CN103599341B - A kind of pharmaceutical composition for the treatment of cough with asthma - Google Patents
A kind of pharmaceutical composition for the treatment of cough with asthma Download PDFInfo
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- CN103599341B CN103599341B CN201310532693.4A CN201310532693A CN103599341B CN 103599341 B CN103599341 B CN 103599341B CN 201310532693 A CN201310532693 A CN 201310532693A CN 103599341 B CN103599341 B CN 103599341B
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Abstract
The invention discloses a kind of pharmaceutical composition for the treatment of cough with asthma, be made up of the Chinese medicinal components of following weight portion: Radix Platycodonis 10-40 part, Semen Ginkgo 10-30 part, Rhizoma Anemarrhenae 10-30 part, Semen Sinapis Albae 5-20 part, Ramulus Cinnamomi 5-15 part, Rhizoma Cynanchi Stauntonii 5-10 part, Radix Glycyrrhizae 2-10 part.The present invention, on the basis of Chinese medicine traditional theory, in conjunction with medication experience among the people, uses modern scientific theory formulated, can warming the lung sending down the abnormal ascending QI, effect, the relieving cough and asthma Be very effective such as have warming the lung, sending down the abnormal ascending QI, eliminate the phlegm.
Description
Technical field
The invention belongs to medicine field, relate to a kind of pharmaceutical composition for the treatment of cough with asthma.
Background technology
Chinese medicine is the product of the distinctive Chinese medical theory of China and practice, and aboundresources is with a long history, is the pure natural organic material that the mankind apply the earliest, has the two-way function of nutrition and treatment concurrently.
Coughing, panting is clinical common sympton, can cause by flu, bronchitis etc. are sick, no matter men and women, old and young, all can fall ill throughout the year, patients pool, especially easily send out when season or weather convert with elderly and infirm, ill have the symptom such as bottleneck throat pruritus, discomfort, rough abundant expectoration, hypopnea often, has a strong impact on rest, life.At present, though the medicine for the treatment of this type of disease is clinically many, curative effect is not fully up to expectations.Doctor trained in Western medicine adopts the expelling phlegm drugs such as antitussive medicine and the ammonium chloride symptomatic treatments such as codeine to symptoms such as coughing, pant, though can accomplish temporarily to control symptom, must merge antibacterials such as using antibiotic to reach healing object.And antibiotic abuse can cause more serious consequence, the cough that some chronic bronchitis causes is unsuitable life-time service antibiotic therapy also.Chinese medicine has more deep understanding to the pathology and disease mechanism of coughing, panting, obvious advantage is had in its treatment, but also do not find in curative effect and market all compared with the kind of tool advantage at present, if on the basis of theory of Chinese medical science, give full play to the advantage of Chinese medicine, develop the medicine of better efficacy, good Social and economic benef@can be obtained.There is more research to treatment disease of cough and asthma class Chinese medicine at present, but there is not yet the pharmaceutical composition report of Radix Platycodonis, Semen Ginkgo, the Rhizoma Anemarrhenae, Semen Sinapis Albae, Ramulus Cinnamomi, Rhizoma Cynanchi Stauntonii, Radix Glycyrrhizae.
(1) Radix Platycodonis is the dry root of Campanulaceae Radix Platycodonis Platycodongrandiflorum (Jacq.) A.DC.." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are bitter, pungent, flat.Return lung meridian.[function with cure mainly] lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness.
(2) Semen Ginkgo is the dry mature seed of Ginkgoaceae plant Ginkgo biloba GinkgobilobaL..Gather during seed maturity in autumn, removing meat episperm, cleans, and slightly steams or after slightly boiling, dries." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, bitter, puckery, put down; Poisonous.Return lung meridian.[function with cure mainly] astringing lung QI for relieving asthma, leukorrhagia stopping is turbid, urine reducing.Breath with cough for abundant expectoration, leukorrhagia nebulousurine, the enuresis, frequent micturition.
(3) Rhizoma Anemarrhenae is the dry rhizome of liliaceous plant Rhizoma Anemarrhenae AnemarrhenaasphodeloidesBge..Season in spring and autumn two excavates, and removing fibrous root and silt, dry." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are bitter, sweet, cold.Return lung, stomach, kidney channel.[function with cure mainly] clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.For fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, dryness of the intestine constipation.
(4) Semen Sinapis Albae is the dry mature seed of crucifer Caulis et Folium Sinapis albee Brassicaalba (L.) Boiss." Chinese Pharmacopoeia " version in 1963 is recorded: [nature and flavor] are pungent, warm.[function with cure mainly] distending pain in the chest and hypochondrium, phlegm dyspnea is coughed, and regurgitation is vomitted, carbuncle of yin nature sucutaneous nodule.
