CN1559524A - Medicine for treating child cough and dyspnea due to the lung-heat and its preparaton method - Google Patents
Medicine for treating child cough and dyspnea due to the lung-heat and its preparaton method Download PDFInfo
- Publication number
- CN1559524A CN1559524A CNA2004100141824A CN200410014182A CN1559524A CN 1559524 A CN1559524 A CN 1559524A CN A2004100141824 A CNA2004100141824 A CN A2004100141824A CN 200410014182 A CN200410014182 A CN 200410014182A CN 1559524 A CN1559524 A CN 1559524A
- Authority
- CN
- China
- Prior art keywords
- medicine
- asthma
- radix
- lung heat
- heat cough
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of effervescent tablet for treatinginfantal cough and asthma is prepared from 11 Chinese-medicinal materials including bitter almond, gypsum, liquorice root, honeysuckle flower, etc and 5 medicinal additives including citric aci, dicarbonate, lactose, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of medicine of making by herbal raw material, particularly a kind of medicine for the treatment of the infantile lung heat cough with asthma; The invention still further relates to the preparation method of this kind medicine.
Background technology
The disease of infantile lung heat cough with asthma is a kind of children's's a commonly encountered diseases.Its clinical manifestation is a fever and sweating, and micro evil wind is cold, cough, expectorant Huang, or double panting, xerostomia and wait disease yearningly; Western medicine diagnose is upper respiratory tract infection, bronchitis etc.
In the prior art, the medicine of treatment infantile lung heat cough illness has infantile lung heat cough with asthma oral liquid.It is with making oral liquid by 11 flavor medicines such as Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Glycyrrhizae, Flos Lonicerae, Fructus Forsythiae, the Rhizoma Anemarrhenae, Radix Scutellariae, Radix Isatidis, Radix Ophiopogonis, Herba Houttuyniae and adjuvant sucrose, sodium benzoate.This oral liquid is a brown liquid, and it is sweet to distinguish the flavor of, and little hardship has heat-clearing and toxic substances removing, the effect of dispersing lung-QI and dissipating phlegm.Usage and dosage is: oral, and 1 years old to 3 years old each 10ml, 3 times on the one; 4 years old to 7 years old each 10ml, 4 times on the one; 8 years old to 14 years old each 20ml, 3 times on the one.Its defective is that said preparation is a liquid preparation, and dosage form falls behind; The poor stability of oral solutions; Contain antiseptic and a large amount of sucrose, some patient can produce untoward reaction, influences the safety of preparation; Oral solutions carries inconvenience; Oral formulations production equipment, process conditions require high, and cost is higher.Therefore, the exploitation preparation stabilization, drug safety, dosage is accurate, quality controllable, the reliable Chinese medicine preparation of curative effect is significant.
Summary of the invention
Technical problem to be solved by this invention is at the deficiencies in the prior art, and a kind of dosage form novelty, preparation stabilization, drug safety, dosage is accurate, quality controllable, curative effect is treated the infantile lung heat cough with asthma reliably medicine are provided.
The present invention also provides the preparation method of this kind medicine.
Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of medicine for the treatment of the infantile lung heat cough with asthma, is characterized in, it is by the made medicament of following weight percentages, and its dosage form is an effervescent tablet,
Herbal raw material,
Herba Ephedrae 1.5-3.5% Semen Armeniacae Amarum 4.0-6.0% Gypsum Fibrosum 18-25%
Radix Glycyrrhizae 1.5-3.5% Flos Lonicerae 6-12% Fructus Forsythiae 6-12%
Rhizoma Anemarrhenae 6-12% Radix Scutellariae 6-12% Radix Isatidis 6-12%
Radix Ophiopogonis 6-12% Herba Houttuyniae 6-12%
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 0.1-1.0%
Sodium bicarbonate 0.3-1.0% lactose 1.0-5.0%
Starch or the sweet 0.1-1.0% of dextrin 1.0-5.0% toffee.
Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of medicine for the treatment of the infantile lung heat cough with asthma is characterized in, the percentage by weight of each raw material is,
Herbal raw material:
Herba Ephedrae 2.6% Semen Armeniacae Amarum 5.2% Gypsum Fibrosum 21.0%
Radix Glycyrrhizae 2.6% Flos Lonicerae 8.8% Fructus Forsythiae 8.8%
The Rhizoma Anemarrhenae 8.8% Radix Scutellariae 8.8% Radix Isatidis 8.8%
Radix Ophiopogonis 8.8% Herba Houttuyniae 8.8%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 0.2%
Sodium bicarbonate 0.6% lactose 3.0%
Starch or dextrin 3.0% toffee sweet 0.2%.
Technical problem to be solved by this invention can also further realize by following technical scheme.The present invention is a kind of preparation method for the treatment of the medicine of infantile lung heat cough with asthma, is characterized in, gets described 11 kinds of herbal raw materials, decoct with water 2-4 time, each 1-3 hour, collecting decoction, filter, filtrate is concentrated into and records its relative density at 90～95 ℃ is 1.12～1.14, room temperature to be chilled to, add ethanol and make and contain alcohol amount and reach 70-90%, stir evenly, left standstill 6-18 hour, filter, filtrate recycling ethanol, being concentrated into and recording its relative density at 90～95 ℃ is 1.22～1.24, spray drying, powder gets dry extract; Dried cream powder adds lactose, starch or dextrin, toffee is sweet, is divided into two parts again and makes granule with citric acid or fumaric acid or malic acid, sodium bicarbonate respectively, and drying is mixed, compacting in flakes, infantile lung heat cough with asthma effervescent tablet gets product.Technical problem to be solved by this invention can also realize by following technical scheme.
The preparation method of the medicine that the above-described a kind of children's's of treatment the bottom of heart heat syndrome cough is breathed heavily is characterized in that the contained ephedrine of finished product infantile lung heat cough with asthma effervescent tablet is pressed ephedrine hydrochloride C
10H
15The NOHCI meter, every is no less than 1.5 milligrams.
The inspection of medicine effervescent tablet of the present invention (this product) is as follows:
(1) get this product 3g, add 25% sodium hydroxide solution 2ml, the 30ml jolting that adds diethyl ether is extracted, and divides and gets ether solution, and low temperature evaporate to dryness, residue add ethanol 2ml makes dissolving, as need testing solution.Other gets the ephedrine hydrochloride reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw above-mentioned two kinds of each 5ul of solution, put respectively in same and contain on the silica gel g thin-layer plate that sodium carboxymethyl cellulose is a binding agent, with alcohol-water-chloroform-ammonia (10: 4: 1: 0.5) be developing solvent, launch, take out airing, spray is with 0.2% ethanol solution of ninhydrin, and it is clear that hot blast blows to the speckle colour developing.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(2) get this product 1.0g, add dehydrated alcohol 25ml, behind the shake well, get supernatant as need testing solution.Other gets Radix Scutellariae glycoside reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw above-mentioned two kinds of each 10ul of solution, put respectively on the synthetic silica gel g thin-layer plate of same usefulness 4% sodium acetate, with ethyl acetate-butanone-methanol-water (5: 3: 1: 1) be developing solvent, launch, take out, airing, spray is with 2% ferric chloride alcoholic solution.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(3) get this product 0.5g, use chloroform extraction 2 times, each 30ml, discard chloroform layer, water layer is with water saturated n-butanol extraction 2 times, each 20ml, merge just in alcohol extract, add hydrochloric acid 2ml, reflux 1 hour, the saturated water washing of n-butyl alcohol 2 times of n-butyl alcohol liquid, each 50ml discards water layer, n-butyl alcohol liquid evaporate to dryness, the residue 10ml that adds diethyl ether makes dissolving, ether solution is added on the neutral alumina post of having handled well (100～120 order), 5g, internal diameter 10mm, (with the prewashing of preceding usefulness 10ml ether), with ether 10ml eluting, collect eluent, put evaporate to dryness in the water-bath, residue adds ethanol 1ml makes dissolving, as need testing solution.Other gets the chinaroot greenbrier sapogenin reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000), draw above-mentioned two kinds of each 2ul of solution, put respectively on same silica gel g thin-layer plate, with benzene-acetone (9: 1) is developing solvent, launch, take out airing, spray is with the mixed liquor (5: 1) of 8% vanillin ethanol solution and sulfuric acid solution (7 → 10), and it is clear that hot blast blows to the speckle colour developing.