CN105687557A - Herbal rhinitis ointment and production method of herbal rhinitis ointment - Google Patents
Herbal rhinitis ointment and production method of herbal rhinitis ointment Download PDFInfo
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- 206010039083 rhinitis Diseases 0.000 title claims abstract description 39
- 239000002674 ointment Substances 0.000 title claims abstract description 30
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 36
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 241001116389 Aloe Species 0.000 claims abstract description 13
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 13
- 241000628997 Flos Species 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 claims description 22
- 241000411851 herbal medicine Species 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- 239000006071 cream Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 239000000470 constituent Substances 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical group [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 206010039085 Rhinitis allergic Diseases 0.000 abstract description 6
- 206010039101 Rhinorrhoea Diseases 0.000 abstract description 6
- 201000010105 allergic rhinitis Diseases 0.000 abstract description 6
- 208000036071 Rhinorrhea Diseases 0.000 abstract description 5
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 210000003928 nasal cavity Anatomy 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 238000009423 ventilation Methods 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
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- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 1
- 206010041232 sneezing Diseases 0.000 abstract 1
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- 239000003814 drug Substances 0.000 description 25
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- 238000002360 preparation method Methods 0.000 description 6
- 201000009890 sinusitis Diseases 0.000 description 6
- 231100000252 nontoxic Toxicity 0.000 description 4
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- CNIIGCLFLJGOGP-UHFFFAOYSA-N 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Chemical compound C=1C=CC2=CC=CC=C2C=1CC1=NCCN1 CNIIGCLFLJGOGP-UHFFFAOYSA-N 0.000 description 2
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- 230000001139 anti-pruritic effect Effects 0.000 description 1
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- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
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- 229940126673 western medicines Drugs 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/534—Mentha (mint)
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- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention provides a herbal rhinitis ointment and a production method of the herbal rhinitis ointment. The herbal rhinitis ointment is prepared from the following effective raw materials in parts by weight: 10 to 20 parts of herba centipedae, 5 to 15 parts of aloe, 10 to 15 parts of radix sophorae flavescentis, 5 to 10 parts of cortex phellodendri, 8 to 10 parts of flos magnoliae, 5 to 10 parts of radix angelicae dahuricae and 2 to 5 parts of herba menthae. The herbal rhinitis ointment is further prepared from the following raw materials in parts by weight: 0.5 to 1 part of methyl p-hydroxy benzoate, 0.5 to 1 part of dimethyl sulfoxide, 5 to 10 parts of glycerol and 20 to 50 parts of water. The herbal rhinitis ointment is used for treating diseases including rhinitis, nasosinusitis, allergic rhinitis and the like, and has the effects of ventilation, inflammation diminishing, heat clearing and bacteria inhibition; the herbal rhinitis ointment has stable effect and no toxic or side effect, and has clinical practicability and pertinence. The ointment is convenient to use and is directly applied in a nasal cavity; the ointment is directly applied to an affected part and has no discomfort; occasionally, a patient has a sneezing feeling and a runny nose and the feelings disappear after one minute; the aim of basically recovering can be realized after the ointment is used for 7 to 15 days.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, particularly to a kind of book on Chinese herbal medicine rhinitis ointment and preparation method thereof。
Background technology
Rhinitis and nasal cavity inflammatory diseases, be the inflammation of the bronchia mucosal that virus, antibacterial, allergen, various physical and chemical factor and some systemic disease cause。The main pathological change of rhinitis is bronchia mucosal hyperemia, swelling, ooze out, hypertrophy, atrophy or necrosis etc.。The symptom of rhinitis often shows as nasal obstruction, sneeze, many tears, olfactory sensation decline, and majority are also often accompanied by headache, giddy, inappetence, the easily symptom such as tired, hypomnesis and insomnia。
