CN1559527A - Compound stemona cough stopping medicine and its preparation method - Google Patents
Compound stemona cough stopping medicine and its preparation method Download PDFInfo
- Publication number
- CN1559527A CN1559527A CNA2004100141858A CN200410014185A CN1559527A CN 1559527 A CN1559527 A CN 1559527A CN A2004100141858 A CNA2004100141858 A CN A2004100141858A CN 200410014185 A CN200410014185 A CN 200410014185A CN 1559527 A CN1559527 A CN 1559527A
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- CN
- China
- Prior art keywords
- radix
- cough relieving
- stemona root
- compound stemona
- root cough
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010011224 Cough Diseases 0.000 title claims abstract description 54
- 239000003814 drug Substances 0.000 title claims abstract description 53
- 241001671204 Stemona Species 0.000 title claims description 51
- 150000001875 compounds Chemical class 0.000 title claims description 51
- 238000002360 preparation method Methods 0.000 title claims description 25
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 35
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 44
- 239000008187 granular material Substances 0.000 claims description 31
- 239000000047 product Substances 0.000 claims description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 23
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 22
- 239000008361 herbal raw material Substances 0.000 claims description 22
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 22
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 22
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 18
- 239000000706 filtrate Substances 0.000 claims description 16
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 15
- 235000012907 honey Nutrition 0.000 claims description 14
- 239000002994 raw material Substances 0.000 claims description 14
- 210000000582 semen Anatomy 0.000 claims description 14
- 239000000796 flavoring agent Substances 0.000 claims description 11
- 235000019634 flavors Nutrition 0.000 claims description 11
- 239000001530 fumaric acid Substances 0.000 claims description 11
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 11
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 10
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 10
- 239000001630 malic acid Substances 0.000 claims description 10
- 235000011090 malic acid Nutrition 0.000 claims description 10
- 229940109275 cyclamate Drugs 0.000 claims description 9
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims description 9
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 238000001291 vacuum drying Methods 0.000 claims description 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 8
- 239000008101 lactose Substances 0.000 claims description 8
- 239000008107 starch Substances 0.000 claims description 8
- 235000019698 starch Nutrition 0.000 claims description 8
- 229920001353 Dextrin Polymers 0.000 claims description 7
- 239000004375 Dextrin Substances 0.000 claims description 7
- 235000019425 dextrin Nutrition 0.000 claims description 7
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 claims description 4
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims description 4
- 229960003321 baicalin Drugs 0.000 claims description 4
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 3
- 239000003643 water by type Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 11
- 244000144725 Amygdalus communis Species 0.000 abstract 1
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 abstract 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 abstract 1
- 240000000249 Morus alba Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 235000003893 Prunus dulcis var amara Nutrition 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- ZFTFAPZRGNKQPU-UHFFFAOYSA-N dicarbonic acid Chemical compound OC(=O)OC(O)=O ZFTFAPZRGNKQPU-UHFFFAOYSA-N 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 35
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 20
- 238000012360 testing method Methods 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- 229940079593 drug Drugs 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 238000000605 extraction Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 238000004809 thin layer chromatography Methods 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical class [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229960004756 ethanol Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000013558 reference substance Substances 0.000 description 2
- XUCIJNAGGSZNQT-JHSLDZJXSA-N (R)-amygdalin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O[C@@H](C#N)C=2C=CC=CC=2)O1 XUCIJNAGGSZNQT-JHSLDZJXSA-N 0.000 description 1
