CN1775266A - Qianjin cough-relieving preparation and new preparing method - Google Patents
Qianjin cough-relieving preparation and new preparing method Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine composition and its preparation process. In particular, it relates to a Chinese medicine prescription for curing the diseases of cough due to exopathy and accumulation of phlegm and heat in the lung and its preparation process. It can be made into dripping pills and soft capsule preparation.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of affection of exogenous wind-cold cough, the prescription of accumulation of phlegm-heat in the interior and preparation technology thereof of being used for.
Background technology:
The affection of exogenous wind-cold cough, accumulation of phlegm-heat in the interior is clinical common sympton, and the traditional Chinese medical science is often taked dispersing lung-QI and dissipating phlegm, and the means of relieving cough and asthma are treated it, and evident in efficacy, and the Qianjin cough-relieving ball is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, mixture, hard capsule, its pill that makes can be used for curing mainly affection of exogenous wind-cold cough, accumulation of phlegm-heat in the interior.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
25～350 parts of Herba Ephedrae 40～560 portions of Semen Armeniacae Amarums of 50～700 portions of Radix Glycyrrhizaes (stir-fry)
15～210 parts of 15～210 parts of Rhizoma Arisaematiss (system) of 20～280 parts of Radix Scutellariaes of Rhizoma Pinelliae Preparatum (wine steaming)
15～210 parts of 15～210 parts of Radix Platycodoniss of 15～210 portions of Herba Menthaes of Fructus Perillae (stir-fry)
15～210 parts of 15～210 parts of Pericarpium Citri Reticulataes of 15～210 parts of Cortex Mori of Bulbus Fritillariae Thunbergii
10～140 parts of Radix Asteriss
Preferably:
50 parts of Herba Ephedrae 80 portions of Semen Armeniacae Amarums of 100 portions of Radix Glycyrrhizaes (stir-fry)
30 parts of 30 parts of Rhizoma Arisaematiss (system) of 40 parts of Radix Scutellariaes of Rhizoma Pinelliae Preparatum (wine steaming)
30 parts of 30 parts of Radix Platycodoniss of 30 portions of Herba Menthaes of Fructus Perillae (stir-fry)
30 parts of 30 parts of Pericarpium Citri Reticulataes of 30 parts of Cortex Mori of Bulbus Fritillariae Thunbergii
20 parts of Radix Asteriss
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, mixture.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) gets Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 3～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials beats powder and is used as medicine;
(2) all the other medical materials are handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, phlegm-dispelling functions
Get 60 of Kunming mouses, laboratory adapts to 3d, is divided into 4 groups at random by sex, body weight, and 15 every group, be respectively the normal saline matched group, Radix Polygalae decoct matched group and technology is the extractum group 1., and technology is the extractum group 2..Irritate the corresponding medicinal liquid of stomach respectively, every day 1 time, 7d continuously.0.5h after the last administration, each organizes the phenol red normal saline 0.1ml/10g of the equal lumbar injection 5% of mice, animal is put to death in dislocation behind the 30min, peel off the trachea surrounding tissue, cut one section trachea down to the trachea crotch from thyroid cartilage, put into the test tube that fills the 2ml normal saline, add the sodium hydroxide of 0.1ml5% again.With 722 type spectrophotometers, survey the OD value at wavelength 540nm place, with the phenol red standard curve of doing, calculate phenol red content (μ g/ml) according to standard curve, see Table 1.The result shows that each extractum group all has the phenol red effect of the trachea excretion of enhancing.
