CN1775246A - Preparation for treating breast sore and new preparing method - Google Patents
Preparation for treating breast sore and new preparing method Download PDFInfo
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- CN1775246A CN1775246A CNA2005101159834A CN200510115983A CN1775246A CN 1775246 A CN1775246 A CN 1775246A CN A2005101159834 A CNA2005101159834 A CN A2005101159834A CN 200510115983 A CN200510115983 A CN 200510115983A CN 1775246 A CN1775246 A CN 1775246A
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Abstract
The present invention relates to a Chinese medicine comosition and its preparation process. In particular, it relates to a Chinese medicine prescription for curing the diseases of mammitis, mammary swelling, large carbuncle and nodules of breast, etc. and its preparation process. Said Chinese medicine composition can be made into dripping pills and soft capsule preparation.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of treatment breast ulcer, carbuncle from the beginning of, scorching hot have a pain hard prescription that does not disappear and preparation technology thereof.
Background technology:
Breast ulcer is exactly mastitis, and breast is inner to be caused owing to pathogenic bacterium enter.Mastitis have individual evolution, and the nipple laceration is the door that enters of antibacterial often.Often adopt the breast ulcer ball to treat clinically, but the practice in since its be common water pill, dosage is big, onset is slow, has a strong impact on its application clinically.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, capsule, tablet, mixture, its pill that makes can be used for curing mainly breast ulcer, carbuncle from the beginning of, scorching hot have a pain hardly do not disappear.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
75～600 parts of 125～1000 parts of Radix Trichosanthis of 125～1000 parts of Herba Taraxacis of Flos Lonicerae
50～400 parts on 50～400 parts of Pericarpium Citri Reticulatae Virides of Squama Manis (system) 50～400 parts of Myrrhas (vinegar system) (vinegar system)
75～600 parts of 100～800 parts of Radix Paeoniae Rubra of 125～1000 parts of Radix Angelicae Sinensis of Fructus Forsythiae (vinegar system)
50～400 parts of 50～400 parts of Rhizoma Chuanxiongs of 50～400 portions of Radix Rehmanniae of Olibanum (vinegar system)
Preferably:
150 parts of 250 parts of Radix Trichosanthis of 250 parts of Herba Taraxacis of Flos Lonicerae
100 parts on 100 parts of Pericarpium Citri Reticulatae Virides of Squama Manis (system) 100 parts of Myrrhas (vinegar system) (vinegar system)
150 parts of 200 parts of Radix Paeoniae Rubra of 250 parts of Radix Angelicae Sinensis of Fructus Forsythiae (vinegar system)
100 parts of 100 parts of Rhizoma Chuanxiongs of 100 portions of Radix Rehmanniae of Olibanum (vinegar system)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, mixture, capsule etc.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) gets Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0～4.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating III), and 34.8 ℃ (separating m) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 6～14 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～180min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material are handled the same;
(2) get prescription residue medical material, soaked 30～180 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
2, antiinflammatory action
Get 32 of rats, be divided into 4 groups at random, 8 every group.Be blank, and the dexamethasone sodium phosphate injection positive control (DS, 5mg/kg), technology is extractum group (0.19g/kg) 1., and technology is extractum group (0.31g/kg) 2..Each is organized rat and all uses pentobarbital sodium 35mg/kg intraperitoneal injection of anesthesia, cuts an osculum that is about 1cm at the both sides of every Mus groin, and it is subcutaneous that every side is put into incision with the aseptic cotton balls (the ampicillin 0.2ml that adds 10u/ml) of 30mg, skin suture.From performing the operation the same day, each organizes administration respectively, and the blank group is given equal-volume normal saline filling stomach, every day 1 time, continuous 6 days.Postoperative the 7th day takes out the cotton balls granulation tissue, weighs behind 60 ℃ of oven dry 12h, deducts dry cotton ball weight and promptly gets granuloma weight.Then according to body weight, calculate the granuloma weight I1J of every 100s body weight again.The result shows that each extractum group is implanted cotton balls formation granuloma to subcutaneous rat obvious inhibitory action (P＜0.01).The results are shown in Table 1.