- ATWHGWYKSFRYBN-UHFFFAOYSA-N Amygdaloside Natural products O1C(=O)C2(C)CCCC(C3CC4)(C)C2C1OCC3(C1)CC4C1(O)COC1OC(CO)C(O)C(O)C1O ATWHGWYKSFRYBN-UHFFFAOYSA-N 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- YEZWWUMWIFKEQM-UHFFFAOYSA-N O.OC.ClC(Cl)Cl.CCOC(C)=O Chemical compound O.OC.ClC(Cl)Cl.CCOC(C)=O YEZWWUMWIFKEQM-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- ONBIUAZBGHXJDM-UHFFFAOYSA-J bismuth;potassium;tetraiodide Chemical compound [K+].[I-].[I-].[I-].[I-].[Bi+3] ONBIUAZBGHXJDM-UHFFFAOYSA-J 0.000 description 1
- QSKWJTXWJJOJFP-UHFFFAOYSA-N chloroform;ethoxyethane Chemical compound ClC(Cl)Cl.CCOCC QSKWJTXWJJOJFP-UHFFFAOYSA-N 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- FYGDTMLNYKFZSV-MRCIVHHJSA-N dextrin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](CO)OC(O[C@@H]2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-MRCIVHHJSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- KXUYYFNHOZRVKP-UHFFFAOYSA-N ethanol;4-hydroxy-3-methoxybenzaldehyde Chemical compound CCO.COC1=CC(C=O)=CC=C1O KXUYYFNHOZRVKP-UHFFFAOYSA-N 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000003760 hair shine Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- LGZXYFMMLRYXLK-UHFFFAOYSA-N mercury(2+);sulfide Chemical compound [S-2].[Hg+2] LGZXYFMMLRYXLK-UHFFFAOYSA-N 0.000 description 1
- DHRLEVQXOMLTIM-UHFFFAOYSA-N phosphoric acid;trioxomolybdenum Chemical compound O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.O=[Mo](=O)=O.OP(O)(O)=O DHRLEVQXOMLTIM-UHFFFAOYSA-N 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000000079 presaturation Methods 0.000 description 1
- XYKIUTSFQGXHOW-UHFFFAOYSA-N propan-2-one;toluene Chemical compound CC(C)=O.CC1=CC=CC=C1 XYKIUTSFQGXHOW-UHFFFAOYSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine in the form of effervescent tablet for treating cough is prepared from 11 Chinese-medicinal materials including bitter almond, mulberry bark, tangerine peel, liquorice root, etc and 3 medicinal additives: citric acid, dicarbonate and polyethanediol 6000.
Description
Technical field
The present invention relates to a kind of is the medicine that raw material is made by Chinese herbal medicine, particularly a kind of compound stemona root cough relieving medicine; The invention still further relates to the preparation method of this medicine.
Background technology
In the prior art, the compound stemona root cough relieving electuary is a kind of Chinese patent medicine of classics.It makes granule by 11 flavor medicines such as the processed with honey Radix Stemonae, Semen Armeniacae Amarum, Radix Platycodonis, Cortex Mori, Radix Ophiopogonis, the Rhizoma Anemarrhenae, Radix Scutellariae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, Rhizoma Arisaematis (processed), Fructus Aurantii (parched), takes after mixing it with hot water during use, and a 10-20 gram, 2-3 time on the one, children's is cut down according to the circumstance.Every bag 10 gram is equivalent to crude drug 6 grams.This compound stemona root cough relieving electuary has the clearing away lung-heat to relieve cough effect, is used for the cough due to lung-heat, the yellow thickness of expectorant, pertussal clinical treatment.Its defective is that said preparation is a granule, and dosage form is comparatively backward, and the granule dose is big, and granule contains a large amount of sucrose; The easy moisture absorption of granule is prone to caking phenomenon in the storage process.
Summary of the invention
Technical problem to be solved by this invention is at the deficiencies in the prior art, provides a kind of effective component content height, dosage form novelty, adjuvant science, taking dose little, mouthfeel and all good compound stemona root cough relieving medicines of outward appearance when taking.
The present invention also provides manufacturing method for above mentioned medicine.
Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of compound stemona root cough relieving medicine, is characterized in, it is the medicament of being made by the raw material of following weight degree, and described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Processed with honey Radix Stemonae 10-15% Semen Armeniacae Amarum 5-8% Radix Platycodonis 5-8%
Cortex Mori 5-8% 2-4% Radix Ophiopogonis Rhizoma Anemarrhenae 2-4%
Radix Scutellariae 10-15% Pericarpium Citri Reticulatae 10-15% Radix Glycyrrhizae 2-4%
Rhizoma Arisaematis (processed) 2-4% Fructus Aurantii (parched) 5-8%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 8-12% sodium bicarbonate 8-12%
Polyethylene glycol 6000 1-4%.
Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of compound stemona root cough relieving medicine is characterized in that it can also add the pharmaceutic adjuvant of following weight percent content,
Starch or dextrin 1-3% Icing Sugar or lactose 1-3%.
Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of compound stemona root cough relieving medicine is characterized in, the percentage by weight of each raw material is,
Herbal raw material:
The processed with honey Radix Stemonae 13% Semen Armeniacae Amarum 6.5% Radix Platycodonis 6.5%
The Cortex Mori Rhizoma Anemarrhenae 3% 6.5% Radix Ophiopogonis 3%
Radix Scutellariae 13% Pericarpium Citri Reticulatae 13% Radix Glycyrrhizae 3%
Rhizoma Arisaematis (processed) 3% Fructus Aurantii (parched) 6.5%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 10%
Polyethylene glycol 6000 3% sodium bicarbonate 10%.
Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of compound stemona root cough relieving medicine is characterized in, the percentage by weight of each raw material is,
Herbal raw material:
The processed with honey Radix Stemonae 13% Semen Armeniacae Amarum 6% Radix Platycodonis 6%
The Cortex Mori Rhizoma Anemarrhenae 3% 6% Radix Ophiopogonis 3%
Radix Scutellariae 13% Pericarpium Citri Reticulatae 13% Radix Glycyrrhizae 3%
Rhizoma Arisaematis (processed) 3% Fructus Aurantii (parched) 6%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 9%
Polyethylene glycol 6000 3% sodium bicarbonate 9%
Starch or dextrin 2% Icing Sugar or lactose 2%.
The invention also discloses a kind of preparation method of compound stemona root cough relieving medicine, be characterized in, its step is as follows:
(1) gets above-mentioned 11 flavor herbal raw materials, add 8-10 times of water gaging and decoct 2-3 time, each 2-3 hour, collecting decoction, filter, filtrate is concentrating under reduced pressure under-0.08--0.10MPa, 70-90 ℃ condition, and the relative density that records until at 50 ℃ the time is the clear paste of 1.30-1.40, then at vacuum drying below 70 ℃, be ground into fine powder, add citric acid or fumaric acid or malic acid, mix homogeneously, granulate drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(2) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, can also add starch or dextrin, Icing Sugar or lactose simultaneously, compacting gets finished product compound stemona root cough relieving effervescent tablet in flakes.
Technical problem to be solved by this invention can also further realize by following technical scheme.The preparation method of above-described a kind of compound stemona root cough relieving medicine is characterized in, every finished product compound stemona root cough relieving effervescent tablet contains Radix Scutellariae with baicalin C
21H
18O
11Meter is not less than 8 milligrams.
Technical problem to be solved by this invention can also further realize by following technical scheme.The preparation method of above-described a kind of compound stemona root cough relieving medicine is characterized in, gets 1 of finished product compound stemona root cough relieving effervescent tablet, and porphyrize drops in 100 ml waters, and stirring and making dissolving, its pH value is 4.0-5.5.
Technical problem to be solved by this invention can also further realize by following technical scheme.Above-described a kind of compound stemona root cough relieving process for preparing medicine is characterized in, gets 6 of finished product compound stemona root cough relieving effervescent tablets, adds 15 ℃ 100 milliliters in water respectively, effervescent tablet disintegrate in 5 minutes.
Medicine of the present invention is light yellow to filemot tablet; It is sweet to distinguish the flavor of, little hardship.
Medicine of the present invention (hereinafter to be referred as this product) is differentiated by the following method:
1. it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, with 30ml 0.5% hydrochloric acid solution supersound extraction 20min, filter, filtrate is regulated PH to 10-11 with strong ammonia solution, with chloroform extraction three times (15ml/ time), combined chloroform liquid, reclaim under reduced pressure to about 1ml as need testing solution.Other gets control medicinal material 2 grams, is ground into fine powder, with 30ml 0.5% hydrochloric acid solution supersound extraction 20min, filter, filtrate is regulated PH to 10-11 with strong ammonia solution, with chloroform extraction three times (15ml/ time), combined chloroform liquid, reclaim under reduced pressure is to about 1ml medical material solution in contrast.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G plate lamellae, with benzene-ethyl acetate-methanol-isopropyl alcohol-strong ammonia solution (12: 6: 3: 3: 1) is developing solvent, put with in 15 minutes the expansion cylinder of ammonia steam presaturation, launch, dry, spray develops the color with bismuth potassium iodide test solution.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the Chinese red principal spot of same color.
