CN114917298A

CN114917298A - Pharmaceutical composition for treating pneumonia and preparation method thereof

Info

Publication number: CN114917298A
Application number: CN202210492157.5A
Authority: CN
Inventors: 金明月; 李春梅; 王凤环
Original assignee: Sunlon Pharmaceutical Co ltd
Current assignee: Sunlon Pharmaceutical Co ltd
Priority date: 2022-05-07
Filing date: 2022-05-07
Publication date: 2022-08-19
Anticipated expiration: 2042-05-07
Also published as: CN114917298B

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating pneumonia and a preparation method thereof. The pharmaceutical composition comprises the following components in parts by weight: 10-15 parts of bulbus fritillariae cirrhosae, 2-10 parts of ephedra, 10-20 parts of loquat leaf, 5-10 parts of mint, 5-10 parts of fructus forsythiae, 2-5 parts of poria cocos, 2-5 parts of houttuynia cordata, 10-15 parts of honeysuckle, 2-5 parts of scutellaria baicalensis, 1-5 parts of fructus gardeniae, 5-15 parts of radix bupleuri, 2-10 parts of cortex mori radicis, 5-10 parts of codonopsis pilosula and 2-5 parts of oyster. The preparation method comprises the following steps: soaking the raw materials, decocting, and filtering to obtain filtrate and residue; refluxing and extracting filter residue by using an ethanol water solution; adding beta-cyclodextrin into the filtrate, stirring uniformly, and drying; adding the extract, cellulose and beta-cyclodextrin, mixing, drying and granulating. The medicine has effects of replenishing blood, nourishing blood, and improving immunity. Can not only treat pneumonia, but also enhance physique and treat both manifestation and root cause of disease.

Description

Pharmaceutical composition for treating pneumonia and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating pneumonia and a preparation method thereof.

Background

Pneumonia is a common respiratory disease, and is a parenchymal inflammation of the lung caused by various pathogens (e.g., bacteria, viruses, fungi, parasites, etc.). The main symptoms are hyperpyrexia, very rapid respiration, persistent dry cough, unilateral chest pain, chest pain during deep respiration and cough, small amount of phlegm or large amount of phlegm, and blood streak.

At present, most western medicines adopt anti-inflammatory medicines for treating pneumonia, and the anti-inflammatory medicines have quick response, but most of the anti-inflammatory medicines are antibiotics, and although the anti-inflammatory medicines have quick response, the anti-inflammatory medicines are easy to generate drug resistance, relapse is easy after stopping the medicine, and the treatment is temporary and permanent.

Pneumonia belongs to the categories of wind-warm syndrome, cough syndrome, lung-heat disease and the like in the traditional Chinese medicine. The traditional Chinese medicine considers that pneumonia is caused by wind-heat or wind-cold pathogen entering interior and transforming into heat when the healthy qi of human bodies is insufficient, such as overstrain, drunk wind and the like. The traditional Chinese medicine treatment is preferably to disperse wind, relieve obstruction, eliminate phlegm, relieve asthma, clear away heat and toxic materials, promote the production of body fluid and quench thirst. Flos Lonicerae, fructus forsythiae, Scutellariae radix, radix Isatidis, and flos Caryophylli can be added into the decoction of Maxingshigan. Modified Sanhuang Gao Tang for severe disease. For extreme heat impairing yin, restlessness and shortness of breath, Shengmai san or Sha Shen Mai Dong Tang may be added.

The traditional Chinese medicine for treating pneumonia has small side effect, treats both symptoms and root causes, but the traditional Chinese medicine formula is generally complex, has the defects of long treatment course, slow response and the like, is mostly decoction, and is relatively troublesome to take.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition for treating pneumonia, which utilizes the synergistic effect of various traditional Chinese medicinal materials to improve the curative effect of the medicine, has the effects of clearing away heat and toxic materials, eliminating phlegm and relieving asthma, and promoting the production of body fluid to quench thirst, and has the advantages of small side effect, short treatment course and remarkable curative effect.

