CN109316551A - A kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of Chinese medicine compositions for treating acpuei pharyngitis, are mainly made of radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae and Radix Glycyrrhizae, and the Chinese medicine composition has effects that clearing heat and detoxicating, enriching yin clearing lung-heat, dispelling phlegm and relieving sore-throat.Radix scutellariae is bitter, cold in side, enters lung, stomach, large intestine channel, there is the function of heat-clearing and damp-drying drug, purging fire for removing toxin, catechu can clearing heat and eliminating phlegm, the two compatibility is monarch drug in a prescription altogether；Fructus Forsythiae reinforces the clearing heat and detoxicating function of monarch drug in a prescription, and campanulaceae promoting the dispersing function of the lung relieving sore-throat eliminating the phlegm is ministerial drug；Radix polygonati officinalis, Radix Ophiopogonis nourishing Yin and moistening lung, glutinous rehmannia, radix scrophulariae clearing heat and nourishing yin are adjutant altogether, and giving consideration to both the incidental and fundamental is uncharmed with helping；Radix Glycyrrhizae is clearing heat and detoxicating, moistening lung to arrest cough and can coordinating the drug actions of a prescription be adjuvant；All medicines share plays the effect of clearing heat and detoxicating, enriching yin clearing lung-heat, dispelling phlegm and relieving sore-throat altogether, curative for effect for cough and acpuei pharyngitis caused by lung heat.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, are related to a kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis,
More particularly to a kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis caused by lung heat.
Background technique
Pharyngitis is a kind of illness that the mankind are common, high-incidence, is clinically referred to as to can not be cured chronic disease, is prevented in the past in medicine
Do not paid attention in treatment, in addition without corresponding treatment method and drug, still continues to use over one when being allowed to clinically treat
As anti-inflammatory treatment, good curative effect cannot be obtained, pharyngitis inflammation general absolutely not is treated with conventional anti-inflammatory, detoxicating, will not be obtained
Good effect.
Pharyngitis be divided into it is acute with it is chronic: acpuei pharyngitis (acute pharyngitis) is pharynx mucous membrane, and is involved under mucous membrane
And the acute inflammation of lymphoid tissue, often secondary to after acute rhinitis or acute tonsil or be one of infection of the upper respiratory tract portion
Point.Also often be the topical manifestations of general disease or be acute infectious disease premonitory symptom.Acpuei pharyngitis recurrent exerbation is easy conversion
At chronic pharyngitis, chronic pharyngitis is clinically a kind of common disease, frequently-occurring disease, more obstinate in conventional drug therapy, and
Recurrent exerbation.
With the improvement of people ' s living standards with the aggravation of a series of environmental problem such as the increase of pressure and haze,
The number of the infected of pharyngitis gradually increases, and seriously affects normal work and life during falling ill.Therefore pharyngitis prevention and control
Treatment seems more important, and exploitation is more used for the drug for the treatment of pharyngitis, is not only able to satisfy needed for clinic, generates direct economic effect
Benefit, and patient health situation can be improved, population health level is improved, extensive social benefit is generated.
Patent CN106620202 discloses a kind of Chinese herbs decoction for treating acpuei pharyngitis, is added by the drug of following parts by weight
Decocting system forms: 20-30 parts of gypsum, 10-15 parts of radix scutellariae, 10-15 parts of radix scrophulariae, 10-15 parts of achyranthes aspera, 10-15 parts of bulb of thunberg fritillary, complete
10-15 parts of Snakegourd Fruit, 8-12 parts of blackberry lily, 8-12 parts of radix paeoniae rubra, 8-12 parts of Chinese olive, 5-10 parts of peppermint, 3-6 parts of Radix Glycyrrhizae, 5-10 parts of the root bark of tree peony.
Patent CN104721510A discloses a kind of acpuei pharyngitis removing toxic substances analgetic preparation, takes the main original of following weight proportions
Material is prepared: 12-17 parts of rhizoma anemarrhenae, 9-14 parts of blackberry lily, 12-16 parts of bulbus fritillariae cirrhosae, half 10-13 parts of umbrella, 13-16 parts of sowthistle,
8-15 parts of radix cynanchi atrati, 12-16 parts of peppermint, 12-16 parts of Chinese milkwort herb, 10-14 parts of mulberry leaf, 9-15 parts of persimmon sugar, 8-16 parts of Herba lygodii,
11-17 parts of Herba Hyperici Monogyni, 11-15 parts of fringed iris, 11-15 parts of delavay falsepanax herb, 12-17 parts of resina populi.
Patent CN103041160B provides a kind of Chinese medicine composition for treating acpuei pharyngitis, the original of the Chinese medicine composition
Expect that medicine includes Glabrous Sarcandra Herb, polygonum cuspidate, rhizoma acori graminei, leatherleaf mahonia, the sterculia seed, radix scutellariae, cicada slough, Dioscorea Panthcica, aster, sophora flower, Chinese gall, pig
Tooth soap, goldenrod, indigo naturalis, Chinese ephedra, panax japonicus majoris, radix polygonati officinalis, sea-buckthorn, myrobalan, radix scrophulariae, caulis piperis futokadsurae, panax japonicus, Lasiosphaera fenzlii, adenophora tetraphylla,
Chinese yam, catechu, Radix Glycyrrhizae.