2. it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, adds water 30ml and makes dissolving, filters, and filtrate is with water saturated n-butanol extraction three times, and each 25ml merges butanol solution, and reclaim under reduced pressure is to doing, residue with the 5ml dissolve with methanol as need testing solution.It is an amount of that other gets the amygdaloside reference substance, makes about 1mg/ml solution product solution in contrast with dissolve with methanol.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G plate lamellae, (15: 40: 22: 10) 10 ℃ of subnatants of placing 12 hours were developing solvent with chloroform-ethyl acetate-methanol-water, launch, dry, spray is with the phosphomolybdic acid sulfuric acid solution, and 105 ℃ of heating developed the color in 10 minutes.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the principal spot of same color.
3. it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, add saturated sodium carbonate solution 20ml, supersound process 20 minutes filters, filtrate is regulated PH to 1-2 with dilute hydrochloric acid, left standstill 30 minutes, and filtered, filtrate is with ethyl acetate extraction three times, each 15ml, combined ethyl acetate liquid reclaim under reduced pressure is to doing, and residue adds methanol 1ml dissolving, as need testing solution.Other gets Cortex Mori control medicinal material 2g, is ground into fine powder, adds saturated sodium carbonate solution 20ml with method operation preparation control medicinal material solution.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B) test, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same polyamide film, be developing solvent with acetic acid, launch, exhibition is dried apart from 10cm, puts under the ultraviolet 365nm and inspects.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the fluorescence principal spot of same color.
4. it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, add 7% sulphuric acid alcohol-water (1: 3) mixed solution 20ml, reflux 2 hours is put cold, extract 2 times with the chloroform jolting, each 20ml, combined chloroform liquid adds water 30ml washing, chloroform solution is with the 5g anhydrous sodium sulfate dehydration, filter, filtrate decompression is recycled to dried, and residue dissolves as need testing solution with methanol 1ml.Other gets Radix Platycodonis control medicinal material 1g, shines medical material solution in pairs with legal system.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B) test, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G plate lamellae, with chloroform-ether (1: 1) is developing solvent, launches, and dries, spray is with 10% ethanol solution of sulfuric acid, and 105 ℃ of heating developed the color in 10 minutes.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the principal spot of same color.
5. it is an amount of to get this product, is ground into fine powder, takes by weighing 10g, add 80% ethanol 30ml, reflux 30 minutes is put cold, filter, get filtrate 20ml and add hydrochloric acid 2ml, refluxing was concentrated into 5ml in 1 hour, added water 10ml dilution, extract three times with the chloroform jolting, each 15ml, combined chloroform liquid reclaim under reduced pressure is to doing, and residue dissolves as need testing solution with chloroform 1ml.Other gets Rhizoma Anemarrhenae control medicinal material 2g and is equipped with control medicinal material solution with legal system.Test according to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2000 B), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel G plate lamellae, with toluene-acetone (10: 1) is developing solvent, launch, dry, spray is with the mixed solution (1: 10) of 8% vanillin ethanol solution and sulfuric acid solution (7 10), and 100 ℃ of heating developed the color in 10 minutes.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the principal spot of same color.
Take after mixing it with water a 1-2 sheet, 2-3 time on the one with warm water during drug use of the present invention; Children's is cut down according to the circumstance, and its specification is every 4g, is equivalent to crude drug 6g.
The present invention compared with prior art has the following advantages: the dosage form of Juhong Tanke medicine of the present invention is an effervescent tablet, its dosage form advanced person; With the effervescent tablet preparation stabilization of the inventive method preparation, drug safety, dosage is accurate, quality controllable, curative effect reliable, adjuvant science, effective component content height, dose are little; Juhong Tanke effervescent tablet good mouthfeel of the present invention, and solution overall appearance sensation is graceful, and similar soda pop is easy to particularly child patient acceptance of patient; And on the proper mass standard base, increase thin layer discriminating, liquid chromatograph assay item, further effectively control drug quality.