The invention also aims to provide a preparation method of the pharmaceutical composition for treating pneumonia, which extracts water-soluble components in the traditional Chinese medicinal materials by soaking and decocting, extracts effective components in the medicine dregs by refluxing with ethanol water solution, fully utilizes the effective components of the traditional Chinese medicinal materials, and has high content of the effective components in the pharmaceutical composition so as to improve the curative effect of the medicine.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the invention provides a pharmaceutical composition for treating pneumonia, which comprises the following components in parts by weight: 10-15 parts of bulbus fritillariae cirrhosae, 2-10 parts of ephedra, 10-20 parts of loquat leaf, 5-10 parts of mint, 5-10 parts of fructus forsythiae, 2-5 parts of poria cocos, 2-5 parts of houttuynia cordata, 10-15 parts of honeysuckle, 2-5 parts of scutellaria baicalensis, 1-5 parts of fructus gardeniae, 5-15 parts of radix bupleuri, 2-10 parts of cortex mori, 5-10 parts of codonopsis pilosula and 2-5 parts of oyster.

On the other hand, the embodiment of the invention provides a preparation method of a pharmaceutical composition for treating pneumonia, S1 soaking the raw materials in a solvent, then decocting at 90-110 ℃ for 5-6h, and filtering to obtain filtrate and filter residue;

s2, crushing the filter residue, adding an ethanol water solution, and performing reflux extraction to obtain an extracting solution;

s3, adding a part of beta-cyclodextrin into the filtrate, uniformly stirring and drying to obtain a mixture;

s4 mixing the mixture obtained in step S3, the extracting solution, the cellulose and the other part of beta-cyclodextrin uniformly, drying and granulating.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

in the invention, the bulbus fritillariae cirrhosae, the loquat leaf, the radix bupleuri and other traditional Chinese medicinal materials are used in a compatibility manner, so that the effects of resisting bacteria, diminishing inflammation, clearing away heat and toxic materials, eliminating phlegm, relieving asthma, promoting the production of body fluid and quenching thirst can be achieved, and the traditional Chinese medicine has small side effect, short treatment course and obvious curative effect. The traditional Chinese medicinal materials such as tuckahoe, radix codonopsitis and the like are added and are compatible with the bulbus fritillariae cirrhosae, loquat leaf and the like, so that the medicine has the effects of enriching blood and nourishing blood, enhancing physique and improving organism immunity. Can not only treat pneumonia, but also enhance physique and treat both manifestation and root cause of disease.

When the medicine is prepared, the effective components of the traditional Chinese medicines are fully utilized by firstly extracting the medicine with water and then extracting the medicine with alcohol, so that the content of the effective components in the medicine composition is high, and the curative effect of the medicine is improved. Compared with the existing decoction processing of traditional Chinese medicines, the active ingredients in the traditional Chinese medicine composition are richer and the curative effect is better through alcohol extraction.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

On one hand, the embodiment of the invention provides a pharmaceutical composition for treating pneumonia, which comprises the following components in parts by weight: 10-15 parts of bulbus fritillariae cirrhosae, 2-10 parts of ephedra, 10-20 parts of loquat leaf, 5-10 parts of mint, 5-10 parts of fructus forsythiae, 2-5 parts of poria cocos, 2-5 parts of houttuynia cordata, 10-15 parts of honeysuckle, 2-5 parts of scutellaria baicalensis, 1-5 parts of fructus gardeniae, 5-15 parts of radix bupleuri, 2-10 parts of cortex mori radicis, 5-10 parts of codonopsis pilosula and 2-5 parts of oyster.

Bulbus Fritillariae Cirrhosae has effects of relieving cough, eliminating phlegm, moistening lung, and resolving hard mass. It can be used for treating chronic cough due to lung deficiency, cough due to asthenia, cough due to dryness-heat, pulmonary abscess, lymphoid tuberculosis, carbuncle, and mammary abscess.

The ephedra herb has the effects of inducing sweat to relieve exterior syndrome, ventilating and smoothing lung and relieving asthma, and inducing diuresis to alleviate edema. Mainly treats wind-cold exterior excess syndrome, cough and asthma, geomantic omen, dysuresia, rheumatism and arthralgia, skin incompetence, rubella and pruritus, dorsal furuncle and phlegm nodule.

