CN1775244A - Blood-cleaning detoxifying formulation and new preparing method - Google Patents
Blood-cleaning detoxifying formulation and new preparing method Download PDFInfo
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- CN1775244A CN1775244A CN 200510115976 CN200510115976A CN1775244A CN 1775244 A CN1775244 A CN 1775244A CN 200510115976 CN200510115976 CN 200510115976 CN 200510115976 A CN200510115976 A CN 200510115976A CN 1775244 A CN1775244 A CN 1775244A
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Abstract
The present invention relates to a Chinese medicine composition and its preparation process. In particular, it relates to a Chinese medicine prescription for curing the diseases of sore, furuncle, sore-throat, conjunctival congestion, canker sore and toothache and its preparation process. Said Chinese medicine composition can be made into dripping pills and soft capsule preparation.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind ofly be used for furuncle and fester the initial stage scorching hot heating and laryngopharynx swelling and pain, conjunctival congestion, aphtha, the prescription of toothache and preparation technology thereof.
Background technology:
Furuncle festers the initial stage, scorching hot heating and laryngopharynx swelling and pain, and conjunctival congestion, aphtha, toothache is clinical common sympton, and the traditional Chinese medical science is often taked heat-clearing and toxic substances removing, and the bullate means of emaciation due to emotional upset of loosing are treated it, and evident in efficacy, and the blood-cleaning detoxifying ball is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, mixture, its pill that makes can be used for curing mainly furuncle and festers the initial stage, scorching hot heating and laryngopharynx swelling and pain, conjunctival congestion, aphtha, toothache.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
25～266.5 parts of 25～266.5 parts of Herba Taraxacis of 50～533 portions of Herba Schizonepetae of Radix Et Rhizoma Rhei
25～266.5 parts of 25～266.5 parts of Radix Scutellariaes of 25～266.5 parts of Herba Corydalis Bungeanaes of Radix Saposhnikoviae
25～266.5 parts of 25～266.5 portions of Caulis Akebiaes of 25～266.5 portions of Radix Glycyrrhizaes of Fructus Forsythiae
25～266.5 parts of Radix Rehmanniae
Preferably:
50 parts of 50 parts of Herba Taraxacis of 100 portions of Herba Schizonepetae of Radix Et Rhizoma Rhei
50 parts of 50 parts of Radix Scutellariaes of 50 parts of Herba Corydalis Bungeanaes of Radix Saposhnikoviae
50 parts of 50 portions of Caulis Akebiaes of 50 portions of Radix Glycyrrhizaes of Fructus Forsythiae
50 parts of Radix Rehmanniae
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, mixture.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) get Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae, take supercritical extraction (or steam distillation), drop in the extraction kettle, when extraction kettle pressure reaches 25Mpa, the pressure of extraction-container I reaches 6Mpa, when extraction-container II pressure reaches 6Mpa, and beginning cycling extraction, CO
2Flow is about 20kg/h, from the extraction-container discharge hole for discharge, gets the yellow green oily liquids behind extraction 0.5～5h, and the volatile oil beta-cyclodextrin inclusion compound is standby;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule;
Method b:(technology 2.)
(1) getting Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae three flavor medical materials beats powder and is used as medicine;
(2) get prescription residue medical material, soaked 30～90 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to the influence of rat Ovum Gallus domesticus album foot swelling
Get 40 of healthy male white rats, be divided into 4 groups at random.Dosage and grouping see Table 1, before the experiment Ovum Gallus domesticus album 0.1ml injected to cause under the right back sufficient plantar aponeurosis of rat scorchingly not to compare to cause the scorching left back sufficient sole of the foot, with the difference of both sufficient sole of the foot girths as the swelling level index.Cause the scorching sufficient sole of the foot and be coated with medicine with prescribed dose.The results are shown in Table 1.As shown in Table 1, each extractum group and Anisodus carniolicoides C.Y.Wu et C.Chen are being coated with back 1 hour, and detumescence degree and matched group are relatively learned by statistics and handled difference not remarkable (P＞0.05).Behind the coating 1.5,2.0,2.5,3.0 hours, each extractum group caused the detumescence gradually of scorching foot, detumescence degree and matched group comparing difference highly significant (P＜0.01).
