CN1850264A - Safflower preparation for treating wound and new preparing method - Google Patents
Safflower preparation for treating wound and new preparing method Download PDFInfo
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- CN1850264A CN1850264A CN 200610057279 CN200610057279A CN1850264A CN 1850264 A CN1850264 A CN 1850264A CN 200610057279 CN200610057279 CN 200610057279 CN 200610057279 A CN200610057279 A CN 200610057279A CN 1850264 A CN1850264 A CN 1850264A
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Abstract
The present invention relates to a Chinese medicine composition and its preparation process, in particular, it relates to a prescription for curing traumatic injury and its preparation process. It can be made into dripping pills and soft capsule preparation.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of prescription and preparation technology thereof who is used for osteopatia sprain, long-pending swelling due to stasis.
Background technology:
Osteopatia sprain, long-pending swelling due to stasis are clinically to see that symptom, the traditional Chinese medical science often take the means of promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain that it is treated more, and evident in efficacy.The Flos Carthami pill for traumatic injuries is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, tablet, its pill that makes can be used for curing mainly osteopatia sprain, long-pending swelling due to stasis.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
31～81.5 parts of 54.5～143 parts of Fructus Aurantii Immaturuss of 31～81.5 parts of Radix Et Rhizoma Rhei of Flos Carthami
31～81.5 parts on 54.5～143 parts of Pericarpium Citri Reticulatae Virides of 54.5～143 portions of Rhizoma Cyperis of Radix Angelicae Sinensis (vinegar system)
31～81.5 parts of 47～122 parts of Pericarpium Citri Reticulataes of 15.5～41 portions of Radix Curcumaes of Rhizoma Drynariae (processed with wine)
31～81.5 parts of 31～81.5 parts of Pollen Typhaes of 31～81.5 parts of Rhizoma Curcumae of Pseudobulbus Bletillae (Rhizoma Bletillae) (system)
31～81.5 parts of 31～81.5 parts of Radixs Linderae of 31～81.5 parts of Radix Saposhnikoviaes of Cortex Moutan
31～81.5 parts of 31～81.5 parts of Radix Dipsaci 31g～81.5 of rhizoma sparganic (system) portion Radix Aconitis (system)
15.5～41 parts of 23～61 parts of Fructus Amomis of 23～61 parts of Radix Clematidis of Oletum Trogopterori
15.5～41 parts in 31～81.5 portions of Radix Notoginsengs of 15.5～41 parts of Radix Paeoniae Rubra of the Radix Aucklandiae.
Preferably:
36 parts of 63 parts of Fructus Aurantii Immaturuss of 36 parts of Radix Et Rhizoma Rhei of Flos Carthami
36 parts on 63 parts of Pericarpium Citri Reticulatae Virides of 63 portions of Rhizoma Cyperis of Radix Angelicae Sinensis (vinegar system)
36 parts of 54 parts of Pericarpium Citri Reticulataes of 18 portions of Radix Curcumaes of Rhizoma Drynariae (processed with wine)
36 parts of 36 parts of Pollen Typhaes of 36 parts of Rhizoma Curcumae of Pseudobulbus Bletillae (Rhizoma Bletillae) (system)
36 parts of 36 parts of Radixs Linderae of 36 parts of Radix Saposhnikoviaes of Cortex Moutan
36 parts of rhizoma sparganic (system) 36 portions of Radix Aconitis of 36 parts of Radix Dipsacis (system)
18 parts of 27 parts of Fructus Amomis of 27 parts of Radix Clematidis of Oletum Trogopterori
18 parts in 36 portions of Radix Notoginsengs of 18 parts of Radix Paeoniae Rubra of the Radix Aucklandiae.