Loquat leaves have the efficacies of clearing away lung-heat, relieving cough, harmonizing stomach, lowering adverse qi and quenching thirst. It can be used for treating cough due to lung heat, cough due to yin deficiency, cough, hemoptysis, epistaxis, hematemesis, stomach heat emesis, pernicious vomiting, infantile vomiting of milk, diabetes, and facial sore due to lung-wind.

Herba Menthae has effects of dispelling pathogenic wind heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing, and can be used for treating wind heat common cold, headache, sore throat, food stagnation, flatulence, aphtha, toothache, sore, scabies, urticaria, epidemic febrile disease, rubella pruritus, stagnation of qi due to depression of the liver, chest distress, hypochondriac pain, etc.

Fructus forsythiae has effects of clearing heat, removing toxic substances, resolving hard mass, and relieving swelling. It is indicated for warm heat, erysipelas, macula, carbuncle and ulcer, scrofula, urinary stranguria and other diseases.

Poria, with a bland flavor, has the property of ascending, producing body fluid, opening striae, nourishing water and inducing diuresis. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. It can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

The herba Houttuyniae is dried aerial part of houttuynia cordata Thunb of Saururaceae. Yu xing Cao is pungent in flavor and cold in nature and enters lung meridian. Has effects in clearing away heat and toxic materials, relieving swelling, treating sore, promoting urination, removing dampness, clearing away heat, relieving dysentery, invigorating stomach, and promoting digestion, and can be used for treating lung abscess, pyocutaneous disease, hematochezia, and heat accumulation in spleen and stomach due to excess heat, heat toxin, dampness, and disease heat.

The honeysuckle has the efficacy of clearing away heat and toxic materials. It can be used for treating fever due to affection of exogenous wind-heat or epidemic febrile disease, heatstroke, toxic heat, dysentery, carbuncle, furuncle, pharyngitis, and various infectious diseases.

Scutellariae radix has effects of clearing heat and eliminating dampness, clearing pathogenic fire and removing toxic substance, stopping bleeding, and preventing miscarriage, and can be used for treating damp warmth, summer dampness, chest distress and nausea, damp heat and fullness, dysentery, jaundice, cough due to lung heat, hyperpyrexia and polydipsia, blood heat and epistaxis, carbuncle, swelling, sore and toxin, and threatened abortion.

Gardenia jasminoides is the fruit of Gardenia jasminoides Ellis of Rubiaceae. Has effects in protecting liver, promoting function of gallbladder, lowering blood pressure, tranquilizing mind, stopping bleeding, and relieving swelling. It is used to treat icterohepatitis, sprain, contusion, hypertension, and diabetes.

Bupleurum root has the functions of harmonizing exterior and interior, soothing liver and raising yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia.

Cortex Mori is dry root bark of Morus alba L.of Moraceae of dicotyledon, with its nature and taste of sweet and cold, and enters lung and spleen channels, and has effects of purging lung heat, relieving asthma, promoting diuresis, and relieving swelling, and can be used for treating lung heat, cough, oliguria, edema, and swelling of skin. Also has blood pressure lowering, antiinflammatory, and anticancer effects.

Codonopsis pilosula is sweet in flavor and neutral in nature. Has effects in invigorating spleen, replenishing qi, quenching thirst, invigorating spleen, benefiting lung, nourishing blood, and promoting salivation. Can be used for treating deficiency of spleen-lung qi, anorexia, listlessness, cough, asthma, deficiency of qi and blood, sallow complexion, palpitation, short breath, thirst due to body fluid consumption, internal heat, and diabetes. Laziness in speaking, weakness of limbs, poor appetite, qi deficiency, deficiency of both qi and fluid, deficiency of both qi and blood, and sallow complexion due to blood deficiency.

The Concha Ostreae is shell of Ostrea. The main functional indications are as follows: astringe yin, subdue yang, check sweating, astringe essence, resolve phlegm and soften hard masses. It is indicated for fright epilepsy, vertigo, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid urine, metrorrhagia, leukorrhagia, scrofula and goiter. Can be used for treating palpitation, insomnia, vertigo, tinnitus, scrofula, subcutaneous nodule, lump in the abdomen, spontaneous perspiration, night sweat, nocturnal emission, metrorrhagia, gastralgia, and pantothenic acid.

