CN104000962A

CN104000962A - Lozenge for curing acute pharyngitis and preparation method and application thereof

Info

Publication number: CN104000962A
Application number: CN201410272727.5A
Authority: CN
Inventors: 徐艳
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-18
Filing date: 2014-06-18
Publication date: 2014-08-27

Abstract

The invention provides a lozenge. The purpose of curing acute pharyngitis is achieved by easing pains and diminishing inflammation, clearing away heat and toxic materials, removing stasis and relieving sore throat. In order to achieve the purpose, according to the technical scheme, the active ingredients contained in the lozenge are composed of, by weight, 5-15 parts of nocturnal grass, 8-12 parts of climbing oldenlandia, 8-12 parts of eriosema himalaicum ohashi, 8-12 parts of Japanese polygala, 2-4 parts of pyrola and 5-8 parts of liquorice. A corresponding preparation method is used, and the lozenge has the function of curing the acute pharyngitis.

Description

A kind of buccal tablet for the treatment of acute pharyngitis and its preparation method and application

Technical field

The present invention relates to Chinese medicine preparation technical field, be specifically related to a kind of buccal tablet and method for making and application for the treatment of acute pharyngitis.

Background technology

Acute pharyngitis is the acute inflammation of pharyngeal mucosa and mucosa undertissue.Pharynx lymphoid tissue is often involved.Inflammation can be limited in early days, with disease progression, often can relate to whole pharyngeal cavity.Primary disease is with the autumn and winter and at the end of winter and the beginning of spring more common.The treatments such as conventional antiviral agents (as moroxydine, amantadine etc.) and antibiotic or sulfonamides, side effect is large, and patient is difficult to tolerance, and Chinese medicine also has lysozyme buccal tablet, tabella domipheni laryngiticae, iodine lozenge or Herba Menthae lozenge etc., and effect is all not obvious.The buccal tablet of a kind of determined curative effect of market in urgent need.

Summary of the invention

Goal of the invention: in order to address the above problem, the object of the present invention is to provide a kind of buccal tablet for the treatment of acute pharyngitis.

Technical scheme: the object of the invention is to realize by following scheme:

Treat a buccal tablet for acute pharyngitis, its contained active component is prepared from by following raw materials in part by weight proportioning: the careless 5-15 part of going out walking in the night, Os Equi save 8-12 part, arrange red careless 8-12 part, Herba Polygalae Japonicae 8-12 part, Herba Pyrolae 2-4 part, Radix Glycyrrhizae 5-8 part.

The buccal tablet of described treatment acute pharyngitis, its contained active component is prepared from by following raw materials in part by weight proportioning: 10 parts of the grass of going out walking in the night, 10 parts, Os Equi joint, arrange red careless 10 parts, 10 parts of Herba Polygalae Japonicae, 3 parts of Herba Pyrolaes, 6 parts, Radix Glycyrrhizae.

The buccal tablet of described treatment acute pharyngitis, preparation method is that the medical material of getting recipe quantity merges, and through water extract-alcohol precipitation, concentrated, spraying is dry, and with sucrose, pelletizing press sheet, becomes buccal tablet.

The application of the buccal tablet of described treatment acute pharyngitis in the medicine of preparation treatment acute pharyngitis.Beneficial effect:

From theory of Chinese medical science, the grass of going out walking in the night in we induces sweat and brings down a fever, anti-inflammatory analgetic, Herba Pyrolae nourishing the lung to arrest cough, anti-inflammatory analgetic, is monarch drug altogether, Os Equi joint nourishing YIN and moistening the lung, heat clearing awayization is rotten, arranges red careless reducing swelling and alleviating pain, Herba Polygalae Japonicae heat-clearing and toxic substances removing, opens breast eliminating stagnation, is minister, Radix Glycyrrhizae is adjuvant drug, all medicines are harmonious, and play altogether easing pain and diminishing inflammation, heat-clearing and toxic substances removing, the effect of eliminating stagnation sore-throat relieving, for acute pharyngitis.Formulation is reasonable, and compatibility is rigorous.Consist of Chinese crude drug, have no side effect, low price.

The specific embodiment

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as to the scope of the above-mentioned theme of the present invention only limits to following example, all technology realizing based on foregoing of the present invention all belong to scope of the present invention.

One, Preparation Example 1:

Get the careless 10g that goes out walking in the night, Os Equi joint 10g, arrange red careless 10g, Herba Polygalae Japonicae 10g, Herba Pyrolae 3g, Radix Glycyrrhizae 6g medical material merges, decoct with water twice, amount of water is 10 times of amounts of medical material weight, decoct 2h, collecting decoction, while being concentrated into 65 ℃, relative density is 1.10, adding ethanol makes to reach 65% containing the percent by volume of alcohol amount, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.20 and reclaims ethanol, concentrated solution spraying is dry, spraying drying condition is: inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 70 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add sucrose, tabletting is made buccal tablet.