The specific embodiment
Embodiment 1.A kind of compound stemona root cough relieving medicine, it is the medicament of being made by the raw material of following weight content, described pharmaceutical formulation is an effervescent tablet, (unit: gram),
Herbal raw material:
The Radix Stemonae (processed with honey) 100 Semen Armeniacae Amarums 50 Radix Platycodoniss 50
The Cortex Mori Rhizoma Anemarrhenae 25 50 Radix Ophiopogonis 25
Radix Scutellariae 100 Pericarpium Citri Reticulataes 100 Radix Glycyrrhizaes 25
Rhizoma Arisaematis (system) 25 Fructus Aurantii (parched) 50
Pharmaceutic adjuvant:
Citric acid 80 polyethylene glycol 6000s 20 sodium bicarbonate 80.
Embodiment 2.The preparation method of embodiment 1 described a kind of compound stemona root cough relieving medicine, its step is as follows:
(1) gets described 11 flavor herbal raw materials, add 10 times of amounts, the decoction of 8 times of water gagings 2 times respectively, each 2 hours, collecting decoction, filter, filtrate is concentrating under reduced pressure under-0.09MPa, 80 ℃ of conditions, and the relative density that records until at 50 ℃ the time is 1.35 clear paste, then at vacuum drying below 70 ℃, be ground into fine powder, add the citric acid fine powder, mix homogeneously, granulate drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(2) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, be pressed into 100, get finished product compound stemona root cough relieving effervescent tablet.
Embodiment 3.A kind of compound stemona root cough relieving medicine, it is the medicament of being made by the raw material of following weight degree, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The processed with honey Radix Stemonae 13% Semen Armeniacae Amarum 6.5% Radix Platycodonis 6.5%
The Cortex Mori Rhizoma Anemarrhenae 3% 6.5% Radix Ophiopogonis 3%
Radix Scutellariae 13% Pericarpium Citri Reticulatae 13% Radix Glycyrrhizae 3%
Rhizoma Arisaematis (processed) 3% Fructus Aurantii (parched) 6.5%;
Pharmaceutic adjuvant:
Fumaric acid 10% polyethylene glycol 6000 3% sodium bicarbonate 10%.
Embodiment 4.The preparation method of embodiment 3 described a kind of compound stemona root cough relieving medicines, its step is as follows:
(1) gets above-mentioned 11 flavor herbal raw materials, add 8 times of water gagings and decoct the 1st time 3 hours 2 times, the 2nd time 2 hours, collecting decoction filtered, filtrate is concentrating under reduced pressure under-0.08MPa, 85 ℃ of conditions, the relative density that records until at 50 ℃ the time is 1.30 clear paste, at vacuum drying below 70 ℃, is ground into fine powder then, add the fumaric acid fine powder, mix homogeneously is granulated drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(3) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, compacting gets finished product compound stemona root cough relieving effervescent tablet in flakes.
Embodiment 5.A kind of compound stemona root cough relieving medicine, it is the medicament of being made by the raw material of following weight content, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The processed with honey Radix Stemonae 10% Semen Armeniacae Amarum 8% Radix Platycodonis 8%
The Cortex Mori Rhizoma Anemarrhenae 2% 8% Radix Ophiopogonis 2%
Radix Scutellariae 15% Pericarpium Citri Reticulatae 15% Radix Glycyrrhizae 2%
Rhizoma Arisaematis (processed) 2% Fructus Aurantii (parched) 5%;
Pharmaceutic adjuvant:
Malic acid 8% polyethylene glycol 6000 4% sodium bicarbonate 11%.
Its preparation method is:
(1) gets above-mentioned 11 flavor herbal raw materials, add 9 times of water gagings and decoct each 2 hours 3 times, collecting decoction, filter, filtrate is concentrating under reduced pressure under-0.10MPa, 75 ℃ of conditions, and the relative density that records until at 50 ℃ the time is 1.40 clear paste, then at vacuum drying below 70 ℃, be ground into fine powder, add the malic acid fine powder, mix homogeneously, granulate drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(2) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, compacting gets finished product compound stemona root cough relieving effervescent tablet in flakes.
