CN110693962A

CN110693962A - Chinese herbal medicine rhinitis cream and preparation method thereof

Info

Publication number: CN110693962A
Application number: CN201911066138.0A
Authority: CN
Inventors: 冯丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-04
Filing date: 2019-11-04
Publication date: 2020-01-17

Abstract

The invention provides a Chinese herbal medicine rhinitis cream and a preparation method thereof, and the composition components comprise the following raw materials by weight: 10-15 parts of dandelion, 10-15 parts of centipeda minima, 5-15 parts of indigo naturalis, 2-5 parts of lotus leaf, 10-15 parts of radix sophorae flavescentis, 2-5 parts of isatis root, 5-10 parts of golden cypress, 5-10 parts of liquorice, 5-10 parts of honeysuckle, 8-10 parts of ginkgo, 5-10 parts of radix angelicae, 3-5 parts of bighead atractylodes rhizome, 2-5 parts of divaricate saposhnikovia root, 5-10 parts of burdock and 2-5 parts of mint. The traditional Chinese medicine composition is used for treating rhinitis, nasosinusitis, allergic rhinitis and other symptoms, has the effects of ventilating, diminishing inflammation, clearing away fire and inhibiting bacteria, has a stable effect, does not have toxic or side effect, and has clinical practicability and pertinence.

Description

Chinese herbal medicine rhinitis cream and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a Chinese herbal medicine rhinitis ointment and a preparation method thereof.

Background

Rhinitis, an inflammatory disease of the nasal cavity, is inflammation of the mucous membrane of the nasal cavity caused by viruses, bacteria, allergens, various physicochemical factors and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of the nasal mucosa. Rhinitis symptoms are usually manifested as nasal obstruction, sneezing, nasal discharge and hyposmia, and most people are also usually accompanied by headache, dizziness, anorexia, easy fatigue, hypomnesis, insomnia and other symptoms.

When rhinitis occurs, the normal work and life of people are affected seriously by symptoms such as nasal obstruction, continuous sneezing, nasal discharge, headache and the like. Because the cause of rhinitis is complicated, patients can treat the symptoms but not the root causes when using some western medicines, and the treatment effect is not ideal. Moreover, some western medicines such as 0.5-1% ephedrine nasal drops used for a long time at present can damage nasal mucosa cilia structures and aggravate rhinitis more easily; bijing, which has been shown to cause rhinitis medicamentosa.

The traditional Chinese medicine is a treasure in China, can reach pharmacology, can be used for treating rhinitis and can treat both symptoms and root causes, and at present, some traditional Chinese medicine preparations for treating rhinitis are provided, but the components are different, and the curative effect is different.

Disclosure of Invention

The invention aims to provide the Chinese herbal medicine rhinitis cream and the preparation method thereof, the traditional process of the traditional Chinese medicine rhinitis cream is combined with the modern traditional Chinese medicine science and technology, and the traditional Chinese medicine rhinitis cream has the advantages of good curative effect, clear efficacy, convenience and simplicity in use, safety and no toxic or side effect. It can be used for treating rhinitis, sinusitis, turbinate swelling, allergic rhinitis, etc., and has effects of promoting qi circulation, relieving inflammation, clearing pathogenic fire, and inhibiting bacteria, and can be used for 7-15 days without discomfort.

In order to achieve the purpose, the invention adopts the following technical scheme:

the Chinese herbal medicine rhinitis ointment comprises the following raw materials in parts by weight: 10-15 parts of dandelion, 10-15 parts of centipeda minima, 5-15 parts of indigo naturalis, 2-5 parts of lotus leaf, 10-15 parts of radix sophorae flavescentis, 2-5 parts of isatis root, 5-10 parts of golden cypress, 5-10 parts of liquorice, 5-10 parts of honeysuckle, 8-10 parts of ginkgo, 5-10 parts of radix angelicae, 3-5 parts of bighead atractylodes rhizome, 2-5 parts of divaricate saposhnikovia root, 5-10 parts of burdock and 2-5 parts of mint.

The components also comprise the following raw materials in parts by weight: 0.5-1 part of dimethyl sulfoxide and 5-10 parts of glycerol.