Patent CN103585336A disclose it is a kind of for treating the pharmaceutical composition of acpuei pharyngitis, by following raw material
Proportion is prepared: 0.5-1.5 parts of great burdock achene, 8-12 parts of borax, 8-12 parts of campanulaceae, 8-12 parts of indigo naturalis, 2-4 parts of wild chrysanthemum, thin
4-8 parts of lotus, 4-6 parts of Cortex Phellodendri, 2-4 parts of Radix Glycyrrhizae, 2-4 parts of borneol.
Inventor by long-term research and practice, obtains unexpectedly a kind of Chinese medicine composition, and existing
Prescriptions of traditional Chinese medicine difference is very big, and party's raw material is simple and easy to get, is not only able to safely and efficiently treat acpuei pharyngitis caused by lung heat, also
It can anti-inflammatory, antipyretic, strengthen immunity.In addition, inventor also explores the preparation method of the Chinese medicine composition, medicine is not being influenced
Under the premise of effect and stability, different Chinese medicines is handled simultaneously, preparation process is largely simplified, saves into
This, obtains easy to use, the higher two kinds of preparations of patient dependence.
Summary of the invention
It is anxious caused by treatment acpuei pharyngitis especially lung heat the object of the present invention is to provide a kind of new Chinese medicine composition
Property pharyngitis has good curative effect.Furthermore it is also an object that providing the preparation method of the drug.
In order to realize above-mentioned purpose of the invention, the following technical scheme is adopted:
The present invention provides a kind of Chinese medicine composition for treating acpuei pharyngitis caused by lung heat, and described pharmaceutical composition is by following
Medicinal material is prepared: radix scutellariae 250-350 parts by weight, catechu 150-300 parts by weight, Fructus Forsythiae 250-350 parts by weight, campanulaceae 30-100
Parts by weight, radix polygonati officinalis 50-120 parts by weight, Radix Ophiopogonis 100-250 parts by weight, glutinous rehmannia 130-250 parts by weight, radix scrophulariae 200-300 weight
Part, Radix Glycyrrhizae 30-100 parts by weight.
Drug of the invention is to be developed according to theory of traditional Chinese medical science for the pathomechanism of pharyngitis, mainly by radix scutellariae, youngster
Tea, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae and Radix Glycyrrhizae composition, the drug have it is clearing heat and detoxicating, enriching yin clearing lung-heat, dispel
The effect of phlegm relieving sore-throat.
Radix scutellariae bitter in side, it is cold in nature, there is the effect of heat-clearing and damp-drying drug, purging fire for removing toxin, cure mainly cough with lung heat, hyperpyrexia polydipsia；
Catechu bitter, puckery, cold nature has the effect of clearing lung and eliminating phlegm, cures mainly cough with lung heat；Fructus Forsythiae bitter, cold nature have heat-clearing solution
The effect of poison, dispersing swelling and dissipating binds, dispelling wind and heat from the body, cures mainly anemopyretic cold, hyperpyrexia polydipsia；It is campanulaceae bitter, pungent, it is mild-natured, it is distributed in lung channel, have
The effect of promoting the dispersing function of the lung, relieving sore-throat, eliminating the phlegm, apocenosis, cures mainly coughing with a lot of sputum, chest distress, pharyngalgia hoarse voice, lung carbuncle pyemesis；Radix polygonati officinalis is sweet in flavor, property
It is slightly cold, there is the effect of nourishing yin to moisten dryness, promote the production of body fluid to quench thirst, cure mainly lung stomach-Yin wound, cough caused by dryness-heat, dry throat and mouth, Heat Diabetes；Radix Ophiopogonis
Sweet in flavor, slight bitter, cold nature have the effect of nourishing Yin and promoting production of body fluid, moistening lung and clearing away the heart-fire, cure mainly dryness of the lung dry cough, injury thirst, Heat Diabetes；
Glutinous rehmannia is sweet in flavor, bitter, cold in nature, has clearing heat and cooling blood, the effect of fluid dryness, cure mainly acute fever, unconsciousness due to high fever, saliva hurt polydipsia,
Aphthae, abscess of throat, labor heat cough；Radix scrophulariae is sweet in flavor, bitter, salty, cold nature, and there is clearing heat and cooling blood, nourishing yin and lessening fire, removing toxic substances to dissipate
The effect of knot, cures mainly the deep red polydipsia of consumption of YIN caused by febrile disease, tongue, abscess of throat, diphtheria；Radix Glycyrrhizae is sweet in flavor, mild-natured, has clearing heat and detoxicating, eliminating the phlegm
The effect of cough-relieving, coordinating the drug actions of a prescription, cures mainly coughing with a lot of sputum, carbuncle sore tumefacting virus, and can be relieved drug toxicity, strong.
