CN1559525A - Red tangerine peel medicine for treating sputum cough and its preparation method - Google Patents
Red tangerine peel medicine for treating sputum cough and its preparation method Download PDFInfo
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- CN1559525A CN1559525A CNA2004100141839A CN200410014183A CN1559525A CN 1559525 A CN1559525 A CN 1559525A CN A2004100141839 A CNA2004100141839 A CN A2004100141839A CN 200410014183 A CN200410014183 A CN 200410014183A CN 1559525 A CN1559525 A CN 1559525A
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- Prior art keywords
- juhong tanke
- adds
- semen armeniacae
- armeniacae amarum
- medicine
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- 239000003814 drug Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims description 23
- 206010011224 Cough Diseases 0.000 title abstract description 4
- 206010036790 Productive cough Diseases 0.000 title abstract description 3
- 208000024794 sputum Diseases 0.000 title abstract 2
- 210000003802 sputum Anatomy 0.000 title abstract 2
- 241000675108 Citrus tangerina Species 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 94
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 51
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 31
- 239000008187 granular material Substances 0.000 claims description 30
- 239000000047 product Substances 0.000 claims description 29
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 28
- 210000000582 semen Anatomy 0.000 claims description 26
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 25
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 25
- 239000000843 powder Substances 0.000 claims description 24
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 23
- 229960004756 ethanol Drugs 0.000 claims description 22
- 239000000706 filtrate Substances 0.000 claims description 22
- 239000008361 herbal raw material Substances 0.000 claims description 22
- 238000001035 drying Methods 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 20
- 239000000341 volatile oil Substances 0.000 claims description 20
- 239000000796 flavoring agent Substances 0.000 claims description 16
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 16
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 15
- 235000012907 honey Nutrition 0.000 claims description 15
- 239000007921 spray Substances 0.000 claims description 15
- 239000001530 fumaric acid Substances 0.000 claims description 14
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 14
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 11
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 11
- 239000001630 malic acid Substances 0.000 claims description 11
- 235000011090 malic acid Nutrition 0.000 claims description 11
- 229920002472 Starch Polymers 0.000 claims description 10
- 230000006837 decompression Effects 0.000 claims description 10
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 10
- 238000004821 distillation Methods 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 238000004064 recycling Methods 0.000 claims description 10
- 239000008107 starch Substances 0.000 claims description 10
- 235000019698 starch Nutrition 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 10
- 238000001291 vacuum drying Methods 0.000 claims description 10
- 235000019634 flavors Nutrition 0.000 claims description 9
- 229920001353 Dextrin Polymers 0.000 claims description 8
- 239000004375 Dextrin Substances 0.000 claims description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 8
- 235000019425 dextrin Nutrition 0.000 claims description 8
- 239000008101 lactose Substances 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 6
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 claims description 4
- ATWHGWYKSFRYBN-UHFFFAOYSA-N Amygdaloside Natural products O1C(=O)C2(C)CCCC(C3CC4)(C)C2C1OCC3(C1)CC4C1(O)COC1OC(CO)C(O)C(O)C1O ATWHGWYKSFRYBN-UHFFFAOYSA-N 0.000 claims description 4
- 229940109275 cyclamate Drugs 0.000 claims description 3
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000003643 water by type Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 9
- 244000144725 Amygdalus communis Species 0.000 abstract 1
- 235000001759 Citrus maxima Nutrition 0.000 abstract 1
- 244000276331 Citrus maxima Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 235000003893 Prunus dulcis var amara Nutrition 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 39
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
- 238000012360 testing method Methods 0.000 description 15
- 230000001276 controlling effect Effects 0.000 description 12
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 235000013355 food flavoring agent Nutrition 0.000 description 7
- 239000012085 test solution Substances 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