Embodiment 6.A kind of compound stemona root cough relieving medicine, it is the medicament of being made by the raw material of following weight content, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The processed with honey Radix Stemonae 15% Semen Armeniacae Amarum 5% Radix Platycodonis 5%
The Cortex Mori Rhizoma Anemarrhenae 4% 5% Radix Ophiopogonis 4%
Radix Scutellariae 12% Pericarpium Citri Reticulatae 12% Radix Glycyrrhizae 4%
Rhizoma Arisaematis (processed) 4% Fructus Aurantii (parched) 8%;
Pharmaceutic adjuvant:
Citric acid 12% polyethylene glycol 6000 2% sodium bicarbonate 8%.
Its preparation method is,
(1) gets above-mentioned 11 flavor herbal raw materials, add 10 times of water gagings and decoct 2 times, the time 3 hours, collecting decoction, filter, filtrate is concentrating under reduced pressure under-0.09MPa, 90 ℃ of conditions, and the relative density that records until at 50 ℃ the time is 1.35 clear paste, then at vacuum drying below 70 ℃, be ground into fine powder, add the citric acid fine powder, mix homogeneously, granulate drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(2) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, compacting gets finished product compound stemona root cough relieving effervescent tablet in flakes.
Embodiment 7.A kind of compound stemona root cough relieving medicine, it is the medicament of being made by the raw material of following weight content, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The processed with honey Radix Stemonae 14% Semen Armeniacae Amarum 6% Radix Platycodonis 7%
The Cortex Mori Rhizoma Anemarrhenae 3.5% 6% Radix Ophiopogonis 3.5%
Radix Scutellariae 14% Pericarpium Citri Reticulatae 14% Radix Glycyrrhizae 3.5%
Rhizoma Arisaematis (processed) 3.5% Fructus Aurantii (parched) 6%;
Pharmaceutic adjuvant:
Citric acid 9% polyethylene glycol 6000 2% sodium bicarbonate 8%.
Its preparation method is:
(1) gets above-mentioned 11 flavor herbal raw materials, add 10 times of water gagings and decoct each 2.5 hours 2 times, collecting decoction, filter, filtrate is concentrating under reduced pressure under-0.09MPa, 80 ℃ of conditions, and the relative density that records until at 50 ℃ the time is 1.38 clear paste, then at vacuum drying below 70 ℃, be ground into fine powder, add the citric acid fine powder, mix homogeneously, granulate drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(2) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, compacting gets finished product compound stemona root cough relieving effervescent tablet in flakes.
Embodiment 8.Every finished product compound stemona root cough relieving effervescent tablet according to embodiment 5 preparations contains Radix Scutellariae with baicalin C
21H
18O
11Count 8 milligrams.
Embodiment 9.Get according to 1 of the finished product compound stemona root cough relieving effervescent tablet of embodiment 6 preparation, porphyrize drops in 100 ml waters, and stirring and making dissolving, its pH value is 4.5.
Embodiment 10.Get according to 6 of the finished product compound stemona root cough relieving effervescent tablets of embodiment 7 preparation, add 15 ℃ 100 milliliters in water respectively, effervescent tablet disintegrate in 5 minutes.
Embodiment 11.Every finished product compound stemona root cough relieving effervescent tablet according to embodiment 6 preparations contains Radix Scutellariae with baicalin C
21H
18O
11Count 9 milligrams.
Embodiment 12.A kind of compound stemona root cough relieving medicine, it is the medicament of being made by the raw material of following weight content, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The processed with honey Radix Stemonae 13% Semen Armeniacae Amarum 6% Radix Platycodonis 6%
The Cortex Mori Rhizoma Anemarrhenae 3% 6% Radix Ophiopogonis 3%
Radix Scutellariae 13% Pericarpium Citri Reticulatae 13% Radix Glycyrrhizae 3%
Rhizoma Arisaematis (processed) 3% Fructus Aurantii (parched) 6%;
Pharmaceutic adjuvant:
Citric acid 9%
Polyethylene glycol 6000 3% sodium bicarbonate 9%
Starch 2% lactose 2%.
