CN104257956A - Traditional Chinese medicine composition with effects of relieving cough and asthma - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition with effects of relieving cough and asthma and a preparation method of the traditional Chinese medicine composition. The composition is prepared from the following raw materials: houttuynia cordata, astragalus, loquat leaves, almonds, aster, orange peel, radix peucedani, typhonium giganteum and pinellia ternate. After perilla frutescens and radix saposhnikoviae are added, the traditional Chinese medicine composition can be used for severe cold patients. The invention also provides the preparation method of the traditional Chinese medicine composition with the effects of relieving cough and asthma. The composition disclosed by the invention is exact in curative effect, good in safety and free of side effects on the aspect of treating cough, respiratory tract infection and trachitis and is remarkable in curative effect on treating cough, respiratory tract infection, trachitis and the like caused by diabetic complications.

Description

A kind of Chinese medicine composition of relieving cough and asthma

Technical field

The present invention relates to pharmaceutical sanitary field, be specifically related to Chinese medicine composition of a kind of relieving cough and asthma and preparation method thereof.

Background technology

Cough is one of common symptom of lung pattern disease, begins to be loaded in "Nei Jing".The traditional Chinese medical science is thought, cough is the impairment of dispersing and descending function of the lung caused by exopathogen infringement lungs or visceral dysfunction, abnormal rising of lung-QI.From modern medical theory, cough as a kind of important defense mechanism, the pharyngeal and whole viscous secretion of respiratory tract and the harmful substance of suction and foreign body can be removed by cough.From physiology, coughing to the scavenging action of air flue is useful when excess secretion, and frequently violent cough can affect the breathing of patient and the function of heart.Very long history development procedure be experienced by the understanding of " cough ", " ten cough " from " visceral cough " of "Nei Jing" to Sui's Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases ", i.e. wind, cold, , the heart, liver, spleen, kidney, gallbladder, faint and to cough etc. ten kinds: from Au element to cough pathogenesis and Coryza Treated by Syndrome Differentiation, period of Ming and Qing are with Wang Kentang, Zhao Xianke is that the doctor of representative is to the further investigated of cough etiology and pathogenesis, to modern Application high-tech means to cough physiology and pathomechanism profound level dissect, and by means of the new experimental apparatus emerged in an endless stream and experimental technique, then more deep to its research, thoroughly.

Western medical treatment is coughed, generally based on antiinflammatory.As caused cough after flu, except antiviral cures cold, the many and same use of antibiotic, controls upper respiratory tract and bronchitis rapidly; Cough recurrent exerbation also accompanies asthma person, except infection, also uses spasmolytic anti-asthmatic, as peace tea alkali and salbutamol, to remove tracheospasm simultaneously; Because of the cough that rhinitis, sinusitis, tonsillitis etc. cause, mostly with caused by trachea concurrent infection, therefore can for the topical therapeutic of naso-pharynageal disease when treatment, as taken out pus to the puncture of sinusitis, to tonsillitis and the Fructus Persicae Corpectomy etc. of enlargement.About the typing of cough, from doctor trained in Western medicine angle, be divided into larynx source property, drug induccd and allergic cough etc.

The traditional Chinese medical science is thought, the cause of disease of cough, and one is the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, and two is pathogenic QIs in the body of internal organs, all can cause that lung qi is unclear to be lost in a surname respectful, compels gas superinverse and coughs.No matter diseases caused by exogenous pathogenic factor or the cough caused by internal injury, all involves lungs by sick, by lung qi unclear lose respectful in a surname caused by, therefore " Jing Yue's complete work cough " is said: " though cough demonstrate,prove many, pneumonopathy nothing but." " Medicine Comprehended " point out: " lung body belongs to gold, kowtows and does not ring, the heresy of wind and cold heat-damp in summer dryness-fire six climate exopathogens such as Zhong Ran, Zhong Fei, and from then ringing of hitting outward, labor is for feelings will, and fire then also the ringing from inside fire attack of fighting processed by diet." point out cough to be that inside and outside pathogenic factor violates lung, lungs reach produced a kind of pathological reaction outside eliminating evil.Exogenous cough and endogenous cough also can influence each other as disease, and the sick then domination of pathogen of a specified duration transfers to weakened body resistance.Exogenous cough's such as delay mistake is controlled, and evil impairing the lung gas, more easily feels evil repeatedly, and causes cough and do repeatly, transfers endogenous cough to; Lungs are ill, weakened defensive QI, are subject to exopathogen and cause or increase the weight of, particularly evident when climate change especially.Of a specified duration then empty from real-turn, lungs are weak, deficiency of YIN leading to consumption of QI.It can thus be appreciated that though cough has dividing of diseases caused by exogenous pathogenic factor, internal injury, both again can reciprocal causation sometimes.