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- 238000004809 thin layer chromatography Methods 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 235000011114 ammonium hydroxide Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- ONBIUAZBGHXJDM-UHFFFAOYSA-J bismuth;potassium;tetraiodide Chemical compound [K+].[I-].[I-].[I-].[I-].[Bi+3] ONBIUAZBGHXJDM-UHFFFAOYSA-J 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- LGZXYFMMLRYXLK-UHFFFAOYSA-N mercury(2+);sulfide Chemical compound [S-2].[Hg+2] LGZXYFMMLRYXLK-UHFFFAOYSA-N 0.000 description 2
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- 241000167854 Bourreria succulenta Species 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- YEZWWUMWIFKEQM-UHFFFAOYSA-N O.OC.ClC(Cl)Cl.CCOC(C)=O Chemical compound O.OC.ClC(Cl)Cl.CCOC(C)=O YEZWWUMWIFKEQM-UHFFFAOYSA-N 0.000 description 1
- GSEMDSHDLFBDML-UHFFFAOYSA-N O.OC=O.CCOC(C)=O Chemical compound O.OC=O.CCOC(C)=O GSEMDSHDLFBDML-UHFFFAOYSA-N 0.000 description 1
- 241001522129 Pinellia Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000545442 Radix Species 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- SIHHLZPXQLFPMC-UHFFFAOYSA-N chloroform;methanol;hydrate Chemical compound O.OC.ClC(Cl)Cl SIHHLZPXQLFPMC-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 description 1
- 229940052490 naringin Drugs 0.000 description 1
- 229930019673 naringin Natural products 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000079 presaturation Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- CGFYHILWFSGVJS-UHFFFAOYSA-N silicic acid;trioxotungsten Chemical compound O[Si](O)(O)O.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1 CGFYHILWFSGVJS-UHFFFAOYSA-N 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of effervescent tablet for treating cough and resolving sputum is prepared from 8 Chinese-medicinal materials including pummelo peel, bitter almond, liquorice root, etc and 3 medicinal additives: citric acid, dicarbonate and polyethanediol.
Description
Technical field
The present invention relates to a kind of is the pharmaceutical preparation that raw material is made with the Chinese herbal medicine, particularly a kind of Juhong Tanke medicine; The invention still further relates to the preparation method of this medicine.
Background technology
In the prior art, the Juhong Tanke granule is a kind of Chinese patent medicine of classics.It makes granule by eight flavor Chinese herbal medicine such as Exocarpium Citri Grandis, the Radix Stemonae (processed with honey), Semen Armeniacae Amarum, Poria, Rhizoma pinelliae cordatae (system), Fructus Schisandrae Chinensis, Rhizoma Cynanchi Stauntonii and Radix Glycyrrhizae.This Juhong Tanke granule has to regulate the flow of vital energy and eliminates the phlegm, the effect of nourishing the lung to arrest cough, the abundant expectoration cough that be used to catch a cold, bronchitis, pharyngolaryngitis causes, the clinical treatment of symptoms such as asthma.But said preparation is a granule, and dosage form is comparatively backward, and the granule dose is big, and contains a large amount of sucrose, and the easy moisture absorption of granule, is prone to caking phenomenon in the storage process.
Summary of the invention
Technical problem to be solved by this invention is at the deficiencies in the prior art, proposes a kind of effective component content height, taking dose little, mouthfeel and all good Juhong Tanke medicines of outward appearance when taking.
The present invention also provides the preparation method of this medicine.
Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of Juhong Tanke medicine, is characterized in, it is the medicament of being made by following weight percentages, and described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Exocarpium Citri Grandis 40-50% processed with honey Radix Stemonae 3-6% Semen Armeniacae Amarum 12-18%
Poria 3-6% controlling the water circulation Rhizoma Pinelliae 3-6% Fructus Schisandrae Chinensis 2-4%
Rhizoma Cynanchi Stauntonii 5-10% Radix Glycyrrhizae 1-3%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 3-6% sodium bicarbonate 4-7%
Polyethylene glycol 6000 1-3%.
Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of Juhong Tanke medicine is characterized in that it can also add the pharmaceutic adjuvant of following percentage by weight,
Starch or dextrin 1-3% Icing Sugar or lactose 1-3%.
Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of Juhong Tanke medicine is characterized in, the percentage by weight of each raw material is,
Herbal raw material:
The Exocarpium Citri Grandis 46.5% processed with honey Radix Stemonae 4.7% Semen Armeniacae Amarum 15.5%
The Poria 4.7% controlling the water circulation Rhizoma Pinelliae 4.7% Fructus Schisandrae Chinensis 3%
Rhizoma Cynanchi Stauntonii 7.8% Radix Glycyrrhizae 1.5%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 4.7% sodium bicarbonate 5.4%
Polyethylene glycol 6000 1.5%.
Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of Juhong Tanke medicine is characterized in, the percentage by weight of each raw material is,
Herbal raw material:
The Exocarpium Citri Grandis 46% processed with honey Radix Stemonae 4.5% Semen Armeniacae Amarum 15%
The Poria 4.5% controlling the water circulation Rhizoma Pinelliae 4.5% Fructus Schisandrae Chinensis 3%
Rhizoma Cynanchi Stauntonii 7.5% Radix Glycyrrhizae 1.5%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 4% sodium bicarbonate 5%
Polyethylene glycol 6000 1.5%
Starch or dextrin 1.5% Icing Sugar or lactose 1.5%.
The invention also discloses a kind of preparation method of Juhong Tanke medicine, be characterized in, in the described 8 flavor herbal raw materials, get Exocarpium Citri Grandis, the Semen Armeniacae Amarum vapor distillation is collected volatile oil, medicinal residues and all the other Six-elements, decoct with water 1-3 time, filter, merging filtrate is concentrated into the thick paste shape, add ethanol, make it contain alcohol amount and reach 75-80%, leave standstill, get supernatant at-0.08--0.10MPa, decompression recycling ethanol under the 70-90 ℃ of condition, and be concentrated into and in the time of 50 ℃, record the clear paste that its relative density is 1.30-1.40, vacuum drying below 70 ℃ is ground into fine powder, adds citric acid or fumaric acid or malic acid, mix homogeneously, granulate with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule; drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of cyclamate, essence; can also add starch or dextrin, Icing Sugar or lactose simultaneously, compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
Technical problem to be solved by this invention can also further realize by following technical scheme.The preparation method of above-described a kind of Juhong Tanke medicine is characterized in, every finished product Juhong Tanke effervescent tablet contains Semen Armeniacae Amarum with amygdaloside C
20H
27NO
11Meter is not less than 25 milligrams.
Technical problem to be solved by this invention can also further realize by following technical scheme.The preparation method of above-described a kind of Juhong Tanke medicine is characterized in, gets 6 of finished product Juhong Tanke effervescent tablets, adds 15 ℃ 100 milliliters in water respectively, effervescent tablet disintegrate in 5 minutes.
Technical problem to be solved by this invention can also further realize by following technical scheme.The preparation method of above-described a kind of Juhong Tanke medicine is characterized in, gets 1 of finished product Juhong Tanke effervescent tablet, and porphyrize drops in 100 ml waters, and stirring and making its dissolving, its pH value is 4.0-5.5.
The discriminating of medicine of the present invention (hereinafter to be referred as this product) is as follows:
(1) get this product 5g, grind, add methanol 10ml, warmly make dissolving, filter, get filtrate 1-2ml, add magnesium powder a little, hydrochloric acid 4-5 drips, and is cherry red.
(2) get this product 10g, add petroleum ether 20ml, milling and extracting, leaching ether liquid volatilizes, and residue adds vanillin test solution 1-2 and drips, and puts in the water-bath and heats, and is aubergine.
(3) get this product 10g, add 0.5% ethanol solution hydrochloride 30ml, ground 5 minutes, warm, filter, filtrate transfers pH to neutral with ammonia solution, and water bath method, residue 5% sulfuric acid solution filters.Get filtrate 1ml, add bismuth potassium iodide test solution 1-2 and drip, generate the Chinese red precipitation; Get filtrate 1ml, add test solution of mercuric potassium iodide 1-2 and drip, generate white precipitate; Get filtrate 1ml, add silico-tungstic acid test solution 1-2 and drip, generate white precipitate.
(4) it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, with 20ml 80% methanol solution reflux, extract, 30min, puts coldly, filters, and gets filtrate as need testing solution.Other gets the naringin reference substance and makes 0.5mg/ml solution product solution in contrast with 80% dissolve with methanol solution in right amount.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G plate lamellae, upper strata liquid with ethyl acetate-formic acid-water (10: 2: 3) is developing solvent, launch, dry, spray is inspected under the ultraviolet 365nm with the aluminum chloride test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the fluorescence principal spot of same color.