Preferably, described pharmaceutical composition is prepared by following medicinal material: radix scutellariae 300-330 parts by weight, catechu 180-
250g parts by weight, Fructus Forsythiae 300-330 parts by weight, campanulaceae 50-70 parts by weight, radix polygonati officinalis 70-100 parts by weight, Radix Ophiopogonis 150-200 weight
Part, glutinous rehmannia 150-200 parts by weight, radix scrophulariae 250-280 parts by weight, Radix Glycyrrhizae 50-70 parts by weight.
It is highly preferred that described pharmaceutical composition is prepared by following medicinal material: 315 parts by weight of radix scutellariae, 200 weight of catechu
Part, 315 parts by weight of Fructus Forsythiae, 60 parts by weight of campanulaceae, 80 parts by weight of radix polygonati officinalis, 160 parts by weight of Radix Ophiopogonis, 180 parts by weight of glutinous rehmannia, radix scrophulariae
260 parts by weight, 60 parts by weight of Radix Glycyrrhizae.
Preferably, the Chinese medicine composition can be prepared into oral solid formulation or oral liquid.
It is highly preferred that the oral solid formulation is granule, capsule, tablet, further preferably granule.
It is highly preferred that the oral liquid is oral solution or mixture, further preferably oral solution.
Preferably, when the preparation is oral solid formulation, preparation process is as follows:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；Add 6-10 times of water, impregnate 1-3 hours, decocts 1-3 times, it is 2-4 hours each, merge decoction liquor, filtration, merging filtrate；It is cooling
To room temperature, add alcohol to alcohol content up to 35%-55%, cold 12-48 hours heavy, filtration, decompression filtrate recycling ethanol is condensed into leaching
Cream, it is spare；
(2) Sucralose of medicinal extract weight 0.1-0.5% and the dextrin of medicinal extract weight 40-50%, spray preparation process: is added
Mist granulation, routinely preparation process is prepared into oral solid formulation.
It is highly preferred that preparation process is as follows when the preparation is oral solid formulation:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；It decocting 2 times, the steam pressure of extractor is controlled in decoction process in 0.1-0.2Mpa, temperature range is 98-105 DEG C, first
Secondary plus 10 times of amount water impregnate 3 hours, decoct 4 hours；For the second time plus 8 times of amount boiling water decoct 2 hours, merge decoction liquor, filter,
Merging filtrate is cooled to room temperature, and adds alcohol to alcohol content up to 38%, cold 28 hours heavy, filtration, decompression filtrate recycling ethanol is concentrated
The medicinal extract for being 1.15-1.25 at density, it is spare；
(2) preparation process: the Sucralose of addition medicinal extract weight 0.3% and the dextrin of medicinal extract weight 45%, spraying granulation,
Routinely preparation process is prepared into oral solid formulation.
Preferably, when the preparation is oral liquid, preparation process is as follows:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；The 8-10 times of distilled water measured is added for the first time, after impregnating 4-6 hours, boils 3-5 hours, extracts；Second of 6-8 times of addition
Distilled water is measured, is boiled 1-3 hours, is extracted；The 4-6 times of distilled water measured is added in third time, and heating is boiled 1-2 hours, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 110-120 DEG C of hot pressing is gone out
It bacterium 15-35 minutes, packs to get oral liquid.
It is highly preferred that preparation process is as follows when the preparation is oral liquid:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；The distilled water that 9 times of amounts are added for the first time boils 4 hours after impregnating 5 hours, extracts；Second of addition, 7 times of amount distilled water,
It boils 2 hours, extracts；The distilled water of 5 times of amounts is added in third time, and heating is boiled 1.5 hours, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 115 DEG C of pressure sterilizings 25
Minute, it packs to get oral liquid.
Pharmaceutical composition of the present invention the utility model has the advantages that
By the organic compatibility of a variety of drugs in the present invention, treating both manifestation and root cause of disease can not only be directed to etiological treatment, but also fast for symptom
The pain of fast reduction of patient.Radix scutellariae is bitter, cold in side, enters lung, stomach, large intestine channel, there is the function of heat-clearing and damp-drying drug, purging fire for removing toxin, catechu can
Clearing heat and eliminating phlegm, the two compatibility are monarch drug in a prescription altogether；Fructus Forsythiae reinforces the clearing heat and detoxicating function of monarch drug in a prescription, and campanulaceae promoting the dispersing function of the lung relieving sore-throat eliminating the phlegm is ministerial drug；It is beautiful
Bamboo, Radix Ophiopogonis nourishing Yin and moistening lung, glutinous rehmannia, radix scrophulariae clearing heat and nourishing yin are adjutant altogether, and giving consideration to both the incidental and fundamental is uncharmed with helping；Radix Glycyrrhizae is clearing heat and detoxicating, moistening lung
Cough-relieving and energy coordinating the drug actions of a prescription are adjuvant；All medicines share plays the effect of clearing heat and detoxicating, enriching yin clearing lung-heat, dispelling phlegm and relieving sore-throat altogether.Test is aobvious
Show, the traditional chinese medicine composition of the invention treats acpuei pharyngitis caused by lung heat, has a good effect.
