CN101708275A - Chinese medicament for treating flu caused by influenza A(H1N1) and the like - Google Patents
Chinese medicament for treating flu caused by influenza A(H1N1) and the like Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Abstract
The invention discloses a Chinese medicament for treating the flu caused by influenza A(H1N1) and the like, which belongs to the technical field of Chinese medicament. The Chinese medicament is prepared from the following raw material medicaments: mix-fried ephedra herb, gypsum, honeysuckle flower, weeping forsythiae capsule, baical skullcap root, common anemarrhena rhizome, thunberg fritillary bulb, toasted almond, great burdock achene, sweet wormwood herb, peppermint, and raw licorice root. The Chinese medicament of the invention not only can have obvious healing effect on classical symptoms of the flu, such as fever, discomfort or soreness of the throat, cough and the like, has broad spectrum antibacterial effect, and is convenient for purchasing, decoction and administration because the raw medicinal materials are all common medicinal materials.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate in particular to Chinese medicine and the Chinese medicinal tablet and the granule technical field of the influenza that a kind of treatment causes by influenza virus such as H1N1s.
Background technology
Influenza (influenza is called for short influenza) is the acute respiratory infection that influenza virus causes, also is the disease that a kind of infectiousness is strong, spread speed is fast.Its mainly by the airborne spittle, interpersonal contact or with the contact transmission of contaminated article.Typical clinical symptoms is: anxious hyperpyrexia, whole body pain, the remarkable weak and slight respiratory symptom of rising.General autumn and winter season is its high-incidence season, and the caused complication and the phenomena of mortality are very serious.
Influenza virus can be divided into first (A), second (B), third (C), three types, and antigenic variation often takes place first type virus, and infectiousness is big, propagates rapidly, easily takes place popular on a large scale.
Influenza A H1N1 is called A (H1N1) type influenza again, be once called as people infected pigs influenza, influenza A H1N1 influenza virus is an A type influenza virus, carry H1N1 hypotype swine influenza virus strain, include ribonucleic acid (RNA) gene segment of North America and Eurasian swine flue, bird flu and three kinds of influenza virus of human influenza, have Asia swine flue and African swine influenza virus feature simultaneously.
The early symptom of influenza A H1N1 clinical manifestation is similar to ordinary people's influenza, comprise heating, cough, laryngalgia, physical distress, headache, heating etc., some also can occur diarrhoea or vomiting, myalgia or tired, eyes are rubescent etc., the part conditions of patients can make progress rapidly, break with tremendous force, suddenly hyperpyrexia, body temperature is above 39 ℃, even the serious pneumonia of secondary, acute respiratory distress syndrome, pneumorrhagia, hydrothorax, pancytopenia, renal failure, septicemia, shock and Reye syndrome, respiratory failure and multiple organ injury, cause death.The original underlying diseases of patient also can increase the weight of.
At present the patient to influenza generally uses antiviral drugs to treat, though the order of severity that these medicines can palliate a disease and improve chance for survival, expense is too high and because life-time service has caused some virus to produce drug resistance.
Summary of the invention
Think on the Chinese medicine to be influenza " exopathogen invasion ",, therefore be called " exopathogen " no matter, all belong to beyond the internal organs because viral cradle is nasal mucosa or respiratory tract.The traditional Chinese medical science is roughly divided " anemofrigid cold " and " anemopyretic cold " by the table note of the ancient Chinese and the somatic reaction classification of disease.Anemopyretic cold symptom: have sore throat, have a fever, have no appetite, rhinorrhea (dense thick, yellow green), thick sputum arranged.
2009 influenza A H1N1 belong to " epidemic febrile disease " category on Chinese medicine, what cause because of affection due to external wind and heat poison heresy is the clinical New Development infectious disease of feature with heating, throat discomfort or pain, cough, and the core pathogenesis of light disease is " the evil invasion and attack of wind heat poison lung is defended ".
The inventor is based on the Epidemic Febrile Disease opinion of studying the science, and the collection famous epidemic febrile disease scholar's in Beijing clinical experience integrates classics recipe MAXINGSHIGAN TANG, Lonicerae and Forsythiae Powder, Baihu Tang, has invented the Chinese medicine and the dosage form thereof of treatment influenza, thereby has finished the present invention.