In the invention, the bulbus fritillariae cirrhosae, the ephedra herb and the loquat leaf have the effects of relieving cough and reducing sputum, diffusing lung and relieving asthma, and clearing lung and relieving cough after being combined, and are mainly used for treating asthma, cough and other symptoms caused by pneumonia. The mint, the forsythia, the houttuynia cordata, the honeysuckle and the astragalus have the effects of clearing away heat and toxic materials, can remove foul breath in the lung and remove lung toxicity, and are matched with the fritillaria cirrhosa and the like to realize synergistic effect and treat the pulmonary inflammation. The radix Codonopsis and Poria have effects of promoting diuresis, eliminating dampness, invigorating spleen, calming heart, invigorating spleen, replenishing qi, quenching thirst, invigorating spleen, benefiting lung, improving qi and blood, improving body constitution, enhancing immunity, and reducing virus invasion.

In some embodiments of the invention, the traditional Chinese medicine components further comprise 5-6 parts of chrysanthemum and 4-5 parts of liquorice.

Chrysanthemum flower enters lung and liver meridians. Has the effects of dispelling pathogenic wind, clearing heat, suppressing hyperactive liver, improving eyesight, and clearing away heat and toxic materials.

The liquorice belongs to perennial herbs, has thick and strong roots and rhizomes, and is a tonifying Chinese herbal medicine. The medicinal parts are roots and rhizomes, and the medicinal root is cylindrical, 25-100 cm long and 0.6-3.5 cm in diameter. The skin has different elasticity, and the surface is reddish brown or grayish brown. The root and stem are cylindrical, the surface has bud mark, and the middle of the section has marrow. Light smell, sweet and special taste. The functions are mainly used for clearing away heat and toxic material, eliminating phlegm and relieving cough, and treating abdominal cavity and the like.

In the formula, the chrysanthemum and the liquorice are added, the effects of dispersing wind, clearing heat, calming liver, improving eyesight and clearing heat and toxic materials of the chrysanthemum are utilized, and the heat-clearing and detoxifying effects of the traditional Chinese medicine composition are further improved by matching with traditional Chinese medicinal materials such as mint and the like; by utilizing the heat-clearing and detoxifying, phlegm-eliminating and cough-relieving effects of the liquorice, the traditional Chinese medicinal materials such as the mint, the bulbus fritillariae cirrhosae and the like are matched to remove lung heat, eliminate phlegm and relieve cough, and the treatment effect is further improved.

In some embodiments of the invention, the traditional Chinese medicine components further comprise 5-6 parts of angelica sinensis, 2-5 parts of ligusticum chuanxiong hort and 2-10 parts of divaricate saposhnikovia root.

The angelica has the effects of enriching the blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness and lubricating intestines.

The ligusticum wallichii has the effects of promoting qi circulation, relieving depression, dispelling wind-dryness and dampness, promoting blood circulation and relieving pain. It can be used for treating wind cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, headache, rheumatic arthralgia, amenorrhea, dystocia, puerperal stagnation and pain, superficial infection, skin ulcer, etc.

Radix Saposhnikoviae has effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm. Can be used for treating exterior syndrome due to exogenous pathogenic factor, rubella, pruritus, rheumatalgia, tetanus, and spleen deficiency with excessive dampness.

The Chinese angelica is added into the formula, the blood replenishing and activating effects of the Chinese angelica are utilized to replenish qi and blood for the organism, and the Chinese angelica is matched with Chinese medicinal materials such as codonopsis pilosula and the like to strengthen the physique and improve the immunity of the organism. The ligusticum wallichii is added, and the effects of promoting qi circulation and relieving depression, dispelling wind and eliminating dampness, and promoting blood circulation and relieving pain of the ligusticum wallichii are utilized, and the angelica and the codonopsis pilosula are matched for promoting blood circulation and enriching blood, tonifying middle-jiao and Qi and improving the immunity of the organism.

In some embodiments of the invention, the traditional Chinese medicine components further comprise 2-5 parts of corydalis saxicola, 5-10 parts of dried orange peel and 2-5 parts of dendrobium officinale.