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(4) get this product 2g and add 2ml hydrochloric acid, with the 30ml chloroform ultrasonic (250W, 40KHZ) 1 hour, filter, filtrate water bath method, residue add the 1ml anhydrous alcohol solution, as need testing solution.Extracting liquorice subacid reference substance adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution in addition.According to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2000) test, draw above-mentioned two kinds of each 10ul of solution, put in same silica gel G F respectively
254On the lamellae, (10: 20: 7: 0.5) be developing solvent, expansion was taken out, and airing is observed under ultra-violet lamp 254nm with petroleum ether-benzene-ethyl acetate-glacial acetic acid.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
Content of medicines of the present invention is measured as follows:
Chromatographic condition and system suitability test: use octadecylsilane chemically bonded silica as filler; With acetonitrile-water-phosphoric acid (15: 85: 0.1) is mobile phase; The detection wavelength is 210nm.Number of theoretical plate is pressed the ephedrine hydrochloride peak and is calculated, and should be not less than 4000.
The preparation of reference substance solution: it is an amount of to get the ephedrine hydrochloride reference substance, and accurate the title decides, and adds methanol and makes the solution that every 1ml contains 30 μ g, promptly.
The preparation of need testing solution: get the content under the content uniformity item, porphyrize is got about 2g, the accurate title, decide, and puts in the apparatus,Soxhlet's, adds strong ammonia solution 3ml, ethanol 10ml and ether 120ml, placed 12 hours, add diethyl ether and put in the water-bath reflux 4 hours, extracting solution is put in the evaporating dish, and container washs with a small amount of ether, washing liquid merges, evaporate to dryness ether, residue add dissolve with methanol and are settled to 25ml, as need testing solution.
Algoscopy: accurate respectively reference substance solution and the need testing solution 10 μ l of drawing, inject chromatograph of liquid, measure, promptly.
Compared with prior art, the dosage form of medicine of the present invention adopts novel effervescent tablet, good mouthfeel when taking, and solution overall appearance sensation is graceful, and similar soda pop is easy to child patient and accepts; The present invention adopts spray drying method in preparation technology on the basis of a large amount of experiments, shortened drying time, and spray powder can directly be granulated, and saves and pulverizes this operation, has shortened technological process greatly, reduce cost, reduced the possibility of polluting once more in the crushing process; Effervescent tablet of the present invention is a solid preparation, good stability, and easily storage is convenient for carrying; Medicine of the present invention does not contain antiseptic; Preparation of the present invention rises to high performance liquid chromatography with the thin layer chromatography scanning in the former content assaying method on the basis of proper mass standard, improved assay precision and accuracy, thereby can control drug quality better, guarantees the curative effect of medicine.
Medicine of the present invention is that pale brown color is to tan or xanchromatic Film coated tablets; It is sweet to distinguish the flavor of, little hardship.Function cures mainly: heat-clearing and toxic substances removing, dispersing lung-QI and dissipating phlegm.Be used for pathogenic heat violate in lung defend due to fever and sweating, micro evil wind is cold, cough, expectorant Huang, or double panting, xerostomia and wait disease yearningly.Usage and dosage: get this product and put in an amount of eliminating cold for resuscitation water, wait to dissolve the back oral, 1 years old to 3 years old each 1,3 times on the one; 4 years old to 7 years old each 1,4 times on the one; 8 years old to 14 years old each 2,3 times on the one.Or follow the doctor's advice.