Because influenza virus produces drug resistance to some Western medicine, so can't carrying out wide spectrum to cold virus, some antiviral drugs effectively treats, the objective of the invention is in order to address the above problem, performance Chinese medicine traditional advantage, Chinese medicine and the Chinese medicinal tablet and the granule of the influenza that a kind of treatment comprises influenza A H1N1 are provided, set about from initiatively removing body endogenous wind pathogenic heat poison aspect, improve the human body resistance against diseases.
Technical scheme of the present invention is as follows:
A kind of Chinese medicine for the treatment of influenza, wherein said Chinese medicine is made by following bulk drugs, and described crude drug comprises 10～30 parts of 3～9 parts of Herba Ephedrae (processed), 30～90 parts of Gypsum Fibrosum, 10～30 parts of Flos Loniceraes, 10～30 parts of Fructus Forsythiaes, 15～30 parts of Radix Scutellariaes, 6～20 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuaes.
Chinese medicine described in the technique scheme, the weight portion of wherein said each composition be 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes and 15 parts of Herba Artemisiae Annuaes.
Chinese medicine described in the technique scheme, wherein said crude drug also comprise 6～20 parts of Bulbus Fritillariae Thunbergiis, 3～10 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10～20 parts of Fructus Arctiis, 3～10 parts of Herba Menthaes.
Chinese medicine described in the technique scheme, the weight portion of wherein said each composition are 6 parts of 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis and Herba Menthaes.
Chinese medicine described in the technique scheme, wherein said crude drug also comprise 3～10 parts of Radix Glycyrrhizae.
Chinese medicine described in the technique scheme, the weight proportion of wherein said each composition are 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis, 15 parts of Herba Artemisiae Annuaes, 6 parts of Herba Menthaes, 10 parts of Radix Glycyrrhizae.
The preparation method of Chinese medicine of this treatment influenza is with described Chinese medicinal components decocting, or the pulverize immersion is quoted; Or other conventional method of Chinese medicine;
The purposes of the Chinese medicine of the influenza that this treatment is caused by influenza virus such as H1N1s is the purposes of preparation treatment cold medicine;
This flu is the flu that is caused by virus;
The purposes of the Chinese medicine of the influenza that this treatment is caused by influenza virus such as H1N1s is the medicine of preparation treatment cold, fever symptom.。
Chinese medicine of the present invention can also adopt the conventional method of Chinese medicine preparation to be prepared into any other conventional oral preparations, and the Chinese medicine in Chinese medicinal tablet and the capsule and the ratio of carrier can be used conventional weight ratio.
Herba Ephedrae (processed) is warm in nature in the above-mentioned raw materials medicine, and acrid in the mouth, little hardship have the effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; Gypsum Fibrosum Great Cold, acrid in the mouth, sweet, the effect that has clearing away heat-fire, relieving restlessness to quench the thirst; Flos Lonicerae sweet in the mouth cold in nature has heat-clearing and toxic substances removing, cool effect of loosing; Fructus Forsythiae cold nature bitter in the mouth has the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Rhizoma Anemarrhenae nature and flavor bitter cold has clearing away heat-fire, the effect of promoting the production of body fluid and moisturizing; Radix Scutellariae nature and flavor bitter cold has heat clearing and damp drying, the effect of eliminating fire and detoxication, and Herba Artemisiae Annuae is cold in nature, and bitter in the mouth, suffering have clearing away summer-heat, remove and steam, the effect of preventing the attack (or recurrence) of malaria; Herba Ephedrae (processed) dispelling wind to relieve the exterior syndrome, Gypsum Fibrosum heat clearing away expelling pathogenic factors from muscles are defended at the evil invasion and attack of poison lung and to be monarch drug; Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Artemisiae Annuae and the Rhizoma Anemarrhenae have heat-clearing and toxic substances removing, strengthen the power of heat clearing away, increase the effect of the property of detoxifcation, is this side's ministerial drug;
Stir-baked SEMEN ARMENIACAE AMARUM slightly warm in nature bitter in the mouth has the effect of sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation; Bulbus Fritillariae Thunbergii nature and flavor bitter cold has the effect of heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing; Fructus Arctii is cold in nature, and acrid in the mouth, hardship have the effect of evacuation, lung qi dispersing rash, resolving toxin and disinhibiting the throat; Add cool in nature, the acrid in the mouth of Herba Menthae, dispelling wind is arranged, dispel the heat, ward off dirty, antidotal effect; Adding Bulbus Fritillariae Thunbergii, stir-baked SEMEN ARMENIACAE AMARUM have the effect of preventing phlegm from forming and stopping coughing, and Fructus Arctii, Herba Menthae have the adjuvant drug that act as of expelling pathogenic factors from the exterior sore-throat relieving;
The flat sweet in the mouth of Radix Glycyrrhizae has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; Add the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, making the efficacy of a drug stay in the part of the body cavity above the diaphragm housing the heart and lungs is messenger drug, this side's collection classics recipe MAXINGSHIGAN TANG, Lonicerae and Forsythiae Powder, Baihu Tang are one, has dispelling wind and heat pathogens, the effect of heat-clearing and toxic substances removing, it is red red etc. that the evil invasion and attack of treatment wind heat poison lung is defended heating, throat discomfort or the pain, cough, the throat that cause, is used for upper respiratory tract infection that influenza A H1N1 and other virus causes and has the invasion and attack lung and defend card.