Table 1 pair Ovum Gallus domesticus album cause rat paw edema influence (x ± s, n=10)
| Group | Dosage (g/ only) | Cause scorching back different time (hour) foot swelling degree (mm) | ||||
| 1.0 | 1.5 | 2.0 | 2.5 | 3.0 | ||
| Matched group Anisodus carniolicoides C.Y.Wu et C.Chen technology is 2. extractum group of extractum group technology 1. | - 0.01 0.17 0.47 | 9.9±1.72 8.8±0.63 8.5±2.12 8.7±1.58 | 11.0±0.67 8.6 ±0.70 **8.8±1.39 **8.9±2.12 ** | 10.8±1.32 8.7±0.95 **8.2±1.03 **8.7±1.90 ** | 9.2±0.92 8.9±1.20 7.7±2.11 8.6±1.57 | 5.8±1.48 4.9±1.10 5.3±1.64 5.6±1.55 |
Compare with the blank group
*P＜0.05,
*P＜0.01 (down together)
2, to the influence of rat formaldehyde foot swelling
Get 40 of healthy male white rats, be divided into 4 groups at random, grouping and dosage see Table 2, will cause inflammation under the right back sufficient plantar aponeurosis of 2% formaldehyde 0.1ml injection rat before the experiment.Not causing scorching left side foot in contrast, with the difference of both sufficient sole of the foot girths as the swelling level index.Cause the scorching sufficient sole of the foot and be coated with, measured 1 time in 8,16,24,48,72 hours respectively at causing scorching back with medicine.1 medicine of repaste after every survey 1 time is coated with 5 times altogether, the results are shown in Table 2.
The influence of table 2 pair rat formaldehyde foot swelling (x ± s, n=10)
| Group | Dosage (g/ only) | Cause scorching back different time (hour) foot swelling degree (mm) | ||||
| 8 | 16 | 24 | 48 | 72 | ||
| Matched group Anisodus carniolicoides C.Y.Wu et C.Chen technology is 2. extractum group of extractum group technology 1. | - 0.01 0.17 0.47 | 9.4±1.53 8.9±1.70 8.5±1.91 8.7±1.82 | 1.07±1.23 9.1±2.23 **8.8±2.06 *9.0±2.42 | 11.9±1.89 9.8±1.22 ** 9.3±1.87 ** 9.6±1.93 * | 11.6±1.40 9.3±1.81 9.0±1.94** 9.1±2.10 ** | 11.4±1.92 9.1±1.57 8.9±1.63 ** 9.0±1.94 ** |
As shown in Table 2, technology 1. extractum just had the effect of obvious suppression rat foot swelling in 16 hours, and the effect that rat causes scorching foot swelling that suppresses was all arranged after 24 hours, difference highly significant or significantly (P＜0.01 or P＜0.05).
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are that a kind of good treatment furuncle festers the initial stage, scorching hot heating and laryngopharynx swelling and pain, conjunctival congestion, aphtha, the medicine of toothache, and change preparation technology can obviously strengthen its heat-clearing and toxic substances removing, the swollen clinical efficacy that waits of the emaciation due to emotional upset that looses, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Radix Et Rhizoma Rhei 133g Herba Schizonepetae 66.5g Herba Taraxaci 66.5g
Radix Saposhnikoviae 66.5g Herba Corydalis Bungeanae 66.5g Radix Scutellariae 66.5g
Fructus Forsythiae 66.5g Radix Glycyrrhizae 66.5g Caulis Akebiae 66.5g
Radix Rehmanniae 66.5g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) get Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae, take supercritical extraction (or steam distillation), drop in the extraction kettle, when extraction kettle pressure reaches 25Mpa, the pressure of extraction-container I reaches 6Mpa, when extraction-container II pressure reaches 6Mpa, and beginning cycling extraction, CO
2Flow is about 20kg/h, from the extraction-container discharge hole for discharge, gets the yellow green oily liquids behind the extraction 2.5h, and the volatile oil beta-cyclodextrin inclusion compound is standby;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Radix Et Rhizoma Rhei 533g Herba Schizonepetae 266.5g Herba Taraxaci 266.5g
Radix Saposhnikoviae 266.5g Herba Corydalis Bungeanae 266.5g Radix Scutellariae 266.5g
Fructus Forsythiae 266.5g Radix Glycyrrhizae 266.5g Caulis Akebiae 266.5g
Radix Rehmanniae 266.5g
PEG400 400g
Make 1000
Preparation method:
(1) get Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae, take supercritical extraction (or steam distillation), drop in the extraction kettle, when extraction kettle pressure reaches 25Mpa, the pressure of extraction-container I reaches 6Mpa, when extraction-container II pressure reaches 6Mpa, and beginning cycling extraction, CO
2Flow is about 20kg/h, from the extraction-container discharge hole for discharge, gets the yellow green oily liquids behind the extraction 2.5h, and the volatile oil beta-cyclodextrin inclusion compound is standby;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Radix Et Rhizoma Rhei 400g Herba Schizonepetae 200g Herba Taraxaci 200g
Radix Saposhnikoviae 200g Herba Corydalis Bungeanae 200g Radix Scutellariae 200g
Fructus Forsythiae 200g Radix Glycyrrhizae 200g Caulis Akebiae 200g
Radix Rehmanniae 200g
Make 1000g
Preparation method:
(1) getting Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae three flavor medical materials beats powder and is used as medicine;
(2) get prescription residue medical material, soaked 60 minutes earlier with 65% ethanol, reheat refluxes and carries 3 times, and each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component is merged, add aspartame 5.0g, dextrin 150.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Radix Et Rhizoma Rhei 143g Herba Schizonepetae 71.5g Herba Taraxaci 71.5g