The specific embodiment
Embodiment 1.A kind of medicine for the treatment of the infantile lung heat cough with asthma, it is by the made medicament of following weight percentages, its dosage form is an effervescent tablet,
Herbal raw material:
Herba Ephedrae 2.6% Semen Armeniacae Amarum 5.2% Gypsum Fibrosum 21.0%
Radix Glycyrrhizae 2.6% Flos Lonicerae 8.8% Fructus Forsythiae 8.8%
The Rhizoma Anemarrhenae 8.8% Radix Scutellariae 8.8% Radix Isatidis 8.8%
Radix Ophiopogonis 8.8% Herba Houttuyniae 8.8%;
Pharmaceutic adjuvant:
Citric acid 0.2%
Sodium bicarbonate 0.6% lactose 3.0%
Starch 3.0% toffee sweet 0.2%
Embodiment 2.Embodiment 1 described a kind of preparation method for the treatment of the medicine of infantile lung heat cough with asthma is got described 11 kinds of herbal raw materials, decocts with water 3 times, each 3 hours, collecting decoction filtered, filtrate is concentrated into and records its relative density at 92 ℃ is 1.13, and room temperature to be chilled to adds ethanol and makes and contain alcohol amount and reach 80%, stir evenly, left standstill 12 hours, filter, filtrate recycling ethanol, being concentrated into and recording its relative density at 92 ℃ is 1.23, spray drying, and powder gets dry extract; It is sweet that dried cream powder adds lactose, starch, toffee, is divided into two parts again and makes granule with citric acid, sodium bicarbonate respectively, and drying is mixed, compacting in flakes, infantile lung heat cough with asthma effervescent tablet gets product.
Embodiment 3.A kind of medicine for the treatment of the infantile lung heat cough with asthma, it is by the made medicament of following weight percentages, its dosage form is an effervescent tablet,
Herbal raw material,
Herba Ephedrae 3.5% Semen Armeniacae Amarum 6.0% Gypsum Fibrosum 25%
Radix Glycyrrhizae 3.5% Flos Lonicerae 7% Fructus Forsythiae 7%
The Rhizoma Anemarrhenae 7% Radix Scutellariae 7% Radix Isatidis 7%
Radix Ophiopogonis 7% Herba Houttuyniae 7%;
Pharmaceutic adjuvant:
Fumaric acid 1%
Sodium bicarbonate 1% lactose 5%
Dextrin 5% toffee sweet 1%.
Embodiment 4.Embodiment 3 described a kind of preparation methoies for the treatment of the medicine of infantile lung heat cough with asthma are got described 11 kinds of herbal raw materials, decoct with water 2 times, each 2 hours, collecting decoction filtered, filtrate is concentrated into and records its relative density at 95 ℃ is 1.12, and room temperature to be chilled to adds ethanol and makes and contain alcohol amount and reach 90%, stir evenly, left standstill 18 hours, filter, filtrate recycling ethanol, being concentrated into and recording its relative density at 95 ℃ is 1.23, spray drying, and powder gets dry extract; It is sweet that dried cream powder adds lactose, dextrin, toffee, is divided into two parts again and makes granule with fumaric acid, sodium bicarbonate respectively, and drying is mixed, compacting in flakes, infantile lung heat cough with asthma effervescent tablet gets product.
Embodiment 5.A kind of medicine for the treatment of the infantile lung heat cough with asthma, it is by the made medicament of following weight percentages, its dosage form is an effervescent tablet,
Herbal raw material,
Herba Ephedrae 1.5% Semen Armeniacae Amarum 4.0% Gypsum Fibrosum 18%
Radix Glycyrrhizae 1.5% Flos Lonicerae 8% Fructus Forsythiae 10%
The Rhizoma Anemarrhenae 11% Radix Scutellariae 12% Radix Isatidis 11%
Radix Ophiopogonis 8% Herba Houttuyniae 12%;
Pharmaceutic adjuvant:
Malic acid 0.1%
Sodium bicarbonate 0.3% lactose 1.0%
Starch 1.5% toffee sweet 0.1%.