When rhinitis is shown effect, the symptom such as nasal obstruction, continuous sneeze, watery nasal discharge and headache often has a strong impact on people and works normally and live。Owing to the cause of rhinitis is more complicated, patient, when using some western medicines, is taken stopgap measures and is not effected a permanent cure, and its therapeutic effect is all less desirable。And some Western medicine such as life-time service 0.5%～1% ephedrine can damage nasal mucosa ciliary structures at present, it is easier to add myxoidedema；Naphazoline, now has proven to it and can cause medicamentous rhinitis。
Chinese medicine is the rarity of China, if the sensible pharmacology of energy, uses it in the treatment of rhinitis, can take stopgap measures and effect a permanent cure, and have no side effect。Now also having the Chinese medicine preparation of some treatment rhinitis, but component is different, curative effect is different。
Summary of the invention
It is an object of the invention to provide a kind of book on Chinese herbal medicine rhinitis ointment and preparation method thereof, for treating the diseases such as rhinitis, sinusitis, allergic rhinitis, there is ventilation, antiinflammatory, relieve inflammation or internal heat, antibacterial effect, easy to use, have no sense of discomfort during use, use the purpose that can reach basic rehabilitation for 7 days-15 days。
For achieving the above object, the present invention realizes by the following technical solutions:
A kind of book on Chinese herbal medicine rhinitis ointment, constituent includes effective raw material of following composition by weight: Herba Centipedae: 10-20 part, Aloe: 5-15 part, Radix Sophorae Flavescentis: 10-15 part, Cortex Phellodendri: 5-10 part, Flos Magnoliae: 8-10 part, the Radix Angelicae Dahuricae: 5-10 part, Herba Menthae: 2-5 part。
Constituent also includes the raw material of following composition by weight: to the stupid methyl formate of hydroxyl: 0.5-1 part, dimethyl sulfoxide: 0.5-1 part, glycerol: 5-10 part, water: 20-50 part。
A kind of manufacture method of book on Chinese herbal medicine rhinitis ointment, including step in detail below:
1) take Aloe according to above-mentioned parts by weight proportioning, Radix Sophorae Flavescentis, Cortex Phellodendri, Flos Magnoliae, the Radix Angelicae Dahuricae, Herba Menthae are put in container, and the water heating adding above-mentioned parts by weight decocts, and heating-up temperature is 100 DEG C, and heat time heating time is 2 hours, then carries medicinal liquid and removes medicinal residues；
2) medicinal liquid of decoction is carried out again second distillation concentration extraction cream liquid；
3) add in condensed cream above-mentioned parts by weight to the stupid methyl formate of hydroxyl, dimethyl sulfoxide, glycerol, after being sufficiently stirred for mixing, stand, bottling seal preserve。
The effects such as in the present invention, Herba Centipedae has dispersing wind-cold, clearing the nasal passage, cough-relieving, detoxifies, antipruritic。Aloe has the effect of sterilization, antiinflammatory, removing toxic substances；In " property of medicine opinion " Aloe is on the books: head boil of malnutrition infant is killed in main nasal insufflation, except rhinocnesmus。Radix Sophorae Flavescentis: bitter, cold, nontoxic, drown and have the heeltap, relieve oedema or abdominal distension through diuresis or purgation, except carbuncle。Effect of Cortex Phellodendri: have nontoxic heat clearing and damp drying, eliminating fire and detoxication, brings down a fever except steaming。Flos Magnoliae: pungent, warm, nontoxic, cures mainly nasal sinusitis, nasal obstruction。The Radix Angelicae Dahuricae: be used as medicine with root, the function such as the dehumidifying that gets rid of illness, evacuation of pus granulation promoting, promoting blood circulation and stopping pain, cure mainly anemofrigid cold, headache, rhinitis, toothache。Effect of Herba Menthae: pungent, temperature, nontoxic, refresh oneself, except wind heat。The stupid methyl formate of hydroxyl be can be used for the anticorrosion of medicine。Skin is had extremely strong permeability as the solvent of medicine by dimethyl sulfoxide, contributes to medicine and permeates to human body, improves drug effect。The effect of glycerol: antioxidation, softening agent。
The using method of the present invention is: medicine is directly used in nasal cavity, and every day 2-3 time, by rear available clean water, the purpose that can reach basic rehabilitation in 7 days-15 days。
Compared with prior art, the invention has the beneficial effects as follows:
