CN1824079A - Anti appendicitis preparation and its new preparation method - Google Patents
Anti appendicitis preparation and its new preparation method Download PDFInfo
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- CN1824079A CN1824079A CN 200610000762 CN200610000762A CN1824079A CN 1824079 A CN1824079 A CN 1824079A CN 200610000762 CN200610000762 CN 200610000762 CN 200610000762 A CN200610000762 A CN 200610000762A CN 1824079 A CN1824079 A CN 1824079A
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating acute or chronic appendicitis, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of prescription and preparation technology thereof who is used for acute and chronic appendicitis.
Background technology:
Acute and chronic appendicitis is clinically to see symptom more, and the traditional Chinese medical science is often taked heat-clearing and toxic substances removing, and the means of dissipating blood stasis for subsidence of swelling are treated it, and evident in efficacy.The anti appendicitis ball is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, mixture, its pill that makes can be used for treating acute and chronic appendicitis.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
15～750 parts of 15～750 parts of Herba Patriniae of 15～750 portions of Folium Isatidiss of Flos Lonicerae
5～150 parts of 15～750 parts of Fructus Toosendans of 15～750 portions of Caulis Spatholobis of Herba Taraxaci
7.5～225 parts of Radix Et Rhizoma Rhei 7.5～225 parts of Semen Benincasaes of 7.5～225 parts of Radix Aucklandiae (parched with bran)
7.5～225 parts of 10～300 parts of Radix Scutellariaes of 5～150 parts of Radix Paeoniae Rubra of Semen Persicae (peeling)
Preferably:
50 parts of 50 parts of Herba Patriniae of 50 portions of Folium Isatidiss of Flos Lonicerae
10 parts of 50 parts of Fructus Toosendans of 50 portions of Caulis Spatholobis of Herba Taraxaci
15 parts of Radix Et Rhizoma Rhei 15 parts of Semen Benincasaes of 15 parts of Radix Aucklandiae (parched with bran)
15 parts of 20 parts of Radix Scutellariaes of 10 parts of Radix Paeoniae Rubra of Semen Persicae (peeling)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, chewable tablet, mixture, soft extract, fluid extract and extractum.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) Six-element medical materials such as extracting honeysuckle, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Toosendan, the Radix Aucklandiae, Radix Paeoniae Rubra soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, and each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure became thick paste, and be standby;
(2) get the residue medical material, decoct with water 2～5 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 2～15 times of amount 50～95% ethanol, left standstill 5～72h, collected supernatant, and concentrating under reduced pressure promptly;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Radix Aucklandiae medical material beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, pharmacological research
1.1 the influence of white mice auricular concha inflammation due to the xylol
Get 40 of Kunming kind white mice, be divided into 4 groups at random, 10 every group, male and female half and half.Each group is pressed table 1 and is given 2 weeks of dosage continuous irrigation stomach, in last filling stomach after 1 hour, every white mice left side ear evenly is coated with dimethylbenzene and drips and cause inflammation, disconnected neck is put to death behind the 15min, cut auricular concha, get the auricle at bilateral ear symmetry place with diameter 7mm punching and weigh, represent the swelling degree with left and right sides auricle weight difference, ask inhibitory rate of intumesce, the results are shown in Table 1.
The influence of white mice auricular concha inflammation due to table 1 xylol (n=10, x ± SD)
| Group | Dosage (g/kg) | Swelling degree (mg) | Inhibitory rate of intumesce (%) |
| Matched group technology is 2. extractum group aspirin group of extractum group technology 1. | - 0.68 0.9 0.2 | 6.89±1.83 4.12±1.57 ** 4.64±1.28 ** 5.02±1.34 | 40.2 32.7 27.1 |
Annotate: compare with matched group,
*P＜0.05
By table 1 as seen, white mice auricular concha inflammation has the obvious suppression effect due to the medicine xylol; Relatively there is not significant difference with the aspirin group.
1.2 influence to the rat albumen arthritis
Get 40 of rat, be divided into 4 groups at random, 10 every group, male and female half and half.Be respectively 1. extractum group (0.34g/kg) of technology; Technology is extractum group (0.45g/kg) 2.; Blank group: give with the volume normal saline; Positive controls: aspirin 0.1g/kg presses table 2 to each group rat and gives 2 weeks of dosage successive administration (the only administration in the end 3 days of wherein positive group), after the last administration 1 hour, every right back ankle of rat, subcutaneous injection fresh albumen 0.1ml, inject back 0.5h, 1h, 2h, 3h, 4h, 5h measure ankle joint with tape girth respectively, difference with left and right sides ankle joint girth is the swollen joint expansibility, the results are shown in Table 2.