The phlegm-dispelling functions of table 1 pair mice (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | The phenol red excretion amount of trachea (μ g/ml) |
| Matched group Radix Polygalae water decoction group technology is 2. extractum group of extractum group technology 1. | 15 15 15 15 | - 1.0 0.09 0.23 | 0.072±0.05 0.257±0.15 ***0.228±0.10 ***0.201±0.05 *** |
Compare with the blank group
*P＜0.05,
*P＜0.01,
* *P＜0.001 (down together)
2, to the antitussive effect of mice
Get 40 of kunming mices, be divided into 4 groups at random, 10 every group, male and female half and half are respectively the normal saline matched group, and positive drug pentoxyverine matched group and technology is the extractum group 1., and technology is the extractum group 2..The corresponding medicinal liquid 0.5ml/20g of the disposable filling stomach of difference, 1h after administration carries out the antitussive experiment.During experiment respectively with each group mice by only putting into bell glass, the cover infantile tic has a filter paper, and (2cm * 2cm) is with 0.3ml ammonia (25%～28%NH
4OH), being added to stimulates mice on the filter paper, continues to stimulate 30s, takes out the cough number of times in mice observation and record mouse cough incubation period and the 2min.The result shows, each extractum group mouse cough significant prolongation incubation period (P＜0.05), and the cough number of times significantly reduces (P＜0.05), sees Table 2.Show that the cough that this medicine causes chemical stimulation has certain antitussive effect.The results are shown in Table 2.
The influence of table 2 pair ammonia induced mice cough (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Cough latent period (t/min) | Cough number of times (2min) |
| Matched group pentoxyverine technology is 2. extractum group of extractum group technology 1. | 10 10 10 10 | - 1.00 0.09 0.23 | 0.27±0.22 1.12±0.71 *1.01±0.54 *0.201±0.05 * | 13.20±4.44 5.40±5.50 *5.60±5.30 *7.40±5.74 * |
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment affection of exogenous wind-cold coughs, the medicine of accumulation of phlegm-heat in the interior, and change preparation technology, can obviously strengthen its dispersing lung-QI and dissipating phlegm, clinical efficacies such as relieving cough and asthma, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Herba Ephedrae 250g Radix Glycyrrhizae 200g Semen Armeniacae Amarum (stir-fry) 125g
Rhizoma Pinelliae Preparatum 100g Radix Scutellariae (wine steaming) 75g Rhizoma Arisaematis (system) 75g
Fructus Perillae (stir-fry) 75g Herba Menthae 75g Radix Platycodonis 75g
Bulbus Fritillariae Thunbergii 75g Cortex Mori 75g Pericarpium Citri Reticulatae 75g
Radix Asteris 50g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) gets Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 6 with β-CD ratio, and ultrasonic 40min gets clathrate;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 12h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Herba Ephedrae 570g Radix Glycyrrhizae 456g Semen Armeniacae Amarum (stir-fry) 285g
Rhizoma Pinelliae Preparatum 228g Radix Scutellariae (wine steaming) 171g Rhizoma Arisaematis (system) 171g
Fructus Perillae (stir-fry) 171g Herba Menthae 171g Radix Platycodonis 171g
Bulbus Fritillariae Thunbergii 171g Cortex Mori 171g Pericarpium Citri Reticulatae 171g
Radix Asteris 114g
PEG400 270g
Make 1000
Preparation method:
(1) gets Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 6 with β-CD ratio, and ultrasonic 40min gets clathrate;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 12h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Herba Ephedrae 700g Radix Glycyrrhizae 560g Semen Armeniacae Amarum (stir-fry) 350g
Rhizoma Pinelliae Preparatum 280g Radix Scutellariae (wine steaming) 210g Rhizoma Arisaematis (system) 210g
Fructus Perillae (stir-fry) 210g Herba Menthae 210g Radix Platycodonis 210g
Bulbus Fritillariae Thunbergii 210g Cortex Mori 210g Pericarpium Citri Reticulatae 210g
Radix Asteris 140g
Make 1000g
Preparation method:
(1) getting Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials beats powder and is used as medicine;
(2) all the other medical materials are handled the same;
(3) above active component is merged, add aspartame 5.0g, dextrin 310.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4
