CN1824111A - Cold dissipating network vessel quickening medicinal preparation and its new preparation method - Google Patents
Cold dissipating network vessel quickening medicinal preparation and its new preparation method Download PDFInfo
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- CN1824111A CN1824111A CNA200510134406XA CN200510134406A CN1824111A CN 1824111 A CN1824111 A CN 1824111A CN A200510134406X A CNA200510134406X A CN A200510134406XA CN 200510134406 A CN200510134406 A CN 200510134406A CN 1824111 A CN1824111 A CN 1824111A
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Abstract
A composite Chinese medicine in the form of dripping pill and soft capsule for treating pain of shoulder and back, numbness of limbs and lumbocrural pain, and its preparing process are disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, the particularly a kind of shoulder and back ache that wind-cold damp pathogen causes, numb hand and foot, lumbago and skelalgia, the prescription and preparation technology thereof of row step difficulty etc. of being used for.
Background technology:
The shoulder and back ache that wind-cold damp pathogen causes, numb hand and foot, lumbago and skelalgia, row step difficulty etc. are clinically to see that symptom, the traditional Chinese medical science often take wind-evil dispelling and cold-evil expelling more, the means of relaxing muscles and tendons and activating QI and blood in the collateral are treated it, and evident in efficacy.The cold dissipating network vessel quickening medicinal ball is that it represents medicine.But in the practice, because this medicine is medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, its pill that makes can be used for curing mainly the shoulder and back ache that wind-cold damp pathogen causes, numb hand and foot, lumbago and skelalgia, row step difficulty etc.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
60～300 parts of 80～400 parts of Pheretimas of 100～500 parts of Eupolyphaga Seu Steleophagas of Zaocys
100～500 parts of 60～300 portions of Herba Schizonepetae of 80～400 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
80～400 parts of 40～200 parts of Radix Clematidis of 40～200 parts of Radix Aconiti Kusnezoffii Preparatas of Radix Aconiti Preparata
60～300 parts of 80～400 parts of Ramulus Cinnamomi of 100～500 portions of Rhizoma Cyperis of Radix Saposhnikoviae (vinegar system)
Preferably:
150 parts of 200 parts of Pheretimas of 250 parts of Eupolyphaga Seu Steleophagas of Zaocys
250 parts of 150 portions of Herba Schizonepetae of 200 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
200 parts of 100 parts of Radix Clematidis of 100 parts of Radix Aconiti Kusnezoffii Preparatas of Radix Aconiti Preparata
150 parts of 200 parts of Ramulus Cinnamomi of 250 portions of Rhizoma Cyperis of Radix Saposhnikoviae (vinegar system)
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, syrup, unguentum, medicated wine, tincture.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) gets Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Cyperi four Chinese medicine material, adopt supercritical extraction (or steam distillation): the medical material of pulverizing is dropped in the supercritical extraction reactor, as extracting pressure 10～40Pa, 50～65 ℃ of extraction temperature, resolution temperature I50～65 ℃, resolution temperature II25～35 ℃, extraction time 3.0～5.0h, extract; β-CDBao He, optimised process is: water oil is 1: 6～15 with β-CD ratio, ultrasonic 30～70min gets clathrate;
(2) get Zaocys, Eupolyphaga Seu Steleophaga, Pheretima, Radix Angelicae Pubescentis four Chinese medicine material, stir with 5～15 times of amount 50～95% ethanol and soak 1.5～72h, extract 2～6 times, filter, filtrate decompression concentrates promptly;
(3) get the residue medical material, decoct with water 2～4 times, each 0.5～2.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 5～15 times of amount 60～95% ethanol, left standstill 6～48h, filtered, and the filtrate blood pressure lowering concentrates, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting the Radix Angelicae Pubescentis medical material beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to the influence of rat Ovum Gallus domesticus album foot swelling
Get 40 of healthy male white rats, be divided into 4 groups at random.Dosage and grouping see Table 1, before the experiment Ovum Gallus domesticus album 0.1ml injected to cause under the right back sufficient plantar aponeurosis of rat scorchingly not to compare to cause the scorching left back sufficient sole of the foot, with the difference of both sufficient sole of the foot girths as the swelling level index.Cause the scorching sufficient sole of the foot and be coated with medicine with prescribed dose.The results are shown in Table 1.As shown in Table 1, each extractum group and Anisodus carniolicoides C.Y.Wu et C.Chen are being coated with back 1 hour, and detumescence degree and matched group are relatively learned by statistics and handled difference not remarkable (P＞0.05).Behind the coating 1.5,2.0,2.5,3.0 hours, each extractum group caused the detumescence gradually of scorching foot, detumescence degree and matched group comparing difference highly significant (P＜0.01).