Chinese medicine of the present invention and Chinese medicinal tablet and granule have following beneficial effect:
1, crude drug of the present invention all is common medical materials, and the patient can buy and decoction very easily;
2,, bring financial burden therefore can for patient's treatment, thereby remove patient's trouble and worry from because selected Chinese crude drug all is common medical materials;
3, Chinese medicine of the present invention can have tangible curative effect to classical symptom such as heating, throat discomfort or pain, the cough etc. of the influenza that comprises influenza A H1N1;
4,, can effectively treat antiviral drugs such as oseltamivir phosphate capsule are had the caused influenza of chemical sproof virus because the characteristic of the broad-spectrum antiseptic of Chinese medicine.
Below further specify the beneficial effect that the present invention has by testing example, these test examples have comprised the clinical observation on the therapeutic effect test of Chinese medicine extract of the present invention.
Test example 1: medicine of the present invention and oseltamivir phosphate capsule are in the contrast of treatment influenza A H1N1
1, patient's alternative condition:
394 patients of examination, all patients all meet (1), meet the diagnostic criteria that Ministry of Public Health is formulated, (2), 14-70 the year, (3), disease time (heating occurring, axillaty temperature 〉=37.5 ℃ companion's pharyngalgia, cough symptom)≤72 hours
Exclusion standard: (1), gestation, (2), pneumonia, sick, the immunodeficiency in serious basis, (3), take antiviral agents before going into group, (4), organ function depletion arranged
2, group:
Blank group, oseltamivir phosphate capsule (Oseltamivir) group, medicine group of the present invention (to call Chinese drug-treated group in the following text) and (oseltamivir phosphate capsule+Chinese medicine) group are set respectively, and wherein the oseltamivir phosphate capsule group is taken and is taken Chinese medicine 200ml three nights one of daytime at oseltamivir phosphate capsule 75mg Bid three nights one of daytime, Chinese drug-treated group, (oseltamivir phosphate capsule+Chinese medicine) is organized and taken (oseltamivir phosphate capsule 75mg Bid+ Chinese medicine 200ml) three nights one of daytime
3, demographic characteristics: (n=394)
4, Clinical symptoms: (n=394)
| Blank group | The oseltamivir phosphate capsule group | Chinese drug-treated group | Oseltamivir phosphate capsule Combined with Chinese Herbal group | ??P | |
| High fever | ??0.673 | ||||
| ??≤38℃ | ??21 | ??24 | ??28 | ??24 | |
| ??38.1-39℃ | ??50 | ??50 | ??60 | ??53 |
| Blank group | The oseltamivir phosphate capsule group | Chinese drug-treated group | Oseltamivir phosphate capsule Combined with Chinese Herbal group | ??P | |
| ??≥39℃ | ??21 | ??24 | ??15 | ??24 | |
| Cough | ??72 | ??72 | ??78 | ??72 | ??0.712 |
| Pharyngalgia | ??54 | ??43 | ??66 | ??63 | ??0.016 |
| Headache | ??39 | ??45 | ??45 | ??46 | ??0.957 |
| Rhinorrhea | ??24 | ??24 | ??19 | ??23 | ??0.608 |
| Nasal obstruction | ??17 | ??15 | ??15 | ??22 | ??0.515 |
| Expectoration | ??26 | ??16 | ??18 | ??14 | ??0.665 |