The preparation method of chewable tablet of the present invention:
Prescription:
Herba Ephedrae 277g Radix Glycyrrhizae 222g Semen Armeniacae Amarum (stir-fry) 138.5g
Rhizoma Pinelliae Preparatum 111g Radix Scutellariae (wine steaming) 83g Rhizoma Arisaematis (system) 83g
Fructus Perillae (stir-fry) 83g Herba Menthae 83g Radix Platycodonis 83g
Bulbus Fritillariae Thunbergii 83g Cortex Mori 83g Pericarpium Citri Reticulatae 83g
Radix Asteris 55.5g
Make 1000
Preparation method:
(1) getting Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials beats powder and is used as medicine;
(2) all the other medical materials are handled the same;
(3) above active component is merged, add aspartame 3.0g, mannitol 230.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
25～350 parts of Herba Ephedrae 40～560 portions of Semen Armeniacae Amarums of 50～700 portions of Radix Glycyrrhizaes (stir-fry)
15～210 parts of 15～210 parts of Rhizoma Arisaematiss (system) of 20～280 parts of Radix Scutellariaes of Rhizoma Pinelliae Preparatum (wine steaming)
15～210 parts of 15～210 parts of Radix Platycodoniss of 15～210 portions of Herba Menthaes of Fructus Perillae (stir-fry)
15～210 parts of 15～210 parts of Pericarpium Citri Reticulataes of 15～210 parts of Cortex Mori of Bulbus Fritillariae Thunbergii
10～140 parts of Radix Asteriss.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
50 parts of Herba Ephedrae 80 portions of Semen Armeniacae Amarums of 100 portions of Radix Glycyrrhizaes (stir-fry)
30 parts of 30 parts of Rhizoma Arisaematiss (system) of 40 parts of Radix Scutellariaes of Rhizoma Pinelliae Preparatum (wine steaming)
30 parts of 30 parts of Radix Platycodoniss of 30 portions of Herba Menthaes of Fructus Perillae (stir-fry)
30 parts of 30 parts of Pericarpium Citri Reticulataes of 30 parts of Cortex Mori of Bulbus Fritillariae Thunbergii
20 parts of Radix Asteriss.
3, claim 1 or any one Chinese medicine preparation of 2 are various suitable dosage forms such as drop pill, soft capsule, granule, chewable tablet, mixture, hard capsule.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) gets Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 3～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials beats powder and is used as medicine;
(2) all the other medical materials are handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) gets Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 3～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Herba Menthae, Pericarpium Citri Reticulatae two flavor medical materials beats powder and is used as medicine;
(2) all the other medical materials are handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101159798A CN1775266A (en) | 2005-11-18 | 2005-11-18 | Qianjin cough-relieving preparation and new preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101159798A CN1775266A (en) | 2005-11-18 | 2005-11-18 | Qianjin cough-relieving preparation and new preparing method |
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Cited By (4)
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| CN105213751A (en) * | 2015-11-16 | 2016-01-06 | 周建卿 | A kind of Chinese medicine composition for the treatment of cough |
| CN105998481A (en) * | 2016-06-20 | 2016-10-12 | 昆明理工大学 | Chinese herbal medicine compound preparation for relieving cough and eliminating phlegm and preparation method thereof |
| CN108969616A (en) * | 2018-09-12 | 2018-12-11 | 赖庭荣 | A kind of cough emplastrum and preparation method thereof |
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2005
- 2005-11-18 CN CNA2005101159798A patent/CN1775266A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2011000149A1 (en) * | 2009-06-30 | 2011-01-06 | 河北以岭医药研究院有限公司 | Pharmaceutical composition containing ephedrae for treating bronchitis and preparation method therefor |
| CN105213751A (en) * | 2015-11-16 | 2016-01-06 | 周建卿 | A kind of Chinese medicine composition for the treatment of cough |
| CN105998481A (en) * | 2016-06-20 | 2016-10-12 | 昆明理工大学 | Chinese herbal medicine compound preparation for relieving cough and eliminating phlegm and preparation method thereof |
| CN108969616A (en) * | 2018-09-12 | 2018-12-11 | 赖庭荣 | A kind of cough emplastrum and preparation method thereof |
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