(5) Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi CinnamomumcassiaPresl.Spring, Xia Erji gather, and except defoliation, dry, or section is dried." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.[function with cure mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
(6) Rhizoma Cynanchi Stauntonii is dry rhizome and the root of Asclepiadaceae plant rhizoma et radix cynanchi stauntoni Cynanchumstauntonii (Decne.) Schltr.exLevl. or leaves of Daphne genkwa Rhizoma Cynanchi Stauntonii Cynanchumglaucescens (Decne.) Hand.-Mazz..Autumn excavates, and cleans, dries." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are pungent, bitter, tepor.Return lung meridian.[function with cure mainly] sending down the abnormal ascending QI, expectorant, cough-relieving.Stop up real for lung qi, cough with copious phlegm, fullness in the chest dyspnea with rapid respiration.
(7) Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume GlycyrrhizauralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. GlycyrrhizaglabraL..Spring, Qiu Erji excavate, and removing fibrous root, dries." Chinese Pharmacopoeia " version in 2010 is recorded: [nature and flavor with return through] are sweet, flat.GUIXIN, lung, spleen, stomach warp.[function with cure mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of cough with asthma, said composition energy warming the lung sending down the abnormal ascending QI, relieving cough and asthma, expectorant effect is good.
The technical solution adopted in the present invention is as follows:
Treat a pharmaceutical composition for cough with asthma, be made up of the Chinese medicinal components of following weight portion: Radix Platycodonis 10-40 part, Semen Ginkgo 10-30 part, Rhizoma Anemarrhenae 10-30 part, Semen Sinapis Albae 5-20 part, Ramulus Cinnamomi 5-15 part, Rhizoma Cynanchi Stauntonii 5-10 part, Radix Glycyrrhizae 2-10 part.
The pharmaceutical composition of the above treatment cough with asthma, can be prepared into pharmaceutically acceptable any preparation, as: powder, granule (electuary), pill, tablet, capsule, decoction, soft extract, mixture (comprising oral liquid), syrup, tea-drinking etc.Consider cough, pant patient because of throat, esophagus uncomfortable, swallow general solid preparation may have any problem, the soft extract that preferred mouthfeel is good, syrup, mixture, oral liquid etc., taking rear section medicine can direct effect or residue in throat, esophagus, onset is rapid, can comparatively fast alleviate bottleneck throat malaise symptoms.
Treat the preparation method of the pharmaceutical composition soft extract of cough with asthma described in more than one, the weight portion of each raw medicinal material of soft extract is: Radix Platycodonis 10-40 part, Semen Ginkgo 10-30 part, Rhizoma Anemarrhenae 10-30 part, Semen Sinapis Albae 5-20 part, Ramulus Cinnamomi 5-15 part, Rhizoma Cynanchi Stauntonii 5-10 part, Radix Glycyrrhizae 2-10 part;
Preparation method is: distillate is produced in the distillation that adds water of Semen Ginkgo, Semen Sinapis Albae, Ramulus Cinnamomi; Medicinal residues and Radix Platycodonis, the Rhizoma Anemarrhenae, Rhizoma Cynanchi Stauntonii, Radix Glycyrrhizae decoct with water 2 times, each 2 hours, collecting decoction, and filter, hold over night, gets supernatant and be evaporated to thick paste.Separately get sucrose and make refined honey, add above-mentioned thick paste and refined honey, be concentrated into appropriate, let cool, add above-mentioned distillate, stir evenly, to obtain final product.
As the present invention is made syrup or mixture, its preparation method is: get Semen Ginkgo, the distillation that adds water of Semen Sinapis Albae, Ramulus Cinnamomi produces distillate; Medicinal residues and Radix Platycodonis, the Rhizoma Anemarrhenae, Rhizoma Cynanchi Stauntonii, Radix Glycyrrhizae decoct with water 2 times, each 2 hours, collecting decoction, filter, hold over night, get supernatant concentration, add suitable amount of sucrose and antiseptic, boil and make dissolving, filter, let cool, add above-mentioned distillate, add water appropriate, stir evenly, to obtain final product.