Two, clinical research result

2.1 clinical medicines: buccal tablet of the present invention, specification: 1g/ sheet, by the preparation method preparation of above-described embodiment 1.

The routine patient of 2.2 clinical observation 50, male 28 examples, female's 22 examples, age 27-66 year, acute pharyngitis, 2 of each pharyngeal buccal, the morning, noon and afternoon each once.

2.3 diagnostic criterias:

2.3.1 medical history can have suffer from cold, tired, tobacco and wine are excessive, the inducements such as stimulation of various physics and chemistries.

2.3.2 symptom

(1) onset is more anxious.

(2) pharyngeal dry, scorching hot, pain or odynophagia.

(3) heating, fear of cold, inappetence, extremities aching pain, these symptoms occur in small number of patients, and in most of patients performance not obvious.

2.3.3 check

(1) pharyngeal mucosa is congested, and color is scarlet.

(2) pharynx rear wall lymph follicle and lateral pharyngeal band are red and swollen, and small number of patients part has yellow-white secretions to adhere to.

(3) uvula, soft palate edema.

(4) throat swab is cultivated can pathogenic bacterium or feminine gender, can do the drug sensitive test of new drug simultaneously.

2.3.4 possess above-mentioned part or all of symptom, and have one or an above finding positive sign that checks, after getting rid of following disease, can make diagnosis.

(1) measles; Early stage oral cavity cheek mucosa has the symptoms such as measles and eye conjunctivitis.

(2) scarlet fever: have high heat, the hyperemia of pharyngeal peony, strawberry-like tongue and typical erythra.

(3) influenza: have nasal obstruction watery nasal discharge, generate heat heavier.

(4) infectious monocytosis: be more common in children's, have heating, ridicule pain.Hemogram monocytosis to 40%～80%, serum heterophil agglutination reaction is positive, tires more than 1:64.

(5) agranulocytosis: General Symptoms is heavier, leukocyte significantly reduces, thrombocytopenia.

(6) leukemia angina: pharyngalgia, pharynx mucosa is pale, swelling or have ulcer, the enlargement of lymph node is hard, and hemogram, bone marrow smear are shown in that leucoblast increases.

2.4 curative effect judgements:

With reference to < < new Chinese medicine guideline of clinical investigations (trying) > > (version in 2002) acute pharyngitis criterion of therapeutical effect judgement curative effect.Clinical recovery: medication 3d alleviates with interior symptom, in 5 days, clinical symptoms and sign disappear; Effective: in medication 5 days, symptom, sign are obviously improved; Effective: in medication 5 days, symptom and sign make moderate progress: invalid: in medication 5 days, symptom and sign are not improved.

The present invention, through clinical practice, has easing pain and diminishing inflammation, heat-clearing and toxic substances removing, eliminating stagnation sore-throat relieving, the effect for the treatment of acute pharyngitis, and in 50 examples, curing number is 34 examples, and good revolution is 14 examples, and invalid is 2 examples, and total effective rate is 96%, in use, has no adverse reaction.

Claims

1. a buccal tablet for the treatment of acute pharyngitis, it is characterized in that, its contained active component is prepared from by following raw materials in part by weight proportioning: the careless 5-15 part of going out walking in the night, Os Equi save 8-12 part, arrange red careless 8-12 part, Herba Polygalae Japonicae 8-12 part, Herba Pyrolae 2-4 part, Radix Glycyrrhizae 5-8 part.

2. treat as claimed in claim 1 the buccal tablet of acute pharyngitis, it is characterized in that, its contained active component is prepared from by following raw materials in part by weight proportioning: 10 parts of the grass of going out walking in the night, 10 parts, Os Equi joint, arrange red careless 10 parts, 10 parts of Herba Polygalae Japonicae, 3 parts of Herba Pyrolaes, 6 parts, Radix Glycyrrhizae.

3. treat as claimed in claim 1 the buccal tablet of acute pharyngitis, it is characterized in that, preparation method is that the medical material of getting recipe quantity merges, and through water extract-alcohol precipitation, concentrated, spraying is dry, and with sucrose, pelletizing press sheet, becomes buccal tablet.

4. the application of the buccal tablet for the treatment of as claimed in claim 1 acute pharyngitis in the medicine of preparation treatment acute pharyngitis.