CN1823910A - Joint pain preparation and its new preparation method - Google Patents
Joint pain preparation and its new preparation method Download PDFInfo
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Abstract
A Chinese medicine in the form of dripping pill or soft capsule for treating rheumatic tendon-bone pain, rheumatic arthrodynia, and numbness of extremities is disclosed. Its preparing process is also disclosed.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind ofly be used for rheumatic muscles and bones and ache arthralgia, the prescription of numb limbs and tense tendons and preparation technology thereof.
Background technology:
Rheumatic muscles and bones is ached, arthralgia, and numb limbs and tense tendons is clinically to see that symptom, the traditional Chinese medical science often take to dispel the wind more, dehumidifying, the analgesic means are treated it, and evident in efficacy.The joint pain ball is that it represents medicine.But in the practice, because this medicine is the part medical material to be beaten powder be used as medicine in preparation, cause impurity many, shortcoming such as dosage is big has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, its pill that makes can be used for curing mainly rheumatic muscles and bones and aches, arthralgia, numb limbs and tense tendons.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
52～416 parts of 52～416 parts of Herba Lycopodiis of 69～552 parts of Rhizoma Cibotii of Herba Siegesbeckiae
52～416 parts of 35～280 parts of Radixs Stephaniae Tetrandrae of 52～416 portions of Caulis Spatholobis of Radix Gentianae Macrophyllae
26～208 parts of 52～416 parts of Cortex Acanthopanciss of 35～280 parts of Ramulus Moris of Herba Erodii
26～208 parts of Radix Angelicae Pubescentiss
Preferably:
104 parts of 104 parts of Herba Lycopodiis of 138 parts of Rhizoma Cibotii of Herba Siegesbeckiae
104 parts of 70 parts of Radixs Stephaniae Tetrandrae of 104 portions of Caulis Spatholobis of Radix Gentianae Macrophyllae
52 parts of 104 parts of Cortex Acanthopanciss of 70 parts of Ramulus Moris of Herba Erodii
52 parts of Radix Angelicae Pubescentiss
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, capsule, granule, tablet, mixture, emplastrum, medicated wine, fluid extract and extractum, soft extract.
The above new technology of the present invention may further comprise the steps:
Method a:(technology 1.)
(1) Qu Herba Siegesbeckiae, Radix Gentianae Macrophyllae, Radix Angelicae Pubescentis three flavor medical materials are ground into coarse powder, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with the ethanol of 5～40 times of amounts 50～95%, and slowly percolation is collected percolate, reclaims ethanol, is condensed into thick extractum;
(2) get Radix Stephaniae Tetrandrae, Cortex Acanthopancis medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～5 times, each 0.5～3.0 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 6～15 times of amount 60～95% ethanol, left standstill, and filtered, and filtrate decompression is condensed into thick extractum, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Radix Stephaniae Tetrandrae, the Cortex Acanthopancis medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out tool main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, pharmacological research
1.1 influence to the mice capillary permeability
Get 40 of body weight 18～22g healthy mices, male and female half and half are divided into 4 groups at random, and grouping sees Table 1 with dosage.Irritate stomach every day once, one week of successive administration is behind last administration 30min, tail vein injection Yi Wensilan 0.1ml/, simultaneously, lumbar injection 0.6% acetic acid 0.2ml/ only, behind the 20min, sacrificed by decapitation is cut off abdominal cavity 5ml distilled water flushing abdominal cavity 3 times, draws the about 4ml of abdominal cavity eluate with suction pipe, centrifugal 5min (1000 rev/mins), get supernatant 3ml, measure trap (OD value) at 751 spectrophotometer 590nm places, the results are shown in Table 1.
The influence of table 1 pair mice capillary permeability (n=10, x ± SD)
| Group | Dosage (g/kg) | Trap (OD value) |
| Technology is 2. extractum group positive drug group ordinary water group of extractum group technology 1. | 0.5 1.2 0.225 equal-volume water | 0.131±0.018 ** 0.156.±0.029 * 0.157±0.052 0.189±0.037 |
Annotate: compare with the ordinary water group
*P＜0.05,
*P＜0.01
As seen, compare with the ordinary water group, technology 1., 2. the extractum group all can significantly suppress the mice capillary permeability.
1.2 to the granulomatous influence of rat Oleum Tiglii air bag
Get 32 of the male rats of 160 ± 20g, under the ether light anaesthesia, after the local skin sterilization of back, in the interscapular region, subcutaneous injection 20ml air, form air bag, in air bag, inject disinfectant 1% Oleum Tiglii 1ml immediately, with the Mus back of the body down, rotate slowly immediately, Oleum Tiglii is fully contacted with capsule inner tissue, take out gas in the body behind the 24h.Cause inflammation and the same day rat is divided into four groups of gastric infusions at random, grouping sees Table 2 with dosage.Be administered once every day, continuous irrigation stomach 7 days.Behind last administration 24h, to weigh, etherization is put to death, and peels off the cyst wall granuloma, and it is clean to put in the normal saline rinsing, dries in 60 ℃ of baking boxs, weighs, and the results are shown in Table 2.
