CN1824101A - Xingsuerchen medicinal preparation and its new preparation method - Google Patents
Xingsuerchen medicinal preparation and its new preparation method Download PDFInfo
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating cold, headache and cold caused cough, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of anemofrigid cold that is used for, the prescription and the preparation technology thereof of the cough that nasal obstruction headache and affection of exogenous wind-cold cause.
Background technology:
Anemofrigid cold, the cough that nasal obstruction headache and affection of exogenous wind-cold cause is clinical common sympton, the traditional Chinese medical science is often taked dispelling wind to relieve the exterior syndrome, preventing phlegm from forming and stopping coughing, the means of the Shu Yu that regulates the flow of vital energy are treated it, and evident in efficacy, and the Xingsuerchen medicinal ball is that it represents medicine.But in the practice, because this medicine is the part medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, its pill that makes can be used for curing mainly anemofrigid cold, the cough that nasal obstruction headache and affection of exogenous wind-cold cause.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
120～600 parts of 120～600 parts of Pericarpium Citri Reticulataes of 40～200 parts of Folium Perillaes of Semen Armeniacae Amarum
80～400 parts in 80～400 parts of Poria of 80～400 parts of Radix Platycodoniss of Radix Peucedani
40～200 parts in 120～600 portions of Radix Glycyrrhizaes of the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) (processing)
Preferably:
300 parts of 300 parts of Pericarpium Citri Reticulataes of 100 parts of Folium Perillaes of Semen Armeniacae Amarum
200 parts in 200 parts of Poria of 200 parts of Radix Platycodoniss of Radix Peucedani
100 parts in 300 portions of Radix Glycyrrhizaes of the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) (processing)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, pill, powder, soft extract, syrup, fluid extract and extractum.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) gets Radix Peucedani, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Folium Perillae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue that remains medical material and (1), soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Semen Armeniacae Amarum, Radix Glycyrrhizae two flavor medical materials beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of hard capsule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, and drying, mixing is filled and is promptly got hard capsule.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, phlegm-dispelling functions (the phenol red method of trachea section)
Get body weight and be 60 of the Kunming mouses of 20 ± 3g, male and female half and half, laboratory adapts to 3d, is divided into 4 groups at random by sex, body weight, 15 every group, is respectively 1. 2. extractum group of extractum group and technology of normal saline matched group, Radix Polygalae decoct matched group, technology.Irritate the corresponding medicinal liquid of stomach respectively, every day 1 time, 7d continuously.0.5h after the last administration, each organizes the phenol red normal saline 0.1ml/10g of the equal lumbar injection 5% of mice, animal is put to death in dislocation behind the 30min, peel off the trachea surrounding tissue, cut one section trachea down to the trachea crotch from thyroid cartilage, put into the test tube that fills the 2ml normal saline, add the sodium hydroxide of 0.1ml5% again.With 722 type spectrophotometers, survey the OD value at wavelength 540nm place, with the phenol red standard curve of doing, calculate phenol red content (μ g/ml) according to standard curve, the results are shown in Table 1.
Table 1 phlegm-dispelling functions (n=15, x ± s)
| Group | Dosage (g/kg) | The phenol red excretion amount of trachea (ρ/μ gml -1) |
| Normal control group Radix Polygalae water decoction group technology is 2. extractum group of extractum group technology 1. | - 1 0.37 0.62 | 0.071±0.04 0.251±0.13 *** 0.197±0.16 ** 0.181±0.03 *** |
Annotate: with the contrast of normal control group,
*P＜0.01,
* *P＜0.001
By table 1 as seen, the extractum group all has the phenol red effect of the trachea excretion of enhancing.
2, antiinflammatory action (Oleum Tiglii causes the mice ear method)
Get 64 of Kunming mouses, laboratory adapts to 3d, is divided into 4 groups at random by sex, body weight.Every group 16, be respectively 1. 2. extractum group of extractum group and technology of normal saline matched group, aspirin matched group, technology, irritate the corresponding medicinal liquid of stomach (seeing Table 2) respectively, every day 1 time, 7d continuously.1h after the last administration, each is organized mice and all smears the auris dextra inboard with 2% Oleum Tiglii 0.02ml, behind the 3h mice dislocation is put to death.Cut ears,, get auricle from two ear same area with the 7mm card punch, scales/electronic balance weighing, and represent the swelling degree, the results are shown in Table 2 with swelling rate=(auris dextra sheet heavy-left auricle is heavy)/left auricle heavy * 100%.
