CN1824099A - Diffusing-freeing lung rectifying medicinal preparation and its new preparation method - Google Patents
Diffusing-freeing lung rectifying medicinal preparation and its new preparation method Download PDFInfo
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating cold cough, fever, headache, sore of limbs, etc, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of cold cough that is used for, fever with chills, the nasal obstruction watery nasal discharge, it is lossless to have a headache, the prescription of limb aching pain and preparation technology thereof.
Background technology:
Cold cough, fever with chills, the nasal obstruction watery nasal discharge, it is lossless have a headache, and limb aching pain is to see symptom clinical more, and the traditional Chinese medical science is often taked the cold expelling that induces sweat, and the means of lung qi dispersing antitussive are treated it, and evident in efficacy.Tongxuan lifei pills is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, chewable tablet, its pill that makes can be used for curing mainly cold cough, fever with chills, nasal obstruction watery nasal discharge, it is lossless to have a headache, limb aching pain.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
36～338 parts of 48～451 portions of Semen Armeniacae Amarums of 48～451 parts of Radix Platycodoniss of 72～677 parts of Radix Peucedanis of Folium Perillae
36～338 parts of 48～451 parts of Rhizoma Pinelliae (processed) of 36～338 parts of Pericarpium Citri Reticulataes of 48～451 portions of Radix Glycyrrhizaes of Herba Ephedrae
48～451 parts of 48～451 parts of Radix Scutellariaes of 48～451 parts of Fructus Aurantii (parched) of Poria
Preferably:
72 parts of 96 portions of Semen Armeniacae Amarums of 96 parts of Radix Platycodoniss of 144 parts of Radix Peucedanis of Folium Perillae
72 parts of 96 parts of Rhizoma Pinelliae (processed) of 72 parts of Pericarpium Citri Reticulataes of 96 portions of Radix Glycyrrhizaes of Herba Ephedrae
96 parts of 96 parts of Radix Scutellariaes of 96 parts of Fructus Aurantii (parched) of Poria
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls etc.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, chewable tablet, syrup, fluid extract and extractum.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) gets Folium Perillae, Pericarpium Citri Reticulatae two flavor medical materials, adopt supercritical extraction: in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0～4.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating I), and 34.8 ℃ (separating II) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get extraction back residue and prescription residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction, filter, filtrate is condensed into certain volume, adds 60～95% ethanol of 3～15 times of amounts, stirs, leave standstill, deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Folium Perillae, the Pericarpium Citri Reticulatae medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2: the content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the chewable tablet preparation is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, pharmacological research
1.1 antitussive effect (strong aqua ammonia nebulization)
Get 40 of the Kunming kind white mice of 18～20g, male and female half and half are divided into 4 groups at random.Irritate stomach and give medicine and normal saline, every day 1 time, 3d continuously.Before irritating stomach on the 3rd day, water 12h is can't help in the mice fasting; 1h after the last administration covers mice with the 500ml beaker, feed the strong aqua ammonia 15s with the ultrasound atomizer atomizing, and mice is taken out stop 10s again in beaker after immediately.Cough latent period of observed and recorded mice (spraying finished to the time that begins to occur coughing) and 3min cough number of times the results are shown in Table 1.
The antitussive effect of table 1 pair mice (n=10, x ± s)
| Group | Dosage (g/kg) | Incubation period (s) | Cough number of times in the 3min |
| Normal saline group JIZHI TANGJIANG group | Equal-volume 10 | 64.41±19.72 88.32±13.48 ** | 28.7±4.78 15.2±2.13 ** |
| Technology is 2. extractum group of extractum group technology 1. | 0.29 0.86 | 110.74±21.38 **△ 93.87±18.45 ** | 10.1±2.36 **△ 15.2±3.66 ** |
Annotate: compare with the normal saline group
*Compare with the JIZHI TANGJIANG group P＜0.01
△P＜0.05
By table 1 as seen, extractum group and JIZHI TANGJIANG group all can obviously reduce the mouse cough number of times, prolong cough latent period, with normal saline group comparing difference highly significant; Technology 2. extractum group effect is suitable with the effect of JIZHI TANGJIANG group, and technology 1. extractum group effect is better than the JIZHI TANGJIANG group.