The table 2 pair granulomatous influence of rat Oleum Tiglii air bag (n=8, x ± SD)
| Group | Dosage (g/kg) | Granuloma heavy (mg/100g) |
| Technology is 2. extractum group positive drug group ordinary water group of extractum group technology 1. | 0.25 0.6 0.1125 equal-volume water | 253.7±63.2 ** 290.8±49.7 ** 423.4±18.6 580.3±78.1 |
Annotate: compare with the ordinary water group
*P＜0.01
The result shows, compares with the ordinary water group, and the large and small dosage group of medicine has extremely significantly inhibitory action to rat Oleum Tiglii air bag granuloma, illustrates that this extractum group has antiinflammatory action preferably.
1.3 therapeutical effect to rat assist agent arthritis
Get 32 of the healthy male rats of body weight 140～190g, measure the left and right metapedes sole of the foot of every Mus girth with tape, injection Freund ' s Freund's complete adjuvant 0.05ml causes inflammation in the right back sufficient sole of the foot of every then Mus.After causing scorching 19 days, rat is divided into four groups at random by the swollen degree of foot, the beginning gastric infusion.Grouping and filling stomach dosage are with 1.2.Be administered once every day, two weeks of continuous irrigation stomach.In the forward and backward left and right hind foot swelling of the rat degree of measuring every a day of administration, the results are shown in Table 3, table 4.The scorching front foot sole of the foot girth of the scorching metapedes sole of the foot girth of swelling degree=cause-cause.
The therapeutical effect of table 3 pair rat assist agent arthritis constitutional swelling (right foot) (n=8, x ± SD)
| Group | Dosage (g/kg) | Paw swelling (mm) before the medication | Different time after the medication (my god) paw swelling (mm) | |||
| The 7th day | The 9th day | The 11st day | The 13rd day | |||
| Technology is 2. extractum group positive drug group ordinary water group of extractum group technology 1. | 0.25 0.6 0.1125 equal-volume water | 1.21±0.33 1.28±0.23 1.29±0.18 1.28±0.23 | 0.65±0.27 * 0.76±0.13 0.97±0.35 1.21±0.27 | 0.55±0.2 ** 0.62±0.15 ** 0.91±0.28 1.16±0.12 | 0.50±0.24 ** 0.52±0.28 ** 0.84±0.31 1.13±0.43 | 0.48±0.11 ** 0.50±0.13 ** 0.72±0.37 0.99±0.21 |
Annotate: compare with the ordinary water group
*P＜0.05,
*P＜0.01
The result shows, with the ordinary water group relatively, administration the 7th day its foot swelling is promptly begun to occur remarkable inhibitory action (P＜0.05); Technology 2. extractum group began to occur remarkable inhibitory action on the 9th day in administration.Illustrate that swelling has therapeutical effect preferably to medicine to the adjuvant arthritis constitutional.
The therapeutical effect of table 4 pair rat assist agent arthritis Secondary cases swelling (left side foot) (n=8, x ± SD)
| Group | Dosage (g/kg) | Paw swelling (mm) before the medication | Different time after the medication (my god) paw swelling (mm) | |||
| The 7th day | The 9th day | The 11st day | The 13rd day | |||
| Technology is 2. extractum group positive drug group ordinary water group of extractum group technology 1. | 0.25 0.6 0.1125 equal-volume water | 0.38±0.17 0.36±0.11 0.35±0.15 0.37±0.10 | 0.15±0.07 * 0.17±0.03 * 0.23±0.15 0.32±0.11 | 0.12±0.04 * 0.13±0.11 * 0.16±0.12 * 0.28±0.09 | 0.09±0.03 * 0.11±0.10 0.17±0.13 0.25±0.15 | 0.03±0.02 * 0.09±0.07 0.16±0.10 0.21±0.07 |
Annotate: compare with the ordinary water group
*P＜0.05
The result shows, with the ordinary water group relatively, technology 1. extractum group, technology 2. the extractum group administration the 7th day its foot swelling is promptly begun to occur remarkable inhibitory action (P＜0.05).Illustrate that swelling also has therapeutical effect preferably to medicine to the adjuvant arthritis Secondary cases.
2, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are that a kind of good treatment rheumatic muscles and bones is ached, arthralgia, the medicine of numb limbs and tense tendons, and change preparation technology, can obviously strengthen it and dispel the wind, dehumidifying, clinical efficacies such as pain relieving, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Herba Siegesbeckiae 138g Rhizoma Cibotii 104g Herba Lycopodii 104g
Radix Gentianae Macrophyllae 104g Caulis Spatholobi 70g Radix Stephaniae Tetrandrae 104g
Herba Erodii 70g Ramulus Mori 104g Cortex Acanthopancis 52g
Radix Angelicae Pubescentis 52g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) Qu Herba Siegesbeckiae, Radix Gentianae Macrophyllae, Radix Angelicae Pubescentis three flavor medical materials are ground into coarse powder, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with the ethanol of 20 times of amounts 70%, and slowly percolation is collected percolate, reclaims ethanol, is condensed into thick extractum;
(2) get Radix Stephaniae Tetrandrae, Cortex Acanthopancis medical material, soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 10 times of amount 95% ethanol, left standstill, and filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(4) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Herba Siegesbeckiae 552g Rhizoma Cibotii 416g Herba Lycopodii 416g
Radix Gentianae Macrophyllae 416g Caulis Spatholobi 280g Radix Stephaniae Tetrandrae 416g
Herba Erodii 280g Ramulus Mori 416g Cortex Acanthopancis 208g
Radix Angelicae Pubescentis 208g
PEG400 490g
Make 1000
Preparation method:
(1) Qu Herba Siegesbeckiae, Radix Gentianae Macrophyllae, Radix Angelicae Pubescentis three flavor medical materials are ground into coarse powder, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with the ethanol of 20 times of amounts 70%, and slowly percolation is collected percolate, reclaims ethanol, is condensed into thick extractum;
(2) get Radix Stephaniae Tetrandrae, Cortex Acanthopancis medical material, soaked 30 minutes earlier with 75% ethanol, reheat reflux, extract, 3 times, each 1 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 10 times of amount 95% ethanol, left standstill, and filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(4) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Herba Siegesbeckiae 414g Rhizoma Cibotii 312g Herba Lycopodii 312g
Radix Gentianae Macrophyllae 312g Caulis Spatholobi 210g Radix Stephaniae Tetrandrae 312g
Herba Erodii 210g Ramulus Mori 312g Cortex Acanthopancis 156g
Radix Angelicae Pubescentis 156g
Make 1000g
Preparation method:
(1) Qu Herba Siegesbeckiae, Radix Gentianae Macrophyllae, Radix Angelicae Pubescentis three flavor medical materials are ground into coarse powder, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with the ethanol of 20 times of amounts 70%, and slowly percolation is collected percolate, reclaims ethanol, is condensed into thick extractum;
(2) get Radix Stephaniae Tetrandrae, the Cortex Acanthopancis medical material is beaten powder and is used as medicine;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 10 times of amount 95% ethanol, left standstill, and filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(4) above active component is merged, add aspartame 5.0g, dextrin 290.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Herba Siegesbeckiae 290g Rhizoma Cibotii 218g Herba Lycopodii 218g
Radix Gentianae Macrophyllae 218g Caulis Spatholobi 147g Radix Stephaniae Tetrandrae 218g
Herba Erodii 147g Ramulus Mori 218g Cortex Acanthopancis 109g
Radix Angelicae Pubescentis 109g
Make 1000
Preparation method:
(1) Qu Herba Siegesbeckiae, Radix Gentianae Macrophyllae, Radix Angelicae Pubescentis three flavor medical materials are ground into coarse powder, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with the ethanol of 20 times of amounts 70%, and slowly percolation is collected percolate, reclaims ethanol, is condensed into thick extractum;
(2) get Radix Stephaniae Tetrandrae, the Cortex Acanthopancis medical material is beaten powder and is used as medicine;
(3) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 10 times of amount 95% ethanol, left standstill, and filtered, and filtrate decompression is condensed into thick extractum, and is standby;
(4) above active component is merged, add aspartame 3.0g, mannitol 200.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
52～416 parts of 52～416 parts of Herba Lycopodiis of 69～552 parts of Rhizoma Cibotii of Herba Siegesbeckiae
52～416 parts of 35～280 parts of Radixs Stephaniae Tetrandrae of 52～416 portions of Caulis Spatholobis of Radix Gentianae Macrophyllae
26～208 parts of 52～416 parts of Cortex Acanthopanciss of 35～280 parts of Ramulus Moris of Herba Erodii
26～208 parts of Radix Angelicae Pubescentiss.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
104 parts of 104 parts of Herba Lycopodiis of 138 parts of Rhizoma Cibotii of Herba Siegesbeckiae
70 parts anti-104 parts of 104 portions of Caulis Spatholobis of Radix Gentianae Macrophyllae
52 parts of 104 parts of Cortex Acanthopanciss of 70 parts of Ramulus Moris of Herba Erodii
52 parts of Radix Angelicae Pubescentiss.