Table 1 pair Ovum Gallus domesticus album cause rat paw edema influence (x ± s, n=10)
| Group | Dosage (g/ only) | Cause scorching back different time (hour) foot swelling degree (mm) | ||||
| 1.0 | 1.5 | 2.0 | 2.5 | 3.0 | ||
| Matched group Anisodus carniolicoides C.Y.Wu et C.Chen technology is 2. extractum group of extractum group technology 1. | - 0.01 0.03 0.05 | 9.9±1.72 8.8±0.63 8.5±2.12 8.7±1.58 | 11.0±0.67 8.6±0.70 ** 8.8±1.39 ** 8.9±2.12 ** | 10.8±1.32 8.7±0.95 ** 8.2±1.03 ** 8.7±1.90 ** | 9.2±0.92 8.9±1.20 7.7±2.11 8.6±1.57 | 5.8±1.48 4.9±1.10 5.3±1.64 5.6±1.55 |
Compare with the blank group
*P＜0.05,
*P＜0.01 (down together)
2, to the influence of rat formaldehyde foot swelling
Get 40 of healthy male white rats, be divided into 4 groups at random, grouping and dosage see Table 2, will cause inflammation under the right back sufficient plantar aponeurosis of 2% formaldehyde 0.1ml injection rat before the experiment.Not causing scorching left side foot in contrast, with the difference of both sufficient sole of the foot girths as the swelling level index.Cause the scorching sufficient sole of the foot and be coated with, measured 1 time in 8,16,24,48,72 hours respectively at causing scorching back with medicine.1 medicine of repaste after every survey 1 time is coated with 5 times altogether, the results are shown in Table 2.
The influence of table 2 pair rat formaldehyde foot swelling (x ± s, n=10)
| Group | Dosage (g/ only) | Cause scorching back different time (hour) foot swelling degree (mm) | ||||
| 8 | 16 | 24 | 48 | 72 | ||
| Matched group Anisodus carniolicoides C.Y.Wu et C.Chen technology is 2. extractum group of extractum group technology 1. | - 0.01 0.03 0.05 | 9.4±1.53 8.9±1.70 8.5±1.91 8.7±1.82 | 1.07±1.23 9.1±2.23 ** 8.8±2.06 * 9.0±2.42 | 11.9±1.89 9.8±1.22 ** 9.3±1.87 ** 9.6±1.93 * | 11.6±1.40 9.3±1.81 9.0±1.94 ** 9.1±2.10 ** | 11.4±1.92 9.1±1.57 8.9±1.63 ** 9.0±1.94 ** |
As shown in Table 2, technology 1. extractum just had the effect of obvious suppression rat foot swelling in 16 hours, and the effect that rat causes scorching foot swelling that suppresses was all arranged after 24 hours, difference highly significant or significantly (P＜0.01 or P＜0.05).
3, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are the shoulder and back aches that a kind of good treatment wind-cold damp pathogen causes, numb hand and foot, lumbago and skelalgia, the medicine of row step difficulty etc., and change preparation technology, can obviously strengthen its wind-evil dispelling and cold-evil expelling, clinical efficacies such as relaxing muscles and tendons and activating QI and blood in the collateral, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Zaocys 100g Eupolyphaga Seu Steleophaga 80g Pheretima 60g
Radix Angelicae Pubescentis 80g Rhizoma Et Radix Notopterygii 60g Herba Schizonepetae 100g
Radix Aconiti Preparata 40g Radix Aconiti Kusnezoffii Preparata 40g Radix Clematidis 80g
Radix Saposhnikoviae 100g Rhizoma Cyperi (vinegar system) 80g Ramulus Cinnamomi 60g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) gets Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Cyperi four Chinese medicine material, adopt supercritical extraction (or steam distillation): the medical material of pulverizing is dropped in the supercritical extraction reactor, as extracting pressure 30Pa, 60 ℃ of extraction temperature, 60 ℃ of resolution temperature I, 30 ℃ of resolution temperature II, extraction time 4.0h gets extract; β-CDBao He, optimised process is: water oil is 1: 10 with β-CD ratio, ultrasonic 40min gets clathrate;
(2) get Zaocys, Eupolyphaga Seu Steleophaga, Pheretima, Radix Angelicae Pubescentis four Chinese medicine material, stir with 10 times of amount 85% ethanol and soak 24h, extract 4 times, filter, filtrate decompression concentrates promptly;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 10 times of amount 95% ethanol, left standstill 12h, filtered, and the filtrate blood pressure lowering concentrates, and is standby;
(4) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Zaocys 150g Eupolyphaga Seu Steleophaga 120g Pheretima 90g
Radix Angelicae Pubescentis 120g Rhizoma Et Radix Notopterygii 90g Herba Schizonepetae 150g
Radix Aconiti Preparata 60g Radix Aconiti Kusnezoffii Preparata 60g Radix Clematidis 120g
Radix Saposhnikoviae 150g Rhizoma Cyperi (vinegar system) 120g Ramulus Cinnamomi 90g
PEG400 160g
Make 1000
Preparation method:
(1) gets Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Cyperi four Chinese medicine material, adopt supercritical extraction (or steam distillation): the medical material of pulverizing is dropped in the supercritical extraction reactor, as extracting pressure 30Pa, 60 ℃ of extraction temperature, 60 ℃ of resolution temperature I, 30 ℃ of resolution temperature II, extraction time 4.0h gets extract; β-CDBao He, optimised process is: water oil is 1: 10 with β-CD ratio, ultrasonic 40min gets clathrate;
(2) get Zaocys, Eupolyphaga Seu Steleophaga, Pheretima, Radix Angelicae Pubescentis four Chinese medicine material, stir with 10 times of amount 85% ethanol and soak 24h, extract 4 times, filter, filtrate decompression concentrates promptly;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 10 times of amount 95% ethanol, left standstill 12h, filtered, and the filtrate blood pressure lowering concentrates, and is standby;
(4) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Zaocys 500g Eupolyphaga Seu Steleophaga 400g Pheretima 300g
Radix Angelicae Pubescentis 400g Rhizoma Et Radix Notopterygii 300g Herba Schizonepetae 500g
Radix Aconiti Preparata 200g Radix Aconiti Kusnezoffii Preparata 200g Radix Clematidis 400g
Radix Saposhnikoviae 500g Rhizoma Cyperi (vinegar system) 400g Ramulus Cinnamomi 300g
Make 1000g
Preparation method:
(1) getting the Radix Angelicae Pubescentis medical material beats powder and is used as medicine;
(2) get Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Cyperi four Chinese medicine material, adopt supercritical extraction (or steam distillation): the medical material of pulverizing is dropped in the supercritical extraction reactor, as extracting pressure 30Pa, 60 ℃ of extraction temperature, 60 ℃ of resolution temperature I, 30 ℃ of resolution temperature II, extraction time 4.0h gets extract; β-CDBao He, optimised process is: water oil is 1: 10 with β-CD ratio, ultrasonic 40min gets clathrate;
(3) get Zaocys, Eupolyphaga Seu Steleophaga, Pheretima three flavor medical materials, stir with 10 times of amount 85% ethanol and soak 24h, extract 4 times, filter, filtrate decompression concentrates promptly;
(4) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 10 times of amount 95% ethanol, left standstill 12h, filtered, and the filtrate blood pressure lowering concentrates, and is standby;
(5) above active component is merged, add aspartame 5.0g, dextrin 150.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Zaocys 142.5g Eupolyphaga Seu Steleophaga 114g Pheretima 85.5g
Radix Angelicae Pubescentis 114g Rhizoma Et Radix Notopterygii 85.5g Herba Schizonepetae 142.5g
Radix Aconiti Preparata 57g Radix Aconiti Kusnezoffii Preparata 57g Radix Clematidis 114g
Radix Saposhnikoviae 142.5g Rhizoma Cyperi (vinegar system) 114g Ramulus Cinnamomi 85.5g
Make 1000
Preparation method:
(1) getting the Radix Angelicae Pubescentis medical material beats powder and is used as medicine;
(2) get Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Cyperi four Chinese medicine material, adopt supercritical extraction (or steam distillation): the medical material of pulverizing is dropped in the supercritical extraction reactor, as extracting pressure 30Pa, 60 ℃ of extraction temperature, 60 ℃ of resolution temperature I, 30 ℃ of resolution temperature II, extraction time 4.0h gets extract; β-CDBao He, optimised process is: water oil is 1: 10 with β-CD ratio, ultrasonic 40min gets clathrate;
(3) get Zaocys, Eupolyphaga Seu Steleophaga, Pheretima three flavor medical materials, stir with 10 times of amount 85% ethanol and soak 24h, extract 4 times, filter, filtrate decompression concentrates promptly;
(4) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 10 times of amount 95% ethanol, left standstill 12h, filtered, and the filtrate blood pressure lowering concentrates, and is standby;
(5) above active component is merged, add aspartame 3.0g, mannitol 260.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
60～300 parts of 80～400 parts of Pheretimas of 100～500 parts of Eupolyphaga Seu Steleophagas of Zaocys
100～500 parts of 60～300 portions of Herba Schizonepetae of 80～400 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
80～400 parts of 40～200 parts of Radix Clematidis of 40～200 parts of Radix Aconiti Kusnezoffii Preparatas of Radix Aconiti Preparata
60～300 parts of 80～400 parts of Ramulus Cinnamomi of 100～500 portions of Rhizoma Cyperis of Radix Saposhnikoviae (vinegar system).