The antiinflammatory action of table 2 pair mice ear (n=16, x ± s)
| Group | Dosage (g/kg) | Swelling rate (%) |
| Normal control group aspirin group technology is 2. extractum group of extractum group technology 1. | - 0.2 0.37 0.62 | 122.79±40.36 72.18±52.71 * 75.83±38.44 * 77.92±38.68 * |
Annotate: with the contrast of normal control group,
*P＜0.05
By table 2 as seen, the extractum group has remarkable inhibitory action (P＜0.05) to Oleum Tiglii induced mice ear swelling,
3, antitussive effect
40 of Kunming mouses getting body weight and be 20 ± 3g are divided into 4 groups at random, and 10 every group, male and female half and half are respectively 1. 2. extractum group of extractum group and technology of normal saline matched group, positive drug pentoxyverine matched group, technology.The corresponding medicinal liquid of the disposable filling stomach of difference, 1h after administration carries out the antitussive experiment.During experiment respectively with each group mice by only putting into bell glass, the cover infantile tic has a filter paper, and (2cm * 2cm) is with 0.3ml ammonia (25%～28%NH
4OH), being added to stimulates mice on the filter paper, continues to stimulate 30s, takes out the cough number of times in mice observation and record mouse cough incubation period and the 2min, the results are shown in Table 3.
Table 3 pair ammonia causes influence (n=10, the x ± s) of mouse cough
| Group | Dosage (g/kg) | Cough latent period (t/min) | Cough number of times/2min |
| Normal control group pentoxyverine group technology is 2. extractum group of extractum group technology 1. | - 0.017mg/kg 0.37 0.62 | 0.26±0.21 1.11±0.69 0.93±0.52 0.47±0.23 | 14.17±4.33 6.82±4.63 * 6.41±3.57 * 8.65±529 |
Annotate: with the contrast of normal control group,
*P＜0.05
By table 3 as seen, technology is extractum group mouse cough significant prolongation incubation period (P＜0.05) 1., and the cough number of times significantly reduces (P＜0.05).Show that the cough that medicine causes chemical stimulation has certain antitussive effect.
4, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity: hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment anemofrigid cold, the medicine of the cough that nasal obstruction headache and affection of exogenous wind-cold cause, and change preparation technology, can obviously strengthen its dispelling wind to relieve the exterior syndrome, preventing phlegm from forming and stopping coughing, the clinical efficacies such as Shu Yu of regulating the flow of vital energy, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Semen Armeniacae Amarum 40g Folium Perillae 120g Pericarpium Citri Reticulatae 120g
Radix Peucedani 80g Radix Platycodonis 80g Poria 80g
The Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 120g Radix Glycyrrhizae (processing) 40g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) gets Radix Peucedani, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Folium Perillae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(2) get the residue that remains medical material and (1), soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Semen Armeniacae Amarum 180g Folium Perillae 540g Pericarpium Citri Reticulatae 540g
Radix Peucedani 360g Radix Platycodonis 360g Poria 360g
The Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 540g Radix Glycyrrhizae (processing) 180g
PEG400 450g
Make 1000
Preparation method:
(1) gets Radix Peucedani, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Folium Perillae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(2) get the residue that remains medical material and (1), soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Semen Armeniacae Amarum 200g Folium Perillae 600g Pericarpium Citri Reticulatae 600g
Radix Peucedani 400g Radix Platycodonis 400g Poria 400g
The Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 600g Radix Glycyrrhizae (processing) 200g
Make 1000g
Preparation method:
(1) gets Radix Peucedani, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Folium Perillae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(2) getting Semen Armeniacae Amarum, Radix Glycyrrhizae two flavor medical materials beats powder and is used as medicine;
(3) get the residue that remains medical material and (1), soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(4) above active component is merged, add aspartame 5.0g, dextrin 150.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of hard capsule of the present invention:
Prescription:
Semen Armeniacae Amarum 120g Folium Perillae 360g Pericarpium Citri Reticulatae 360g
Radix Peucedani 240g Radix Platycodonis 240g Poria 240g
The Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 360g Radix Glycyrrhizae (processing) 120g
Make 1000
Preparation method:
(1) gets Radix Peucedani, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Folium Perillae four Chinese medicine material, adopt steam distillation (or supercritical extraction):, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height the medical material chopping; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 8 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(2) getting Semen Armeniacae Amarum, Radix Glycyrrhizae two flavor medical materials beats powder and is used as medicine;
(3) get the residue that remains medical material and (1), soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(4) above active component is merged, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, and mixing is filled, and promptly gets 1000 of capsules.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
120～600 parts of 120～600 parts of Pericarpium Citri Reticulataes of 40～200 parts of Folium Perillaes of Semen Armeniacae Amarum
80～400 parts in 80～400 parts of Poria of 80～400 parts of Radix Platycodoniss of Radix Peucedani
40～200 parts in 120～600 portions of Radix Glycyrrhizaes of the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) (processing).
