CN104840566A - Throat lozenge used for treating acute pharyngitis as well as preparation method and application thereof - Google Patents
Throat lozenge used for treating acute pharyngitis as well as preparation method and application thereof Download PDFInfo
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- CN104840566A CN104840566A CN201510280465.1A CN201510280465A CN104840566A CN 104840566 A CN104840566 A CN 104840566A CN 201510280465 A CN201510280465 A CN 201510280465A CN 104840566 A CN104840566 A CN 104840566A
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Abstract
The invention belongs to the field of traditional Chinese medicines and provides a throat lozenge. The aim of treating acute pharyngitis is achieved by clearing away heat and toxic materials and removing stasis and relieving sore throat. In order to achieve the aim, active ingredients contained in the throat lozenge are prepared from the following raw materials in parts by weight: 20 parts of all-grass of Nepal knotweed, 15 parts of herb of hard melandrium, 18 parts of root of threeangleabranch clovershrub, 20 parts of auricled hedyotis herb and 14 parts of anaphalis bulleyana. A corresponding preparation method is adopted. The throat lozenge has the function of treating acute pharyngitis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of be used for the treatment of acute pharyngitis throat lozenge and method for making and application.
Background technology
Acute pharyngitis is pharyngeal mucous membrane, and under involving mucosa and adenoid acute inflammation, be often secondary to acute rhinitis or acute draw tonsil after or be the part of upper respiratory tract infection.Also be often the topical manifestations of general disease or the prodrome for acute infectious disease.This disease can occur separately, is also often secondary to acute rhinitis or tonsillitis.Primary disease is common in the friendship in autumn, winter and winter, spring.Onset is comparatively anxious, from the beginning of time pharyngeal drying, scorching hot.Continued pain, and when swallowing saliva, pharyngalgia is often than more obvious during feed.Conventional antiviral agents (as moroxydine, amantadine etc.) and the treatment such as antibiotic or sulfonamides, side effect is large, and patient is difficult to tolerance, and Chinese medicine also has lysozyme buccal tablet, tabella domipheni laryngiticae, iodine lozenge or Mint throat lozenge etc., and effect is all not obvious.The throat lozenge of a kind of determined curative effect of market in urgent need.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of throat lozenge for the treatment of acute pharyngitis.
Technical scheme: the object of the invention is by following scheme realize:
Be used for the treatment of a throat lozenge for acute pharyngitis, the active component contained by it is prepared from by following raw materials in part by weight proportioning: Herba Polygoni nepalensis 20 parts, Herba melandrii firmi 15 parts, greatly deliver 18 parts, Auricled Hedyotis Herb 20 parts, wild peppery cigarette 14 parts.
The described throat lozenge being used for the treatment of acute pharyngitis, preparation method is: get above-mentioned medical material and merge, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add Sucrose Content, tabletting.
The application of the described throat lozenge being used for the treatment of acute pharyngitis in preparation treatment acute pharyngitis medicine.
Herba Polygoni nepalensis is the herb of polygonaceae plant Nepal knotweed.Latin name: Polygonum nepalense Meissn., heat-clearing and toxic substances removing; Eliminating dampness and dredging channels.Main laryngopharynx swelling and pain; Conjunctival congestion; Gingival swelling and pain; Dysentery; Rheumatic arthralgia.
Herba melandrii firmi is the herb of the sturdy Herba Melandrii Aprici of pinkwort.Latin name: Silene firma Sieb.Et Zucc., gathers during 8 ~ JIUYUE seed maturity, dries.Heat-clearing and toxic substances removing; Diuresis; Regulating menstruation.Cure mainly laryngopharynx swelling and pain; (ear booth) ear comes to a head; Dysuria.
Deliver greatly as Dou Ke Jing tip platymiscium Rhizoma Sparganii Zhi Jing tip Campylotropis trigonoclada (Franch.) A.K.Schindl., be used as medicine with root and Herb.Xia Qiucai, dries or using fresh herb.Relieving the exterior syndrome by diaphoresis, clearing away heat-damp and promoting diuresis.For cold, fever, rhinitis, enteritis, dysentery, cystitis, nephritis, rheumatic arthritis; Traumatic injury is controlled in external.
Auricled Hedyotis Herb is the herb of Maguireothamnus speciosus Auricled Hedyotis Herb.Classification system is HerbaHedyotidisAnriculariae, heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.For cold, fever, cough due to lung-heat, laryngalgia, acute conjunctivitis, enteritis, dysentery; Venom is controlled in external, traumatic injury, carbuncle pyogenic infections from tumour or sore, mastitis, eczema.
Wild peppery cigarette is fragrant blue or green Anaphalis bulleyana (J.E.Jeffr.) Chang of Compositae anaphalis plant adhesive hair, with all herbal medicine.The whole year can adopt, and cleans chopping, dries.Clearing away heat-damp and promoting diuresis, cough-relieving, preventing the attack (or recurrence) of malaria.For flu, tracheitis, tonsillitis, pertussis, acute gastroenteritis, cystitis, urethritis, infantile malnutrition, malaria.
Beneficial effect: from theory of Chinese medical science, Herba Polygoni nepalensis, Herba melandrii firmi heat-clearing and toxic substances removing in we; Eliminating dampness and dredging channels is monarch drug, delivers greatly, Auricled Hedyotis Herb relieving the exterior syndrome by diaphoresis, and clearing away heat-damp and promoting diuresis is ministerial drug, wild peppery cigarette cough-relieving, and preventing the attack (or recurrence) of malaria is adjuvant, and all medicines are harmonious, and plays heat-clearing and toxic substances removing, the effect of eliminating stagnation sore-throat relieving altogether, for acute pharyngitis.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: get Herba Polygoni nepalensis 20g, Herba melandrii firmi 15g, deliver 18g greatly, Auricled Hedyotis Herb 20g, wild peppery cigarette 14g medical material merges, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add cane sugar powder 20g, tabletting.