3, claim 1 or any one Chinese medicine preparation of 2 are drop pill, capsule, granule, tablet, mixture, emplastrum, medicated wine, fluid extract and extractum, soft extract.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
Method a:(technology 1.)
(1) Qu Herba Siegesbeckiae, Radix Gentianae Macrophyllae, Radix Angelicae Pubescentis three flavor medical materials are ground into coarse powder, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with the ethanol of 5～40 times of amounts 50～95%, and slowly percolation is collected percolate, reclaims ethanol, is condensed into thick extractum;
(2) get Radix Stephaniae Tetrandrae, Cortex Acanthopancis medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～5 times, each 0.5～3.0 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 6～15 times of amount 60～95% ethanol, left standstill, and filtered, and filtrate decompression is condensed into thick extractum, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Radix Stephaniae Tetrandrae, the Cortex Acanthopancis medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, interior glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
Method a:(technology 1.)
(1) Qu Herba Siegesbeckiae, Radix Gentianae Macrophyllae, Radix Angelicae Pubescentis three flavor medical materials are ground into coarse powder, according to the percolation (appendix IO) under fluid extract and the extractum item, make solvent with the ethanol of 5～40 times of amounts 50～95%, and slowly percolation is collected percolate, reclaims ethanol, is condensed into thick extractum;
(2) get Radix Stephaniae Tetrandrae, Cortex Acanthopancis medical material, soaked 30～60 minutes earlier with 50～95% ethanol, reheat reflux, extract, 2～5 times, each 0.5～3 hour, merge extractive liquid,, concentrating under reduced pressure becomes thick paste, and is standby;
(3) get the residue medical material, decoct with water 2～5 times, each 0.5～3.0 hour, collecting decoction filtered, and filtrate is condensed into certain volume, stirred evenly with 6～15 times of amount 60～95% ethanol, left standstill, and filtered, and filtrate decompression is condensed into thick extractum, and is standby.
Above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Method b:(technology 2.)
(1) get Radix Stephaniae Tetrandrae, the Cortex Acanthopancis medical material is beaten powder and is used as medicine;
(2) prescription residue medical material is handled the same;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing the various preparations except that drop pill and soft capsule of the present invention.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510134429 CN1823910A (en) | 2005-12-15 | 2005-12-15 | Joint pain preparation and its new preparation method |
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| CN 200510134429 CN1823910A (en) | 2005-12-15 | 2005-12-15 | Joint pain preparation and its new preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102755387A (en) * | 2012-06-13 | 2012-10-31 | 王晓兵 | Traditional Chinese medicinal plaster for treating rheumatalgia caused by hepatorenal deficiency |
| CN103301249A (en) * | 2012-03-15 | 2013-09-18 | 涂子雄 | Arthritis externally-applied Chinese herbal medicine |
| CN105878656A (en) * | 2014-10-10 | 2016-08-24 | 王强 | Ancestral method for producing plasters for treating rheumatic bone diseases |
| CN110755479A (en) * | 2019-11-20 | 2020-02-07 | 健民药业集团股份有限公司 | External gel patch for treating arthritis |
| CN112972557A (en) * | 2021-04-21 | 2021-06-18 | 周贤升 | Medicinal liquor for treating arthralgia and myalgia and preparation method thereof |
-
2005
- 2005-12-15 CN CN 200510134429 patent/CN1823910A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301249A (en) * | 2012-03-15 | 2013-09-18 | 涂子雄 | Arthritis externally-applied Chinese herbal medicine |
| CN102755387A (en) * | 2012-06-13 | 2012-10-31 | 王晓兵 | Traditional Chinese medicinal plaster for treating rheumatalgia caused by hepatorenal deficiency |
| CN102755387B (en) * | 2012-06-13 | 2015-04-22 | 王晓兵 | Traditional Chinese medicinal plaster for treating rheumatalgia caused by hepatorenal deficiency |
| CN105878656A (en) * | 2014-10-10 | 2016-08-24 | 王强 | Ancestral method for producing plasters for treating rheumatic bone diseases |
| CN110755479A (en) * | 2019-11-20 | 2020-02-07 | 健民药业集团股份有限公司 | External gel patch for treating arthritis |
| CN110755479B (en) * | 2019-11-20 | 2021-08-03 | 健民药业集团股份有限公司 | External gel patch for treating arthritis |
| CN112972557A (en) * | 2021-04-21 | 2021-06-18 | 周贤升 | Medicinal liquor for treating arthralgia and myalgia and preparation method thereof |
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