Herba corydalis Thalictrifoliae has effects of clearing heat, detoxicating, dispelling pathogenic wind and cold, and can be used for treating common cold, fever and cough caused by wind cold. The pericarpium Citri Tangerinae has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and eliminating phlegm.

The Dendrobium officinale has the effects of promoting the production of body fluid, nourishing the stomach, nourishing yin, clearing heat, moistening lung, tonifying the kidney, improving eyesight and strengthening waist. The dendrobium officinale has the function of promoting the production of body fluid, and is mainly used for promoting glandular secretion and organ movement. The dendrobium officinale can promote the phagocytosis function of macrophages of tumor-bearing animals, enhance the proliferation and differentiation of T lymphocytes and the activity of NK cells, and can obviously improve the serum hemolysin value of the tumor-bearing animals, so that the dendrobium officinale can prompt TPSH to have nonspecific immunity function, or specific cellular immunity and humoral immunity function, and improve the immunity of organisms.

The corydalis saxicola is added and is used together with chrysanthemum, mint and the like to clear away heat and toxic materials and dispel wind-cold; the dendrobium officinale is added to be used together with the codonopsis pilosula and the angelica, so that the immunity of the organism is improved.

In some embodiments of the invention, the traditional Chinese medicine components further comprise 5-10 parts of beta-cyclodextrin and 5-10 parts of cellulose. Beta-cyclodextrin and cellulose are used as wrapping wall materials, and the active ingredients of the traditional Chinese medicinal materials are wrapped into granules, so that the Chinese medicinal material is convenient to eat.

On the other hand, the embodiment of the invention provides a preparation method of a pharmaceutical composition for treating pneumonia, S1, soaking the raw materials in a solvent, then decocting for 5-6h at 90-110 ℃, and filtering to obtain filtrate and filter residue;

s3, adding a part of beta-cyclodextrin into the filtrate, stirring uniformly, and drying to obtain a mixture;

s4 mixing the mixture, the extractive solution, cellulose and the other part of beta-cyclodextrin uniformly, drying, and granulating.

In some embodiments of the invention, in the step S1, the solvent includes cellulase, hemicellulase, pectinase and water. Before water extraction, biological enzyme is added into a soaked solvent, enzymolysis is carried out by utilizing the biological enzyme, and cellulose and the like of the traditional Chinese medicinal materials are destroyed, so that the effective components of the traditional Chinese medicinal materials are quickly dissolved out, and the water extraction efficiency is improved.

In some embodiments of the invention, the mass ratio of the cellulase, the hemicellulase and the pectinase is 1: (0.5-1):(0.2-0.5). The traditional Chinese medicinal materials have high cellulose content, the cellulase is used as a main component, the enzymolysis efficiency can be improved, the hemicellulase and the pectinase are used as auxiliary components, the traditional Chinese medicinal materials are subjected to enzymolysis on a small amount of hemicellulose and pectin, the proportion is reasonable, the three cellulases can be fully utilized, and the comprehensive enzymolysis efficiency is high.

In some embodiments of the invention, in the step S2, the particle size of the crushed filter residue is 200-300 meshes, and the volume fraction of the ethanol aqueous solution is 50-60%. The grain size of the crushed medicine residue is reduced, the contact area of the medicine residue and the ethanol water solution is large, and the effective components are easier to dissolve out.

In some embodiments of the invention, the mass ratio of the β -cyclodextrin of step S3 to the β -cyclodextrin of step S4 is 1: (1-2).

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

Preparing tendrilleaf fritillary bulb 10Kg, Chinese ephedra 5Kg, loquat leaf 10Kg, peppermint 5Kg, capsule of weeping forsythia 5Kg, poria cocos wolf 2Kg, cordate houttuynia 5Kg, honeysuckle flower 10Kg, baikal skullcap root 2Kg, cape jasmine 1Kg, bupleurum root 10Kg, mulberry bark 2Kg, pilose asiabell root 5Kg and oyster 2 Kg.