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, fluid extract and extractum, soft extract, powder.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) get Flos Carthami, Radix Et Rhizoma Rhei, Rhizoma Drynariae, Pollen Typhae (decocting a drug wrapped), the Radix Linderae, Radix Notoginseng medical material, soaked 30～90 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get Pseudobulbus Bletillae (Rhizoma Bletillae), rhizoma sparganic, Radix Dipsaci, Radix Aconiti, Oletum Trogopterori (decocting a drug wrapped), Radix Clematidis, Radix Paeoniae Rubra medical material, decoct with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) taking technique 1. water carry medical material and directly beat powder and be used as medicine;
(2) all the other medical materials are handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets tablet.
Filler described in granule, the preparation tablets is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, analgesic test
1.1 hot plate causes the pain method and gets (20 ± 2) g female mice, places the super constant temperature of 501 types [(55 ± 0.5) ℃] water-bath.Measure the threshold of pain on the hot plate, the screening threshold of pain is 40 of 10～30s mices, divides 4 groups at random, gastric infusion.Behind the medicine 30,60,120min surveys the threshold of pain respectively, the results are shown in Table 1.The result show technology 1. the extractum group significant analgesia role is arranged.
Table 1 pair mice hot plate cause the pain influence (x ± s, n=10)
| Group | Dosage (g/kg) | Threshold of pain time expand t/s behind the medicine | ||
| 30min | 60min | 120min | ||
| Normal saline Hyndarin technology is 2. extractum group of extractum group technology 1. | - 0.03 0.10 0.28 | 3.65±3.21 8.91±7.33 6.24±3.58 4.15±4.03 | 3.80±3.45 18.76±13.10 * 11.81±6.48 * 3.97±1.42 | 4.73±4.27 15.86±15.13 9.79±3.47 * 3.52±0.79 |
Annotate: compare with normal saline,
*P＜0.05
1.2 writhing method
Get 40 of (20 ± 2) g mices, male and female half and half are divided into 4 groups, gastric infusion at random.45min behind the medicine, every Mus is the ip0.6% glacial acetic acid solution respectively.Observe take place in the mice 15min turn round the body number of times.The results are shown in Table 2.The extractum group is turned round the body frequency to ip glacial acetic acid induced mice and is obviously reduced as seen from Table 2.
The influence of writhing response due to the table 2 pair mice glacial acetic acid (x ± s, n=10)
| Group | Dosage (g/kg) | Turn round the body frequency |
| Normal saline Hyndarin group technology is 2. extractum group of extractum group technology 1. | - 0.03 0.10 0.28 | 30.4±4.7 16.1±3.5 * 17.4±5.7 * 18.7±3.8 * |
Annotate: compare with normal saline,
*P＜0.05
2, to the influence of hemorheology of rat
Get 40 of SD rats, the male and female dual-purpose is divided into 4 groups at random, behind the successive administration 15d, and the anesthesia of 25% urethane, carotid artery blood-letting 5ml measures the blood flow variate in the heparin test tube, the results are shown in Table 3.Compare with matched group, can reduce plasma viscosity, can improve hemorheological property.