The present invention is on the basis of Chinese medicine traditional theory, in conjunction with medication experience among the people, uses modern scientific theory formulated.The treatment that the invention has the beneficial effects as follows: various respiratory system disease can be widely used in, comprise cough, pant etc., the effect such as there is warming the lung, sending down the abnormal ascending QI, eliminate the phlegm, relieving cough and asthma Be very effective, and taking dose is little, production technology is simple, moderate cost, is beneficial to consumer and takes.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but do not limit the scope of the invention and range of application:
One, the preparation of soft extract
Embodiment 1
Treat a preparation method for the pharmaceutical composition soft extract of cough with asthma, the weight of each raw medicinal material of soft extract is: Radix Platycodonis 1kg, Semen Ginkgo 1kg, Rhizoma Anemarrhenae 1kg, Semen Sinapis Albae 0.5kg, Ramulus Cinnamomi 0.5kg, Rhizoma Cynanchi Stauntonii 0.5kg, Radix Glycyrrhizae 0.2kg;
Preparation method is: distillate is produced in the distillation that adds water of Semen Ginkgo, Semen Sinapis Albae, Ramulus Cinnamomi; Medicinal residues and Radix Platycodonis, the Rhizoma Anemarrhenae, Rhizoma Cynanchi Stauntonii, Radix Glycyrrhizae add 8 times amount soak by water 2 times, each 2 hours, collecting decoction, filter, hold over night, gets supernatant and is evaporated to relative density 1.25(60 DEG C) thick paste.Separately get sucrose 5kg, make refined honey, add above-mentioned thick paste and refined honey 0.5kg, be concentrated into appropriate, let cool, add above-mentioned distillate, stir evenly, make 10kg, to obtain final product.
Embodiment 2
Treat a preparation method for the pharmaceutical composition soft extract of cough with asthma, the weight of each raw medicinal material of soft extract is: Radix Platycodonis 4kg, Semen Ginkgo 3kg, Rhizoma Anemarrhenae 3kg, Semen Sinapis Albae 2kg, Ramulus Cinnamomi 1.5kg, Rhizoma Cynanchi Stauntonii 1kg, Radix Glycyrrhizae 1kg;
Preparation method is: distillate is produced in the distillation that adds water of Semen Ginkgo, Semen Sinapis Albae, Ramulus Cinnamomi; Medicinal residues and Radix Platycodonis, the Rhizoma Anemarrhenae, Rhizoma Cynanchi Stauntonii, Radix Glycyrrhizae add 8 times amount soak by water 2 times, each 2 hours, collecting decoction, filter, hold over night, gets supernatant and is evaporated to relative density 1.35(60 DEG C) thick paste.Separately get sucrose 5kg, make refined honey, add above-mentioned thick paste and refined honey 1kg, be concentrated into appropriate, let cool, add above-mentioned distillate, stir evenly, make 10kg, to obtain final product.
Embodiment 3
Treat a preparation method for the pharmaceutical composition soft extract of cough with asthma, the weight of each raw medicinal material of soft extract is: Radix Platycodonis 2kg, Semen Ginkgo 2kg, Rhizoma Anemarrhenae 1.5kg, Semen Sinapis Albae 1kg, Ramulus Cinnamomi 1kg, Rhizoma Cynanchi Stauntonii 0.8kg, Radix Glycyrrhizae 0.5kg;
Preparation method is: distillate is produced in the distillation that adds water of Semen Ginkgo, Semen Sinapis Albae, Ramulus Cinnamomi; Medicinal residues and Radix Platycodonis, the Rhizoma Anemarrhenae, Rhizoma Cynanchi Stauntonii, Radix Glycyrrhizae add 8 times amount soak by water 2 times, each 2 hours, collecting decoction, filter, hold over night, gets supernatant and is evaporated to relative density 1.30(60 DEG C) thick paste.Separately get sucrose 5kg, make refined honey, add above-mentioned thick paste and refined honey 0.8kg, be concentrated into appropriate, let cool, add above-mentioned distillate, stir evenly, make 10kg, to obtain final product.
Two, pharmacodynamics test
By the above-mentioned soft extract embodiment 1-3 sample prepared, for pharmacodynamics test.
Results of animal shows, this product all demonstrates certain protective effect to the mortality rate after mouse infection staphylococcus aureus, Hemolytic streptococcus and klepsiella pneumoniae; On Carrageenan causes mice pedal swelling inflammation and granuloma induced by implantation of cotton pellets chronic inflammatory disease also has obvious inhibitory action; There is obvious prolongation effect incubation period ammonia being caused to mouse cough, and obviously can suppress its cough number of times, and also there is obvious prolongation effect incubation period citric acid being sprayed to guinea pig cough, and obviously can suppress its cough number of times; The phenol red secretion test of mice also shows that it has obvious resolve phlegm effect.In addition guinea pig bronchial spastic contractions is caused also to demonstrate certain inhibitory action to histamine.