Embodiment 6.Embodiment 5 described a kind of preparation methoies for the treatment of the medicine of infantile lung heat cough with asthma are got described 11 kinds of herbal raw materials, decoct with water 4 times, preceding 2 times each 3 hours, back 2 times each 1 hour, collecting decoction, filter, filtrate is concentrated into and records its relative density at 90 ℃ is 1.14, room temperature to be chilled to, add ethanol and make and contain alcohol amount and reach 70%, stir evenly, left standstill 6 hours, filter, filtrate recycling ethanol, being concentrated into and recording its relative density at 90 ℃ is 1.24, spray drying, powder gets dry extract; It is sweet that dried cream powder adds lactose, starch, toffee, is divided into two parts again and makes granule with malic acid, sodium bicarbonate respectively, and drying is mixed, compacting in flakes, infantile lung heat cough with asthma effervescent tablet gets product.
Embodiment 7.A kind of medicine for the treatment of the infantile lung heat cough with asthma, it is by the made medicament of following weight percentages, its dosage form is an effervescent tablet,
Herbal raw material,
Herba Ephedrae 2% Semen Armeniacae Amarum 4.5% Gypsum Fibrosum 23%
Radix Glycyrrhizae 2% Flos Lonicerae 10% Fructus Forsythiae 8%
The Rhizoma Anemarrhenae 10% Radix Scutellariae 9% Radix Isatidis 8%
Radix Ophiopogonis 8% Herba Houttuyniae 8%;
Pharmaceutic adjuvant:
Citric acid 0.5%
Sodium bicarbonate 0.6% lactose 3.4%
Dextrin 2.5% toffee sweet 0.5%.
Its preparation method is, gets above-mentioned 11 kinds of herbal raw materials, decocts with water 3 times, each 2 hours, collecting decoction filtered, filtrate is concentrated into and records its relative density at 93 ℃ is 1.13, and room temperature to be chilled to adds ethanol and makes and contain alcohol amount and reach 85%, stir evenly, left standstill 15 hours, filter, filtrate recycling ethanol, being concentrated into and recording its relative density at 93 ℃ is 1.22, spray drying, and powder gets dry extract; It is sweet that dried cream powder adds lactose, dextrin, toffee, is divided into two parts again and makes granule with citric acid, sodium bicarbonate respectively, and drying is mixed, compacting in flakes, infantile lung heat cough with asthma effervescent tablet gets product.
Embodiment 8.A kind of medicine for the treatment of the infantile lung heat cough with asthma, it is by the made medicament of the raw material of following weight, its dosage form is an effervescent tablet, (unit: gram)
Herbal raw material,
Herba Ephedrae 500 Semen Armeniacae Amarums 1000 Gypsum Fibrosum 4000
Radix Glycyrrhizae 500 Flos Loniceraes 1666 Fructus Forsythiaes 1666
The Rhizoma Anemarrhenae 1666 Radix Scutellariaes 1666 Radix Isatidiss 1666
Radix Ophiopogonis 1666 Herba Houttuyniae 1666
Pharmaceutic adjuvant:
Citric acid 42 sodium bicarbonate 126 lactose 566
Soluble starch 566 toffees sweet 50.
Its preparation method is, gets described 11 kinds of herbal raw materials, decocts with water 3 times, the 1st time 3 hours, all the other each 1 hour, collecting decoction, filter, filtrate is concentrated into and records its relative density at 95 ℃ is 1.12, room temperature to be chilled to, add ethanol and make and contain alcohol amount and reach 80%, stir evenly, left standstill 12 hours, filter, filtrate recycling ethanol, being concentrated into and recording its relative density at 95 ℃ is 1.24, spray drying, powder gets dry extract; It is sweet that dried cream powder adds lactose, soluble starch, toffee, is divided into two parts again and makes granule with citric acid, sodium bicarbonate respectively, and drying is mixed, compacting in flakes, infantile lung heat cough with asthma effervescent tablet gets product.On inspection, the contained ephedrine of finished product infantile lung heat cough with asthma effervescent tablet is pressed ephedrine hydrochloride C
10H
15The NOHCI meter, every is 1.55 milligrams.