Exogenous cough, disease name, the cough caused by being invaded by exogenous pathogen.See " Jing Yue's complete work assorted card plan ", " Principle and Prohibition for Medical profession " rolls up five: " wind-fire heat is wet dry cold, and all can take advantage of lung, all foot causes and coughs." to show as onset comparatively anxious, sound is contained and turbid, doublely sees the diseases caused by exogenous pathogenic factor diseases such as cold and heat, headache, general pain, nasal obstruction, watery nasal discharge, dry pharynx, itching of the throat.Mostly empirical, controlling should eliminating pathogen for dispersing lung-QI.Due to exopathogen character and the difference felt of holding concurrently, there is the difference such as the cough due to common cold, typhoid cough, pyretic cough, cough due to summer-heat affection, the cough due to dryness, cough due to damp pathogen, cough due to wind and cold, cryopyrogenous cough, pestilent cough.

Exogenous cough because the climatic factor of causing a disease is different, and shows as multiple pattern of syndrome, and the normal various cold symptoms caused with extreme climate factor: 1. wind-cold affecting lung symptom: itching throat cough is low voice speaking, out of breath, thin color of coughing up phlegm is white, often accompanies nasal obstruction, snivel, headache, the exterior syndromes such as limbs are miserable, fever with aversion to cold, lossless, thin white fur of tongue, floating pulse or floating tight.Method for the treatment of: expelling wind and cold, lung qi dispersing cough-relieving.2. wind-heat invading the lung symptom: cough is frequently acute, rough or to cough sound loud, high-pitched sound mute, the dry pharyngalgia of larynx, coughs up phlegm not well, thick sputum or thick Huang, sweating when coughing, normal companion's nose stream yellow thick nasal discharge, thirsty, headache, limb Chu, aversion to wind, the exterior syndromes such as fever of the body, tongue fur BOHUANG, floating and rapid pulse or slick and frivolous.Method for the treatment of: wind and heat dispersing, lung qi dispersing cough-relieving.3. wind-dryness impairing the lung symptom: itching of the throat dry cough, choke repeatedly, pharyngodynia with dryness, rear xeromycteria, without expectorant or the few and adhesion filamentation of expectorant, not easily bring up, or sputum with blood streaks, xerostomia, from the beginning of or the exterior syndrome such as companion has a stuffy nose, has a headache, is slightly cold, fever of the body, red tongue is done and few Tianjin, white and thin fur or BOHUANG, floating and rapid pulse or decimal.Method for the treatment of: dispelling wind lung heat clearing, moistens dryness and relieve cough.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition of relieving cough and asthma;

Another object of the present invention is to provide a kind of Chinese medicine composition preparation method of relieving cough and asthma.

The object of the invention is by following technical scheme realize:

The Chinese medicine composition of relieving cough and asthma of the present invention is prepared from by the raw material containing following weight portion:

Herba Houttuyniae 5-20 part, Radix Astragali 5-20 part, Folium Eriobotryae 5-20 part, Semen Armeniacae Amarum 5-15 part, Radix Asteris 5-20 part, Pericarpium Citri Reticulatae 5-20 part, Radix Peucedani 5-20 part, seven lotus 5-20 parts, Rhizoma Pinelliae Preparatum 5-20 part, Folium Perillae 5-20 part, Radix Saposhnikoviae 5-20 part.

Preferably, be prepared from by the raw material containing following weight portion:

Herba Houttuyniae 8-15 part, Radix Astragali 8-15 part, Folium Eriobotryae 6-15 part, Semen Armeniacae Amarum 6-12 part, Radix Asteris 6-15 part, Pericarpium Citri Reticulatae 6-15 part, Radix Peucedani 6-15 part, seven lotus 6-15 parts, Rhizoma Pinelliae Preparatum 6-15 part, Folium Perillae 5-20 part, Radix Saposhnikoviae 5-20 part.