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
300 parts of 300 parts of Pericarpium Citri Reticulataes of 100 parts of Folium Perillaes of Semen Armeniacae Amarum
200 parts in 200 parts of Poria of 200 parts of Radix Platycodoniss of Radix Peucedani
100 parts in 300 portions of Radix Glycyrrhizaes of the Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) (processing).
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, tablet, mixture, pill, powder, soft extract, syrup, fluid extract and extractum.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Radix Peucedani, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Folium Perillae four Chinese medicine material, adopt steam distillation (or supercritical extraction):
With the medical material chopping, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue that remains medical material and (1), soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Semen Armeniacae Amarum, Radix Glycyrrhizae two flavor medical materials beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of hard capsule is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, mixing is filled and is promptly got hard capsule.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) get Radix Peucedani, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Folium Perillae four Chinese medicine material, adopt steam distillation (or supercritical extraction):
With the medical material chopping, extract according to an appendix XD of pharmacopeia in 2005 essential oil extraction method, till no longer increasing to the volatile oil height; The volatile oil β-CDBao He, optimised process is: β-CD is 1: 6～10 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～70min gets clathrate;
(2) get the residue that remains medical material and (1), soaked 30～60 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting Semen Armeniacae Amarum, Radix Glycyrrhizae two flavor medical materials beats powder and is used as medicine;
(2) the residue medical material is handled the same.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755975A (en) * | 2010-01-25 | 2010-06-30 | 中山市新运来医药科技开发有限公司大涌分公司 | Chinese herbal medicine sugar and tea drink preparation for preventing and treating cold |
| CN104587164A (en) * | 2014-12-25 | 2015-05-06 | 陆莎 | traditional Chinese medicine mixture for treating multiple coughs |
| CN105311290A (en) * | 2014-06-04 | 2016-02-10 | 兰州大学 | Use of Erchen pill prescription in preparation of drug for resisting aging |
| CN109224016A (en) * | 2018-11-27 | 2019-01-18 | 何雁玲 | A kind of relieving cough and reducing sputum cream of external application and preparation method thereof |
| CN113599445A (en) * | 2021-08-26 | 2021-11-05 | 河南合智医药科技有限公司 | Sugar-free apricot kernel and perilla cold granules and preparation method thereof |
| CN116672327A (en) * | 2023-05-31 | 2023-09-01 | 海南钧华医疗科技有限公司 | Apricot and perilla cough-relieving cataplasm acupoint patch and preparation method thereof |
-
2005
- 2005-12-15 CN CN 200510134441 patent/CN1824101A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101755975A (en) * | 2010-01-25 | 2010-06-30 | 中山市新运来医药科技开发有限公司大涌分公司 | Chinese herbal medicine sugar and tea drink preparation for preventing and treating cold |
| CN105311290A (en) * | 2014-06-04 | 2016-02-10 | 兰州大学 | Use of Erchen pill prescription in preparation of drug for resisting aging |
| CN104587164A (en) * | 2014-12-25 | 2015-05-06 | 陆莎 | traditional Chinese medicine mixture for treating multiple coughs |
| CN109224016A (en) * | 2018-11-27 | 2019-01-18 | 何雁玲 | A kind of relieving cough and reducing sputum cream of external application and preparation method thereof |
| CN113599445A (en) * | 2021-08-26 | 2021-11-05 | 河南合智医药科技有限公司 | Sugar-free apricot kernel and perilla cold granules and preparation method thereof |
| CN116672327A (en) * | 2023-05-31 | 2023-09-01 | 海南钧华医疗科技有限公司 | Apricot and perilla cough-relieving cataplasm acupoint patch and preparation method thereof |
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