Claims (4)
1, a kind of medicine for the treatment of the infantile lung heat cough with asthma is characterized in that, it is by the made medicament of following weight percentages, and its dosage form is an effervescent tablet,
Herbal raw material,
Herba Ephedrae 1.5-3.5% Semen Armeniacae Amarum 4.0-6.0% Gypsum Fibrosum 18-25%
Radix Glycyrrhizae 1.5-3.5% Flos Lonicerae 6-12% Fructus Forsythiae 6-12%
Rhizoma Anemarrhenae 6-12% Radix Scutellariae 6-12% Radix Isatidis 6-12%
Radix Ophiopogonis 6-12% Herba Houttuyniae 6-12%
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 0.1-1.0%
Sodium bicarbonate 0.3-1.0% lactose 1.0-5.0%
Starch or the sweet 0.1-1.0% of dextrin 1.0-5.0% toffee.
2, a kind of medicine for the treatment of the infantile lung heat cough with asthma according to claim 1 is characterized in that, the percentage by weight of each raw material is,
Herbal raw material:
Herba Ephedrae 2.6% Semen Armeniacae Amarum 5.2% Gypsum Fibrosum 21.0%
Radix Glycyrrhizae 2.6% Flos Lonicerae 8.8% Fructus Forsythiae 8.8%
The Rhizoma Anemarrhenae 8.8% Radix Scutellariae 8.8% Radix Isatidis 8.8%
Radix Ophiopogonis 8.8% Herba Houttuyniae 8.8%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 0.2%
Sodium bicarbonate 0.6% lactose 3.0%
Starch or dextrin 3.0% toffee sweet 0.2%.
3, claim 1 or 2 described a kind of preparation methoies for the treatment of the medicine of infantile lung heat cough with asthma, it is characterized in that, get described 11 kinds of herbal raw materials, decoct with water 2-4 time, each 1-3 hour, collecting decoction filtered, filtrate is concentrated into and records its relative density at 90～95 ℃ is 1.12～1.14, room temperature to be chilled to adds ethanol and makes and contain alcohol amount and reach 70-90%, stirs evenly, left standstill 6-18 hour, filter, filtrate recycling ethanol, being concentrated into and recording its relative density at 90～95 ℃ is 1.22～1.24, spray drying, powder gets dry extract; Dried cream powder adds lactose, starch or dextrin, toffee is sweet, is divided into two parts again and makes granule with citric acid or fumaric acid or malic acid, sodium bicarbonate respectively, and drying is mixed, compacting in flakes, infantile lung heat cough with asthma effervescent tablet gets product.
4, the preparation method of the medicine breathed heavily of a kind of children's's of treatment the bottom of heart heat syndrome cough according to claim 3 is characterized in that the contained ephedrine of finished product infantile lung heat cough with asthma effervescent tablet is pressed ephedrine hydrochloride C
10H
15The NOHCI meter, every is no less than 1.5 milligrams.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100141824A CN1559524A (en) | 2004-02-25 | 2004-02-25 | Medicine for treating child cough and dyspnea due to the lung-heat and its preparaton method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100141824A CN1559524A (en) | 2004-02-25 | 2004-02-25 | Medicine for treating child cough and dyspnea due to the lung-heat and its preparaton method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1559524A true CN1559524A (en) | 2005-01-05 |
Family
ID=34440243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100141824A Pending CN1559524A (en) | 2004-02-25 | 2004-02-25 | Medicine for treating child cough and dyspnea due to the lung-heat and its preparaton method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1559524A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569712B (en) * | 2009-03-04 | 2012-07-11 | 北京师范大学 | Chinese traditional medicine composition for treating cold |
| CN101530570B (en) * | 2008-03-12 | 2012-07-25 | 陈爱中 | Medicine for treating respiratory disease |
| CN101708275B (en) * | 2009-11-27 | 2012-11-28 | 北京市卫生局临床药学研究所 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
| CN105232911A (en) * | 2015-10-12 | 2016-01-13 | 菏泽高新区尊桂堂科技有限公司 | Traditional Chinese medicine composition |
| CN105998984A (en) * | 2016-08-01 | 2016-10-12 | 毛德西 | Traditional Chinese medicine for treating children with lung heat type cough and asthma |