The pharmaceutical composition is prepared as follows:

s1 adding 1Kg of cellulase, 0.5Kg of hemicellulase and 0.5Kg of pectinase into 40Kg of water, mixing uniformly to obtain a soaking solvent, soaking the Chinese medicinal materials in the soaking solvent for 48h, stirring once every 2h for 10min each time, and ensuring that the Chinese medicinal materials are completely soaked in the solvent. Decocting the Chinese medicinal materials and the soaking solvent at 100 + -2 deg.C for 6 hr, filtering, respectively collecting filtrate and residue, and concentrating the filtrate to obtain a concentrated filtrate with water content of 10 wt%.

S2 grinding the filter residue in a grinder, sieving with a 300-mesh sieve, adding 50% by volume of ethanol water solution, reflux-extracting in a reflux extraction device for 10h, collecting the extract, and concentrating to water content of 10 wt%.

S3 adding 2Kg of beta-cyclodextrin into the concentrated filtrate, stirring well, and drying to water content of 2 wt%.

S4 adding 2Kg of beta-cyclodextrin, 1Kg of cellulose and the dried mixture obtained in the step S3 into the concentrated extract, mixing uniformly, spray granulating and drying to obtain the pharmaceutical composition.

Example 2

Preparing 15Kg of bulbus fritillariae cirrhosae, 2Kg of ephedra, 15Kg of loquat leaf, 8Kg of mint, 8Kg of forsythia, 5Kg of tuckahoe, 2Kg of houttuynia cordata, 15Kg of honeysuckle, 3Kg of scutellaria baicalensis, 5Kg of gardenia, 5Kg of radix bupleuri, 5Kg of cortex mori radicis, 10Kg of codonopsis pilosula and 5Kg of oyster.

The pharmaceutical composition was prepared as follows:

s1 adding 1Kg of cellulase, 1Kg of hemicellulase and 0.2Kg of pectinase into 40Kg of water, mixing uniformly to obtain a soaking solvent, soaking the Chinese medicinal materials in the soaking solvent for 48h, stirring once every 2h for 10min each time, and ensuring that the Chinese medicinal materials are completely soaked in the solvent. Decocting the Chinese medicinal materials and the soaking solvent at 90 + -2 deg.C for 6 hr, filtering, respectively collecting filtrate and residue, and concentrating the filtrate to obtain a concentrated filtrate with water content of 10 wt%.

S2 grinding the filter residue in a grinder, sieving with a 300-mesh sieve, adding 60% ethanol water solution by volume fraction, performing reflux extraction in a reflux extraction device for 10h, collecting the extract, and concentrating to water content of 10 wt%.

S3 adding 1Kg of beta-cyclodextrin into the concentrated filtrate, stirring well, and drying to water content of 2 wt%.

S4 adding 2Kg of beta-cyclodextrin, 0.5Kg of cellulose and the dried mixture obtained in the step S3 into the concentrated extract, mixing uniformly, spray granulating, and drying to obtain the pharmaceutical composition.

Example 3

Preparing 12Kg of bulbus fritillariae cirrhosae, 10Kg of ephedra herb, 20Kg of loquat leaf, 10Kg of mint, 10Kg of forsythia fruit, 3Kg of tuckahoe, 3Kg of houttuynia cordata, 12Kg of honeysuckle flower, 5Kg of scutellaria baicalensis, 3Kg of gardenia, 10Kg of radix bupleuri, 10Kg of cortex mori radicis, 8Kg of codonopsis pilosula and 3Kg of oyster.

The pharmaceutical composition was prepared as follows:

s1 adding 1Kg of cellulase, 0.8Kg of hemicellulase and 0.3Kg of pectinase into 40Kg of water, mixing uniformly to obtain a soaking solvent, soaking the Chinese medicinal materials in the soaking solvent for 48h, stirring once every 2h for 10min each time, and ensuring that the Chinese medicinal materials are completely soaked in the solvent. Decocting the Chinese medicinal materials and the soaking solvent at 110 + -2 deg.C for 6 hr, filtering, respectively collecting filtrate and residue, and concentrating the filtrate to obtain a concentrated filtrate with water content of 10 wt%.

S2 grinding the filter residue in a grinder, sieving with a 200-mesh sieve, adding 50% ethanol water solution by volume fraction, performing reflux extraction in a reflux extraction device for 10h, collecting the extract, and concentrating to water content of 10 wt%.