The influence of table 2 pair rat albumen arthritis (n=10, x ± SD)
| Group | Cause scorching back ankle swelling degree (mm) | |||||
| 0.5h | 1h | 2h | 3h | 4h | 5h | |
| Blank group technology is 2. extractum group aspirin group of extractum group technology 1. | 6.3±1.3 4.7±1.5 5.2±1.2 4.9±1.6 | 6.3±1.1 4.6±1.2 ** 4.7±1.1 ** 4.7±1.5 ** | 6.2±1.2 4.6±1.5 ** 4.6±1.2 ** 3.9±0.7 ** | 5.7±1.1 3.9±0.7 ** 4.3±0.8 ** 3.4±0.9 ** | 5.3±1.1 3.6±0.5 ** 3.5±0.9 ** 2.9±0.7 ** | 4.9±1.4 2.9±0.7 ** 2.9±0.6 ** 2.7±0.8 ** |
Annotate: compare with matched group,
*P＜0.05
By table 2 as seen, compare with the blank group, medicine has the obvious suppression effect to the rat albumen arthritis; Relatively there is not significant difference with the aspirin group.
1.3 the white mice hot plate is caused the inhibitory action of pain
Get 40 of Kunming kind white mice, be divided into 4 groups at random, 10 every group, male and female half and half.Be respectively 1. extractum group of technology; Technology is the extractum group 2.; Blank group: normal saline 0.8ml/ only; Positive controls: aspirin 0.2g/kg.Each organizes 2 weeks of successive administration, after 1 hour, surveys its pain threshold with hot plate method in the last administration, relatively the analgesia percentage rate of each treated animal.(pain threshold before analgesia percentage rate=(the preceding pain threshold of pain threshold-administration after the administration)/administration) the results are shown in Table 3.
Table 3 pair white mice hot plate causes inhibitory action (n=10, the x ± SD) of pain
| Group | Dosage (g/kg) | Pain threshold (S) before the administration | Pain threshold after the administration (S) | Analgesia percentage rate (%) |
| Blank group technology is 2. extractum group aspirin group of extractum group technology 1. | - 0.68 0.9 0.2 | 10.5±5.4 11.2±4.3 11.3±4.5 11.2±3.8 | 11.3±5.2 20.2±8.9 19.1±9.2 13.3±5.7 | 7.62 80.36 ** 0.69 ** 0.20 ** |
By table 3 as seen, medicine has certain analgesic activity to the white mice in the hot plate method experiment, does not relatively have significant difference with the aspirin group.
2, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of medicines of good treatment acute and chronic appendicitis, and change preparation technology can obviously strengthen its heat-clearing and toxic substances removing, clinical efficacies such as dissipating blood stasis for subsidence of swelling, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Flos Lonicerae 135g Folium Isatidis 135g Herba Patriniae 135g
Herba Taraxaci 135g Caulis Spatholobi 135g Fructus Toosendan 27g
Radix Et Rhizoma Rhei 40.5g Radix Aucklandiae 40.5g Semen Benincasae (parched with bran) 40.5g
Semen Persicae (peeling) 27g Radix Paeoniae Rubra 54g Radix Scutellariae 40.5g
PEG4000 00g
Make 1000 balls
Preparation method:
(1) Six-element medical materials such as extracting honeysuckle, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Toosendan, the Radix Aucklandiae, Radix Paeoniae Rubra soaked 30 minutes earlier with 85% ethanol, reheat reflux, extract, 3 times, and each 1 hour, merge extractive liquid,, concentrating under reduced pressure became thick paste, and be standby;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 8 times of amount 95% ethanol, left standstill 24h, collected supernatant, and concentrating under reduced pressure promptly;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Flos Lonicerae 750g Folium Isatidis 750g Herba Patriniae 750g
Herba Taraxaci 750g Caulis Spatholobi 750g Fructus Toosendan 150g
Radix Et Rhizoma Rhei 225g Radix Aucklandiae 225g Semen Benincasae (parched with bran) 225g
Semen Persicae (peeling) 150g Radix Paeoniae Rubra 300g Radix Scutellariae 225g
PEG400 550g
Make 1000
Preparation method:
(1) Six-element medical materials such as extracting honeysuckle, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Toosendan, the Radix Aucklandiae, Radix Paeoniae Rubra soaked 30 minutes earlier with 85% ethanol, reheat reflux, extract, 3 times, and each 1 hour, merge extractive liquid,, concentrating under reduced pressure became thick paste, and be standby;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 8 times of amount 95% ethanol, left standstill 24h, collected supernatant, and concentrating under reduced pressure promptly;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Flos Lonicerae 750g Folium Isatidis 750g Herba Patriniae 750g
Herba Taraxaci 750g Caulis Spatholobi 750g Fructus Toosendan 150g
Radix Et Rhizoma Rhei 225g Radix Aucklandiae 225g Semen Benincasae (parched with bran) 225g
Semen Persicae (peeling) 150g Radix Paeoniae Rubra 300g Radix Scutellariae 225g
Make 1000g
Preparation method:
(1) getting Radix Aucklandiae medical material beats powder and is used as medicine;
(2) five tastes medical materials such as extracting honeysuckle, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Toosendan, Radix Paeoniae Rubra soaked 30 minutes earlier with 85% ethanol, reheat reflux, extract, 3 times, and each 1 hour, merge extractive liquid,, concentrating under reduced pressure became thick paste, and be standby;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 8 times of amount 95% ethanol, left standstill 24h, collected supernatant, and concentrating under reduced pressure promptly;