5, MAIN OUTCOME MEASURES assessment:
6, less important observation index:
| Index | Blank group | The oseltamivir phosphate capsule group | Chinese drug-treated group | Oseltamivir phosphate capsule Combined with Chinese Herbal group | ??P |
| Dispensing-remission time (hr) | |||||
| Cough | ??4 | ??4 | ??4 | ??4 | ??0.217 |
| Pharyngalgia | ??2 | ??2 | ??3 | ??3 | ??0.258 |
| Expectoration | ??3 | ??3 | ??3 | ??3 | ??0.754 |
| Rhinorrhea | ??3 | ??1 | ??2 | ??1.5 | ??0.367 |
| Index | Blank group | The oseltamivir phosphate capsule group | Chinese drug-treated group | Oseltamivir phosphate capsule Combined with Chinese Herbal group | ??P |
| Headache | ??2 | ??1 | ??2 | ??1 | ??0.153 |
| Nasal obstruction | ??2 | ??2 | ??2 | ??2 | ??0.540 |
| Muscular soreness | ??1 | ??1 | ??1 | ??1 | ??0.945 |
| Weak | ??2 | ??1 | ??2 | ??2 | ??0.945 |
7, complication, complication, antibiotic:
8, length of stay:
The oseltamivir phosphate capsule group is organized relatively P=0.041 with uniting; Compare all＞0.05 between other each groups
9, pharmacoeconomics:
10, drug compliance:
All more satisfactory wherein 2 examples of compliance go into to organize to treat left hospital in 3 days (Chinese drug-treated group and drug combination group be 1 example respectively), and 3 examples are gone into group and treated left hospital in 4 days (blank, oseltamivir phosphate capsule and drug combination group be 1 example respectively).
11, drug safety:
Chinese drug-treated group 1 example is felt sick, is vomitted, and can not tolerate the premature termination test.
12, preliminary study result:
(1), three treatment groups effect of bringing down a fever all significantly is better than blank group;
(2), Chinese medicine is compared with Ao Sitawei: curative effect is similar, and the medicine expense is few;
(3), therapeutic alliance group does not show advantage.
Test example 2: medicine of the present invention causes the influence of fever in rabbit body temperature to endotoxin
1, test material
A, be subjected to reagent thing medicine of the present invention, containing 2g crude drug/ml Institute Of Chinese Materia Medica Of China Academy of Chinese Medical Sciences and dosage form chamber provides lot number: 090811.Clinical consumption is 148g/ day, is calculated as 2.47g/kg by 60 kg body weight, and the clinical equivalent dosage and the dosage that doubles are selected in test for use, rabbit with 15.30,7.65g/kg.
B, positive control drug aspirin effervescent tablets, AstraZeneca pharmaceutical Co. Ltd produces, and lot number is 080217,1 slice/day of clinical consumption (every contains 0.5g), be calculated as 0.017/kg by 60 kg body weight, clinical equivalent dosage is selected in test for use, and rabbit is used 0.025g/kg.
C, animal rabbit, 1.5-2.0kg, male and female half and half, tonneau laboratory animal plant provides by the Xueyaun Road, Haidian District, Beijing City, the quality certification number: SCKX (capital) 2005-0003.
D, endotoxin escherichia coli endotoxin, the Sigma product is available from Beijing naval of section boat biotech development center.
E, instrument 7151 type thermisters, Shanghai Medical Instrument and Meter Factory produces.