S4 adding 3Kg of beta-cyclodextrin and 1Kg of cellulose, and the dried mixture obtained in the step S3 into the concentrated extract, mixing uniformly, spray granulating, and drying to obtain the pharmaceutical composition.

Example 4

5Kg of chrysanthemum and 4Kg of licorice were added on the basis of example 1. The rest is the same as in example 1.

Example 5

6Kg of chrysanthemum and 4.5Kg of licorice were added on the basis of example 1. The rest is the same as in example 1.

Example 6

5.5Kg of chrysanthemum and 5Kg of licorice were added on the basis of example 1. The rest is the same as in example 1.

Example 7

5Kg of angelica, 3Kg of chuanxiong rhizome and 10Kg of divaricate saposhnikovia root are added on the basis of the embodiment 4. The rest is the same as in example 4.

Example 8

6Kg of angelica, 2Kg of ligusticum chuanxiong hort and 8Kg of divaricate saposhnikovia root are added on the basis of the embodiment 4. The rest is the same as in example 4.

Example 9

5.5Kg of angelica, 5Kg of chuanxiong rhizome and 2Kg of divaricate saposhnikovia root are also added on the basis of the embodiment 4. The rest is the same as in example 4.

Example 10

5Kg of rumex japonicus, 6Kg of dried tangerine peel and 3Kg of dendrobium officinale are also added on the basis of the embodiment 7. The rest is the same as in example 7.

Example 11

On the basis of the embodiment 7, 3.5Kg of rumex japonicus, 10Kg of dried tangerine peel and 5Kg of dendrobium officinale are also added. The rest is the same as in example 7.

Example 12

On the basis of the embodiment 7, 2Kg of rumex japonicus, 5Kg of dried tangerine peel and 2Kg of dendrobium officinale are also added. The rest is the same as in example 7.

Examples of the experiments

1. Construction of mouse model for pneumonia

60 normal mice are selected and divided into 6 groups, each group comprises 10 mice, each group comprises half of the male and female mice, and virus inoculation is started after adaptive breeding is carried out for 2 days. On day 1, influenza virus was inoculated, normal mice were inoculated with normal saline by nasal drip, and the other mice were inoculated with 20. mu.L of influenza A H1N1 strain FM1 by nasal drip.

2. After 1 day of virus inoculation, the experimental groups were fed with the drugs of example 1, example 4, example 7 and example 10, respectively, 2 times per day, 1g each time; the normal group and model group mice were fed with the same amount of physiological saline and were continuously administered up to day 14.

The systemic responses including hair, activity, defecation, feeding, respiration, etc. were observed daily for each group of mice after infection with virus, and the daily body mass and death of the mice were recorded.

The normal group mice had good mental status and had acute response to the external environment. After 2 days of virus infection, the mice in the model group gradually appear the conditions of diet reduction and urine volume reduction, hair is easy to fall off, breath is short, sleepiness, conglobation is curled, aversion to cold and trembling, activity is dull, and spirit is listened. The status of each group of mice in the experimental group is shown in table 1.

Table 1 experimental group mouse status

As can be seen from table 1, after the pneumonia mice take the drugs of the examples, the mental states of the pneumonia mice gradually improve, and after the pneumonia mice take the drugs for 14 days, the mental states of the pneumonia mice of each experimental group are good, and the diet and urine volume are normal, which shows that the drugs of the examples have certain treatment effects on the pneumonia of the pneumonia mice.

On day 14 after drug administration, mice were sacrificed, the mass of the mice was weighed, the whole lungs were taken out and washed with physiological saline, surface water was blotted, the mass of the lungs was weighed, and the lung index and the lung inhibition rate of each group of mice were measured by calculating the lung index, wherein the lung index (lung mass/mouse mass) was multiplied by 100%, the lung index inhibition rate was multiplied by [ model group average lung index-experimental group average lung index ]/[ model group average lung index-blank control group average lung index ] × 100%, and the lung index inhibition rate of each group of mice was shown in table 2. After day 14, the mortality rate of each group of mice was counted, and the results are shown in Table 2

TABLE 2 pulmonary index of each group of mice

Example 1

Example 4

Example 7

Example 10

Model set

Normal group

Pulmonary index inhibition rate

25.3％

25.1％

24.6％

24.3％

/

Mortality rate

0

90％

0

As can be seen from the table 2, the medicament provided by the embodiment of the invention has an inhibition rate of 24-25% on the pulmonary index, and has a certain treatment effect on pneumonia. And none of the mice in the experimental group died during 14 days of treatment, while the mortality rate in the model group was 90%.