(5) it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, with 30ml 0.5% hydrochloric acid solution supersound extraction 20min, filter, filtrate is regulated PH to 10-11 with strong ammonia solution, with chloroform extraction three times (15ml/ time), combined chloroform liquid, reclaim under reduced pressure to about 1ml as need testing solution.Other gets control medicinal material 2 grams, is ground into fine powder, with 30ml 0.5% hydrochloric acid solution supersound extraction 20min, filter, filtrate is regulated PH to 10-11 with strong ammonia solution, with chloroform extraction three times (15ml/ time), combined chloroform liquid, reclaim under reduced pressure is to about 1ml medical material solution in contrast.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G plate lamellae, with benzene-ethyl acetate-methanol-isopropyl alcohol-strong ammonia solution (12: 6: 3: 3: 1) is developing solvent, put with in 15 minutes the expansion cylinder of ammonia steam presaturation, launch, dry, spray develops the color with bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the Chinese red principal spot of same color.
(6) it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, adds water 20ml and makes dissolving, filters, and filtrate is with water saturated n-butanol extraction three times, and each 20ml merges butanol solution, and reclaim under reduced pressure is to doing, residue with the 5ml dissolve with methanol as need testing solution.It is an amount of that other gets the amygdaloside reference substance, makes about 2mg/ml solution product solution in contrast with dissolve with methanol.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G plate lamellae, (15: 40: 22: 10) 10 ℃ of subnatants of placing 12 hours were developing solvent with chloroform-ethyl acetate-methanol-water, launch, dry, spray is with the phosphomolybdic acid sulfuric acid solution, and 105 ℃ of heating developed the color in 10 minutes.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the principal spot of same color.
(7) it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, adds saturated sodium bicarbonate aqueous solution 30ml and makes dissolving, filter, filtrate is with ethyl acetate extraction three times, each 20ml, combined ethyl acetate liquid, reclaim under reduced pressure is to doing, residue with the 1ml dissolve with methanol as need testing solution.Other gets Rhizoma Cynanchi Stauntonii control medicinal material 2g, adds sodium bicarbonate aqueous solution 30ml supersound process 30 minutes, filters, and gets filtrate and shines medical material solution in pairs with legal system.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same 0.5% sodium hydroxide silica gel G plate, with chloroform-methanol-water (2: 1: 1.5) is developing solvent, launch, dry, spray is with 25% phosphomolybdic acid ethanol solution, and room temperature is placed colour developing in 5-10 minute.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the principal spot of same color.
(8) it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, adds 10ml 80% methanol solution reflux, extract, 30min, puts coldly, filters, get filtrate wave to 0.5ml as need testing solution.Other gets Rhizoma Pinelliae control medicinal material 1g and adds 80% methanol solution 10ml and shine medical material solution in pairs with legal system.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B) test, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G plate, with n-butyl alcohol-glacial acetic acid-water (8: 3: 1) is developing solvent, launches, and dries, spray is with ninhydrin solution, and 105 ℃ of heating developed the color in 10 minutes.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the principal spot of same color.
The present invention compared with prior art has the following advantages: the dosage form of Juhong Tanke medicine of the present invention is an effervescent tablet, its dosage form advanced person; And with the effervescent tablet preparation stabilization of method of the present invention preparation, drug safety, dosage is accurate, quality controllable, curative effect is reliable, effective component content is high; Drug administration amount of the present invention is less relatively; Juhong Tanke effervescent tablet good mouthfeel of the present invention, and solution overall appearance sensation is graceful, and similar soda pop is easy to child patient and accepts.
The specific embodiment
Embodiment 1.A kind of Juhong Tanke medicine, it is the medicament of being made by the raw material of following weight, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material (unit: gram):
The Exocarpium Citri Grandis 300 processed with honey Radixs Stemonae 30 Semen Armeniacae Amarums 100
The Poria 30 controlling the water circulation Rhizoma Pinelliaes 30 Fructus Schisandrae Chinensis 20
Rhizoma Cynanchi Stauntonii 50 Radix Glycyrrhizaes 10;
Pharmaceutic adjuvant:
Citric acid 30 polyethylene glycol 6000s 10 sodium bicarbonate 35.