The granulomatous influence of formation behind the table 1 pair subcutaneous rat implantation cotton balls (x ± s)
| Group | Number of animals (only) | Dosage (g/kg) | Granuloma heavy (mg/100g) |
| Matched group technology is 2. extractum group DS of extractum group technology 1. | 8 8 8 8 | - 0.19 0.31 0.005 | 85.2±11.6 51.8±14.2 ** 53.1±11.4 ** 37.4±14.4 ** |
Compare with the blank group
*P＜0.05,
*P＜0.01 (down together)
2, analgesic activity
Choose 40 of mices, body weight 16～20g, male and female have concurrently, are divided into 4 groups at random, and according to last method administration, wherein positive controls irritates stomach for aspirin 0.3g/kg.1 day 1 time, continuous 5 days, after the last administration behind the 1h, each Mus lumbar injection 0.5% acetum 0.2ml.Observe and write down the number of times of the hemorrhage writhing response of each mice in 15 minutes (abdominal part indent, stretching, extension hind leg, buttocks are raised).The result shows that each extractum can make the mouse writhing reaction times obviously reduce (P＜0.01), the results are shown in Table 2.
Table 2 pair ip in mice 0.5% acetum causes the influence (x ± s) of writhing response
| Group | Number of animals (only) | Dosage (g/kg) | The writhing response number of times |
| Matched group technology is 2. extractum group aspirin of extractum group technology 1. | 10 10 10 10 | - 0.38 0.62 0.30 | 33±5 9±5 ** 10±7 ** 8±6 ** |
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are a kind of good treatment breast ulcer, carbuncle from the beginning of, the scorching hot hard medicine that does not disappear of having a pain, and change preparation technology can obviously strengthen its removing toxic substances and promoting subsidence of swelling, clinical efficacies such as anti-inflammatory analgetic, its hypotoxicity in addition, therefore prolonged application safety, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Flos Lonicerae 200g Herba Taraxaci 200g Radix Trichosanthis 120g
Squama Manis (system) 80g Myrrha (vinegar system) 80g Pericarpium Citri Reticulatae Viride (vinegar system) 80g
Fructus Forsythiae (vinegar system) 200g Radix Angelicae Sinensis 160g Radix Paeoniae Rubra 120g
Olibanum (vinegar system) 80g Radix Rehmanniae 80g Rhizoma Chuanxiong 80g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) gets Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0～4.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating III), and 34.8 ℃ (separating m) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 10 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 12h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Flos Lonicerae 600g Herba Taraxaci 600g Radix Trichosanthis 360g
Squama Manis (system) 240g Myrrha (vinegar system) 240g Pericarpium Citri Reticulatae Viride (vinegar system) 240g
Fructus Forsythiae (vinegar system) 600g Radix Angelicae Sinensis 480g Radix Paeoniae Rubra 360g
Olibanum (vinegar system) 240g Radix Rehmanniae 240g Rhizoma Chuanxiong 240g
PEG400 300g
Make 1000
Preparation method:
(1) gets Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0～4.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating III), and 34.8 ℃ (separating m) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 10 with the water ratio, and oil is 1: 8 with β-CD ratio, and ultrasonic 40min gets clathrate;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 12h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Flos Lonicerae 1000g Herba Taraxaci 1000g Radix Trichosanthis 600g
Squama Manis (system) 400g Myrrha (vinegar system) 400g Pericarpium Citri Reticulatae Viride (vinegar system) 400g
Fructus Forsythiae (vinegar system) 1000g Radix Angelicae Sinensis 800g Radix Paeoniae Rubra 600g
Olibanum (vinegar system) 400g Radix Rehmanniae 400g Rhizoma Chuanxiong 400g
Make 1000g
Preparation method:
(1) Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material are handled the same;
(2) get prescription residue medical material, soaked 60 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component is merged, add aspartame 5.0g, dextrin 180.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Flos Lonicerae 307.5g Herba Taraxaci 307.5g Radix Trichosanthis 184.5g
Squama Manis (system) 123g Myrrha (vinegar system) 123g Pericarpium Citri Reticulatae Viride (vinegar system) 123g
Fructus Forsythiae (vinegar system) 307.5g Radix Angelicae Sinensis 246g Radix Paeoniae Rubra 184.5g
Olibanum (vinegar system) 123g Radix Rehmanniae 123g Rhizoma Chuanxiong 123g
Make 1000
Preparation method:
(1) Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material are handled the same;
(2) get prescription residue medical material, soaked 60 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component is merged, add aspartame 3.0g, mannitol 250.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
75～600 parts of 125～1000 parts of Radix Trichosanthis of 125～1000 parts of Herba Taraxacis of Flos Lonicerae
50～400 parts on 50～400 parts of Pericarpium Citri Reticulatae Virides of Squama Manis (system) 50～400 parts of Myrrhas (vinegar system) (vinegar system)
75～600 parts of 100～800 parts of Radix Paeoniae Rubra of 125～1000 parts of Radix Angelicae Sinensis of Fructus Forsythiae (vinegar system)
50～400 parts of 50～400 parts of Rhizoma Chuanxiongs of 50～400 portions of Radix Rehmanniae of Olibanum (vinegar system).