2, test method and result
Method by the 244th page of " herbal pharmacology research methodology " (People's Health Publisher, Beijing, 1993) of Qi Chen chief editor detects medicine of the present invention causes fever in rabbit body temperature to endotoxin influence
Method is got healthy rabbits and is weighed, and the same day was surveyed normal rectal temperature 2 times in test.Selecting the anus temperature to differ 0.4 ℃ 38.5-39.5 ℃ and twice temperature is for experiment with interior animal.Test is established 6 groups, 6 every group altogether.Be respectively model control group, positive control drug group, two dosage groups of medicine of the present invention (seeing table for details).Escherichia coli endotoxin with 140ng/ml/kg is injected by tame rabbit ear vein, after 1 hour, surveys anus temperature rise value, gives relative medicine by irritating stomach respectively after the lift-off value adjustment grouping.Model control group is irritated the distilled water of stomach with volume.Respectively surveyed the anus temperature once in 1,2,3,4 hour behind the medicine, surveyed anus temperature and basic anus using warming therapy difference, be the body temperature changing value with different time.
Table 1 medicine of the present invention is to the influence of endotoxin pyrogenic rabbit body temperature
Annotate: number of animals is 6; Compare * P＜0.05**P＜0.01 with model control group; Adopt the repeated measure variance analysis, prescription 2 heavy dose of groups and model group be P＜0.05 relatively
3, result
The result as shown in Table 1, the 15.30g/kg dosage of medicine of the present invention causes that to endotoxin the fervescence of rabbit has certain inhibition effect.
The specific embodiment:
For making technical scheme of the present invention be convenient to understand, the present invention is further illustrated below in conjunction with experimental example.
Embodiment 1:
Take by weighing 10 parts of 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuaes, with being decocted in water for oral dose, every day potion.
Embodiment 2:
Take by weighing 3 parts of Herba Ephedrae (processed), 90 parts of Gypsum Fibrosum, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 20 parts of Radix Scutellariaes, 6 parts of the Rhizoma Anemarrhenaes and and 15 parts of Herba Artemisiae Annuaes, with being decocted in water for oral dose, every day potion.
Embodiment 3:
Take by weighing 9 parts of Herba Ephedrae (processed), 60 parts of Gypsum Fibrosum, 30 parts of Flos Loniceraes, 30 parts of Fructus Forsythiaes, 30 parts of Radix Scutellariaes, 20 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuae 30, with being decocted in water for oral dose, every day potion.
Herba Ephedrae (processed) dispelling wind to relieve the exterior syndrome, Gypsum Fibrosum heat clearing away expelling pathogenic factors from muscles among the embodiment 1,2,3 are defended at the evil invasion and attack of poison lung and to be monarch drug; Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Herba Artemisiae Annuae and the Rhizoma Anemarrhenae have heat-clearing and toxic substances removing, strengthen the power of heat clearing away, increase the effect of the property of detoxifcation, is this side's ministerial drug.
Embodiment 4:
Take by weighing 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis and Herba Artemisiae Annuae 10, Herba Menthae 3, with being decocted in water for oral dose, every day potion.
Embodiment 5:
Take by weighing 3 parts of Herba Ephedrae (processed), 90 parts of Gypsum Fibrosum, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 20 parts of Radix Scutellariaes, 6 parts of the Rhizoma Anemarrhenaes, 6 parts of Bulbus Fritillariae Thunbergiis, 3 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 20 parts of Fructus Arctiis and Herba Artemisiae Annuae 15, Herba Menthae 10, with being decocted in water for oral dose, every day potion.
Embodiment 6:
Take by weighing 9 parts of Herba Ephedrae (processed), 60 parts of Gypsum Fibrosum, 30 parts of Flos Loniceraes, 30 parts of Fructus Forsythiaes, 30 parts of Radix Scutellariaes, 20 parts of the Rhizoma Anemarrhenaes, 20 parts of Bulbus Fritillariae Thunbergiis, 6 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10 parts of Fructus Arctiis and Herba Artemisiae Annuae 10, Herba Menthae 6, with being decocted in water for oral dose, every day potion.
Embodiment 4,5,6 has increased stir-baked SEMEN ARMENIACAE AMARUM, Bulbus Fritillariae Thunbergii and Fructus Arctii on the basis of embodiment 1,2,3, stir-baked SEMEN ARMENIACAE AMARUM slightly warm in nature bitter in the mouth wherein has the effect of sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation; Bulbus Fritillariae Thunbergii nature and flavor bitter cold has the effect of heat clearing away eliminating stagnation, preventing phlegm from forming and stopping coughing; Fructus Arctii is cold in nature, and acrid in the mouth, hardship have the effect of evacuation, lung qi dispersing rash, resolving toxin and disinhibiting the throat, have strengthened the heat clearing away eliminating stagnation of medicine, the curative effect of evacuation.