Embodiment 13.The preparation method of embodiment 12 described a kind of compound stemona root cough relieving medicines, its step be,
(1) gets described 11 flavor herbal raw material, add 10 times of water gagings and decoct each 2.5 hours 2 times, collecting decoction, filter, filtrate is concentrating under reduced pressure under-0.09MPa, 80 ℃ of conditions, and the relative density that records until at 50 ℃ the time is 1.38 clear paste, then at vacuum drying below 70 ℃, be ground into fine powder, add the citric acid fine powder, mix homogeneously, granulate drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(2) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, add starch and lactose simultaneously, compacting gets finished product compound stemona root cough relieving effervescent tablet in flakes.
Embodiment 14.A kind of compound stemona root cough relieving medicine, it is the medicament of being made by the raw material of following weight content, described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
The processed with honey Radix Stemonae 12% Semen Armeniacae Amarum 6% Radix Platycodonis 6%
The Cortex Mori Rhizoma Anemarrhenae 4% 6% Radix Ophiopogonis 4%
Radix Scutellariae 12% Pericarpium Citri Reticulatae 11% Radix Glycyrrhizae 4%
Rhizoma Arisaematis (processed) 4% Fructus Aurantii (parched) 6%;
Pharmaceutic adjuvant:
Fumaric acid 8% sodium bicarbonate 8%
Polyethylene glycol 6000 3%
Dextrin 3% Icing Sugar 3%.
Its preparation method is,
(1) gets above-mentioned 11 flavor herbal raw material, add 10 times of water gagings and decoct each 2.5 hours 2 times, collecting decoction, filter, filtrate is concentrating under reduced pressure under-0.09MPa, 80 ℃ of conditions, and the relative density that records until at 50 ℃ the time is 1.38 clear paste, then at vacuum drying below 70 ℃, be ground into fine powder, add the citric acid fine powder, mix homogeneously, granulate drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(2) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, add dextrin and Icing Sugar simultaneously, compacting gets finished product compound stemona root cough relieving effervescent tablet in flakes.
Claims (8)
1, a kind of compound stemona root cough relieving medicine is characterized in that, it is the medicament of being made by the raw material of following weight degree, and described pharmaceutical formulation is an effervescent tablet,
Herbal raw material:
Processed with honey Radix Stemonae 10-15% Semen Armeniacae Amarum 5-8% Radix Platycodonis 5-8%
Cortex Mori 5-8% 2-4% Radix Ophiopogonis Rhizoma Anemarrhenae 2-4%
Radix Scutellariae 10-15% Pericarpium Citri Reticulatae 10-15% Radix Glycyrrhizae 2-4%
Rhizoma Arisaematis (processed) 2-4% Fructus Aurantii (parched) 5-8%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 8-12% sodium bicarbonate 8-12%
Polyethylene glycol 6000 1-4%.
2, a kind of compound stemona root cough relieving medicine according to claim 1 is characterized in that it can also add the pharmaceutic adjuvant of following weight percent content,
Starch or dextrin 1-3% Icing Sugar or lactose 1-3%.
3, a kind of compound stemona root cough relieving medicine according to claim 1 is characterized in that, the percentage by weight of each raw material is,
Herbal raw material:
The processed with honey Radix Stemonae 13% Semen Armeniacae Amarum 6.5% Radix Platycodonis 6.5%
The Cortex Mori Rhizoma Anemarrhenae 3% 6.5% Radix Ophiopogonis 3%
Radix Scutellariae 13% Pericarpium Citri Reticulatae 13% Radix Glycyrrhizae 3%
Rhizoma Arisaematis (processed) 3% Fructus Aurantii (parched) 6.5%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 10%
Polyethylene glycol 6000 3% sodium bicarbonate 10%.
4, a kind of compound stemona root cough relieving medicine according to claim 2 is characterized in that, the percentage by weight of each raw material is,
Herbal raw material:
The processed with honey Radix Stemonae 13% Semen Armeniacae Amarum 6% Radix Platycodonis 6%
The Cortex Mori Rhizoma Anemarrhenae 3% 6% Radix Ophiopogonis 3%
Radix Scutellariae 13% Pericarpium Citri Reticulatae 13% Radix Glycyrrhizae 3%
Rhizoma Arisaematis (processed) 3% Fructus Aurantii (parched) 6%;
Pharmaceutic adjuvant:
Citric acid or fumaric acid or malic acid 9%
Polyethylene glycol 6000 3% sodium bicarbonate 9%
Starch or dextrin 2% Icing Sugar or lactose 2%.