Scutelloside contained by radix scutellariae and baicalein can be by interfering arachidonic metabolic pathway, inhibiting cell in side
Activity of the factor etc. generates antipyretic and anti-inflammatory effect；Fragrant solomonseal rhizome polyoses contained by radix polygonati officinalis have immunoregulatory pharmacological activity, Ke Yikang
Scorching, adjusting immunity；There is calm, anticonvulsant effect in Radix Ophiopogonis, and the ophiopogonpolysaccharide contained can promote Hemolysin
It is formed, improves immunity；Glutinous rehmannia can inhibit heat center, have effects that preferably to reduce body temperature, meanwhile, glutinous rehmannia can obviously mention
The synthesis of high lymphocyte DNA and protein enhances low cellular immune function, and the immunity of people can be enhanced, exempt from
In the invasion of virus.
Specific embodiment
To show therapeutic effect of the drug of the present invention to acpuei pharyngitis caused by lung heat, we have done a large amount of experiment and have ground
Study carefully.Technical solution of the present invention is further introduced below in conjunction with specific embodiment, but protection scope of the present invention is not
It is confined to this.
Embodiment 1: the preparation of granule
Prescription:
Radix scutellariae 315kg, catechu 200kg, Fructus Forsythiae 315kg, campanulaceae 60kg, radix polygonati officinalis 80kg, Radix Ophiopogonis 160kg, glutinous rehmannia 180kg,
Radix scrophulariae 260kg, Radix Glycyrrhizae 60kg.
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；It decocting 2 times, the steam pressure of extractor is controlled in decoction process in 0.1-0.2Mpa, temperature range is 98-105 DEG C, first
Secondary plus 10 times of amount water impregnate 3 hours, decoct 4 hours；For the second time plus 8 times of amount boiling water decoct 2 hours, merge decoction liquor, filter,
Merging filtrate is cooled to room temperature, and adds alcohol to alcohol content up to 38%, cold 28 hours heavy, filtration, decompression filtrate recycling ethanol is concentrated
The medicinal extract for being 1.15-1.25 at density, it is spare；
(2) preparation process: the Sucralose of addition medicinal extract weight 0.3% and the dextrin of medicinal extract weight 45%, spraying granulation,
Packing.
Embodiment 2: the preparation of granule
Prescription:
Radix scutellariae 300kg, catechu 180kg, Fructus Forsythiae 300kg, campanulaceae 50kg, radix polygonati officinalis 70kg, Radix Ophiopogonis 150kg, glutinous rehmannia 150kg,
Radix scrophulariae 250kg, Radix Glycyrrhizae 50kg.
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；It decocting 2 times, the steam pressure of extractor is controlled in decoction process in 0.1-0.2Mpa, temperature range is 98-105 DEG C, first
Secondary plus 10 times of amount water impregnate 3 hours, decoct 4 hours；For the second time plus 8 times of amount boiling water decoct 2 hours, merge decoction liquor, filter,
Merging filtrate is cooled to room temperature, and adds alcohol to alcohol content up to 38%, cold 28 hours heavy, filtration, decompression filtrate recycling ethanol is concentrated
The medicinal extract for being 1.15-1.25 at density, it is spare；
(2) preparation process: the Sucralose of addition medicinal extract weight 0.2% and the dextrin of medicinal extract weight 45%, spraying granulation,
Packing.
Embodiment 3: the preparation of granule
Prescription:
Radix scutellariae 330kg, catechu 250kg, Fructus Forsythiae 330kg, campanulaceae 70kg, radix polygonati officinalis 100kg, Radix Ophiopogonis 200kg, glutinous rehmannia 200kg,
Radix scrophulariae 280kg, Radix Glycyrrhizae 70kg.
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；It decocting 2 times, the steam pressure of extractor is controlled in decoction process in 0.1-0.2Mpa, temperature range is 98-105 DEG C, first
Secondary plus 10 times of amount water impregnate 3 hours, decoct 4 hours；For the second time plus 8 times of amount boiling water decoct 2 hours, merge decoction liquor, filter,
Merging filtrate is cooled to room temperature, and adds alcohol to alcohol content up to 38%, cold 28 hours heavy, filtration, decompression filtrate recycling ethanol is concentrated
The medicinal extract for being 1.15-1.25 at density, it is spare；
(2) preparation process: the Sucralose of addition medicinal extract weight 0.4% and the dextrin of medicinal extract weight 45%, spraying granulation,
Packing.
Embodiment 4: the preparation of granule
Prescription:
Radix scutellariae 250kg, catechu 150kg, Fructus Forsythiae 250kg, campanulaceae 30kg, radix polygonati officinalis 50kg, Radix Ophiopogonis 100kg, glutinous rehmannia 130kg,
Radix scrophulariae 200kg, Radix Glycyrrhizae 30kg.
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；Add 10 times of water, impregnate 1 hour, decocts 4 hours, decoction liquor filtration, merging filtrate；It is cooled to room temperature, alcohol to alcohol content is added to reach
35%, cold 12 hours heavy, filtration, decompression filtrate recycling ethanol is condensed into medicinal extract, spare；
(2) preparation process: the Sucralose of addition medicinal extract weight 0.1% and the dextrin of medicinal extract weight 50%, spraying granulation,
Packing.