Embodiment 7:
Take by weighing Herba Ephedrae (processed) 6g, Gypsum Fibrosum 30g, Flos Lonicerae 15g, Fructus Forsythiae 15g, Radix Scutellariae 15g, Rhizoma Anemarrhenae 10g, Bulbus Fritillariae Thunbergii 10g, stir-baked SEMEN ARMENIACAE AMARUM 9g, Fructus Arctii 15g, Herba Artemisiae Annuae 15g, Herba Menthae 6g, Radix Glycyrrhizae 10g, with being decocted in water for oral dose, every day potion.
Embodiment 8:
Take by weighing 3 parts of Herba Ephedrae (processed), 90 parts of Gypsum Fibrosum, 10 parts of Flos Loniceraes, 10 parts of Fructus Forsythiaes, 20 parts of Radix Scutellariaes, 6 parts of the Rhizoma Anemarrhenaes, 6 parts of Bulbus Fritillariae Thunbergiis, 3 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 20 parts of Fructus Arctiis, Herba Artemisiae Annuae 10g, Herba Menthae 3g, Radix Glycyrrhizae 6g, with being decocted in water for oral dose, every day potion.
Embodiment 9:
Take by weighing 9 parts of Herba Ephedrae (processed), 60 parts of Gypsum Fibrosum, 30 parts of Flos Loniceraes, 30 parts of Fructus Forsythiaes, 30 parts of Radix Scutellariaes, 20 parts of the Rhizoma Anemarrhenaes, 20 parts of Bulbus Fritillariae Thunbergiis, 6 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10 parts of Fructus Arctiis, Herba Artemisiae Annuae 30g, Herba Menthae 10g, Radix Glycyrrhizae 3g, with being decocted in water for oral dose, every day potion.
Embodiment 7～9 has increased Herba Artemisiae Annuae, Herba Menthae and Radix Glycyrrhizae on the basis of embodiment 4～6, wherein Herba Artemisiae Annuae is cold in nature, and bitter in the mouth, suffering have clearing away summer-heat, removes and steams, the effect of preventing the attack (or recurrence) of malaria; Cool in nature, the acrid in the mouth of Herba Menthae has dispelling wind, dispels the heat, wards off dirty, antidotal effect; The flat sweet in the mouth of Radix Glycyrrhizae has the effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, and auxiliary all the other medicines of these three kinds of medicines are given full play to clinical efficacy.
Embodiment 10:The preparation of Chinese medicinal tablet of the present invention:
(1) granulates: take by weighing Chinese medicine and the carboxymethyl starch sodium that arbitrary embodiment makes among the embodiment 1～9 in 3: 1 ratio of mass ratio according to Chinese medicine and carboxymethyl starch sodium, and carboxymethyl starch sodium is divided into two fens, portion is that 1/3 amount is standby, another part is that 2/3 amount joins in the active component, with concentration is that 70% ethanol is that wetting agent is granulated, and the granule that makes is dry down in 60 ℃;
(2) tabletting: get dried particles, add the carboxymethyl starch sodium of 1/3 standby amount and the magnesium stearate of tablet total weight amount 0.3%, depress to tablet with 3kN pressure.
Embodiment 11:The preparation of Chinese medicine granules of the present invention
Take by weighing the medical material described in arbitrary embodiment among the embodiment 1～9, decoct with water twice, filter, get filtrate, dry spissated extractum adds the lactose of 4 times of amounts of Chinese medicine, mixing, granulates promptly.
Herba Ephedrae (processed), Gypsum Fibrosum are this side's main medicines in the present invention, Flos Lonicerae, Fructus Forsythiae, the Rhizoma Anemarrhenae and Radix Scutellariae, it is the important ancillary drug of prescription, formed the core of prescription jointly with Herba Ephedrae (processed), Gypsum Fibrosum, it is the principal agent of therapeutic effect, stir-baked SEMEN ARMENIACAE AMARUM, Bulbus Fritillariae Thunbergii, Fructus Arctii are the piths of strengthening this side's curative effect, and Herba Artemisiae Annuae, Herba Menthae, the auxiliary above medicine of Radix Glycyrrhizae are given full play to clinical efficacy.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any formal and substantial restriction, all those skilled in the art, in not breaking away from the technical solution of the present invention scope, when can utilizing the above technology contents that discloses, and a little change of making, modify the equivalent variations with differentiation, be equivalent embodiment of the present invention; Simultaneously, all foundations essence technology of the present invention all still belongs in the scope of technical scheme of the present invention change, modification and the differentiation of any equivalent variations that above embodiment did.
