CN1943610A - Chinese medicine preparation for traumatic injury and blood stasis and swelling pain - Google Patents
Chinese medicine preparation for traumatic injury and blood stasis and swelling pain Download PDFInfo
- Publication number
- CN1943610A CN1943610A CN 200610113881 CN200610113881A CN1943610A CN 1943610 A CN1943610 A CN 1943610A CN 200610113881 CN200610113881 CN 200610113881 CN 200610113881 A CN200610113881 A CN 200610113881A CN 1943610 A CN1943610 A CN 1943610A
- Authority
- CN
- China
- Prior art keywords
- preparation
- parts
- active component
- volatile oil
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a compound of traditional Chinese medicine and its means of manufacturing , especially relates to a prescription for disease of trauma such as injuries from falls, blood stasis, sprain, blooding from injuries etc. The formulation of said compound could be made in accordance with clinical requirements.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of traumatic injury that is used for, swelling and pain due to blood stasis, traumatic hemorrhage is dampened, and sprains the prescription of diseases such as bone injury and preparation technology thereof.
Background technology:
Traumatic injury, swelling and pain due to blood stasis, traumatic hemorrhage is dampened, and sprains, and bone injury is clinically to see that symptom, the traditional Chinese medical science often take the means of removing stasis to stop bleeding, reducing swelling and alleviating pain that it is treated more, and evident in efficacy.It is that it represents medicine that the compound recipe Radix Notoginseng looses.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, mixture, its pill that makes can be used for curing mainly and is used for traumatic injury, swelling and pain due to blood stasis, traumatic hemorrhage, dampen, sprain diseases such as bone injury.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
35～140 parts of 35～140 parts of Eupolyphaga Seu Steleophagas of 150～600 parts of Radixs Angelicae Dahuricae of Radix Notoginseng
35～140 parts on 35～140 parts of Flos Carthamis of 35～140 parts of Radix Angelicae Sinensis of Rhizoma Chuanxiong
35～140 parts of 35～140 parts of Myrrha (processed) of Olibanum (system).
Preferably:
70 parts of 70 parts of Eupolyphaga Seu Steleophagas of 300 parts of Radixs Angelicae Dahuricae of Radix Notoginseng
70 parts on 70 parts of Flos Carthamis of 70 parts of Radix Angelicae Sinensis of Rhizoma Chuanxiong
70 parts of 70 parts of Myrrha (processed) of Olibanum (system).
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, fluid extract and extractum, soft extract, powder.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) preparation of volatile oil: get Olibanum, put and break into pieces after refrigerator and cooled is frozen 2h, put and add 1.5 times in water in the 5000ml round-bottomed flask, behind the dipping 0.5h, by " an appendix XD of Chinese pharmacopoeia determination of volatile oil method is extracted, Olibanum volatile oil; Get Myrrha, water flowing steam distillation method is extracted volatile oil after the coarse pulverization, distillate with extracted with diethyl ether after low temperature fling to ether, volatile oil.Pulp water separates standby.
(2) preparation of water soluble ingredient: get above-mentioned water extract, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate becomes thick paste (1.40,60 ℃ of heat of relative density are surveyed) through 0.08MPa, 80 ℃ of concentrating under reduced pressure, gets dry extract in 60 ℃ of drying under reduced pressure.
(3) get the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(4) Flos Carthami, Eupolyphaga Seu Steleophaga medical material are decocted with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(5) get the residue medical material, soaked 30～90 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
Method b:(technology 2.)
(1) get Flos Carthami, Olibanum, Myrrha and be ground into impalpable powder, standby;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as granule of the present invention and chewable tablet.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, analgesic test
1.1 hot plate causes the pain method and gets (20 ± 2) g female mice, places the super constant temperature of 501 types [(55 ± 0.5) ℃] water-bath.Measure the threshold of pain on the hot plate, the screening threshold of pain is 40 of 10～30s mices, divides 4 groups at random, gastric infusion.Behind the medicine 30,60,120min surveys the threshold of pain respectively, the results are shown in Table 1.The result show technology 1. the extractum group significant analgesia role is arranged.