Embodiment 5: the preparation of granule
Prescription:
Radix scutellariae 350kg, catechu 300kg, Fructus Forsythiae 350kg, campanulaceae 100kg, radix polygonati officinalis 120kg, Radix Ophiopogonis 250kg, glutinous rehmannia
250kg, radix scrophulariae 300kg, Radix Glycyrrhizae 100kg.
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；Add 6 times of water, impregnate 3 hours, decocts 3 times, 2 hours every time, merge decoction liquor, filtration, merging filtrate；It is cooled to room temperature, adds
Alcohol is to alcohol content up to 55%, and cold 48 hours heavy, filtration, decompression filtrate recycling ethanol is condensed into medicinal extract, spare；
(2) preparation process: the Sucralose of addition medicinal extract weight 0.5% and the dextrin of medicinal extract weight 40%, spraying granulation,
Packing.
Embodiment 6: the preparation of oral solution
Prescription:
Radix scutellariae 315kg, catechu 200kg, Fructus Forsythiae 315kg, campanulaceae 60kg, radix polygonati officinalis 80kg, Radix Ophiopogonis 160kg, glutinous rehmannia 180kg,
Radix scrophulariae 260kg, Radix Glycyrrhizae 60kg
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；The distilled water that 9 times of amounts are added for the first time boils 4 hours after impregnating 5 hours, extracts；Second of addition, 7 times of amount distilled water,
It boils 2 hours, extracts；The distilled water of 5 times of amounts is added in third time, and heating is boiled 1.5 hours, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 115 DEG C of pressure sterilizings 25
Minute, it dispenses to get oral liquid.
Embodiment 7: the preparation of oral solution
Prescription:
Radix scutellariae 300kg, catechu 180kg, Fructus Forsythiae 300kg, campanulaceae 50kg, radix polygonati officinalis 70kg, Radix Ophiopogonis 150kg, glutinous rehmannia 150kg,
Radix scrophulariae 250kg, Radix Glycyrrhizae 50kg.
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；The distilled water that 9 times of amounts are added for the first time boils 4 hours after impregnating 5 hours, extracts；Second of addition, 7 times of amount distilled water,
It boils 2 hours, extracts；The distilled water of 5 times of amounts is added in third time, and heating is boiled 1.5 hours, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 115 DEG C of pressure sterilizings 25
Minute, it dispenses to get oral liquid.
Embodiment 8: the preparation of oral solution
Prescription:
Radix scutellariae 330kg, catechu 250kg, Fructus Forsythiae 330kg, campanulaceae 70kg, radix polygonati officinalis 100kg, Radix Ophiopogonis 200kg, glutinous rehmannia 200kg,
Radix scrophulariae 280kg, Radix Glycyrrhizae 70kg.
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；The distilled water that 9 times of amounts are added for the first time boils 4 hours after impregnating 5 hours, extracts；Second of addition, 7 times of amount distilled water,
It boils 2 hours, extracts；The distilled water of 5 times of amounts is added in third time, and heating is boiled 1.5 hours, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 115 DEG C of pressure sterilizings 25
Minute, it dispenses to get oral liquid.
Embodiment 9: the preparation of oral solution
Prescription:
Radix scutellariae 250kg, catechu 150kg, Fructus Forsythiae 250kg, campanulaceae 30kg, radix polygonati officinalis 50kg, Radix Ophiopogonis 100kg, glutinous rehmannia 130kg,
Radix scrophulariae 200kg, Radix Glycyrrhizae 30kg.
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；The distilled water that 8 times of amounts are added for the first time boils 3 hours after impregnating 6 hours, extracts；Second of addition, 8 times of amount distilled water,
It boils 3 hours, extracts；The distilled water of 6 times of amounts is added in third time, and heating is boiled 1 hour, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 120 DEG C of pressure sterilizings 15
Minute, it dispenses to get oral liquid.
Embodiment 10: the preparation of oral solution
Prescription:
Radix scutellariae 350kg, catechu 300kg, Fructus Forsythiae 350kg, campanulaceae 100kg, radix polygonati officinalis 120kg, Radix Ophiopogonis 250kg, glutinous rehmannia
250kg, radix scrophulariae 300kg, Radix Glycyrrhizae 100kg.
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；The distilled water that 10 times of amounts are added for the first time boils 5 hours after impregnating 4 hours, extracts；Second of addition, 6 times of amount distilled water,
It boils 1 hour, extracts；The distilled water of 4 times of amounts is added in third time, and heating is boiled 2 hours, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 110 DEG C of pressure sterilizings 35
Minute, it dispenses to get oral liquid.