1.2 phlegm-dispelling functions
Get 40 of 20～24g mices, male and female half and half are divided into 4 groups at random.Irritate stomach respectively and give medicine and normal saline.Every day 1 time, 3d continuously.Before irritating stomach on the 3rd day, water 12h is can't help in the mice fasting; Behind the gastric infusion 30min, every mouse peritoneal is injected 0.5% phenol red solution 0.5ml.Injection back 30min takes off neck and puts to death, and faces upward the position and is fixed on the operation plate, cuts off neck center skin, isolates trachea, and it is standby to wear a silk thread under trachea.No. 7 syringe needles that polish with the tip insert about 0.3cm in the trachea from thyroid cartilage, fix with the silk thread ligation.Draw 5%NaHCO with the 1ml syringe
3Solution 0.5ml, lavation respiratory tract 3 times is put into a test tube with irrigating solution, draws 5%NaHCO again
3Solution 0.5ml, as above lavation 3 times again, altogether washing liquid 1.5ml, 3 washing liquids are merged. with the centrifugal 15min of 3000r/min, get supernatant, survey the OD value in 560nm place colorimetric with 721 type spectrophotometers.According to phenol red standard curve, optical density value is converted into phenol red content, the results are shown in Table 2.
The phlegm-dispelling functions of table 2 pair mice (n=10, x ± s)
| Group | Dosage (g/kg) | Trachea phenol red output (μ g/ml) |
| Normal saline group JIZHI TANGJIANG group technology is 2. extractum group of extractum group technology 1. | Equal-volume 10 0.29 0.86 | 0.78±0.12 3.41±0.27 ** 3.46±0.32 **△ 1.19±0.16 **△△ |
Annotate: compare with the normal saline group
*Compare with the JIZHI TANGJIANG group P＜0.01
△P＜0.05,
△ △P＜0.01
By table 2 as seen, extractum group and JIZHI TANGJIANG group all can obviously increase mouse breathing road phenol red output, with normal saline group comparing difference highly significant; Technology 1. extractum group effect is suitable with the effect of JIZHI TANGJIANG group.
1.3 antiinflammatory action (Mus ear swelling method)
Get 40 of 18～20g male mices, be divided into 4 groups at random.Irritate stomach and give medicine and normal saline.Every day 1 time, 3d continuously.30min after the last administration, 0.1ml caused by dimethylbenzene xylene inflammation is evenly smeared on the two sides before and after each mice left side auricle.Take off neck behind the 1h and put to death mice, cut two ears along the auricle baseline, lay auricle at same position respectively with the card punch of ф 8mm and weigh, calculating is the swelling degree with the difference of two auricle weight, obtains the inhibitory rate of intumesce of administration group by following formula, the results are shown in Table 3.
Swelling degree=left ear-auris dextra
The effect of table 3 pair mice auricle swelling (n=10, x ± s)
| Group | Dosage (g/kg) | Auricle swelling degree (mg) | Relative inhibition (%) |
| Normal saline group JIZHI TANGJIANG group technology is 2. extractum group of extractum group technology 1. | Equal-volume 10 0.29 0.86 | 12.11±1.24 6.13±0.04 ** 5.15±0.37 **△ 7.28±0.46 **△△ | 0 47.98 57.47 39.88 |
Annotate: compare with the normal saline group
*Compare with the JIZHI TANGJIANG group P＜0.01
△P＜0.05,
△ △P＜0.01
By table 3 as seen, extractum group and JIZHI TANGJIANG group all can suppress the Mus ear swelling due to the dimethylbenzene, compare the difference highly significant with the normal saline group; Technology 1. extractum group effect is better than the JIZHI TANGJIANG group.
2, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment cold coughs, fever with chills, the nasal obstruction watery nasal discharge, it is lossless to have a headache, the medicine of limb aching pain, and change preparation technology can obviously strengthen its cold expelling that induces sweat, clinical efficacies such as lung qi dispersing antitussive, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Folium Perillae 144g Radix Peucedani 96g Radix Platycodonis 96g Semen Armeniacae Amarum 72g
Herba Ephedrae 96g Radix Glycyrrhizae 72g Pericarpium Citri Reticulatae 96g Rhizoma Pinelliae (processed) 72g
Poria 96g Fructus Aurantii (parched) 96g Radix Scutellariae 96g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) gets Folium Perillae, Pericarpium Citri Reticulatae two flavor medical materials, adopt supercritical extraction: in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating I), and 34.8 ℃ (separating II) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 7 with the water ratio, and oil is 1: 4 with β-CD ratio, and ultrasonic 30min gets clathrate;
(2) get extraction back residue and prescription residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 8 times of amounts, stirred, and left standstill, and deepfreeze 24h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Folium Perillae 677g Radix Peucedani 451g Radix Platycodonis 451g Semen Armeniacae Amarum 338g
Herba Ephedrae 451g Radix Glycyrrhizae 338g Pericarpium Citri Reticulatae 451g Rhizoma Pinelliae (processed) 338g
Poria 451g Fructus Aurantii (parched) 451g Radix Scutellariae 451g
PEG4000 530g
Make 1000
Preparation method:
(1) gets Folium Perillae, Pericarpium Citri Reticulatae two flavor medical materials, adopt supercritical extraction: in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating I), and 34.8 ℃ (separating II) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 7 with the water ratio, and oil is 1: 4 with β-CD ratio, and ultrasonic 30min gets clathrate;
(2) get extraction back residue and prescription residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 8 times of amounts, stirred, and left standstill, and deepfreeze 24h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of chewable tablet of the present invention:
Prescription:
Folium Perillae 238g Radix Peucedani 158g Radix Platycodonis 158g Semen Armeniacae Amarum 119g
Herba Ephedrae 158g Radix Glycyrrhizae 119g Pericarpium Citri Reticulatae 158g Rhizoma Pinelliae (processed) 119g
Poria 158g Fructus Aurantii (parched) 158g Radix Scutellariae 158g
Make 1000
Preparation method:
(1) get Folium Perillae, the Pericarpium Citri Reticulatae medical material is beaten powder and is used as medicine;
(2) get prescription residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 8 times of amounts, stirred, and left standstill, and deepfreeze 24h filters, and filtrate is condensed into thick paste;
(3) above active component is merged, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
36～338 parts of 48～451 portions of Semen Armeniacae Amarums of 48～451 parts of Radix Platycodoniss of 72～677 parts of Radix Peucedanis of Folium Perillae
36～338 parts of 48～451 parts of Rhizoma Pinelliae (processed) of 36～338 parts of Pericarpium Citri Reticulataes of 48～451 portions of Radix Glycyrrhizaes of Herba Ephedrae
48～451 parts of 48～451 parts of Radix Scutellariaes of 48～451 parts of Fructus Aurantii (parched) of Poria.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
72 parts of 96 portions of Semen Armeniacae Amarums of 96 parts of Radix Platycodoniss of 144 parts of Radix Peucedanis of Folium Perillae
72 parts of 96 parts of Rhizoma Pinelliae (processed) of 72 parts of Pericarpium Citri Reticulataes of 96 portions of Radix Glycyrrhizaes of Herba Ephedrae
96 parts of 96 parts of Radix Scutellariaes of 96 parts of Fructus Aurantii (parched) of Poria.
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, soft capsule, chewable tablet, syrup, fluid extract and extractum.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) gets Folium Perillae, Pericarpium Citri Reticulatae two flavor medical materials, adopt supercritical extraction: in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0～4.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating I), and 34.8 ℃ (separating II) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get extraction back residue and prescription residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction, filter, filtrate is condensed into certain volume, adds 60～95% ethanol of 3～15 times of amounts, stirs, leave standstill, deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Folium Perillae, the Pericarpium Citri Reticulatae medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) gets Folium Perillae, Pericarpium Citri Reticulatae two flavor medical materials, adopt supercritical extraction: in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0～4.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating I), and 34.8 ℃ (separating II) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～6 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get extraction back residue and prescription residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction, filter, filtrate is condensed into certain volume, adds 60～95% ethanol of 3～15 times of amounts, stirs, leave standstill, deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Folium Perillae, the Pericarpium Citri Reticulatae medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152379B (en) * | 2006-09-26 | 2010-04-14 | 来柏龄 | Traditional Chinese medicine for treating cough and technique of preparing the same |
| CN101755975A (en) * | 2010-01-25 | 2010-06-30 | 中山市新运来医药科技开发有限公司大涌分公司 | Chinese herbal medicine sugar and tea drink preparation for preventing and treating cold |
| CN104013755A (en) * | 2014-05-28 | 2014-09-03 | 王庚禹 | Extract product for preparation of lung ventilating and regulating preparation |
-
2005
- 2005-12-15 CN CN 200510134421 patent/CN1824099A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152379B (en) * | 2006-09-26 | 2010-04-14 | 来柏龄 | Traditional Chinese medicine for treating cough and technique of preparing the same |
| CN101755975A (en) * | 2010-01-25 | 2010-06-30 | 中山市新运来医药科技开发有限公司大涌分公司 | Chinese herbal medicine sugar and tea drink preparation for preventing and treating cold |
| CN104013755A (en) * | 2014-05-28 | 2014-09-03 | 王庚禹 | Extract product for preparation of lung ventilating and regulating preparation |
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