| CN113834883A (en) * | 2021-06-22 | 2021-12-24 | 海南葫芦娃药业集团股份有限公司 | Method for determining content of fructus forsythiae in infantile lung heat cough and asthma granules |
-
2004
- 2004-02-25 CN CNA2004100141824A patent/CN1559524A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530570B (en) * | 2008-03-12 | 2012-07-25 | 陈爱中 | Medicine for treating respiratory disease |
| CN101569712B (en) * | 2009-03-04 | 2012-07-11 | 北京师范大学 | Chinese traditional medicine composition for treating cold |
| CN101708275B (en) * | 2009-11-27 | 2012-11-28 | 北京市卫生局临床药学研究所 | Chinese medicament for treating flu caused by influenza A(H1N1) and the like |
| CN105232911A (en) * | 2015-10-12 | 2016-01-13 | 菏泽高新区尊桂堂科技有限公司 | Traditional Chinese medicine composition |
| CN105232911B (en) * | 2015-10-12 | 2019-05-03 | 杨立国 | A kind of Chinese medicine composition |
| CN105998984A (en) * | 2016-08-01 | 2016-10-12 | 毛德西 | Traditional Chinese medicine for treating children with lung heat type cough and asthma |
| CN113834883A (en) * | 2021-06-22 | 2021-12-24 | 海南葫芦娃药业集团股份有限公司 | Method for determining content of fructus forsythiae in infantile lung heat cough and asthma granules |
| CN113834883B (en) * | 2021-06-22 | 2023-05-26 | 海南葫芦娃药业集团股份有限公司 | Method for measuring content of forsythin in children's lung heat cough and asthma granule |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101057878A (en) | Pomegranate rind extraction and its preparation method | |
| CN1806846A (en) | Chinese medicinal composition, its preparation process and quality control method | |
| CN1762465A (en) | Rhinitis gel, its preparation method and quality control technology | |
| CN1814157A (en) | Chinese medicine preparation for detoxicating and pain-relieving, preparation method and quality control method | |
| CN101057925A (en) | Preparation technology for 'jieguqili' capsule and its quality control method | |
| CN100342847C (en) | Stomach nourishing dispersible tablet with aucklandia root and amomum fruit and its preparation method | |
| CN1301103C (en) | Kelu drip pill used for phlegm transforming cough suppressing and its preparation method | |
| CN1559524A (en) | Medicine for treating child cough and dyspnea due to the lung-heat and its preparaton method | |
| CN1813860A (en) | Naoxinqing Chinese medicine dispersible tablet and its preparing process | |
| CN100346820C (en) | Jindilan detoxin medicinal composition, preparation and its preparation method | |
| CN1226033C (en) | Method for preparing traditional Chinese medicine concentrated pill | |
| CN101028348A (en) | Chinese medicinal capsule, its production and quality controlling method | |
| CN1887324A (en) | Chinese composition and its prepn process and quality control method | |
| CN1879850A (en) | Capsule with hairy vein agrimony and arenobufagin, its preparation process and quality control method | |
| CN1887328A (en) | Chinese medicine composition and its prepn process and quality control method | |
| CN1803178A (en) | Traditional Chinese medicine composition and its preparation method and quality control method | |
| CN1872202A (en) | Method for preparing medication of replenishing qi and the blood | |
| CN1850132A (en) | Herba thesii granules and preparing method therefor | |
| CN1323676C (en) | Method for preparing traditional Chinese medicine capsule for treating weakness of spleen and stomach, and its quality control method | |
| CN1879849A (en) | Compound capsule with pseudo-ginseng and Chinese fanpalm seed, its preparation process and quality control method | |
| CN1559527A (en) | Compound stemona cough stopping medicine and its preparation method | |
| CN1559525A (en) | Red tangerine peel medicine for treating sputum cough and its preparation method | |
| CN1846730A (en) | Chaihuang soft capsule preparing process and its quality control technology | |
| CN1931337A (en) | Bock greenbrier rhizome micro pill and its prepn process | |
| CN1814007A (en) | Yankening medicine preparation and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |