CN1872202A - Method for preparing medication of replenishing qi and the blood - Google Patents
Method for preparing medication of replenishing qi and the blood Download PDFInfo
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- CN1872202A CN1872202A CNA200610011862XA CN200610011862A CN1872202A CN 1872202 A CN1872202 A CN 1872202A CN A200610011862X A CNA200610011862X A CN A200610011862XA CN 200610011862 A CN200610011862 A CN 200610011862A CN 1872202 A CN1872202 A CN 1872202A
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- pericarpium citri
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Abstract
A process for preparing the Chinese medicine to nourish qi and blood includes such steps as decocting the astragalus root and motherwort, filtering, concentrating to obtain extract A, pulverizing Chinese angelica root and tangerine peel, immersing in alcohol, seeping, concentrating to obtain extract B, dissolving donkey-hide gelatin in the extract A, mixing with extract B, adding additive and shaping.
Description
Technical field
The present invention relates to a kind of preparation method of benefiting vital QI and blood medicine.
Background technology
In the preparation method of Chinese medicine, when relating to Colla Corii Asini, generally be to be cut into fritter, join again in 60-80 ℃ of baking postcooling, after pulverizing in the powder or medicinal liquid that other crude drug make, its defective is: through baking and its contained animal colloid of Colla Corii Asini of pulverizing certain loss is arranged, can farthest keep its drug effect and among the present invention Colla Corii Asini directly is dissolved in the medicinal liquid.
In the preparation method of Chinese medicine, generally granulate adding adjuvant after the clear paste spray drying again, this moment must be with ethanol as wetting agent, and alcoholic acid volatilizing to safety in production brought a lot of troubles in the dry run after this.And among the present invention with drying, granulate in an operation and finish, potential safety hazard has been reduced in the time and labour saving, and its stable and reliable product quality.
Summary of the invention
(1) technical problem that will solve
Purpose of the present invention aims to provide the preparation method of the medicine of a kind of benefiting vital QI and blood, promoting tissue regeneration by removing blood stasis.
(2) technical scheme
The preparation method of a kind of benefiting vital QI and blood medicine provided by the invention, step is as follows:
(1) takes by weighing following materials of weight proportions: Radix Angelicae Sinensis 20-500, Radix Astragali 20-500, Colla Corii Asini 10-300, Herba Leonuri 20-500, Pericarpium Citri Reticulatae 1-100;
(2) Radix Astragali, Herba Leonuri are added 3-10 times of water gaging and decoct 1-5 time, each 1-3 hour, collecting decoction, filtration, filtrate is concentrated into the clear paste that relative density is 1.10-1.25 (50-90 ℃ time), and is standby;
(3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, doubly measure the ethanol of 40-95% with 3-8 and make solvent, flood percolation after 8-90 hour, collect percolate, and percolate reclaims ethanol and is concentrated into the clear paste that relative density is 1.10-1.25 (50-90 ℃ time), and is standby;
(4) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, Herba Leonuri clear paste, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae clear paste again, mix, add suitable adjuvant and make pharmaceutically acceptable dosage form.
The preferred weight proportioning of raw material of the present invention: Radix Angelicae Sinensis 80-120, Radix Astragali 80-120, Colla Corii Asini 24-36, Herba Leonuri 120-180, Pericarpium Citri Reticulatae 2.4-3.6.
Wherein step (2) be with the Radix Astragali, Herba Leonuri add for the first time 4.8-6 times of water gaging decoct leached decocting liquid in 2 hours after, add 3.2-4.8 times of water gaging for the second time and decocted 1.5 hours, leach decocting liquid, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.10-1.15 (60-70 ℃ time), and is standby.
Wherein step (3) is that Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, doubly measures the ethanol of 60-80% with 4-5 and makes solvent, floods percolation after 40-60 hour, collects percolate, and percolate is evaporated to the clear paste that relative density is 1.10-1.15 (60-70 a ℃), and is standby.
Chinese medicine composition of the present invention can be tablet, capsule, soft capsule, granule, syrup, oral liquid, pill, drop pill or dispersible tablet.
The Chinese medicine composition of the present invention that obtains by said method is a brown granular, gas perfume (or spice), the flavor sweet.
The discrimination method of Chinese medicine composition of the present invention is as follows:
It is a small amount of to get this product, porphyrize, and the dipping 30min that adds diethyl ether, jolting constantly filters, and filtrate volatilizes, and residue adds dehydrated alcohol makes dissolving, as need testing solution.Other gets Radix Angelicae Sinensis control medicinal material 1g, adds ethanol supersound process 20min, filters, and filtrate is medical material solution in contrast.According to thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2000) experiment.Drawing above-mentioned two kinds of solution 5ul, put respectively on same silica gel g thin-layer plate, is developing solvent with normal hexane-ethyl acetate (9-1), launches, and takes out, and dries, and puts under the ultra-violet lamp (365nm) and inspects.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show identical light blue white fluorescent speckle.
Perhaps,
It is a small amount of to get this product, and porphyrize adds methanol reflux 30min, filter, the filtrate evaporate to dryness, residue is dissolved in water, extract 3 times with water saturated n-butyl alcohol jolting, merge n-butyl alcohol liquid, wash with water 3 times, discard water lotion, n-butyl alcohol liquid is put evaporate to dryness, and residue adds methanol makes dissolving, on the neutral alumina post of having handled well (100-200 order), use 40% methanol-eluted fractions, collect eluent, evaporate to dryness, residue add methanol makes dissolving, as need testing solution.Other gets the astragaloside reference substance, adds methanol and makes the solution that contains 1mg among every 1ml, in contrast product solution.According to thin layer chromatography (" appendix VIB of Chinese pharmacopoeia version in 2000) experiment, draw above-mentioned need testing solution 5ul, reference substance solution 3ul, putting respectively on same silica gel g thin-layer plate, is developing solvent with lower floor's solution of chloroform-methanol-water (13-7-2), launches, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and it is clear to be heated to the speckle colour developing at 105 ℃.Put respectively under daylight and the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle and the fluorescence speckle of same color.
The assay photograph N2 method of Chinese medicine composition of the present invention (" appendix Ix.L first method of Chinese pharmacopoeia version in 2000) measure.Wherein nitrogen content must not be less than 12%.
(" an appendix VI of Chinese Pharmacopoeia version in 92000 D " measures the content of Radix Angelicae Sinensis according to high performance liquid chromatography in the Chinese medicine composition of the present invention.
Chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filler; Methanol-1% glacial acetic acid solution (27-73) is a mobile phase; The detection wavelength is 313nm.Number of theoretical plate calculates by the ferulic acid peak should be not less than 1000.
The preparation of reference substance solution: precision takes by weighing the ferulic acid that is dried to constant weight through phosphorus pentoxide, is formulated as the reference substance solution that every 1ml contains ferulic acid 10ug with methanol.
The preparation of need testing solution: get this product porphyrize, mixing is got 1g, accurate claims surely, puts in the 50ml measuring bottle, adds 60% methanol solution 40ml of 1% glacial acetic acid, and supersound process 40min is put coldly, adds mobile phase and is diluted to scale, shakes up, and filters, and gets subsequent filtrate, promptly.
Algoscopy: accurate respectively reference substance solution and each 10ul of need testing solution of drawing, inject hplc determination.
Wherein contain Radix Angelicae Sinensis with ferulic acid (C
10H
10O
4) meter, must not be less than 1.2mg.
The Chinese medicine composition that obtains by preparation method of the present invention has the effect of benefiting vital QI and blood, promoting tissue regeneration by removing blood stasis, is particularly useful for the QI and blood deficiency syndrome of blood stasis puerperal abdonimal pain of holding concurrently.
(3) beneficial effect
The preparation method of benefiting vital QI and blood medicine provided by the invention directly is dissolved in Colla Corii Asini in the medicinal liquid can farthest keep its drug effect, and the present invention with drying, granulate and finish in an operation, potential safety hazard has been reduced in the time and labour saving, and its stable and reliable product quality.
The specific embodiment
Can further be expressly understood the present invention by specific embodiments of the invention given below, but following embodiment not a limitation of the invention.
The preparation method of the Chinese medicine composition tablet of embodiment 1 benefiting vital QI and blood of the present invention
Take by weighing the raw material of following weight:
Radix Angelicae Sinensis 500g, Radix Astragali 500g, Colla Corii Asini 10g, Herba Leonuri 500g, Pericarpium Citri Reticulatae 1g, dextrin 150g;
(1) Radix Astragali, Herba Leonuri being added for the first time the 10kg decocting boils after 1 hour and leaches decocting liquid, adding for the second time the 7kg decocting boils after 1 hour and leaches decocting liquid, adding the 4kg decocting for the third time boils after 1 hour and leaches decocting liquid, adding the 3kg decocting for the 4th time boils after 1 hour and leaches decocting liquid, add the 3kg decocting for the 5th time and boil after 1 hour and leach decocting liquid, merge five times decocting liquid, filter, it is 1.10 clear paste in the time of 90 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 4kg 95% is made solvent, flood percolation after 8 hours, collect percolate, it is 1.10 clear paste in the time of 90 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, adds Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of about 1/2nd amounts, mix, be dried to dried cream powder, adding dextrin 150g, is binding agent with Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of remainder, and mixing is granulated, drying, tabletting, coating, promptly.
The preparation method of the Chinese medicinal composition granules of embodiment 2 benefiting vital QI and blood of the present invention
Take by weighing the raw material of following weight:
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, sucrose 140g, dextrin 105g;
(1) Radix Astragali, Herba Leonuri are added the 3.12kg decocting and boiled 3 hours, leach decocting liquid, it is 1.25 clear paste in the time of 50 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.64kg 40% is made solvent, flood after 90 hours slowly percolation, collect percolate, it is 1.25 clear paste in the time of 50 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the Radix Astragali, Herba Leonuri clear paste, add Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of about 1/2nd amounts, mix, drying adds cane sugar powder, dextrin, is binding agent with Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of remainder, and mixing is made granule, drying, promptly.
The preparation method of the Chinese medicine composition dispersible tablet of embodiment 3 benefiting vital QI and blood of the present invention
Take by weighing the raw material of following weight:
Radix Angelicae Sinensis 20g, Radix Astragali 500g, Colla Corii Asini 300g, Herba Leonuri 20g, Pericarpium Citri Reticulatae 100g, pregelatinized Starch 65g, lactose 50g, carboxymethyl starch sodium 15g, magnesium stearate 2.5g, xylitol 1g;
(1) Radix Astragali, Herba Leonuri are added for the first time the 2.5kg decocting and boil after 2 hours and leach decocting liquid, filtering residue adds the 1.67kg decocting for the second time and boils after 1.5 hours and leach decocting liquid, and it is 1.10 clear paste in the time of 70 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.48kg 80% is made solvent, flood percolation after 40 hours, collect percolate, it is 1.10 clear paste in the time of 70 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, adds Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of about 1/3rd amounts, mix, being concentrated into relative density is the clear paste of 1.25 (70 ℃), is dried to dried cream powder.With dried cream powder, pregelatinized Starch 65g, lactose 50g, carboxymethyl starch sodium 5g mix homogeneously, granulate with Radix Angelicae Sinensis, the moistening of Pericarpium Citri Reticulatae clear paste of remainder, drying, granulate adds carboxymethyl starch sodium 10g, magnesium stearate 2.5g, xylitol 1g mixing, tabletting, promptly.
The preparation method of the Chinese medicinal composition capsules agent of embodiment 4 benefiting vital QI and blood of the present invention
Radix Angelicae Sinensis 500g, Radix Astragali 20g, Colla Corii Asini 20g, Herba Leonuri 500g, Pericarpium Citri Reticulatae 100g, dextrin 70g;
(1) Radix Astragali, Herba Leonuri being added for the first time the 3.12kg decocting boils after 2 hours and leaches decocting liquid, for the second time adding the 2.5kg decocting boiled 1.5 hours, adding the 1.67kg decocting for the third time boils after 1 hour and leaches decocting liquid, adding the 1.56kg decocting for the 4th time boils after 1 hour and leaches decocting liquid, merge four times decocting liquid, filter, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 3kg 60% is made solvent, flood percolation after 60 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, the Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste that add about 2/3rds amounts mix, and being concentrated into relative density is the clear paste of 1.21 (70 ℃), drying is made dried cream powder, add dextrin, with Radix Angelicae Sinensis, the moistening of Pericarpium Citri Reticulatae clear paste of remainder, mixing, granulate, drying, encapsulated, the Chinese medicinal composition capsules agent that promptly gets benefiting vital QI and blood of the present invention.
The preparation method of the Chinese medicine composition pill of embodiment 5 benefiting vital QI and blood of the present invention
Take by weighing the raw material of following weight:
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, lactose 170g, microcrystalline Cellulose 45g, carboxymethyl starch sodium 30g
(1) Radix Astragali, Herba Leonuri are added for the first time 3.12kg water logging bubble and decocted 2 hours after 1 hour, leach decocting liquid, add the 2.6kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merge twice decocting liquid, filter, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.70kg70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, adds Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of about 1/2nd amounts, mix, being concentrated into relative density is the clear paste of 1.20 (80 ℃), and drying is ground into fine powder, add lactose, microcrystalline Cellulose, carboxymethyl starch sodium, mixing is a binding agent system soft material with Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of remainder, the refining ball, pill, drying is 14 hours under 60 ℃ of conditions, and polishing, drying get product.
The preparation method of the Chinese medicine composition syrup of embodiment 6 benefiting vital QI and blood of the present invention
Take by weighing the raw material of following weight:
Radix Angelicae Sinensis 200g, Radix Astragali 200g, Colla Corii Asini 60g, Herba Leonuri 300g, Pericarpium Citri Reticulatae 6g, sucrose 450g, 0.3% sodium benzoate sucrose 3g
(1) Radix Astragali, Herba Leonuri are added for the first time 3kg water logging bubble 1 hour, decoct and leach decocting liquid after 2 hours, add the 2.5kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merge twice decocting liquid, filter, it is 1.12 clear paste in the time of 70 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 1.03kg70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.14 clear paste in the time of 70 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae clear paste, mix, being concentrated into relative density is the clear paste of 1.22 (70 ℃), adds sucrose, heating for dissolving, filter, filtrate adds 0.3% sodium benzoate and stirs evenly, and filters, add an amount of distilled water and stir to 1000ml, promptly get the Chinese medicine composition syrup of benefiting vital QI and blood of the present invention.
The preparation method of the soft capsule of the Chinese medicine composition of embodiment 7 benefiting vital QI and blood of the present invention
Radix Angelicae Sinensis 120g, Radix Astragali 120g, Colla Corii Asini 24g, Herba Leonuri 120g, Pericarpium Citri Reticulatae 2.4g, Cera Flava 1.5g, olive oil 30g, propylene glycol 25g, soybean lecithin 10g
(1) Radix Astragali, Herba Leonuri are added 1.44kg water for the first time, decoct and leach decocting liquid after 2 hours, for the second time add the 1.15kg decocting to boil 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.98kg 70% is made solvent, flood percolation after 60 hours, collect percolate, it is 1.15 clear paste in the time of 70 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae clear paste, mix, being concentrated into relative density is the clear paste of 1.22 (70 ℃), dry, be ground into 100 purpose fine powders, get Cera Flava be dissolved in be preheated among 60 ℃ of disperse medium olive oil 25g standby, get in the olive oil of soybean lecithin, propylene glycol adding remainder, stir, and be fully mixed to 37 ℃ with above-mentioned disperse medium, add above-mentioned medicinal substances extract fine powder, stir, grind homogenizing, make the Chinese medicine composition soft capsule of benefiting vital QI and blood of the present invention.
The preparation method of the drop pill of the Chinese medicine composition of embodiment 8 benefiting vital QI and blood of the present invention
Radix Angelicae Sinensis 80g, Radix Astragali 80g, Colla Corii Asini 36g, Herba Leonuri 180g, Pericarpium Citri Reticulatae 3.6g, Macrogol 4000 200g, polyethylene glycol 6000 20g
(1) Radix Astragali, Herba Leonuri are added the 1.56kg decocting and boil after 2 hours and leach decocting liquid, filter, it is 1.15 clear paste in the time of 70 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 420g 70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 70 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae clear paste, mix, being concentrated into relative density is the thick paste of 1.22 (70 ℃), 60 ℃ of heating and melting of taking polyethylene glycol 4000 and polyethylene glycol 6000 water-bath, the thick paste that adds medicinal substances extract, mix homogeneously splashes in the dimethicone liquid coolant while hot, drips to make drop pill, remove liquid coolant, promptly get the Chinese medicine composition drop pill of benefiting vital QI and blood of the present invention.
The preparation method of the Chinese medicine composition oral solutions of embodiment 9 benefiting vital QI and blood of the present invention
Radix Angelicae Sinensis 120g, Radix Astragali 120g, Colla Corii Asini 36g, Herba Leonuri 120g, Pericarpium Citri Reticulatae 2.4g, simple syrup 100ml, chitosan 10g
(1) Radix Astragali, Herba Leonuri are added for the first time the 1.44kg decocting and boil after 2 hours and leach decocting liquid, add the 1.20kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 610g 70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri extracting solution, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae extracting solution, mix, being concentrated into relative density is the clear paste of 1.10 (70 ℃), adds simple syrup, be concentrated into 1000ml, leave standstill 12h, get supernatant, add antiseptic, packing promptly gets the Chinese medicine composition oral solutions of benefiting vital QI and blood of the present invention.
The preparation method of the Chinese medicinal composition granules of embodiment 10 benefiting vital QI and blood of the present invention
Take by weighing the raw material of following weight:
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, sucrose 140g, dextrin 105g;
(1) Radix Astragali, Herba Leonuri are added for the first time the 3.12kg decocting and boiled 2 hours, leach decocting liquid, for the second time add the 2.5kg decocting to boil 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.86kg 70% is made solvent, flood after 48 hours slowly percolation, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the Radix Astragali, Herba Leonuri clear paste, add Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of about 1/2nd amounts, mix, drying adds cane sugar powder, dextrin, is binding agent with Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of remainder, and mixing is made granule, drying, promptly.
The preparation method of the Chinese medicine composition tablet of embodiment 11 benefiting vital QI and blood of the present invention
Take by weighing the raw material of following weight:
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, dextrin 80g
(1) Radix Astragali, Herba Leonuri are added for the first time the 2.5kg decocting and boil after 2 hours and leach decocting liquid, add the 1.67kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.86kg 70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, adds Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of about 1/2nd amounts, mix, be dried to dried cream powder, add dextrin,, granulate with Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste moistening mixing of remainder, drying, tabletting, coating, promptly.
The preparation method of the Chinese medicine composition dispersible tablet of embodiment 12 benefiting vital QI and blood of the present invention
Take by weighing the raw material of following weight:
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, pregelatinized Starch 52g, lactose 40g, carboxymethyl starch sodium 12g, magnesium stearate 2g, xylitol 1g;
(1) Radix Astragali, Herba Leonuri are added for the first time the 2.6kg decocting and boil after 2 hours and leach decocting liquid, add the 1.67kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.86kg 70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, adds Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste of 1/2nd amounts, mix, being concentrated into relative density is the clear paste of 1.25 (70 ℃), is dried to dried cream powder.With dried cream powder, pregelatinized Starch, lactose, carboxymethyl starch sodium 4g mix homogeneously, granulate with Radix Angelicae Sinensis, the moistening of Pericarpium Citri Reticulatae clear paste of remainder, drying, granulate adds carboxymethyl starch sodium 8g, magnesium stearate 2g, xylitol 1g mixing, tabletting, promptly.
The preparation method of the Chinese medicinal composition capsules agent of embodiment 13 benefiting vital QI and blood of the present invention
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, dextrin 60g;
(1) Radix Astragali, Herba Leonuri are added for the first time the 2.6kg decocting and boil after 2 hours and leach decocting liquid, add the 1.67kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.86kg 70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, the Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste that add about 1/2nd amounts, mix, being concentrated into relative density is the clear paste of 1.21 (70 ℃), and drying is made dried cream powder, add dextrin, with Radix Angelicae Sinensis, the Pericarpium Citri Reticulatae clear paste moistening mixing of remainder, granulate drying, encapsulated, as promptly to get benefiting vital QI and blood of the present invention Chinese medicinal composition capsules agent.
The preparation method of the soft capsule of the Chinese medicine composition of embodiment 14 benefiting vital QI and blood of the present invention
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, Cera Flava 3g, olive oil 60g, propylene glycol 50g, soybean lecithin 20g
(1) Radix Astragali, Herba Leonuri are added for the first time the 2.6kg decocting and boil after 2 hours and leach decocting liquid, add the 1.67kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.86kg 70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae clear paste, mix, being concentrated into relative density is the clear paste of 1.22 (70 ℃), dry, be ground into 100 purpose fine powders, get Cera Flava be dissolved in be preheated among 60 ℃ of disperse medium olive oil 50g standby, get in the olive oil of soybean lecithin, propylene glycol adding remainder, stir, and be fully mixed to 37 ℃ with above-mentioned disperse medium, add above-mentioned medicinal substances extract fine powder, stir, grind homogenizing, make the Chinese medicine composition soft capsule of benefiting vital QI and blood of the present invention.
The preparation method of the drop pill of the Chinese medicine composition of embodiment 15 benefiting vital QI and blood of the present invention
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, Macrogol 4000 400g, polyethylene glycol 6000 40g
(1) Radix Astragali, Herba Leonuri are added for the first time the 3kg decocting and boil after 2 hours and leach decocting liquid, add the 2kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.86kg 70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri clear paste, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae clear paste, mix, being concentrated into relative density is the thick paste of 1.22 (70 ℃), 60 ℃ of heating and melting of taking polyethylene glycol 4000 and polyethylene glycol 6000 water-bath, the thick paste that adds medicinal substances extract, mix homogeneously splashes in the dimethicone liquid coolant while hot, drips to make drop pill, remove liquid coolant, promptly get the Chinese medicine composition drop pill of benefiting vital QI and blood of the present invention.
The preparation method of the Chinese medicine composition oral solutions of embodiment 16 benefiting vital QI and blood of the present invention
Radix Angelicae Sinensis 208.35g, Radix Astragali 208.35g, Colla Corii Asini 62.5g, Herba Leonuri 312.5g, Pericarpium Citri Reticulatae 6.25g, simple syrup 200ml, chitosan 20g
(1) Radix Astragali, Herba Leonuri are added for the first time the 3kg decocting and boil after 2 hours and leach decocting liquid, add the 2kg decocting for the second time and boiled 1.5 hours, leach decocting liquid, merges twice decocting liquid, filtration, it is 1.15 clear paste in the time of 60 ℃ that filtrate is concentrated into relative density, standby;
(2) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (" an appendix I of Chinese pharmacopoeia version in 2005 O), ethanol with 0.86kg 70% is made solvent, flood percolation after 48 hours, collect percolate, it is 1.15 clear paste in the time of 60 ℃ that percolate is evaporated to relative density, standby;
(3) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, the Herba Leonuri extracting solution, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae extracting solution, mix, being concentrated into relative density is the clear paste of 1.10 (70 ℃), adds simple syrup, be concentrated into 1000ml, leave standstill 12h, get supernatant, add antiseptic, packing promptly gets the Chinese medicine composition oral solutions of benefiting vital QI and blood of the present invention.