Above result of the test shows that this product has relieving cough and resolving phlegm, relievings asthma, antiinflammatory, antianaphylactic effect.
Three, acute toxicity test
By the above-mentioned soft extract embodiment 1-3 sample prepared, for acute toxicity test.
In mice 24 hours, gavage gives this soft extract and reaches 225 times that 165g crude drug/kg(is equivalent to people's quantity 42.3g crude drug/60kg), have no it and have anomalous effects to situations such as mice activity, defecation and psychoreactions, on Mouse Weight increase also there are no impact, during administration and viewing duration also without animal dead.Therefore, think that this soft extract acute toxicity is lower.
Four, long term toxicity test
By the above-mentioned soft extract embodiment 1-3 sample prepared, for long term toxicity test.
Getting Wistar rat is test group.Each rats in test groups give respectively dosage be 50,25, this soft extract of 10g crude drug/kg (be equivalent to about respectively 60,30,15 times that people intends consumption clinical day), continuous gastric infusion 4 weeks, carries out the research of this syrup long term toxicity.Result of the test shows, this syrup high dose group (60 times), middle dosage group (30 times) and low dose group (15 times) each observation index compare with blank group, have been showed no obvious abnormal change.
Long term toxicity test result shows, this product is safe by the clinical dosage drafted, route of administration and the application course for the treatment of.
Five, clinical trial
1. case selection standard
Primary symptom: cough with copious phlegm, breathes hard and pants.
Secondary disease: itching throat or pain, chest pain, wheezing, nasal obstruction, watery nasal discharge, floating and tense pulse or cunning.
Possess above primary symptom one, secondary disease 2, the age 18-65 year person.
2. therapeutic scheme
Administrated method: by the above-mentioned soft extract embodiment 1-3 sample prepared, for clinical trial.Oral, a 10g, 3 times on the one.The course for the treatment of: medication 7 days.
3. curative effect determinate standard
Clinical recovery: clinical symptoms, sign disappear or substantially disappear, integration reduces more than 95%.
Effective: clinical symptoms, sign are obviously improved, integration reduces between 70% ~ 94%.
Effective: clinical symptoms, sign all take a favorable turn, integration reduces at 30% ~ <69%.
Invalid: clinical symptoms is not improved, very then increase the weight of, integration reduces <30%.
Computing formula is: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%
Observing time window: enter front 1st observation of group and collection of specimens before administration in 1 day; Medication terminates rear detection and completed in 3 days.
Product curative effect survey result table
Result: recovery from illness 70%, effective 20.8%, effective 8%, invalid 1.2%.Clinical test results shows: adopt the present invention to treat the pharmaceutical composition of cough with asthma, and use safety, effectively, to cough with copious phlegm, breathing hard to pant has good curative effect.
Claims (2)
1. treat a pharmaceutical composition for cough with asthma, it is characterized in that, be made up of the Chinese medicinal components of following weight portion: Radix Platycodonis 10-40 part, Semen Ginkgo 10-30 part, Rhizoma Anemarrhenae 10-30 part, Semen Sinapis Albae 5-20 part, Ramulus Cinnamomi 5-15 part, Rhizoma Cynanchi Stauntonii 5-10 part, Radix Glycyrrhizae 2-10 part.
2. treat the pharmaceutical composition of cough with asthma according to claim 1, it is characterized in that, described pharmaceutical composition makes powder, granule, pill, tablet, capsule, decoction, soft extract or oral liquid.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1338268A (en) * | 2000-08-16 | 2002-03-06 | 黄中弟 | Anticough lung-moistening jelly and its preparing process |
| CN102362754A (en) * | 2011-11-08 | 2012-02-29 | 温民 | Medicinal pillow with effects of relieving cough and asthma |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1338268A (en) * | 2000-08-16 | 2002-03-06 | 黄中弟 | Anticough lung-moistening jelly and its preparing process |
| CN102362754A (en) * | 2011-11-08 | 2012-02-29 | 温民 | Medicinal pillow with effects of relieving cough and asthma |
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Address after: 530104 the Guangxi Zhuang Autonomous Region Nanning city Wuming Yilin Development Zone Patentee after: GUANGXI MAIKE JIANFENG PHARMACEUTICAL CO., LTD. Address before: 530104 the Guangxi Zhuang Autonomous Region Nanning city Wuming Yilin Development Zone Patentee before: Guangxi Jianfeng Pharmaceutical Co., Ltd. |
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Granted publication date: 20151125 Termination date: 20181031 |