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
150 parts of 200 parts of Pheretimas of 250 parts of Eupolyphaga Seu Steleophagas of Zaocys
250 parts of 150 portions of Herba Schizonepetae of 200 portions of Rhizoma Et Radix Notopterygiis of Radix Angelicae Pubescentis
200 parts of 100 parts of Radix Clematidis of 100 parts of Radix Aconiti Kusnezoffii Preparatas of Radix Aconiti Preparata
150 parts of 200 parts of Ramulus Cinnamomi of 250 portions of Rhizoma Cyperis of Radix Saposhnikoviae (vinegar system).
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, tablet, mixture, syrup, unguentum, medicated wine, tincture.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) get Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Cyperi four Chinese medicine material, adopt supercritical extraction (or steam distillation):
The medical material of pulverizing is dropped in the supercritical extraction reactor, as extracting pressure 10～40Pa, 50～65 ℃ of extraction temperature, resolution temperature I50～65 ℃, resolution temperature II25～35 ℃, extraction time 3.0～5.0h, extract; β-CDBao He, optimised process is: water oil is 1: 6～15 with β-CD ratio, ultrasonic 30～70min gets clathrate;
(2) get Zaocys, Eupolyphaga Seu Steleophaga, Pheretima, Radix Angelicae Pubescentis four Chinese medicine material, stir with 5～15 times of amount 50～95% ethanol and soak 1.5～72h, extract 2～6 times, filter, filtrate decompression concentrates promptly;
(3) get the residue medical material, decoct with water 2～4 times, each 0.5～2.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 5～15 times of amount 60～95% ethanol, left standstill 6～48h, filtered, and the filtrate blood pressure lowering concentrates, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting the Radix Angelicae Pubescentis medical material beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) get Rhizoma Et Radix Notopterygii, Herba Schizonepetae, Radix Saposhnikoviae, Rhizoma Cyperi four Chinese medicine material, adopt supercritical extraction (or steam distillation):
The medical material of pulverizing is dropped in the supercritical extraction reactor, as extracting pressure 10～40Pa, 50～65 ℃ of extraction temperature, resolution temperature I50～65 ℃, resolution temperature II25～35 ℃, extraction time 3.0～5.0h, extract; β-CDBao He, optimised process is: water oil is 1: 6～15 with β-CD ratio, ultrasonic 30～70min gets clathrate;
(2) get Zaocys, Eupolyphaga Seu Steleophaga, Pheretima, Radix Angelicae Pubescentis four Chinese medicine material, stir with 5～15 times of amount 50～95% ethanol and soak 1.5～72h, extract 2～6 times, filter, filtrate decompression concentrates promptly;
(3) get the residue medical material, decoct with water 2～4 times, each 0.5～2.5 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 5～15 times of amount 60～95% ethanol, left standstill 6～48h, filtered, and the filtrate blood pressure lowering concentrates, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) getting the Radix Angelicae Pubescentis medical material beats powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200510134406XA CN1824111A (en) | 2005-12-15 | 2005-12-15 | Cold dissipating network vessel quickening medicinal preparation and its new preparation method |
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| CNA200510134406XA CN1824111A (en) | 2005-12-15 | 2005-12-15 | Cold dissipating network vessel quickening medicinal preparation and its new preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988563A (en) * | 2012-08-13 | 2013-03-27 | 李承平 | Fumigation medicaments for stimulating circulation of blood and causing muscles and joints to relax |
| CN104042824A (en) * | 2014-06-26 | 2014-09-17 | 长春人民药业集团有限公司 | Preparation and detecting methods of traditional Chinese medicine composition for treating wind-cold-wetness evil |
-
2005
- 2005-12-15 CN CNA200510134406XA patent/CN1824111A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988563A (en) * | 2012-08-13 | 2013-03-27 | 李承平 | Fumigation medicaments for stimulating circulation of blood and causing muscles and joints to relax |
| CN104042824A (en) * | 2014-06-26 | 2014-09-17 | 长春人民药业集团有限公司 | Preparation and detecting methods of traditional Chinese medicine composition for treating wind-cold-wetness evil |
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