More preferably, be prepared from by the raw material containing following weight portion:

Herba Houttuyniae 10 parts, the Radix Astragali 10 parts, Folium Eriobotryae 10 parts, Semen Armeniacae Amarum 10 parts, Radix Asteris 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Peucedani 10 parts, 10 parts, seven lotuses, Rhizoma Pinelliae Preparatum 10 parts, Folium Perillae 5-20 part, Radix Saposhnikoviae 5-20 part.

Below crude drug source of the present invention:

Herba Houttuyniae is fresh herb or the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..Fresh goods all can be tapped the whole year; Tap when the luxuriant spica of dry product stem and leaf in summer is many, removing impurity, dries.Cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.There is heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; The merit of inducing diuresis for treating stranguria syndrome.Cure mainly pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.Modern study shows, Herba Houttuyniae has the effect such as antibacterial, antiviral, antiinflammatory, enhancing human body immunity, relieving cough and asthma, diuresis.In addition, pharmacological evaluation shows, Herba Houttuyniae can improve diabetes rat insulin resistant, obviously can suppress the hypertrophy of diabetic model rats glomerule, reduce 24h and urinate B2 microglobulin, 24h urinary albumin excretion ratio and creatinine clearance rate, the urine protein of diabetes rat can be alleviated, Pathological changes.

The Radix Astragali is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Sweet in the mouth, warm in nature.Return lung, spleen, liver, kidney channel.The Radix Astragali has effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating, raw by consolidating superficial resistance holder skin ulcer.

Folium Eriobotryae is rosaceous plant Folium Eriobotryae Eriobotryajaponica(Thunb.) leaf of Lindl..Hardship, is slightly cold.Return lung, stomach warp.There is clearing away lung-heat to relieve cough, the merit of stopping nausea and vomiting by lowering the adverse flow of QI.Cure mainly cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, hiccup.

Semen Armeniacae Amarum, another name: Semen Armeniacae Amarum.Latin literary fame: Semen Armeniacae Amarum. is rosaceous plant Prunus armeniaca L.var.ansu Maxim., mature fruit of gathering summer, removing sarcocarp and nucleocapsid, take out seed, dry.Bitter, tepor, slightly poisonous.Return liver, large intestine channel.Sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.For cough and asthma, fullness in the chest abundant expectoration, blood deficiency Tianjin is withered, dryness of the intestine constipation.Be good at falling lung qi to relieving asthma, control breathing with cough of excess of the lung.

Radix Asteris, another name: Radix Asteris.For the dry root and rhizome of feverfew Radix Asteris Aster tataricus L. f..Spring, Qiu Erji excavate, and removing has the rhizome of joint (practise and claim " parent root ") and silt, weaves into pigtail and dries, or directly dry.Warm in nature, bitter in the mouth, pungent.Nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.

Pericarpium Citri Reticulatae, another name: Pericarpium Citri tangerinae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Harvesting ripe fruit, strips peel, dries or cold drying.Bitter, pungent, temperature.Return lung, spleen channel.Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Radix Peucedani is the dry root of samphire Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn or RADIX PEUCEDANI Peucedanum decursivum Maxim..Winter withers to time spring stem and leaf or excavates when not taking out scape, and removing fibrous root, cleans, dry or cold drying.Bitter, pungent, be slightly cold.Return lung meridian.Loose wind heat clearing away, lowering the adverse-rising QI to resolve phlegm.For cough due to pathogenic wind-heat's abundant expectoration, expectorant dyspnea of heat type is full, coughs up phlegm yellow thick.

Seven lotuses, another name: south heavy building, Herba Typhonii gigantei (Maguan, Yunnan), plays card solely words (Hani of Lvchun County language).Hardship, is slightly cold; Slightly poisonous.Return Liver Channel.The function of have heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, eliminate the phlegm, relieving asthma, stopping blooding.

For furuncle carbuncle, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, convulsion with spasms.

Rhizoma Pinelliae Preparatum is the Preparation process product of the tuber of the aroid Rhizoma Pinelliae (Pinellia ternata (Thunb) Breit.).Pungent, warm.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm.For dry laryngopharynx, abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache.

Folium Perillae is the dried leaves (or band twig) of labiate Folium Perillae Perilla frutescens (L.) Britt.Gather when summer, branch and leaf were luxuriant, removing impurity, dries.Warm in nature, acrid in the mouth.Return lung, spleen channel.Induce sweat cold expelling, relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.