A kind of book on Chinese herbal medicine rhinitis ointment and preparation method thereof, is used for treating the diseases such as rhinitis, sinusitis, allergic rhinitis, has ventilation, antiinflammatory, relieves inflammation or internal heat, antibacterial effect, and this effect of drugs stably, has no side effect, has Clinical practicability, specific aim。The present invention is easy to use, arrives nasal cavity by directly upper for ointment, and medicine directly arrives sufferer place, has no sense of discomfort, occasionally has sneeze, rhinorrhea sense, can disappear after one minute, uses the purpose that can reach basic rehabilitation for 7 days-15 days。
Detailed description of the invention
A kind of book on Chinese herbal medicine rhinitis ointment, constituent includes effective raw material of following composition by weight: Herba Centipedae: 10-20 part, Aloe: 5-15 part, Radix Sophorae Flavescentis: 10-15 part, Cortex Phellodendri: 5-10 part, Flos Magnoliae: 8-10 part, the Radix Angelicae Dahuricae: 5-10 part, Herba Menthae: 2-5 part。
Constituent also includes the raw material of following composition by weight: to the stupid methyl formate of hydroxyl: 0.5-1 part, dimethyl sulfoxide: 0.5-1 part, glycerol: 5-10 part, water: 20-50 part。
A kind of manufacture method of book on Chinese herbal medicine rhinitis ointment, including step in detail below:
1) take Aloe according to above-mentioned parts by weight proportioning, Radix Sophorae Flavescentis, Cortex Phellodendri, Flos Magnoliae, the Radix Angelicae Dahuricae, Herba Menthae are put in container, and the water heating adding above-mentioned parts by weight decocts, and heating-up temperature is 100 DEG C, and heat time heating time is 2 hours, then carries medicinal liquid and removes medicinal residues；
2) medicinal liquid of decoction is carried out again second distillation concentration extraction cream liquid；
3) add in condensed cream above-mentioned parts by weight to the stupid methyl formate of hydroxyl, dimethyl sulfoxide, glycerol, after being sufficiently stirred for mixing, stand, bottling seal preserve。
Embodiment 1:
A kind of book on Chinese herbal medicine rhinitis ointment, the effective raw material being made up of following weight is made: Herba Centipedae: 10 parts, Aloe: 5 parts, Radix Sophorae Flavescentis: 10 parts, Cortex Phellodendri: 5 parts, Flos Magnoliae: 8 parts, the Radix Angelicae Dahuricae: 5 parts, Herba Menthae: 2 parts。
Also include the raw material of following weight composition: to the stupid methyl formate of hydroxyl: 0.5 part, dimethyl sulfoxide: 0.5 part, glycerol: 5 parts, water: 20 parts。
A kind of manufacture method of book on Chinese herbal medicine rhinitis ointment, including step in detail below:
1) take Aloe according to above-mentioned parts by weight proportioning, Radix Sophorae Flavescentis, Cortex Phellodendri, Flos Magnoliae, the Radix Angelicae Dahuricae, Herba Menthae are put in container, and the water heating adding above-mentioned parts by weight decocts, and heating-up temperature is 100 °, and heat time heating time is 2 hours, then carries medicinal liquid and removes medicinal residues；
2) pan-fried well-done medicinal liquid is carried out second distillation concentration extraction cream liquid again；
3) add in condensed cream above-mentioned parts by weight to the stupid methyl formate of hydroxyl, dimethyl sulfoxide, glycerol, after being sufficiently stirred for mixing, stand, bottling seal preserve。
Embodiment 2:
A kind of book on Chinese herbal medicine rhinitis ointment, the effective raw material being made up of following weight is made: Herba Centipedae: 20 parts, Aloe: 15 parts, Radix Sophorae Flavescentis: 15 parts, Cortex Phellodendri: 10 parts, Flos Magnoliae: 10 parts, the Radix Angelicae Dahuricae: 10 parts, Herba Menthae: 5 parts。
Also include the raw material of following weight composition: to the stupid methyl formate of hydroxyl: 1 part, dimethyl sulfoxide: 1 part, glycerol: 10 parts, water: 50 parts。
Method for making: its method for making is with the method for making of embodiment 1。
Embodiment 3:
A kind of book on Chinese herbal medicine rhinitis ointment, the effective raw material being made up of following weight is made: Herba Centipedae: 15 parts, Aloe: 10 parts, Radix Sophorae Flavescentis: 15 parts, Cortex Phellodendri: 10 parts, Flos Magnoliae: 9 parts, the Radix Angelicae Dahuricae: 8 parts, Herba Menthae: 5 parts。
Also include the raw material of following weight composition: to the stupid methyl formate of hydroxyl: 1 part, dimethyl sulfoxide: 1 part, glycerol: 10 parts, water: 40 parts。
Method for making: its method for making is with the method for making of embodiment 1。
Clinical report
Clinical data:
1, case scenario
Sinusitis: 500 examples；
Allergic rhinitis: 500 examples；
2, diagnosis basis: according to nasal obstruction for alternately with intermittent feature, in conjunction with clinical examination。
3, Therapeutic Method
By ointment directly with to nasal cavity, every day 2-3 time。
4, efficacy evaluation result
1. take a turn for the better: after medication, disease is improved。
2. cure: rehabilitation。
3. without changing: medication is invalid。