Embodiment 2.The preparation method of embodiment 1 described a kind of Juhong Tanke medicine in the described 8 flavor herbal raw materials, is got Exocarpium Citri Grandis, the Semen Armeniacae Amarum vapor distillation, collect volatile oil, Six-elements such as the medicinal residues and the controlling the water circulation Rhizoma Pinelliae decoct with water 2 times, filter, merging filtrate, be concentrated into the thick paste shape, add ethanol, make to contain the alcohol amount and reach 80%, leave standstill, get supernatant at-0.09MPa, decompression recycling ethanol under 80 ℃ of conditions, and be concentrated into that to record its relative density in the time of 50 ℃ be 1.35 clear paste, vacuum drying below 70 ℃, be ground into fine powder, add the citric acid fine powder, mix homogeneously is granulated with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying; Get above-mentioned two kinds of granule mix homogeneously, add an amount of cyclamate, essence, be pressed into 100 promptly.
Embodiment 3.A kind of Juhong Tanke medicine, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The Exocarpium Citri Grandis 40% processed with honey Radix Stemonae 6% Semen Armeniacae Amarum 17%
The Poria 6% controlling the water circulation Rhizoma Pinelliae 6% Fructus Schisandrae Chinensis 4%
Rhizoma Cynanchi Stauntonii 8% Radix Glycyrrhizae 2%;
Pharmaceutic adjuvant:
Fumaric acid 3% polyethylene glycol 6000 2% sodium bicarbonate 6%.
Embodiment 4.The preparation method of embodiment 3 described a kind of Juhong Tanke medicines in the described 8 flavor herbal raw materials, is got Exocarpium Citri Grandis, the Semen Armeniacae Amarum vapor distillation, collect volatile oil, medicinal residues and all the other Six-elements decoct with water 3 times, filter, merging filtrate, be concentrated into the thick paste shape, add ethanol, make it contain the alcohol amount and reach 75%, leave standstill, get supernatant at-0.08MPa, decompression recycling ethanol under 75 ℃ of conditions, and be concentrated into that to record its relative density in the time of 50 ℃ be 1.30 clear paste, vacuum drying below 70 ℃, be ground into fine powder, add the fumaric acid fine powder, mix homogeneously is granulated with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, and drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of sweeting agent, flavouring agent, and compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
Embodiment 5.A kind of Juhong Tanke medicine, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The Exocarpium Citri Grandis 46.5% processed with honey Radix Stemonae 4.7% Semen Armeniacae Amarum 15.5%
The Poria 4.7% controlling the water circulation Rhizoma Pinelliae 4.7% Fructus Schisandrae Chinensis 3%
Rhizoma Cynanchi Stauntonii 7.8% Radix Glycyrrhizae 1.5%;
Pharmaceutic adjuvant:
Malic acid 4.7% polyethylene glycol 6000 1.5% sodium bicarbonate 5.4%.
Its preparation method is in the described 8 flavor herbal raw materials, to get Exocarpium Citri Grandis, the Semen Armeniacae Amarum vapor distillation, collect volatile oil, medicinal residues and all the other Six-elements decoct with water 2 times, filter, merging filtrate, be concentrated into the thick paste shape, add ethanol, make it contain the alcohol amount and reach 78%, leave standstill, get supernatant at-0.10MPa, decompression recycling ethanol under 85 ℃ of conditions, and be concentrated into that to record its relative density in the time of 50 ℃ be 1.40 clear paste, vacuum drying below 70 ℃, be ground into fine powder, add the malic acid fine powder, mix homogeneously is granulated with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, and drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of sweeting agent, flavouring agent, and compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
Embodiment 6.Contain Semen Armeniacae Amarum with amygdaloside C according to embodiment 5 every prepared finished product Juhong Tanke effervescent tablets
20H
27NO
11Count 25 milligrams.
Embodiment 7.Get according to 6 of the prepared finished product Juhong Tanke effervescent tablets of embodiment 5, add 15 ℃ 100 milliliters in water respectively, effervescent tablet disintegrate in 5 minutes.
Embodiment 8.Get according to 1 of the prepared finished product Juhong Tanke effervescent of embodiment 5, porphyrize drops in 100 ml waters, and stirring and making its dissolving, its pH value is 5.
Embodiment 9.A kind of Juhong Tanke medicine, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The Exocarpium Citri Grandis 50% processed with honey Radix Stemonae 4% Semen Armeniacae Amarum 15%
The Poria 4% controlling the water circulation Rhizoma Pinelliae 4% Fructus Schisandrae Chinensis 4%
Rhizoma Cynanchi Stauntonii 8% Radix Glycyrrhizae 1%;
Pharmaceutic adjuvant:
Citric acid 5% polyethylene glycol 6000 1% sodium bicarbonate 4%.