Radix Saposhnikoviae is the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Spring, Qiu Erji excavate the root not taking out scape plant, and removing fibrous root and silt, dry.Acrid in the mouth, sweet, warm in nature.Return bladder, liver, spleen channel.Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.

Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is the alcohol reflux adopting water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows:

Scheme one: get whole 9 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains active component.

Scheme two: get whole 9 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, add ethanol, make alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.

Scheme three: get whole 9 taste medical materials, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 4-10 of medical material total amount doubly, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.

The Chinese medicine composition of relieving cough and asthma of the present invention, with pharmaceutically acceptable carrier combination, can make various common dosage forms, as tablet, granule, capsule, syrup etc.

Pharmaceutically acceptable carrier of the present invention includes but not limited to following:

Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline Cellulose, inorganic salt, sugar alcohols etc.

Wetting agent and binding agent: purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc.

Disintegrating agent: starch, carboxymethyl starch sodium, cellulose derivative, polyvinylpolypyrrolidone etc.

Lubricant: magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc.

Cosolvent: water, ethanol, glycerol, propylene glycol, liquid Paraffin, plant wet goods.

Correctives: sucrose, monosaccharide, aromatic etc.

Antiseptic: benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc.

Method 1: tablet

Get one of scheme one to scheme three gained active component, add tablet and commonly use adjuvant, production method is prepared into Tablets routinely.

Above-mentioned tablet is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.

Method 2: granule

Get one of scheme one to scheme three gained active component, add granule and commonly use adjuvant, production method is prepared into granule of the present invention routinely.

Above-mentioned granule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent or whole.

Method 3: capsule

Get one of scheme one to scheme three gained active component, add capsule and commonly use adjuvant, production method is prepared into granule of the present invention routinely.

Above-mentioned capsule is commonly used adjuvant and is comprised one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.

Method 4: syrup

Get one of scheme one to scheme three gained active component, add syrup and commonly use adjuvant, production method is prepared into syrup of the present invention routinely.

Above-mentioned syrup is commonly used adjuvant and is comprised one of correctives, antiseptic, cosolvent or whole.

Method 5: mixture

Get one of scheme one to scheme three gained active component, add mixture and commonly use adjuvant, production method is prepared into mixture of the present invention routinely.

Above-mentioned mixture is commonly used adjuvant and is comprised one of correctives, antiseptic or whole.

According to theory of Chinese medical science, cough generally has diseases caused by exogenous pathogenic factor and internal injury two kinds of causes of disease to cause.About Calcium entry, "Nei Jing" has cloud, cough because of in wind, cold, summer-heat, wet, dry, fiery person.Doctor trained in Western medicine indication upper respiratory tract, comprises nasal cavity, pharynx, larynx, and the viral or bacterial infection at these positions, is generically and collectively referred to as upper respiratory tract infection, also known as cold, flu, is all main symptom with cough.Acute bronchitis can be spread by upper respiratory tract infection; The infection that also can be subject to virus or antibacterial because of bronchus causes, and cough is still main symptom.Pneumonia is also a kind of common respiratory tract disease, though have lobar pneumonia, bronchopneumonia, viral pneumonia not, and its pathogenic factor, cardinal symptom, also same as described above.Above three class disease symptomses, except cough, from the beginning of mostly having headache, fever with aversion to cold, aversion to wind, nasal obstruction heavy sensation of the body, sneezes watery nasal discharge more, thirsty or thirsty, has antiperspirant or lossless etc., all identical with the symptom of exogenous cough, therefore belongs to traditional Chinese medical science exogenous cough category.

The applicant is reference modern pharmacological research achievement on the basis of research tradition tcm syndrome differentiation and treatment, and combine through test for many years, multiple formulations is screened, have found lower Chinese medicine composition exogenous cough and upper respiratory tract infection and bronchitis being had to better therapeutic effect that cooperatively interacts, for the inclined severe one of wind and cold, on the basis of drug composition hereinto, increase Folium Perillae, Radix Saposhnikoviae 2 taste medicine.In addition, originally can treat cough that diabetic complication causes, respiratory tract infection, tracheitis, also there is certain treatment diabetes effect.

Herba Houttuyniae heat-clearing and toxic substances removing in we, having the effect of relieving cough and asthma, antibacterial, antiinflammatory, antiviral, enhancing human body immunity power (especially diabetics resistance declines), is the merit of monarch drug in side, row eliminating heat from the lung, lung qi dispersing cough-relieving; Radix Astragali benefiting QI for strengthening the superficies is ministerial drug in side, auxiliary monarch drug QI invigorating invigorating middle warmer, enhancing human body immunity power, and has the effect for the treatment of diabetes; Folium Eriobotryae, Semen Armeniacae Amarum, Radix Peucedani, Rhizoma Pinelliae Preparatum, seven lotuses be adjuvant drug in the side of being altogether, and principal drug assistance plays that dispelling wind is relievingd asthma, the merit of lung qi dispersing cough-relieving; Adjuvant in Radix Asteris, the Pericarpium Citri Reticulatae side of being, plays the merit of relieving cough and resolving phlegm altogether; Add Folium Perillae, Radix Saposhnikoviae, expelling wind and cold, disease serious for affection of exogenous wind-cold, can wind and cold be dispersed, only headache.

Technical solution of the present invention meets the mechanism of tcm treatment according to syndrome differentiation, bases oneself upon the origin of disease, reasonable recipe science.

The Chinese medicine composition of a kind of relieving cough and asthma provided by the invention has the following advantages:

1, compositions provided by the invention and safe and effective, has heat-clearing and toxic substances removing, lung qi dispersing cough-relieving, resolving phlegm and relieving asthma effect, has better therapeutic effect to exogenous cough, upper respiratory tract infection and bronchitis.

2, Traditional Chinese medicine composition formula of the present invention is rationally innovated, and production cost is low, technique is simple.

3, compositions provided by the invention, can strengthen the resistance of diabetics, treat caused by diabetic complication cough, respiratory tract infection, tracheitis.

Detailed description of the invention

The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.

Embodiment 1 syrup

Get Herba Houttuyniae 8kg, Radix Astragali 8kg, Folium Eriobotryae 6kg part, Semen Armeniacae Amarum 6kg, Radix Asteris 6kg part, Pericarpium Citri Reticulatae 6kg part, Radix Peucedani 6kg, seven lotus 6kg, Rhizoma Pinelliae Preparatum 6kg, Folium Perillae 5kg, Radix Saposhnikoviae 5kg.By above-mentioned 11 taste medical materials, extracting in water 2 times, twice amount of water is respectively 10 times, 8 times of medical material gross weight, and the extracted twice time is respectively 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10.In extractum, add syrup adjuvant sucrose, sorbic acid, water stirs, obtained syrup.

Embodiment 2 tablet

Get Herba Houttuyniae 20kg, Radix Astragali 20kg, Folium Eriobotryae 20kg part, Semen Armeniacae Amarum 15kg, Radix Asteris 20kg part, Pericarpium Citri Reticulatae 20kg part, Radix Peucedani 20kg, seven lotus 20kg, Rhizoma Pinelliae Preparatum 20kg, Folium Perillae 6kg, Radix Saposhnikoviae 15kg.By above-mentioned 11 taste medical materials, with 40% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount, 3 hours, 2 hours, 1 hour respectively extraction time, merge extractive liquid, filters, and when filtrate concentrates 60 DEG C, relative density is the extractum of 1.25, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.

Embodiment 3 mixture

Get Herba Houttuyniae 10kg, Radix Astragali 10kg, Folium Eriobotryae 10kg, Semen Armeniacae Amarum 10kg, Radix Asteris 10kg, Pericarpium Citri Reticulatae 10kg, Radix Peucedani 10kg, seven lotus 10kg, Rhizoma Pinelliae Preparatum 10kg, Folium Perillae 10kg, Radix Saposhnikoviae 10kg.By above-mentioned 11 taste medical materials, extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, 3 hours, 2 hours, 1 hour respectively each extraction time, merge extractive liquid, filter, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.20, adds ethanol, makes alcohol content be 40%, leave standstill 24 hours, filter, it is the extractum of 1.10 that filtrate is concentrated into relative density when filtrate is concentrated into 70 DEG C, adds 3 times that purified water ad pond om is medical material gross weight, fill, obtains mixture of the present invention.

Add syrup adjuvant sucrose, ethyl ester, water, vegetable oil stir, obtained syrup.