Embodiment 11: the preparation of tablet
Prescription:
Radix scutellariae 315kg, catechu 200kg, Fructus Forsythiae 315kg, campanulaceae 60kg, radix polygonati officinalis 80kg, Radix Ophiopogonis 160kg, glutinous rehmannia 180kg,
Radix scrophulariae 260kg, Radix Glycyrrhizae 60kg
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；It decocting 2 times, the steam pressure of extractor is controlled in decoction process in 0.1-0.2Mpa, temperature range is 98-105 DEG C, first
Secondary plus 10 times of amount water impregnate 3 hours, decoct 4 hours；For the second time plus 8 times of amount boiling water decoct 2 hours, merge decoction liquor, filter,
Merging filtrate is cooled to room temperature, and adds alcohol to alcohol content up to 38%, cold 28 hours heavy, filtration, decompression filtrate recycling ethanol is concentrated
The medicinal extract for being 1.15-1.25 at density, it is spare；
(2) preparation process: the Sucralose of addition medicinal extract weight 0.3% and the dextrin of medicinal extract weight 45%, spraying granulation,
Suitable auxiliary material, tabletting is added.
Embodiment 12: the preparation of capsule
Prescription:
Radix scutellariae 315kg, catechu 200kg, Fructus Forsythiae 315kg, campanulaceae 60kg, radix polygonati officinalis 80kg, Radix Ophiopogonis 160kg, glutinous rehmannia 180kg,
Radix scrophulariae 260kg, Radix Glycyrrhizae 60kg
Preparation process:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, radix scrophulariae, the licorice powder of recipe quantity extraction process: are taken
It is broken；It decocting 2 times, the steam pressure of extractor is controlled in decoction process in 0.1-0.2Mpa, temperature range is 98-105 DEG C, first
Secondary plus 10 times of amount water impregnate 3 hours, decoct 4 hours；For the second time plus 8 times of amount boiling water decoct 2 hours, merge decoction liquor, filter,
Merging filtrate is cooled to room temperature, and adds alcohol to alcohol content up to 38%, cold 28 hours heavy, filtration, decompression filtrate recycling ethanol is concentrated
The medicinal extract for being 1.15-1.25 at density, it is spare；
(2) preparation process: the Sucralose of addition medicinal extract weight 0.3% and the dextrin of medicinal extract weight 45%, spraying granulation,
Dispense capsule.
Experimental example:
Experimental example 1: the influence of pharmaceutical composition paraxylene induced mice auricle edema of the present invention
Take weight 18-22g male NIH mouse 140, be randomly divided into 14 groups, blank control group, aspirin group,
Embodiment 1-12 group, every group 10, wherein blank control group stomach-filling distilled water, other each groups are tested by 1 stomach-filling of table
Drug, one time a day, after continuous 6d, last dose 1h, two sides applies 0.05mL caused by dimethylbenzene xylene and swells before and after the left ear of every mouse, auris dextra
It does not apply and compares, after 30min, put to death animal, cut left and right ear, lay round ear at same position respectively with 9mm diameter punch
Piece weighs with scale, and using left and right ear difference as swelling, data are handled through independent samples t-test, the results are shown in Table 1.
Table 1: anti-inflammation test result (n=10,)
Note: compared with blank control group:ΔP > 0.05,ΔΔP < 0.05,ΔΔΔP < 0.01.
1 test result of table shows that embodiment 1-10 has an extremely significant sex differernce compared with blank group, experimental example 11,12 with
Blank group relatively has significant difference.Especially embodiment 1 and embodiment 6, paraxylene induced mice auricle edema it is anti-inflammatory
Function and effect are better than aspirin.
Experimental example 2: the influence that pharmaceutical composition of the present invention coughs to concentrated ammonia liquor induced mice
Weight 18-22g NIH mouse 140 are taken, half male and half female is randomly divided into 14 groups by weight and gender, blank control
Group, anxious branch cough syrup group, embodiment 1-12 group, every group 10, wherein blank control group stomach-filling distilled water, other each groups press table
Mouse after continuous 3d, last dose 1h, is put into the bell jar of volume 4L by 2 stomach-filling test medicines respectively one time a day, with
53.2KPa constant pressure uniformly sprays into 27% ammonium hydroxide, 5 seconds stimulation mouse and causes cough (draw the abdomen, face upward head, magnify mouth as cough instruction), observation
The cough latent period of mouse and the cough number in 2min, data the results are shown in Table 2 through independent samples t-test.
Table 2: cough-relieving test result (n=10,)
Note: compared with blank control group:ΔP > 0.05,ΔΔP < 0.05,ΔΔΔP < 0.01.
2 test result of table shows that embodiment 1-10 has an extremely significant sex differernce compared with blank group, experimental example 11,12 with
Blank group relatively has significant difference.Especially embodiment 1 and embodiment 6, hence it is evident that shorten to the cough time of concentrated ammonia liquor induced mice
Number, and cough suppressing effect average level is better than anxious branch cough syrup group.
Experimental example 3: the clinical research of acpuei pharyngitis caused by medicine composite for curing lung heat of the present invention
2 months~in March, 2018 in 2017, we entrust Fei County Second Academy collection volunteer to participate in research, using medicine of the present invention
Acpuei pharyngitis 300, significant in efficacy caused by compositions preparation for treating lung heat.
Clinical data:
350 acpuei pharyngitis patients are screened, following diagnostic criteria is met:
Symptom: pharyngalgia (exacerbation when swallowing food), pharyngeal dryness and heat, fever with chilliness, headache, cough and expectoration, whole body acid
Pain, dysphonia.