The influence of table 3 pair hemorheology of rat (x ± s, n=10)
| Group | Dosage (g/kg) | Whole blood viscosity (maps) | Plasma viscosity (mpas) | |
| 15.3(l/s) | 115(l/s) | 230(l/s) | ||
| Matched group technology is 1. extractum winding bone notoginseng-containing tablet of extractum group technology 1. | - 0.05 0.14 4.0 | 12.15±4.19 10.27±2.18 10.32±1.71 10.15±1.67 | 6.39±1.11 5.62±0.67 5.54±0.66 6.01±0.58 | 2.88±0.48 2.12±0.31 ***2.200.21 ***2.38±0.24 ** |
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good osteopatia sprain, the medicine of long-pending swelling due to stasis, and change preparation technology, can obviously strengthen clinical efficacies such as its promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Flos Carthami 31g Radix Et Rhizoma Rhei 54.5g Fructus Aurantii Immaturus 31g
Radix Angelicae Sinensis 54.5g Rhizoma Cyperi (vinegar system) 54.5g Pericarpium Citri Reticulatae Viride 31g
Rhizoma Drynariae (processed with wine) 15.5g Radix Curcumae 47g Pericarpium Citri Reticulatae 31g
Pseudobulbus Bletillae (Rhizoma Bletillae) 31g Rhizoma Curcumae (system) 31g Pollen Typhae 31g
Cortex Moutan 31g Radix Saposhnikoviae 31g Radix Linderae 31g
Rhizoma sparganic (system) 31g Radix Dipsaci 31g Radix Aconiti (system) 31g
Oletum Trogopterori 23g Radix Clematidis 23g Fructus Amomi 15.5g
Radix Aucklandiae 15.5g Radix Paeoniae Rubra 31g Radix Notoginseng 15.5g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) get Flos Carthami, Radix Et Rhizoma Rhei, Rhizoma Drynariae, Pollen Typhae (decocting a drug wrapped), the Radix Linderae, Radix Notoginseng medical material, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get Pseudobulbus Bletillae (Rhizoma Bletillae), rhizoma sparganic, Radix Dipsaci, Radix Aconiti, Oletum Trogopterori (decocting a drug wrapped), Radix Clematidis, Radix Paeoniae Rubra medical material, decoct with water 2 times, each 1.5 hours, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(4) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Flos Carthami 156g Radix Et Rhizoma Rhei 273g Fructus Aurantii Immaturus 156g
Radix Angelicae Sinensis 273g Rhizoma Cyperi (vinegar system) 273g Pericarpium Citri Reticulatae Viride 156g
Rhizoma Drynariae (processed with wine) 78g Radix Curcumae 234g Pericarpium Citri Reticulatae 156g
Pseudobulbus Bletillae (Rhizoma Bletillae) 156g Rhizoma Curcumae (system) 156g Pollen Typhae 156g
Cortex Moutan 156g Radix Saposhnikoviae 156g Radix Linderae 156g
Rhizoma sparganic (system) 156g Radix Dipsaci 156g Radix Aconiti (system) 156g
Oletum Trogopterori 117g Radix Clematidis 117g Fructus Amomi 78g
Radix Aucklandiae 78g Radix Paeoniae Rubra 156g Radix Notoginseng 78g
PEG400 590g
Make 1000
Preparation method:
(1) get Flos Carthami, Radix Et Rhizoma Rhei, Rhizoma Drynariae, Pollen Typhae (decocting a drug wrapped), the Radix Linderae, Radix Notoginseng medical material, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get Pseudobulbus Bletillae (Rhizoma Bletillae), rhizoma sparganic, Radix Dipsaci, Radix Aconiti, Oletum Trogopterori (decocting a drug wrapped), Radix Clematidis, Radix Paeoniae Rubra medical material, decoct with water 2 times, each 1.5 hours, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(4) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Flos Carthami 81.5g Radix Et Rhizoma Rhei 143g Fructus Aurantii Immaturus 81.5g
Radix Angelicae Sinensis 143g Rhizoma Cyperi (vinegar system) 143g Pericarpium Citri Reticulatae Viride 81.5g
Rhizoma Drynariae (processed with wine) 41g Radix Curcumae 122g Pericarpium Citri Reticulatae 81.5g
Pseudobulbus Bletillae (Rhizoma Bletillae) 81.5g Rhizoma Curcumae (system) 81.5g Pollen Typhae 81.5g
Cortex Moutan 81.5g Radix Saposhnikoviae 81.5g Radix Linderae 81.5g
Rhizoma sparganic (system) 81.5g Radix Dipsaci 81.5g Radix Aconiti (system) 81.5g
Oletum Trogopterori 61g Radix Clematidis 61g Fructus Amomi 41g
Radix Aucklandiae 41g Radix Paeoniae Rubra 12g Radix Notoginseng 41g
Make 1000g
Preparation method:
(1) get Flos Carthami, Radix Et Rhizoma Rhei, Rhizoma Drynariae, Pollen Typhae (decocting a drug wrapped), the Radix Linderae, Radix Notoginseng medical material, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) getting Pseudobulbus Bletillae (Rhizoma Bletillae), rhizoma sparganic, Radix Dipsaci, Radix Aconiti, Oletum Trogopterori (decocting a drug wrapped), Radix Clematidis, Radix Paeoniae Rubra medical material directly beats powder and is used as medicine;
(3) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(4) above active component is merged, add aspartame 5.0g, dextrin 300.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of sheet of the present invention:
Prescription:
Flos Carthami 36g Radix Et Rhizoma Rhei 63g Fructus Aurantii Immaturus 36g
Radix Angelicae Sinensis 63g Rhizoma Cyperi (vinegar system) 63g Pericarpium Citri Reticulatae Viride 36g
Rhizoma Drynariae (processed with wine) 18g Radix Curcumae 54g Pericarpium Citri Reticulatae 36g
Pseudobulbus Bletillae (Rhizoma Bletillae) 36g Rhizoma Curcumae (system) 36g Pollen Typhae 36g
Cortex Moutan 36g Radix Saposhnikoviae 36g Radix Linderae 36g
Rhizoma sparganic (system) 36g Radix Dipsaci 36g Radix Aconiti (system) 36g
Oletum Trogopterori 27g Radix Clematidis 27g Fructus Amomi 18g
Radix Aucklandiae 18g Radix Paeoniae Rubra 36g Radix Notoginseng 18g
Make 1000
Preparation method:
(1) get Flos Carthami, Radix Et Rhizoma Rhei, Rhizoma Drynariae, Pollen Typhae (decocting a drug wrapped), the Radix Linderae, Radix Notoginseng medical material, soaked 40 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) getting Pseudobulbus Bletillae (Rhizoma Bletillae), rhizoma sparganic, Radix Dipsaci, Radix Aconiti, Oletum Trogopterori (decocting a drug wrapped), Radix Clematidis, Radix Paeoniae Rubra medical material directly beats powder and is used as medicine;
(3) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(4) above active component is merged, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
31～81.5 parts of 54.5～143 parts of Fructus Aurantii Immaturuss of 31～81.5 parts of Radix Et Rhizoma Rhei of Flos Carthami
31～81.5 parts on 54.5～143 parts of Pericarpium Citri Reticulatae Virides of 54.5～143 portions of Rhizoma Cyperis of Radix Angelicae Sinensis (vinegar system)
31～81.5 parts of 47～122 parts of Pericarpium Citri Reticulataes of 15.5～41 portions of Radix Curcumaes of Rhizoma Drynariae (processed with wine)
31～81.5 parts of 31～81.5 parts of Pollen Typhaes of 31～81.5 parts of Rhizoma Curcumae of Pseudobulbus Bletillae (Rhizoma Bletillae) (system)
31～81.5 parts of 31～81.5 parts of Radixs Linderae of 31～81.5 parts of Radix Saposhnikoviaes of Cortex Moutan
31～81.5 parts of 31～81.5 parts of Radix Dipsaci 31g～81.5 of rhizoma sparganic (system) portion Radix Aconitis (system)
15.5～41 parts of 23～61 parts of Fructus Amomis of 23～61 parts of Radix Clematidis of Oletum Trogopterori
15.5～41 parts in 31～81.5 portions of Radix Notoginsengs of 15.5～41 parts of Radix Paeoniae Rubra of the Radix Aucklandiae.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
36 parts of 63 parts of Fructus Aurantii Immaturuss of 36 parts of Radix Et Rhizoma Rhei of Flos Carthami
36 parts on 63 parts of Pericarpium Citri Reticulatae Virides of 63 portions of Rhizoma Cyperis of Radix Angelicae Sinensis (vinegar system)
36 parts of 54 parts of Pericarpium Citri Reticulataes of 18 portions of Radix Curcumaes of Rhizoma Drynariae (processed with wine)
36 parts of 36 parts of Pollen Typhaes of 36 parts of Rhizoma Curcumae of Pseudobulbus Bletillae (Rhizoma Bletillae) (system)
36 parts of 36 parts of Radixs Linderae of 36 parts of Radix Saposhnikoviaes of Cortex Moutan
36 parts of rhizoma sparganic (system) 36 portions of Radix Aconitis of 36 parts of Radix Dipsacis (system)
18 parts of 27 parts of Fructus Amomis of 27 parts of Radix Clematidis of Oletum Trogopterori
18 parts in 36 portions of Radix Notoginsengs of 18 parts of Radix Paeoniae Rubra of the Radix Aucklandiae.