Its preparation method is, get Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect volatile oil, medicinal residues and all the other Six-elements, decoct with water 3 times, filter, merging filtrate is concentrated into the thick paste shape, add ethanol, make it contain alcohol amount and reach 79%, leave standstill, get supernatant decompression recycling ethanol under-0.09MPa, 90 ℃ of conditions, and be concentrated into that to record its relative density in the time of 50 ℃ be 1.35 clear paste, vacuum drying below 70 ℃ is ground into fine powder, adds the citric acid fine powder, mix homogeneously, granulate with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, and drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of sweeting agent, flavouring agent, and compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
Embodiment 10.A kind of Juhong Tanke medicine, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The Exocarpium Citri Grandis 45% processed with honey Radix Stemonae 5% Semen Armeniacae Amarum 14%
The Poria 5% controlling the water circulation Rhizoma Pinelliae 5% Fructus Schisandrae Chinensis 2%
Rhizoma Cynanchi Stauntonii 5% Radix Glycyrrhizae 3%;
Pharmaceutic adjuvant:
Citric acid 6% polyethylene glycol 6000 3% sodium bicarbonate 7%;
Its preparation method is, get Exocarpium Citri Grandis, Semen Armeniacae Amarum vapor distillation, collect volatile oil, medicinal residues and all the other Six-elements, decoct with water 2 times, filter, merging filtrate is concentrated into the thick paste shape, add ethanol, make it contain alcohol amount and reach 80%, leave standstill, get supernatant decompression recycling ethanol under-0.09MPa, 80 ℃ of conditions, and be concentrated into that to record its relative density in the time of 50 ℃ be 1.38 clear paste, vacuum drying below 70 ℃ is ground into fine powder, adds the citric acid fine powder, mix homogeneously, granulate with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, and drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of sweeting agent, flavouring agent, and compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
Embodiment 11.A kind of Juhong Tanke medicine, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The Exocarpium Citri Grandis 45% processed with honey Radix Stemonae 5% Semen Armeniacae Amarum 14%
The Poria 5% controlling the water circulation Rhizoma Pinelliae 5% Fructus Schisandrae Chinensis 2%
Rhizoma Cynanchi Stauntonii 5% Radix Glycyrrhizae 3%;
Pharmaceutic adjuvant:
Citric acid 5% polyethylene glycol 6000 3% sodium bicarbonate 6%
Starch 1% lactose 1%.
Embodiment 12.The preparation method of embodiment 11 described a kind of Juhong Tanke medicines in the described 8 flavor herbal raw materials, is got Exocarpium Citri Grandis, the Semen Armeniacae Amarum vapor distillation, collect volatile oil, medicinal residues and all the other Six-elements decoct with water 3 times, filter, merging filtrate, be concentrated into the thick paste shape, add ethanol, make it contain the alcohol amount and reach 75%, leave standstill, get supernatant at-0.08MPa, decompression recycling ethanol under 75 ℃ of conditions, and be concentrated into that to record its relative density in the time of 50 ℃ be 1.30 clear paste, vacuum drying below 70 ℃, be ground into fine powder, add the fumaric acid fine powder, mix homogeneously is granulated with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, and drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of sweeting agent, flavouring agent, adds starch and lactose simultaneously, and compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
Embodiment 13.A kind of Juhong Tanke medicine, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The Exocarpium Citri Grandis 46% processed with honey Radix Stemonae 4.5% Semen Armeniacae Amarum 15%
The Poria 4.5% controlling the water circulation Rhizoma Pinelliae 4.5% Fructus Schisandrae Chinensis 3%
Rhizoma Cynanchi Stauntonii 7.5% Radix Glycyrrhizae 1.5%;
Pharmaceutic adjuvant:
Fumaric acid 4% sodium bicarbonate 5% big polyethylene glycol 6000 1.5%
Dextrin 1.5% Icing Sugar 1.5%.