Sign: pharyngeal mucosa is congested, outstanding heap soil or fertilizer over and around the roots is vertical, soft palate is red and swollen.
14 groups are randomly divided by medical sequence, every group 25, wherein male 15, female 10,18~70 one full year of life of age is averaged
40 one full year of life treated with 5 days as one therapeutic course.During treatment in addition to trial drug or control drug, other drugs, such as body temperature are not had to
More than 39 DEG C, give Physical temperature-lowering.Over the course for the treatment of exacerbation of symptoms, there are purulence tears, phlegm person, as invalid.
Criterion of therapeutical effect:
Recovery from illness: symptom mitigates within medication 3 days, and clinical symptoms and sign disappear within 5 days.
Effective: symptom, sign are obviously improved within medication 5 days.
Effective: symptom, sign take a favorable turn within medication 5 days.
12 groups of test group, respectively using drug prepared by embodiment 1-12；
2 groups of control group, control group 1 uses " Qinghouyan Granules ", control group 2 to use " Qinghouyan Mixture ".
It the results are shown in Table 3:
| Drug | Recovery from illness example | Effective example | Effective example | Total effective rate |
| Embodiment 1 | 15 | 6 | 4 | 100% |
| Embodiment 2 | 15 | 5 | 4 | 96% |
| Embodiment 3 | 14 | 6 | 4 | 96% |
| Embodiment 4 | 13 | 6 | 6 | 92% |
| Embodiment 5 | 13 | 6 | 4 | 92% |
| Embodiment 6 | 15 | 7 | 3 | 100% |
| Embodiment 7 | 15 | 5 | 4 | 96% |
| Embodiment 8 | 14 | 5 | 4 | 92% |
| Embodiment 9 | 13 | 5 | 6 | 96% |
| Embodiment 10 | 12 | 7 | 4 | 92% |
| Embodiment 11 | 13 | 6 | 5 | 96% |
| Embodiment 12 | 14 | 5 | 5 | 96% |
| Control group 1 | 7 | 6 | 3 | 64% |
| Control group 2 | 6 | 5 | 6 | 68% |
It is aobvious that the above statistical result illustrates that the drug of 1-12 of embodiment of the present invention preparation has acpuei pharyngitis caused by lung heat
Write curative effect.The curative effect of medication of control group is relatively poor, and within medication 5 days, and recovery from illness example is considerably less than each test group.
Experimental example 4: Study on extraction test of the present invention:
Inventor passes through a large number of experiments, it is found that amount of water and paste-forming rate relationship are very big in extraction process, now pass through experimental example
It is illustrated.
In order to be compared, in addition to amount of water is changed, other controls are as follows:
Radix scutellariae 315g, catechu 200g, Fructus Forsythiae 315g, campanulaceae 60g, radix polygonati officinalis 80g, Radix Ophiopogonis 160g, glutinous rehmannia 180g, radix scrophulariae
260g, Radix Glycyrrhizae 60g (feed intake 1630g altogether)
1, it decocts 2 times, the steam pressure of extractor is controlled in decoction process in 0.1-0.2Mpa, temperature range 98-105
℃；
2, it impregnates 3 hours, decocts 4 hours for the first time plus after water；Second plus boiling water decoction 2 hours, merge decoction liquor, filter
It crosses, merging filtrate is cooled to room temperature；
3, plus alcohol is to alcohol content up to 38%, and cold 28 hours heavy, filtration, decompression filtrate recycling ethanol, being condensed into density is
1.15-1.25 medicinal extract.
Result of study shows first time amount of water at 6-10 times, and paste-forming rate is apparently higher than 4 times, 12 times of water, it is seen that for the first time
Amount of water control is relatively good between 6-10 times.First time amount of water is controlled at 6 times, 8 times or 10 times, and second of amount of water exists
Paste-forming rate between 6-10 times is apparently higher than 4 times or 12 times, it is seen then that second of amount of water control is more preferable at 6-10 times, especially
When adding 10 times of water, second plus 8 times of water for the first time, paste-forming rate highest.
Amount of water is shown in Table 4 to the influence test result for extracting paste-forming rate:
4 amount of water of table is to the influence test result for extracting paste-forming rate
Claims (10)
1. a kind of Chinese medicine composition for treating acpuei pharyngitis, which is characterized in that the Chinese medicine composition prepared by following medicinal material and
At: radix scutellariae 250-350 parts by weight, catechu 150-300 parts by weight, Fructus Forsythiae 250-350 parts by weight, campanulaceae 30-100 parts by weight, jade
Bamboo 50-120 parts by weight, Radix Ophiopogonis 100-250 parts by weight, glutinous rehmannia 130-250 parts by weight, radix scrophulariae 200-300 parts by weight, Radix Glycyrrhizae 30-
100 parts by weight.