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, tablet, mixture, fluid extract and extractum, soft extract, powder.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Flos Carthami, Radix Et Rhizoma Rhei, Rhizoma Drynariae, Pollen Typhae (decocting a drug wrapped), the Radix Linderae, Radix Notoginseng medical material, soaked 30～90 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get Pseudobulbus Bletillae (Rhizoma Bletillae), rhizoma sparganic, Radix Dipsaci, Radix Aconiti, Oletum Trogopterori (decocting a drug wrapped), Radix Clematidis, Radix Paeoniae Rubra medical material, decoct with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, adopt steam distillation (or supercritical extraction); With the medical material chopping, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) taking technique 1. water carry medical material and directly beat powder and be used as medicine;
(2) all the other medical materials are handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and granule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) get Flos Carthami, Radix Et Rhizoma Rhei, Rhizoma Drynariae, Pollen Typhae (decocting a drug wrapped), the Radix Linderae, Radix Notoginseng medical material, soaked 30～90 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby.
(2) get Pseudobulbus Bletillae (Rhizoma Bletillae), rhizoma sparganic, Radix Dipsaci, Radix Aconiti, Oletum Trogopterori (decocting a drug wrapped), Radix Clematidis, Radix Paeoniae Rubra medical material, decoct with water 2～5 times, each 0.5～3 hour, collecting decoction filtered, and it is standby that filtrate is condensed into thick extractum;
(3) get the residue medical material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～12 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) taking technique 1. water carry medical material and directly beat powder and be used as medicine;
(2) all the other medical materials are handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610057279 CN1850264A (en) | 2006-03-10 | 2006-03-10 | Safflower preparation for treating wound and new preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610057279 CN1850264A (en) | 2006-03-10 | 2006-03-10 | Safflower preparation for treating wound and new preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101204474B (en) * | 2007-12-12 | 2010-12-15 | 王芳 | Tincture medicine for wrick |
| CN102274462A (en) * | 2011-08-08 | 2011-12-14 | 李静 | Traditional Chinese medicine ointment for treating traumatic sore |
| CN104147480A (en) * | 2014-07-17 | 2014-11-19 | 覃业宇 | Externally used traditional Chinese medicine (TCM) composition for relieving pains and preparation method thereof |
| CN107582932A (en) * | 2017-06-26 | 2018-01-16 | 安徽永生堂药业有限责任公司 | A kind of SHANGKE DIEDA PIAN and preparation method thereof |
-
2006
- 2006-03-10 CN CN 200610057279 patent/CN1850264A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101204474B (en) * | 2007-12-12 | 2010-12-15 | 王芳 | Tincture medicine for wrick |
| CN102274462A (en) * | 2011-08-08 | 2011-12-14 | 李静 | Traditional Chinese medicine ointment for treating traumatic sore |
| CN104147480A (en) * | 2014-07-17 | 2014-11-19 | 覃业宇 | Externally used traditional Chinese medicine (TCM) composition for relieving pains and preparation method thereof |
| CN104147480B (en) * | 2014-07-17 | 2017-12-12 | 覃业宇 | A kind of external medicine composition of analgesic and preparation method thereof |
| CN107582932A (en) * | 2017-06-26 | 2018-01-16 | 安徽永生堂药业有限责任公司 | A kind of SHANGKE DIEDA PIAN and preparation method thereof |
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