Embodiment 4 tablet

Get Herba Houttuyniae 15kg, Radix Astragali 15kg, Folium Eriobotryae 15kg, Semen Armeniacae Amarum 12kg, Radix Asteris 15kg, Pericarpium Citri Reticulatae 15kg, Radix Peucedani 15kg, seven lotus 15kg, Rhizoma Pinelliae Preparatum 15kg, Folium Perillae 20kg, Radix Saposhnikoviae 20kg, by above-mentioned 11 taste medical material alcohol reflux 2 times, each concentration of alcohol is respectively 80%, 60%, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, extraction time is respectively 4 hours, 3 hours, merge extractive liquid, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.10, add supplementary product starch, ethanol, Pulvis Talci, obtained tablet.

Embodiment 5 capsule

Get Herba Houttuyniae 5kg, Radix Astragali 5kg, Folium Eriobotryae 5kg, Semen Armeniacae Amarum 5kg, Radix Asteris 10kg, Pericarpium Citri Reticulatae 15kg, Radix Peucedani 15kg part, seven lotus 15kg, Rhizoma Pinelliae Preparatum 15kg, Folium Perillae 15kg, Radix Saposhnikoviae 15kg.By above-mentioned 11 taste medical materials, extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, merge extractive liquid, filters, and when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.25, add supplementary product starch, ethanol, dextrin, magnesium stearate, incapsulate shell, obtained capsule.

Embodiment 6 granule

Get Herba Houttuyniae 5kg, Radix Astragali 15kg, Folium Eriobotryae 15kg, Semen Armeniacae Amarum 5kg, Radix Asteris 5kg, Pericarpium Citri Reticulatae 5kg, Radix Peucedani 5kg part, seven lotus 5kg, Rhizoma Pinelliae Preparatum 5kg, Folium Perillae 8kg, Radix Saposhnikoviae 8kg.By above-mentioned 11 taste medical materials, extracting in water 2 times, each amount of water is equivalent to 12 times, 10 times of medical material gross weight respectively, each extraction time is respectively 3 hours, 2 hours, merge extractive liquid, filters, it is the clear paste of 1.05 that filtrate is concentrated into relative density at 80 DEG C, add ethanol, make alcohol content be 70%, leave standstill 12 hours, filter, when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.25, adds adjuvant Icing Sugar, starch, dextrin, ethanol, obtained granule.

pharmacodynamics test

Ammonia is caused to the impact of mouse cough

1 material

1.1 laboratory animal cleaning grade Male Kunming strain mice 50, weight 18 ~ 22g, is provided by Guangxi Medical University's animal center.Feeding environment: room temperature 20-23 DEG C, relative humidity 45% ~ 6o%, cage tool peracetic acid soln is sterilized, and drinking water is for purifying waste water.

1.2 medicines and reagent

Embodiment 3 medicament (crude drug content 1.1g/mL);

FUFANG GANCAO PIAN ((traditional Chinese medicines Zhun Zi H12020802 Tianjin Lisheng Pharmaceutical Co., Ltd. lot number 0611158);

Ammonia (analytical pure), Tianjin chemical reagent three factory produces.

2 methods

2.1 groupings and administration only get Male Kunming strain mice 5O, are divided into 5 groups at random, i.e. dosage group, embodiment 3 high dose group and FUFANG GANCAO PIAN group in blank group, embodiment 3 low dose group, embodiment 3, only often organize each 1O.The basic, normal, high dosage component of embodiment 3 not by crude drug 2 (be equivalent to be grown up quantity 4.5 times), 4 (are equivalent to be grown up quantity 8 times), 8g/kg (be equivalent to be grown up quantity 18 times) and FUFANG GANCAO PIAN group by crude drug 0.4g/kg (being equivalent to 18 times of adult's quantity), capacity presses 0.2ml/10g gastric infusion; Blank group gives isometric(al) pure water gavage.Equal every day 1 time, continuous 7d.

30min after 2.2 operation last administrations, is placed in inverted 500mL beaker by each group of mice respectively, inside puts a cotton balls, draw ammonia with 1mL syringe, 0.2mL injects cotton balls, is inverted beaker rapidly, in order to avoid Leakage Gas, observe and record cough number of times in mouse cough incubation period and 3min.

3 results are respectively organized cough number of times in mouse cough incubation period and 3min and are compared in table 1.

Table 1 respectively group mouse cough incubation period and 3min interior cough number of times compares (x ± s)

Compare with blank group, * P<0.05, * * P<0.01

From table 1, the basic, normal, high dosage group of embodiment 3 and FUFANG GANCAO PIAN group mouse cough all comparatively blank group prolongation (P<0.05 incubation period, P<0.01), in 3min, cough number of times reduces (P<0.05, P<0.01).

clinical trial is summed up

1 case selection

500 examples all meet Chinese medical discrimination and belong to exogenous cough.Wherein outpatient 437 example, inpatient 63 example; Minimum 6 years old of age, maximum 65 years old.Man 248 example, female 252 example.