2. Chinese medicine composition as described in claim 1, which is characterized in that the Chinese medicine composition prepared by following medicinal material and
At: radix scutellariae 300-330 parts by weight, catechu 180-250g parts by weight, Fructus Forsythiae 300-330 parts by weight, campanulaceae 50-70 parts by weight, jade
Bamboo 70-100 parts by weight, Radix Ophiopogonis 150-200 parts by weight, glutinous rehmannia 150-200 parts by weight, radix scrophulariae 250-280 parts by weight, Radix Glycyrrhizae 50-
70 parts by weight.
3. Chinese medicine composition as claimed in claim 2, which is characterized in that the Chinese medicine composition prepared by following medicinal material and
At: 315 parts by weight of radix scutellariae, 200 parts by weight of catechu, 315 parts by weight of Fructus Forsythiae, 60 parts by weight of campanulaceae, 80 parts by weight of radix polygonati officinalis, Radix Ophiopogonis
160 parts by weight, 180 parts by weight of glutinous rehmannia, 260 parts by weight of radix scrophulariae, 60 parts by weight of Radix Glycyrrhizae.
4. the Chinese medicine composition as described in claim 1-3, which is characterized in that the Chinese medicine composition can be prepared into oral solid
Body preparation or oral liquid.
5. Chinese medicine composition as claimed in claim 4, which is characterized in that the oral solid formulation be granule, capsule,
Tablet, preferably granule.
6. Chinese medicine composition as claimed in claim 5, which is characterized in that the oral liquid be oral solution or mixture,
It is preferred that oral solution.
7. Chinese medicine composition as claimed in claim 4, which is characterized in that when the preparation is oral solid formulation, system
Standby technique is as follows:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, the radix scrophulariae, Radix Glycyrrhizae crushing of recipe quantity extraction process: are taken；Add
6-10 times of water impregnates 1-3 hours, decocts 1-3 times, 2-4 hours each, merges decoction liquor, filtration, merging filtrate；It is cooled to room
Temperature adds alcohol to alcohol content up to 35%-55%, and cold 12-48 hours heavy, filtration, decompression filtrate recycling ethanol is condensed into medicinal extract, standby
With；
(2) preparation process: being added the Sucralose of medicinal extract weight 0.1-0.5% and the dextrin of medicinal extract weight 40-50%, spraying to make
Grain, routinely preparation process is prepared into oral solid formulation.
8. Chinese medicine composition as claimed in claim 7, which is characterized in that when the preparation is oral solid formulation, system
Standby technique is as follows:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, the radix scrophulariae, Radix Glycyrrhizae crushing of recipe quantity extraction process: are taken；It decocts
It boils 2 times, the steam pressure of extractor is controlled in decoction process in 0.1-0.2Mpa, temperature range is 98-105 DEG C, is added for the first time
10 times of amount water impregnate 3 hours, decoct 4 hours；For the second time plus 8 times of amount boiling water decoct 2 hours, merge decoction liquor, filter, merging
Filtrate is cooled to room temperature, and adds alcohol to alcohol content up to 38%, cold 28 hours heavy, filtration, decompression filtrate recycling ethanol is condensed into close
Degree is the medicinal extract of 1.15-1.25, spare；
(2) Sucralose of medicinal extract weight 0.3% and the dextrin of medicinal extract weight 45%, spraying granulation, by normal preparation process: is added
Rule preparation process is prepared into oral solid formulation.
9. Chinese medicine composition as claimed in claim 4, which is characterized in that when the preparation is oral liquid, system
Standby technique is as follows:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, the radix scrophulariae, Radix Glycyrrhizae crushing of recipe quantity extraction process: are taken；The
The 8-10 times of distilled water measured once is added, after impregnating 4-6 hours, boils 3-5 hours, extracts；Distillation is measured in second of 6-8 times of addition
Water boils 1-3 hours, extracts；The 4-6 times of distilled water measured is added in third time, and heating is boiled 1-2 hours, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 110-120 DEG C of pressure sterilizing
It 15-35 minutes, packs to get oral liquid.
10. Chinese medicine composition as claimed in claim 9, which is characterized in that when the preparation is oral liquid, system
Standby technique is as follows:
(1) radix scutellariae, catechu, Fructus Forsythiae, campanulaceae, radix polygonati officinalis, Radix Ophiopogonis, glutinous rehmannia, the radix scrophulariae, Radix Glycyrrhizae crushing of recipe quantity extraction process: are taken；The
The primary distilled water that 9 times of amounts are added boils 4 hours after impregnating 5 hours, extracts；Second of addition, 7 times of amount distilled water, boil 2
Hour, it extracts；The distilled water of 5 times of amounts is added in third time, and heating is boiled 1.5 hours, extracts；
(2) preparation process: merging extracting solution three times, and filtering obtains filtrate, seals up for safekeeping filtrate is filling, 115 DEG C of pressure sterilizings 25 divide
Clock is packed to get oral liquid.
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| CN116139220A (en) * | 2022-12-06 | 2023-05-23 | 沈阳药科大学 | Health product with lung protection function and preparation method and application thereof |
| CN116234561A (en) * | 2020-09-18 | 2023-06-06 | 天津中医药大学 | Pharmaceutical composition for preventing and treating respiratory diseases in winter |
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