(4) above active component is merged, add aspartame 5.0g, dextrin 250.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Flos Lonicerae 500g Folium Isatidis 500g Herba Patriniae 500g
Herba Taraxaci 500g Caulis Spatholobi 500g Fructus Toosendan 100g
Radix Et Rhizoma Rhei 150g Radix Aucklandiae 150g Semen Benincasae (parched with bran) 150g
Semen Persicae (peeling) 100g Radix Paeoniae Rubra 200g Radix Scutellariae 150g
Make 1000
Preparation method:
(1) getting Radix Aucklandiae medical material beats powder and is used as medicine;
(2) five tastes medical materials such as extracting honeysuckle, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Toosendan, Radix Paeoniae Rubra soaked 30 minutes earlier with 85% ethanol, reheat reflux, extract, 3 times, and each 1 hour, merge extractive liquid,, concentrating under reduced pressure became thick paste, and be standby;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 8 times of amount 95% ethanol, left standstill 24h, collected supernatant, and concentrating under reduced pressure promptly;
(4) above active component is merged, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
15～750 parts of 15～750 parts of Herba Patriniae of 15～750 portions of Folium Isatidiss of Flos Lonicerae
5～150 parts of 15～750 parts of Fructus Toosendans of 15～750 portions of Caulis Spatholobis of Herba Taraxaci
7.5～225 parts of Radix Et Rhizoma Rhei 7.5～225 parts of Semen Benincasaes of 7.5～225 parts of Radix Aucklandiae (parched with bran)
7.5～225 parts of 10～300 parts of Radix Scutellariaes of 5～150 parts of Radix Paeoniae Rubra of Semen Persicae (peeling).
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
50 parts of 50 parts of Herba Patriniae of 50 portions of Folium Isatidiss of Flos Lonicerae
10 parts of 50 parts of Fructus Toosendans of 50 portions of Caulis Spatholobis of Herba Taraxaci
15 parts of Radix Et Rhizoma Rhei 15 parts of Semen Benincasaes of 15 parts of Radix Aucklandiae (parched with bran)
15 parts of 20 parts of Radix Scutellariaes of 10 parts of Radix Paeoniae Rubra of Semen Persicae (peeling).
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, chewable tablet, mixture, soft extract, fluid extract and extractum.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) Six-element medical materials such as extracting honeysuckle, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Toosendan, the Radix Aucklandiae, Radix Paeoniae Rubra soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, and each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure became thick paste, and be standby;
(2) get the residue medical material, decoct with water 2～5 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 2～15 times of amount 50～95% ethanol, left standstill 5～72h, collected supernatant, and concentrating under reduced pressure promptly;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Radix Aucklandiae medical material beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) Six-element medical materials such as extracting honeysuckle, Radix Et Rhizoma Rhei, Radix Scutellariae, Fructus Toosendan, the Radix Aucklandiae, Radix Paeoniae Rubra soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, and each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure became thick paste, and be standby;
(2) get the residue medical material, decoct with water 2～5 times, each 0.5～3.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 2～15 times of amount 50～95% ethanol, left standstill 5～72h, collected supernatant, and concentrating under reduced pressure promptly;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Radix Aucklandiae medical material beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as tablet of the present invention and capsule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610000762 CN1824079A (en) | 2006-01-12 | 2006-01-12 | Anti appendicitis preparation and its new preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610000762 CN1824079A (en) | 2006-01-12 | 2006-01-12 | Anti appendicitis preparation and its new preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895644A (en) * | 2012-10-22 | 2013-01-30 | 邹恩芹 | Chinese medicinal external application powder for treating acute appendicitis |
| CN103393789A (en) * | 2013-05-31 | 2013-11-20 | 青岛国风药业股份有限公司 | Medicinal composition for treating pelvic inflammations, and preparation method and new use thereof |
| CN105213507A (en) * | 2015-10-13 | 2016-01-06 | 全运明 | One treats typhlitic Chinese medicine composition |
-
2006
- 2006-01-12 CN CN 200610000762 patent/CN1824079A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895644A (en) * | 2012-10-22 | 2013-01-30 | 邹恩芹 | Chinese medicinal external application powder for treating acute appendicitis |
| CN102895644B (en) * | 2012-10-22 | 2013-10-30 | 邹恩芹 | Chinese medicinal external application powder for treating acute appendicitis |
| CN103393789A (en) * | 2013-05-31 | 2013-11-20 | 青岛国风药业股份有限公司 | Medicinal composition for treating pelvic inflammations, and preparation method and new use thereof |
| CN105213507A (en) * | 2015-10-13 | 2016-01-06 | 全运明 | One treats typhlitic Chinese medicine composition |
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