Radix Saposhnikoviae 71.5g Herba Corydalis Bungeanae 71.5g Radix Scutellariae 71.5g
Fructus Forsythiae 71.5g Radix Glycyrrhizae 71.5g Caulis Akebiae 71.5g
Radix Rehmanniae 71.5g
Make 1000
Preparation method:
(1) getting Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae three flavor medical materials beats powder and is used as medicine;
(2) get prescription residue medical material, soaked 60 minutes earlier with 65% ethanol, reheat refluxes and carries 3 times, and each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component is merged, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
25～266.5 parts of 25～266.5 parts of Herba Taraxacis of 50～533 portions of Herba Schizonepetae of Radix Et Rhizoma Rhei
25～266.5 parts of 25～266.5 parts of Radix Scutellariaes of 25～266.5 parts of Herba Corydalis Bungeanaes of Radix Saposhnikoviae
25～266.5 parts of 25～266.5 portions of Caulis Akebiaes of 25～266.5 portions of Radix Glycyrrhizaes of Fructus Forsythiae
25～266.5 parts of Radix Rehmanniae.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
50 parts of 50 parts of Herba Taraxacis of 100 portions of Herba Schizonepetae of Radix Et Rhizoma Rhei
50 parts of 50 parts of Radix Scutellariaes of 50 parts of Herba Corydalis Bungeanaes of Radix Saposhnikoviae
50 parts of 50 portions of Caulis Akebiaes of 50 portions of Radix Glycyrrhizaes of Fructus Forsythiae
50 parts of Radix Rehmanniae.
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, soft capsule, granule, chewable tablet, mixture.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae, take supercritical extraction (or steam distillation), drop in the extraction kettle, when extraction kettle pressure reaches 25Mpa, the pressure of extraction-container I reaches 6Mpa, when extraction-container II pressure reaches 6Mpa, and beginning cycling extraction, CO
2Flow is about 20kg/h, from the extraction-container discharge hole for discharge, gets the yellow green oily liquids behind extraction 0.5～5h, and the volatile oil beta-cyclodextrin inclusion compound is standby;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae three flavor medical materials beats powder and is used as medicine;
(2) get prescription residue medical material, soaked 30～90 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) get Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae, take supercritical extraction (or steam distillation), drop in the extraction kettle, when extraction kettle pressure reaches 25Mpa, the pressure of extraction-container I reaches 6Mpa, when extraction-container II pressure reaches 6Mpa, and beginning cycling extraction, CO
2Flow is about 20kg/h, from the extraction-container discharge hole for discharge, gets the yellow green oily liquids behind extraction 0.5～5h, and the volatile oil beta-cyclodextrin inclusion compound is standby;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into thick paste, promptly gets water extract;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Fructus Forsythiae, Radix Saposhnikoviae, Herba Schizonepetae three flavor medical materials beats powder and is used as medicine;
(2) get prescription residue medical material, soaked 30～90 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
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| CN 200510115976 CN1775244A (en) | 2005-11-18 | 2005-11-18 | Blood-cleaning detoxifying formulation and new preparing method |
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| CN 200510115976 CN1775244A (en) | 2005-11-18 | 2005-11-18 | Blood-cleaning detoxifying formulation and new preparing method |
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Cited By (3)
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| CN101584783B (en) * | 2008-05-20 | 2011-05-11 | 李振迎 | External medicine for treating infant thrush |
| CN103830607A (en) * | 2014-03-12 | 2014-06-04 | 张勇 | Traditional Chinese medicine for treating aphtha caused by accumulated heat of heart and spleen and upward attack of toxic heat and preparation method thereof |
| CN104258029A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Dropping pills with effects of diminishing inflammation, relieving pain and clearing heat from throat and preparation method thereof |
-
2005
- 2005-11-18 CN CN 200510115976 patent/CN1775244A/en active Pending
Cited By (3)
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| CN101584783B (en) * | 2008-05-20 | 2011-05-11 | 李振迎 | External medicine for treating infant thrush |
| CN103830607A (en) * | 2014-03-12 | 2014-06-04 | 张勇 | Traditional Chinese medicine for treating aphtha caused by accumulated heat of heart and spleen and upward attack of toxic heat and preparation method thereof |
| CN104258029A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Dropping pills with effects of diminishing inflammation, relieving pain and clearing heat from throat and preparation method thereof |
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