Embodiment 14.The preparation method of embodiment 13 described a kind of Juhong Tanke medicines in the described 8 flavor herbal raw materials, is got Exocarpium Citri Grandis, the Semen Armeniacae Amarum vapor distillation, collect volatile oil, medicinal residues and all the other Six-elements decoct with water 3 times, filter, merging filtrate, be concentrated into the thick paste shape, add ethanol, make it contain the alcohol amount and reach 75%, leave standstill, get supernatant at-0.08MPa, decompression recycling ethanol under 75 ℃ of conditions, and be concentrated into that to record its relative density in the time of 50 ℃ be 1.30 clear paste, vacuum drying below 70 ℃, be ground into fine powder, add the fumaric acid fine powder, mix homogeneously is granulated with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, and drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of sweeting agent, flavouring agent, adds dextrin and Icing Sugar simultaneously, and compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
Embodiment 15.A kind of Juhong Tanke medicine, it is the medicament of being made by following weight percentages, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The Exocarpium Citri Grandis 40% processed with honey Radix Stemonae 4% Semen Armeniacae Amarum 14%
The Poria 4% controlling the water circulation Rhizoma Pinelliae 4% Fructus Schisandrae Chinensis 4%
Rhizoma Cynanchi Stauntonii 9% Radix Glycyrrhizae 1%;
Pharmaceutic adjuvant:
Malic acid 4% sodium bicarbonate 7%
Polyethylene glycol 6000 3%
Starch 3% Icing Sugar 3%.
Its preparation method is in the above-described 8 flavor herbal raw materials, to get Exocarpium Citri Grandis, the Semen Armeniacae Amarum vapor distillation, collect volatile oil, medicinal residues and all the other Six-elements decoct with water 3 times, filter, merging filtrate, be concentrated into the thick paste shape, add ethanol, make it contain the alcohol amount and reach 75%, leave standstill, get supernatant at-0.08MPa, decompression recycling ethanol under 75 ℃ of conditions, and be concentrated into that to record its relative density in the time of 50 ℃ be 1.30 clear paste, vacuum drying below 70 ℃, be ground into fine powder, add the fumaric acid fine powder, mix homogeneously is granulated with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, and drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of sweeting agent, flavouring agent, adds starch and Icing Sugar simultaneously, and compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
Claims (8)
1, a kind of Juhong Tanke medicine is characterized in that, it is the medicament of being made by following weight percentages, and described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Exocarpium Citri Grandis 4050% processed with honey Radix Stemonae 3-6% Semen Armeniacae Amarum 12-18%
Poria 3-6% controlling the water circulation Rhizoma Pinelliae 3-6% Fructus Schisandrae Chinensis 2-4%
Rhizoma Cynanchi Stauntonii 5-10% Radix Glycyrrhizae 1-3%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 3-6% sodium bicarbonate 4-7%
Polyethylene glycol 6000 1-3%.
2, a kind of Juhong Tanke medicine according to claim 1 is characterized in that it can also add the pharmaceutic adjuvant of following percentage by weight,
Starch or dextrin 1-3% Icing Sugar or lactose 1-3%.
3, a kind of Juhong Tanke medicine according to claim 1 is characterized in that, the percentage by weight of each raw material is,
Herbal raw material:
The Exocarpium Citri Grandis 46.5% processed with honey Radix Stemonae 4.7% Semen Armeniacae Amarum 15.5%
The Poria 4.7% controlling the water circulation Rhizoma Pinelliae 4.7% Fructus Schisandrae Chinensis 3%
Rhizoma Cynanchi Stauntonii 7.8% Radix Glycyrrhizae 1.5%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 4.7% sodium bicarbonate 5.4%
Polyethylene glycol 6000 1.5%.
4, a kind of Juhong Tanke medicine according to claim 2 is characterized in that, the percentage by weight of each raw material is,
Herbal raw material:
The Exocarpium Citri Grandis 46% processed with honey Radix Stemonae 4.5% Semen Armeniacae Amarum 15%
The Poria 4.5% controlling the water circulation Rhizoma Pinelliae 4.5% Fructus Schisandrae Chinensis 3%
Rhizoma Cynanchi Stauntonii 7.5% Radix Glycyrrhizae 1.5%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 4% sodium bicarbonate 5%
Polyethylene glycol 6000 1.5%
Starch or dextrin 1.5% Icing Sugar or lactose 1.5%.