2 Therapeutic Method

Take the embodiment of the present invention 6 medicament, companion's pharyngalgia hoarseness person adds Fructus Arctii, Flos Lonicerae; The inclined severe one of wind and cold adds Folium Perillae, Radix Saposhnikoviae.10ml/ time, 3-4 time/every day, onset in 3-5 days, healing in about 7 days

3 therapeutic outcomes

Cure (disappearance of symptom, sign, follows up a case by regular visits to and do not recur for 2 months) 243 examples, effectively (symptom and sign disappears substantially) 211 is routine, and invalid (symptom and sign is without change or increase the weight of) 46 is routine, and total effective rate is 90.8%.

4 medical record citings

Zeng, man, 10 years old, on June 26th, 2010 examined.Cough 3 days, without expectorant, mild nasal congestion.Body is looked into: without heating, and two pulmonary respiration sound increases thick, without rale.Deep red tongue, yellow and thin fur, thready pulse is number slightly.Examine as cough due to pathogenic wind-heat, control with heat-clearing and toxic substances removing, lung qi dispersing cough-relieving, prescription the present embodiment 5 medicament, take healing on the 3rd, visit and do not recur for 3 months.

Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.

Claims (8)

1. a Chinese medicine composition for relieving cough and asthma, is characterized in that it is prepared from by the raw material comprising following weight portion: Herba Houttuyniae 5-20 part, Radix Astragali 5-20 part, Folium Eriobotryae 5-20 part, Semen Armeniacae Amarum 5-15 part, Radix Asteris 5-20 part, Pericarpium Citri Reticulatae 5-20 part, Radix Peucedani 5-20 part, seven lotus 5-20 parts, Rhizoma Pinelliae Preparatum 5-20 part, Folium Perillae 5-20 part, Radix Saposhnikoviae 5-20 part.

2. the Chinese medicine composition of relieving cough and asthma as claimed in claim 1, is characterized in that it is prepared from by the raw material comprising following weight portion: Herba Houttuyniae 8-15 part, Radix Astragali 8-15 part, Folium Eriobotryae 6-15 part, Semen Armeniacae Amarum 6-12 part, Radix Asteris 6-15 part, Pericarpium Citri Reticulatae 6-15 part, Radix Peucedani 6-15 part, seven lotus 6-15 parts, Rhizoma Pinelliae Preparatum 6-15 part, Folium Perillae 6-15 part, Radix Saposhnikoviae 6-15 part.

3. the Chinese medicine composition of relieving cough and asthma as claimed in claim 1, is characterized in that it is prepared from by the raw material comprising following weight portion: Herba Houttuyniae 10 parts, the Radix Astragali 10 parts, Folium Eriobotryae 10 parts, Semen Armeniacae Amarum 10 parts, Radix Asteris 10 parts, Pericarpium Citri Reticulatae 10 parts, Radix Peucedani 10 parts, 10 parts, seven lotuses, Rhizoma Pinelliae Preparatum 10 parts, Folium Perillae 10 parts, Radix Saposhnikoviae 10 parts.

4. the Chinese medicine composition as described in claim 1-3 any one, is characterized in that its active component adopts the alcohol reflux of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.

5. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 11 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filters, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.10-1.25, obtains active component.

6. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 11 taste medical materials, extracting in water 2-3 time, each amount of water is equivalent to the 6-12 of medical material gross weight doubly, each extraction time is 1-3 hour, merge extractive liquid, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the clear paste of 1.05-1.20, adds ethanol, makes alcohol content be 40-70%, leave standstill 12-24 hour, filter, when filtrate is concentrated into 70-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.

7. Chinese medicine composition as claimed in claim 4, it is characterized in that its active component is prepared from by the following method: get whole 11 taste medical materials, with 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, merge extractive liquid, filters, when filtrate is concentrated into 60-80 DEG C, relative density is the extractum of 1.10-1.25, obtains active component.

8. a Chinese medicine composition for relieving cough and asthma, comprises acceptable carrier in the Chinese medicine composition of the relieving cough and asthma any one of claim 1-3 and pharmaceuticals industry.