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
150 parts of 250 parts of Radix Trichosanthis of 250 parts of Herba Taraxacis of Flos Lonicerae
100 parts on 100 parts of Pericarpium Citri Reticulatae Virides of Squama Manis (system) 100 parts of Myrrhas (vinegar system) (vinegar system)
150 parts of 200 parts of Radix Paeoniae Rubra of 250 parts of Radix Angelicae Sinensis of Fructus Forsythiae (vinegar system)
100 parts of 100 parts of Rhizoma Chuanxiongs of 100 portions of Radix Rehmanniae of Olibanum (vinegar system).
3, claim 1 or any one Chinese medicine preparation of 2 are various suitable dosage forms such as drop pill, soft capsule, granule, chewable tablet, mixture, capsule.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) gets Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0～4.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating III), and 34.8 ℃ (separating m) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 6～14 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～180min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material are handled the same;
(2) get prescription residue medical material, soaked 30～180 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) gets Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material, adopt supercritical extraction (or steam distillation): in the supercritical extraction jar of packing into, be that 20MPa, temperature are to extract 3.0～4.0h under 40 ℃, the condition of flow 20L/h with pressure; With pressure is 5.5MPa, and temperature is 34.5 ℃ (separating III), and 34.8 ℃ (separating m) resolve, and get extract; β-CDBao He, optimised process is: β-CD is 1: 6～14 with the water ratio, and oil is 1: 4～12 with β-CD ratio, and ultrasonic 30～180min gets clathrate;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～4 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 6～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) Radix Angelicae Sinensis, Olibanum, Myrrha, Fructus Forsythiae, Rhizoma Chuanxiong five tastes medical material are handled the same;
(2) get prescription residue medical material, soaked 30～180 minutes earlier with 50～85% ethanol, reheat reflux, extract, 2～6 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention.
This active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101159834A CN1775246A (en) | 2005-11-18 | 2005-11-18 | Preparation for treating breast sore and new preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101159834A CN1775246A (en) | 2005-11-18 | 2005-11-18 | Preparation for treating breast sore and new preparing method |
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| Publication Number | Publication Date |
|---|---|
| CN1775246A true CN1775246A (en) | 2006-05-24 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005101159834A Pending CN1775246A (en) | 2005-11-18 | 2005-11-18 | Preparation for treating breast sore and new preparing method |
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| CN (1) | CN1775246A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068548B (en) * | 2009-11-19 | 2012-03-07 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Determination method of sore breast pill for treating sore breast |
| CN102526557A (en) * | 2012-02-15 | 2012-07-04 | 李新民 | Oral medicinal composition for treating breast diseases and preparation method thereof |
| CN104173463A (en) * | 2013-05-23 | 2014-12-03 | 任相生 | Externally applied traditional Chinese medicine for treating lymph node and thyroid |
| CN104758709A (en) * | 2015-04-28 | 2015-07-08 | 张景悦 | Traditional Chinese medicine ointment for treating breast pain and insomnia for acute mastitis patient with abscess |
| CN104857126A (en) * | 2015-06-04 | 2015-08-26 | 夏征梅 | Traditional Chinese medicine composition for treating mammitis |
-
2005
- 2005-11-18 CN CNA2005101159834A patent/CN1775246A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068548B (en) * | 2009-11-19 | 2012-03-07 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Determination method of sore breast pill for treating sore breast |
| CN102526557A (en) * | 2012-02-15 | 2012-07-04 | 李新民 | Oral medicinal composition for treating breast diseases and preparation method thereof |
| CN104173463A (en) * | 2013-05-23 | 2014-12-03 | 任相生 | Externally applied traditional Chinese medicine for treating lymph node and thyroid |
| CN104758709A (en) * | 2015-04-28 | 2015-07-08 | 张景悦 | Traditional Chinese medicine ointment for treating breast pain and insomnia for acute mastitis patient with abscess |
| CN104857126A (en) * | 2015-06-04 | 2015-08-26 | 夏征梅 | Traditional Chinese medicine composition for treating mammitis |
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