Embodiment 2: clinical study results
2.1 clinical medicines: throat lozenge of the present invention, prepare by the method for above-described embodiment 1, specification: 2g/ sheet.
The routine patient of 2.2 clinical observation 50, man 26 example, female 24 example, age 38-62 year, acute pharyngitis, each containing 2, the morning, noon and afternoon are respectively once.
2.3 diagnostic criterias:
2.3.1 medical history can have suffer from cold, the inducement such as the stimulation of tired, excessive, the various physics and chemistry of tobacco and wine.
2.3.2 symptom
(1) onset is more anxious.
(2) pharyngeal drying, scorching hot, pain or odynophagia.
(3) heating, fear of cold, inappetence, extremities aching pain, these symptoms occur in small number of patients, and most of patients performance and not obvious.
2.3.3 check
(1) pharyngeal mucosa is congested, and color is scarlet.
(2) swallow rear wall lymph follicle and lateral pharyngeal band redness, small number of patients local has yellow-white secretions to adhere to.
(3) uvula, soft palate edema.
(4) throat swab is cultivated can pathogenic bacterium or feminine gender, can do the drug sensitive test of new drug simultaneously.
2.3.4 possess above-mentioned part or all of symptom, and have more than one or one to check finding positive sign, after the following disease of eliminating, can diagnosis be made.
(1) measles; Early stage Oral Health Suryey has the symptom such as measles and eye conjunctivitis.
(2) scarlet fever: have high heat, pharyngeal peony congested, strawberry-like tongue and typical erythra.
(3) influenza: have nasal obstruction watery nasal discharge, generates heat heavier.
(4) infectious monocytosis: be more common in children's, has heating, ridicules pain.Hemogram monocytosis to 40% ~ 80%, serum heterophil agglutination reaction is positive, and tire more than 1:64.
(5) agranulocytosis: General Symptoms is heavier, leukocyte significantly reduces, thrombocytopenia.
(6) leukemic angina: pharyngalgia, pharynx mucosa is pale, swelling or have ulcer, and the enlargement of lymph node is hard, and hemogram, bone marrow smear are shown in that leucoblast increases.
2.5 Outcome measure:
Curative effect is judged with reference to " new Chinese medicine guideline of clinical investigations (trying) " (version in 2002) acute pharyngitis criterion of therapeutical effect.Clinical recovery: within medication 3d, symptom alleviates, in 5 days, clinical symptoms and sign disappear; Effective: in medication 5 days, symptom, sign are obviously improved; Effective: in medication 5 days, symptom and sign make moderate progress: invalid: in medication 5 days, symptom and sign are not improved.The results are shown in Table 1
Table 1. the present invention is to the observation of curative effect of acute pharyngitis patient
This throat lozenge, through clinical practice, has easing pain and diminishing inflammation, heat-clearing and toxic substances removing, eliminating stagnation sore-throat relieving, the effect for the treatment of acute pharyngitis.Medicine of the present invention as can be seen from Table 1, in 50 examples, total effective rate is 98%, has no adverse reaction in using.
Claims (3)
1. be used for the treatment of a throat lozenge for acute pharyngitis, it is characterized in that, the active component contained by it is prepared from by following raw materials in part by weight proportioning: Herba Polygoni nepalensis 20 parts, Herba melandrii firmi 15 parts, greatly deliver 18 parts, Auricled Hedyotis Herb 20 parts, wild peppery cigarette 14 parts.
2. be used for the treatment of the throat lozenge of acute pharyngitis as claimed in claim 1, it is characterized in that, preparation method is: get above-mentioned medical material and merge, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add cane sugar powder, tabletting.
3. be used for the treatment of the application of throat lozenge in treatment acute pharyngitis medicine of acute pharyngitis as claimed in claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109316551A (en) * | 2018-11-20 | 2019-02-12 | 山东罗欣乐康制药有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis |
Citations (4)
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| CN101069703A (en) * | 2006-05-11 | 2007-11-14 | 凌沛学 | Medicine for treating acute, chronic pharyngitis, acute, chronic tonsillitis and preparing method |
| CN101380393A (en) * | 2008-04-30 | 2009-03-11 | 王士学 | Ointment for treating pharyngitis and preparation method thereof |
| CN101411782A (en) * | 2008-11-11 | 2009-04-22 | 南京同仁堂药业有限责任公司 | Pharmaceutical composition for treating acute pharyngitis and preparation method thereof |
| CN101695512A (en) * | 2009-10-30 | 2010-04-21 | 洛阳新春都生物制药有限公司 | Banlangen buccal tablet and preparation method thereof |
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- 2015-05-28 CN CN201510280465.1A patent/CN104840566A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101069703A (en) * | 2006-05-11 | 2007-11-14 | 凌沛学 | Medicine for treating acute, chronic pharyngitis, acute, chronic tonsillitis and preparing method |
| CN101380393A (en) * | 2008-04-30 | 2009-03-11 | 王士学 | Ointment for treating pharyngitis and preparation method thereof |
| CN101411782A (en) * | 2008-11-11 | 2009-04-22 | 南京同仁堂药业有限责任公司 | Pharmaceutical composition for treating acute pharyngitis and preparation method thereof |
| CN101695512A (en) * | 2009-10-30 | 2010-04-21 | 洛阳新春都生物制药有限公司 | Banlangen buccal tablet and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109316551A (en) * | 2018-11-20 | 2019-02-12 | 山东罗欣乐康制药有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating acpuei pharyngitis |
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Application publication date: 20150819 |