Claims (6)
1, a kind of preparation method of benefiting vital QI and blood medicine, step is as follows:
(1) takes by weighing following raw material: Radix Angelicae Sinensis, the Radix Astragali, Colla Corii Asini, Herba Leonuri, Pericarpium Citri Reticulatae;
(2) Radix Astragali, Herba Leonuri are added 3-10 times of water gaging and decoct 1-5 time, each 1-3 hour, collecting decoction, filtration, filtrate is concentrated into the clear paste that relative density is 1.10-1.25 (50-90 ℃ time), and is standby;
(3) Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, doubly measure the ethanol of 40-95% with 3-8 and make solvent, flood percolation after 8-90 hour, collect percolate, and percolate reclaims ethanol and is concentrated into the clear paste that relative density is 1.10-1.25 (50-90 ℃ time), and is standby;
(4) Colla Corii Asini is dissolved in the above-mentioned Radix Astragali, Herba Leonuri clear paste, add Radix Angelicae Sinensis, Pericarpium Citri Reticulatae clear paste again, mix, add suitable adjuvant and make pharmaceutically acceptable dosage form.
2, the preparation method of benefiting vital QI and blood medicine as claimed in claim 1 is characterized in that raw material that step (1) takes by weighing by weight ratio: Radix Angelicae Sinensis 20-500, Radix Astragali 20-500, Colla Corii Asini 10-300, Herba Leonuri 20-500, Pericarpium Citri Reticulatae 1-100.
3, the preparation method of benefiting vital QI and blood medicine as claimed in claim 1 or 2 is characterized in that raw material that step (1) takes by weighing by weight ratio: Radix Angelicae Sinensis 80-120, Radix Astragali 80-120, Colla Corii Asini 24-36, Herba Leonuri 120-180, Pericarpium Citri Reticulatae 2.4-3.6.
4, the preparation method of benefiting vital QI and blood medicine as claimed in claim 1, it is characterized in that step (2) be with the Radix Astragali, Herba Leonuri add for the first time 4.8-6 times of water gaging decoct leached decocting liquid in 2 hours after, adding for the second time 3.2-4.8 times of water gaging decocted 1.5 hours, leach decocting liquid, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.10-1.15 (60-70 ℃ time), and is standby.
5, the preparation method of benefiting vital QI and blood medicine as claimed in claim 1, it is characterized in that step (3) is that Radix Angelicae Sinensis, Pericarpium Citri Reticulatae are ground into coarse powder, doubly measure the ethanol of 60-80% with 4-5 and make solvent, flood percolation after 40-60 hour, collect percolate, percolate is evaporated to the clear paste that relative density is 1.10-1.15 (60-70 a ℃), and is standby.
6,, it is characterized in that it is tablet, capsule, soft capsule, granule, syrup, oral liquid, pill, drop pill or dispersible tablet by the medicine of the described preparation method gained of claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA200610011862XA CN1872202A (en) | 2006-05-09 | 2006-05-09 | Method for preparing medication of replenishing qi and the blood |
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| CNA200610011862XA CN1872202A (en) | 2006-05-09 | 2006-05-09 | Method for preparing medication of replenishing qi and the blood |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670796A (en) * | 2012-05-22 | 2012-09-19 | 广西天天乐药业股份有限公司 | Traditional Chinese medicine for treating deficiency of spleen and stomach and preparation method thereof |
| CN102813722A (en) * | 2012-07-28 | 2012-12-12 | 李梅 | Traditional Chinese medicine for lactagogue of puerperas |
| CN103655898A (en) * | 2013-11-21 | 2014-03-26 | 山东东阿阿胶股份有限公司 | Compound colla corii asini syrup capable of treating dysmenorrheal |
-
2006
- 2006-05-09 CN CNA200610011862XA patent/CN1872202A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670796A (en) * | 2012-05-22 | 2012-09-19 | 广西天天乐药业股份有限公司 | Traditional Chinese medicine for treating deficiency of spleen and stomach and preparation method thereof |
| CN102813722A (en) * | 2012-07-28 | 2012-12-12 | 李梅 | Traditional Chinese medicine for lactagogue of puerperas |
| CN103655898A (en) * | 2013-11-21 | 2014-03-26 | 山东东阿阿胶股份有限公司 | Compound colla corii asini syrup capable of treating dysmenorrheal |
| CN103655898B (en) * | 2013-11-21 | 2015-12-02 | 山东东阿阿胶股份有限公司 | The FUFANG EJIAO JIANG of dysmenorrhea can be treated |
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