Table 1 pair mice hot plate cause the pain influence (x ± s, n=10)
| Group | Dosage (g/kg) | Threshold of pain time expand t/s behind the medicine | ||
| 30min | 60min | 120min | ||
| Normal saline Hyndarin technology is 2. extractum group of extractum group technology 1. | - 0.03 0.10 0.28 | 3.65±3.21 8.91±7.33 6.24±3.58 4.15±4.03 | 3.80±3.45 18.76±13.10 * 11.81±6.48 * 3.97±1.42 | 4.73±4.27 15.86±15.13 9.79±3.47 * 3.52±0.79 |
Annotate: compare with normal saline,
*P＜0.05
1.2 writhing method
Get 40 of (20 ± 2) g mices, male and female half and half are divided into 4 groups, gastric infusion at random.45min behind the medicine, every Mus is the ip0.6% glacial acetic acid solution respectively.Observe take place in the mice 15min turn round the body number of times.The results are shown in Table 2.The extractum group is turned round the body frequency to ip glacial acetic acid induced mice and is obviously reduced as seen from Table 2.
The influence of writhing response due to the table 2 pair mice glacial acetic acid (x ± s, n=10)
| Group | Dosage (g/kg) | Turn round the body frequency |
| Normal saline Hyndarin group technology is 2. extractum group of extractum group technology 1. | - 0.03 0.10 0.28 | 30.4±4.7 16.1±3.5 * 17.4±5.7 * 18.7±3.8 * |
Annotate: compare with normal saline,
*P＜0.05
2, to the influence of hemorheology of rat
Get 40 of SD rats, the male and female dual-purpose is divided into 4 groups at random, behind the successive administration 15d, and the anesthesia of 25% urethane, carotid artery blood-letting 5ml measures the blood flow variate in the heparin test tube, the results are shown in Table 3.Compare with matched group, can reduce plasma viscosity, can improve hemorheological property.
The influence of table 3 pair hemorheology of rat (x ± s, n=10)
| Group | Dosage (g/kg) | Whole blood viscosity (maps) | Plasma viscosity (mpas) | |
| 15.3(l/s) | 115(l/s) | 230(l/s) | ||
| Matched group technology is 1. extractum winding bone notoginseng-containing tablet of extractum group technology 1. | - 0.05 0.14 4.0 | 12.15±4.19 10.27±2.18 10.32±1.71 10.15±1.67 | 6.39±1.11 5.62±0.67 5.54±0.66 6.01±0.58 | 2.88±0.48 2.12±0.31 *** 2.20±0.21 *** 2.38±0.24 ** |
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment traumatic injury, swelling and pain due to blood stasis, traumatic hemorrhage is dampened, sprain, the medicine of diseases such as bone injury, and change preparation technology, can obviously strengthen clinical efficacies such as its removing stasis to stop bleeding, reducing swelling and alleviating pain, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Radix Notoginseng 300g Radix Angelicae Dahuricae 70g Eupolyphaga Seu Steleophaga 70g
Rhizoma Chuanxiong 70g Radix Angelicae Sinensis 70g Flos Carthami 70g
Olibanum (system) 70g Myrrha (processed) 70g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) preparation of volatile oil: get Olibanum, put and break into pieces after refrigerator and cooled is frozen 2h, put and add 1.5 times in water in the 5000ml round-bottomed flask, behind the dipping 0.5h, by " an appendix XD of Chinese pharmacopoeia determination of volatile oil method is extracted, Olibanum volatile oil; Get Myrrha, water flowing steam distillation method is extracted volatile oil after the coarse pulverization, distillate with extracted with diethyl ether after low temperature fling to ether, volatile oil.Pulp water separates standby.
(2) preparation of water soluble ingredient: get above-mentioned water extract, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate becomes thick paste (1.40,60 ℃ of heat of relative density are surveyed) through 0.08MPa, 80 ℃ of concentrating under reduced pressure, gets dry extract in 60 ℃ of drying under reduced pressure.
(3) get the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 30min gets clathrate;
(4) Flos Carthami, Eupolyphaga Seu Steleophaga medical material are decocted with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(5) get the residue medical material, soaked 30 minutes earlier with 80% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(6) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Radix Notoginseng 300g Radix Angelicae Dahuricae 70g Eupolyphaga Seu Steleophaga 70g
Rhizoma Chuanxiong 70g Radix Angelicae Sinensis 70g Flos Carthami 70g
Olibanum (system) 70g Myrrha (processed) 70g
PEG400 370g
Make 1000
Preparation method:
(1) preparation of volatile oil: get Olibanum, put and break into pieces after refrigerator and cooled is frozen 2h, put and add 1.5 times in water in the 5000ml round-bottomed flask, behind the dipping 0.5h, by " an appendix XD of Chinese pharmacopoeia determination of volatile oil method is extracted, Olibanum volatile oil; Get Myrrha, water flowing steam distillation method is extracted volatile oil after the coarse pulverization, distillate with extracted with diethyl ether after low temperature fling to ether, volatile oil.Pulp water separates standby.