5, the preparation method of any one described a kind of compound stemona root cough relieving medicine of claim 1-4 is characterized in that, its step is as follows:
(1) gets above-mentioned 11 flavor herbal raw materials, add 8-10 times of water gaging and decoct 2-3 time, each 2-3 hour, collecting decoction, filter, filtrate is concentrating under reduced pressure under-0.08--0.10MPa, 70-90 ℃ condition, and the relative density that records until at 50 ℃ the time is the clear paste of 1.30-1.40, then at vacuum drying below 70 ℃, be ground into fine powder, add citric acid or fumaric acid or malic acid, mix homogeneously, granulate drying with dehydrated alcohol; Taking polyethylene glycol 6000 adds sodium bicarbonate with anhydrous alcohol solution in addition, makes granule, drying;
(2) get above-mentioned dried two kinds of granule mix homogeneously, add an amount of cyclamate, essence, can also add starch or dextrin, Icing Sugar or lactose simultaneously, compacting gets finished product compound stemona root cough relieving effervescent tablet in flakes.
6, the preparation method of a kind of compound stemona root cough relieving medicine according to claim 5 is characterized in that, every finished product compound stemona root cough relieving effervescent tablet contains Radix Scutellariae with baicalin C
21H
18O
11Meter is not less than 8 milligrams.
7, the preparation method of a kind of compound stemona root cough relieving medicine according to claim 5 is characterized in that, gets 1 of finished product compound stemona root cough relieving effervescent tablet, and porphyrize drops in 100 ml waters, and stirring and making dissolving, its pH value is 4.0-5.5.
8, the preparation method of a kind of compound stemona root cough relieving medicine according to claim 5 is characterized in that, gets 6 of finished product compound stemona root cough relieving effervescent tablets, adds 15 ℃ 100 milliliters in water respectively, effervescent tablet disintegrate in 5 minutes.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100141858A CN1331523C (en) | 2004-02-25 | 2004-02-25 | Compound stemona cough stopping medicine and its preparation method |
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| CNB2004100141858A CN1331523C (en) | 2004-02-25 | 2004-02-25 | Compound stemona cough stopping medicine and its preparation method |
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| CN1331523C CN1331523C (en) | 2007-08-15 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101024004B (en) * | 2006-02-22 | 2010-08-11 | 北京华医神农医药科技有限公司 | Medicine composition for treating respiratory tract system diseases and its preparation process |
| CN102657805A (en) * | 2012-05-23 | 2012-09-12 | 胡枝清 | Loquat scented tea and preparation technology thereof |
| CN103041141A (en) * | 2012-12-14 | 2013-04-17 | 四川美大康药业股份有限公司 | Preparation method of compound stemona sessilifolia cough-relieving granule |
| CN106226453A (en) * | 2016-08-31 | 2016-12-14 | 天津中新药业研究中心 | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine |
-
2004
- 2004-02-25 CN CNB2004100141858A patent/CN1331523C/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101024004B (en) * | 2006-02-22 | 2010-08-11 | 北京华医神农医药科技有限公司 | Medicine composition for treating respiratory tract system diseases and its preparation process |
| CN102657805A (en) * | 2012-05-23 | 2012-09-12 | 胡枝清 | Loquat scented tea and preparation technology thereof |
| CN102657805B (en) * | 2012-05-23 | 2014-02-05 | 胡枝清 | Loquat scented tea and preparation technology thereof |
| CN103041141A (en) * | 2012-12-14 | 2013-04-17 | 四川美大康药业股份有限公司 | Preparation method of compound stemona sessilifolia cough-relieving granule |
| CN106226453A (en) * | 2016-08-31 | 2016-12-14 | 天津中新药业研究中心 | A kind of method of quality control of removing heat from the lung and dissipating phlegm antitussive medicine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1331523C (en) | 2007-08-15 |
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