Claims (10)
1. the Chinese medicine of the influenza that causes by influenza virus such as H1N1s of a treatment, it is characterized in that: described Chinese medicine is made by following bulk drugs, and described crude drug comprises 10～30 parts of 3～9 parts of Herba Ephedrae (processed), 30～90 parts of Gypsum Fibrosum, 10～30 parts of Flos Loniceraes, 10～30 parts of Fructus Forsythiaes, 15～30 parts of Radix Scutellariaes, 6～20 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuaes.
2. the Chinese medicine of the influenza that treatment according to claim 1 is caused by influenza virus such as H1N1s is characterized in that: the weight portion of described each composition is 15 parts of 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes and Herba Artemisiae Annuaes.
3. the Chinese medicine of the influenza that treatment according to claim 1 is caused by influenza virus such as H1N1s is characterized in that: described crude drug also comprises 3～10 parts of 6～20 parts of Bulbus Fritillariae Thunbergiis, 3～10 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 10～20 parts of Fructus Arctiis and Herba Menthaes.
4. the Chinese medicine of the influenza that treatment according to claim 3 is caused by influenza virus such as H1N1s is characterized in that: the weight portion of described each composition is 6 parts of 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis and Herba Menthaes.
5. the Chinese medicine of the influenza that treatment according to claim 3 is caused by influenza virus such as H1N1s, it is characterized in that: described crude drug also comprises 3～10 parts of Radix Glycyrrhizae.
6. the Chinese medicine of the influenza that treatment according to claim 5 is caused by influenza virus such as first type H1 N1, it is characterized in that: the weight proportion of described each composition is 6 parts of Herba Ephedrae (processed), 30 parts of Gypsum Fibrosum, 15 parts of Flos Loniceraes, 15 parts of Fructus Forsythiaes, 15 parts of Radix Scutellariaes, 10 parts of the Rhizoma Anemarrhenaes, 10 parts of Bulbus Fritillariae Thunbergiis, 9 parts of stir-baked SEMEN ARMENIACAE AMARUMs, 15 parts of Fructus Arctiis, 15 parts of Herba Artemisiae Annuaes, 6 parts of Herba Menthaes, 10 parts of Radix Glycyrrhizae.
7. the preparation method of Chinese medicine of an influenza that causes by influenza virus such as H1N1s as the treatment of claim 1-6, it is characterized in that: described preparation method is with described Chinese medicinal components decocting, or pulverize soaks and drinks; Or other conventional method of Chinese medicine.
8. the purposes of the Chinese medicine of an influenza that is caused by influenza virus such as H1N1s as the treatment of claim 1-6 is the purposes of preparation treatment cold medicine.
9. the purposes of the Chinese medicine of the influenza that treatment according to claim 8 is caused by influenza virus such as H1N1s, it is characterized in that: described flu is the flu that is caused by virus.
10. the purposes of the Chinese medicine of an influenza that is caused by influenza virus such as H1N1s as the treatment of claim 1-6 is the medicine of preparation treatment cold, fever symptom.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102501386A CN101708275B (en) | 2009-11-27 | 2009-11-27 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
| PCT/CN2009/001378 WO2011063553A1 (en) | 2009-11-27 | 2009-12-04 | Traditional chinese medicine for treating flu induced by flu virus including type a h1n1 virus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102501386A CN101708275B (en) | 2009-11-27 | 2009-11-27 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
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| CN101708275B CN101708275B (en) | 2012-11-28 |
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| WO (1) | WO2011063553A1 (en) |
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| Publication number | Publication date |
|---|---|
| WO2011063553A1 (en) | 2011-06-03 |
| CN101708275B (en) | 2012-11-28 |
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