A preparation method of Chinese herbal medicine rhinitis cream comprises the following specific steps:

1) drying radix Sophorae Flavescentis, cortex Phellodendri, semen Ginkgo and radix Angelicae Dahuricae in the sun, pulverizing, grinding into superfine powder, sieving with 140 mesh sieve, adding 10-50 parts of oleum Sesami, stirring, and standing in shade for 2 days;

2) adding yellow wine into herba Taraxaci, herba Centipedae, indigo naturalis, folium Nelumbinis, flos Lonicerae, radix Isatidis, Glycyrrhrizae radix, Atractylodis rhizoma, radix Saposhnikoviae, fructus Arctii, and herba Menthae, parching, taking out, adding water, heating and decocting at 100 deg.C for 2-3 hr, and extracting medicinal liquid to remove residue;

3) carrying out secondary distillation and concentration on the liquid medicine obtained by decoction in the step 2) to extract paste;

4) mixing the 2 medicines obtained in the step 1) and the step 3), adding dimethyl sulfoxide and glycerol, stirring and mixing fully, and standing for 2 days.

The dandelion in the invention has the following effects: clearing away heat and toxic material, eliminating swelling and dissipating stagnation, and cooling blood and relieving swelling, and is suitable for furuncle, sore throat, damp-heat, stranguria with heat, and pain. The centipeda minima has the effects of dispersing wind cold, relieving stuffy nose, relieving cough, detoxifying, relieving itching and the like. Efficacy of indigo naturalis: clearing away heat and toxic material, removing liver heat and purging fire, arresting convulsion, and is mainly used for warming toxicity, cooling blood and relieving swelling. The lotus leaf has the following effects: has effects in removing summer heat, eliminating dampness, invigorating qi, clearing yang, cooling blood, stopping bleeding, clearing away heart fire, calming liver fire, reducing lung fire, reducing weight, and removing fat. Radix sophorae flavescentis has: bitter, cold and nontoxic, excessive and dribbling after drowning, expelling water and removing carbuncle and swelling. The efficacy of the isatis root: clearing away heat and toxic materials, cooling blood and relieving swelling, resisting bacteria and diminishing inflammation, clearing excess heat and fire toxin, relieving sore throat and dissipating mass, and can also be used for treating pestilence. The efficacy of phellodendron bark: has the functions of clearing away toxic material, eliminating dampness, purging fire, detoxicating, etc. The efficacy of ginkgo is as follows: astringe lung, relieve asthma, kill bacteria, eliminate phlegm, relieve cough, protect liver, and resist tuberculosis. The liquorice has the following effects: clearing away heat and toxic material, and treating toxic diseases, pain, swelling, furunculosis, etc. Has effects in relieving inflammation, resisting allergy, protecting throat and organ mucosa, invigorating spleen and qi, moistening lung, relieving cough, relieving spasm, relieving pain, and alleviating drug effect. The honeysuckle has the effects of sweet and cold, fragrance evacuation, heat clearing and detoxifying, and heat transmission and expression, and can be used for treating diseases such as exogenous wind-heat, pharyngalgia and thirst. The white atractylodes rhizome has the effects of tonifying qi and spleen, and strengthening exterior and arresting sweating, and is commonly used for treating symptoms such as spleen qi deficiency and sweating, defensive qi weakness, exterior deficiency and spontaneous sweating, susceptibility to wind-cold and the like. Wind prevention: has the functions of dispelling wind and relieving exterior syndrome, resisting bacteria, dispelling wind and relieving exterior syndrome, and increasing smell, and can be used in combination with different Chinese medicines for treating wind-heat cold syndrome, exogenous wind-damp, headache, pharyngalgia and thirst, etc. The angelica dahurica has the following effects: the medicine is used as root medicine, has the functions of dispelling diseases, removing dampness, expelling pus, promoting granulation, promoting blood circulation, relieving pain and the like, and is mainly used for treating wind-cold type common cold, headache, rhinitis and toothache. The efficacy of the burdock is as follows: pungent, bitter, cold in nature and flavor, dispelling wind-heat, ventilating lung, promoting eruption and removing toxicity. The efficacy of mint: pungent and warm, non-toxic, refreshing head and eyes, and eliminating wind-heat. Dimethyl sulfoxide has strong permeability to skin as solvent of medicine, and is helpful for medicine permeation to human body and improving drug effect. The function of glycerol: antioxidant and softening agent.

Compared with the prior art, the invention has the beneficial effects that:

the Chinese herbal medicine rhinitis ointment is prepared by combining the traditional process with the modern traditional Chinese medicine technology, and has the advantages of good curative effect, clear effect, convenient and simple use, safety and no toxic or side effect. Can be used for treating rhinitis, sinusitis, turbinate swelling, allergic rhinitis, etc., and has effects of promoting qi circulation, relieving inflammation, clearing pathogenic fire, and inhibiting bacteria, and can be used for 7-15 days without discomfort.

