for abating fever |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199747B (en) * | 2007-12-12 | 2012-03-07 | 陈德顺 | Oral administration Chinese medicine for treating liver stomach heat evil toothache |
| CN101766791B (en) * | 2010-04-19 | 2011-06-15 | 泰一和浦（北京）中医药研究院有限公司 | Chinese herbal composite for fever treatment and preparation method thereof |
| CN103652102A (en) * | 2012-09-03 | 2014-03-26 | 宁国红楼梦旅游产品开发有限公司 | Pathogenic fire-discharging rhizoma phragmitis tea and preparation method thereof |
| CN103877219A (en) * | 2012-12-20 | 2014-06-25 | 赵翠 | Heat-clearing composition for treating cold |
| CN103638313B (en) * | 2013-12-11 | 2015-10-21 | 马家庆 | A kind of Chinese medicine for the treatment of fever due to yang insufficiency |
| CN103656601A (en) * | 2013-12-23 | 2014-03-26 | 青岛安信医疗器械有限公司 | Traditional Chinese medicinal decoction for treating bacterial pneumonia |
| CN103961583A (en) * | 2014-05-23 | 2014-08-06 | 张俊青 | Chinese herbal preparation for treating viral influenza and preparation method thereof |
| CN106581294A (en) * | 2016-11-30 | 2017-04-26 | 四川旭华制药有限公司 | Antipyretic pharmaceutical composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1123170A (en) * | 1994-11-18 | 1996-05-29 | 吕建京 | Children's oral-medicine for clearing away heat and toxic material and preparation technology thereof |
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2005
- 2005-09-06 CN CNB2005100982970A patent/CN100409882C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1123170A (en) * | 1994-11-18 | 1996-05-29 | 吕建京 | Children's oral-medicine for clearing away heat and toxic material and preparation technology thereof |
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| CN1927351A (en) | 2007-03-14 |
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