4. increase the weight of: aggravation after taking medicine。
5, therapeutic outcome (see table 1, table 2)
Table 1: rhinitis ointment of the present invention treats the clinical efficacy classification chart of 500 example sinusitis symptoms
Table 2: rhinitis ointment of the present invention treats the clinical efficacy classification chart of 500 example allergic rhinitis symptoms
Medication points for attention: a, avoid contact to glasses。B, to this product allergy sufferers disable, allergic constitution is cautious use of。C, Pregnant and lactant women should use under doctor instructs。D, effect duration are 24 months。
As can be seen from the table, applying clinical 1000 example of the present invention, effective percentage is 100%；Cure rate is 98%。
Clinical case data:
1, Zhao Dongmei, female, 24 years old, Anshan, liaoning Province people, symptom: long-term intermittent or alternately have a stuffy nose, cause dizziness, have a strong impact on sleep, working and learning。Glutinous purulence nasal mucus often blows back into pharyngeal cavity, cough, excessive phlegm occurs, diagnoses as chronic rhinitis。Medication: directly medication in nose, when 7 days, symptom disappears substantially, and 14 days, symptom all disappeared。Pay a return visit in 3 years, then without recurrence。
2, Tan Mingze, man, 38 years old, Anshan, liaoning Province people, symptom: many tears are often mucus or glutinous purulence, occasionally become purulence。Recur more than symptom when sending out sexy dye season；Tunica mucosa nasi swelling, nasal obstruction during recurrence, cause that olfactory sensation declines；Headache, inappetence, easily tired, hypomnesis, insomnia。Medication: directly medication in nose, when 7 days, symptom makes moderate progress, and is continuing with 7 days symptoms and all disappears。Pay a return visit in 5 years, then without recurrence。
3, Wang Kaiyu, man, 47 years old, people from Haicheng, symptom: rhinitis, long-term rhinorrhea, have a stuffed up nose gas, once in a while with headache, sneeze, personality is irritable, medication 6 days, and headache syndromes alleviates, nose is ventilated, and continues medication 10 days, head not bitterly, the basic rehabilitation of symptom, pay a return visit in 4 years, more no recurrence。
4, Li Yanhua, female, 60 years old, Xiu Yan people。Symptom: sinusitis, nasal obstruction, stuffiness, dizzy brain rises, and can't smell abnormal smells from the patient, sleeps bad, medication more than 10 sky, and symptom is substantially got better, and nose is ventilated。Head is not confused, and brain does not rise, feel of falling asleep, and pays a return visit, do not recur always after 4 years。
5, Li Xuesong。Female, 54 years old, Anshan, liaoning Province people, symptom: allergic rhinitis, run into cold air, pollen, the unknown cause such as special odor, can sneeze, rhinorrhea is with tear, medication 8 days, rhinorrhea symptom improves, also not sneeze, continues medication 15 days, and all symptoms disappear substantially。Pay a return visit in 5 years, in not recurrence。
Claims (3)
1. a herbal rhinitis ointment, it is characterized in that, constituent includes effective raw material of following composition by weight: Herba Centipedae: 10-20 part, Aloe: 5-15 part, Radix Sophorae Flavescentis: 10-15 part, Cortex Phellodendri: 5-10 part, Flos Magnoliae: 8-10 part, the Radix Angelicae Dahuricae: 5-10 part, Herba Menthae: 2-5 part。
2. a kind of book on Chinese herbal medicine rhinitis ointment according to claim 1, it is characterised in that constituent also includes the raw material of following composition by weight: to the stupid methyl formate of hydroxyl: 0.5-1 part, dimethyl sulfoxide: 0.5-1 part, glycerol: 5-10 part, water: 20-50 part。
3. the manufacture method of a book on Chinese herbal medicine rhinitis ointment as claimed in claim 1, it is characterised in that include step in detail below:
1) take Aloe according to above-mentioned parts by weight proportioning, Radix Sophorae Flavescentis, Cortex Phellodendri, Flos Magnoliae, the Radix Angelicae Dahuricae, Herba Menthae are put in container, and the water heating adding above-mentioned parts by weight decocts, and heating-up temperature is 100 DEG C, and heat time heating time is 2 hours, then carries medicinal liquid and removes medicinal residues；
2) medicinal liquid of decoction is carried out again second distillation concentration extraction cream liquid；
3) add in condensed cream above-mentioned parts by weight to the stupid methyl formate of hydroxyl, dimethyl sulfoxide part, glycerol, after being sufficiently stirred for mixing, stand, bottling seal preserve。
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110693962A (en) * | 2019-11-04 | 2020-01-17 | 冯丽 | Chinese herbal medicine rhinitis cream and preparation method thereof |
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Application publication date: 20160622 |