Detailed Description

4) mixing the 2 medicines obtained in the step 1) and the step 3), adding dimethyl sulfoxide and glycerol, stirring and mixing fully, standing for 2 days, bottling, sealing and keeping in the shade.

[ FORMULATION ] A blackish brown ointment with fragrant smell.

[ APPLICATION RANGE ] for skin and mucous membrane.

[ METHOD OF USE ] IN THE NOSE CAVITY

[ shelf life ] 24 months.

The using method of the invention comprises the following steps: the medicine is directly applied into nasal cavity 2-3 times per day.

Example 1:

a Chinese herbal medicine rhinitis ointment is prepared from the following raw materials in parts by weight: 10 parts of dandelion, 15 parts of centipeda minima, 10 parts of indigo naturalis, 5 parts of lotus leaf, 10 parts of sophora flavescens, 5 parts of isatis root, 5 parts of phellodendron, 10 parts of liquorice, 10 parts of honeysuckle, 8 parts of ginkgo, 5 parts of angelica dahurica, 5 parts of bighead atractylodes rhizome, 5 parts of divaricate saposhnikovia root, 10 parts of burdock fruit, 2 parts of mint, 0.5 part of dimethyl sulfoxide and 5 parts of glycerol.

Example 2:

a Chinese herbal medicine rhinitis ointment is prepared from the following raw materials in parts by weight: 11 parts of dandelion, 12 parts of centipeda minima, 6 parts of indigo naturalis, 3 parts of lotus leaves, 14 parts of sophora flavescens, 3 parts of isatis roots, 6 parts of golden cypress, 7 parts of liquorice, 6 parts of honeysuckle, 9 parts of ginkgo, 7 parts of angelica dahurica, 4 parts of bighead atractylodes rhizome, 4 parts of divaricate saposhnikovia roots, 6 parts of burdock, 3 parts of mint, 1 part of dimethyl sulfoxide and glycerol: 10 parts.

Example 3:

a Chinese herbal medicine rhinitis ointment is prepared from the following raw materials in parts by weight: 13 parts of dandelion, 14 parts of centipeda minima, 10 parts of indigo naturalis, 4 parts of lotus leaves, 14 parts of sophora flavescens, 4 parts of isatis roots, 7 parts of golden cypress, 9 parts of liquorice, 9 parts of honeysuckle, 9 parts of ginkgo, 8 parts of angelica dahurica, 4 parts of bighead atractylodes rhizome, 3 parts of divaricate saposhnikovia roots, 9 parts of burdock, 4 parts of mint, 0.8 part of dimethyl sulfoxide and 7 parts of glycerol.

1. Case condition

-sinusitis: 500 cases are shown;

-allergic rhinitis: 500 cases are shown;

2. the basis of diagnosis is as follows: according to the characteristics of alternation and intermittence of the nasal obstruction, the nasal obstruction is combined with clinical examination.

3. The treatment method comprises the following steps: the ointment is directly applied into nasal cavity 2-3 times per day.

4. The result of the curative effect evaluation is as follows:

① the symptoms are improved after administration.

② it can be used for the treatment of diseases.

③ is ineffective, the medicine is ineffective.

5. Therapeutic results (see tables 1 and 2)

Table 1: clinical curative effect classification table for treating 500 cases of nasosinusitis symptoms by using rhinitis ointment

Table 2: clinical curative effect classification table for treating 500 cases of allergic rhinitis symptoms by using rhinitis ointment

As can be seen from the table, the invention is applied to 1000 clinical cases, and the effective rate is 100%; the cure rate is 87%.

Clinical case data:

1. zhang Yi, woman, 54 years old, West four town of Haicheng Liaoning, symptoms: the nasal obstruction, rhinorrhea, hyposmia, headache and other related symptoms can be caused when the nasal concha is enlarged, the mucopurulent rhinorrhea usually flows back into the pharyngeal cavity, cough and excessive phlegm appear, and the medicine is taken: the medicine is directly applied into nasal cavity, and applied once in the morning and evening with watery nasal discharge and sneeze, wherein symptoms basically disappear after the medicine is applied for 7 days, and symptoms completely disappear after 14 days. The disease is revisited within 1 year without relapse.

2. Chen in 14 years old men, and Tiedong district in Anshan city of Liaoning, symptoms: the nasal obstruction sneezes several times every day and several nasal noses each time, the nasal obstruction is clear water, the nose is itchy, the sense of smell is reduced, the attention is not concentrated in class, the symptoms such as memory decline and the like are accompanied, the nasal obstruction symptom is relieved after 3 days of medication, the nasal obstruction symptom is not remained, and the symptom basically disappears after 2 months of medication.