(2) preparation of water soluble ingredient: get above-mentioned water extract, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate becomes thick paste (1.40,60 ℃ of heat of relative density are surveyed) through 0.08MPa, 80 ℃ of concentrating under reduced pressure, gets dry extract in 60 ℃ of drying under reduced pressure.
(3) get the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 30min gets clathrate;
(4) Flos Carthami, Eupolyphaga Seu Steleophaga medical material are decocted with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(5) get the residue medical material, soaked 30 minutes earlier with 80% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(6) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Radix Notoginseng 300g Radix Angelicae Dahuricae 70g Eupolyphaga Seu Steleophaga 70g
Rhizoma Chuanxiong 70g Radix Angelicae Sinensis 70g Flos Carthami 70g
Olibanum (system) 70g Myrrha (processed) 70g
Make 1000g
Preparation method:
(1) get Olibanum, Myrrha, Flos Carthami and be ground into impalpable powder, standby;
(2) get the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, adopt steam distillation (or supercritical extraction):, extract according to an appendix X of pharmacopeia in 2005 D essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 30min gets clathrate;
(3) the Eupolyphaga Seu Steleophaga medical material is decocted with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(4) get the residue medical material, soaked 30 minutes earlier with 80% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(5) above active component is merged, add aspartame 5.0g, dextrin 260.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Radix Notoginseng 300g Radix Angelicae Dahuricae 70g Eupolyphaga Seu Steleophaga 70g
Rhizoma Chuanxiong 70g Radix Angelicae Sinensis 70g Flos Carthami 70g
Olibanum (system) 70g Myrrha (processed) 70g
Make 1000
Preparation method:
(1) get Olibanum, Myrrha, Flos Carthami and be ground into impalpable powder, standby;
(2) get the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 30min gets clathrate;
(3) the Eupolyphaga Seu Steleophaga medical material is decocted with water 3 times, each 1 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(4) get the residue medical material, soaked 30 minutes earlier with 80% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(5) above active component is merged, add aspartame 3.0g, mannitol 310.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of sick and wounded Chinese medicine preparation such as traumatic injury, swelling and pain due to blood stasis for the treatment of, it is characterized in that: according to weight proportion, it is by 150～600 parts of Radix Notoginseng, 35～140 parts of the Radixs Angelicae Dahuricae, 35～140 parts of Eupolyphaga Seu Steleophagas, 35～140 parts of Rhizoma Chuanxiongs, 35～140 parts of Radix Angelicae Sinensis, 35～140 parts on Flos Carthami, 35～140 parts of Olibanums (system), 35～140 parts of Myrrha (processed).
2, the Chinese medicine preparation of claim 1 is characterized in that, described basic side's proportioning is: 300 parts of Radix Notoginseng, 70 parts of the Radixs Angelicae Dahuricae, 70 parts of Eupolyphaga Seu Steleophagas, 70 parts of Rhizoma Chuanxiongs, 70 parts of Radix Angelicae Sinensis, 70 parts on Flos Carthami, 70 parts of Olibanums (system), 70 parts of Myrrha (processed).
3, any one Chinese medicine preparation of claim 2 is drop pill, capsule, granule, tablet, mixture, fluid extract and extractum, soft extract, powder.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) preparation of volatile oil: get Olibanum, put and break into pieces after refrigerator and cooled is frozen 2h, put and add 1.5 times in water in the 5000ml round-bottomed flask, behind the dipping 0.5h, by " an appendix XD of Chinese pharmacopoeia determination of volatile oil method is extracted, Olibanum volatile oil; Get Myrrha, water flowing steam distillation method is extracted volatile oil after the coarse pulverization, distillate with extracted with diethyl ether after low temperature fling to ether, volatile oil.Pulp water separates standby.
(2) preparation of water soluble ingredient: get above-mentioned water extract, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate becomes thick paste (1.40,60 ℃ of heat of relative density are surveyed) through 0.08MPa, 80 ℃ of concentrating under reduced pressure, gets dry extract in 60 ℃ of drying under reduced pressure.
(3) get the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(4) Flos Carthami, Eupolyphaga Seu Steleophaga medical material are decocted with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(5) get the residue medical material, soaked 30～90 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
Method b:(technology 2.)