3 clinical test

40 pneumonia patients were selected and randomly divided into 4 groups, 10 patients in each group were clinically diagnosed as mild pneumonia, and the treatment effect was counted by taking the drugs of example 1, example 4, example 7 and example 10 at 3g each time and 2 times daily for 3 months. Wherein, curing: the clinical signs disappear and the normal state is restored. The effect is shown: the clinical signs of symptoms have substantially or mostly disappeared. The method has the following advantages: the clinical symptoms are obviously improved. And (4) invalidation: there was no improvement in clinical signs.

TABLE 3 therapeutic Effect of each group of drugs

	Example 1	Example 4	Example 7	Example 10
					Cure (example)	8	8	7	8
Obvious effect (example)	1	1	1	1
					Effective (example)	1	0	1	1
Invalid (example)	0	1	1	0
					High efficiency	100％	90％	80％	90％

Clinical experiments show that the cure rate of the medicine for treating mild pneumonia is more than 90%, the number of ineffective cases is small, and the treatment effect is good.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. The pharmaceutical composition for treating pneumonia is characterized by comprising the following components in parts by weight: 10-15 parts of bulbus fritillariae cirrhosae, 2-10 parts of ephedra, 10-20 parts of loquat leaf, 5-10 parts of mint, 5-10 parts of fructus forsythiae, 2-5 parts of poria cocos, 2-5 parts of houttuynia cordata, 10-15 parts of honeysuckle, 2-5 parts of scutellaria baicalensis, 1-5 parts of fructus gardeniae, 5-15 parts of radix bupleuri, 2-10 parts of cortex mori, 5-10 parts of codonopsis pilosula and 2-5 parts of oyster.

2. The pharmaceutical composition for treating pneumonia according to claim 1, characterized by further comprising, in parts by weight: 5-6 parts of chrysanthemum and 4-5 parts of liquorice.

3. The pharmaceutical composition for treating pneumonia according to claim 2, characterized by further comprising, in parts by weight: 5-6 parts of angelica, 2-5 parts of ligusticum chuanxiong hort and 2-10 parts of divaricate saposhnikovia root.

4. The pharmaceutical composition for treating pneumonia according to claim 3, further comprising 2-5 parts by weight of Hippocastane, 5-10 parts by weight of dried orange peel and 2-5 parts by weight of Dendrobium officinale.

5. The pharmaceutical composition for treating pneumonia according to claim 4, characterized by further comprising 5-10 parts by weight of beta-cyclodextrin and 5-10 parts by weight of cellulose.

6. A method of preparing a pharmaceutical composition for the treatment of pneumonia according to claim 5, comprising the steps of:

s1 soaking the raw materials in a solvent, decocting at 90-110 deg.C for 5-6h, and filtering to obtain filtrate and residue;

s4 mixing the mixture obtained in step S3, the extract, the cellulose and the other part of beta-cyclodextrin uniformly, drying and granulating.

7. The method for preparing a pharmaceutical composition for the treatment of pneumonia according to claim 6, wherein in said step S1, said solvent comprises cellulase, hemicellulase, pectinase and water.

8. The method for preparing the pharmaceutical composition for treating pneumonia according to claim 7, wherein the mass ratio of the cellulase, the hemicellulase and the pectinase is 1: (0.5-1):(0.2-0.5).

9. The method for preparing the pharmaceutical composition for treating pneumonia according to claim 6, wherein in the step S2, the particle size of the crushed filter residue is 200-300 meshes, and the volume fraction of the ethanol water solution is 50-60%.

10. The method for preparing a pharmaceutical composition for treating pneumonia according to claim 6, wherein the mass ratio of the beta-cyclodextrin of step S3 to the beta-cyclodextrin of step S4 is 1: (1-2).