3. Zhengchi, male, 48 years old, and Sungshan mountain area, Liaoning, with symptoms: nasal discharge is usually mucous or purulent, with occasional purulent behavior. Symptoms recur more than in seasonal infections; nasal mucosa swelling and nasal obstruction during recurrence, which causes decreased smell; headache, anorexia, fatigue, hypomnesis, and insomnia. Administration: the medicine is directly applied to the nose, the symptoms are improved after 7 days, and the symptoms disappear after the medicine is continuously used for 7 days. The disease is revisited within 1 year without relapse.

4. Some king, male, 51 years old, in Liaoning sea city, with symptoms: rhinitis, running nose all the year round, stuffy nose, even and complicated headache, sneezing, impatient personality, 6 days of medication, alleviation of headache symptoms, ventilation of nose, continuous medication for 15 days, no headache, basic recovery of symptoms, return visit within 2 years and no relapse.

5. Some Liu, female, 66 years old, Xiuyan county of Liaoning. Symptoms are: nasosinusitis, nasal obstruction, stuffiness of the head, dizziness, bad sleep, taking 10 more days, obvious symptoms and nose ventilation. The head is not dizzy, the brain is not expanded, the people can feel asleep, and the disease is revisited after 1 year and half, and the disease does not relapse all the time.

6. Some king, female, 50 years old, liaoning saddletree, symptoms: allergic rhinitis can sneeze and rhinorrhea with tears when encountering cold air, pollen, special odor and other unknown reasons, the symptoms of rhinorrhea are improved and not sneezed after the administration for 12 days, and all symptoms basically disappear after the administration for 15 days. Visit again within 2 years without recurrence.

7. Qitong, male, 36 years old, liao ning liao yang county, with symptoms: the nasal concha is hypertrophic, the nasal discharge is caused all the year round, the nose is stuffy, the headache is accompanied, the sleep quality is poor, the attention is reduced, the nasal discharge symptom is improved after the medicine is taken for 7 days, and the insomnia symptom is improved after the medicine is taken for 1 month.

8. Some grand Su, male, 48 years old, Liaoning Dashiqiao city, symptoms: the nasal obstruction is sneezed when meeting cold air, the symptoms of nasal discharge are serious when seasons change, the symptoms are dizziness when the disease happens, the symptoms are obviously relieved after 10 days of administration, and the symptoms are smooth to breathe, clear and clear after 28 days of administration, and the symptoms completely disappear. Half a year later, the return visit is without relapse.

9. Certain Liu, male, 47 years old, Shenyang city and Pingyan, symptoms: nasosinusitis, nasal obstruction, rhinorrhea, dysosmia, dyspnea during morbidity, 10 days of medication, obvious relief of the symptoms of the nasal obstruction, 30 days of medication, smell of the nose, and no relapse after half a year of return visit.

10. Certain Soochou, female, 36 years old, Taian county Huangsha Tuo Zhen, symptoms of nasal septum deviation cause persistent nasal obstruction, nasal mucosa ischemia dryness, hyposmia, headache and intractable insomnia, the symptoms basically disappear after taking the medicine for 15 days, and the compound is reviewed after taking the medicine for 2 months without recurrence.

Claims

1. The Chinese herbal medicine rhinitis cream is characterized by comprising the following raw materials in parts by weight: 10-15 parts of dandelion, 10-15 parts of centipeda minima, 5-15 parts of indigo naturalis, 2-5 parts of lotus leaf, 10-15 parts of radix sophorae flavescentis, 2-5 parts of isatis root, 5-10 parts of golden cypress, 5-10 parts of liquorice, 5-10 parts of honeysuckle, 8-10 parts of ginkgo, 5-10 parts of radix angelicae, 3-5 parts of bighead atractylodes rhizome, 2-5 parts of divaricate saposhnikovia root, 5-10 parts of burdock and 2-5 parts of mint.

2. The Chinese herbal medicine rhinitis cream as claimed in claim 1, which is characterized by further comprising the following raw materials in parts by weight: 0.5-1 part of dimethyl sulfoxide and 5-10 parts of glycerol.

3. A method for preparing the Chinese herbal medicine rhinitis cream as claimed in claim 1 or 2, which is characterized by comprising the following specific steps:

4) mixing the 2 medicines obtained in the step 1) and the step 3), adding dimethyl sulfoxide and glycerol, fully stirring and mixing, and standing for 2 days.