(1) get Flos Carthami, Olibanum, Myrrha and be ground into impalpable powder, standby;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as granule of the present invention and chewable tablet.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg ~ 500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) preparation of volatile oil: get Olibanum, put and break into pieces after refrigerator and cooled is frozen 2h, put and add 1.5 times in water in the 5000ml round-bottomed flask, behind the dipping 0.5h, by " an appendix XD of Chinese pharmacopoeia determination of volatile oil method is extracted, Olibanum volatile oil; Get Myrrha, water flowing steam distillation method is extracted volatile oil after the coarse pulverization, distillate with extracted with diethyl ether after low temperature fling to ether, volatile oil.Pulp water separates standby.
(2) preparation of water soluble ingredient: get above-mentioned water extract, add 2 times of amount 95% ethanol precipitate with ethanol, leave standstill 24h, decompress filter, filtrate becomes thick paste (1.40,60 ℃ of heat of relative density are surveyed) through 0.08MPa, 80 ℃ of concentrating under reduced pressure, gets dry extract in 60 ℃ of drying under reduced pressure.
(3) get the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(4) Flos Carthami, Eupolyphaga Seu Steleophaga medical material are decocted with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(5) get the residue medical material, soaked 30～90 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
Method b:(technology 2.)
(1) get Flos Carthami, Olibanum, Myrrha and be ground into impalpable powder, standby;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as granule of the present invention and chewable tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610113881 CN1943610A (en) | 2006-10-20 | 2006-10-20 | Chinese medicine preparation for traumatic injury and blood stasis and swelling pain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610113881 CN1943610A (en) | 2006-10-20 | 2006-10-20 | Chinese medicine preparation for traumatic injury and blood stasis and swelling pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1943610A true CN1943610A (en) | 2007-04-11 |
Family
ID=38043404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610113881 Pending CN1943610A (en) | 2006-10-20 | 2006-10-20 | Chinese medicine preparation for traumatic injury and blood stasis and swelling pain |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1943610A (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185667B (en) * | 2007-12-11 | 2010-12-08 | 童小桃 | Orally-administered medicine wine for treating lumbar sprain |
| CN102908394A (en) * | 2012-11-20 | 2013-02-06 | 韩永芳 | Chinese medicament for activating promoting blood circulation to remove blood stasis and relieving pains |
| CN102940751A (en) * | 2012-11-06 | 2013-02-27 | 王小宇 | Dieda (Chinese Name) blood-activating dropping pill and preparation method thereof |
| CN103271969A (en) * | 2013-06-21 | 2013-09-04 | 陕西立众制药有限公司 | Traditional Chinese medicine composition for treating traumatic injury and quality control method thereof |
| CN103285060A (en) * | 2013-06-28 | 2013-09-11 | 陕西立众制药有限公司 | Traditional Chinese medicine composition for promoting blood circulation to stop pain, and eliminating blood stasis and promoting tissue regeneration, and preparation method thereof |
| CN103463162A (en) * | 2013-09-16 | 2013-12-25 | 江苏正大清江制药有限公司 | Preparation method of flos carthami dropping pill |
| CN103720807A (en) * | 2014-01-15 | 2014-04-16 | 张孝明 | Medicinal liquor for removing blood stasis and treating bone fracture |
| CN103784550A (en) * | 2014-02-26 | 2014-05-14 | 焦文鹏 | Traditional Chinese medicinal composition for relieving swelling and pain and preparation thereof |
| CN104189687A (en) * | 2014-08-09 | 2014-12-10 | 陈振西 | Medicinal liquor for bone fracture and preparation method thereof |
| CN104435559A (en) * | 2013-09-12 | 2015-03-25 | 郭勇峰 | Externally used traditional Chinese medicine for traumatic edema pain |
| CN104606316A (en) * | 2014-12-29 | 2015-05-13 | 王琪 | Traditional Chinese medicinal mixture for treating traumatic injuries |
| CN104815146A (en) * | 2015-04-15 | 2015-08-05 | 纪洪伟 | Fracture setting capsule |
| CN104940501A (en) * | 2015-07-27 | 2015-09-30 | 刘杰 | Drug used for treating injuries from falls and uncontrollable bleeding |
-
2006
- 2006-10-20 CN CN 200610113881 patent/CN1943610A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185667B (en) * | 2007-12-11 | 2010-12-08 | 童小桃 | Orally-administered medicine wine for treating lumbar sprain |