5, the preparation method of any one described a kind of Juhong Tanke medicine of claim 1-4, it is characterized in that, in the described 8 flavor herbal raw materials, get Exocarpium Citri Grandis, the Semen Armeniacae Amarum vapor distillation is collected volatile oil, medicinal residues and all the other Six-elements, decoct with water 1-3 time, filter, merging filtrate is concentrated into the thick paste shape, add ethanol, make it contain alcohol amount and reach 75-80%, leave standstill, get supernatant at-0.08--0.10MPa, decompression recycling ethanol under the 70-90 ℃ of condition, and be concentrated into and in the time of 50 ℃, record the clear paste that its relative density is 1.30-1.40, vacuum drying below 70 ℃ is ground into fine powder, adds citric acid or fumaric acid or malic acid, mix homogeneously, granulate with dehydrated alcohol, spray adds Exocarpium Citri Grandis, Semen Armeniacae Amarum volatile oil, cold drying; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule; drying is got above-mentioned two kinds of granule mix homogeneously, adds an amount of cyclamate, essence; can also add starch or dextrin, Icing Sugar or lactose simultaneously, compacting is in blocks, and the Juhong Tanke effervescent tablet gets product.
6, the preparation method of a kind of Juhong Tanke medicine according to claim 5 is characterized in that, every finished product Juhong Tanke effervescent tablet contains Semen Armeniacae Amarum with amygdaloside C
20H
27NO
11Meter is not less than 25 milligrams.
7, the preparation method of a kind of Juhong Tanke medicine according to claim 5 is characterized in that, gets 6 of finished product Juhong Tanke effervescent tablets, adds 15 ℃ 100 milliliters in water respectively, effervescent tablet disintegrate in 5 minutes.
8, the preparation method of a kind of Juhong Tanke medicine according to claim 5 is characterized in that, gets 1 of finished product Juhong Tanke effervescent tablet, and porphyrize drops in 100 ml waters, and stirring and making its dissolving, its pH value is 4.0-5.5.
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| CNB2004100141839A CN1331522C (en) | 2004-02-25 | 2004-02-25 | Red tangerine peel medicine for treating sputum cough and its preparation method |
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| CNB2004100141839A CN1331522C (en) | 2004-02-25 | 2004-02-25 | Red tangerine peel medicine for treating sputum cough and its preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657362A (en) * | 2012-05-21 | 2012-09-12 | 广州中医药大学 | Method for improving mouthfeel of exocarpium citri grandis extract obviously and application of exocarpium citri grandis extract |
| CN102895379A (en) * | 2012-11-09 | 2013-01-30 | 挑战（天津）动物药业有限公司 | Pharmaceutical preparation for treating livestock respiratory diseases and method for preparing pharmaceutical preparation for treating livestock respiratory diseases |
| CN104034838A (en) * | 2013-03-07 | 2014-09-10 | 广西灵峰药业有限公司 | Quality detection method of Corsvenor Momordica Fruit cough-relieving syrup |
| CN105727104A (en) * | 2016-03-10 | 2016-07-06 | 广西天天乐药业股份有限公司 | Medicine composition with effects of diminishing inflammation and relieving cough and method for preparing medicine composition |
| CN106721864A (en) * | 2016-12-15 | 2017-05-31 | 广东石油化工学院 | A kind of clearing Exocarpium Citri Grandis effervescent tablet |
-
2004
- 2004-02-25 CN CNB2004100141839A patent/CN1331522C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657362A (en) * | 2012-05-21 | 2012-09-12 | 广州中医药大学 | Method for improving mouthfeel of exocarpium citri grandis extract obviously and application of exocarpium citri grandis extract |
| CN102895379A (en) * | 2012-11-09 | 2013-01-30 | 挑战（天津）动物药业有限公司 | Pharmaceutical preparation for treating livestock respiratory diseases and method for preparing pharmaceutical preparation for treating livestock respiratory diseases |
| CN104034838A (en) * | 2013-03-07 | 2014-09-10 | 广西灵峰药业有限公司 | Quality detection method of Corsvenor Momordica Fruit cough-relieving syrup |
| CN105727104A (en) * | 2016-03-10 | 2016-07-06 | 广西天天乐药业股份有限公司 | Medicine composition with effects of diminishing inflammation and relieving cough and method for preparing medicine composition |
| CN106721864A (en) * | 2016-12-15 | 2017-05-31 | 广东石油化工学院 | A kind of clearing Exocarpium Citri Grandis effervescent tablet |
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| CN1331522C (en) | 2007-08-15 |
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