| CN102940751A (en) * | 2012-11-06 | 2013-02-27 | 王小宇 | Dieda (Chinese Name) blood-activating dropping pill and preparation method thereof |
| CN102940751B (en) * | 2012-11-06 | 2015-12-16 | 王小宇 | A kind of promoting blood circulation and traumatic injury drop pill and preparation method thereof |
| CN102908394A (en) * | 2012-11-20 | 2013-02-06 | 韩永芳 | Chinese medicament for activating promoting blood circulation to remove blood stasis and relieving pains |
| CN103271969A (en) * | 2013-06-21 | 2013-09-04 | 陕西立众制药有限公司 | Traditional Chinese medicine composition for treating traumatic injury and quality control method thereof |
| CN103285060A (en) * | 2013-06-28 | 2013-09-11 | 陕西立众制药有限公司 | Traditional Chinese medicine composition for promoting blood circulation to stop pain, and eliminating blood stasis and promoting tissue regeneration, and preparation method thereof |
| CN104435559A (en) * | 2013-09-12 | 2015-03-25 | 郭勇峰 | Externally used traditional Chinese medicine for traumatic edema pain |
| CN103463162A (en) * | 2013-09-16 | 2013-12-25 | 江苏正大清江制药有限公司 | Preparation method of flos carthami dropping pill |
| CN103720807A (en) * | 2014-01-15 | 2014-04-16 | 张孝明 | Medicinal liquor for removing blood stasis and treating bone fracture |
| CN103784550A (en) * | 2014-02-26 | 2014-05-14 | 焦文鹏 | Traditional Chinese medicinal composition for relieving swelling and pain and preparation thereof |
| CN104189687A (en) * | 2014-08-09 | 2014-12-10 | 陈振西 | Medicinal liquor for bone fracture and preparation method thereof |
| CN104606316A (en) * | 2014-12-29 | 2015-05-13 | 王琪 | Traditional Chinese medicinal mixture for treating traumatic injuries |
| CN104815146A (en) * | 2015-04-15 | 2015-08-05 | 纪洪伟 | Fracture setting capsule |
| CN104815146B (en) * | 2015-04-15 | 2018-04-10 | 朱冯兰 | Bone-knitting capsule |
| CN104940501A (en) * | 2015-07-27 | 2015-09-30 | 刘杰 | Drug used for treating injuries from falls and uncontrollable bleeding |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1943610A (en) | Chinese medicine preparation for traumatic injury and blood stasis and swelling pain | |
| CN1748767A (en) | Lupus preparation and new preparing method | |
| CN1748774A (en) | Brain tonifying preparation and new preparing method | |
| CN1823910A (en) | Joint pain preparation and its new preparation method | |
| CN1775246A (en) | Preparation for treating breast sore and new preparing method | |
| CN1748748A (en) | Little leaf deervetch herb preparation for pregnant woman and new preparing method | |
| CN1824160A (en) | Yin nourishing lung clearing medicinal preparation and its new preparation method | |
| CN1850264A (en) | Safflower preparation for treating wound and new preparing method | |
| CN1879799A (en) | Menstruation-regulating preparation with asiabell and cassia bark and method for preparing same | |
| CN1824109A (en) | Liaoyuanqili medicinal preparation and its new preparation method | |
| CN1823978A (en) | Hemorrhoid blood stopping agent and its preparation method | |
| CN1748741A (en) | Little leaf deervetch herb acne removing preparation and new preparing method | |
| CN1857574A (en) | Deafness treating Tongqiao Preparation and its preparing process | |
| CN1827159A (en) | Menstruation-regulating preparation and novel method for preparing the same | |
| CN1775238A (en) | Anti-inflammtory anti-dysentery preparation and new preparing method | |
| CN1943694A (en) | A Chinese traditional medicinal composition for treating renal deficiency, edema, lumbago and gonalgia, etc. | |
| CN1775243A (en) | Zhanhua hairy Antler formulation and new preparing method | |
| CN1824128A (en) | Semen locking medicinal preparation and its new preparation method | |
| CN1775258A (en) | Womb-warming pregnancy-aiding preparation and new preparing method | |
| CN1824241A (en) | Medicinal preparation and its new preparation method | |
| CN1833689A (en) | Asthma stop preparation and novel prepn. | |
| CN1824099A (en) | Diffusing-freeing lung rectifying medicinal preparation and its new preparation method | |
| CN1824079A (en) | Anti appendicitis preparation and its new preparation method | |
| CN1775248A (en) | Dried tangerine peel sputum-resolving preparation and new preparing method | |
| CN101032572A (en) | Sanguisorba huaijiao agent and the novel preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C57 | Notification of unclear or unknown address | ||
| DD01 | Delivery of document by public notice |
Addressee: Yang Ziyi Document name: Notice of publication of application for patent for invention |
|
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20070411 |